L-Tryptophan (BioDeep_00000000127)

 

Secondary id: BioDeep_00000014646, BioDeep_00000014689, BioDeep_00000229600, BioDeep_00000398011, BioDeep_00000398601, BioDeep_00000409081, BioDeep_00001868002, BioDeep_00001891645

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


L-Tryptophan, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0\\%

化学式: C11H12N2O2 (204.0898732)
中文名称: DL-色氨酸, L-色氨酸, 色氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.01%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

L-Tryptophan. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/l-tryptophan (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000000127). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)N
InChI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)

描述信息

Tryptophan (Trp) or L-tryptophan is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-tryptophan is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Tryptophan is found in all organisms ranging from bacteria to plants to animals. It is classified as a non-polar, uncharged (at physiological pH) aromatic amino acid. Tryptophan is an essential amino acid, meaning the body cannot synthesize it, and it must be obtained from the diet. The requirement for tryptophan and protein decreases with age. The minimum daily requirement for adults is 3 mg/kg/day or about 200 mg a day. There is 400 mg of tryptophan in a cup of wheat germ. A cup of low-fat cottage cheese contains 300 mg of tryptophan and chicken and turkey contain up to 600 mg of tryptophan per pound (http://www.dcnutrition.com). Tryptophan is particularly plentiful in chocolate, oats, dried dates, milk, yogurt, cottage cheese, red meat, eggs, fish, poultry, sesame, chickpeas, almonds, sunflower seeds, pumpkin seeds, buckwheat, spirulina, and peanuts. Tryptophan is the precursor of both serotonin and melatonin. Melatonin is a hormone that is produced by the pineal gland in animals, which regulates sleep and wakefulness. Serotonin is a brain neurotransmitter, platelet clotting factor, and neurohormone found in organs throughout the body. Metabolism of tryptophan into serotonin requires nutrients such as vitamin B6, niacin, and glutathione. Niacin (also known as vitamin B3) is an important metabolite of tryptophan. It is synthesized via kynurenine and quinolinic acids, which are products of tryptophan degradation. There are a number of conditions or diseases that are characterized by tryptophan deficiencies. For instance, fructose malabsorption causes improper absorption of tryptophan in the intestine, which reduces levels of tryptophan in the blood and leads to depression. High corn diets or other tryptophan-deficient diets can cause pellagra, which is a niacin-tryptophan deficiency disease with symptoms of dermatitis, diarrhea, and dementia. Hartnups disease is a disorder in which tryptophan and other amino acids are not absorbed properly. Symptoms of Hartnups disease include skin rashes, difficulty coordinating movements (cerebellar ataxia), and psychiatric symptoms such as depression or psychosis. Tryptophan supplements may be useful for treating Hartnups disease. Assessment of tryptophan deficiency is done through studying excretion of tryptophan metabolites in the urine or blood. Blood may be the most sensitive test because the amino acid tryptophan is transported in a unique way. Increased urination of tryptophan breakdown products (such as kynurenine) correlates with increased tryptophan degradation, which occurs with oral contraception, depression, mental retardation, hypertension, and anxiety states. Tryptophan plays a role in "feast-induced" drowsiness. Ingestion of a meal rich in carbohydrates triggers the release of insulin. Insulin, in turn, stimulates the uptake of large neutral branched-chain amino acids (BCAAs) into muscle, increasing the ratio of tryptophan to BCAA in the bloodstream. The increased tryptophan ratio reduces competition at the large neutral amino acid transporter (which transports both BCAAs and tryptophan), resulting in greater uptake of tryptophan across the blood-brain barrier into the cerebrospinal fluid (CSF). Once in the CSF, tryptophan is converted into serotonin and the resulting serotonin is further metabolized into melatonin by the pineal gland, which promotes sleep. Because tryptophan is converted into 5-hydroxytryptophan (5-HTP) which is then converted into the neurotransmitter serotonin, it has been proposed th...
L-tryptophan is a white powder with a flat taste. An essential amino acid; occurs in isomeric forms. (NTP, 1992)
L-tryptophan is the L-enantiomer of tryptophan. It has a role as an antidepressant, a nutraceutical, a micronutrient, a plant metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is an erythrose 4-phosphate/phosphoenolpyruvate family amino acid, a proteinogenic amino acid, a tryptophan and a L-alpha-amino acid. It is a conjugate base of a L-tryptophanium. It is a conjugate acid of a L-tryptophanate. It is an enantiomer of a D-tryptophan. It is a tautomer of a L-tryptophan zwitterion.
An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals.
L-Tryptophan is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Tryptophan is the least plentiful of all 22 amino acids and an essential amino acid in humans (provided by food), Tryptophan is found in most proteins and a precursor of serotonin. Tryptophan is converted to 5-hydroxy-tryptophan (5-HTP), converted in turn to serotonin, a neurotransmitter essential in regulating appetite, sleep, mood, and pain. Tryptophan is a natural sedative and present in dairy products, meats, brown rice, fish, and soybeans. (NCI04)
Tryptophan is an essential amino acid which is the precursor of serotonin. Serotonin is a brain neurotransmitter, platelet clotting factor and neurohormone found in organs throughout the body. Metabolism of tryptophan to serotonin requires nutrients such as vitamin B6, niacin and glutathione. Niacin is an important metabolite of tryptophan. High corn or other tryptophan-deficient diets can cause pellagra, which is a niacin-tryptophan deficiency disease with symptoms of dermatitis, diarrhea and dementia. Inborn errors of tryptophan metabolism exist where a tumor (carcinoid) makes excess serotonin. Hartnups disease is a disease where tryptophan and other amino acids are not absorbed properly. Tryptophan supplements may be useful in each condition, in carcinoid replacing the over-metabolized nutrient and in Hartnups supplementing a malabsorbed nutrient. Some disorders of excess tryptophan in the blood may contribute to mental retardation. Assessment of tryptophan deficiency is done through studying excretion of tryptophan metabolites in the urine or blood. Blood may be the most sensitive test because the amino acid tryptophan is transported in a unique way. Increased urination of tryptophan fragments correlates with increased tryptophan degradation, which occurs with oral contraception, depression, mental retardation, hypertension and anxiety states. The requirement for tryptophan and protein decreases with age. Adults minimum daily requirement is 3 mg/kg/day or about 200 mg a day. This may be an underestimation, for there are 400 mg of tryptophan in just a cup of wheat germ. A cup of low fat cottage cheese contains 300 mg of tryptophan and chicken and turkey contain up to 600 mg per pound.
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
See also: Serotonin; tryptophan (component of); Chamomile; ginger; melatonin; thiamine; tryptophan (component of) ... View More ...
Constituent of many plants. Enzymatic hydrolysis production of most plant and animal proteins. Dietary supplement, nutrient
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
COVID info from PDB, Protein Data Bank
The L-enantiomer of tryptophan.
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Acquisition and generation of the data is financially supported in part by CREST/JST.
[Raw Data] CBA09_Tryptophan_pos_30eV_1-1_01_662.txt
[Raw Data] CBA09_Tryptophan_pos_20eV_1-1_01_661.txt
[Raw Data] CBA09_Tryptophan_neg_30eV_1-1_01_716.txt
[Raw Data] CBA09_Tryptophan_pos_10eV_1-1_01_660.txt
[Raw Data] CBA09_Tryptophan_neg_10eV_1-1_01_714.txt
[Raw Data] CBA09_Tryptophan_neg_40eV_1-1_01_717.txt
[Raw Data] CBA09_Tryptophan_neg_20eV_1-1_01_715.txt
[Raw Data] CBA09_Tryptophan_pos_50eV_1-1_01_664.txt
[Raw Data] CBA09_Tryptophan_neg_50eV_1-1_01_718.txt
[Raw Data] CBA09_Tryptophan_pos_40eV_1-1_01_663.txt
IPB_RECORD: 253; CONFIDENCE confident structure
KEIO_ID T003
DL-Tryptophan is an endogenous metabolite.
L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

同义名列表

180 个代谢物同义名

L-Tryptophan, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0\\%; L-Tryptophan, United States Pharmacopeia (USP) Reference Standard; Tryptophan, European Pharmacopoeia (EP) Reference Standard; L-Tryptophan, certified reference material, TraceCERT(R); 1H-INDOLE-3-PROPANOIC ACID, .ALPHA.-AMINO-, (S)-; (S)-alpha-amino-beta-(3-indolyl)-propionic acid; L-Tryptophan, Cell Culture Reagent (H-L-Trp-OH); 1H-Indole-3-propanoic acid, alpha-amino-, (S)-; L-Tryptophan, Vetec(TM) reagent grade, >=98\\%; (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid; (S)-2-amino-3-(1H-Indol-3-yl)-propionic acid; N-ACETYLTRYPTOPHAN IMPURITY A (EP IMPURITY); (S)-(-)-2-Amino-3-(3-indolyl)propionic Acid; N-ACETYLTRYPTOPHAN IMPURITY A [EP IMPURITY]; (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid; (S)-alpha-Amino-beta-(3-indolyl)-propionate; (S)-alpha-Amino-1H-indole-3-propanoic acid; L-Tryptophan, reagent grade, >=98\\% (HPLC); S(-)-1-alpha-Aminoindole-3-propionic acid; 4-(3-METHOXYANILINO)-4-OXOBUT-2-ENOICACID; (S)-alpha-Amino-beta-indolepropionic acid; (S)-Tryptophan 1H-Indole-3-alanine, (S)-; (2S)-2-amino-3-(1H-indol-3-yl)propanoate; (S)-Α-amino-β-(3-indolyl)-propionic acid; (S)-a-Amino-b-(3-indolyl)-propionic acid; (S)-2-Amino-3-(3-indolyl)propionic acid; L-.ALPHA.-AMINO-3-INDOLEPROPIONIC ACID; (S)-alpha-Amino-1H-indole-3-propanoate; alpha-Amino-3-indolepropionic acid, L-; (S)-Α-amino-1H-indole-3-propanoic acid; (S)-a-Amino-1H-indole-3-propanoic acid; (S)-alpha-Aminoindole-3-propionic acid; (s)-alpha-amino-beta-indolepropionate; Propionic acid, 2-amino-3-indol-3-yl-; L-Tryptophan, BioUltra, >=99.5\\% (NT); Indole-3-propionic acid, alpha-amino-; (S)-Α-amino-β-(3-indolyl)-propionate; L-alpha-amino-3-indolepropionic acid; (S)-a-Amino-b-(3-indolyl)-propionate; L-alpha-Aminoindole-3-propionic acid; Indoe-3-propionic acid, alpha-amino-; Propionic acid, 2-amino-3-indol-3-yl; (S)-alpha-Aminoindole-3-propionate; alpha-Amino-3-indolepropionic acid; alpha-Aminoindole-3-propionic acid; (S)-a-Aminoindole-3-propionic acid; (S)-a-Amino-b-indolepropionic acid; (S)-a-Amino-1H-indole-3-propanoate; (S)-Α-amino-1H-indole-3-propanoate; Tryptophan Metabolism Alterations; Pharmascience brand OF tryptophan; L-a-Amino-3-indolepropionic acid; Upsher-smith brand OF tryptophan; 2-Amino-3-indolylpropanoic acid; L-Tryptophan, Vetec(TM), 98.5\\%; (S)-a-Aminoindole-3-propionate; Niddapharm brand OF tryptophan; Ardeypharm brand OF tryptophan; Ratiopharm brand OF tryptophan; (s)-a-amino-b-indolepropionate; L-Alanine, 3-(1H-indol-3-yl)-; 2-Amino-3-indolylpropanoate; Esparma brand OF tryptophan; 3-(1H-indol-3-yl)-L-Alanine; QIVBCDIJIAJPQS-VIFPVBQESA-N; TRYPTOPHAN (USP MONOGRAPH); TRYPTOPHAN [USP MONOGRAPH]; IS_TRYPTOPHAN-2,4,5,6,7-D5; Tryptophan (L-Tryptophan); Kalma brand OF tryptophan; 1H-Indole-3-alanine, (S)-; 1H-Indole-3-alanine (VAN); TRYPTOPHAN (EP MONOGRAPH); Merck brand OF tryptophan; TRYPTOPHAN [EP MONOGRAPH]; L-Tryptophan-13C11,15N2; L-Tryptophan-ratiopharm; L Tryptophan ratiopharm; L-beta-3-Indolylalanine; 1-beta-3-Indolylalanine; ICN brand OF tryptophan; (S)-1H-Indole-3-alanine; Alanine, 3-indol-3-yl-; 1beta-3-Indolylalanine; L-TRYPTOPHAN [USP-RS]; Alanine, 3-indol-3-yl; beta-3-indolylalanine; Tryptophan [USAN:INN]; Tryptophan (USP/INN); Tryptophane [French]; Tryptophan, L- (8CI); Tryptophanum [Latin]; Tryptophanum (Latin); Triptofano [Spanish]; L-TRYPTOPHAN [VANDF]; Tryptophan ((-),l,s); l-b-3-Indolylalanine; L-Β-3-indolylalanine; Tryptophan [WHO-DD]; 1H-Indole-3-alanine; 3-Indol-3-ylalanine; L-Tryptophan (JP17); TRYPTOPHAN [MART.]; L-TRYPTOPHAN [FCC]; TRYPTOPHAN (MART.); L-Tryptophan (9CI); TRYPTOPHAN [VANDF]; L-TRYPTOPHAN [JAN]; TRYPTOPHAN [USAN]; TRYPTOPHAN [INCI]; TRYPTOPHAN [HSDB]; Indole-3-alanine; L-(-)-Tryptophan; L-Tryptophan,(S); ratio-Tryptophan; Tryptophan (VAN); Tryptophan (H-3); TRYPTOPHAN [INN]; ratio Tryptophan; L(-)-Tryptophan; TRYPTOPHAN [MI]; UNII-8DUH1N11BX; TRYPTOPHAN [II]; TRYPTOPHAN (II); (-)-Tryptophan; Levotryptophan; PMS-Tryptophan; PMS Tryptophan; (S)-Tryptophan; Tryptophan, L-; (L)-TRYPTOPHAN; Lopac0_001183; DivK1c_000457; L-Tryptophane; DL-Tryptophan; Tox21_501183; Tox21_300359; Tox21_201246; L-Tryptophan; Tryptophanum; L Tryptophan; KBio1_000457; Lopac-T-0254; Tryptophane; L-Tryptofan; IDI1_000457; Ardeytropin; L-Trytophan; CAS-73-22-3; 8DUH1N11BX; Trytophan-; triptofano; Tryptophan; H-L-Trp-OH; Naturruhe; trytophan; Ardeydorm; tryptacin; AI3-18478; Pacitron; h-Trp-oh; Sedanoct; L-Trp-OH; Tryptan; Optimax; N06AX02; TRP-01; Lyphan; trofan; L-Trp; Kalma; 2a4m; Htrp; 1qaw; trp; W; (S)-α-Amino-β-(3-indolyl)-propionic acid; 3-beta-Indolylalanine; Tryptophan; (±)-Tryptophan



数据库引用编号

71 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(6)

PlantCyc(0)

代谢反应

45 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(15)

WikiPathways(7)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(22)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wan-Zhen Li, Zi-Liang Song, Jun-le Li, Jia-Hui Yu, Du-Jian Deng, Xiao-Qing Cai, Martin J T Reaney, Zi-Zhe Cai, Yong Wang. Stability of tryptophan-containing LOs in flaxseed oil and their response towards γ-tocopherol. Food chemistry. 2024 Aug; 448(?):139026. doi: 10.1016/j.foodchem.2024.139026. [PMID: 38531298]
  • Xiaohong Wang, Jiawei Zhou, Tianlin Jiang, Jun Xu. Deciphering the therapeutic potential of SheXiangXinTongNing: Interplay between gut microbiota and brain metabolomics in a CUMS mice model, with a focus on tryptophan metabolism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155584. doi: 10.1016/j.phymed.2024.155584. [PMID: 38704913]
  • Ryo Hisada, Michihito Kono. Potential therapies targeting metabolic pathways in systemic lupus erythematosus. Clinical immunology (Orlando, Fla.). 2024 Jun; 263(?):110224. doi: 10.1016/j.clim.2024.110224. [PMID: 38648959]
  • Yue Zhang, Jing Li, Hongwei Yang, Kun Li, Haolin Yuan, Ziqiao Xue, Liangfu Tang, Zhijin Fan. Fungicidal Activity of New Pyrrolo[2,3-d]thiazoles and Their Potential Action on the Tryptophan Metabolic Pathway and Wax Biosynthesis. Journal of agricultural and food chemistry. 2024 May; 72(21):11990-12002. doi: 10.1021/acs.jafc.4c00930. [PMID: 38757490]
  • Tian-Ji Xia, Su-Wei Jin, Yong-Guang Liu, Shan-Shan Zhang, Zhi Wang, Xin-Min Liu, Rui-Le Pan, Ning Jiang, Yong-Hong Liao, Ming-Zhu Yan, Qi Chang. Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice. Journal of ethnopharmacology. 2024 May; 326(?):117992. doi: 10.1016/j.jep.2024.117992. [PMID: 38428654]
  • Yahui Zhang, Luoxia Han, Jiaqi Dong, Ziwen Yuan, Wanling Yao, Peng Ji, Yongli Hua, Yanming Wei. Shaoyao decoction improves damp-heat colitis by activating the AHR/IL-22/STAT3 pathway through tryptophan metabolism driven by gut microbiota. Journal of ethnopharmacology. 2024 May; 326(?):117874. doi: 10.1016/j.jep.2024.117874. [PMID: 38342152]
  • Alexandra Nefedova, Fredric G Svensson, Alexander S Vanetsev, Peter Agback, Tatiana Agback, Suresh Gohil, Lars Kloo, Tanel Tätte, Angela Ivask, Gulaim A Seisenbaeva, Vadim G Kessler. Molecular Mechanisms in Metal Oxide Nanoparticle-Tryptophan Interactions. Inorganic chemistry. 2024 May; 63(19):8556-8566. doi: 10.1021/acs.inorgchem.3c03674. [PMID: 38684718]
  • Meng-Yao Ma, Li-Li Hu, Wen-Yan Xu, Wei Zhang. L-tryptophan anaerobic fermentation for indole acetic acid production: Bacterial enrichment and effects of zero valent iron. Bioresource technology. 2024 May; 400(?):130691. doi: 10.1016/j.biortech.2024.130691. [PMID: 38599347]
  • Xiaoju Ding, Yunjie Jin, Xiaokai Shi, Yidi Wang, Zhibo Jin, Lei Yin, Shenglin Gao, Yibo Lei, Jinjian Yang. TDO2 promotes bladder cancer progression via AhR-mediated SPARC/FILIP1L signaling. Biochemical pharmacology. 2024 May; 223(?):116172. doi: 10.1016/j.bcp.2024.116172. [PMID: 38552852]
  • Yuguo Niu, Xiaoming Hu, Yali Song, Cunchuan Wang, Peixiang Luo, Shihong Ni, Fuxin Jiao, Ju Qiu, Weihong Jiang, Sheng Yang, Jun Chen, Rui Huang, Haizhou Jiang, Shanghai Chen, Qiwei Zhai, Jia Xiao, Feifan Guo. Blautia Coccoides is a Newly Identified Bacterium Increased by Leucine Deprivation and has a Novel Function in Improving Metabolic Disorders. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024 May; 11(18):e2309255. doi: 10.1002/advs.202309255. [PMID: 38429906]
  • Qianqian Xiang, Zhujun Wang, Jinzhan Yan, Minmin Niu, Wenyu Long, Zhihao Ju, Xuexiu Chang. Metabolomic analysis to understand the mechanism of Ti3C2Tx (MXene) toxicity in Daphnia magna. Aquatic toxicology (Amsterdam, Netherlands). 2024 May; 270(?):106904. doi: 10.1016/j.aquatox.2024.106904. [PMID: 38513426]
  • Yeon-Hee Kim, Jin-Soo Chung, Hyung-Ho Lee, Jin-Hee Park, Mi-Kyung Kim. Influence of Dietary Polyunsaturated Fatty Acid Intake on Potential Lipid Metabolite Diagnostic Markers in Renal Cell Carcinoma: A Case-Control Study. Nutrients. 2024 Apr; 16(9):. doi: 10.3390/nu16091265. [PMID: 38732512]
  • Magdalena Wróbel-Kwiatkowska, Waldemar Turski, Grażyna Silska, Magdalena Rakicka-Pustułka, Lucyna Dymińska, Waldemar Rymowicz. Determination of Bioactive Compound Kynurenic Acid in Linum usitatissimum L. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081702. [PMID: 38675522]
  • Er Jin, Zhidong Yin, Xiuxiu Zheng, Chenhong Yan, Kai Xu, Fouejio Yemele Eunice, Yue Gao. Potential of Targeting TDO2 as the Lung Adenocarcinoma Treatment. Journal of proteome research. 2024 Apr; 23(4):1341-1350. doi: 10.1021/acs.jproteome.3c00746. [PMID: 38421152]
  • Chun Chu, Shengquan Liu, Liangui Nie, Hongming Hu, Yi Liu, Jun Yang. The interactions and biological pathways among metabolomics products of patients with coronary heart disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116305. doi: 10.1016/j.biopha.2024.116305. [PMID: 38422653]
  • Aurélie Hanin, Céline Chollet, Sophie Demeret, Lucas Di Meglio, Florence Castelli, Vincent Navarro. Metabolomic changes in adults with status epilepticus: A human case-control study. Epilepsia. 2024 Apr; 65(4):929-943. doi: 10.1111/epi.17899. [PMID: 38339978]
  • Xiurong Chen, Xiaoyun Ye, Xiao Yu, Jiamin Zhao, Meijing Song, Danning Yin, Jiayu Yu. Analysis of the regulatory mechanism of exogenous IAA-mediated tryptophan accumulation and synthesis of endogenous IAA in Chlorococcum humicola. Chemosphere. 2024 Apr; 354(?):141633. doi: 10.1016/j.chemosphere.2024.141633. [PMID: 38442772]
  • Suvi T Itkonen, Juliane Calvez, Gheorghe Airinei, Martin Chapelais, Nadezda Khodorova, Moulay Sahaka, Robert Benamouzig, Frederick L Stoddard, Asko Simojoki, Anne-Maria Pajari, Claire Gaudichon. True Ileal Amino Acid Digestibility and Protein Quality of 15N-Labeled Faba Bean in Healthy Humans. The Journal of nutrition. 2024 Apr; 154(4):1165-1174. doi: 10.1016/j.tjnut.2024.01.030. [PMID: 38311065]
  • Yingjie Qin, Jiayi Chen, Dali Qian, Zhongyu Li, Licong Zhang, Qingquan Ma. Excessive Tryptophan and Phenylalanine Induced Pancreatic Injury and Glycometabolism Disorder in Grower-finisher Pigs. The Journal of nutrition. 2024 Apr; 154(4):1333-1346. doi: 10.1016/j.tjnut.2024.01.019. [PMID: 38582698]
  • Sara Leite Dias, Ling Chuang, Shenyu Liu, Benedikt Seligmann, Fabian L Brendel, Benjamin G Chavez, Robert E Hoffie, Iris Hoffie, Jochen Kumlehn, Arne Bültemeier, Johanna Wolf, Marco Herde, Claus-Peter Witte, John C D'Auria, Jakob Franke. Biosynthesis of the allelopathic alkaloid gramine in barley by a cryptic oxidative rearrangement. Science (New York, N.Y.). 2024 Mar; 383(6690):1448-1454. doi: 10.1126/science.adk6112. [PMID: 38547266]
  • Ling-Ling Qin, Meng Yu, Peng Yang, Zhong-Mei Zou. The rhizomes of Atractylodes macrocephala relieve loperamide-induced constipation in rats by regulation of tryptophan metabolism. Journal of ethnopharmacology. 2024 Mar; 322(?):117637. doi: 10.1016/j.jep.2023.117637. [PMID: 38135226]
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