4-hydroxyphenylacetate (BioDeep_00000000855)

 

Secondary id: BioDeep_00000265138, BioDeep_00000419023, BioDeep_00000862189

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


2-(4-hydroxyphenyl)acetic acid

化学式: C8H8O3 (152.0473)
中文名称: 对羟基苯乙酸, 4-羟基苯乙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 18.29%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

4-hydroxyphenylacetate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/4-hydroxyphenylacetate (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000000855). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC(=CC=C1CC(=O)O)O
InChI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)

描述信息

p-Hydroxyphenylacetic acid, also known as 4-hydroxybenzeneacetate, is classified as a member of the 1-hydroxy-2-unsubstituted benzenoids. 1-Hydroxy-2-unsubstituted benzenoids are phenols that are unsubstituted at the 2-position. p-Hydroxyphenylacetic acid is considered to be slightly soluble (in water) and acidic.  p-Hydroxyphenylacetic acid can be synthesized from acetic acid. It is also a parent compound for other transformation products, including but not limited to, methyl 2-(4-hydroxyphenyl)acetate, ixerochinolide, and lactucopicrin 15-oxalate.  p-Hydroxyphenylacetic acid can be found in numerous foods such as olives, cocoa beans, oats, and mushrooms. p-Hydroxyphenylacetic acid can be found throughout all human tissues and in all biofluids. Within a cell, p-hydroxyphenylacetic acid is primarily located in the cytoplasm and in the extracellular space. p-Hydroxyphenylacetic acid is also a microbial metabolite produced by Acinetobacter, Clostridium, Klebsiella, Pseudomonas, and Proteus. Higher levels of this metabolite are associated with an overgrowth of small intestinal bacteria from Clostridia species including C. difficile, C. stricklandii, C. lituseburense, C. subterminale, C. putrefaciens, and C. propionicum (PMID: 476929, 12173102). p-Hydroxyphenylacetic acid is detected after the consumption of whole grain.
4-hydroxyphenylacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. It has a role as a plant metabolite, a fungal metabolite, a human metabolite and a mouse metabolite. It is a monocarboxylic acid and a member of phenols. It is functionally related to an acetic acid. It is a conjugate acid of a 4-hydroxyphenylacetate.
4-Hydroxyphenylacetic acid is a natural product found in Guanomyces polythrix, Forsythia suspensa, and other organisms with data available.
4-Hydroxyphenylacetic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.
Constituent of sweet clover (Melilotus officinalis) and yeast

Hydroxyphenylacetic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=156-38-7 (retrieved 2024-07-02) (CAS RN: 156-38-7). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].

同义名列表

63 个代谢物同义名

InChI=1/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11; 4-Hydroxyphenylacetic acid, Vetec(TM) reagent grade, 98\\%; 4-10-00-00543 (Beilstein Handbook Reference); 2-[4-(hydroxy)phenyl)acetic acid; 4-Hydroxyphenylacetic acid, 98\\%; 2-(4-(HYDROXY)PHENYL)ACETIC ACID; Acetic acid, (p-hydroxyphenyl)-; (4-Hydroxy-phenyl)-essigsaeure; (4-hydroxy-phenyl)-acetic acid; (4-hydroxyphenyl)ethanoic acid; 2-(4-hydroxyphenyl)acetic acid; benzeneacetic acid, 4-hydroxy-; 4-Hydroxyphenylacetic Acid,(S); (4-hydroxyphenyl)-acetic acid; Acetic acid, 4-hydroxyphenyl-; Parahydroxy phenylacetic acid; (p-hydroxyphenyl)-Acetic acid; (4-hydroxyphenyl) acetic acid; para-hydroxyphenylacetic acid; p-hydroxy phenyl acetic acid; 4-hydroxy-phenyl acetic acid; (4-Hydroxyphenyl)acetic acid; 4-Hydroxybenzene acetic acid; 4-Hydroxy-Benzeneacetic acid; 4-hydroxyphenylethanoic acid; (p-Hydroxyphenyl)acetic acid; 4-hydroxy phenyl acetic acid; 4- hydroxyphenylacetic acid; 4-Hydroxybenzeneacetic acid; 4-Hydroxyphenyl acetic acid; p-Hydroxyphenyl acetic acid; 4-hydroxyphenyl-acetic acid; 4-hydroxy-phenylacetic acid; (4-hydroxy-phenyl)-acetate; 4-Hydroxyphenylacetic acid; p-hydroxyphenylacetic acid; 4-hyroxyphenylacetic acid; Parahydroxy phenylacetate; (p-hydroxyphenyl)-Acetate; 4-hydroxyphenyacetic acid; 4-hydroxyphenylactic acid; (4-Hydroxyphenyl)acetate; 4-Hydroxy-Benzeneacetate; Parahydroxyphenylacetate; (p-hydroxyphenyl)acetate; 4-hydroxybenzeneacetate; 4-(Carboxymethyl)phenol; p-hydroxyphenylacetate; 4-hydroxyphenylacetate; 4-Carboxymethylphenol; UNII-3J9SHG0RCN; ChemDiv3_005483; IDI1_023393; 3J9SHG0RCN; AI3-17755; 4-HPA; 3pcg; HPAA; 1ai6; 4HP; 4-Hydroxyphenylacetic acid; p-Hydroxyphenylacetic acid; 4-Hydroxyphenylacetate



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

29 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(2)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(24)

PharmGKB(0)

215 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, BLVRB, CAT, POMC, TH, TYR
Peripheral membrane protein 1 HSD17B6
Endosome membrane 1 HLA-DRB1
Endoplasmic reticulum membrane 2 CD4, HLA-DRB1
Nucleus 4 ALB, MPO, S100A8, TH
cytosol 7 ALB, BLVRB, CAT, HGD, LIPE, S100A8, TH
dendrite 2 C4A, TH
centrosome 1 ALB
nucleoplasm 2 BLVRB, MPO
Cell membrane 3 CD4, HLA-DRB1, LIPE
Cell projection, axon 2 C4A, TH
Early endosome membrane 2 HLA-DRB1, HSD17B6
Synapse 2 C4A, CRH
cell surface 1 HLA-DRB1
Golgi apparatus 1 ALB
Golgi membrane 1 HLA-DRB1
lysosomal membrane 1 HLA-DRB1
neuronal cell body 1 C4A
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Cytoplasm, cytosol 1 LIPE
Lysosome 2 MPO, TYR
plasma membrane 7 BLVRB, C4A, CD4, HLA-DRB1, IFNLR1, LTB, S100A8
terminal bouton 1 TH
Membrane 5 CAT, HLA-DRB1, IFNLR1, LIPE, LTB
axon 2 C4A, TH
caveola 1 LIPE
extracellular exosome 8 ALB, BLVRB, C4A, CAT, HGD, HLA-DRB1, MPO, S100A8
Lysosome membrane 1 HLA-DRB1
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 ALB, HSD17B6
extracellular space 11 ALB, C4A, CRH, HLA-DRB1, IL17A, IL4, IL6, LTB, MPO, POMC, S100A8
perinuclear region of cytoplasm 2 TH, TYR
mitochondrion 2 CAT, TH
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 5 BLVRB, CAT, HSD17B6, MPO, TYR
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 4 CD4, HLA-DRB1, IFNLR1, TYR
Secreted 7 ALB, C4A, CRH, IL17A, IL4, IL6, POMC
extracellular region 10 ALB, C4A, CAT, CRH, IL17A, IL4, IL6, MPO, POMC, S100A8
cytoplasmic side of plasma membrane 1 TH
Single-pass membrane protein 1 HLA-DRB1
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
external side of plasma membrane 3 CD4, HLA-DRB1, IL17A
varicosity 1 CRH
neuronal dense core vesicle lumen 1 CRH
perikaryon 2 CRH, TH
cytoplasmic vesicle 1 TH
Melanosome membrane 2 TH, TYR
Early endosome 1 CD4
Golgi-associated vesicle 1 TYR
Single-pass type II membrane protein 1 LTB
Cytoplasm, perinuclear region 1 TH
Membrane raft 1 CD4
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 S100A8
secretory granule 2 MPO, POMC
intermediate filament 1 HLA-DRB1
neuron projection 1 TH
ciliary basal body 1 ALB
Late endosome membrane 1 HLA-DRB1
phagocytic vesicle membrane 1 HLA-DRB1
cytoskeleton 1 S100A8
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, C4A
Recycling endosome membrane 1 HLA-DRB1
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cell projection, dendrite 1 C4A
Melanosome 1 TYR
intermediate filament cytoskeleton 1 S100A8
azurophil granule 1 MPO
trans-Golgi network membrane 1 HLA-DRB1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, POMC, S100A8
endoplasmic reticulum lumen 4 ALB, C4A, CD4, IL6
platelet alpha granule lumen 1 ALB
endocytic vesicle membrane 1 HLA-DRB1
azurophil granule lumen 1 MPO
immunological synapse 1 HLA-DRB1
ER to Golgi transport vesicle membrane 1 HLA-DRB1
clathrin-coated endocytic vesicle membrane 2 CD4, HLA-DRB1
phagocytic vesicle lumen 1 MPO
lumenal side of endoplasmic reticulum membrane 1 HLA-DRB1
T cell receptor complex 1 CD4
Autolysosome membrane 1 HLA-DRB1
MHC class II protein complex 1 HLA-DRB1
transport vesicle membrane 1 HLA-DRB1
catalase complex 1 CAT
calprotectin complex 1 S100A8
interleukin-6 receptor complex 1 IL6
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Shaoshuai Xin, Mengqi Zhang, Peihai Li, Lizhen Wang, Xuanming Zhang, Shanshan Zhang, Zhenqiang Mu, Houwen Lin, Xiaobin Li, Kechun Liu. Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish. Marine drugs. 2024 Mar; 22(4):. doi: 10.3390/md22040148. [PMID: 38667765]
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  • Yu-Ping Shen, Yuyang Pan, Fu-Xing Niu, Yu-Ling Liao, Mingtao Huang, Jian-Zhong Liu. Biosensor-assisted evolution for high-level production of 4-hydroxyphenylacetic acid in Escherichia coli. Metabolic engineering. 2022 03; 70(?):1-11. doi: 10.1016/j.ymben.2021.12.008. [PMID: 34965469]
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