canthaxanthin (BioDeep_00000638840)

Main id: BioDeep_00000003723

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


canthaxanthin

化学式: C40H52O2 (564.3967)
中文名称: 斑蝥黄(反式)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C(=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C(=O)CCC1(C)C)/C=C/C=C(\C)/C=C/C1=C(C)C(=O)CCC1(C)C
InChI: InChI=1S/C40H52O2/c1-29(17-13-19-31(3)21-23-35-33(5)37(41)25-27-39(35,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-36-34(6)38(42)26-28-40(36,9)10/h11-24H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+

描述信息

A carotenone that consists of beta,beta-carotene bearing two oxo substituents at positions 4 and 4.
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids

同义名列表

2 个代谢物同义名

canthaxanthin; Canthaxanthin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

314 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 BCL2, CASP3, CAT, CYP1A1, GJA1, HPGDS, ODC1, RARB, TLX2, TP53
Peripheral membrane protein 1 CYP1A1
Endoplasmic reticulum membrane 4 BCL2, CYP1A1, GJA1, UGT1A1
Nucleus 6 BCL2, CASP3, GJA1, RARB, TLX2, TP53
cytosol 9 BCL2, CASP3, CAT, GJA1, GPT, GSR, HPGDS, ODC1, TP53
centrosome 1 TP53
nucleoplasm 5 CASP3, GJA1, HPGDS, RARB, TP53
Cell membrane 3 GJA1, SLC6A8, TNF
Multi-pass membrane protein 3 GJA1, RHO, SLC6A8
cell junction 1 GJA1
cell surface 3 ENPP1, EPO, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 GJA1, RHO
Golgi membrane 2 GJA1, RHO
lysosomal membrane 1 ENPP1
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 2 CASP3, TNF
plasma membrane 6 ENPP1, GJA1, RHO, SLC6A8, TNF, UGT1A1
Membrane 7 BCL2, CAT, ENPP1, RHO, SLC6A8, TP53, UGT1A1
apical plasma membrane 2 GJA1, SLC6A8
basolateral plasma membrane 1 ENPP1
extracellular exosome 4 CAT, EPO, GPT, GSR
endoplasmic reticulum 4 BCL2, GJA1, TP53, UGT1A1
extracellular space 4 ENPP1, EPO, IL2, TNF
perinuclear region of cytoplasm 1 UGT1A1
gap junction 1 GJA1
intercalated disc 1 GJA1
mitochondrion 6 BCL2, CAT, CYP1A1, GJA1, GSR, TP53
protein-containing complex 3 BCL2, CAT, TP53
intracellular membrane-bounded organelle 4 CAT, CYP1A1, GJA1, HPGDS
Microsome membrane 1 CYP1A1
postsynaptic density 1 CASP3
Secreted 3 ENPP1, EPO, IL2
extracellular region 4 CAT, EPO, IL2, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, UGT1A1
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 TP53
mitochondrial matrix 3 CAT, GSR, TP53
transcription regulator complex 1 TP53
ciliary membrane 1 RHO
photoreceptor inner segment 1 RHO
photoreceptor outer segment 1 RHO
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 GSR, TNF
nucleolus 1 TP53
cell-cell junction 1 RHO
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 SLC6A8
Cytoplasm, perinuclear region 1 UGT1A1
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 2 GJA1, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 CAT, GJA1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
Cell junction, gap junction 1 GJA1
connexin complex 1 GJA1
contractile muscle fiber 1 GJA1
fascia adherens 1 GJA1
intermediate filament 1 GJA1
lateral plasma membrane 1 GJA1
chromatin 3 RARB, TLX2, TP53
phagocytic cup 1 TNF
Cell projection, cilium, photoreceptor outer segment 1 RHO
sperm midpiece 1 RHO
Basolateral cell membrane 1 ENPP1
site of double-strand break 1 TP53
Golgi-associated vesicle membrane 2 GJA1, RHO
cell body 1 EPO
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, EPO
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
Photoreceptor inner segment membrane 1 RHO
tight junction 1 GJA1
[Isoform 1]: Nucleus 1 TP53
death-inducing signaling complex 1 CASP3
photoreceptor outer segment membrane 1 RHO
sperm head plasma membrane 1 RHO
cell-cell contact zone 1 GJA1
photoreceptor disc membrane 1 RHO
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 UGT1A1
rod photoreceptor outer segment 1 RHO
BAD-BCL-2 complex 1 BCL2
cytochrome complex 1 UGT1A1
[Ectonucleotide pyrophosphatase/phosphodiesterase family member 1]: Cell membrane 1 ENPP1
[Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted 1 ENPP1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Paul V Sauer, Lorenzo Cupellini, Markus Sutter, Mattia Bondanza, María Agustina Domínguez Martin, Henning Kirst, David Bína, Adrian Fujiet Koh, Abhay Kotecha, Basil J Greber, Eva Nogales, Tomáš Polívka, Benedetta Mennucci, Cheryl A Kerfeld. Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes. Science advances. 2024 Apr; 10(14):eadk7535. doi: 10.1126/sciadv.adk7535. [PMID: 38578996]
  • Justin B Rose, José A Gascón, Markus Sutter, Damien I Sheppard, Cheryl A Kerfeld, Warren F Beck. Photoactivation of the orange carotenoid protein requires two light-driven reactions mediated by a metastable monomeric intermediate. Physical chemistry chemical physics : PCCP. 2023 Dec; 25(48):33000-33012. doi: 10.1039/d3cp04484j. [PMID: 38032096]
  • Kristina Likkei, Marcus Moldenhauer, Neslihan N Tavraz, Eugene G Maksimov, Nikolai N Sluchanko, Thomas Friedrich. Lipid composition and properties affect protein-mediated carotenoid uptake efficiency from membranes. Biochimica et biophysica acta. Biomembranes. 2023 Oct; ?(?):184241. doi: 10.1016/j.bbamem.2023.184241. [PMID: 37866690]
  • Rudy Kurniawan, Fahrul Nurkolis, Nurpudji Astuti Taslim, Dionysius Subali, Reggie Surya, William Ben Gunawan, Darmawan Alisaputra, Nelly Mayulu, Netty Salindeho, Bonglee Kim. Carotenoids Composition of Green Algae Caulerpa racemosa and Their Antidiabetic, Anti-Obesity, Antioxidant, and Anti-Inflammatory Properties. Molecules (Basel, Switzerland). 2023 Apr; 28(7):. doi: 10.3390/molecules28073267. [PMID: 37050034]
  • Jie Zhou, Jiahui Guo, Qingsheng Chen, Baosong Wang, Xudong He, Qiang Zhuge, Pu Wang. Different color regulation mechanism in willow barks determined using integrated metabolomics and transcriptomics analyses. BMC plant biology. 2022 Nov; 22(1):530. doi: 10.1186/s12870-022-03909-x. [PMID: 36380271]
  • Paweł Żbik, Przemysław Malec. The occurrence of the cis/trans geometric isomerism of myxoxanthophyll and 4-ketomyxoxanthophyll in the cyanobacterium Anabaena sp. PCC7120. Acta biochimica Polonica. 2022 Aug; 69(3):523-529. doi: 10.18388/abp.2020_6449. [PMID: 36041059]
  • Fawzy Ismail, Khalil Sherif, Yasser Rizk, Montaha Hassan, Aml Mekawy, Khalid Mahrose. Dietary supplementation of spirulina and canthaxanthin boosts laying performance, lipid profile in blood and egg yolk, hatchability, and semen quality of chickens. Journal of animal physiology and animal nutrition. 2022 May; ?(?):. doi: 10.1111/jpn.13729. [PMID: 35534942]
  • Jisong Ahn, Min Jung Kim, Ahyoung Yoo, Jiyun Ahn, Tae Youl Ha, Chang Hwa Jung, Hyo Deok Seo, Young Jin Jang. Identifying Codium fragile extract components and their effects on muscle weight and exercise endurance. Food chemistry. 2021 Aug; 353(?):129463. doi: 10.1016/j.foodchem.2021.129463. [PMID: 33743428]
  • Andrew J Hambly, Jeroen S van Duijneveldt, Paul J Gates. Identification of β-carotene oxidation products produced by bleaching clay using UPLC-ESI-MS/MS. Food chemistry. 2021 Aug; 353(?):129455. doi: 10.1016/j.foodchem.2021.129455. [PMID: 33711704]
  • Ahila Mathimaran, Anbarasu Kumar, Gurudayal Prajapati, Ravi S Ampapathi, Himangsu K Bora, Rajdeep Guha. Partially saturated canthaxanthin alleviates aging-associated oxidative stress in D-galactose administered male wistar rats. Biogerontology. 2021 02; 22(1):19-34. doi: 10.1007/s10522-020-09898-4. [PMID: 32926226]
  • L P Bonagurio, F K Cruz, I N Kaneko, P T Matumoto-Pintro, A E Murakami, T C Santos. Dietary supplementation with canthaxanthin and 25-hydroxycholecalciferol has beneficial effects on bone and oxidative metabolism in European quail breeders. Poultry science. 2020 Oct; 99(10):4874-4883. doi: 10.1016/j.psj.2020.06.021. [PMID: 32988524]
  • Maria Agustina Dominguez-Martin, Michal Hammel, Sayan Gupta, Sigal Lechno-Yossef, Markus Sutter, Daniel J Rosenberg, Yan Chen, Christopher J Petzold, Corie Y Ralston, Tomáš Polívka, Cheryl A Kerfeld. Structural analysis of a new carotenoid-binding protein: the C-terminal domain homolog of the OCP. Scientific reports. 2020 09; 10(1):15564. doi: 10.1038/s41598-020-72383-y. [PMID: 32968135]
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  • Kantima Janchot, Monrawat Rauytanapanit, Masaki Honda, Takashi Hibino, Sophon Sirisattha, Thanit Praneenararat, Hakuto Kageyama, Rungaroon Waditee-Sirisattha. Effects of Potassium Chloride-Induced Stress on the Carotenoids Canthaxanthin, Astaxanthin, and Lipid Accumulations in the Green Chlorococcal Microalga Strain TISTR 9500. The Journal of eukaryotic microbiology. 2019 09; 66(5):778-787. doi: 10.1111/jeu.12726. [PMID: 30854724]
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  • Maria Agustina Dominguez-Martin, Tomáš Polívka, Markus Sutter, Bryan Ferlez, Sigal Lechno-Yossef, Beronda L Montgomery, Cheryl A Kerfeld. Structural and spectroscopic characterization of HCP2. Biochimica et biophysica acta. Bioenergetics. 2019 05; 1860(5):414-424. doi: 10.1016/j.bbabio.2019.03.004. [PMID: 30880081]
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  • Qinlong Zhu, Dongchang Zeng, Suize Yu, Chaojun Cui, Jiamin Li, Heying Li, Junyu Chen, Runzhao Zhang, Xiucai Zhao, Letian Chen, Yao-Guang Liu. From Golden Rice to aSTARice: Bioengineering Astaxanthin Biosynthesis in Rice Endosperm. Molecular plant. 2018 12; 11(12):1440-1448. doi: 10.1016/j.molp.2018.09.007. [PMID: 30296601]
  • Kenshi Watanabe, Kim Hazel V Arafiles, Risa Higashi, Yoshiko Okamura, Takahisa Tajima, Yukihiko Matsumura, Yutaka Nakashimada, Keisuke Matsuyama, Tsunehiro Aki. Isolation of High Carotenoid-producing Aurantiochytrium sp. Mutants and Improvement of Astaxanthin Productivity Using Metabolic Information. Journal of oleo science. 2018 May; 67(5):571-578. doi: 10.5650/jos.ess17230. [PMID: 29628484]
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  • Fernando Muzzopappa, Adjélé Wilson, Vinosa Yogarajah, Sandrine Cot, François Perreau, Cédric Montigny, Céline Bourcier de Carbon, Diana Kirilovsky. Paralogs of the C-Terminal Domain of the Cyanobacterial Orange Carotenoid Protein Are Carotenoid Donors to Helical Carotenoid Proteins. Plant physiology. 2017 Nov; 175(3):1283-1303. doi: 10.1104/pp.17.01040. [PMID: 28935842]
  • Helder M Souza, Lúcia C P Arruda, Millena M Monteiro, Igor H A V Nery, Robespierre A J Araújo Silva, André M Batista, Maria Madalena Pessoa Guerra. The Effect of Canthaxanthin on the Quality of Frozen Ram Spermatozoa. Biopreservation and biobanking. 2017 Jun; 15(3):220-227. doi: 10.1089/bio.2016.0049. [PMID: 28005396]
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  • A P Rosa, C E V Bonilla, A Londero, C B S Giacomini, C Orso, M O Fernandes, J S Moura, R Hermes. Effect of broiler breeders fed with corn or sorghum and canthaxanthin on lipid peroxidation, fatty acid profile of hatching eggs, and offspring performance. Poultry science. 2017 Mar; 96(3):647-658. doi: 10.3382/ps/pew294. [PMID: 27601683]
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  • Yu Fen Zheng, Jee Sun Min, Doyun Kim, Jung Bae Park, Sung-Wook Choi, Eun Seong Lee, Kun Na, Soo Kyung Bae. In Vitro Inhibition of Human UDP-Glucuronosyl-Transferase (UGT) Isoforms by Astaxanthin, β-Cryptoxanthin, Canthaxanthin, Lutein, and Zeaxanthin: Prediction of in Vivo Dietary Supplement-Drug Interactions. Molecules (Basel, Switzerland). 2016 Aug; 21(8):. doi: 10.3390/molecules21081052. [PMID: 27529203]
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  • Ryan L Leverenz, Markus Sutter, Adjélé Wilson, Sayan Gupta, Adrien Thurotte, Céline Bourcier de Carbon, Christopher J Petzold, Corie Ralston, François Perreau, Diana Kirilovsky, Cheryl A Kerfeld. PHOTOSYNTHESIS. A 12 Å carotenoid translocation in a photoswitch associated with cyanobacterial photoprotection. Science (New York, N.Y.). 2015 Jun; 348(6242):1463-6. doi: 10.1126/science.aaa7234. [PMID: 26113721]
  • Shuqin Xia, Chen Tan, Yating Zhang, Shabbar Abbas, Biao Feng, Xiaoming Zhang, Fang Qin. Modulating effect of lipid bilayer-carotenoid interactions on the property of liposome encapsulation. Colloids and surfaces. B, Biointerfaces. 2015 Apr; 128(?):172-180. doi: 10.1016/j.colsurfb.2015.02.004. [PMID: 25747311]
  • S Kathiresan, Arun Chandrashekar, G A Ravishankar, R Sarada. Regulation of astaxanthin and its intermediates through cloning and genetic transformation of β-carotene ketolase in Haematococcus pluvialis. Journal of biotechnology. 2015 Feb; 196-197(?):33-41. doi: 10.1016/j.jbiotec.2015.01.006. [PMID: 25612872]
  • Emily C Pierce, Peter R LaFayette, María A Ortega, Blake L Joyce, Dean A Kopsell, Wayne A Parrott. Ketocarotenoid Production in Soybean Seeds through Metabolic Engineering. PloS one. 2015; 10(9):e0138196. doi: 10.1371/journal.pone.0138196. [PMID: 26376481]
  • Chen Tan, Jin Xue, Xiaowei Lou, Shabbar Abbas, Yu Guan, Biao Feng, Xiaoming Zhang, Shuqin Xia. Liposomes as delivery systems for carotenoids: comparative studies of loading ability, storage stability and in vitro release. Food & function. 2014 Jun; 5(6):1232-40. doi: 10.1039/c3fo60498e. [PMID: 24714683]
  • Borhane Samir Grama, Samira Chader, Douadi Khelifi, Spiros N Agathos, Clayton Jeffryes. Induction of canthaxanthin production in a Dactylococcus microalga isolated from the Algerian Sahara. Bioresource technology. 2014 Jan; 151(?):297-305. doi: 10.1016/j.biortech.2013.10.073. [PMID: 24262839]
  • Seyed Mohammad Taghi Gharibzahedi, Seyed Hadi Razavi, Seyed Mohammad Mousavi. Ultrasound-assisted formation of the canthaxanthin emulsions stabilized by arabic and xanthan gums. Carbohydrate polymers. 2013 Jul; 96(1):21-30. doi: 10.1016/j.carbpol.2013.03.085. [PMID: 23688450]
  • Takashi Maoka, Hiroyuki Yasui, Aya Ohmori, Harukuni Tokuda, Nobutaka Suzuki, Ayako Osawa, Kazutoshi Shindo, Takashi Ishibashi. Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin. Journal of oleo science. 2013; 62(3):181-6. doi: 10.5650/jos.62.181. [PMID: 23470446]
  • Seyed Mohammad Taghi Gharibzahedi, Seyed Hadi Razavi, Seyed Mohammad Mousavi. Developing an emulsion model system containing canthaxanthin biosynthesized by Dietzia natronolimnaea HS-1. International journal of biological macromolecules. 2012 Nov; 51(4):618-26. doi: 10.1016/j.ijbiomac.2012.06.030. [PMID: 22750576]
  • Baldo F Cordero, Inmaculada Couso, Rosa Leon, Herminia Rodriguez, Maria Angeles Vargas. Isolation and characterization of a lycopene ε-cyclase gene of Chlorella (Chromochloris) zofingiensis. Regulation of the carotenogenic pathway by nitrogen and light. Marine drugs. 2012 Sep; 10(9):2069-2088. doi: 10.3390/md10092069. [PMID: 23118722]
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  • Anbarasu Kumar, Akshatha Hosahalli Srikanta, Muthukumar Serva Peddha, Umesh-Kumar Sukumaran, Vijayalakshmi Govindaswamy. A short-term toxicity study of Aspergillus carbonarius carotenoid. International journal of toxicology. 2012 Mar; 31(2):158-65. doi: 10.1177/1091581811430402. [PMID: 22366116]
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  • Andreas Woelfelschneider, Odilia Popanda, Carmen Lilla, Jakob Linseisen, Claudia Mayer, Oktay Celebi, Jürgen Debus, Helmut Bartsch, Jenny Chang-Claude, Peter Schmezer. A distinct ERCC1 haplotype is associated with mRNA expression levels in prostate cancer patients. Carcinogenesis. 2008 Sep; 29(9):1758-64. doi: 10.1093/carcin/bgn067. [PMID: 18332046]
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  • Chun-Kuang Shih, Jui-Hung Chang, Shwu-Huey Yang, Tsui-Wei Chou, Hsing-Hsien Cheng. beta-Carotene and canthaxanthin alter the pro-oxidation and antioxidation balance in rats fed a high-cholesterol and high-fat diet. The British journal of nutrition. 2008 Jan; 99(1):59-66. doi: 10.1017/s0007114507781497. [PMID: 17640418]
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