NCBI Taxonomy: 111782
Tolypothrix (ncbi_taxid: 111782)
found 5 associated metabolites at genus taxonomy rank level.
Ancestor: Tolypothrichaceae
Child Taxonomies: Tolypothrix curta, Tolypothrix tenuis, Tolypothrix brevis, Tolypothrix nodosa, Tolypothrix fragilis, Tolypothrix carrinoi, Tolypothrix distorta, environmental samples, Tolypothrix bouteillei, Tolypothrix rechingeri, Tolypothrix pseudorexia, Tolypothrix fasciculata, unclassified Tolypothrix, Tolypothrix scytonemoides, Tolypothrix campylonemoides, [Scytonema hofmanni] UTEX B 1581
Toyocamycin
C12H13N5O4 (291.09674980000005)
An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group. D009676 - Noxae > D000963 - Antimetabolites D000970 - Antineoplastic Agents Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC50 value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC50 value of 79 nM[1][2][3].