Procyanidin A1 (BioDeep_00000228386)

Main id: BioDeep_00000004330

 

human metabolite PANOMIX_OTCML-2023 PANOMIX-Anthocyanidin natural product


代谢物信息卡片


5,13-bis(3,4-dihydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0²,¹¹.0³,⁸.0¹⁵,²⁰]henicosa-2,8,10,15,17,19-hexaene-6,9,17,19,21-pentol

化学式: C30H24O12 (576.1268)
中文名称: 原花青素A1, 原花青素A2
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(OC2=C1C(=CC3=C2C4C(C(O3)(OC5=CC(=CC(=C45)O)O)C6=CC(=C(C=C6)O)O)O)O)C7=CC(=C(C=C7)O)O)O
InChI: InChI=1S/C30H24O12/c31-13-7-20(37)24-22(8-13)41-30(12-2-4-16(33)19(36)6-12)29(39)26(24)25-23(42-30)10-17(34)14-9-21(38)27(40-28(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,21,26-27,29,31-39H,9H2

描述信息

Procyanidin a1 is a member of the class of compounds known as biflavonoids and polyflavonoids. Biflavonoids and polyflavonoids are organic compounds containing at least two flavan/flavone units. These units are usually linked through CC or C-O-C bonds. Some examples include C2-O-C3, C2-O-C4, C3-C3, and C6-C8. Procyanidin a1 is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Procyanidin a1 can be found in bilberry, which makes procyanidin a1 a potential biomarker for the consumption of this food product.
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects[1].
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects[1].

同义名列表

4 个代谢物同义名

5,13-bis(3,4-dihydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0²,¹¹.0³,⁸.0¹⁵,²⁰]henicosa-2,8,10,15,17,19-hexaene-6,9,17,19,21-pentol; proanthocyanidin A2; Procyanidin A1; Proanthocyanidin A1



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

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Plant Reactome(0)

INOH(0)

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104 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AIMP2, BECN1, DCTN4, KEAP1, MAPK8, MAPK9, MARVELD1, MTOR, PRKAA2, TLR4
Golgi apparatus, trans-Golgi network membrane 1 BECN1
Peripheral membrane protein 3 BECN1, GORASP1, MTOR
Endosome membrane 2 BECN1, TLR4
Endoplasmic reticulum membrane 3 BECN1, HMOX1, MTOR
Mitochondrion membrane 1 BECN1
Cytoplasmic vesicle, autophagosome 1 BECN1
Nucleus 11 AIMP2, BECN1, DCTN4, GABPA, HMOX1, KEAP1, MAPK8, MAPK9, MARVELD1, MTOR, PRKAA2
autophagosome 1 BECN1
cytosol 10 AIMP2, BECN1, DCTN4, HMOX1, KEAP1, MAPK8, MAPK9, MTOR, PRKAA2, PRKCQ
dendrite 3 BECN1, MTOR, PRKAA2
mitochondrial membrane 1 BECN1
nuclear body 1 BECN1
phagocytic vesicle 2 BECN1, MTOR
phosphatidylinositol 3-kinase complex, class III 1 BECN1
trans-Golgi network 1 BECN1
centrosome 1 DCTN4
nucleoplasm 7 GABPA, HMOX1, KEAP1, MAPK8, MAPK9, MTOR, PRKAA2
Cell membrane 5 CLDN1, MARVELD1, SELP, TLR4, TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
Multi-pass membrane protein 2 CLDN1, MARVELD1
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 1 MAPK8
cell cortex 1 DCTN4
cell surface 2 TLR4, TNF
Golgi apparatus 2 GORASP1, PRKAA2
Golgi membrane 3 GORASP1, INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 PRKAA2, TNF
Cytoplasm, cytosol 1 AIMP2
Lysosome 1 MTOR
endosome 1 BECN1
plasma membrane 8 CLDN1, IGHE, MAPK9, MARVELD1, PRKCQ, SELP, TLR4, TNF
Membrane 7 AIMP2, CLDN1, HMOX1, MARVELD1, MTOR, PRKAA2, TLR4
apical plasma membrane 1 CLDN1
axon 2 MAPK8, PRKAA2
basolateral plasma membrane 1 CLDN1
extracellular exosome 1 SELP
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BECN1, HMOX1, KEAP1
extracellular space 6 HMOX1, IGHE, IL4, INS, SELP, TNF
perinuclear region of cytoplasm 2 HMOX1, TLR4
Schaffer collateral - CA1 synapse 1 MAPK9
Cell junction, tight junction 1 CLDN1
bicellular tight junction 1 CLDN1
mitochondrion 1 MAPK9
protein-containing complex 1 CLDN1
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 3 IGHE, SELP, TLR4
Secreted 3 IL4, INS, SELP
extracellular region 5 IGHE, IL4, INS, SELP, TNF
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 2 HMOX1, MTOR
centriolar satellite 2 KEAP1, PRKCQ
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 DCTN4
external side of plasma membrane 3 SELP, TLR4, TNF
midbody 1 KEAP1
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 2 DCTN4, MARVELD1
focal adhesion 1 DCTN4
cis-Golgi network 1 GORASP1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
lateral plasma membrane 1 CLDN1
nuclear speck 2 MAPK9, PRKAA2
Cell projection, ruffle 1 TLR4
Cytoplasm, myofibril, sarcomere 1 DCTN4
ruffle 1 TLR4
sarcomere 1 DCTN4
receptor complex 1 TLR4
chromatin 1 GABPA
IgE immunoglobulin complex 1 IGHE
phagocytic cup 2 TLR4, TNF
cytoskeleton 1 MARVELD1
spindle pole 1 DCTN4
Cytoplasm, cell cortex 1 DCTN4
actin filament 1 KEAP1
Basolateral cell membrane 1 CLDN1
[Isoform 2]: Cell membrane 1 IGHE
Cul3-RING ubiquitin ligase complex 1 KEAP1
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
phagophore assembly site 1 BECN1
phosphatidylinositol 3-kinase complex, class III, type I 1 BECN1
phosphatidylinositol 3-kinase complex, class III, type II 1 BECN1
cytoplasmic stress granule 1 PRKAA2
stress fiber 1 DCTN4
platelet dense granule membrane 1 SELP
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
dynactin complex 1 DCTN4
kinetochore 1 DCTN4
transport vesicle 1 INS
tight junction 1 CLDN1
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
immunological synapse 1 PRKCQ
cytoplasmic dynein complex 1 DCTN4
aggresome 1 PRKCQ
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
Cytoplasm, cytoskeleton, stress fiber 1 DCTN4
basal dendrite 1 MAPK8
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
platelet alpha granule membrane 1 SELP
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
platelet dense granule lumen 1 SELP
inclusion body 1 KEAP1
cytoplasmic side of mitochondrial outer membrane 1 BECN1
[Beclin-1-C 35 kDa]: Mitochondrion 1 BECN1
[Beclin-1-C 37 kDa]: Mitochondrion 1 BECN1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Shan Han, Hongwei Gao, Shaoru Chen, Qinqin Wang, Xinxing Li, Li-Jun Du, Jun Li, Ying-Ying Luo, Jun-Xiu Li, Li-Chun Zhao, Jianfang Feng, Shilin Yang. Procyanidin A1 Alleviates Inflammatory Response induced by LPS through NF-κB, MAPK, and Nrf2/HO-1 Pathways in RAW264.7 cells. Scientific reports. 2019 10; 9(1):15087. doi: 10.1038/s41598-019-51614-x. [PMID: 31636354]
  • Yong Sui, Yan Zheng, Xiaopeng Li, Shuyi Li, Bijun Xie, Zhida Sun. Characterization and preparation of oligomeric procyanidins from Litchi chinensis pericarp. Fitoterapia. 2016 Jul; 112(?):168-74. doi: 10.1016/j.fitote.2016.06.001. [PMID: 27282208]
  • Keisuke Tomochika, Akiko Shimizu-Ibuka, Tomoko Tamura, Kiyoshi Mura, Naoki Abe, Jun-Ichi Onose, Soichi Arai. Effects of peanut-skin procyanidin A1 on degranulation of RBL-2H3 cells. Bioscience, biotechnology, and biochemistry. 2011; 75(9):1644-8. doi: 10.1271/bbb.110085. [PMID: 21897038]
  • Fumihide Takano, Takanobu Takata, Akio Yoshihara, Yuka Nakamura, Yukiko Arima, Tomihisa Ohta. Aqueous extract of peanut skin and its main constituent procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin. Biological & pharmaceutical bulletin. 2007 May; 30(5):922-7. doi: 10.1248/bpb.30.922. [PMID: 17473436]