Rosmarinic acid (BioDeep_00000000016)

Secondary id: BioDeep_00000017211, BioDeep_00000419325, BioDeep_00000869763

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite

代谢物信息卡片

BENZENEPROPANOIC ACID, .ALPHA.-(((2E)-3-(3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPEN-1-YL)OXY)-3,4-DIHYDROXY-, (.ALPHA.R)-

化学式: C18H16O8 (360.0845136)
中文名称: 迷迭香酸, 罗丹酚酸, 酪萨维, 肉桂醇甙, 迷迭香酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.51%

分子结构信息

SMILES: c1(c(ccc(c1)/C=C/C(=O)O[C@H](Cc1cc(c(cc1)O)O)C(=O)O)O)O
InChI: InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m0/s1

描述信息

Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. It is commonly found in species of the Boraginaceae and the subfamily Nepetoideae of the Lamiaceae. It is a red-orange powder that is slightly soluble in water, but well soluble is most organic solvents. Rosmarinic acid is one of the polyphenolic substances contained in culinary herbs such as perilla (Perilla frutescens L.), rosemary (Rosmarinus officinalis L.), sage (Salvia officinalis L.), mint (Mentha arvense L.), and basil (Ocimum basilicum L.). These herbs are commonly grown in the garden as kitchen herbs, and while used to add flavor in cooking, are also known to have several potent physiological effects (PMID: 12482446, 15120569). BioTransformer predicts that rosmarinic acid is a product of methylrosmarinic acid metabolism via a hydrolysis-of-carboxylic-acid-ester-pattern1 reaction occurring in humans and human gut microbiota and catalyzed by the liver carboxylesterase 1 (P23141) enzyme (PMID: 30612223).
(R)-rosmarinic acid is a stereoisomer of rosmarinic acid having (R)-configuration. It has a role as a plant metabolite and a geroprotector. It is a conjugate acid of a (R)-rosmarinate. It is an enantiomer of a (S)-rosmarinic acid.
Rosmarinic acid is a natural product found in Dimetia scandens, Scrophularia scorodonia, and other organisms with data available.
See also: Rosemary Oil (part of); Comfrey Root (part of); Holy basil leaf (part of) ... View More ...
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
Isolated from rosemary, mint, sage, thyme, lemon balm and other plants
D002491 - Central Nervous System Agents > D000700 - Analgesics
A stereoisomer of rosmarinic acid having (R)-configuration.
D020011 - Protective Agents > D000975 - Antioxidants
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Acquisition and generation of the data is financially supported in part by CREST/JST.
Rosmarinic acid is a widespread phenolic ester compound in the plants. Rosmarinic acid inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively.
Rosmarinic acid is a widespread phenolic ester compound in the plants. Rosmarinic acid inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively.

同义名列表

73 个代谢物同义名

数据库引用编号

40 个数据库交叉引用编号

ChEBI: CHEBI:92370
ChEBI: CHEBI:50371
ChEBI: CHEBI:50372
KEGG: C01850
PubChem: 5281792
PubChem: 639655
PubChem: 5099
HMDB: HMDB0003572
Metlin: METLIN3504
DrugBank: DB16865
ChEMBL: CHEMBL324842
ChEMBL: CHEMBL3098862
Wikipedia: Rosmarinic_acid
MeSH: rosmarinic acid
ChemIDplus: 0000537155
MetaCyc: CPD-6981
KNApSAcK: C00002770
foodb: FDB002427
chemspider: 4445104
CAS: 162281-84-7
CAS: 20283-92-5
CAS: 537-15-5
CAS: 179188-11-5
MoNA: PR040217
MoNA: PR040220
MoNA: PR040215
MoNA: PR040216
MoNA: PR040218
MoNA: PR040219
MoNA: PR100686
MoNA: PR040221
medchemexpress: HY-N0529
PMhub: MS000010042
MetaboLights: MTBLC50371
PubChem: 4967
PDB-CCD: ROA
3DMET: B01507
NIKKAJI: J15.542J
RefMet: Rosmarinic acid
RefMet: (S)-Rosmarinic acid

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

234 个相关的物种来源信息

126358 - Abeliophyllum distichum: 10.1016/S0031-9422(97)01134-5
115911 - Achatinella: 10.1016/J.PHYTOCHEM.2006.03.005
39269 - Agastache foeniculum: 10.1016/S0305-1978(99)00007-1
39270 - Agastache mexicana: 10.1016/S0305-1978(99)00007-1
39271 - Agastache rugosa:
268936 - Agastache urticifolia: 10.1016/S0305-1978(99)00007-1
167911 - Ajuga decumbens: 10.1248/YAKUSHI1947.106.12_1108
256470 - Anchusa azurea: 10.1002/HLCA.200900230
89630 - Anchusa officinalis:
256480 - Anchusa strigosa: 10.1016/J.PHYTOCHEM.2005.05.002
256480 - Anchusa strigosa: 10.1055/S-2003-43202
3234 - Anthoceros punctatus:
82398 - Apeiba tibourbou:
4217 - Arctium lappa: 10.1007/978-1-4613-1855-2_22
4217 - Arctium lappa: 10.1007/978-3-540-71095-0_1382
4217 - Arctium lappa: 10.1016/J.JPBA.2009.03.018
4217 - Arctium lappa: 10.1016/J.PHYMED.2009.04.005
4217 - Arctium lappa: 10.1016/S0031-9422(00)89550-3
4217 - Arctium lappa: 10.1248/BPB.19.1515
4217 - Arctium lappa: 10.1248/CPB.44.2300
120713 - Brainea insignis: 10.1248/CPB.58.868
197417 - Camonea umbellata: 10.3390/MOLECULES15118241
4628 - Canna indica: 10.1016/J.PHYTOCHEM.2004.06.003
48032 - Carum carvi: 10.1021/JF051513Y
489979 - Celastrus hindsii: 10.1021/JF052743F
1486496 - Centaurea arenaria: 10.1002/PTR.3187
363423 - Centaurea deflexa: 10.1016/J.EJMECH.2011.03.011
75648 - Centaurea imperialis: 10.1016/0031-9422(81)85287-9
41536 - Centaurea melitensis: 10.1016/J.PHYTOCHEM.2006.08.012
41536 - Centaurea melitensis: 10.1016/S0305-1978(01)00062-X
75633 - Centaurea nigra: 10.1016/S0305-1978(02)00227-2
145513 - Centaurea raphanina: 10.1590/S0102-695X2007000200003
363450 - Centaurea sclerolepis: 10.1177/1934578X0600100403
48106 - Centella asiatica: 10.1248/BPB.28.173
128608 - Cinnamomum verum: 10.1021/JF051513Y
85571 - Citrus reticulata Blanco: -
182371 - Clinopodium: 10.1021/NP800781T
516070 - Clinopodium chinense: 10.1021/NP800781T
751816 - Clinopodium umbrosum: 10.1002/JCCS.199300014
204180 - Coleus amboinicus: 10.1016/J.BMC.2014.01.009
4142 - Coleus scutellarioides:
986250 - Condea verticillata:
986250 - Condea verticillata: 10.1016/S0031-9422(00)97101-2
992840 - Cordia dichotoma: 10.1002/CBDV.201000058
163077 - Cordia sebestena: 10.1016/J.PHYTOCHEM.2010.09.008
222085 - Cordia sinensis: 10.3390/MOLECULES161210214
4047 - Coriandrum sativum: 10.1016/J.ARABJC.2013.12.011
298643 - Crataegus laevigata: 10.1515/ZNC-2001-9-1012
140997 - Crataegus monogyna: 10.1515/ZNC-2001-9-1012
510738 - Crataegus rhipidophylla: 10.1515/ZNC-2001-9-1012
52462 - Cuminum cyminum: 10.1021/JF051513Y
2753873 - Daphne feddei: 10.1021/NP8004166
2753873 - Daphne feddei: 10.1248/CPB.59.1421
1045991 - Dimetia scandens: 10.1016/J.BMCL.2012.12.077
39297 - Dracocephalum ruyschiana: 10.1016/S0305-1978(99)00007-1
263604 - Ehretia microphylla: 10.1016/0031-9422(94)00845-K
163084 - Ehretia monopyrena: 10.1016/0031-9422(94)00845-K
2811221 - Ehretia philippinensis: 10.1016/S0031-9422(00)97019-5
488675 - Eritrichium sericeum: 10.1055/S-2005-864141
205692 - Forsythia koreana: 10.1016/S0031-9422(00)83456-1
205692 - Forsythia koreana: 10.1016/S0031-9422(97)01134-5
205694 - Forsythia ovata: 10.1248/CPB.36.3667
126418 - Forsythia suspensa: 10.1002/RCM.2875
205691 - Forsythia viridissima: 10.1016/S0031-9422(00)83456-1
205691 - Forsythia viridissima: 10.1016/S0031-9422(97)01134-5
373155 - Gaillardia aestivalis: 10.1016/S0031-9422(00)95216-6
28509 - Glechoma hederacea:
28509 - Glechoma hederacea: 10.1016/J.BMCL.2011.02.002
516071 - Glechoma longituba: 10.1016/J.BMCL.2011.02.002
681445 - Hamelia patens: 10.1016/0031-9422(90)83076-D
2042402 - Hedeoma drummondii: 10.1089/JMF.2009.0041
4052 - Hedera helix:
85353 - Hedera hibernica: 10.1055/S-2006-957639
190244 - Helicteres angustifolia: 10.1016/J.PHYTOCHEM.2006.03.005
1382013 - Helicteres isora: 10.1016/J.PHYTOCHEM.2006.03.005
1382013 - Helicteres isora: 10.1248/CPB.47.1444
28508 - Heliotropium arborescens: 10.5511/PLANTBIOTECHNOLOGY1984.13.73
9606 - Homo sapiens: -
204124 - Hyptis capitata: 10.1016/0031-9422(91)85137-O
39324 - Hyssopus officinalis:
124778 - Illicium verum: 10.1021/JF051513Y
204131 - Isodon coetsa: 10.1016/J.PHYMED.2007.09.013
425908 - Isodon japonicus:
1504648 - Isodon oresbius:
662928 - Isodon sculponeatus: 10.1002/CHIN.200624175
4136 - Lamiaceae: 10.1038/SREP46252
85223 - Laurus nobilis: 10.1021/JF051513Y
39329 - Lavandula angustifolia: 10.1016/S0031-9422(00)80692-5
39329 - Lavandula angustifolia: 10.1016/S0305-1978(99)00007-1
34254 - Lithospermum erythrorhizon:
1720382 - Lycopus asper: 10.1007/BF02980102
1720382 - Lycopus asper: 10.1248/CPB.58.394
260603 - Lycopus europaeus:
516551 - Lycopus lucidus: 10.1007/BF02980102
516551 - Lycopus lucidus: 10.1248/CPB.58.394
1611021 - Meehania fargesii: 10.1248/CPB.58.696
672825 - Meehania urticifolia: 10.1248/CPB.59.88
39338 - Melissa officinalis:
292239 - Mentha arvensis: 10.1248/YAKUSHI1947.106.12_1108
29719 - Mentha spicata:
29719 - Mentha spicata: 10.1016/S0031-9422(97)01112-6
38860 - Mentha suaveolens: 10.1248/YAKUSHI1947.106.12_1108
3673 - Momordica charantia: 10.1055/S-2006-960072
182378 - Monarda bradburiana: 10.1016/S0305-1978(99)00007-1
182379 - Monarda citriodora: 10.1016/S0305-1978(99)00007-1
39343 - Monarda didyma: 10.1016/S0305-1978(99)00007-1
39344 - Monarda fistulosa: 10.1016/S0305-1978(99)00007-1
182387 - Monarda punctata: 10.1016/J.PHYTOCHEM.2010.08.009
182387 - Monarda punctata: 10.1016/S0305-1978(99)00007-1
1874238 - Mosla dianthera: 10.1248/CPB.47.1152
51089 - Myristica fragrans: 10.1021/JF051513Y
32072 - Neoblechnum brasiliense: 10.1055/S-2006-959906
39347 - Nepeta cataria: 10.1016/S0305-1978(99)00007-1
260608 - Nepeta grandiflora: 10.1016/S0305-1978(99)00007-1
1132403 - Nepeta italica: 10.1016/S0031-9422(98)00125-3
1533225 - Nepeta nuda: 10.1016/S0305-1978(99)00007-1
120697 - Oceaniopteris gibba: 10.1055/S-2006-959906
204141 - Ocimum americanum: 10.1016/J.FITOTE.2005.04.001
39350 - Ocimum basilicum:
204144 - Ocimum gratissimum: 10.1002/1099-1565(200007/08)11:4<257::AID-PCA521>3.0.CO;2-A
204149 - Ocimum tenuiflorum: 10.1016/S0944-7113(00)80015-X
196747 - Onopordum acaulon: 10.1016/0031-9422(92)83742-H
297478 - Onopordum illyricum: 10.1021/NP990098Z
497761 - Origanum dictamnus: 10.1021/JF904596M
452416 - Origanum onites: 10.1016/S0305-1978(99)00007-1
39352 - Origanum vulgare:
39352 - Origanum vulgare: 10.1021/JF061477I
204151 - Orthosiphon aristatus:
204151 - Orthosiphon aristatus: 10.1016/0031-9422(91)83190-V
48386 - Perilla frutescens:
48386 - Perilla Frutescens: -
48386 - Perilla frutescens: 10.1021/JF980557M
48386 - Perilla frutescens (L.) Britt.: -
151328 - Perilla frutescens var. frutescens: 10.1021/JF970520M
13216 - Piper nigrum: 10.1021/JF051513Y
185001 - Plantago lagopus: 10.1515/ZNC-2000-11-1205
33090 - Plants: -
41506 - Plectocephalus americanus: 10.1016/J.PHYTOCHEM.2006.08.012
41506 - Plectocephalus americanus: 10.1016/S0305-1978(01)00062-X
39358 - Prunella vulgaris:
21880 - Salvia:
39354 - Salvia abrotanoides:
39354 - Salvia abrotanoides: 10.1055/S-2006-951766
49207 - Salvia aethiopis: 10.1016/S0305-1978(99)00007-1
268888 - Salvia amplexicaulis: 10.1016/S0305-1978(99)00007-1
49208 - Salvia argentea: 10.1016/S0305-1978(99)00007-1
1520008 - Salvia aurea: 10.1016/S0305-1978(99)00007-1
392649 - Salvia austriaca: 10.1016/S0305-1978(99)00007-1
424416 - Salvia bowleyana: 10.1016/S0031-9422(01)00415-0
424416 - Salvia bowleyana: 10.1248/CPB.53.508
268891 - Salvia brachyantha: 10.1016/S0305-1978(99)00007-1
424418 - Salvia cavaleriei:
424418 - Salvia cavaleriei: 10.1248/CPB.53.508
424420 - Salvia chinensis:
424420 - Salvia chinensis: 10.1248/CPB.53.508
260612 - Salvia coccinea: 10.1016/S0305-1978(99)00007-1
342061 - Salvia deserta:
342061 - Salvia deserta: 10.1248/CPB.46.107
1520021 - Salvia deserti:
1520021 - Salvia deserti: 10.1248/CPB.46.107
342063 - Salvia flava:
342063 - Salvia flava: 10.1248/CPB.53.508
268906 - Salvia fruticosa:
49211 - Salvia glutinosa: 10.1016/S0305-1978(99)00007-1
1933728 - Salvia jurisicii: 10.1016/S0305-1978(99)00007-1
49214 - Salvia lavandulifolia: 10.1016/S0031-9422(01)00415-0
49214 - Salvia lavandulifolia: 10.1248/CPB.53.508
1685713 - Salvia limbata: 10.1080/14786411003766912
226208 - Salvia miltiorrhiza:
226208 - Salvia miltiorrhiza: 10.1016/S0031-9422(01)00415-0
226208 - Salvia miltiorrhiza Bge.: -
49215 - Salvia nemorosa: 10.1016/S0305-1978(99)00007-1
268918 - Salvia nilotica: 10.1016/S0305-1978(99)00007-1
268919 - Salvia nubicola: 10.1016/S0305-1978(99)00007-1
1933741 - Salvia nutans: 10.1016/S0305-1978(99)00007-1
38868 - Salvia officinalis:
268920 - Salvia palaestina:
268920 - Salvia palaestina: 10.1016/J.PHYTOCHEM.2007.11.002
49216 - Salvia pratensis: 10.1016/S0305-1978(99)00007-1
588964 - Salvia prionitis:
588964 - Salvia prionitis: 10.1016/0031-9422(95)00967-1
588964 - Salvia prionitis: 10.1248/CPB.53.508
342060 - Salvia przewalskii:
39367 - Salvia rosmarinus:
38869 - Salvia sclarea: 10.1016/S0305-1978(99)00007-1
1520043 - Salvia somalensis: 10.1016/S0305-1978(99)00007-1
2263220 - Salvia sonchifolia: 10.1016/S0031-9422(01)00415-0
2263220 - Salvia sonchifolia: 10.1248/CPB.53.508
180675 - Salvia splendens: 10.1016/S0305-1978(99)00007-1
1132405 - Salvia tomentosa: 10.1016/S0305-1978(99)00007-1
2886724 - Salvia transsylvanica: 10.1016/S0305-1978(99)00007-1
342065 - Salvia trijuga: 10.1076/PHBI.41.5.375.15938
268912 - Salvia verbenaca: 10.1016/S0305-1978(99)00007-1
49220 - Salvia verticillata: 10.1016/S0305-1978(99)00007-1
1298553 - Salvia virgata: 10.1016/S0305-1978(99)00007-1
268935 - Salvia viscosa: 10.1016/S0305-1978(99)00007-1
342062 - Salvia yunnanensis:
342062 - Salvia yunnanensis: 10.1248/CPB.45.1596
342062 - Salvia yunnanensis: 10.1248/CPB.53.508
13665 - Sanicula: 10.1021/NP9701790
71982 - Sanicula europaea: 10.1021/NP9701790
92927 - Sarcandra glabra: 10.1016/J.FITOTE.2009.12.009
49988 - Satureja montana: 10.1016/S0305-1978(99)00007-1
200489 - Saussurea involucrata: 10.1080/10286020.2010.499856
254913 - Saussurea laniceps: 10.1002/HLCA.200790096
254913 - Saussurea laniceps: 10.1016/S1875-5364(11)60016-2
2893703 - Saussurea macrota: 10.1002/CHIN.200516160
137893 - Saussurea medusa: 10.1016/S0031-9422(01)00429-0
137893 - Saussurea medusa: 10.1016/S0304-3835(00)00499-7
137893 - Saussurea medusa: 10.1248/CPB.53.1416
446849 - Saussurea salicifolia: 10.1016/J.FCT.2010.05.056
1053394 - Scrophularia scorodonia: 10.1016/0031-9422(95)00305-Q
278672 - Symphytum officinale: 10.1002/ARDP.19853181207
219868 - Syzygium aromaticum: 10.1021/JF051513Y
55496 - Thalassia hemprichii: 10.1007/S10600-014-1040-7
228974 - Thymus quinquecostatus: 10.1021/NP010636J
204219 - Thymus serpyllum: 10.1016/S0305-1978(99)00007-1
49992 - Thymus vulgaris:
49992 - Thymus vulgaris: 10.1021/NP010636J
50189 - Torreya nucifera: 10.1055/S-2001-15804
276781 - Trachelospermum asiaticum: 10.1016/0031-9422(72)80115-8
276781 - Trachelospermum asiaticum: 10.1248/CPB.34.4340
276781 - Trachelospermum asiaticum: 10.1248/YAKUSHI1947.93.4_539
429296 - Trachelospermum axillare: 10.1016/0031-9422(93)85183-R
947960 - Trachelospermum gracilipes: 10.1016/0031-9422(72)80115-8
69389 - Trachelospermum jasminoides: 10.1248/YAKUSHI1947.93.4_539
203766 - Trigonotis peduncularis: 10.1021/NP800071R
415523 - Triumfetta rhomboidea: 10.1002/JCCS.199500016
190534 - Vaccinium arctostaphylos: 10.1007/BF00564467
190534 - Vaccinium arctostaphylos: 10.1055/S-0030-1264382
751877 - Zataria multiflora: 10.1016/J.FITOTE.2004.01.017
4650 - Zingiber: 10.1021/JF051513Y
33090 - 迷迭香: -
569774 - 金线莲: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Mohsen Mardani, Katalin Badakné, Ildikó Szedljak, Csilla Sörös, Jamshid Farmani. Lipophilized rosmarinic acid: Impact of alkyl type and food matrix on antioxidant activity, and optimized enzymatic production. Food chemistry. 2024 Sep; 452(?):139518. doi: 10.1016/j.foodchem.2024.139518. [PMID: 38713983]
Łukasz Sęczyk, Elvyra Jariene, Danuta Sugier, Barbara Kołodziej. Effects of the dose of administration, co-antioxidants, food matrix, and digestion-related factors on the in vitro bioaccessibility of rosmarinic acid - A model study. Food chemistry. 2024 Aug; 449(?):139201. doi: 10.1016/j.foodchem.2024.139201. [PMID: 38599104]
Guanwen Xie, Xiuzai Zou, Zishan Liang, Ke Zhang, Duan Wu, Honglei Jin, Hongbin Wang, Qi Shen. GBF family member PfGBF3 and NAC family member PfNAC2 regulate rosmarinic acid biosynthesis under high light. Plant physiology. 2024 Jun; 195(2):1728-1744. doi: 10.1093/plphys/kiae036. [PMID: 38441888]
Guilian Zhang, Yuee Sun, Najeeb Ullah, Deepak Kasote, Longyi Zhu, Hui Liu, Ling Xu. Changes in secondary metabolites contents and stress responses in Salvia miltiorrhiza via ScWRKY35 overexpression: Insights from a wild relative Salvia castanea. Plant physiology and biochemistry : PPB. 2024 Jun; 211(?):108671. doi: 10.1016/j.plaphy.2024.108671. [PMID: 38703500]
Sara Motyka, Agnieszka Szopa, Sergio J Ochatt. Distinction of chia varieties in vivo and in vitro based on the flow cytometry and rosmarinic acid production. Applied microbiology and biotechnology. 2024 May; 108(1):337. doi: 10.1007/s00253-024-13171-w. [PMID: 38767664]
Mei Ling Ng, Amin Malik Shah Abdul Majid, Siew Mei Yee, V Natesan, Mohamed Khadeer Ahamed Basheer, Ashok Gnanasekaran, Fouad Saleih Resq Al-Suede, Christopher Parish, Meena Dalal, Long Chiau Ming, Mansoureh Nazari V, Shamsuddin Sultan Khan, Siti Balkees Stn Hameed Sultan, K Govind Babu, Aman Shah Abdul Majid, Mohamed Amir Shah Abdul Aziz. A phase II randomized, double-blind, placebo-controlled study of Nuvastatic (C50SEW505OESA), a standardized rosmarinic acid-rich polymolecular botanical extract formulation to reduce cancer-related fatigue in patients with solid tumors. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2024 May; 32(6):331. doi: 10.1007/s00520-024-08536-w. [PMID: 38710920]
Natticha Sumneang, Komsak Pintha, Sarawut Kongkarnka, Maitree Suttajit, Napapan Kangwan. Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice. Molecules (Basel, Switzerland). 2024 Apr; 29(9):. doi: 10.3390/molecules29091940. [PMID: 38731431]
Mona H Soliman, Suliman M S Alghanem, Ibtisam M Alsudays, Abdullah Alaklabi, Basmah M Alharbi, Hadba Al-Amrah, Ehab Azab, Ghalia S H Alnusairi. Co-application of titanium nanoparticles and melatonin effectively lowered chromium toxicity in lemon balm (Melissa officinalis L.) through modifying biochemical characteristics. Environmental science and pollution research international. 2024 Apr; 31(17):25258-25272. doi: 10.1007/s11356-024-32771-7. [PMID: 38468007]
Tian-Bao Wang, Ying He, Rui-Cheng Li, Yu-Xi Yu, Yu Liu, Zhong-Quan Qi. Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155448. doi: 10.1016/j.phymed.2024.155448. [PMID: 38394736]
Ke Zhang, Han Li, Jingjing Shi, Wenjing Liu, Yitao Wang, Pengfei Tu, Jun Li, Yuelin Song. Strategy strengthens structural identification through hyphenating full collision energy ramp-MS2 and full exciting energy ramp-MS3 spectra: An application for metabolites identification of rosmarinic acid. Analytica chimica acta. 2024 Apr; 1296(?):342346. doi: 10.1016/j.aca.2024.342346. [PMID: 38401935]
Jafar Fatahi Asl, Mehdi Goudarzi, Esrafil Mansouri, Hamed Shoghi. Rosmarinic Acid Protects the Testes of Rats against Cell Phone and Ultra-high Frequency Waves Induced Toxicity. Iranian journal of medical sciences. 2024 Apr; 49(4):237-246. doi: 10.30476/ijms.2023.97695.2952. [PMID: 38680223]
Hongtao Li, Meng Sun, Fuzhi Lei, Jinfeng Liu, Xixiang Chen, Yaqi Li, Ying Wang, Jiani Lu, Danmei Yu, Yueqiu Gao, Jianrong Xu, Hongzhuan Chen, Man Li, Zhigang Yi, Xiao He, Lili Chen. Methyl rosmarinate is an allosteric inhibitor of SARS-CoV-2 3 CL protease as a potential candidate against SARS-cov-2 infection. Antiviral research. 2024 Apr; 224(?):105841. doi: 10.1016/j.antiviral.2024.105841. [PMID: 38408645]
Maciej Jakobina, Jacek Łyczko, Antoni Szumny, Renata Galek. The influence of cultivation conditions on the formation of psychoactive salvinorin A, salvinorin B, rosmarinic acid and caffeic acid in Coleus scutellarioides. Scientific reports. 2024 03; 14(1):6693. doi: 10.1038/s41598-024-57399-y. [PMID: 38509159]
Zeinab Shariatmadari, Somayeh Zarezadeh, Hossein Riahi, Ali Akbar Ghotbi-Ravandi, Mehri Seyed Hashtroudi, Ensiyeh Shahroudi. Cyanobacterial elicitor enhances the biomass of Mentha piperita L. and improves the production of high-value rosmarinic acid under in vitro culture of apical meristem. BMC plant biology. 2024 Mar; 24(1):190. doi: 10.1186/s12870-024-04876-1. [PMID: 38486151]
Vasudeva Reddy Netala, Tianyu Hou, Siva Sankar Sana, Huizhen Li, Zhijun Zhang. Rosmarinic Acid-Rich Perilla frutescens Extract-Derived Silver Nanoparticles: A Green Synthesis Approach for Multifunctional Biomedical Applications including Antibacterial, Antioxidant, and Anticancer Activities. Molecules (Basel, Switzerland). 2024 Mar; 29(6):. doi: 10.3390/molecules29061250. [PMID: 38542889]
Paraskevi Yfanti, Polyxeni Lazaridou, Vasiliki Boti, Dimitra Douma, Marilena E Lekka. Enrichment of Olive Oils with Natural Bioactive Compounds from Aromatic and Medicinal Herbs: Phytochemical Analysis and Antioxidant Potential. Molecules (Basel, Switzerland). 2024 Mar; 29(5):. doi: 10.3390/molecules29051141. [PMID: 38474654]
Łukasz Sęczyk, Barbara Kołodziej. Bioaccessibility of Rosmarinic Acid and Basil (Ocimum basilicum L.) Co-Compounds in a Simulated Digestion Model-The Influence of the Endogenous Plant Matrix, Dose of Administration and Physicochemical and Biochemical Digestion Environment. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040901. [PMID: 38398652]
Jiuseng Zeng, Zhiqiang Xie, Li Chen, Xi Peng, Fei Luan, Jingwen Hu, Hongxiao Xie, Rong Liu, Nan Zeng. Rosmarinic acid alleviate CORT-induced depressive-like behavior by promoting neurogenesis and regulating BDNF/TrkB/PI3K signaling axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):115994. doi: 10.1016/j.biopha.2023.115994. [PMID: 38070249]
Xiaoyu Li, Yali Lin, Yong Qin, Guiqi Han, Hai Wang, Zhuyun Yan. Beneficial endophytic fungi improve the yield and quality of Salvia miltiorrhiza by performing different ecological functions. PeerJ. 2024; 12(?):e16959. doi: 10.7717/peerj.16959. [PMID: 38406278]
Teng Ma, Jia-Qi Chen, Tie Yao, Bing-Yang Zhang, Feng Qiu. New depside and rosmarinic acid derivatives from Perilla frutescens and their anti-inflammatory activity. Journal of Asian natural products research. 2024 Jan; 26(1):69-77. doi: 10.1080/10286020.2024.2308794. [PMID: 38305031]
Urmi Rahman Rinik, Ji Eon Kim, Eunok Lee, Oran Kwon, Byung Hwa Jung. Development of simultaneous quantitative analytical method for three active components of Korean mint (Agastache rugosa (Fisch. & C.A.Mey.) Kuntze) extract in human plasma using ultra-high-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2024 Jan; 1232(?):123957. doi: 10.1016/j.jchromb.2023.123957. [PMID: 38134516]
Qiong Ge, Zhewen Zhang, Zhiming Cao, Dan Wu, Changping Xu, Jianbiao Yao, Jian Gao, Yan Feng. Exploration of the in vitro Antiviral Effects and the Active Components of Changyanning Tablets Against Enterovirus 71. Drug design, development and therapy. 2024; 18(?):651-665. doi: 10.2147/dddt.s444625. [PMID: 38450095]
Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Pincha Devage Sameera Madushan Fernando, Jin Won Hyun. Rosmarinic Acid Protects Skin Keratinocytes from Particulate Matter 2.5-Induced Apoptosis. International journal of medical sciences. 2024; 21(4):681-689. doi: 10.7150/ijms.90814. [PMID: 38464827]
Ambika Goswami, Adinpunya Mitra. Light spectra manipulation stimulates growth, specialized metabolites and nutritional quality in Anethum graveolens. Journal of photochemistry and photobiology. B, Biology. 2023 Dec; 249(?):112812. doi: 10.1016/j.jphotobiol.2023.112812. [PMID: 37972447]
Wei Quan, Yuan Wang, Yu-Han Chen, Qing Shao, Yang-Ze Gong, Jie-Wen Hu, Wei-Hai Liu, Zi-Jun Wu, Jie Wang, Shan-Bo Ma, Xiao-Qiang Li. Screening of rosmarinic acid from Salvia miltiorrhizae acting on the novel target TRPC1 based on the 'homology modelling-virtual screening-molecular docking-affinity assay-activity evaluation' method. Pharmaceutical biology. 2023 Dec; 61(1):155-164. doi: 10.1080/13880209.2022.2160769. [PMID: 36604840]
Hajar Salehi, Leilei Zhang, Fatma Nur Alp-Turgut, Busra Arikan, Fevzi Elbasan, Ceyda Ozfidan-Konakci, Melike Balcı, Gökhan Zengin, Evren Yildiztugay, Luigi Lucini. The exogenous application of naringenin and rosmarinic acid modulates functional traits in Lepidium sativum. Journal of the science of food and agriculture. 2023 Nov; ?(?):. doi: 10.1002/jsfa.13160. [PMID: 37994181]
Mingzhi Zhong, Lei Zhang, Haomiao Yu, Jinqiu Liao, Yuanyuan Jiang, Songyue Chai, Ruiwu Yang, Long Wang, Xuexue Deng, Songlin Zhang, Qingmiao Li, Li Zhang. Identification and characterization of a novel tyrosine aminotransferase gene (SmTAT3-2) promotes the biosynthesis of phenolic acids in Salvia miltiorrhiza Bunge. International journal of biological macromolecules. 2023 Nov; 254(Pt 2):127858. doi: 10.1016/j.ijbiomac.2023.127858. [PMID: 37924917]
Salfarina Ezrina Mohmad Saberi, Lee Suan Chua. Potential of rosmarinic acid from Orthosiphon aristatus extract for inflammatory induced diseases and its mechanisms of action. Life sciences. 2023 Oct; 333(?):122170. doi: 10.1016/j.lfs.2023.122170. [PMID: 37827234]
Md Khabeer Azhar, Saleha Anwar, Gulam Mustafa Hasan, Anas Shamsi, Asimul Islam, Suhel Parvez, Md Imtaiyaz Hassan. Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases. Nutrients. 2023 Oct; 15(19):. doi: 10.3390/nu15194297. [PMID: 37836581]
Tingting Zhang, Huimin Gao, Yali Fan, Shuya Chen, Yingying Li, Ruixia Liu, Tianhe Li, Chenghong Yin. Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid. Life sciences. 2023 Oct; 330(?):121912. doi: 10.1016/j.lfs.2023.121912. [PMID: 37423380]
Huan Liu, Rui Deng, Cheng-Wei Zhu, Hong-Kuan Han, Gang-Fan Zong, Lang Ren, Peng Cheng, Zhong-Hong Wei, Yang Zhao, Su-Yun Yu, Yin Lu. Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis. Acta pharmacologica Sinica. 2023 Sep; ?(?):. doi: 10.1038/s41401-023-01158-8. [PMID: 37749237]
Rodrigo S Pizani, Juliane Viganó, Letícia S Contieri, Monique M Strieder, Renan K Kamikawashi, Wagner Vilegas, Leonardo M de Souza Mesquita, Maurício A Rostagno. New selective and sustainable ultrasound-assisted extraction procedure to recover carnosic and rosmarinic acids from Rosmarinus officinalis by sequential use of bio-based solvents. Food chemistry. 2023 Sep; 435(?):137540. doi: 10.1016/j.foodchem.2023.137540. [PMID: 37778266]
Yea-Eun Lee, Eunok Lee, Urmi Rahman Rinik, Ji Yeon Kim, Byung Hwa Jung, Oran Kwon. Bioavailability of Korean mint (Agastache rugosa) polyphenols in humans and a Caco-2 cell model: a preliminary study exploring the efficacy. Food & function. 2023 Sep; ?(?):. doi: 10.1039/d3fo02665e. [PMID: 37723877]
Ju Ye, Cheng Wang, Yu-Jie Ma, Zha-Xi Baima, Yuan-Yuan Tang, Xu-Guang He, Min Ma. [Multi-component content determination of Dracocephalum tanguticum by quantitative analysis of multi-components by single-marker]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Aug; 48(15):4253-4260. doi: 10.19540/j.cnki.cjcmm.20230411.202. [PMID: 37802794]
Chiara Musillo, Letizia Giona, Michael Ristow, Kim Zarse, Karsten Siems, Alessia Di Francesco, Barbara Collacchi, Carla Raggi, Francesca Cirulli, Alessandra Berry. Rosmarinic Acid Improves Cognitive Abilities and Glucose Metabolism in Aged C57Bl/6N Mice While Disrupting Lipid Profile in Young Adults in a Sex-Dependent Fashion. Nutrients. 2023 Jul; 15(15):. doi: 10.3390/nu15153366. [PMID: 37571303]
Shah Faisal, Muhammad Hamza Tariq, Riaz Ullah, Sania Zafar, Muhammad Rizwan, Nadia Bibi, Aishma Khattak, Noora Amir, Abdullah. Exploring the antibacterial, antidiabetic, and anticancer potential of Mentha arvensis extract through in-silico and in-vitro analysis. BMC complementary medicine and therapies. 2023 Jul; 23(1):267. doi: 10.1186/s12906-023-04072-y. [PMID: 37496047]
Chunyan Zhu, Yunchang Fan, Hongwei Wu. The Selective Separation of Carnosic Acid and Rosmarinic Acid by Solid-Phase Extraction and Liquid-Liquid Extraction: A Comparative Study. Molecules (Basel, Switzerland). 2023 Jul; 28(14):. doi: 10.3390/molecules28145493. [PMID: 37513364]
Jennifer M Marsh, Shane Whitaker, Lijuan Li, Rui Fang, Monique S J Simmonds, Nikolaos Vagkidis, Victor Chechik. The key phytochemistry of Rosemary (Salvia rosmarinus) contributing to Hair Protection against UV. International journal of cosmetic science. 2023 Jul; ?(?):. doi: 10.1111/ics.12883. [PMID: 37461190]
Emine Yurteri. Volatile Oil Yield and Composition, Total Phenolic Content, Antioxidant Activity and Secondary Metabolite Content of Collected Thymus praecox Species in Rize. Chemistry & biodiversity. 2023 Jul; 20(7):e202300180. doi: 10.1002/cbdv.202300180. [PMID: 37200225]
Chunliu Wang, Jie Zhou, Shixiang Wang, Yang Liu, Kaihua Long, Tingting Sun, Wenbing Zhi, Yang Yang, Hong Zhang, Ye Zhao, Xiaopu Zheng, Xiaohui Zheng, Ye Li, Pu Jia. Guanxining injection alleviates fibrosis in heart failure mice and regulates SLC7A11/GPX4 axis. Journal of ethnopharmacology. 2023 Jun; 310(?):116367. doi: 10.1016/j.jep.2023.116367. [PMID: 36914037]
Katarzyna Sykłowska-Baranek, Małgorzata Gaweł, Łukasz Kuźma, Beata Wileńska, Mateusz Kawka, Małgorzata Jeziorek, Konstantia Graikou, Ioanna Chinou, Ewa Szyszko, Piotr Stępień, Patryk Zakrzewski, Agnieszka Pietrosiuk. Rindera graeca (A. DC.) Boiss. & Heldr. (Boraginaceae) In Vitro Cultures Targeting Lithospermic Acid B and Rosmarinic Acid Production. Molecules (Basel, Switzerland). 2023 Jun; 28(12):. doi: 10.3390/molecules28124880. [PMID: 37375435]
Marta Krzemińska, Katarzyna Hnatuszko-Konka, Izabela Weremczuk-Jeżyna, Aleksandra Owczarek-Januszkiewicz, Wiktoria Ejsmont, Monika A Olszewska, Izabela Grzegorczyk-Karolak. Effect of Light Conditions on Polyphenol Production in Transformed Shoot Culture of Salvia bulleyana Diels. Molecules (Basel, Switzerland). 2023 Jun; 28(12):. doi: 10.3390/molecules28124603. [PMID: 37375158]
Shumaila Ijaz, Javed Iqbal, Banzeer Ahsan Abbasi, Zakir Ullah, Tabassum Yaseen, Sobia Kanwal, Tariq Mahmood, Sandugash Sydykbayeva, Alibek Ydyrys, Zainab M Almarhoon, Javad Sharifi-Rad, Christophe Hano, Daniela Calina, William C Cho. Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 162(?):114687. doi: 10.1016/j.biopha.2023.114687. [PMID: 37062215]
Divya Gupta, Raghu Rai Sharma, Haroon Rashid, Aalim Maqsood Bhat, Malik Ahmad Tanveer, Sheikh Tasduq Abdullah. Rosmarinic acid alleviates ultraviolet-mediated skin aging via attenuation of mitochondrial and ER stress responses. Experimental dermatology. 2023 06; 32(6):799-807. doi: 10.1111/exd.14773. [PMID: 36811401]
Ourdia-Nouara Kernou, Zahra Azzouz, Khodir Madani, Patricia Rijo. Application of Rosmarinic Acid with Its Derivatives in the Treatment of Microbial Pathogens. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28104243. [PMID: 37241981]
Tuo Qin, Xiaojuan Rong, Xiaohui Zhang, Lingfei Kong, Yutong Kang, Xuanlin Liu, Mengying Hu, Handong Liang, Cai Tie. Lipid Mediators Metabolic Chaos of Asthmatic Mice Reversed by Rosmarinic Acid. Molecules (Basel, Switzerland). 2023 Apr; 28(9):. doi: 10.3390/molecules28093827. [PMID: 37175237]
Guofeng Zhong, Mengyu Qiu, Junbo Zhang, Fuchen Jiang, Xuan Yue, Chi Huang, Shiyi Zhao, Rui Zeng, Chen Zhang, Yan Qu. Fabrication and characterization of PVA@PLA electrospinning nanofibers embedded with Bletilla striata polysaccharide and Rosmarinic acid to promote wound healing. International journal of biological macromolecules. 2023 Apr; 234(?):123693. doi: 10.1016/j.ijbiomac.2023.123693. [PMID: 36806778]
Annapoorani Angusamy, Vigneshkumar Balasubramanian, Balaji Arunmurugan, Kannapan Arunachalam, Sybiya Vasantha Packiavathy Issac Abraham, Sivaranjani Murugesan, Balamurugan Krishnasamy, Janarthanan Sundaram, Veera Ravi Arumugam. Anti-infective potential of plant-derived quorum sensing inhibitors against multi-drug resistant human and aquatic bacterial pathogens. World journal of microbiology & biotechnology. 2023 Apr; 39(6):147. doi: 10.1007/s11274-023-03578-4. [PMID: 37022521]
Farzad Kianersi, Davood Amin Azarm, Farzaneh Fatemi, Bita Jamshidi, Alireza Pour-Aboughadareh, Tibor Janda. The Influence of Methyl Jasmonate on Expression Patterns of Rosmarinic Acid Biosynthesis Genes, and Phenolic Compounds in Different Species of Salvia subg. Perovskia Kar L. Genes. 2023 04; 14(4):. doi: 10.3390/genes14040871. [PMID: 37107629]
Ester Gonçalves de Jesus, Fernanda Fernandes de Souza, João Victor Andrade, Márcio Luís Andrade E Silva, Wilson R Cunha, Rafael Corrêa Ramos, Othon Souto Campos, Jorge Alexandre Nogueira Santos, Mario F C Santos. In silico and in vitro elastase inhibition assessment assays of rosmarinic acid natural product from Rosmarinus officinalis Linn. Natural product research. 2023 Apr; ?(?):1-6. doi: 10.1080/14786419.2023.2196077. [PMID: 37004998]
Ana Paula Martin, María Florencia Martínez, María Amalia Chiesa, Lucila Garcia, Nadia Gerhardt, Facundo Uviedo, Pablo S Torres, María Rosa Marano. Priming crop plants with rosemary (Salvia rosmarinus Spenn, syn Rosmarinus officinalis L.) extract triggers protective defense response against pathogens. Plant physiology and biochemistry : PPB. 2023 Apr; 197(?):107644. doi: 10.1016/j.plaphy.2023.107644. [PMID: 36996636]
Izabela Fecka, Katarzyna Bednarska, Adam Kowalczyk. In Vitro Antiglycation and Methylglyoxal Trapping Effect of Peppermint Leaf (Mentha × piperita L.) and Its Polyphenols. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062865. [PMID: 36985839]
Sarah Martins Presti-Silva, Alice Laschuk Herlinger, Cristina Martins-Silva, Rita Gomes Wanderley Pires. Biochemical and behavioral effects of rosmarinic acid treatment in an animal model of Parkinson's disease induced by MPTP. Behavioural brain research. 2023 Feb; 440(?):114257. doi: 10.1016/j.bbr.2022.114257. [PMID: 36526017]
XuHan Chen, Xu Xu, Jia Lv, JinQin Huang, LingLing Lyu, LiPing Liu. Potential Mechanisms of Perillae folium Against COVID-19: A Network Pharmacology Approach. Journal of medicinal food. 2023 Feb; ?(?):. doi: 10.1089/jmf.2022.k.0029. [PMID: 36787478]
Xiaopeng Hu, Sanqi An, Jiemei Chu, Bingyu Liang, Yanyan Liao, Junjun Jiang, Yao Lin, Li Ye, Hao Liang. Potential Inhibitors of Monkeypox Virus Revealed by Molecular Modeling Approach to Viral DNA Topoisomerase I. Molecules (Basel, Switzerland). 2023 Feb; 28(3):. doi: 10.3390/molecules28031444. [PMID: 36771105]
Ke-Mei Lai, Sheng-Yi Chen, Guan-Yu Wang, Fereidoon Shahidi, Gow-Chin Yen. Protective effect of rosmarinic acid-rich extract from Trichodesma khasianum Clarke against microbiota dysbiosis in high-fat diet-fed obese mice. Food research international (Ottawa, Ont.). 2023 02; 164(?):112344. doi: 10.1016/j.foodres.2022.112344. [PMID: 36737936]
Heba A Gad, Rania A H Ishak, Rola M Labib, Amany O Kamel. Ethyl lauroyl arginate-based hydrophobic ion pair complex in lipid nanocapsules: A novel oral delivery approach of rosmarinic acid for enhanced permeability and bioavailability. International journal of pharmaceutics. 2023 Jan; 630(?):122388. doi: 10.1016/j.ijpharm.2022.122388. [PMID: 36375682]
Ling-Ling Zheng, Mei-Lan Chen, Li-Ping Kang, Ying-Li Wang, Xiu-Teng Zhou. [Effect of Rhizophagus intraradices on growth of Salvia miltiorrhiza]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jan; 48(2):349-355. doi: 10.19540/j.cnki.cjcmm.20221017.101. [PMID: 36725224]
Ali Moghadam, Eisa Foroozan, Ahmad Tahmasebi, Mohammad Sadegh Taghizadeh, Mohammad Bolhassani, Morteza Jafari. System network analysis of Rosmarinus officinalis transcriptome and metabolome-Key genes in biosynthesis of secondary metabolites. PloS one. 2023; 18(3):e0282316. doi: 10.1371/journal.pone.0282316. [PMID: 36862714]
Moeko Noguchi-Shinohara, Tsuyoshi Hamaguchi, Kenji Sakai, Junji Komatsu, Kazuo Iwasa, Mai Horimoto, Hiroyuki Nakamura, Masahito Yamada, Kenjiro Ono. Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial. Journal of Alzheimer's disease : JAD. 2023; 91(2):805-814. doi: 10.3233/jad-220953. [PMID: 36502333]
Ting-Ting Chai, Yang-Na Huang, Shao-Tian Ren, Dan-Li Jin, Jing-Jing Fu, Jun-Yan Guo, Yue-Wen Chen. Inhibitory effects of ultrasonic and rosmarinic acid on lipid oxidation and lipoxygenase in large yellow croaker during cold storage. Ultrasonics sonochemistry. 2023 Jan; 92(?):106229. doi: 10.1016/j.ultsonch.2022.106229. [PMID: 36459902]
Xin-Yu Lin, Jing Zhou, Cai-Feng Hao, He Zhu, Shan-Shan Zhou, Jin-Di Xu, Qian Mao, Song-Lin Li, Ming Kong. Quality consistency evaluation of commercial Prunellae Spica by integrating determination of secondary metabolites and saccharides. Phytochemical analysis : PCA. 2022 Dec; ?(?):. doi: 10.1002/pca.3197. [PMID: 36494085]
Ahmed Aj Jabbar, Fuad O Abdullah, Abdullah Othman Hassan, Yaseen Galali, Rawaz Rizgar Hassan, Essa Q Rashid, Musher Ismael Salih, Kareem Fattah Aziz. Ethnobotanical, Phytochemistry, and Pharmacological Activity of Onosma (Boraginaceae): An Updated Review. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248687. [PMID: 36557820]
Jia Sun, Jing-Ya Zhang, Rong Li, Lin Zheng, Chun-Hua Liu, Ding-Yan Lu, Ting Liu. [Effects and correlation of ligustrazine hydrochloride-Salviae Miltiorrhizae Radix et Rhizoma compatibility on pharmacokinetics and CYP450 enzyme]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Dec; 47(23):6348-6354. doi: 10.19540/j.cnki.cjcmm.20220411.202. [PMID: 36604879]
Ji-Xian Song, Ya-Shuo Zhao, Ya-Qin Zhen, Xin-Yue Yang, Qi Chen, Ji-Ren An, En-Sheng Ji. Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia. Pharmaceutical biology. 2022 Dec; 60(1):609-620. doi: 10.1080/13880209.2022.2043392. [PMID: 35286247]
Saduddin Talukder, Khondoker Shahin Ahmed, Hemayet Hossain, Tarek Hasan, Israt Jahan Liya, Muhammed Amanat, Nurun Nahar, Md Sadikur Rahman Shuvo, A F M Shahid Ud Daula. Fimbristylis aestivalis Vahl: a potential source of cyclooxygenase-2 (COX-2) inhibitors. Inflammopharmacology. 2022 Dec; 30(6):2301-2315. doi: 10.1007/s10787-022-01057-0. [PMID: 36056995]
Ling Xu, Mengting Cao, Qichao Wang, Jiahao Xu, Chenglin Liu, Najeeb Ullah, Juanjuan Li, Zhuoni Hou, Zongsuo Liang, Weijun Zhou, Ake Liu. Insights into the plateau adaptation of Salvia castanea by comparative genomic and WGCNA analyses. Journal of advanced research. 2022 12; 42(?):221-235. doi: 10.1016/j.jare.2022.02.004. [PMID: 36089521]
Saeed Azizi, Neda Mohamadi, Fariba Sharififar, Gholamreza Dehghannoudeh, Farzaneh Jahanbakhsh, Fatemeh Dabaghzadeh. Rosemary as an adjunctive treatment in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial. Complementary therapies in clinical practice. 2022 Nov; 49(?):101685. doi: 10.1016/j.ctcp.2022.101685. [PMID: 36343423]
Tayebeh Ahmadi, Leila Shabani, Mohammad R Sabzalian. Light emitting diodes improved the metabolism of rosmarinic acid and amino acids at the transcriptional level in two genotypes of Melissa officinalis L. Functional plant biology : FPB. 2022 11; 49(12):1055-1069. doi: 10.1071/fp21364. [PMID: 36043232]
Zhimin Zhang, Qian Su, Bohou Xia, Yamei Li, Xinyi Qin, Hongshan Luo, Yan Lin, Jingchen Xie, Ping Wu, Limei Lin, Duanfang Liao. Integrative transcriptomic, proteomic and metabolomic analysis reveals the dynamic regulation of secondary metabolism upon development of Prunella vulgaris L. Fitoterapia. 2022 Nov; 163(?):105334. doi: 10.1016/j.fitote.2022.105334. [PMID: 36272703]
Ju Jin, Darren C Holland, Anthony R Carroll, Matthew Zunk. Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson's Curse (Echium plantagineum). Journal of natural products. 2022 10; 85(10):2474-2479. doi: 10.1021/acs.jnatprod.2c00151. [PMID: 36126331]
Vittoria Borgonetti, Giovanna Pressi, Oriana Bertaiola, Chiara Guarnerio, Manuela Mandrone, Ilaria Chiocchio, Nicoletta Galeotti. Attenuation of neuroinflammation in microglia cells by extracts with high content of rosmarinic acid from in vitro cultured Melissa officinalis L. cells. Journal of pharmaceutical and biomedical analysis. 2022 Oct; 220(?):114969. doi: 10.1016/j.jpba.2022.114969. [PMID: 35961210]
Ah-Kyung Jang, Md Mamunur Rashid, Gakyung Lee, Doo-Young Kim, Hyung Won Ryu, Sei-Ryang Oh, Jinyoung Park, Hyunbeom Lee, Jongki Hong, Byung Hwa Jung. Metabolites identification for major active components of Agastache rugosa in rat by UPLC-Orbitap-MS: Comparison of the difference between metabolism as a single component and as a component in a multi-component extract. Journal of pharmaceutical and biomedical analysis. 2022 Oct; 220(?):114976. doi: 10.1016/j.jpba.2022.114976. [PMID: 35939877]
Ali Naseri, Abolfazl Alirezalu, Parviz Noruzi, Kazem Alirezalu. The effect of different ammonium to nitrate ratios on antioxidant activity, morpho-physiological and phytochemical traits of Moldavian balm (Dracocephalum moldavica). Scientific reports. 2022 10; 12(1):16841. doi: 10.1038/s41598-022-21338-6. [PMID: 36207586]
Jiachao Zhao, Liwei Xu, Di Jin, Yu Xin, Lin Tian, Tan Wang, Daqing Zhao, Zeyu Wang, Jing Wang. Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer. Biomolecules. 2022 10; 12(10):. doi: 10.3390/biom12101410. [PMID: 36291619]
Himanshu Verma, Naveen Shivavedi, Gullanki N V C Tej, Mukesh Kumar, Prasanta K Nayak. Prophylactic administration of rosmarinic acid ameliorates depression-associated cardiac abnormalities in Wistar rats: Evidence of serotonergic, oxidative, and inflammatory pathways. Journal of biochemical and molecular toxicology. 2022 Oct; 36(10):e23160. doi: 10.1002/jbt.23160. [PMID: 35838106]
Ashutosh Joshi, Gajendra Singh Jeena, Shikha, Ravi Shankar Kumar, Alok Pandey, Rakesh Kumar Shukla. Ocimum sanctum, OscWRKY1, regulates phenylpropanoid pathway genes and promotes resistance to pathogen infection in Arabidopsis. Plant molecular biology. 2022 Oct; 110(3):235-251. doi: 10.1007/s11103-022-01297-2. [PMID: 35780285]
Nilay Kahya, Sacide Melek Kestir, Seray Öztürk, Alara Yolaç, Emrah Torlak, Zeynep Kalaycıoğlu, Gülşen Akın-Evingür, F Bedia Erim. Antioxidant and antimicrobial chitosan films enriched with aqueous sage and rosemary extracts as food coating materials: Characterization of the films and detection of rosmarinic acid release. International journal of biological macromolecules. 2022 Sep; 217(?):470-480. doi: 10.1016/j.ijbiomac.2022.07.073. [PMID: 35835308]
Esra Küpeli Akkol, Gülin Renda, Mert İlhan, Nurdan Yazıcı Bektaş. Wound healing acceleration and anti-inflammatory potential of Prunella vulgaris L.: From conventional use to preclinical scientific verification. Journal of ethnopharmacology. 2022 Sep; 295(?):115411. doi: 10.1016/j.jep.2022.115411. [PMID: 35636653]
Yi Yu, Ye Li, Keming Qi, Wei Xu, Yicong Wei. Rosmarinic acid relieves LPS-induced sickness and depressive-like behaviors in mice by activating the BDNF/Nrf2 signaling and autophagy pathway. Behavioural brain research. 2022 09; 433(?):114006. doi: 10.1016/j.bbr.2022.114006. [PMID: 35843463]
Márcio L A E Silva, Rodrigo Lucarini, Fransergio F Dos Santos, Carlos H G Martins, Patricia M Pauletti, Ana H Januario, Mario Ferreira Conceição Santos, Wilson R Cunha. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Natural product research. 2022 Sep; 36(17):4525-4531. doi: 10.1080/14786419.2021.1990282. [PMID: 34647501]
Muhammad Mughees, Muhammad Asad Farooq, Ihsan Ul Haq, Iftikhar Zeb, Muhammad Ali, Zahoor Hussain, Irum Shahzadi, Mohammad Maroof Shah. Quantification of rosmarinic acid from different plant species of lower Himalayan region and expression analysis of underlying L-Phenylalanine pathway. Physiologia plantarum. 2022 Sep; 174(5):e13758. doi: 10.1111/ppl.13758. [PMID: 36281843]
Miroslava Stanković, Jovana D Ickovski, Radomir B Ljupković, Gordana S Stojanović. The effects of Artemisia methanol extracts and ferulic acid, rutin, rosmarinic acid, and quercetin on micronucleus distribution on human lymphocytes. Natural product research. 2022 Sep; 36(17):4536-4539. doi: 10.1080/14786419.2021.1990918. [PMID: 34658273]
Jian Fu, Ziyao He, Huixiao Fu, Yufen Xia, Inès N'Go, Huayong Lou, Jinglan Wu, Weidong Pan, Stéphane P Vincent. Synthesis and evaluation of inhibitors of Mycobacterium tuberculosis UGM using bioisosteric replacement. Bioorganic & medicinal chemistry. 2022 09; 69(?):116896. doi: 10.1016/j.bmc.2022.116896. [PMID: 35777270]
Yang Yao, Rong Li, Dan Liu, Lihui Long, Na He. Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway. Ecotoxicology and environmental safety. 2022 Aug; 241(?):113773. doi: 10.1016/j.ecoenv.2022.113773. [PMID: 35753269]
Natalia Vilmosh, Delyan Delev, Ilia Kostadinov, Hristina Zlatanova, Maria Kotetarova, Ilin Kandilarov, Ivanka Kostadinova. Anxiolytic Effect of Satureja montana Dry Extract and its Active Compounds Rosmarinic Acid and Carvacrol in Acute Stress Experimental Model. Journal of integrative neuroscience. 2022 Jul; 21(5):124. doi: 10.31083/j.jin2105124. [PMID: 36137956]
Minjie Jiang, Shujie Fu, Kebei Chen, Qing Li, Weizhe Jiang. Pharmacokinetic Analysis of Rosmarinic Acid and its Analog in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry. Journal of chromatographic science. 2022 Jul; 60(6):511-517. doi: 10.1093/chromsci/bmab074. [PMID: 34173646]
Pariya Pirooz, Rayhaneh Amooaghaie, Alimohammad Ahadi, Fariba Sharififar, Masoud Torkzadeh-Mahani. Silicon and nitric oxide synergistically modulate the production of essential oil and rosmarinic acid in Salvia officinalis under Cu stress. Protoplasma. 2022 Jul; 259(4):905-916. doi: 10.1007/s00709-021-01708-z. [PMID: 34596758]
Divya Gupta, Sajida Archoo, Shahid Hussain Naikoo, Sheikh Tasduq Abdullah. Rosmarinic Acid: A Naturally Occurring Plant Based Agent Prevents Impaired Mitochondrial Dynamics and Apoptosis in Ultraviolet-B-Irradiated Human Skin Cells. Photochemistry and photobiology. 2022 07; 98(4):925-934. doi: 10.1111/php.13533. [PMID: 34608633]
Nanthakarn Woottisin, Sophida Sukprasert, Thitianan Kulsirirat, Thipaporn Tharavanij, Korbtham Sathirakul. Evaluation of the Intestinal Permeability of Rosmarinic Acid from Thunbergia laurifolia Leaf Water Extract in a Caco-2 Cell Model. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123884. [PMID: 35745006]
Tahereh Komeili-Movahhed, Mahdi Bassirian, Zahra Changizi, Azam Moslehi. SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH). Journal of receptor and signal transduction research. 2022 Jun; 42(3):241-250. doi: 10.1080/10799893.2021.1905665. [PMID: 33787460]
Busra Arikan, Ceyda Ozfidan-Konakci, Fatma Nur Alp, Gökhan Zengin, Evren Yildiztugay. Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress. Phytochemistry. 2022 Jun; 198(?):113157. doi: 10.1016/j.phytochem.2022.113157. [PMID: 35271935]
Ritesh Panchal, Saikat Ghosh, Rajeev Mehla, Jayachandran Ramalingam, Sunil Gairola, Sandeepan Mukherjee, Abhay Chowdhary. Antiviral Activity of Rosmarinic Acid Against Four Serotypes of Dengue Virus. Current microbiology. 2022 May; 79(7):203. doi: 10.1007/s00284-022-02889-3. [PMID: 35612625]
Huaquan Guan, Wenbin Luo, Beihua Bao, Yudan Cao, Fangfang Cheng, Sheng Yu, Qiaoling Fan, Li Zhang, Qinan Wu, Mingqiu Shan. A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight. Molecules (Basel, Switzerland). 2022 May; 27(10):. doi: 10.3390/molecules27103292. [PMID: 35630768]
Yi-Hsien Hsieh, Jen-Pi Tsai, Yi-Hsuan Ting, Tung-Wei Hung, Wen-Wan Chao. Rosmarinic acid ameliorates renal interstitial fibrosis by inhibiting the phosphorylated-AKT mediated epithelial-mesenchymal transition in vitro and in vivo. Food & function. 2022 Apr; 13(8):4641-4652. doi: 10.1039/d2fo00204c. [PMID: 35373225]
Matteo Perra, Laura Fancello, Ines Castangia, Mohamad Allaw, Elvira Escribano-Ferrer, José Esteban Peris, Iris Usach, Maria Letizia Manca, Ivanka K Koycheva, Milen I Georgiev, Maria Manconi. Formulation and Testing of Antioxidant and Protective Effect of Hyalurosomes Loading Extract Rich in Rosmarinic Acid Biotechnologically Produced from Lavandula angustifolia Miller. Molecules (Basel, Switzerland). 2022 Apr; 27(8):. doi: 10.3390/molecules27082423. [PMID: 35458621]
Diana Pontes da Silva, Sarah de Sousa Ferreira, Manoela Torres-Rêgo, Allanny Alves Furtado, Fabiana de Oliveira Yamashita, Eduardo Augusto da Silva Diniz, Davi Serradella Vieira, Marcela Abbott Galvão Ururahy, Arnóbio Antônio da Silva-Júnior, Karla Patrícia de Oliveira Luna, Matheus de Freitas Fernandes-Pedrosa. Antiophidic potential of chlorogenic acid and rosmarinic acid against Bothrops leucurus snake venom. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Apr; 148(?):112766. doi: 10.1016/j.biopha.2022.112766. [PMID: 35247716]
Seung-Won Jung, Gi Hyun Park, Eunjung Kim, Kang Min Yoo, Hea Won Kim, Jin Soo Lee, Min Youl Chang, Kyong-Oh Shin, Kyungho Park, Eung Ho Choi. Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function. International journal of molecular sciences. 2022 Mar; 23(7):. doi: 10.3390/ijms23073910. [PMID: 35409270]
Farzad Kianersi, Davood Amin Azarm, Alireza Pour-Aboughadareh, Peter Poczai. Change in Secondary Metabolites and Expression Pattern of Key Rosmarinic Acid Related Genes in Iranian Lemon Balm (Melissa officinalis L.) Ecotypes Using Methyl Jasmonate Treatments. Molecules (Basel, Switzerland). 2022 Mar; 27(5):. doi: 10.3390/molecules27051715. [PMID: 35268816]