Berberine (BioDeep_00000000087)

 

Secondary id: BioDeep_00000397978, BioDeep_00001867462

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


16,17-dimethoxy-5,7-dioxa-13lambda5-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2,4(8),9,13,15,17,19-octaen-13-ylium

化学式: [C20H18NO4]+ (336.1236)
中文名称: 小檗碱, 黄连素
谱图信息: 最多检出来源 Homo sapiens(blood) 18.15%

Reviewed

Last reviewed on 2024-09-04.

Cite this Page

Berberine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/berberine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000087). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: COc(c5)c(OC)c(c4)c(c5)cc([n+1]34)c(c1)c(CC3)cc(O2)c(OC2)1
InChI: InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1

描述信息

Berberine is an organic heteropentacyclic compound, an alkaloid antibiotic, a botanical anti-fungal agent and a berberine alkaloid. It has a role as an antilipemic drug, a hypoglycemic agent, an antioxidant, a potassium channel blocker, an antineoplastic agent, an EC 1.1.1.21 (aldehyde reductase) inhibitor, an EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor, an EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor, an EC 1.21.3.3 (reticuline oxidase) inhibitor, an EC 2.1.1.116 [3-hydroxy-N-methyl-(S)-coclaurine 4-O-methyltransferase] inhibitor, an EC 3.1.1.4 (phospholipase A2) inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor, an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 2.7.11.10 (IkappaB kinase) inhibitor, an EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor, a geroprotector and a metabolite.
An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
Berberine is a quaternary ammonia compound found in many botanical products, including goldenseal, barberry and Oregon grape, which is used for its purported antioxidant and antimicrobial properties for a host of conditions, including obesity, diabetes, hyperlipidemia, heart failure, H. pylori infection and colonic adenoma prevention. Berberine has not been linked to serum aminotransferase elevations during therapy nor to instances of clinically apparent liver injury.
Berberine is a natural product found in Berberis poiretii, Thalictrum delavayi, and other organisms with data available.
Berberine is a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the expression of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1), hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription 3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism.
An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
See also: Goldenseal (part of); Berberis aristata stem (part of).
Berberine is a quaternary ammonium salt that belongs to the protoberberine group of benzylisoquinoline alkaloids. Chemically, berberine is classified as an isoquinoline alkaloid. More specifically, berberine is a plant alkaloid derived from tyrosine through a complex 8 step biosynthetic process. Berberine is found in plants such as Berberis vulgaris (barberry), Berberis aristata (tree turmeric), Mahonia aquifolium (Oregon grape) and Hydrastis canadensis (goldenseal). Two other known berberine-containing plants are Phellodendron chinense and Phellodendron amurense. Berberine is usually found in the roots, rhizomes, stems, and bark of Berberis plants. Due to berberines intense yellow color, plants that contain berberine were traditionally used to dye wool, leather, and wood. Under ultraviolet light, berberine shows a strong yellow fluorescence, making it useful in histology for staining heparin in mast cells. Berberine is a bioactive plant compound that has been frequently used in traditional medicine. Among the known physiological effects or bioactivities are: 1) Antimicrobial action against bacteria, fungi, protozoa, viruses, helminthes, and Chlamydia; 2) Antagonism against the effects of cholera and E coli heat-stable enterotoxin; 3) Inhibition of intestinal ion secretion and of smooth muscle contraction; 4) Reduction of inflammation and 5) Stimulation of bile secretion and bilirubin discharge (PMID:32335802). Berberine can inhibit bacterial growth in the gut, including Helicobacter pylori, protect the intestinal epithelial barrier from injury, and ameliorate liver injury. Currently, berberine is sold as an Over-the-Counter (OTC) drug for treating gastrointestinal infections in China (PMID:18442638). Berberine also inhibits the proliferation of various types of cancer cells and impedes invasion and metastasis (PMID:32335802). Recent evidence has also confirmed that berberine improves the efficacy and safety of both chemo and radiotherapies for cancer treatment (PMID:32335802). Berberine has also been shown to regulate glucose and lipid metabolism in vitro and in vivo (PMID:18442638). In fact, berberine is the main active component of an ancient Chinese herb Coptis chinensis French, which has been used to treat diabetes for thousands of years. As an anti-diabetic, berberine increases glucose uptake by muscle fibers independent of insulin levels. It triggers AMPK activation and increases glycolysis, leading to decreased insulin resistance and decreased oxygen respiration. The same mechanism leads to a reduction in gluconeogenesis in the liver. AMPK activation by berberine also leads to an antiatherosclerotic effect in mice. Berberines AMPK activation may also underlie berberines anti-obesity effects and favorable influence on weight loss (PMID:18442638). While its use as a medication is widely touted, it is important to remember that berberine inhibits CYP2D6 and CYP3A4 enzymes, both of which are involved in the metabolism of many endogenous substances and xenobiotics, including a number of prescription drugs.
An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal. [HMDB]
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
[Raw Data] CBA98_Berberine_pos_50eV.txt
[Raw Data] CBA98_Berberine_pos_10eV.txt
[Raw Data] CBA98_Berberine_pos_20eV.txt
[Raw Data] CBA98_Berberine_pos_40eV.txt
[Raw Data] CBA98_Berberine_pos_30eV.txt

Berberine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=2086-83-1 (retrieved 2024-09-04) (CAS RN: 2086-83-1). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

81 个代谢物同义名

16,17-dimethoxy-5,7-dioxa-13lambda5-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2,4(8),9,13,15,17,19-octaen-13-ylium; 16,17-dimethoxy-5,7-dioxa-13$l^{5}-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-13-ylium; InChI=1/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+; 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene; 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ylium; chloride; 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ylium chloride; 9,10-Dimethoxy-5,6-dihydro-7lambda~5~-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo-[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium; 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium; Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, chloride; Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy- (9CI); 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ylium; 3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrido[2,1-a]isoquinolin-5-ylium; 9,10-DIMETHOXY-5,6-DIHYDRO(1,3)DIOXOLO(4,5-G)ISOQUINO(3,2-A)ISOQUINOLIN-7-IUM; 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-; Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-; 5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium; Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-; 5,6-DIHYDRO-9,10-DIMETHOXYBENZO(G)-1,3-BENZODIOXOLO(5,6-A)QUINOLIZINIUM; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenebis(oxy))berbinium; 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-[methylenebis(oxy)]berbinium; 5,6-DIHYDRO-9,10-DIMETHOXY-1,3-BENZODIOXOLO(5,6-A)BENZO(G)QUINOLIZINIUM; BERBINIUM, 7,8,13,13a-TETRAHYDRO-9,10-DIMETHOXY-2,3-(METHYLENEDIOXY)-; 9,10-dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetradehydroberbinium; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium; Benzylpenicillin benzathine, Antibiotic for Culture Media Use Only; 9,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium; BERBERINE (CONSTITUENT OF GOLDENSEAL) [DSC]; BERBERINE (CONSTITUENT OF GOLDENSEAL); inverted exclamation markY97\\%; YBHILYKTIRIUTE-UHFFFAOYSA-N; Berberine hydrogen sulfate; BERBERINE [WHO-DD]; BERBERINE [VANDF]; BERBERINE [MART.]; Prestwick3_000586; Prestwick0_000586; Prestwick1_000586; Prestwick2_000586; Umbellatine (6CI); BERBERINE (MART.); Spectrum2_000894; Spectrum4_000785; Spectrum5_001458; Spectrum3_000618; BCBcMAP01_000112; berberine dimer; UNII-0I8Y3P32UF; Coptis rhizome; BERBERINE [MI]; DivK1c_000265; MEGxp0_001923; BPBio1_000476; NCI60_001050; ACon1_001957; KBio2_004158; KBio2_001590; KBio3_001656; NCI60_001224; NCI60_004319; KBio1_000265; KBio2_006726; IDI1_000265; Umbellatine; Berbericine; SMP1_000298; 0I8Y3P32UF; Umbellatin; 34MD1011DM; Berberone; Berberine; C20H18NO4; Berbinium; Thalsine; Majarine; Berberin; Berberal; BER; Berberine



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(3)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

  • berberine biosynthesis: (S)-tetrahydrocolumbamine + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ (S)-canadine + H2O + an oxidized [NADPH-hemoprotein reductase]
  • (R)-canadine biosynthesis: 7,8-dihydroberberine + H+ + NADPH ⟶ (R)-canadine + NADP+

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(3)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

671 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, CTNNB1, IRS1, JAK2, MAPK14, PCSK9, PPARG, PRKAA2, PTEN, RPL36A, SIRT1, TP53, VEGFA
Peripheral membrane protein 2 ACHE, JAK2
Endosome membrane 2 INSR, LDLR
Endoplasmic reticulum membrane 1 CD4
Nucleus 11 ACHE, CTNNB1, IRS1, JAK2, MAPK14, PPARG, PRKAA2, PTEN, SIRT1, TP53, VEGFA
autophagosome 1 MAP1LC3A
cytosol 11 CTNNB1, IRS1, JAK2, MAP1LC3A, MAPK14, PPARG, PRKAA2, PTEN, RPL36A, SIRT1, TP53
dendrite 1 PRKAA2
centrosome 2 CTNNB1, TP53
nucleoplasm 9 CTNNB1, IRS1, JAK2, MAPK14, PPARG, PRKAA2, PTEN, SIRT1, TP53
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 6 ABCB1, ACHE, CD4, CTNNB1, INSR, LDLR
Lipid-anchor 1 MAP1LC3A
lamellipodium 1 CTNNB1
Multi-pass membrane protein 1 ABCB1
Synapse 2 ACHE, CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
cell surface 5 ABCB1, ACHE, LDLR, PCSK9, VEGFA
glutamatergic synapse 4 CTNNB1, JAK2, MAP1LC3A, MAPK14
Golgi apparatus 6 ACHE, LDLR, PCSK9, PRKAA2, SI, VEGFA
lysosomal membrane 1 PCSK9
neuromuscular junction 1 ACHE
neuronal cell body 1 PRKAA2
postsynapse 1 JAK2
presynaptic membrane 1 CTNNB1
Lysosome 3 INSR, LDLR, PCSK9
endosome 1 PCSK9
plasma membrane 13 ABCB1, ACHE, BCHE, CD4, CTNNB1, INSR, IRS1, JAK2, LDLR, PCSK9, PTEN, RPL36A, SI
Membrane 10 ABCB1, ACHE, CTNNB1, INSR, JAK2, LDLR, PRKAA2, SI, TP53, VEGFA
apical plasma membrane 3 ABCB1, PTEN, SI
axon 2 INSR, PRKAA2
basolateral plasma membrane 2 CTNNB1, LDLR
brush border 1 SI
caveola 3 INSR, IRS1, JAK2
extracellular exosome 4 ABCB1, CTNNB1, INSR, SI
endoplasmic reticulum 4 PCSK9, RPL36A, TP53, VEGFA
extracellular space 4 ACHE, BCHE, PCSK9, VEGFA
perinuclear region of cytoplasm 4 ACHE, CTNNB1, PCSK9, PPARG
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CTNNB1, VEGFA
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 3 MAPK14, SIRT1, TP53
protein-containing complex 2 CTNNB1, TP53
intracellular membrane-bounded organelle 3 IRS1, MAP1LC3A, PPARG
postsynaptic density 1 PTEN
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 3 CD4, INSR, LDLR
Secreted 4 ACHE, BCHE, PCSK9, VEGFA
extracellular region 6 ACHE, BCHE, MAPK14, PCSK9, PTEN, VEGFA
cytoplasmic side of plasma membrane 2 JAK2, PTEN
Single-pass membrane protein 1 LDLR
neuronal cell body membrane 1 INSR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
Extracellular side 1 ACHE
transcription regulator complex 2 CTNNB1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
external side of plasma membrane 3 CD4, INSR, LDLR
Secreted, extracellular space, extracellular matrix 1 VEGFA
low-density lipoprotein particle 1 LDLR
dendritic spine 1 PTEN
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 2 SIRT1, TP53
Wnt signalosome 1 CTNNB1
Early endosome 3 CD4, LDLR, PCSK9
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 2 CTNNB1, LDLR
cell-cell junction 1 CTNNB1
clathrin-coated pit 1 LDLR
COPII-coated ER to Golgi transport vesicle 1 PCSK9
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 ABCB1
heterochromatin 1 SIRT1
Membrane raft 2 CD4, JAK2
Cytoplasm, cytoskeleton 3 CTNNB1, MAP1LC3A, TP53
focal adhesion 2 CTNNB1, JAK2
microtubule 1 MAP1LC3A
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 1 VEGFA
basement membrane 1 ACHE
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 3 PTEN, SIRT1, TP53
PML body 3 PTEN, SIRT1, TP53
secretory granule 1 VEGFA
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 2 MAPK14, PRKAA2
nuclear inner membrane 1 SIRT1
Late endosome 4 INSR, LDLR, MAP1LC3A, PCSK9
receptor complex 3 INSR, LDLR, PPARG
Cell projection, neuron projection 1 PTEN
neuron projection 1 PTEN
chromatin 3 PPARG, SIRT1, TP53
Cytoplasmic vesicle, autophagosome membrane 1 MAP1LC3A
autophagosome membrane 1 MAP1LC3A
cell projection 1 PTEN
cell periphery 1 CTNNB1
cytoskeleton 1 JAK2
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 2 CTNNB1, MAPK14
blood microparticle 1 BCHE
postsynaptic density, intracellular component 1 CTNNB1
Lipid-anchor, GPI-anchor 1 ACHE
microvillus membrane 1 CTNNB1
organelle membrane 1 MAP1LC3A
site of double-strand break 1 TP53
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
Endomembrane system 4 CTNNB1, JAK2, LDLR, MAP1LC3A
endosome lumen 1 JAK2
sorting endosome 1 LDLR
cytoplasmic stress granule 1 PRKAA2
euchromatin 3 CTNNB1, JAK2, SIRT1
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 3 BCHE, CD4, PCSK9
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
Schmidt-Lanterman incisure 1 PTEN
beta-catenin-TCF complex 1 CTNNB1
nuclear envelope lumen 1 BCHE
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 2 CD4, LDLR
ribonucleoprotein complex 1 RPL36A
[Isoform 1]: Nucleus 1 TP53
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
synaptic cleft 1 ACHE
protein-DNA complex 1 CTNNB1
external side of apical plasma membrane 1 ABCB1
endolysosome membrane 2 LDLR, PCSK9
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
dendrite membrane 1 INSR
nucleotide-activated protein kinase complex 1 PRKAA2
somatodendritic compartment 1 LDLR
extrinsic component of external side of plasma membrane 1 PCSK9
cytosolic ribosome 1 RPL36A
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
catenin complex 1 CTNNB1
ribosome 1 RPL36A
PCSK9-LDLR complex 2 LDLR, PCSK9
T cell receptor complex 1 CD4
Autolysosome 1 MAP1LC3A
cytosolic large ribosomal subunit 1 RPL36A
insulin receptor complex 2 INSR, IRS1
myelin sheath adaxonal region 1 PTEN
PCSK9-AnxA2 complex 1 PCSK9
[Isoform alpha]: Secreted 1 PTEN
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
[Isoform H]: Cell membrane 1 ACHE
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Mengyuan Bao, Qingru Bu, Min Pan, Ran Xu, Yujie Chen, Yue Yang, Changzhong Wang, Tianming Wang. Coptidis rhizoma extract alleviates oropharyngeal candidiasis by gC1qR-EGFR/ERK/c-fos axis-induced endocytosis of oral epithelial cells. Journal of ethnopharmacology. 2024 Sep; 331(?):118305. doi: 10.1016/j.jep.2024.118305. [PMID: 38729536]
  • Yuan Gao, Yang-Yang Sun, Dong Bai, Xiao-Xia Wu. Mechanism of the components compatibility of Scutellariae Radix and Coptidis Rhizoma on mice with hyperlipidemia by regulating the Cyp4a family. Journal of ethnopharmacology. 2024 Sep; 331(?):118263. doi: 10.1016/j.jep.2024.118263. [PMID: 38677575]
  • Jinqiu Rao, Qing Gao, Na Li, Yuan Wang, Tianwang Wang, Kai Wang, Feng Qiu. Unraveling the enigma: Molecular mechanisms of berberrubine-induced nephrotoxicity reversed by its parent form berberine. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155648. doi: 10.1016/j.phymed.2024.155648. [PMID: 38669970]
  • Chunbin Sun, Shanshan Dong, Weiwei Chen, Jin Li, Enli Luo, Jiacui Ji. Berberine alleviates Alzheimer's disease by regulating the gut microenvironment, restoring the gut barrier and brain-gut axis balance. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155624. doi: 10.1016/j.phymed.2024.155624. [PMID: 38678955]
  • Shunxiao Zhang, Sheng Zhang, Yan Zhang, Hua Wang, Yue Chen, Hao Lu. Activation of NRF2 by epiberberine improves oxidative stress and insulin resistance in T2DM mice and IR-HepG2 cells in an AMPK dependent manner. Journal of ethnopharmacology. 2024 Jun; 327(?):117931. doi: 10.1016/j.jep.2024.117931. [PMID: 38382657]
  • Chengming Wei, Meina Shi, Zi Wang, Wenjian Lan, Na Feng, Fuming Zhang, Jiachen Liu, Jing-Yu Lang, Wanjun Lin, Wenzhe Ma. Epiberberine inhibits bone metastatic breast cancer-induced osteolysis. Journal of ethnopharmacology. 2024 Jun; 327(?):118039. doi: 10.1016/j.jep.2024.118039. [PMID: 38479545]
  • Kaijun Wang, Jie Yin, Jiayi Chen, Jie Ma, Hongbin Si, Diqi Xia. Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155258. doi: 10.1016/j.phymed.2023.155258. [PMID: 38522318]
  • Heba A Gad, Haidy Abbas, Nesrine S El Sayed, Mohamed A Khattab, Mahmoud A El Hassab, Mai Mansour. Berberine loaded thermosensitive lipid nanoparticles: in vitro characterization, in silico study, and in vivo anti-arthritic effect. Journal of liposome research. 2024 Jun; 34(2):303-315. doi: 10.1080/08982104.2023.2273390. [PMID: 37856332]
  • Shaojing He, Hui Li, Qianjie Zhang, Weimin Zhao, Wei Li, Chaohui Dai, Bixia Li, Jinhua Cheng, Shuang Wu, Zhongming Zhou, Jing Yang, Saijiao Li. Berberine alleviates inflammation in polycystic ovary syndrome by inhibiting hyaluronan synthase 2 expression. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155456. doi: 10.1016/j.phymed.2024.155456. [PMID: 38537446]
  • Yunxiang Jiang, Chengzong Han, Hannan Gong, Jiatao Chen, Biao Tang, Min Yang, Qiwei Qin, Shina Wei. Berberine inhibits SGIV replication by suppressing inflammatory response and oxidative stress. Fish & shellfish immunology. 2024 Jun; 149(?):109522. doi: 10.1016/j.fsi.2024.109522. [PMID: 38548190]
  • Tiantai Wu, Huan Zhang, Yang Jin, Ming Zhang, Qing Zhao, Herong Li, Shouli Wang, Yuan Lu, Shuaishuai Chen, Huakang Du, Ting Liu, Weiyu Guo, Wen Liu. The active components and potential mechanisms of Wuji Wan in the treatment of ethanol-induced gastric ulcer: An integrated metabolomics, network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 May; 326(?):117901. doi: 10.1016/j.jep.2024.117901. [PMID: 38341112]
  • Xueyu Pu, Yuanyuan Wang, Xi Wang, Xiaoqing Sang, Miaomiao Jiang, DaWei Qi, Xin Zhao, Rong Chen, Jianwei Li, Xiang Liu, Zhidong Liu, Jian Yang. Lipids Extracted from Mycobacterial Membrane and Enveloped PLGA Nanoparticles for Encapsulating Antibacterial Drugs Elicit Synergistic Antimicrobial Response against Mycobacteria. Molecular pharmaceutics. 2024 May; 21(5):2238-2249. doi: 10.1021/acs.molpharmaceut.3c01001. [PMID: 38622497]
  • Tingting Chen, Gaoxiang Ai, Guihong Liang, Lingfeng Zeng, Di Zhao, Jun Liu, Yaoxing Dou. Mitigation of inflammatory bowel disease-related osteoporosis by oxyberberine: Insights into the RANKL/NF-κB signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May; 174(?):116523. doi: 10.1016/j.biopha.2024.116523. [PMID: 38574627]
  • Yu Li, Haiting Huang, Cuijin Gu, Wenyi Huang, Xianxian Chen, Xiaoting Lu, Aijia You, Sen Ye, Jun Zhong, Yao Zhao, Yu Yan, Chun Li. Film-forming polymer solutions containing cholesterol myristate and berberine mediate pressure ulcer repair via the Wnt/β-catenin pathway. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2024 May; 32(3):279-291. doi: 10.1111/wrr.13158. [PMID: 38353052]
  • Qi Yang, Lili Fan, Erwei Hao, Xiaotao Hou, Jiagang Deng, Zhongshang Xia, Zhengcai Du. Construction of An Oral Bioavailability Prediction Model Based on Machine Learning for Evaluating Molecular Modifications. Journal of pharmaceutical sciences. 2024 May; 113(5):1155-1167. doi: 10.1016/j.xphs.2024.02.026. [PMID: 38430955]
  • Yueheng Tang, Yang Gao, Kexin Nie, Hongzhan Wang, Shen Chen, Hao Su, Wenya Huang, Hui Dong. Jiao-tai-wan and its effective component-berberine improve diabetes and depressive disorder through the cAMP/PKA/CREB signaling pathway. Journal of ethnopharmacology. 2024 Apr; 324(?):117829. doi: 10.1016/j.jep.2024.117829. [PMID: 38296172]
  • Jun-Xia An, Bao-Qi Zhang, Hong-Jie Liang, Zhi-Jun Zhang, Ying-Qian Liu, Shao-Yong Zhang. Antifungal Activity and Putative Mechanism of HWY-289, a Semisynthetic Protoberberine Derivative, against Botrytis cinerea. Journal of agricultural and food chemistry. 2024 Apr; 72(14):7716-7726. doi: 10.1021/acs.jafc.3c08858. [PMID: 38536397]
  • Xiaoyin Zhang, Zhanbo Xiong, Yue He, Nan Zheng, Shengguo Zhao, Jiaqi Wang. Epiberberine: a potential rumen microbial urease inhibitor to reduce ammonia release screened by targeting UreG. Applied microbiology and biotechnology. 2024 Apr; 108(1):289. doi: 10.1007/s00253-024-13131-4. [PMID: 38587649]
  • Ruimin Tian, Xianfeng Liu, Yang Xiao, Lijia Jing, Honglin Tao, Lu Yang, Xianli Meng. Huang-Lian-Jie-Du decoction drug-containing serum inhibits IL-1β secretion from D-glucose and PA induced BV2 cells via autophagy/NLRP3 signaling. Journal of ethnopharmacology. 2024 Apr; 323(?):117686. doi: 10.1016/j.jep.2023.117686. [PMID: 38160864]
  • Wenjuan Ma, Jianglan Long, Linjie Dong, Jian Zhang, Aiting Wang, Yu Zhang, Dan Yan. Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation. Journal of ethnopharmacology. 2024 Apr; 323(?):117752. doi: 10.1016/j.jep.2024.117752. [PMID: 38216099]
  • Guilan Wei, Ning Huang, Mengyao Li, Fengkun Guan, Liping Chen, Yingyi Liao, Xingyu Xie, Yucui Li, Ziren Su, Jiannan Chen, Yuhong Liu. Tetrahydroberberine alleviates high-fat diet-induced hyperlipidemia in mice via augmenting lipoprotein assembly-induced clearance of low-density lipoprotein and intermediate-density lipoprotein. European journal of pharmacology. 2024 Apr; 968(?):176433. doi: 10.1016/j.ejphar.2024.176433. [PMID: 38369273]
  • Fanjiao Zuo, Boyao Wang, Lizhi Wang, Jun He, Xilong Qiu. UV-Triggered Drug Release from Mesoporous Titanium Nanoparticles Loaded with Berberine Hydrochloride: Enhanced Antibacterial Activity. Molecules (Basel, Switzerland). 2024 Apr; 29(7):. doi: 10.3390/molecules29071607. [PMID: 38611885]
  • Reem S Alruhaimi, Maisa Siddiq Abduh, Ahmad F Ahmeda, Albandari Bin-Ammar, Emadeldin M Kamel, Emad H M Hassanein, Chen Li, Ayman M Mahmoud. Berberine attenuates inflammation and oxidative stress and modulates lymphocyte E-NTPDase in acute hyperlipidemia. Drug development research. 2024 Apr; 85(2):e22166. doi: 10.1002/ddr.22166. [PMID: 38424708]
  • Shweta Sharma, Manisha Mahanty, Suneha G Rahaman, Pritha Mukherjee, Bidisha Dutta, Mohammad Imran Khan, Karunakaran Reddy Sankaran, Xiaoming He, Lakshmyya Kesavalu, Wei Li, Shaik O Rahaman. Avocado-derived extracellular vesicles loaded with ginkgetin and berberine prevent inflammation and macrophage foam cell formation. Journal of cellular and molecular medicine. 2024 Apr; 28(7):e18177. doi: 10.1111/jcmm.18177. [PMID: 38494843]
  • Yong-Qin Cao, Chao Sun, Jian-Yong Li, Xin Zhou. [Research Progress on the Role of Berberine in Hematologic Malignancies and Its Related Mechanisms --Review]. Zhongguo shi yan xue ye xue za zhi. 2024 Apr; 32(2):639-642. doi: 10.19746/j.cnki.issn.1009-2137.2024.02.048. [PMID: 38660879]
  • Zhi Zuo, Qingju Li, Suqin Zhou, Ran Yu, Caixia Wu, Jiajia Chen, Yao Xiao, Haoyu Chen, Jian Song, Yan Pan, Wanpeng Wang. Berberine ameliorates contrast-induced acute kidney injury by regulating HDAC4-FoxO3a axis-induced autophagy: In vivo and in vitro. Phytotherapy research : PTR. 2024 Apr; 38(4):1761-1780. doi: 10.1002/ptr.8059. [PMID: 37922559]
  • Farzaneh Shakeri, Sahar Kiani, Golnoosh Rahimi, Mohammad Hossein Boskabady. Anti-inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review. Phytotherapy research : PTR. 2024 Apr; 38(4):1882-1902. doi: 10.1002/ptr.8077. [PMID: 38358731]
  • Si Shen, Xiaobo Qu, Yinyin Liu, Mengmeng Wang, Haifeng Zhou, Hongmei Xia. Evaluation of Antioxidant Activity and Treatment of Eczema by Berberine Hydrochloride-Loaded Liposomes-in-Gel. Molecules (Basel, Switzerland). 2024 Mar; 29(7):. doi: 10.3390/molecules29071566. [PMID: 38611845]
  • Abdelkader A Metwally, Samayita Ganguly, Nora Biomi, Mingyi Yao, Tamer Elbayoumi. Cationic Vitamin E-TPGS Mixed Micelles of Berberine to Neutralize Doxorubicin-Induced Cardiotoxicity via Amelioration of Mitochondrial Dysfunction and Impeding Apoptosis. Molecules (Basel, Switzerland). 2024 Mar; 29(5):. doi: 10.3390/molecules29051155. [PMID: 38474668]
  • Micaela Paula Del Gaudio, Scheila Iria Kraus, Thayza Martins Melzer, Pamela Soledad Bustos, María Gabriela Ortega. Oral treatment with Berberine reduces peripheral nociception: Possible interaction with different nociceptive pathways activated by different allogeneic substances. Journal of ethnopharmacology. 2024 Mar; 321(?):117504. doi: 10.1016/j.jep.2023.117504. [PMID: 38061440]
  • Qilong Nie, Mingyang Li, Caiyang Huang, Yongwei Yuan, Qiuyan Liang, Xiaojun Ma, Tengyu Qiu, Jianhong Li. The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review. Journal of translational medicine. 2024 Mar; 22(1):225. doi: 10.1186/s12967-024-05011-2. [PMID: 38429794]
  • Tomasz Tuzimski, Anna Petruczynik, Barbara Kaproń, Tomasz Plech, Anna Makuch-Kocka, Daria Janiszewska, Mateusz Sugajski, Bogusław Buszewski, Małgorzata Szultka-Młyńska. In Vitro and In Silico of Cholinesterases Inhibition and In Vitro and In Vivo Anti-Melanoma Activity Investigations of Extracts Obtained from Selected Berberis Species. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29051048. [PMID: 38474561]
  • Ruizhi Lai, Zhiqian Lin, Chunyan Yang, Li Hai, Zhongzhen Yang, Li Guo, Ruifang Nie, Yong Wu. Novel berberine derivatives as p300 histone acetyltransferase inhibitors in combination treatment for breast cancer. European journal of medicinal chemistry. 2024 Feb; 266(?):116116. doi: 10.1016/j.ejmech.2023.116116. [PMID: 38215590]
  • Xuanxuan Cheng, Yuehua Zhu, Jiahuan Huang, Yufei Li, Xiaolin Jiang, Quan Yang. A neutral polysaccharide from Persicaria hydropiper (L.) Spach ameliorates lipopolysaccharide-induced intestinal barrier injury via regulating the gut microbiota and modulating AKT/PI3K/mTOR and MAPK signaling pathways. Journal of ethnopharmacology. 2024 Feb; 320(?):117403. doi: 10.1016/j.jep.2023.117403. [PMID: 37952732]
  • Li Zhang, Min Tan, Jing Mao, Juan Zhang, Xiao-Yuan Wang, Yan Zhang, Rui-Xue Duo, Jia-Yao Hao, Hai-Li Shen. Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis. Clinical rheumatology. 2024 Feb; ?(?):. doi: 10.1007/s10067-024-06871-1. [PMID: 38305937]
  • Chen Chen, Maomei Xie, Yueling Yan, Yongyuan Li, Zhiyao Li, Tong Zhang, Zanyan Gao, Liyi Deng, Haixia Wang. Preparation of berberine hydrochloride-Ag nanoparticle composite antibacterial dressing based on 3D printing technology. Journal of biomaterials applications. 2024 Feb; 38(7):808-820. doi: 10.1177/08853282231222191. [PMID: 38086527]
  • Xinyue Lin, Juanhong Zhang, Yajun Chu, Qiuying Nie, Junmin Zhang. Berberine prevents NAFLD and HCC by modulating metabolic disorders. Pharmacology & therapeutics. 2024 Feb; 254(?):108593. doi: 10.1016/j.pharmthera.2024.108593. [PMID: 38301771]
  • Hongzhan Wang, Shen Chen, Yueheng Tang, Kexin Nie, Yang Gao, Zhi Wang, Hao Su, Fan Wu, Jing Gong, Ke Fang, Hui Dong, Meilin Hu. Berberine promotes lacteal junction zippering and ameliorates diet-induced obesity through the RhoA/ROCK signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155268. doi: 10.1016/j.phymed.2023.155268. [PMID: 38176265]
  • Tao Yang, Niping Qin, Fahui Liu, Yihan Zhao, Wanning Liu, Daiming Fan. Berberine regulates intestinal microbiome and metabolism homeostasis to treat ulcerative colitis. Life sciences. 2024 Feb; 338(?):122385. doi: 10.1016/j.lfs.2023.122385. [PMID: 38184271]
  • Acharya Balkrishna, Ashwani Kumar, Akansha Rohela, Vedpriya Arya, Ajay Kumar Gautam, Hemant Sharma, Priyanka Rai, Amita Kumari, Ryszard Amarowicz. Traditional uses, hepatoprotective potential, and phytopharmacology of Tinospora cordifolia: a narrative review. The Journal of pharmacy and pharmacology. 2024 Jan; ?(?):. doi: 10.1093/jpp/rgae013. [PMID: 38280221]
  • Jinsheng Li, Xueli Hou, Jinlong Xiao, Li Zhu, Yujie Deng, Ziyi Li, Zijian Zhao, Zhenghong Luo, Hao Wei. Synthesis of New Derivatives of Berberine Canagliflozin and Study of Their Antibacterial Activity and Mechanism. Molecules (Basel, Switzerland). 2024 Jan; 29(1):. doi: 10.3390/molecules29010273. [PMID: 38202855]
  • Junya Hu, Huijie Duan, Junqing Zou, Wangli Ding, Ziqiao Wei, Qiang Peng, Zhongyuan Li, Rui Duan, Jianguo Sun, Junrong Zhu. METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes. Aging. 2024 Jan; 16(1):299-321. doi: 10.18632/aging.205369. [PMID: 38180752]
  • Fangqiu Xu, Chuyu Shen, Shuoyang Zhang, Yingli Liu, Di Liu, Yu Kuang, Ruiru Li, Cuicui Wang, Xiaoyan Cai, Maohua Shi, Youjun Xiao. Coptisine inhibits aggressive and proliferative actions of fibroblast like synoviocytes and exerts a therapeutic potential for rheumatoid arthritis. International immunopharmacology. 2024 Jan; 128(?):111433. doi: 10.1016/j.intimp.2023.111433. [PMID: 38181676]
  • Lan Wu, Xiang-Jian Meng, Tian-Bao Xu, Xian-Cui Zhang, Yong Zhou, Zhu-Feng Tong, Jing-Han Jiang. Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. Chemical biology & drug design. 2024 01; 103(1):e14420. doi: 10.1111/cbdd.14420. [PMID: 38230770]
  • Morteza Akhzari, Sajad Jalili, Sajad Rashno, Masoumeh Akmali, Hossein Foruozandeh, Mahdi Barazesh. Evaluation of the Antioxidant Effects of Berberine against Sodium Nitriteinduced Oxidative Injury in the Rat Liver. Current drug safety. 2024; 19(1):51-60. doi: 10.2174/1574886318666230119093541. [PMID: 36655525]
  • Leila Soltani, Hori Ghaneialvar, Naser Abbasi, Parvaneh Bayat, Maryam Nazari. Chitosan/alginate scaffold enhanced with Berberis vulgaris extract for osteocyte differentiation of ovine fetal stem cells. Cell biochemistry and function. 2024 Jan; 42(1):e3924. doi: 10.1002/cbf.3924. [PMID: 38269507]
  • Yueheng Tang, Hao Su, Kexin Nie, Hongzhan Wang, Yang Gao, Shen Chen, Fuer Lu, Hui Dong. Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):116012. doi: 10.1016/j.biopha.2023.116012. [PMID: 38113631]
  • Hongyu Li, Wenna Yang, Xiongzhi Wu, Luyao Tian, Weimei Zhang, Hongyue Tian, Xu Liang, Luqi Huang, Lanping Guo, Xia Li, Wenyuan Gao. Cationic fructan-based pH and intestinal flora dual stimulation nanoparticle with berberine for targeted therapy of IBD. International journal of biological macromolecules. 2024 Jan; 256(Pt 2):127987. doi: 10.1016/j.ijbiomac.2023.127987. [PMID: 37979767]
  • Zhaoxia Tang, Jiali Luo, Yahya Faqir, Yu Zhang, Wenqian Xue, Hongmei Zhao, Ali Murad Jakhar, Chengjia Tan, Jiahua Ma. Berberine hydrochloride-loaded dung beetle chitosan/sodium alginate microspheres ameliorate DSS-induced colitis and regulate gut microorganisms in mice. International journal of biological macromolecules. 2024 Jan; 255(?):128219. doi: 10.1016/j.ijbiomac.2023.128219. [PMID: 37981270]
  • Zizhen Huang, Jie Wang, Hui Chen, Ruofei Feng, Chunxia Tan. The interaction on HSA and the antibacterial activity from four polyoxometalate hybrids based on berberine. Nucleosides, nucleotides & nucleic acids. 2024; 43(2):156-172. doi: 10.1080/15257770.2023.2243292. [PMID: 37574837]
  • Wanpeng Wang, Ran Yu, Caixia Wu, Qingju Li, Jiajia Chen, Yao Xiao, Haoyu Chen, Jian Song, Mingyue Ji, Zhi Zuo. Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway. Journal of cellular and molecular medicine. 2024 01; 28(1):e18016. doi: 10.1111/jcmm.18016. [PMID: 37909687]
  • Chenqi Chang, Heng Liu, Xiaotong Li, Dandan Song, Yue Liu, Chang Lu, Yu Zhen, Ying Chen, Jinguo Xu, Weidong Li, Xiaobin Jia, Zhipeng Chen, Rui Chen. Combined ROS Responsive Polydopamine-Coated Berberine Nanoparticles Effective Against Ulcerative Colitis in Mouse Model. International journal of nanomedicine. 2024; 19(?):1205-1224. doi: 10.2147/ijn.s442761. [PMID: 38348171]
  • Gamal Shams, Somia Abd Allah, Raghda Ezzat, Mahmoud A Said. Ameliorative effects of berberine and selenium against paracetamol-induced hepatic toxicity in rats. Open veterinary journal. 2024 Jan; 14(1):292-303. doi: 10.5455/ovj.2024.v14.i1.26. [PMID: 38633147]
  • Chih-Hsin Lin, Yih-Ru Wu, Chih-Ying Chao, Kuo-Hsuan Chang, Chiung-Mei Chen, Wan-Ling Chen, Pei-Ning Yang, Guey-Jen Lee-Chen. Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells. Biological & pharmaceutical bulletin. 2024; 47(4):827-839. doi: 10.1248/bpb.b23-00758. [PMID: 38599826]
  • Wei Xiong, Lingmei Yuan, Liangxia Wang, Guowen Qian, Chaoyi Liang, Bin Pan, Ling Guo, Wenqiang Wei, Xunxiang Qiu, Wenfang Deng, Zhikui Zeng. [Preparation of berberine-naringin dual drug-loaded composite microspheres and evaluation of their antibacterial-osteogenic properties]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. 2023 Dec; 37(12):1505-1513. doi: 10.7507/1002-1892.202308054. [PMID: 38130195]
  • Chang Wang, Yitian Yang, Jinyan Chen, Xueyan Dai, Chenghong Xing, Caiying Zhang, Huabin Cao, Xiaoquan Guo, Guoliang Hu, Yu Zhuang. Berberine Protects against High-Energy and Low-Protein Diet-Induced Hepatic Steatosis: Modulation of Gut Microbiota and Bile Acid Metabolism in Laying Hens. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417304. [PMID: 38139133]
  • Jinci Yan, Chengli Fang, Gaohua Yang, Jianxu Li, Yanqiang Liu, Lu Zhang, Pengjie Yang, Jingyuan Fang, Yang Gu, Yu Zhang, Weihong Jiang. Identification of FtfL as a novel target of berberine in intestinal bacteria. BMC biology. 2023 12; 21(1):280. doi: 10.1186/s12915-023-01778-w. [PMID: 38049785]
  • Soo Im Chang, Doug-Young Ryu. Assessment of subchronic toxicity and toxicokinetics of AG NPP709 in Sprague-Dawley rats. Journal of ethnopharmacology. 2023 Dec; 317(?):116801. doi: 10.1016/j.jep.2023.116801. [PMID: 37330073]
  • Yi Chen, Qi Li, Shiwei Zhao, Lei Sun, Zequn Yin, Xiaolin Wang, Xiaoju Li, Yasuko Iwakiri, Jihong Han, Yajun Duan. Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis. Biochemical pharmacology. 2023 12; 218(?):115928. doi: 10.1016/j.bcp.2023.115928. [PMID: 37979703]
  • Yan-Nan Hu, Zhen-Ye Luo, Chang-Shun Liu, Ting Xia, Feng-Lin Zhang, Fei-Long Chen, Xiao-Mei Tan. [Excretion of three alkaloids from Simiao Pills in urine, feces, and bile between normal and type 2 diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Dec; 48(23):6509-6518. doi: 10.19540/j.cnki.cjcmm.20230616.202. [PMID: 38212008]
  • Fan Wu, Mingyu Cui, Siwen Wang, Chao Yu, Weihong Yin, Jiao Li, Xueying Yan. Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats. Xenobiotica; the fate of foreign compounds in biological systems. 2023 Dec; 53(12):644-652. doi: 10.1080/00498254.2023.2290648. [PMID: 38054840]
  • Shan Gao, Haocheng Zheng, Shujing Xu, Jingwei Kong, Feng Gao, Zhijia Wang, Yuan Li, Ziqi Dai, Xinqi Jiang, Xia Ding, Haimin Lei. Novel Natural Carrier-Free Self-Assembled Nanoparticles for Treatment of Ulcerative Colitis by Balancing Immune Microenvironment and Intestinal Barrier. Advanced healthcare materials. 2023 Dec; 12(31):e2301826. doi: 10.1002/adhm.202301826. [PMID: 37681364]
  • Tingting Lu, Yu Wang, Fang Liu, Lu Zhang, Simin Huang, Yuanyuan Zhou, Hui Wu, Yanmei Mao, Chufeng Jin, Wencheng Song. Synergistic Inhibitory Effect of Berberine and Low-Temperature Plasma on Non-Small-Cell Lung Cancer Cells via PI3K-AKT-Driven Signaling Axis. Molecules (Basel, Switzerland). 2023 Nov; 28(23):. doi: 10.3390/molecules28237797. [PMID: 38067530]
  • Junming Zhang, Jianhao Song, Haobo Li, Zhaoxia Li, Mengyu Chen, Shutao Ma, Rong Shen, Xiangxin Lou. Berberine protects against neomycin-induced ototoxicity by reducing ROS generation and activating the PI3K/AKT pathway. Neuroscience letters. 2023 Nov; 817(?):137518. doi: 10.1016/j.neulet.2023.137518. [PMID: 37844727]
  • Han-Young Kim, Jung-Hoon Kim. Chemical Characterization of the Precipitate Found in and Its Effect on Drug Release of the Scutellaria baicalensis -Coptis chinensis Extract. Chemistry & biodiversity. 2023 Nov; ?(?):e202301461. doi: 10.1002/cbdv.202301461. [PMID: 37961037]
  • Nguyen Hong Van, Le Nguyen Manh Khoa, Nguyen Chau Ngoc Mai. Spray-dried Solid Lipid Nanoparticles for Enhancing Berberine Bioavailability via Oral Administration. Current pharmaceutical design. 2023 Nov; ?(?):. doi: 10.2174/0113816128263982231102062745. [PMID: 37961862]
  • Shufa Tan, Yan Ou, Yunyi Yang, Shuilan Huang, Shikai Chen, Qiangqiang Gao. Preventive effects of chemical drugs on recurrence of colorectal adenomas: systematic review and Bayesian network meta-analysis. European journal of gastroenterology & hepatology. 2023 Nov; ?(?):. doi: 10.1097/meg.0000000000002676. [PMID: 37942763]
  • Mohammad Rafi Khezri, Somayeh Mohammadipanah, Morteza Ghasemnejad-Berenji. The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3-kinase/AKT signaling pathway. Phytotherapy research : PTR. 2023 Nov; ?(?):. doi: 10.1002/ptr.8040. [PMID: 37922566]
  • Fernanda Vitória Leimann, Luma Borges de Souza, Byanca Pereira Moreira de Oliveira, Bruna Franzon Rossi, Patrícia Sabino da Silva, Carlos Seiti Hurtado Shiraishi, Vanessa Kaplum, Rui Miguel Abreu, Carla Pereira, Lillian Barros, Ana Paula Peron, Rafael Porto Ineu, Bruno Francisco Oechsler, Claudia Sayer, Pedro Henrique Hermes de Araújo, Odinei Hess Gonçalves. Evaluation of berberine nanoparticles as a strategy to modulate acetylcholinesterase activity. Food research international (Ottawa, Ont.). 2023 Nov; 173(Pt 1):113295. doi: 10.1016/j.foodres.2023.113295. [PMID: 37803607]
  • Dongming Zheng, Daifan Yue, Jinyang Shen, Dongmei Li, Zhen Song, Yifu Huang, Jiangyan Yong, Yan Li. Berberine inhibits Candida albicans growth by disrupting mitochondrial function through the reduction of iron absorption. Journal of applied microbiology. 2023 Nov; 134(11):. doi: 10.1093/jambio/lxad276. [PMID: 37994672]
  • Xiangli He, Jiayan Cui, Hui Ma, Naijipu Abuduaini, Ying Huang, Lu Tang, Wanyan Wang, Yuanyuan Zhang, Yang Wang, Weiqiang Lu, Bo Feng, Jin Huang. Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer. Biochemical pharmacology. 2023 Oct; 218(?):115868. doi: 10.1016/j.bcp.2023.115868. [PMID: 37871880]
  • Panpan Chen, Yuhao Han, Lei Wang, Yurong Zheng, Zihan Zhu, Yuan Zhao, Mingqi Zhang, Xiangfeng Chen, Xiao Wang, Chenglong Sun. Spatially Resolved Metabolomics Combined with the 3D Tumor-Immune Cell Coculture Spheroid Highlights Metabolic Alterations during Antitumor Immune Response. Analytical chemistry. 2023 10; 95(41):15153-15161. doi: 10.1021/acs.analchem.2c05734. [PMID: 37800909]
  • Mei Ye, Guangxian Liu, Yujun Yang, Hongyu Yang, Juan Ren, Wenfei Chen, Zeli Gao. Network pharmacology and experimental verification of the potential mechanism of Er-Xian decoction in aplastic anemia. Scientific reports. 2023 Oct; 13(1):17385. doi: 10.1038/s41598-023-44672-9. [PMID: 37833363]
  • Chunyi Xu, Linxian Zhao, Weiling Zhou, Yanyan Li, Huiling Hu, Zhanguo Wang. Synergistic effect of berberine hydrochloride and dehydrocostus lactone in the treatment of ulcerative colitis: Take gut microbiota as the target. International immunopharmacology. 2023 Oct; 124(Pt B):111009. doi: 10.1016/j.intimp.2023.111009. [PMID: 37820424]
  • Nekpen Erhunse, Surekha Kumari, Anmol, Pooja Singh, Ehimwenma Sheena Omoregie, Agam Prasad Singh, Upendra Sharma, Dinkar Sahal. Annickia affinis (Exell) Versteegh & Sosef methanol stembark extract, potent fractions and isolated Berberine alkaloid target both blood and liver stages of Plasmodiumfalciparum. Journal of ethnopharmacology. 2023 Oct; ?(?):117269. doi: 10.1016/j.jep.2023.117269. [PMID: 37813288]
  • Ziwei Huang, Minhua Li, Zehui Qin, Xingdong Ma, Ronglei Huang, Yuhong Liu, Jianhui Xie, Huifang Zeng, Ruoting Zhan, Ziren Su. Intestines-erythrocytes-mediated bio-disposition deciphers the hypolipidemic effect of berberine from Rhizoma Coptidis: A neglected insight. Journal of ethnopharmacology. 2023 Oct; 314(?):116600. doi: 10.1016/j.jep.2023.116600. [PMID: 37196811]
  • Md Abdur Rashid Mia, Dipta Dey, Musfiqur Rahman Sakib, Md Yeaman Biswas, Abdullah Al Shamsh Prottay, Niloy Paul, Fahmida Hoque Rimti, Yusuf Abdullah, Partha Biswas, Md Iftehimul, Priyanka Paul, Chandan Sarkar, Heba A S El-Nashar, Mohamed El-Shazly, Muhammad Torequl Islam. The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities. Phytotherapy research : PTR. 2023 Oct; ?(?):. doi: 10.1002/ptr.8017. [PMID: 37786304]
  • Jian-Hua Ming, Ting Wang, Ting-Hui Wang, Jin-Yun Ye, Yi-Xiang Zhang, Xia Yang, Xian-Ping Shao, Zhong-Ying Ding. Effects of dietary berberine on growth performance, lipid metabolism, antioxidant capacity and lipometabolism-related genes expression of AMPK signaling pathway in juvenile black carp (Mylopharyngodon piceus) fed high-fat diets. Fish physiology and biochemistry. 2023 Oct; 49(5):769-786. doi: 10.1007/s10695-022-01143-8. [PMID: 36418662]
  • Han Shuai, Mao Hua, Jin Tingting, Yan Rubing, Wang Ziyi, Zhang Jie, Shi Jianwen, Liang Yongxin. Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 10; 43(5):915-924. doi: 10.19852/j.cnki.jtcm.20230802.006. [PMID: 37679979]
  • Xiaolei Ma, Xiaoyou Yu, Rui Li, Jinjin Cui, Haoyang Yu, Ling Ren, Jiandong Jiang, Wenxuan Zhang, Lulu Wang. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. Journal of ethnopharmacology. 2023 Sep; 319(Pt 2):117238. doi: 10.1016/j.jep.2023.117238. [PMID: 37774895]
  • Limin Pan, Yaolei Wang, Ruiqian Guan, Qingchun Shi. Study on the active ingredients and mechanism of Jiaotai Pill in the treatment of primary insomnia based on network pharmacology and GEO statistics: A review. Medicine. 2023 Sep; 102(38):e35253. doi: 10.1097/md.0000000000035253. [PMID: 37747012]
  • Meng Zhao, Ting Xiang, Zhikui Dong, Guorui Liu, Pengran Wang, Xiaoxu Qi, Qingqing Hao, Na Han, Zhihui Liu, Sikai Li, Jun Yin, Jianxiu Zhai. Shenqu xiaoshi oral solution enhances digestive function and stabilizes the gastrointestinal microbiota of juvenile rats with infantile anorexia. Journal of ethnopharmacology. 2023 Sep; 319(Pt 1):117112. doi: 10.1016/j.jep.2023.117112. [PMID: 37739107]
  • Bowan Huang, Gengzhi Wen, Rujia Li, Minhua Wu, Zhenning Zou. Integrated network pharmacology, bioinformatics, and molecular docking to explore the mechanisms of berberine regulating autophagy in breast cancer. Medicine. 2023 Sep; 102(36):e35070. doi: 10.1097/md.0000000000035070. [PMID: 37682166]
  • Xue Zhong, Huiwen Deng, Min Long, Honglu Yin, Qiu Zhong, Shilong Zheng, Tao Gong, Ling He, Guangdi Wang, Qiu Sun. Discovery of berberine analogs as potent and highly selective p300/CBP HAT inhibitors. Bioorganic chemistry. 2023 09; 138(?):106597. doi: 10.1016/j.bioorg.2023.106597. [PMID: 37245245]
  • Dongya Chen, Jingfang Xiong, Gaofeng Chen, Zhaolin Zhang, Yihui Liu, Jianjun Xu, Hong Xu. Comparing the Influences of Metformin and Berberine on the Intestinal Microbiota of Rats With Nonalcoholic Steatohepatitis. In vivo (Athens, Greece). 2023 Sep; 37(5):2105-2127. doi: 10.21873/invivo.13308. [PMID: 37652508]
  • Kang Wang, Pei Liu, Si-Fan Wang, Jie-Yu Zhang, Zhi-Zhi Hu, Yu-Qi Mei, Ying-Bo Yang, Zheng-Tao Wang, Li Yang. [Quality evaluation of Compound Cheqian Tablets based on UPLC-Q-TOF-MS/MS, network pharmacology and "double external standards" QAMS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Sep; 48(17):4675-4685. doi: 10.19540/j.cnki.cjcmm.20230605.302. [PMID: 37802806]
  • Han Xiao, Li Xie, Yili Ma, Shilin Fu, Maoyang Guo, Dehui Qian. Molecular Mechanism of Berberine in the Treatment of Calcified Aortic Valve Disease Based on AGE-RAGE Signal Pathway. Alternative therapies in health and medicine. 2023 Sep; ?(?):. doi: . [PMID: 37652411]
  • Lei Wang, Jiaoyang Wang, Guoqing Ren, Siyang Sun, Kazuo Nishikawa, Jing Yu, Chaofeng Zhang. Ameliorative effects of the Coptis inflorescence extract against lung injury in diabetic mice by regulating AMPK/NEU1 signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 118(?):154963. doi: 10.1016/j.phymed.2023.154963. [PMID: 37516057]
  • Vida V Ruiz-Herrera, Shaúl A Navarro-Lara, Jaime F Andrade-Villanueva, Monserrat Alvarez-Zavala, Karina Sánchez-Reyes, Marcela Toscano-Piña, Anibal S Méndez-Clemente, Pedro Martínez-Ayala, Adriana Valle-Rodríguez, Luz A González-Hernández. Pilot study on the efficacy and safety of berberine in people with metabolic syndrome and human immunodeficiency virus infection. International journal of STD & AIDS. 2023 Aug; ?(?):9564624231196600. doi: 10.1177/09564624231196600. [PMID: 37611246]
  • Lu Yang, Yuzhen Huang, Fengxi Chen, Yan Wang, Kunhan Su, Ming Zhao, Weiwei Tao, Wanli Liu. Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65. International immunopharmacology. 2023 Aug; 123(?):110808. doi: 10.1016/j.intimp.2023.110808. [PMID: 37595491]
  • Xuemei Wang, Fengni Liang, Zhaoyuan Dai, Xinchi Feng, Feng Qiu. Combination of Coptis chinensis polysaccharides and berberine ameliorates ulcerative colitis by regulating gut microbiota and activating AhR/IL-22 pathway. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117050. doi: 10.1016/j.jep.2023.117050. [PMID: 37595814]
  • Huimin Wu, Xinrui Xie, Qin Tang, Ting Huang, Xiang Tang, Baihua Jiao, Rui Wang, Xinhu Zhu, Xiaoli Ye, Hang Ma, Xuegang Li. Epiberberine inhibits Helicobacter pylori and reduces host apoptosis and inflammatory damage by down-regulating urease expression. Journal of ethnopharmacology. 2023 Aug; ?(?):117046. doi: 10.1016/j.jep.2023.117046. [PMID: 37586440]
  • Victoria O Oyanna, Kenisha Y Garcia-Torres, Baron J Bechtold, Katherine D Lynch, M Ridge Call, Miklós Horváth, Preston K Manwill, Tyler N Graf, Nadja B Cech, Nicholas H Oberlies, Mary F Paine, John D Clarke. Goldenseal-mediated inhibition of intestinal uptake transporters decreases metformin systemic exposure in mice. Drug metabolism and disposition: the biological fate of chemicals. 2023 Aug; ?(?):. doi: 10.1124/dmd.123.001360. [PMID: 37562957]
  • F F Zhou, X M Gu, L Wang, M Lin. [The mechanism of berberine on Methicillin resistant Staphylococcus aureus in vitro]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2023 Aug; 57(8):1217-1221. doi: 10.3760/cma.j.cn112150-20230206-00081. [PMID: 37574315]
  • Guiping Huang, Zhao Yin, Xiuyuan Wang, Ziqi Wen, Rui Su, Chuting Li, Yanjun Liu, Juhua Yang, Haiyan Hu, Hong Nie, Xiaobin Zeng, Jia Fei. System analysis of Huang-Lian-Jie-Du-Tang and their key active ingredients for overcoming CML resistance by suppression of leukemia stem cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Aug; 117(?):154918. doi: 10.1016/j.phymed.2023.154918. [PMID: 37329755]
  • Simon Bernard Iloki Assanga, Lidianys María Lewis Luján, Mark F McCarty. Targeting beta-catenin signaling for prevention of colorectal cancer - Nutraceutical, drug, and dietary options. European journal of pharmacology. 2023 Jul; ?(?):175898. doi: 10.1016/j.ejphar.2023.175898. [PMID: 37481200]
  • Shasha Chen, Weina Shen, Yuhuan Liu, Qiang Dong, Yongquan Shi. Efficacy and safety of triple therapy containing berberine, amoxicillin, and vonoprazan for Helicobacter pylori initial treatment: A randomized controlled trial. Chinese medical journal. 2023 Jul; 136(14):1690-1698. doi: 10.1097/cm9.0000000000002696. [PMID: 37469024]
  • Jia-Wen Shou, Pang-Chui Shaw. Berberine Reduces Lipid Accumulation in Obesity via Mediating Transcriptional Function of PPARδ. International journal of molecular sciences. 2023 Jul; 24(14):. doi: 10.3390/ijms241411600. [PMID: 37511356]
  • Ming-Feng He, Jian-Hui Liang, Yan-Ni Shen, Chao-Wei Zhang, Kuang-Yang Yang, Li-Chu Liu, Qian Xie, Chun Hu, Xun Song, Yan Wang. Coptisine Inhibits Influenza Virus Replication by Upregulating p21. Molecules (Basel, Switzerland). 2023 Jul; 28(14):. doi: 10.3390/molecules28145398. [PMID: 37513270]