4-hydroxyphenylacetate (BioDeep_00000000855)

 

Secondary id: BioDeep_00000265138, BioDeep_00000419023, BioDeep_00000862189

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


2-(4-hydroxyphenyl)acetic acid

化学式: C8H8O3 (152.0473418)
中文名称: 4-羟基苯乙酸, 对羟基苯乙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.16%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

4-hydroxyphenylacetate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/4-hydroxyphenylacetate (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000000855). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC(=CC=C1CC(=O)O)O
InChI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)

描述信息

p-Hydroxyphenylacetic acid, also known as 4-hydroxybenzeneacetate, is classified as a member of the 1-hydroxy-2-unsubstituted benzenoids. 1-Hydroxy-2-unsubstituted benzenoids are phenols that are unsubstituted at the 2-position. p-Hydroxyphenylacetic acid is considered to be slightly soluble (in water) and acidic.  p-Hydroxyphenylacetic acid can be synthesized from acetic acid. It is also a parent compound for other transformation products, including but not limited to, methyl 2-(4-hydroxyphenyl)acetate, ixerochinolide, and lactucopicrin 15-oxalate.  p-Hydroxyphenylacetic acid can be found in numerous foods such as olives, cocoa beans, oats, and mushrooms. p-Hydroxyphenylacetic acid can be found throughout all human tissues and in all biofluids. Within a cell, p-hydroxyphenylacetic acid is primarily located in the cytoplasm and in the extracellular space. p-Hydroxyphenylacetic acid is also a microbial metabolite produced by Acinetobacter, Clostridium, Klebsiella, Pseudomonas, and Proteus. Higher levels of this metabolite are associated with an overgrowth of small intestinal bacteria from Clostridia species including C. difficile, C. stricklandii, C. lituseburense, C. subterminale, C. putrefaciens, and C. propionicum (PMID: 476929, 12173102). p-Hydroxyphenylacetic acid is detected after the consumption of whole grain.
4-hydroxyphenylacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. It has a role as a plant metabolite, a fungal metabolite, a human metabolite and a mouse metabolite. It is a monocarboxylic acid and a member of phenols. It is functionally related to an acetic acid. It is a conjugate acid of a 4-hydroxyphenylacetate.
4-Hydroxyphenylacetic acid is a natural product found in Guanomyces polythrix, Forsythia suspensa, and other organisms with data available.
4-Hydroxyphenylacetic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.
Constituent of sweet clover (Melilotus officinalis) and yeast

Hydroxyphenylacetic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=156-38-7 (retrieved 2024-07-02) (CAS RN: 156-38-7). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].

同义名列表

61 个代谢物同义名

InChI=1/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11; 4-Hydroxyphenylacetic acid, Vetec(TM) reagent grade, 98\\%; 4-10-00-00543 (Beilstein Handbook Reference); 2-[4-(hydroxy)phenyl)acetic acid; 4-Hydroxyphenylacetic acid, 98\\%; 2-(4-(HYDROXY)PHENYL)ACETIC ACID; Acetic acid, (p-hydroxyphenyl)-; (4-Hydroxy-phenyl)-essigsaeure; (4-hydroxy-phenyl)-acetic acid; (4-hydroxyphenyl)ethanoic acid; 2-(4-hydroxyphenyl)acetic acid; benzeneacetic acid, 4-hydroxy-; 4-Hydroxyphenylacetic Acid,(S); (4-hydroxyphenyl)-acetic acid; Acetic acid, 4-hydroxyphenyl-; Parahydroxy phenylacetic acid; (p-hydroxyphenyl)-Acetic acid; (4-hydroxyphenyl) acetic acid; para-hydroxyphenylacetic acid; p-hydroxy phenyl acetic acid; 4-hydroxy-phenyl acetic acid; (4-Hydroxyphenyl)acetic acid; 4-Hydroxybenzene acetic acid; 4-Hydroxy-Benzeneacetic acid; 4-hydroxyphenylethanoic acid; (p-Hydroxyphenyl)acetic acid; 4-hydroxy phenyl acetic acid; 4- hydroxyphenylacetic acid; 4-Hydroxybenzeneacetic acid; 4-Hydroxyphenyl acetic acid; p-Hydroxyphenyl acetic acid; 4-hydroxyphenyl-acetic acid; 4-hydroxy-phenylacetic acid; (4-hydroxy-phenyl)-acetate; 4-Hydroxyphenylacetic acid; p-hydroxyphenylacetic acid; 4-hyroxyphenylacetic acid; Parahydroxy phenylacetate; (p-hydroxyphenyl)-Acetate; 4-hydroxyphenyacetic acid; 4-hydroxyphenylactic acid; (4-Hydroxyphenyl)acetate; 4-Hydroxy-Benzeneacetate; Parahydroxyphenylacetate; (p-hydroxyphenyl)acetate; 4-hydroxybenzeneacetate; 4-(Carboxymethyl)phenol; p-hydroxyphenylacetate; 4-hydroxyphenylacetate; 4-Carboxymethylphenol; UNII-3J9SHG0RCN; ChemDiv3_005483; IDI1_023393; 3J9SHG0RCN; AI3-17755; 4-HPA; 3pcg; HPAA; 1ai6; 4HP; p-Hydroxyphenylacetic acid



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

29 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(2)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(24)

PharmGKB(0)

99 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shaoshuai Xin, Mengqi Zhang, Peihai Li, Lizhen Wang, Xuanming Zhang, Shanshan Zhang, Zhenqiang Mu, Houwen Lin, Xiaobin Li, Kechun Liu. Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish. Marine drugs. 2024 Mar; 22(4):. doi: 10.3390/md22040148. [PMID: 38667765]
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  • Yu-Ping Shen, Yuyang Pan, Fu-Xing Niu, Yu-Ling Liao, Mingtao Huang, Jian-Zhong Liu. Biosensor-assisted evolution for high-level production of 4-hydroxyphenylacetic acid in Escherichia coli. Metabolic engineering. 2022 03; 70(?):1-11. doi: 10.1016/j.ymben.2021.12.008. [PMID: 34965469]
  • Danny Orabi, Lucas J Osborn, Kevin Fung, William Massey, Anthony J Horak, Federico Aucejo, Ibrahim Choucair, Beckey DeLucia, Zeneng Wang, Jan Claesen, J Mark Brown. A surgical method for continuous intraportal infusion of gut microbial metabolites in mice. JCI insight. 2021 05; 6(9):. doi: 10.1172/jci.insight.145607. [PMID: 33986195]
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