Novobiocin (BioDeep_00000410507)

Main id: BioDeep_00000001812

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Novobiocin

化学式: C31H36N2O11 (612.2319)
中文名称: 新生霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCc1cc(ccc1O)C(=O)Nc1c(c2ccc(c(C)c2oc1=O)O[C@H]1[C@@H]([C@@H]([C@H](C(C)(C)O1)OC)OC(=O)N)O)O)C
InChI: InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25+,26-,29-/m1/s1

描述信息

D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
A coumarin-derived antibiotic obtained from Streptomyces niveus.
C254 - Anti-Infective Agent > C258 - Antibiotic
Origin: Microbe, Coumarins
Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity[1][2][3][4][6].

同义名列表

4 个代谢物同义名

Novobiocin; Albamycin; Cathomycin; Novobiocin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

97 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, AKT1, CASP3, CAT, ERBB2, HSP90AA2P, MYC, RAD51, RAF1, TP53
Endosome membrane 1 ERBB2
Endoplasmic reticulum membrane 1 HSP90B1
Mitochondrion membrane 1 ABCG2
Nucleus 11 AKT1, CASP3, ERBB2, HSP90B1, MYC, PARP1, POLQ, RAD51, RAF1, TOP1, TP53
cytosol 12 AKT1, CASP3, CAT, ERBB2, HSP90AA2P, HSP90B1, PARP1, POLQ, PRKCQ, RAD51, RAF1, TP53
mitochondrial membrane 1 ABCG2
nuclear body 1 PARP1
centrosome 2 RAD51, TP53
nucleoplasm 11 ABCG2, AKT1, ATP2B1, CASP3, ERBB2, MYC, PARP1, POLQ, RAD51, TOP1, TP53
Cell membrane 7 ABCB1, ABCG2, AKT1, ATP2B1, ERBB2, RAF1, TNF
lamellipodium 1 AKT1
ruffle membrane 1 ERBB2
Multi-pass membrane protein 4 ABCB1, ABCC2, ABCG2, ATP2B1
Synapse 1 ATP2B1
cell cortex 1 AKT1
cell surface 3 ABCB1, ABCC2, TNF
glutamatergic synapse 3 AKT1, ATP2B1, CASP3
Golgi apparatus 2 POLQ, RAF1
neuromuscular junction 1 ERBB2
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
presynaptic membrane 2 ATP2B1, ERBB2
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 PARP1
plasma membrane 10 ABCB1, ABCC2, ABCG2, AKT1, ATP2B1, ERBB2, HSP90AA2P, PRKCQ, RAF1, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 11 ABCB1, ABCC2, ABCG2, AKT1, ATP2B1, CAT, ERBB2, HSP90B1, MYC, PARP1, TP53
apical plasma membrane 4 ABCB1, ABCC2, ABCG2, ERBB2
basolateral plasma membrane 2 ATP2B1, ERBB2
extracellular exosome 5 ABCB1, ATP2B1, CAT, HSP90AA2P, HSP90B1
endoplasmic reticulum 2 HSP90B1, TP53
extracellular space 1 TNF
perinuclear region of cytoplasm 4 ERBB2, HSP90AA2P, HSP90B1, RAD51
intercellular canaliculus 1 ABCC2
mitochondrion 5 CAT, PARP1, RAD51, RAF1, TP53
protein-containing complex 8 AKT1, CAT, HSP90AA2P, HSP90B1, MYC, PARP1, RAD51, TP53
intracellular membrane-bounded organelle 2 ATP2B1, CAT
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ERBB2
extracellular region 4 CAT, ERBB2, HSP90B1, TNF
mitochondrial outer membrane 1 RAF1
Mitochondrion matrix 2 RAD51, TP53
mitochondrial matrix 3 CAT, RAD51, TP53
transcription regulator complex 2 PARP1, TP53
centriolar satellite 1 PRKCQ
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 RAD51, TP53
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 TNF
perikaryon 1 TOP1
cytoplasmic vesicle 1 ERBB2
microtubule cytoskeleton 1 AKT1
nucleolus 5 MYC, PARP1, RAD51, TOP1, TP53
midbody 1 HSP90B1
P-body 1 TOP1
Early endosome 1 ERBB2
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 3 ABCB1, ABCC2, ABCG2
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 2 ABCG2, TNF
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 CAT, HSP90B1
spindle 1 AKT1
mitochondrial nucleoid 1 POLQ
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 2 RAD51, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 HSP90B1
lateral plasma membrane 1 ATP2B1
receptor complex 1 ERBB2
ciliary basal body 1 AKT1
chromatin 4 MYC, PARP1, RAD51, TP53
cell projection 1 ATP2B1
phagocytic cup 1 TNF
Chromosome 4 PARP1, POLQ, RAD51, TOP1
brush border membrane 1 ABCG2
Nucleus, nucleolus 3 MYC, PARP1, TOP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 2 PARP1, RAD51
nuclear chromosome 1 RAD51
Basolateral cell membrane 1 ATP2B1
site of double-strand break 4 PARP1, POLQ, RAD51, TP53
fibrillar center 1 TOP1
nuclear envelope 2 MYC, PARP1
lateral element 1 RAD51
Nucleus, nucleoplasm 2 MYC, TOP1
Melanosome 1 HSP90B1
Presynaptic cell membrane 1 ATP2B1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 ERBB2
sperm plasma membrane 1 HSP90B1
pseudopodium 1 RAF1
basal plasma membrane 1 ERBB2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 HSP90B1
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
male germ cell nucleus 2 RAD51, TOP1
RNA polymerase II transcription repressor complex 1 MYC
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
condensed nuclear chromosome 1 RAD51
semaphorin receptor complex 1 ERBB2
Sarcoplasmic reticulum lumen 1 HSP90B1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 2 PARP1, TOP1
external side of apical plasma membrane 2 ABCB1, ABCG2
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 ERBB2
Rough endoplasmic reticulum 1 MYC
condensed chromosome 1 RAD51
site of DNA damage 2 PARP1, POLQ
endocytic vesicle lumen 1 HSP90B1
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
ERBB3:ERBB2 complex 1 ERBB2
presynaptic intermediate filament cytoskeleton 1 RAD51
endoplasmic reticulum chaperone complex 1 HSP90B1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
photoreceptor ribbon synapse 1 ATP2B1
nuclear ubiquitin ligase complex 1 RAD51
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • Jinxin Zhang, Lixia Liu, Yan Li, Yaling Huang, Senbo Xiao, Zihao Deng, Zhenming Zheng, Jieyou Li, Manfeng Liang, Guantai Xie, Xiao Chen, Yaotang Deng, Wenchong Tan, Hairou Su, Guibing Wu, Chunqing Cai, Xuemei Chen, Fei Zou. HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma. Neoplasia (New York, N.Y.). 2023 Sep; 44(?):100935. doi: 10.1016/j.neo.2023.100935. [PMID: 37717471]
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