NCBI Taxonomy: 193462

Streptomyces niveus (ncbi_taxid: 193462)

found 14 associated metabolites at species taxonomy rank level.

Ancestor: Streptomyces

Child Taxonomies: Streptomyces niveus NCIMB 11891

Novobiocin

(3R,4S,5R,6R)-5-hydroxy-6-({4-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2-oxo-2H-chromen-7-yl}oxy)-3-methoxy-2,2-dimethyloxan-4-yl carbamate

C31H36N2O11 (612.2318986)


Novobiocin is only found in individuals that have used or taken this drug. It is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) [PubChem]Novobiocin is an aminocoumarin. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by inhibiting the GyrB subunit of the enzyme involved in energy tranduction. Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB. D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents C254 - Anti-Infective Agent > C258 - Antibiotic CONFIDENCE standard compound; INTERNAL_ID 1168 CONFIDENCE standard compound; INTERNAL_ID 1167 Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity[1][2][3][4][6].

   

3-Amino-4,7-dihydroxy-8-methylcoumarin

3-Amino-4,7-dihydroxy-8-methylcoumarin

C10H9NO4 (207.05315539999998)


A hydroxycoumarin that is 4,7-dihydroxycoumarin bearing additional amino and methyl substituents at positions 3 and 8 respectively.

   

Novobiocin

Novobiocin

C31H36N2O11 (612.2318986)


D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents A coumarin-derived antibiotic obtained from Streptomyces niveus. C254 - Anti-Infective Agent > C258 - Antibiotic Origin: Microbe, Coumarins Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity[1][2][3][4][6].

   

(2r,3r)-3-[2-(2,2-dimethyl-6-methylidenecyclohexyl)ethyl]-2-ethyl-4-hydroxy-7-methoxy-3-methyl-2h-naphtho[1,2-b]furan-6,9-dione

(2r,3r)-3-[2-(2,2-dimethyl-6-methylidenecyclohexyl)ethyl]-2-ethyl-4-hydroxy-7-methoxy-3-methyl-2h-naphtho[1,2-b]furan-6,9-dione

C27H34O5 (438.24061140000003)


   

(7s,9e,11s,12r,13s,14r,15r,16r,17s,18s,19e,21z)-2,15,17,23,27,29-hexahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(e)-[(4-methylpiperazin-1-yl)imino]methyl]-6-oxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1(29),2,4,9,19,21,23,25,27-nonaen-13-yl acetate

(7s,9e,11s,12r,13s,14r,15r,16r,17s,18s,19e,21z)-2,15,17,23,27,29-hexahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(e)-[(4-methylpiperazin-1-yl)imino]methyl]-6-oxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1(29),2,4,9,19,21,23,25,27-nonaen-13-yl acetate

C43H58N4O12 (822.4051028)


   

6-{[(2e)-3,7-dimethylocta-2,6-dien-1-yl]oxy}phenazin-1-ol

6-{[(2e)-3,7-dimethylocta-2,6-dien-1-yl]oxy}phenazin-1-ol

C22H24N2O2 (348.18376839999996)


   

(3z,5z,7z,11z,13z,15z,17z)-20-[(2e)-hex-2-en-1-yl]-7,15-dimethyl-1-azacycloicosa-1,3,5,7,11,13,15,17-octaene-2,9,10-triol

(3z,5z,7z,11z,13z,15z,17z)-20-[(2e)-hex-2-en-1-yl]-7,15-dimethyl-1-azacycloicosa-1,3,5,7,11,13,15,17-octaene-2,9,10-triol

C27H37NO3 (423.27732920000005)