NCBI Taxonomy: 65496
Actinoalloteichus (ncbi_taxid: 65496)
found 15 associated metabolites at genus taxonomy rank level.
Ancestor: Pseudonocardiaceae
Child Taxonomies: environmental samples, Actinoalloteichus fjordicus, Actinoalloteichus caeruleus, Actinoalloteichus spitiensis, Actinoalloteichus hoggarensis, Actinoalloteichus alkalophilus, unclassified Actinoalloteichus, Actinoalloteichus nanshanensis, Actinoalloteichus hymeniacidonis
Novobiocin
Novobiocin is only found in individuals that have used or taken this drug. It is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) [PubChem]Novobiocin is an aminocoumarin. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by inhibiting the GyrB subunit of the enzyme involved in energy tranduction. Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB. D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents C254 - Anti-Infective Agent > C258 - Antibiotic CONFIDENCE standard compound; INTERNAL_ID 1168 CONFIDENCE standard compound; INTERNAL_ID 1167 Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity[1][2][3][4][6].
Novobiocin
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents A coumarin-derived antibiotic obtained from Streptomyces niveus. C254 - Anti-Infective Agent > C258 - Antibiotic Origin: Microbe, Coumarins Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity[1][2][3][4][6].
(2r,3r)-3-[2-(2,2-dimethyl-6-methylidenecyclohexyl)ethyl]-2-ethyl-4-hydroxy-7-methoxy-3-methyl-2h-naphtho[1,2-b]furan-6,9-dione
2-(1,5-dihydroxypent-2-en-2-yl)-3-(hydroxymethyl)cyclopent-2-en-1-one
5-methyl-9-(3-methylbut-2-en-1-yl)-7-oxophenazine-1-carboxylic acid
(7s,9e,11s,12r,13s,14r,15r,16r,17s,18s,19e,21z)-2,15,17,23,27,29-hexahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(e)-[(4-methylpiperazin-1-yl)imino]methyl]-6-oxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1(29),2,4,9,19,21,23,25,27-nonaen-13-yl acetate
(1r,9r,13r)-13-hydroxy-8,10-dioxatricyclo[7.4.0.0²,⁶]tridec-2(6)-en-3-one
(2s,3r,4r,5r,6s)-2-({6-[(z)-(hydroxyimino)methyl]-[2,2'-bipyridin]-3-yl}oxy)-6-methyloxane-3,4,5-triol
(2r,3r,4s,5s,6r)-2-({6-[(z)-(hydroxyimino)methyl]-[2,2'-bipyridin]-4-yl}oxy)-6-methyloxane-3,4,5-triol
n9-[(6s,9r,10s,13s,18as)-11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-n1-[(6s,9r,10s,13s,18as)-13-[(2s)-butan-2-yl]-11-hydroxy-6-isopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid
6-{[(2e)-3,7-dimethylocta-2,6-dien-1-yl]oxy}phenazin-1-ol
C22H24N2O2 (348.18376839999996)
(3s,6s)-3-methyl-6-(2-methylpropyl)-3,6-dihydropyrazine-2,5-diol
C9H16N2O2 (184.12117160000003)
(3z,5z,7z,11z,13z,15z,17z)-20-[(2e)-hex-2-en-1-yl]-7,15-dimethyl-1-azacycloicosa-1,3,5,7,11,13,15,17-octaene-2,9,10-triol
C27H37NO3 (423.27732920000005)