Betulin (BioDeep_00000403518)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

NCGC00168803-04_C30H50O2_Lup-20(29)-ene-3,28-diol, (3beta)-

化学式: C30H50O2 (442.38106)
中文名称: 桦木脑
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 1.7%

分子结构信息

SMILES: C=C(C)[C@@H]1CC[C@]2(CO)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H]
InChI: InChI=1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1

描述信息

Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.

同义名列表

29 个代谢物同义名

(3.beta.)-Lup-20(29)-ene-3,28-diol; Lup-20(29)-ene-3,28-diol, (3beta)-; Lup-20(30)-ene-3beta,28-diol; Lup-20(29)-ene-3beta,28-diol; Prestwick3_000990; betulinic alcohol; EINECS 207-475-5; BPBio1_001165; BSPBio_001059; MEGxp0_001726; ACon1_000091; ZINC03978650; AIDS-002710; B9757_SIGMA; 18211-63-7; Messagenin; AIDS002710; ST5411404; betulinol; NSC692218; AI3-62999; betuline; NSC 4644; 473-98-3; Betulin; Trochol; C08631; C08618; NCGC00168803-04_C30H50O2_Lup-20(29)-ene-3,28-diol, (3beta)-

数据库引用编号

32 个数据库交叉引用编号

ChEBI: CHEBI:3086
KEGG: C08618
PubChem: 72326
ChEMBL: CHEMBL23236
CAS: 7372-31-8
CAS: 473-98-3
MoNA: VF-NPL-QTOF006872
MoNA: VF-NPL-QTOF006871
MoNA: VF-NPL-QTOF006870
MoNA: VF-NPL-QEHF003852
MoNA: VF-NPL-QEHF003851
MoNA: VF-NPL-QEHF003850
MoNA: VF-NPL-QEHF003849
MoNA: VF-NPL-QEHF003848
MoNA: VF-NPL-QEHF003847
MoNA: VF-NPL-QEHF003846
MoNA: VF-NPL-QEHF003845
MoNA: VF-NPL-QEHF003844
MoNA: VF-NPL-QEHF003843
MoNA: VF-NPL-QEHF003842
MoNA: VF-NPL-QEHF003841
MoNA: VF-NPL-QEHF003840
MoNA: VF-NPL-QEHF003839
MoNA: VF-NPL-QEHF003838
MoNA: CCMSLIB00000853400
MoNA: CCMSLIB00000853397
PubChem: 10811
LipidMAPS: LMPR0106140005
KNApSAcK: C00003740
3DMET: B02272
NIKKAJI: J5.959E
medchemexpress: HY-N0083

分类词条

萜类

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

513 个相关的物种来源信息

33090 西河柳: -
33090 胡芦巴: -
33090 牡丹皮: -
33090 苦丁茶: -
33090 酸枣仁: -
33090 连钱草: -
33090 板蓝根: -
33090 零陵香: -
33090 鬼箭羽: -
33090 枳椇子: -
33090 川槿皮: -
33090 千金子: -
33090 北沙参: -
33090 桔梗: -
33090 木香: -
33090 槐花: -
33090 大枣: -
33090 木通: -
33090 杜仲: -
1134458 Avicennia officinalis: 10.1016/S0031-9422(00)82541-8
126913 Suaeda maritima: 10.1016/S0031-9422(00)82541-8
185716 Derris trifoliata: 10.1016/S0031-9422(00)82541-8
61149 Rhizophora mucronata: 10.1016/S0031-9422(00)82541-8
39984 Bruguiera gymnorhiza: 10.1016/S0031-9422(00)82541-8
172013 Ceriops decandra:
328098 Acanthus ilicifolius: 10.1016/S0031-9422(00)82541-8
1142948 Dracaena cinnabari: 10.1016/0031-9422(94)00743-D
198766 Garcinia xanthochymus: 10.1055/S-2008-1075273
77588 Oryza coarctata: 10.1016/0031-9422(88)83098-X
429709 Tabebuia rosea: 10.21608/BFSA.1987.74392
263974 Bacopa monnieri: 10.1007/S10600-007-0133-Y
60117 Cornus capitata: 10.1021/NP50046A034
53873 Dipteryx odorata: 10.1021/JF00111A051
668807 Centaurea horrida: 10.1016/S0305-1978(02)00055-8
496644 Oedera calycina: 10.1016/0031-9422(90)80181-F
714518 Ziziphus jujuba var. spinosa: 10.1111/J.1744-7909.2005.00060.X
326968 Ziziphus jujuba:
1826188 Rosa taiwanensis: 10.1002/JCCS.199500076
1367312 Diospyros nigra: 10.1002/CHIN.200307143
510735 Crataegus pinnatifida: 10.4324/9780203304310_CHAPTER_3
199751 Bupleurum salicifolium:
210348 Brucea javanica: 10.1002/JCCS.200500117
662902 Isodon adenanthus: 10.4268/CJCMM20111611
570484 Diospyros ebenum:
1284885 Cassinia uncata: 10.1016/0031-9422(88)83027-9
1284890 Ozothamnus adnatus: 10.1016/0031-9422(89)80048-2
1284900 Ozothamnus retusus: 10.1016/0031-9422(89)80048-2
1924228 Terminalia glabrescens: 10.1590/S0103-50532003000300021
61143 Ceriops tagal:
1091647 Euphorbia sulcata:
1091639 Euphorbia oxyphylla: 10.1016/S0031-9422(00)82286-4
1091645 Euphorbia retusa:
58228 Garcinia mangostana: 10.1016/0031-9422(91)84157-N
756629 Euphorbia paralias:
556514 Lespedeza bicolor: 10.1016/J.FITOTE.2003.07.012
289753 Rhus chinensis: 10.1055/S-2007-967113
1504171 Doliocarpus dentatus: 10.1002/(SICI)1099-1573(199602)10:1<1::AID-PTR757>3.0.CO;2-A
40340 Pellia epiphylla: 10.1016/S0031-9422(97)00414-7
37690 Citrus trifoliata: 10.1248/CPB.58.971
2704500 Psorospermum tenuifolium: 10.1016/S0031-9422(00)83889-3
2830726 Maerua oblongifolia: 10.1016/S0031-9422(98)00771-7
4202 Sambucus nigra: 10.1002/CBER.19650980115
1948899 Diospyros melanoxylon:
210383 Paliurus hemsleyanus: 10.1016/S0031-9422(97)00313-0
497234 Hedyotis lawsoniae: 10.1248/CPB.32.3906
36622 Chaenomeles sinensis: 10.1248/CPB.51.1318
796159 Sidera lenis: 10.1055/S-0028-1097438
1272984 Moquilea pyrifolia: 10.1021/NP960134J
39350 Ocimum basilicum: 10.1016/B978-0-12-818162-1.00040-7
1009467 Diospyros eriantha:
85246 Plumeria obtusa: 10.1016/J.PHYTOCHEM.2004.04.024
216986 Betula schmidtii: 10.1248/CPB.46.1051
670368 Salacia cordata: 10.1021/NP50081A020
58305 Ilex macropoda:
381101 Senegalia mellifera: 10.1016/J.PHYTOCHEM.2004.03.002
78630 Betula platyphylla:
216994 Betula lenta: 10.1515/HFSG.1991.45.4.265
1009589 Salacia chinensis: 10.1016/J.TET.2008.05.054
63479 Nerium oleander:
39367 Salvia rosmarinus:
662907 Isodon eriocalyx:
1333928 Euphorbia micractina: 10.1021/NP900305J
216992 Betula ermanii:
1312768 Alphitonia whitei: 10.1071/CH9620314
3341 Pinus wallichiana: 10.1002/JCCS.200900089
1603837 Strobilanthes dimorphotricha: 10.1055/S-2005-873125
2508702 Torenia anagallis: 10.1016/J.PHYTOCHEM.2009.12.016
1367309 Diospyros leucomelas:
55363 Diospyros lotus:
1317787 Diospyros gracilescens:
413745 Diospyros fragrans:
413754 Diospyros maingayi:
2708808 Diospyros kamerunensis:
1237540 Diospyros verrucosa:
268846 Diospyros sumatrana:
413755 Diospyros malabarica: 10.1016/S0031-9422(97)01020-0
2708805 Diospyros cinnabarina:
413735 Diospyros curranii: 10.1016/S0031-9422(97)01020-0
413723 Diospyros bipindensis: 10.1016/S0031-9422(97)01020-0
1317788 Diospyros hoyleana:
570487 Diospyros iturensis:
983402 Diospyros argentea:
2708802 Diospyros chevalieri:
413749 Diospyros guianensis: 10.1016/S0031-9422(97)01020-0
1317786 Diospyros gabunensis:
570493 Diospyros sanza-minika:
570490 Diospyros monbuttensis:
2945307 Diospyros walkeri: 10.1016/S0031-9422(97)01020-0
268838 Diospyros discolor:
1932074 Diospyros blancoi:
240001 Diospyros ferrea: 10.1016/S0031-9422(97)01020-0
2945278 Diospyros canaliculata:
413758 Diospyros maritima:
589132 Diospyros wallichii:
413718 Diospyros abyssinica:
413760 Diospyros mespiliformis:
413757 Diospyros mannii:
2945281 Diospyros elliptifolia:
570480 Diospyros crassiflora:
1008904 Diospyros morrisiana: 10.1016/S0031-9422(97)01020-0
413728 Diospyros cauliflora: 10.1016/S0031-9422(97)01020-0
2945305 Diospyros thwaitesii: 10.1016/S0031-9422(97)01020-0
1938276 Diospyros siderophylla: 10.1016/S0031-9422(97)01020-0
13493 Diospyros virginiana:
570498 Diospyros zenkeri:
570481 Diospyros dendo:
413732 Diospyros consolatae: 10.1016/S0031-9422(97)01020-0
2945273 Diospyros albiflora: 10.1016/S0031-9422(97)01020-0
413727 Diospyros castanea: 10.1016/S0031-9422(97)01020-0
1317789 Diospyros obliquifolia: 10.1016/S0031-9422(97)01020-0
413762 Diospyros montana: 10.1016/S0031-9422(97)01020-0
589111 Diospyros buxifolia: 10.1016/S0031-9422(97)01020-0
2945279 Diospyros candolleana: 10.1016/S0031-9422(97)01020-0
35925 Diospyros kaki: 10.1016/S0031-9422(97)01020-0
262529 Prunus pensylvanica: 10.1016/0378-8741(84)90002-3
3326 Larix laricina: 10.1016/0378-8741(84)90002-3
669713 Juniperus horizontalis: 10.1016/0378-8741(84)90002-3
66173 Tsuga canadensis: 10.1016/0378-8741(84)90002-3
193310 Sorbus americana: 10.1016/0378-8741(84)90002-3
185559 Ilex verticillata: 10.1016/0378-8741(84)90002-3
3507 Betula papyrifera:
38872 Fraxinus americana: 10.1016/0378-8741(84)90002-3
90345 Abies balsamea: 10.1016/0378-8741(84)90002-3
3510 Morella cerifera: 10.1016/0378-8741(84)90002-3
29742 Comptonia peregrina: 10.1016/0378-8741(84)90002-3
58039 Juniperus communis: 10.1016/0378-8741(84)90002-3
3335 Picea mariana: 10.1016/0378-8741(84)90002-3
255348 Rhus typhina: 10.1016/0378-8741(84)90002-3
1609897 Syzygium formosanum: 10.1021/NP980313W
13427 Cichorium intybus: 10.1021/NP800001V
310427 Jasminum lanceolarium: 10.1248/CPB.55.474
413790 Euclea divinorum: 10.1016/S0031-9422(97)00398-1
54460 Mundulea sericea: 10.1016/S0031-9422(00)89097-4
1353471 Dalbergia sericea: 10.1016/S0031-9422(00)89097-4
340447 Vatica diospyroides: 10.1021/JO9902087
85202 Euclea natalensis: 10.1021/NP030465D
1284855 Ozothamnus argophyllus: 10.1016/S0040-4039(01)89626-X
1442666 Helichrysum herbaceum: 10.1016/S0040-4039(01)89626-X
765745 Sorbus decora: 10.1021/NP1003005
295139 Leptospermum scoparium:
880079 Rhododendron dauricum: 10.1007/BF00564187
2803927 Hypoestes purpurea: 10.1021/NP0497402
109069 Alnus rubra: 10.3109/13880209509088144
496609 Cyclolepis genistoides: 10.1016/S0031-9422(97)00021-6
73757 Melaleuca ericifolia: 10.1021/NP800360A
493990 Grewia bicolor: 10.1016/0378-8741(86)90109-1
98583 Rhodomyrtus tomentosa: 10.1016/0031-9422(75)83058-5
212941 Euphorbia myrsinites: 10.1016/0031-9422(94)00806-5
2039553 Salvia xalapensis:
386244 Trichosanthes ovigera: 10.1016/S0031-9422(97)00433-0
387127 Coccinia grandis: 10.1016/S0031-9422(97)00433-0
685054 Trichosanthes cucumeroides: 10.1016/S0031-9422(97)00433-0
320667 Trichosanthes dioica: 10.1016/S0031-9422(97)00433-0
211500 Betula maximowicziana:
213552 Celtis philippensis: 10.1016/S0031-9422(02)00520-4
199133 Bupleurum fruticescens: 10.1080/10575639708048311
489987 Gymnosporia cassinoides:
2822244 Maytenus canariensis:
2029442 Vatica harmandiana: 10.1021/NP020379Y
2896614 Tricholepis glaberrima: 10.1055/S-0028-1097711
290962 Hippobromus pauciflorus: 10.1016/0031-9422(83)83027-1
693381 Pittosporum pentandrum: 10.1016/S0031-9422(96)00852-7
1492770 Euphorbia trigona: 10.1016/S0031-9422(00)81079-1
2321275 Coussarea paniculata: 10.1021/NP0204848
183267 Talipariti tiliaceum: 10.1002/HLCA.200890088
490002 Maytenus boaria:
1825850 Monteverdia truncata:
1081520 Monteverdia ilicifolia:
1071199 Pterocarpus santalinus: 10.1016/S0031-9422(00)97131-0
39331 Lavandula latifolia: 10.1016/0031-9422(92)80309-3
316645 Mallotus philippensis: 10.1055/S-2008-1034347
13523 Euptelea polyandra: 10.1021/NP50054A031
1075355 Camchaya loloana: 10.1002/HLCA.201000138
66629 Fagonia indica: 10.1016/S0031-9422(98)00750-X
1225085 Salacia beddomei: 10.1016/0031-9422(95)00943-4
458695 Ligustrum lucidum: 10.4268/CJCMM20100712
46072 Ligustrum japonicum: 10.4268/CJCMM20100712
284673 Betula alnoides:
4270 Byrsonima crassifolia: 10.3109/13880209509088143
46391 Cussonia spicata: 10.1016/S0305-1978(98)00070-2
260589 Bystropogon canariensis: 10.1016/S0305-1978(98)00070-2
51240 Juglans regia: 10.1007/978-1-4615-4913-0_23
268843 Diospyros rhodocalyx: 10.1055/S-2006-958085
23211 Pyrus communis:
1266558 Origanum compactum: 10.1055/S-2006-962358
119949 Myrtus communis: 10.1002/EJOC.200500936
392697 Salvia thymoides: 10.1016/S0031-9422(97)80021-0
880084 Rhododendron sichotense: 10.1007/BF00564024
947117 Valeriana laxiflora: 10.1055/S-2004-827149
306377 Clinopodium acinos: 10.1007/BF00563844
672819 Glechoma hirsuta: 10.1007/BF00563844
3490 Artocarpus integer: 10.1016/S0031-9422(00)90605-8
3489 Artocarpus heterophyllus: 10.1016/S0031-9422(00)90605-8
141189 Woodfordia fruticosa: 10.1055/S-0028-1097262
53205 Ilex latifolia: 10.3329/DUJPS.V3I1.189
260601 Hyssopus seravschanicus: 10.1007/BF00570696
110284 Eleocharis dulcis: 10.1021/JF00043A032
138030 Senegalia modesta: 10.1055/S-0028-1097801
751877 Zataria multiflora: 10.1016/S0031-9422(00)90054-2
1704625 Croton megalocarpus: 10.1016/S0031-9422(00)98083-X
29760 Vitis vinifera: 10.21608/BFSA.2001.65958
93772 Guazuma ulmifolia: 10.1055/S-0028-1097596
479633 Anisacanthus quadrifidus: 10.1076/PHBI.40.2.96.5848
84005 Arbutus unedo: 10.1080/14786410500161205
2726338 Coccoloba acrostichoides: 10.1016/J.FITOTE.2003.08.003
387928 Anemone raddeana: 10.4268/CJCMM20112416
880082 Rhododendron ledebourii: 10.1007/BF01032020
58331 Quercus suber: 10.1016/S0926-6690(01)00091-7
197961 Scaevola floribunda: 10.1021/NP9702852
1279044 Melilotus messanensis: 10.1016/S0031-9422(00)89726-5
346999 Senna siamea: 10.1016/S0031-9422(00)81245-5
384959 Euclea crispa: 10.1016/S0031-9422(02)00619-2
1801587 Byrsonima microphylla: 10.1016/J.PHYTOCHEM.2005.07.011
1582456 Chuquiraga atacamensis: 10.4067/S0366-16442000000100007
356590 Pyrus pyraster: 10.1080/1478641031000149821
2720245 Pyrus bourgaeana: 10.1080/1478641031000149821
1081525 Monteverdia rigida: 10.1016/J.CBI.2009.12.012
3505 Betula pendula: 10.1007/BF00629882
38787 Betula pubescens: 10.1007/BF00629882
582711 Alyxia sinensis: 10.7324/JAPS.2015.50912
1603691 Alyxia levinei: 10.7324/JAPS.2015.50912
99438 Lumnitzera racemosa: 10.3998/ARK.5550190.0004.304
205524 Solanum aethiopicum: 10.1055/S-0028-1097933
216993 Betula fruticosa: 10.1248/CPB.46.169
361422 Betula ovalifolia: 10.1248/CPB.46.169
1340885 Symplocos racemosa: 10.1016/0031-9422(90)85284-M
279243 Caraipa densifolia: 10.1021/NP50025A012
2054469 Dracocephalum forrestii: 10.1002/HLCA.200690271
714108 Ancistrocladus tectorius: 10.1016/S0031-9422(96)00510-9
714096 Ancistrocladus cochinchinensis: 10.1016/S0031-9422(96)00510-9
507529 Hygrophila schulli:
2030897 Hygrophila auriculata:
52822 Alstonia scholaris: 10.21608/BFSA.2000.66312
1233953 Betula cordifolia: 10.1016/0031-9422(88)80120-1
216989 Betula populifolia: 10.1016/0031-9422(88)80120-1
4359 Sarracenia flava: 10.1016/S0031-9422(00)86845-4
149685 Bowdichia virgilioides: 10.1016/S0367-326X(99)00129-X
123438 Orthosphenia mexicana: 10.1021/NP50043A021
2571305 Arnebia hispidissima: 10.1076/PHBI.41.4.231.15667
106660 Ampelozizyphus amazonicus: 10.1016/0031-9422(91)83076-W
756620 Euphorbia heteradena: 10.1016/J.BSE.2019.04.006
296044 Phyllanthus flexuosus:
282640 Microcybe multiflora: 10.1016/0305-1978(93)90064-X
1079077 Pterodon emarginatus: 10.1590/S0103-50531998000300014
1134458 Avicennia officinalis: 10.1016/S0031-9422(00)82541-8
126913 Suaeda maritima: 10.1016/S0031-9422(00)82541-8
185716 Derris trifoliata: 10.1016/S0031-9422(00)82541-8
61149 Rhizophora mucronata: 10.1016/S0031-9422(00)82541-8
39984 Bruguiera gymnorhiza: 10.1016/S0031-9422(00)82541-8
172013 Ceriops decandra:
328098 Acanthus ilicifolius: 10.1016/S0031-9422(00)82541-8
1142948 Dracaena cinnabari: 10.1016/0031-9422(94)00743-D
198766 Garcinia xanthochymus: 10.1055/S-2008-1075273
77588 Oryza coarctata: 10.1016/0031-9422(88)83098-X
429709 Tabebuia rosea: 10.21608/BFSA.1987.74392
263974 Bacopa monnieri: 10.1007/S10600-007-0133-Y
60117 Cornus capitata: 10.1021/NP50046A034
53873 Dipteryx odorata: 10.1021/JF00111A051
668807 Centaurea horrida: 10.1016/S0305-1978(02)00055-8
496644 Oedera calycina: 10.1016/0031-9422(90)80181-F
714518 Ziziphus jujuba var. spinosa: 10.1111/J.1744-7909.2005.00060.X
326968 Ziziphus jujuba:
1826188 Rosa taiwanensis: 10.1002/JCCS.199500076
1367312 Diospyros nigra: 10.1002/CHIN.200307143
510735 Crataegus pinnatifida: 10.4324/9780203304310_CHAPTER_3
199751 Bupleurum salicifolium:
210348 Brucea javanica: 10.1002/JCCS.200500117
662902 Isodon adenanthus: 10.4268/CJCMM20111611
570484 Diospyros ebenum:
1284885 Cassinia uncata: 10.1016/0031-9422(88)83027-9
1284890 Ozothamnus adnatus: 10.1016/0031-9422(89)80048-2
1284900 Ozothamnus retusus: 10.1016/0031-9422(89)80048-2
1924228 Terminalia glabrescens: 10.1590/S0103-50532003000300021
61143 Ceriops tagal:
1091647 Euphorbia sulcata:
1091639 Euphorbia oxyphylla: 10.1016/S0031-9422(00)82286-4
1091645 Euphorbia retusa:
58228 Garcinia mangostana: 10.1016/0031-9422(91)84157-N
756629 Euphorbia paralias:
556514 Lespedeza bicolor: 10.1016/J.FITOTE.2003.07.012
289753 Rhus chinensis: 10.1055/S-2007-967113
1504171 Doliocarpus dentatus: 10.1002/(SICI)1099-1573(199602)10:1<1::AID-PTR757>3.0.CO;2-A
40340 Pellia epiphylla: 10.1016/S0031-9422(97)00414-7
37690 Citrus trifoliata: 10.1248/CPB.58.971
2704500 Psorospermum tenuifolium: 10.1016/S0031-9422(00)83889-3
2830726 Maerua oblongifolia: 10.1016/S0031-9422(98)00771-7
4202 Sambucus nigra: 10.1002/CBER.19650980115
1948899 Diospyros melanoxylon:
210383 Paliurus hemsleyanus: 10.1016/S0031-9422(97)00313-0
497234 Hedyotis lawsoniae: 10.1248/CPB.32.3906
36622 Chaenomeles sinensis: 10.1248/CPB.51.1318
796159 Sidera lenis: 10.1055/S-0028-1097438
1272984 Moquilea pyrifolia: 10.1021/NP960134J
39350 Ocimum basilicum: 10.1016/B978-0-12-818162-1.00040-7
1009467 Diospyros eriantha:
85246 Plumeria obtusa: 10.1016/J.PHYTOCHEM.2004.04.024
216986 Betula schmidtii: 10.1248/CPB.46.1051
670368 Salacia cordata: 10.1021/NP50081A020
58305 Ilex macropoda:
381101 Senegalia mellifera: 10.1016/J.PHYTOCHEM.2004.03.002
78630 Betula platyphylla:
216994 Betula lenta: 10.1515/HFSG.1991.45.4.265
1009589 Salacia chinensis: 10.1016/J.TET.2008.05.054
63479 Nerium oleander:
39367 Salvia rosmarinus:
662907 Isodon eriocalyx:
1333928 Euphorbia micractina: 10.1021/NP900305J
216992 Betula ermanii:
1312768 Alphitonia whitei: 10.1071/CH9620314
3341 Pinus wallichiana: 10.1002/JCCS.200900089
1603837 Strobilanthes dimorphotricha: 10.1055/S-2005-873125
2508702 Torenia anagallis: 10.1016/J.PHYTOCHEM.2009.12.016
1367309 Diospyros leucomelas:
55363 Diospyros lotus:
1317787 Diospyros gracilescens:
413745 Diospyros fragrans:
413754 Diospyros maingayi:
2708808 Diospyros kamerunensis:
1237540 Diospyros verrucosa:
268846 Diospyros sumatrana:
413755 Diospyros malabarica: 10.1016/S0031-9422(97)01020-0
2708805 Diospyros cinnabarina:
413735 Diospyros curranii: 10.1016/S0031-9422(97)01020-0
413723 Diospyros bipindensis: 10.1016/S0031-9422(97)01020-0
1317788 Diospyros hoyleana:
570487 Diospyros iturensis:
983402 Diospyros argentea:
2708802 Diospyros chevalieri:
413749 Diospyros guianensis: 10.1016/S0031-9422(97)01020-0
1317786 Diospyros gabunensis:
570493 Diospyros sanza-minika:
570490 Diospyros monbuttensis:
2945307 Diospyros walkeri: 10.1016/S0031-9422(97)01020-0
268838 Diospyros discolor:
1932074 Diospyros blancoi:
240001 Diospyros ferrea: 10.1016/S0031-9422(97)01020-0
2945278 Diospyros canaliculata:
413758 Diospyros maritima:
589132 Diospyros wallichii:
413718 Diospyros abyssinica:
413760 Diospyros mespiliformis:
413757 Diospyros mannii:
2945281 Diospyros elliptifolia:
570480 Diospyros crassiflora:
1008904 Diospyros morrisiana: 10.1016/S0031-9422(97)01020-0
413728 Diospyros cauliflora: 10.1016/S0031-9422(97)01020-0
2945305 Diospyros thwaitesii: 10.1016/S0031-9422(97)01020-0
1938276 Diospyros siderophylla: 10.1016/S0031-9422(97)01020-0
13493 Diospyros virginiana:
570498 Diospyros zenkeri:
570481 Diospyros dendo:
413732 Diospyros consolatae: 10.1016/S0031-9422(97)01020-0
2945273 Diospyros albiflora: 10.1016/S0031-9422(97)01020-0
413727 Diospyros castanea: 10.1016/S0031-9422(97)01020-0
1317789 Diospyros obliquifolia: 10.1016/S0031-9422(97)01020-0
413762 Diospyros montana: 10.1016/S0031-9422(97)01020-0
589111 Diospyros buxifolia: 10.1016/S0031-9422(97)01020-0
2945279 Diospyros candolleana: 10.1016/S0031-9422(97)01020-0
35925 Diospyros kaki: 10.1016/S0031-9422(97)01020-0
262529 Prunus pensylvanica: 10.1016/0378-8741(84)90002-3
3326 Larix laricina: 10.1016/0378-8741(84)90002-3
669713 Juniperus horizontalis: 10.1016/0378-8741(84)90002-3
66173 Tsuga canadensis: 10.1016/0378-8741(84)90002-3
193310 Sorbus americana: 10.1016/0378-8741(84)90002-3
185559 Ilex verticillata: 10.1016/0378-8741(84)90002-3
3507 Betula papyrifera:
38872 Fraxinus americana: 10.1016/0378-8741(84)90002-3
90345 Abies balsamea: 10.1016/0378-8741(84)90002-3
3510 Morella cerifera: 10.1016/0378-8741(84)90002-3
29742 Comptonia peregrina: 10.1016/0378-8741(84)90002-3
58039 Juniperus communis: 10.1016/0378-8741(84)90002-3
3335 Picea mariana: 10.1016/0378-8741(84)90002-3
255348 Rhus typhina: 10.1016/0378-8741(84)90002-3
1609897 Syzygium formosanum: 10.1021/NP980313W
13427 Cichorium intybus: 10.1021/NP800001V
310427 Jasminum lanceolarium: 10.1248/CPB.55.474
413790 Euclea divinorum: 10.1016/S0031-9422(97)00398-1
54460 Mundulea sericea: 10.1016/S0031-9422(00)89097-4
1353471 Dalbergia sericea: 10.1016/S0031-9422(00)89097-4
340447 Vatica diospyroides: 10.1021/JO9902087
85202 Euclea natalensis: 10.1021/NP030465D
1284855 Ozothamnus argophyllus: 10.1016/S0040-4039(01)89626-X
1442666 Helichrysum herbaceum: 10.1016/S0040-4039(01)89626-X
765745 Sorbus decora: 10.1021/NP1003005
295139 Leptospermum scoparium:
880079 Rhododendron dauricum: 10.1007/BF00564187
2803927 Hypoestes purpurea: 10.1021/NP0497402
109069 Alnus rubra: 10.3109/13880209509088144
496609 Cyclolepis genistoides: 10.1016/S0031-9422(97)00021-6
73757 Melaleuca ericifolia: 10.1021/NP800360A
493990 Grewia bicolor: 10.1016/0378-8741(86)90109-1
98583 Rhodomyrtus tomentosa: 10.1016/0031-9422(75)83058-5
212941 Euphorbia myrsinites: 10.1016/0031-9422(94)00806-5
2039553 Salvia xalapensis:
386244 Trichosanthes ovigera: 10.1016/S0031-9422(97)00433-0
387127 Coccinia grandis: 10.1016/S0031-9422(97)00433-0
685054 Trichosanthes cucumeroides: 10.1016/S0031-9422(97)00433-0
320667 Trichosanthes dioica: 10.1016/S0031-9422(97)00433-0
211500 Betula maximowicziana:
213552 Celtis philippensis: 10.1016/S0031-9422(02)00520-4
199133 Bupleurum fruticescens: 10.1080/10575639708048311
489987 Gymnosporia cassinoides:
2822244 Maytenus canariensis:
2029442 Vatica harmandiana: 10.1021/NP020379Y
2896614 Tricholepis glaberrima: 10.1055/S-0028-1097711
290962 Hippobromus pauciflorus: 10.1016/0031-9422(83)83027-1
693381 Pittosporum pentandrum: 10.1016/S0031-9422(96)00852-7
1492770 Euphorbia trigona: 10.1016/S0031-9422(00)81079-1
2321275 Coussarea paniculata: 10.1021/NP0204848
183267 Talipariti tiliaceum: 10.1002/HLCA.200890088
490002 Maytenus boaria:
1825850 Monteverdia truncata:
1081520 Monteverdia ilicifolia:
1071199 Pterocarpus santalinus: 10.1016/S0031-9422(00)97131-0
39331 Lavandula latifolia: 10.1016/0031-9422(92)80309-3
316645 Mallotus philippensis: 10.1055/S-2008-1034347
13523 Euptelea polyandra: 10.1021/NP50054A031
1075355 Camchaya loloana: 10.1002/HLCA.201000138
66629 Fagonia indica: 10.1016/S0031-9422(98)00750-X
1225085 Salacia beddomei: 10.1016/0031-9422(95)00943-4
458695 Ligustrum lucidum: 10.4268/CJCMM20100712
46072 Ligustrum japonicum: 10.4268/CJCMM20100712
284673 Betula alnoides:
4270 Byrsonima crassifolia: 10.3109/13880209509088143
46391 Cussonia spicata: 10.1016/S0305-1978(98)00070-2
260589 Bystropogon canariensis: 10.1016/S0305-1978(98)00070-2
51240 Juglans regia: 10.1007/978-1-4615-4913-0_23
268843 Diospyros rhodocalyx: 10.1055/S-2006-958085
23211 Pyrus communis:
1266558 Origanum compactum: 10.1055/S-2006-962358
119949 Myrtus communis: 10.1002/EJOC.200500936
392697 Salvia thymoides: 10.1016/S0031-9422(97)80021-0
880084 Rhododendron sichotense: 10.1007/BF00564024
947117 Valeriana laxiflora: 10.1055/S-2004-827149
306377 Clinopodium acinos: 10.1007/BF00563844
672819 Glechoma hirsuta: 10.1007/BF00563844
3490 Artocarpus integer: 10.1016/S0031-9422(00)90605-8
3489 Artocarpus heterophyllus: 10.1016/S0031-9422(00)90605-8
141189 Woodfordia fruticosa: 10.1055/S-0028-1097262
53205 Ilex latifolia: 10.3329/DUJPS.V3I1.189
260601 Hyssopus seravschanicus: 10.1007/BF00570696
110284 Eleocharis dulcis: 10.1021/JF00043A032
138030 Senegalia modesta: 10.1055/S-0028-1097801
751877 Zataria multiflora: 10.1016/S0031-9422(00)90054-2
1704625 Croton megalocarpus: 10.1016/S0031-9422(00)98083-X
29760 Vitis vinifera: 10.21608/BFSA.2001.65958
93772 Guazuma ulmifolia: 10.1055/S-0028-1097596
479633 Anisacanthus quadrifidus: 10.1076/PHBI.40.2.96.5848
84005 Arbutus unedo: 10.1080/14786410500161205
2726338 Coccoloba acrostichoides: 10.1016/J.FITOTE.2003.08.003
387928 Anemone raddeana: 10.4268/CJCMM20112416
880082 Rhododendron ledebourii: 10.1007/BF01032020
58331 Quercus suber: 10.1016/S0926-6690(01)00091-7
197961 Scaevola floribunda: 10.1021/NP9702852
1279044 Melilotus messanensis: 10.1016/S0031-9422(00)89726-5
346999 Senna siamea: 10.1016/S0031-9422(00)81245-5
384959 Euclea crispa: 10.1016/S0031-9422(02)00619-2
1801587 Byrsonima microphylla: 10.1016/J.PHYTOCHEM.2005.07.011
1582456 Chuquiraga atacamensis: 10.4067/S0366-16442000000100007
356590 Pyrus pyraster: 10.1080/1478641031000149821
2720245 Pyrus bourgaeana: 10.1080/1478641031000149821
1081525 Monteverdia rigida: 10.1016/J.CBI.2009.12.012
3505 Betula pendula: 10.1007/BF00629882
38787 Betula pubescens: 10.1007/BF00629882
582711 Alyxia sinensis: 10.7324/JAPS.2015.50912
1603691 Alyxia levinei: 10.7324/JAPS.2015.50912
99438 Lumnitzera racemosa: 10.3998/ARK.5550190.0004.304
205524 Solanum aethiopicum: 10.1055/S-0028-1097933
216993 Betula fruticosa: 10.1248/CPB.46.169
361422 Betula ovalifolia: 10.1248/CPB.46.169
1340885 Symplocos racemosa: 10.1016/0031-9422(90)85284-M
279243 Caraipa densifolia: 10.1021/NP50025A012
2054469 Dracocephalum forrestii: 10.1002/HLCA.200690271
714108 Ancistrocladus tectorius: 10.1016/S0031-9422(96)00510-9
714096 Ancistrocladus cochinchinensis: 10.1016/S0031-9422(96)00510-9
507529 Hygrophila schulli:
2030897 Hygrophila auriculata:
52822 Alstonia scholaris: 10.21608/BFSA.2000.66312
1233953 Betula cordifolia: 10.1016/0031-9422(88)80120-1
216989 Betula populifolia: 10.1016/0031-9422(88)80120-1
4359 Sarracenia flava: 10.1016/S0031-9422(00)86845-4
149685 Bowdichia virgilioides: 10.1016/S0367-326X(99)00129-X
123438 Orthosphenia mexicana: 10.1021/NP50043A021
2571305 Arnebia hispidissima: 10.1076/PHBI.41.4.231.15667
106660 Ampelozizyphus amazonicus: 10.1016/0031-9422(91)83076-W
756620 Euphorbia heteradena: 10.1016/J.BSE.2019.04.006
296044 Phyllanthus flexuosus:
282640 Microcybe multiflora: 10.1016/0305-1978(93)90064-X
1079077 Pterodon emarginatus: 10.1590/S0103-50531998000300014
326968 Ziziphus jujuba Mill.: -
212925 Euphorbia lathyris L.: -
51240 Juglans regia: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Prativa Biswasroy, Deepak Pradhan, Dilip Kumar Pradhan, Goutam Ghosh, Goutam Rath. Development of Betulin-Loaded Nanostructured Lipid Carriers for the Management of Imiquimod-Induced Psoriasis. AAPS PharmSciTech. 2024 Mar; 25(3):57. doi: 10.1208/s12249-024-02774-1. [PMID: 38472545]
Feyisayo O Adepoju, Ksenia V Sokolova, Irina F Gette, Irina G Danilova, Mikhail V Tsurkan, Alicia C Mondragon, Elena G Kovaleva, Jose Manuel Miranda. Protective Effect of Betulin on Streptozotocin-Nicotinamide-Induced Diabetes in Female Rats. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042166. [PMID: 38396842]
Yiding Deng, Ruili Wang, Zhiyuan Ma, Weiwei Zuo, Meifang Zhu. Synthesis and Fabrication of Betulin-Derived Polysulfide and Polysulfoxide Electrospun Fibers for Fruit Preservation. Journal of agricultural and food chemistry. 2023 Dec; 71(48):18857-18864. doi: 10.1021/acs.jafc.3c07117. [PMID: 37994873]
Mengdi Lv, Yue Zheng, Jian Wu, Zhengqi Shen, Binglian Guo, Guojing Hu, Yuanlei Huang, Jingyue Zhao, Yong Qian, Zhi Su, Chao Wu, Xuling Xue, Hong-Ke Liu, Zong-Wan Mao. Evoking Ferroptosis by Synergistic Enhancement of a Cyclopentadienyl Iridium-Betulin Immune Agonist. Angewandte Chemie (International ed. in English). 2023 Oct; ?(?):e202312897. doi: 10.1002/anie.202312897. [PMID: 37830171]
Umesh Chandra Dash, Sandeep Kumar Swain, Atala Bihari Jena, Jagnehswar Dandapat, Atish Kumar Sahoo. The ameliorative effect of Piper trioicum in attenuating cognitive deficit in scopolamine induced neurotoxicity in experimental rats. Journal of ethnopharmacology. 2023 Jul; ?(?):116911. doi: 10.1016/j.jep.2023.116911. [PMID: 37451488]
Kai-Yuan Chen, Wei-Lin Hsu, Shih-Wei Hsu, Chao-Hsuan Chen, Kun-Ting Hong, Chia-Wen Tsai, Wen-Shin Chang, Chao-Chun Chen, Jen-Sheng Pei, Hsu-Tung Lee, DA-Tian Bau. Involvement of Mitochondrial Damage and Oxidative Stress in Apoptosis Induced by Betulin Plus Arsenic Trioxide in Neuroblastoma Cells. Anticancer research. 2023 Jun; 43(6):2467-2476. doi: 10.21873/anticanres.16414. [PMID: 37247918]
Maria Błaszczyk, Agata Kozioł, Anna Palko-Łabuz, Kamila Środa-Pomianek, Olga Wesołowska. Modulators of cellular cholesterol homeostasis as antiproliferative and model membranes perturbing agents. Biochimica et biophysica acta. Biomembranes. 2023 May; 1865(6):184163. doi: 10.1016/j.bbamem.2023.184163. [PMID: 37172710]
Amira E Farage, Walied Abdo, Amira Osman, Mona A Abdel-Kareem, Zaki H Hakami, Ahmad Alsulimani, Albandari Bin-Ammar, Ashwag S Alanazi, Bader Alsuwayt, Mohammed M Alanazi, Samar A Antar, Emadeldin M Kamel, Ayman M Mahmoud. Betulin prevents high fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress and upregulating Nrf2 and SIRT1 in rats. Life sciences. 2023 Apr; ?(?):121688. doi: 10.1016/j.lfs.2023.121688. [PMID: 37030617]
E V Averyanova, M N Shkolnikova, O V Chugunova, O N Mazko. [Effects of triterpenoids in fatty products on liver condition of laboratory animals with acute toxic hepatitis]. Voprosy pitaniia. 2023; 92(4):81-91. doi: 10.33029/0042-8833-2023-92-4-81-91. [PMID: 37801458]
Hellen Karla Oliveira Marques, Maria Gabriela Ferreira Figueiredo, Willian Samuel de Souza Pio, Leonardo Monteiro Ribeiro, Islaine Franciely Pinheiro de Azevedo, Lucienir Pains Duarte, Grasiely Faria de Sousa, Mariana Guerra de Aguilar, Maria Olívia Mercadante-Simões. Laticifer ontogenesis and the chemical constituents of Marsdenia zehntneri (Apocynaceae) latex in a semiarid environment. Planta. 2022 Dec; 257(1):19. doi: 10.1007/s00425-022-04050-7. [PMID: 36538159]
Ting Ouyang, Huafeng Yin, Jianbo Yang, Yue Liu, Shuangcheng Ma. Tissue regeneration effect of betulin via inhibition of ROS/MAPKs/NF-ĸB axis using zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113420. doi: 10.1016/j.biopha.2022.113420. [PMID: 36076542]
Prabhjit Kaur, Saroj Arora, Rajbir Singh. Isolation, characterization and biological activities of betulin from Acacia nilotica bark. Scientific reports. 2022 06; 12(1):9370. doi: 10.1038/s41598-022-13338-3. [PMID: 35672366]
Olga V Demets, Altynaray T Takibayeva, Rymchan Z Kassenov, Madina R Aliyeva. Methods of Betulin Extraction from Birch Bark. Molecules (Basel, Switzerland). 2022 Jun; 27(11):. doi: 10.3390/molecules27113621. [PMID: 35684557]
Wei-Ya Yan, Jian Cai, Jiang-Nan Wang, Yong-Sheng Gong, Xue-Bing Ding. Co-treatment of betulin and gefitinib is effective against EGFR wild-type/KRAS-mutant non-small cell lung cancer by inducing ferroptosis. Neoplasma. 2022 May; 69(3):648-656. doi: 10.4149/neo_2022_211103n1568. [PMID: 35330996]
Mapula Razwinani, Keolebogile Shirley Motaung. The influence of friedelin, resinone, tingenone and betulin of compounds on chondrogenic differentiation of porcine adipose-derived mesenchymal stem cells (pADMSCs). Biochimie. 2022 May; 196(?):234-242. doi: 10.1016/j.biochi.2022.01.018. [PMID: 35121053]
Celina Kruszniewska-Rajs, Barbara Strzałka-Mrozik, Magdalena Kimsa-Dudek, Agnieszka Synowiec-Wojtarowicz, Elwira Chrobak, Ewa Bębenek, Stanisław Boryczka, Stanisław Głuszek, Joanna Magdalena Gola. The Influence of Betulin and Its Derivatives EB5 and ECH147 on the Antioxidant Status of Human Renal Proximal Tubule Epithelial Cells. International journal of molecular sciences. 2022 Feb; 23(5):. doi: 10.3390/ijms23052524. [PMID: 35269667]
Claudia Vater, Leonie Bosch, Alexandra Mitter, Thomas Göls, Saskia Seiser, Elke Heiss, Adelheid Elbe-Bürger, Michael Wirth, Claudia Valenta, Victoria Klang. Lecithin-based nanoemulsions of traditional herbal wound healing agents and their effect on human skin cells. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2022 Jan; 170(?):1-9. doi: 10.1016/j.ejpb.2021.11.004. [PMID: 34798283]
Aleksandra Ostapiuk, Łukasz Kurach, Maciej Strzemski, Jacek Kurzepa, Anna Hordyjewska. Evaluation of Antioxidative Mechanisms In Vitro and Triterpenes Composition of Extracts from Silver Birch (Betula pendula Roth) and Black Birch (Betula obscura Kotula) Barks by FT-IR and HPLC-PDA. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154633. [PMID: 34361786]
Augustine A Ahmadu, Claire Delehouzé, Anas Haruna, Lukman Mustapha, Bilqis A Lawal, Aniefiok Udobre, Blandine Baratte, Camilla Triscornia, Axelle Autret, Thomas Robert, Jeannette Chloë Bulinski, Morgane Rousselot, Mélanie Simoes Eugénio, Marie-Thérèse Dimanche-Boitrel, Jacobus P Petzer, Lesetja J Legoabe, Stéphane Bach. Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154599. [PMID: 34361750]
Ramona Daniela Pârvănescu Pană, Claudia-Geanina Watz, Elena-Alina Moacă, Lavinia Vlaia, Iasmina Marcovici, Ioana Gabriela Macașoi, Florin Borcan, Ioana Olariu, Georgeta Coneac, George-Andrei Drăghici, Zorin Crăiniceanu, Daniela Flondor Ionescu, Alexandra Enache, Cristina Adriana Dehelean. Oleogel Formulations for the Topical Delivery of Betulin and Lupeol in Skin Injuries-Preparation, Physicochemical Characterization, and Pharmaco-Toxicological Evaluation. Molecules (Basel, Switzerland). 2021 Jul; 26(14):. doi: 10.3390/molecules26144174. [PMID: 34299450]
Jinku Zhang, Bingjuan Zhou, Jirui Sun, Hong Chen, Zhao Yang. Betulin ameliorates 7,12-dimethylbenz(a)anthracene-induced rat mammary cancer by modulating MAPK and AhR/Nrf-2 signaling pathway. Journal of biochemical and molecular toxicology. 2021 Jul; 35(7):e22779. doi: 10.1002/jbt.22779. [PMID: 33759307]
Yoganathan Kamaraj, Sangeetha Dhayalan, Uma Chinnaiyan, Veenayohini Kumaresan, Satheeshkumar Subramaniyan, Deepak Kumar, Kokila Muniyandi, Ganesh Punamalai. Triterpenoid compound betulin attenuates allergic airway inflammation by modulating antioxidants, inflammatory cytokines and tissue transglutaminase in ovalbumin-induced asthma mice model. The Journal of pharmacy and pharmacology. 2021 Jun; 73(7):968-978. doi: 10.1093/jpp/rgab015. [PMID: 33769499]
Andrzej Günther, Edyta Makuch, Anna Nowak, Wiktoria Duchnik, Łukasz Kucharski, Robert Pełech, Adam Klimowicz. Enhancement of the Antioxidant and Skin Permeation Properties of Betulin and Its Derivatives. Molecules (Basel, Switzerland). 2021 Jun; 26(11):. doi: 10.3390/molecules26113435. [PMID: 34198892]
Chenchen Yu, Xixi Cai, Xuejiao Liu, Jianlong Liu, Na Zhu. Betulin Alleviates Myocardial Ischemia-Reperfusion Injury in Rats via Regulating the Siti1/NLRP3/NF-κB Signaling Pathway. Inflammation. 2021 Jun; 44(3):1096-1107. doi: 10.1007/s10753-020-01405-8. [PMID: 33392937]
Hani A Alhadrami, Ahmed M Sayed, Ahmed M Sharif, Esam I Azhar, Mostafa E Rateb. Olive-Derived Triterpenes Suppress SARS COV-2 Main Protease: A Promising Scaffold for Future Therapeutics. Molecules (Basel, Switzerland). 2021 May; 26(9):. doi: 10.3390/molecules26092654. [PMID: 34062737]
André Barreto Cunha, Ronan Batista, María Ángeles Castro, Jorge Mauricio David. Chemical Strategies towards the Synthesis of Betulinic Acid and Its More Potent Antiprotozoal Analogues. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26041081. [PMID: 33670791]
Jerónimo Laiolo, Cecilia L Barbieri, Mariana B Joray, Priscila A Lanza, Sara M Palacios, D Mariano A Vera, María C Carpinella. Plant extracts and betulin from Ligaria cuneifolia inhibit P-glycoprotein function in leukemia cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Jan; 147(?):111922. doi: 10.1016/j.fct.2020.111922. [PMID: 33321149]
Giulia Carolina Lodi, Giuseppe Borsato, Maria Luisa Vázquez de Ágredos Pascual, Francesca Caterina Izzo. Disclosing the composition of unknown historical drug formulations: an emblematic case from the Spezieria of St. Maria della Scala in Rome. Analytical and bioanalytical chemistry. 2020 Nov; 412(27):7581-7593. doi: 10.1007/s00216-020-02893-1. [PMID: 32918172]
Mikhail V Dubinin, Alena A Semenova, Anna I Ilzorkina, Irina B Mikheeva, Valery A Yashin, Nikita V Penkov, Valentina A Vydrina, Gumer Yu Ishmuratov, Vyacheslav A Sharapov, Ekaterina I Khoroshavina, Sergey V Gudkov, Konstantin N Belosludtsev. Effect of betulin and betulonic acid on isolated rat liver mitochondria and liposomes. Biochimica et biophysica acta. Biomembranes. 2020 10; 1862(10):183383. doi: 10.1016/j.bbamem.2020.183383. [PMID: 32522531]
Jing Yin, Lu Sun, Ying Li, Jialei Xiao, Siyao Wang, Jie Yang, Ziyue Qu, Yaguang Zhan. Functional identification of BpMYB21 and BpMYB61 transcription factors responding to MeJA and SA in birch triterpenoid synthesis. BMC plant biology. 2020 Aug; 20(1):374. doi: 10.1186/s12870-020-02521-1. [PMID: 32787836]
Yongjin Wen, Ling Geng, Lin Zhou, Xueliang Pei, Zhiyuan Yang, Zhiwei Ding. Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway. International immunopharmacology. 2020 Aug; 85(?):106653. doi: 10.1016/j.intimp.2020.106653. [PMID: 32531709]
Carlos Calderón, Lara Rubarth, Malgorzata Cebo, Irmgard Merfort, Michael Lämmerhofer. Lipid Atlas of Keratinocytes and Betulin Effects on its Lipidome Profiled by Comprehensive UHPLC-MS/MS with Data Independent Acquisition Using Targeted Data Processing. Proteomics. 2020 06; 20(11):e1900113. doi: 10.1002/pmic.201900113. [PMID: 31489976]
Janeesh Plakkal Ayyappan, Kezia Lizardo, Sean Wang, Edward Yurkow, Jyothi F Nagajyothi. Inhibition of SREBP Improves Cardiac Lipidopathy, Improves Endoplasmic Reticulum Stress, and Modulates Chronic Chagas Cardiomyopathy. Journal of the American Heart Association. 2020 02; 9(3):e014255. doi: 10.1161/jaha.119.014255. [PMID: 31973605]
Gang Wang, Yu-Zhu Wang, Yang Yu, Jun-Jie Wang, Pei-Hao Yin, Ke Xu. Triterpenoids Extracted from Rhus chinensis Mill Act Against Colorectal Cancer by Inhibiting Enzymes in Glycolysis and Glutaminolysis: Network Analysis and Experimental Validation. Nutrition and cancer. 2020; 72(2):293-319. doi: 10.1080/01635581.2019.1631858. [PMID: 31267795]
V Buko, I Kuzmitskaya, S Kirko, E Belonovskaya, E Naruta, O Lukivskaya, A Shlyahtun, T Ilyich, A Zakreska, I Zavodnik. Betulin attenuated liver damage by prevention of hepatic mitochondrial dysfunction in rats with alcoholic steatohepatitis. Physiology international. 2019 Dec; 106(4):323-334. doi: 10.1556/2060.106.2019.26. [PMID: 31619044]
Jianlin Li, Baocheng Jiang, Chen Chen, Boyi Fan, Huilian Huang, Guangtong Chen. Biotransformation of betulin by Mucor subtilissimus to discover anti-inflammatory derivatives. Phytochemistry. 2019 Oct; 166(?):112076. doi: 10.1016/j.phytochem.2019.112076. [PMID: 31351331]
Fan Yin, Fan Feng, Lei Wang, Xiaoning Wang, Zongwei Li, Yu Cao. SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity. Cell death & disease. 2019 09; 10(9):672. doi: 10.1038/s41419-019-1884-7. [PMID: 31511501]
Ranjeet Kumar Nirala, Pratuyasha Dutta, Md Zubbair Malik, Lalita Dwivedi, Tulsidas G Shrivastav, Sonu Chand Thakur. In Vitro and In Silico Evaluation of Betulin on Calcium Oxalate Crystal Formation. Journal of the American College of Nutrition. 2019 Sep; 38(7):586-596. doi: 10.1080/07315724.2019.1568321. [PMID: 30933658]
I E Ojeda-Serna, N E Rocha-Guzmán, J A Gallegos-Infante, M H Cháirez-Ramírez, W Rosas-Flores, J D Pérez-Martínez, M R Moreno-Jiménez, R F González-Laredo. Water-in-oil organogel based emulsions as a tool for increasing bioaccessibility and cell permeability of poorly water-soluble nutraceuticals. Food research international (Ottawa, Ont.). 2019 06; 120(?):415-424. doi: 10.1016/j.foodres.2019.03.011. [PMID: 31000257]
Armin Scheffler. The Wound Healing Properties of Betulin from Birch Bark from Bench to Bedside. Planta medica. 2019 May; 85(7):524-527. doi: 10.1055/a-0850-0224. [PMID: 30856673]
Sameh Soliman, Alshaimaa M Hamoda, Abdel-Nasser A El-Shorbagi, Ali A El-Keblawy. Novel betulin derivative is responsible for the anticancer folk use of Ziziphus spina-christi from the hot environmental habitat of UAE. Journal of ethnopharmacology. 2019 Mar; 231(?):403-408. doi: 10.1016/j.jep.2018.11.040. [PMID: 30508621]
Razieh Jafari Hajati, Vahide Payamnoor, Najmeh Ahmadian Chashmi. Effect of biotic and abiotic elicitors on production of betulin and betulinic acid in the hairy root culture of Betula pendula Roth. Preparative biochemistry & biotechnology. 2019; 49(10):1010-1019. doi: 10.1080/10826068.2019.1650372. [PMID: 31385749]
Sarah D'Adamo, Gino Schiano di Visconte, Gavin Lowe, Joanna Szaub-Newton, Tracey Beacham, Andrew Landels, Michael J Allen, Andrew Spicer, Michiel Matthijs. Engineering the unicellular alga Phaeodactylum tricornutum for high-value plant triterpenoid production. Plant biotechnology journal. 2019 01; 17(1):75-87. doi: 10.1111/pbi.12948. [PMID: 29754445]
Guang-Meng Xu, Tao Zan, Hong-Yan Li, Jin-Feng Han, Zhong-Min Liu, Ju Huang, Li-Hua Dong, Hai-Na Zhang. Betulin inhibits lipopolysaccharide/D-galactosamine-induced acute liver injury in mice through activating PPAR-γ. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Oct; 106(?):941-945. doi: 10.1016/j.biopha.2018.07.011. [PMID: 30119266]
Yulin Ren, Gerardo D Anaya-Eugenio, Austin A Czarnecki, Tran Ngoc Ninh, Chunhua Yuan, Hee-Byung Chai, Djaja D Soejarto, Joanna E Burdette, Esperanza J Carcache de Blanco, A Douglas Kinghorn. Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. Bioorganic & medicinal chemistry. 2018 08; 26(15):4452-4460. doi: 10.1016/j.bmc.2018.07.025. [PMID: 30057155]
Hae Min So, Hee Jeong Eom, Dahae Lee, Sil Kim, Ki Sung Kang, Il Kyun Lee, Kwan-Hyuck Baek, Jun Yeon Park, Ki Hyun Kim. Bioactivity evaluations of betulin identified from the bark of Betula platyphylla var. japonica for cancer therapy. Archives of pharmacal research. 2018 Aug; 41(8):815-822. doi: 10.1007/s12272-018-1064-9. [PMID: 30109574]
Ali Talebi, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, David Nittner, Rita Derua, Frank Vanderhoydonc, Joao A G Duarte, Francesca Bosisio, Kathleen Van den Eynde, Kris Nys, Mónica Vara Pérez, Patrizia Agostinis, Etienne Waelkens, Joost Van den Oord, Sarah-Maria Fendt, Jean-Christophe Marine, Johannes V Swinnen. Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy. Nature communications. 2018 06; 9(1):2500. doi: 10.1038/s41467-018-04664-0. [PMID: 29950559]
Nan Ouyang, Hua Gan, Quan He, Han Lei, Stephen Y Wang, Qing Liu, Chao Zhou. Dysfunction of cholesterol sensor SCAP promotes inflammation activation in THP-1 macrophages. Experimental cell research. 2018 06; 367(2):162-169. doi: 10.1016/j.yexcr.2018.03.032. [PMID: 29596892]
Wendan Zhang, Honghong Jiang, Miaomiao Jin, Qiao Wang, Qian Sun, Yingfeng Du, Liang Cao, Huijun Xu. UHPLC-Q-TOF-MS/MS based screening and identification of the metabolites in vivo after oral administration of betulin. Fitoterapia. 2018 Jun; 127(?):29-41. doi: 10.1016/j.fitote.2018.04.010. [PMID: 29665421]
George R Pettit, Noeleen Melody, Jean-Charles Chapuis. Antineoplastic Agents. 606. The Betulastatins. Journal of natural products. 2018 03; 81(3):458-464. doi: 10.1021/acs.jnatprod.7b00536. [PMID: 29303263]
Razieh Jafari Hajati, Vahide Payamnoor, Najmeh Ahmadian Chashmi, Kamal Ghasemi Bezdi. Improved accumulation of betulin and betulinic acid in cell suspension culture of Betula pendula roth by abiotic and biotic elicitors. Preparative biochemistry & biotechnology. 2018; 48(9):867-876. doi: 10.1080/10826068.2018.1514514. [PMID: 30296385]
Chao-Min Wang, Kuei-Lin Yeh, Shang-Jie Tsai, Yun-Lian Jhan, Chang-Hung Chou. Anti-Proliferative Activity of Triterpenoids and Sterols Isolated from Alstonia scholaris against Non-Small-Cell Lung Carcinoma Cells. Molecules (Basel, Switzerland). 2017 Dec; 22(12):. doi: 10.3390/molecules22122119. [PMID: 29194373]
Xiliang Yang, Qingyun Peng, Qian Liu, Jie Hu, Zhipeng Tang, Lianjie Cui, Zonghao Lin, Bing Xu, Kuojian Lu, Fang Yang, Zhizheng Sheng, Qiong Yuan, Song Liu, Jiuliang Zhang, Xuefeng Zhou. Antioxidant activity against H2O2-induced cytotoxicity of the ethanol extract and compounds from Pyrola decorate leaves. Pharmaceutical biology. 2017 Dec; 55(1):1843-1848. doi: 10.1080/13880209.2017.1333126. [PMID: 28571528]
Lía S Valencia-Chan, Isabel García-Cámara, Luis W Torres-Tapia, Rosa E Moo-Puc, Sergio R Peraza-Sánchez. Lupane-Type Triterpenes of Phoradendron vernicosum. Journal of natural products. 2017 11; 80(11):3038-3042. doi: 10.1021/acs.jnatprod.7b00177. [PMID: 29120172]
Zhiyuan Ma, Yong-Guang Jia, X X Zhu. Glycopolymers Bearing Galactose and Betulin: Synthesis, Encapsulation, and Lectin Recognition. Biomacromolecules. 2017 Nov; 18(11):3812-3818. doi: 10.1021/acs.biomac.7b01106. [PMID: 28982003]
H O B Oloyede, H O Ajiboye, M O Salawu, T O Ajiboye. Influence of oxidative stress on the antibacterial activity of betulin, betulinic acid and ursolic acid. Microbial pathogenesis. 2017 Oct; 111(?):338-344. doi: 10.1016/j.micpath.2017.08.012. [PMID: 28807773]
Braja Gopal Bag, Rakhi Majumdar. Self-assembly of Renewable Nano-sized Triterpenoids. Chemical record (New York, N.Y.). 2017 09; 17(9):841-873. doi: 10.1002/tcr.201600123. [PMID: 28195390]
Guizhi Fan, Tingting Nie, Jin Sheng Fan, Yaguang Zhan. Exogenous Feeding of Fructose and Phenylalanine Further Improves Betulin Production in Suspended Betula platyphylla Cells under Nitric Oxide Treatment. Molecules (Basel, Switzerland). 2017 Jun; 22(7):. doi: 10.3390/molecules22071035. [PMID: 28665342]
Jianan Wu, Yongwu Niu, Abdelmoneim Bakur, Hao Li, Qihe Chen. Cell-Free Production of Pentacyclic Triterpenoid Compound Betulinic Acid from Betulin by the Engineered Saccharomyces cerevisiae. Molecules (Basel, Switzerland). 2017 Jun; 22(7):. doi: 10.3390/molecules22071075. [PMID: 28653998]
Chang Ha Park, Shicheng Zhao, Hyeon Ji Yeo, Ye Eun Park, Thanislas Bastin Baska, Mariadhas Valan Arasu, Naif Abdullah Ai-Dhabi, Sang Un Park. Comparison of Different Strains of Agrobacterium rhizogenes for Hairy Root Induction and Betulin and Betulinic Acid Production in Morus alba. Natural product communications. 2017 Apr; 12(4):479-482. doi: ". [PMID: 30520575]
Olga N Pozharitskaya, Marina V Karlina, Alexander N Shikov, Vera M Kosman, Valery G Makarov, Eudald Casals, Jessica M Rosenholm. Pharmacokinetics and Tissue Disposition of Nanosystem-Entrapped Betulin After Endotracheal Administration to Rats. European journal of drug metabolism and pharmacokinetics. 2017 Apr; 42(2):327-332. doi: 10.1007/s13318-016-0340-7. [PMID: 27155877]
Yong-Qin Zhou, Xiu-Fang Weng, Rui Dou, Xiao-Sheng Tan, Tian-Tian Zhang, Jin-Bo Fang, Xiong-Wen Wu. Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice. Acta pharmacologica Sinica. 2017 Feb; 38(2):201-210. doi: 10.1038/aps.2016.102. [PMID: 27796295]
Wenlong Cheng, Shiqi Ji, Haijian Zhang, Zhixing Han, Qingjun Liu, Jianwen Wang, Hao Ping. mTOR activation is critical for betulin treatment in renal cell carcinoma cells. Biochemical and biophysical research communications. 2017 Jan; 482(4):1030-1036. doi: 10.1016/j.bbrc.2016.11.153. [PMID: 27908730]
Dharmaprakash Viszwapriya, Ganapathy Ashwinkumar Subramenium, Solai Radhika, Shunmugiah Karutha Pandian. Betulin inhibits cariogenic properties of Streptococcus mutans by targeting vicRK and gtf genes. Antonie van Leeuwenhoek. 2017 Jan; 110(1):153-165. doi: 10.1007/s10482-016-0785-3. [PMID: 27757704]
Ma Chunhua, Hongyan Long, Weina Zhu, Zheng Liu, Ruan Jie, Yajie Zhang, Yarui Wang. Betulin inhibited cigarette smoke-induced COPD in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jan; 85(?):679-686. doi: 10.1016/j.biopha.2016.11.079. [PMID: 27899253]
Chunhua Ma, Hongyan Long. Protective effect of betulin on cognitive decline in streptozotocin (STZ)-induced diabetic rats. Neurotoxicology. 2016 12; 57(?):104-111. doi: 10.1016/j.neuro.2016.09.009. [PMID: 27640960]
Ruta Muceniece, Jana Namniece, Ilva Nakurte, Kaspars Jekabsons, Una Riekstina, Baiba Jansone. Pharmacological research on natural substances in Latvia: Focus on lunasin, betulin, polyprenol and phlorizin. Pharmacological research. 2016 11; 113(Pt B):760-770. doi: 10.1016/j.phrs.2016.03.040. [PMID: 27109319]
Vandana Verma, Avinash C Tripathi, Shailendra K Saraf. Bioactive non-sterol triterpenoid from Streblus asper: microwave-assisted extraction, HPTLC profiling, computational studies and neuro-pharmacological evaluation in BALB/c mice. Pharmaceutical biology. 2016 Nov; 54(11):2454-2464. doi: 10.3109/13880209.2016.1160132. [PMID: 27049764]
Yu-Zhou Gui, Hong Yan, Fei Gao, Cong Xi, Hui-Hui Li, Yi-Ping Wang. Betulin attenuates atherosclerosis in apoE-/- mice by up-regulating ABCA1 and ABCG1. Acta pharmacologica Sinica. 2016 Sep; 37(10):1337-1348. doi: 10.1038/aps.2016.46. [PMID: 27374487]
Ankur A Gholkar, Keith Cheung, Kevin J Williams, Yu-Chen Lo, Shadia A Hamideh, Chelsea Nnebe, Cindy Khuu, Steven J Bensinger, Jorge Z Torres. Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division. The Journal of biological chemistry. 2016 08; 291(33):17001-8. doi: 10.1074/jbc.c116.737346. [PMID: 27378817]
Jiajin Li, Hui Yan, Li Zhao, Wenzhi Jia, Hao Yang, Liu Liu, Xiang Zhou, Ping Miao, Xiaoguang Sun, Shaoli Song, Xiaoping Zhao, Jianjun Liu, Gang Huang. Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells. Oncotarget. 2016 Aug; 7(32):52392-52403. doi: 10.18632/oncotarget.10721. [PMID: 27447558]
Yun-ting Cai, Hua-wei Geng. [Chemical Constituents from the Roots of Rhodomyrtus tomentosa]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Jun; 39(6):1303-7. doi: ". [PMID: 30156803]
Dezhi Yang, Ningbo Gong, Li Zhang, Yang Lu. Isostructurality Among 5 Solvatomorphs of Betulin: X-Ray Structure and Characterization. Journal of pharmaceutical sciences. 2016 06; 105(6):1867-1873. doi: 10.1016/j.xphs.2016.03.015. [PMID: 27129904]
Tina Wardecki, Philipp Werner, Maria Thomas, Markus F Templin, Gudula Schmidt, Johanna M Brandner, Irmgard Merfort. Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. Journal of natural products. 2016 Apr; 79(4):1112-23. doi: 10.1021/acs.jnatprod.6b00027. [PMID: 27002382]
Filomena S G Silva, Paulo J Oliveira, Maria F Duarte. Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?. Journal of agricultural and food chemistry. 2016 Apr; 64(15):2991-3008. doi: 10.1021/acs.jafc.5b06021. [PMID: 27012451]
Shengxin Cai, April L Risinger, Shalini Nair, Jiangnan Peng, Timothy J C Anderson, Lin Du, Douglas R Powell, Susan L Mooberry, Robert H Cichewicz. Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants. Journal of natural products. 2016 Mar; 79(3):490-8. doi: 10.1021/acs.jnatprod.5b00874. [PMID: 26722868]
Yao-wu Tao, Ye Tian, Wen-dong Xu, Qing-lan Guo, Jian-gong Shi. [Terpenoids from Euphorbia micractina]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 03; 51(3):411-9. doi: ". [PMID: 29859022]
Ting Bai, Yong Yang, You-Li Yao, Peng Sun, Li-Hua Lian, Yan-Ling Wu, Ji-Xing Nan. Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway. Pharmacological research. 2016 Mar; 105(?):1-12. doi: 10.1016/j.phrs.2015.12.022. [PMID: 26776965]
Ramdhan Yadav, Dharmesh Kumar, Avnesh Kumari, Sudesh Kumar Yadav. PLA nanovectors with encapsulated betulin: plant leaf extract-synthesized nanovectors are more efficacious than PVA-synthesized nanovectors. Biotechnology letters. 2016 Feb; 38(2):259-69. doi: 10.1007/s10529-015-1981-3. [PMID: 26476528]
Hongyu Zhao, Qiang Zheng, Xiao Hu, Haitao Shen, Fengchun Li. Betulin attenuates kidney injury in septic rats through inhibiting TLR4/NF-κB signaling pathway. Life sciences. 2016 Jan; 144(?):185-93. doi: 10.1016/j.lfs.2015.12.003. [PMID: 26656467]
Pavel Šiman, Alžběta Filipová, Alena Tichá, Mohamed Niang, Aleš Bezrouk, Radim Havelek. Effective Method of Purification of Betulin from Birch Bark: The Importance of Its Purity for Scientific and Medicinal Use. PloS one. 2016; 11(5):e0154933. doi: 10.1371/journal.pone.0154933. [PMID: 27152419]
Anna Färber, Rolf Daniels. Ex vivo Skin Permeation of Betulin from Water-in-Oil Foams. Skin pharmacology and physiology. 2016; 29(5):250-256. doi: 10.1159/000448689. [PMID: 27632222]
Namki Cho, Hyeon Woo Kim, Hee Kyoung Lee, Byung Ju Jeon, Sang Hyun Sung. Ameliorative effect of betulin from Betula platyphylla bark on scopolamine-induced amnesic mice. Bioscience, biotechnology, and biochemistry. 2016; 80(1):166-71. doi: 10.1080/09168451.2015.1072460. [PMID: 26287580]
Hongyu Zhao, Zhenning Liu, Wei Liu, Xinfei Han, Min Zhao. Betulin attenuates lung and liver injuries in sepsis. International immunopharmacology. 2016 Jan; 30(?):50-56. doi: 10.1016/j.intimp.2015.11.028. [PMID: 26644168]
Jian Wang, Yang-min Ma, Meng-ru Yan, Qian Xu, Zi-rui Qu, Zhi Miao. [Chemical Compositions from Stems and Branches of Sorbaria arborea]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Oct; 38(10):2098-101. doi: . [PMID: 27254923]
J T Banzouzi, P Njomnang Soh, S Ramos, P Toto, A Cavé, J Hemez, F Benoit-Vical. Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae). Journal of ethnopharmacology. 2015 Sep; 173(?):100-4. doi: 10.1016/j.jep.2015.07.023. [PMID: 26192809]
Li Pan, Ulyana Muñoz Acuña, Heebyung Chai, Hyun-Young Park, Tran Ngoc Ninh, Bui Van Thanh, Emilio F Merino, Maria B Cassera, L Harinantenaina Rakotondraibe, Esperanza J Carcache de Blanco, Djaja D Soejarto, A Douglas Kinghorn. New Bioactive Lupane Triterpene Coumaroyl Esters Isolated from Buxus cochinchinensis. Planta medica. 2015 Aug; 81(12-13):1133-40. doi: 10.1055/s-0035-1546118. [PMID: 26132853]
Nam-Hui Yim, Young Pil Jung, Aeyung Kim, Taesoo Kim, Jin Yeul Ma. Induction of apoptotic cell death by betulin in multidrug-resistant human renal carcinoma cells. Oncology reports. 2015 Aug; 34(2):1058-64. doi: 10.3892/or.2015.4045. [PMID: 26059173]
Svetlana A Myza, Tatyana P Shakhtshneidera, Mikhail A Mikhailenkob, Andrey G Ogienkoc, Ekaterina G Bogdanovaa, Anna A Ogienkoe, Svetlana A Kuznetsovaf, Elena V Boldyrevaa, Vladimir V Boldyreva. Ultrafine Betulin Formulation with Biocompatible Carriers Exhibiting Improved Dissolution Rate. Natural product communications. 2015 Aug; 10(8):1345-7. doi: ". [PMID: 26434111]
Oliver Callies, Luis M Bedoya, Manuela Beltrán, Alejandro Muñoz, Patricia Obregón Calderón, Alex A Osorio, Ignacio A Jiménez, José Alcamí, Isabel L Bazzocchi. Isolation, Structural Modification, and HIV Inhibition of Pentacyclic Lupane-Type Triterpenoids from Cassine xylocarpa and Maytenus cuzcoina. Journal of natural products. 2015 May; 78(5):1045-55. doi: 10.1021/np501025r. [PMID: 25927586]
Haoxin Li, Duncan Webster, John A Johnson, Christopher A Gray. Anti-mycobacterial triterpenes from the Canadian medicinal plant Alnus incana. Journal of ethnopharmacology. 2015 May; 165(?):148-51. doi: 10.1016/j.jep.2015.02.042. [PMID: 25725435]
Yong-zhang Wu, Yu-bo Zhang, Neng-hua Chen, Guo-cai Wang, Yao-lan Li. [Chemical Constituents from Syzygium samarangense Branches and Leaves]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Apr; 38(4):754-7. doi: . [PMID: 26672341]
Ren-Jun Hsu, Yao-Chin Hsu, Shu-Pin Chen, Chia-Lynn Fu, Jyh-Cherng Yu, Fung-Wei Chang, Ying-Hsin Chen, Jui-Ming Liu, Jar-Yi Ho, Cheng-Ping Yu. The triterpenoids of Hibiscus syriacus induce apoptosis and inhibit cell migration in breast cancer cells. BMC complementary and alternative medicine. 2015 Mar; 15(?):65. doi: 10.1186/s12906-015-0592-9. [PMID: 25885960]
Sylwia Katarzyna Król, Michał Kiełbus, Adolfo Rivero-Müller, Andrzej Stepulak. Comprehensive review on betulin as a potent anticancer agent. BioMed research international. 2015; 2015(?):584189. doi: 10.1155/2015/584189. [PMID: 25866796]
H Q Nguyen, V V Chupin, D I Prokhorov, I E Chikunov, V Yu Kovtun, R A Tarumov, A N Grebenyuk, V I Shvets. Creation and study of triterpenoid nanoparticles and radioprotective substance genistein. Doklady. Biochemistry and biophysics. 2015; 464(?):338-40. doi: 10.1134/s160767291505018x. [PMID: 26518563]
Lian-Xia Wang, Zhen-Ming Lu, Yan Geng, Xiao-Mei Zhang, Guo-Hua Xu, Jin-Song Shi, Zheng-Hong Xu. Stimulated production of steroids in Inonotus obliquus by host factors from birch. Journal of bioscience and bioengineering. 2014 Dec; 118(6):728-31. doi: 10.1016/j.jbiosc.2014.05.022. [PMID: 25027706]
M Heidary Navid, M N Laszczyk-Lauer, J Reichling, P Schnitzler. Pentacyclic triterpenes in birch bark extract inhibit early step of herpes simplex virus type 1 replication. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Sep; 21(11):1273-80. doi: 10.1016/j.phymed.2014.06.007. [PMID: 25172789]
Xiuhua Zhao, Weiguo Wang, Yuangang Zu, Ying Zhang, Yong Li, Wei Sun, Chang Shan, Yunlong Ge. Preparation and characterization of betulin nanoparticles for oral hypoglycemic drug by antisolvent precipitation. Drug delivery. 2014 Sep; 21(6):467-79. doi: 10.3109/10717544.2014.881438. [PMID: 24479653]
Anna Ilyina, Roberto Arredondo-Valdés, Salavat Farkhutdinov, Elda Patricia Segura-Ceniceros, José Luis Martínez-Hernández, Radik Zaynullin, Rayhana Kunakova. Effect of betulin-containing extract from birch tree bark on α-amylase activity in vitro and on weight gain of broiler chickens in vivo. Plant foods for human nutrition (Dordrecht, Netherlands). 2014 Mar; 69(1):65-70. doi: 10.1007/s11130-014-0404-2. [PMID: 24445672]