Betulin (BioDeep_00000403518)

Main id: BioDeep_00000000550

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


NCGC00168803-04_C30H50O2_Lup-20(29)-ene-3,28-diol, (3beta)-

化学式: C30H50O2 (442.3811)
中文名称: 桦木脑
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 61.17%

分子结构信息

SMILES: C=C(C)[C@@H]1CC[C@]2(CO)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H]
InChI: InChI=1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1

描述信息

Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.

同义名列表

30 个代谢物同义名

(3.beta.)-Lup-20(29)-ene-3,28-diol; Lup-20(29)-ene-3,28-diol, (3beta)-; Lup-20(30)-ene-3beta,28-diol; Lup-20(29)-ene-3beta,28-diol; Prestwick3_000990; betulinic alcohol; EINECS 207-475-5; BPBio1_001165; BSPBio_001059; MEGxp0_001726; ACon1_000091; ZINC03978650; AIDS-002710; B9757_SIGMA; 18211-63-7; Messagenin; AIDS002710; ST5411404; betulinol; NSC692218; AI3-62999; betuline; NSC 4644; 473-98-3; Betulin; Trochol; C08631; C08618; NCGC00168803-04_C30H50O2_Lup-20(29)-ene-3,28-diol, (3beta)-; Betulin



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

900 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, ANXA5, BCL2, CASP3, CASP9, CAT, CDKN1A, MAPK14, MSMP, MTOR, NFE2L2, PTGS2, TP53
Peripheral membrane protein 4 ANXA5, GORASP1, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 10 AKT1, BCL2, CASP3, CASP9, CDKN1A, HMOX1, MAPK14, MTOR, NFE2L2, TP53
cytosol 13 AKT1, ANXA5, BCL2, CASP3, CASP9, CAT, CDKN1A, GPT, HMOX1, MAPK14, MTOR, NFE2L2, TP53
dendrite 1 MTOR
nuclear body 1 CDKN1A
phagocytic vesicle 1 MTOR
centrosome 2 NFE2L2, TP53
nucleoplasm 8 AKT1, CASP3, CDKN1A, HMOX1, MAPK14, MTOR, NFE2L2, TP53
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 2 AKT1, TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
lamellipodium 1 AKT1
Golgi apparatus membrane 2 GORASP1, MTOR
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 2 GORASP1, NFE2L2
Golgi membrane 3 GORASP1, INS, MTOR
lysosomal membrane 2 GAA, MTOR
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 NFE2L2
Lysosome 2 GAA, MTOR
plasma membrane 4 AKT1, GAA, NFE2L2, TNF
Membrane 8 AKT1, ANXA5, BCL2, CAT, GAA, HMOX1, MTOR, TP53
caveola 1 PTGS2
extracellular exosome 4 ANXA5, CAT, GAA, GPT
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 4 BCL2, HMOX1, PTGS2, TP53
extracellular space 5 HMOX1, IL6, INS, MSMP, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 CDKN1A, HMOX1
mitochondrion 5 BCL2, CASP9, CAT, MAPK14, TP53
protein-containing complex 7 AKT1, BCL2, CASP9, CAT, CDKN1A, PTGS2, TP53
intracellular membrane-bounded organelle 2 CAT, GAA
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 4 GAA, IL6, INS, MSMP
extracellular region 7 ANXA5, CAT, GAA, IL6, INS, MAPK14, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 2 CDKN1A, TP53
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 ANXA5, CAT
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, TP53
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
spindle pole 1 MAPK14
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
tertiary granule membrane 1 GAA
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 NFE2L2
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Prativa Biswasroy, Deepak Pradhan, Dilip Kumar Pradhan, Goutam Ghosh, Goutam Rath. Development of Betulin-Loaded Nanostructured Lipid Carriers for the Management of Imiquimod-Induced Psoriasis. AAPS PharmSciTech. 2024 Mar; 25(3):57. doi: 10.1208/s12249-024-02774-1. [PMID: 38472545]
  • Feyisayo O Adepoju, Ksenia V Sokolova, Irina F Gette, Irina G Danilova, Mikhail V Tsurkan, Alicia C Mondragon, Elena G Kovaleva, Jose Manuel Miranda. Protective Effect of Betulin on Streptozotocin-Nicotinamide-Induced Diabetes in Female Rats. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042166. [PMID: 38396842]
  • Yiding Deng, Ruili Wang, Zhiyuan Ma, Weiwei Zuo, Meifang Zhu. Synthesis and Fabrication of Betulin-Derived Polysulfide and Polysulfoxide Electrospun Fibers for Fruit Preservation. Journal of agricultural and food chemistry. 2023 Dec; 71(48):18857-18864. doi: 10.1021/acs.jafc.3c07117. [PMID: 37994873]
  • Mengdi Lv, Yue Zheng, Jian Wu, Zhengqi Shen, Binglian Guo, Guojing Hu, Yuanlei Huang, Jingyue Zhao, Yong Qian, Zhi Su, Chao Wu, Xuling Xue, Hong-Ke Liu, Zong-Wan Mao. Evoking Ferroptosis by Synergistic Enhancement of a Cyclopentadienyl Iridium-Betulin Immune Agonist. Angewandte Chemie (International ed. in English). 2023 Oct; ?(?):e202312897. doi: 10.1002/anie.202312897. [PMID: 37830171]
  • Umesh Chandra Dash, Sandeep Kumar Swain, Atala Bihari Jena, Jagnehswar Dandapat, Atish Kumar Sahoo. The ameliorative effect of Piper trioicum in attenuating cognitive deficit in scopolamine induced neurotoxicity in experimental rats. Journal of ethnopharmacology. 2023 Jul; ?(?):116911. doi: 10.1016/j.jep.2023.116911. [PMID: 37451488]
  • Kai-Yuan Chen, Wei-Lin Hsu, Shih-Wei Hsu, Chao-Hsuan Chen, Kun-Ting Hong, Chia-Wen Tsai, Wen-Shin Chang, Chao-Chun Chen, Jen-Sheng Pei, Hsu-Tung Lee, DA-Tian Bau. Involvement of Mitochondrial Damage and Oxidative Stress in Apoptosis Induced by Betulin Plus Arsenic Trioxide in Neuroblastoma Cells. Anticancer research. 2023 Jun; 43(6):2467-2476. doi: 10.21873/anticanres.16414. [PMID: 37247918]
  • Maria Błaszczyk, Agata Kozioł, Anna Palko-Łabuz, Kamila Środa-Pomianek, Olga Wesołowska. Modulators of cellular cholesterol homeostasis as antiproliferative and model membranes perturbing agents. Biochimica et biophysica acta. Biomembranes. 2023 May; 1865(6):184163. doi: 10.1016/j.bbamem.2023.184163. [PMID: 37172710]
  • Amira E Farage, Walied Abdo, Amira Osman, Mona A Abdel-Kareem, Zaki H Hakami, Ahmad Alsulimani, Albandari Bin-Ammar, Ashwag S Alanazi, Bader Alsuwayt, Mohammed M Alanazi, Samar A Antar, Emadeldin M Kamel, Ayman M Mahmoud. Betulin prevents high fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress and upregulating Nrf2 and SIRT1 in rats. Life sciences. 2023 Apr; ?(?):121688. doi: 10.1016/j.lfs.2023.121688. [PMID: 37030617]
  • E V Averyanova, M N Shkolnikova, O V Chugunova, O N Mazko. [Effects of triterpenoids in fatty products on liver condition of laboratory animals with acute toxic hepatitis]. Voprosy pitaniia. 2023; 92(4):81-91. doi: 10.33029/0042-8833-2023-92-4-81-91. [PMID: 37801458]
  • Hellen Karla Oliveira Marques, Maria Gabriela Ferreira Figueiredo, Willian Samuel de Souza Pio, Leonardo Monteiro Ribeiro, Islaine Franciely Pinheiro de Azevedo, Lucienir Pains Duarte, Grasiely Faria de Sousa, Mariana Guerra de Aguilar, Maria Olívia Mercadante-Simões. Laticifer ontogenesis and the chemical constituents of Marsdenia zehntneri (Apocynaceae) latex in a semiarid environment. Planta. 2022 Dec; 257(1):19. doi: 10.1007/s00425-022-04050-7. [PMID: 36538159]
  • Ting Ouyang, Huafeng Yin, Jianbo Yang, Yue Liu, Shuangcheng Ma. Tissue regeneration effect of betulin via inhibition of ROS/MAPKs/NF-ĸB axis using zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113420. doi: 10.1016/j.biopha.2022.113420. [PMID: 36076542]
  • Prabhjit Kaur, Saroj Arora, Rajbir Singh. Isolation, characterization and biological activities of betulin from Acacia nilotica bark. Scientific reports. 2022 06; 12(1):9370. doi: 10.1038/s41598-022-13338-3. [PMID: 35672366]
  • Olga V Demets, Altynaray T Takibayeva, Rymchan Z Kassenov, Madina R Aliyeva. Methods of Betulin Extraction from Birch Bark. Molecules (Basel, Switzerland). 2022 Jun; 27(11):. doi: 10.3390/molecules27113621. [PMID: 35684557]
  • Wei-Ya Yan, Jian Cai, Jiang-Nan Wang, Yong-Sheng Gong, Xue-Bing Ding. Co-treatment of betulin and gefitinib is effective against EGFR wild-type/KRAS-mutant non-small cell lung cancer by inducing ferroptosis. Neoplasma. 2022 May; 69(3):648-656. doi: 10.4149/neo_2022_211103n1568. [PMID: 35330996]
  • Mapula Razwinani, Keolebogile Shirley Motaung. The influence of friedelin, resinone, tingenone and betulin of compounds on chondrogenic differentiation of porcine adipose-derived mesenchymal stem cells (pADMSCs). Biochimie. 2022 May; 196(?):234-242. doi: 10.1016/j.biochi.2022.01.018. [PMID: 35121053]
  • Celina Kruszniewska-Rajs, Barbara Strzałka-Mrozik, Magdalena Kimsa-Dudek, Agnieszka Synowiec-Wojtarowicz, Elwira Chrobak, Ewa Bębenek, Stanisław Boryczka, Stanisław Głuszek, Joanna Magdalena Gola. The Influence of Betulin and Its Derivatives EB5 and ECH147 on the Antioxidant Status of Human Renal Proximal Tubule Epithelial Cells. International journal of molecular sciences. 2022 Feb; 23(5):. doi: 10.3390/ijms23052524. [PMID: 35269667]
  • Claudia Vater, Leonie Bosch, Alexandra Mitter, Thomas Göls, Saskia Seiser, Elke Heiss, Adelheid Elbe-Bürger, Michael Wirth, Claudia Valenta, Victoria Klang. Lecithin-based nanoemulsions of traditional herbal wound healing agents and their effect on human skin cells. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2022 Jan; 170(?):1-9. doi: 10.1016/j.ejpb.2021.11.004. [PMID: 34798283]
  • Aleksandra Ostapiuk, Łukasz Kurach, Maciej Strzemski, Jacek Kurzepa, Anna Hordyjewska. Evaluation of Antioxidative Mechanisms In Vitro and Triterpenes Composition of Extracts from Silver Birch (Betula pendula Roth) and Black Birch (Betula obscura Kotula) Barks by FT-IR and HPLC-PDA. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154633. [PMID: 34361786]
  • Augustine A Ahmadu, Claire Delehouzé, Anas Haruna, Lukman Mustapha, Bilqis A Lawal, Aniefiok Udobre, Blandine Baratte, Camilla Triscornia, Axelle Autret, Thomas Robert, Jeannette Chloë Bulinski, Morgane Rousselot, Mélanie Simoes Eugénio, Marie-Thérèse Dimanche-Boitrel, Jacobus P Petzer, Lesetja J Legoabe, Stéphane Bach. Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154599. [PMID: 34361750]
  • Ramona Daniela Pârvănescu Pană, Claudia-Geanina Watz, Elena-Alina Moacă, Lavinia Vlaia, Iasmina Marcovici, Ioana Gabriela Macașoi, Florin Borcan, Ioana Olariu, Georgeta Coneac, George-Andrei Drăghici, Zorin Crăiniceanu, Daniela Flondor Ionescu, Alexandra Enache, Cristina Adriana Dehelean. Oleogel Formulations for the Topical Delivery of Betulin and Lupeol in Skin Injuries-Preparation, Physicochemical Characterization, and Pharmaco-Toxicological Evaluation. Molecules (Basel, Switzerland). 2021 Jul; 26(14):. doi: 10.3390/molecules26144174. [PMID: 34299450]
  • Jinku Zhang, Bingjuan Zhou, Jirui Sun, Hong Chen, Zhao Yang. Betulin ameliorates 7,12-dimethylbenz(a)anthracene-induced rat mammary cancer by modulating MAPK and AhR/Nrf-2 signaling pathway. Journal of biochemical and molecular toxicology. 2021 Jul; 35(7):e22779. doi: 10.1002/jbt.22779. [PMID: 33759307]
  • Yoganathan Kamaraj, Sangeetha Dhayalan, Uma Chinnaiyan, Veenayohini Kumaresan, Satheeshkumar Subramaniyan, Deepak Kumar, Kokila Muniyandi, Ganesh Punamalai. Triterpenoid compound betulin attenuates allergic airway inflammation by modulating antioxidants, inflammatory cytokines and tissue transglutaminase in ovalbumin-induced asthma mice model. The Journal of pharmacy and pharmacology. 2021 Jun; 73(7):968-978. doi: 10.1093/jpp/rgab015. [PMID: 33769499]
  • Andrzej Günther, Edyta Makuch, Anna Nowak, Wiktoria Duchnik, Łukasz Kucharski, Robert Pełech, Adam Klimowicz. Enhancement of the Antioxidant and Skin Permeation Properties of Betulin and Its Derivatives. Molecules (Basel, Switzerland). 2021 Jun; 26(11):. doi: 10.3390/molecules26113435. [PMID: 34198892]
  • Chenchen Yu, Xixi Cai, Xuejiao Liu, Jianlong Liu, Na Zhu. Betulin Alleviates Myocardial Ischemia-Reperfusion Injury in Rats via Regulating the Siti1/NLRP3/NF-κB Signaling Pathway. Inflammation. 2021 Jun; 44(3):1096-1107. doi: 10.1007/s10753-020-01405-8. [PMID: 33392937]
  • Hani A Alhadrami, Ahmed M Sayed, Ahmed M Sharif, Esam I Azhar, Mostafa E Rateb. Olive-Derived Triterpenes Suppress SARS COV-2 Main Protease: A Promising Scaffold for Future Therapeutics. Molecules (Basel, Switzerland). 2021 May; 26(9):. doi: 10.3390/molecules26092654. [PMID: 34062737]
  • André Barreto Cunha, Ronan Batista, María Ángeles Castro, Jorge Mauricio David. Chemical Strategies towards the Synthesis of Betulinic Acid and Its More Potent Antiprotozoal Analogues. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26041081. [PMID: 33670791]
  • Jerónimo Laiolo, Cecilia L Barbieri, Mariana B Joray, Priscila A Lanza, Sara M Palacios, D Mariano A Vera, María C Carpinella. Plant extracts and betulin from Ligaria cuneifolia inhibit P-glycoprotein function in leukemia cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Jan; 147(?):111922. doi: 10.1016/j.fct.2020.111922. [PMID: 33321149]
  • Giulia Carolina Lodi, Giuseppe Borsato, Maria Luisa Vázquez de Ágredos Pascual, Francesca Caterina Izzo. Disclosing the composition of unknown historical drug formulations: an emblematic case from the Spezieria of St. Maria della Scala in Rome. Analytical and bioanalytical chemistry. 2020 Nov; 412(27):7581-7593. doi: 10.1007/s00216-020-02893-1. [PMID: 32918172]
  • Mikhail V Dubinin, Alena A Semenova, Anna I Ilzorkina, Irina B Mikheeva, Valery A Yashin, Nikita V Penkov, Valentina A Vydrina, Gumer Yu Ishmuratov, Vyacheslav A Sharapov, Ekaterina I Khoroshavina, Sergey V Gudkov, Konstantin N Belosludtsev. Effect of betulin and betulonic acid on isolated rat liver mitochondria and liposomes. Biochimica et biophysica acta. Biomembranes. 2020 10; 1862(10):183383. doi: 10.1016/j.bbamem.2020.183383. [PMID: 32522531]
  • Jing Yin, Lu Sun, Ying Li, Jialei Xiao, Siyao Wang, Jie Yang, Ziyue Qu, Yaguang Zhan. Functional identification of BpMYB21 and BpMYB61 transcription factors responding to MeJA and SA in birch triterpenoid synthesis. BMC plant biology. 2020 Aug; 20(1):374. doi: 10.1186/s12870-020-02521-1. [PMID: 32787836]
  • Yongjin Wen, Ling Geng, Lin Zhou, Xueliang Pei, Zhiyuan Yang, Zhiwei Ding. Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway. International immunopharmacology. 2020 Aug; 85(?):106653. doi: 10.1016/j.intimp.2020.106653. [PMID: 32531709]
  • Carlos Calderón, Lara Rubarth, Malgorzata Cebo, Irmgard Merfort, Michael Lämmerhofer. Lipid Atlas of Keratinocytes and Betulin Effects on its Lipidome Profiled by Comprehensive UHPLC-MS/MS with Data Independent Acquisition Using Targeted Data Processing. Proteomics. 2020 06; 20(11):e1900113. doi: 10.1002/pmic.201900113. [PMID: 31489976]
  • Janeesh Plakkal Ayyappan, Kezia Lizardo, Sean Wang, Edward Yurkow, Jyothi F Nagajyothi. Inhibition of SREBP Improves Cardiac Lipidopathy, Improves Endoplasmic Reticulum Stress, and Modulates Chronic Chagas Cardiomyopathy. Journal of the American Heart Association. 2020 02; 9(3):e014255. doi: 10.1161/jaha.119.014255. [PMID: 31973605]
  • Gang Wang, Yu-Zhu Wang, Yang Yu, Jun-Jie Wang, Pei-Hao Yin, Ke Xu. Triterpenoids Extracted from Rhus chinensis Mill Act Against Colorectal Cancer by Inhibiting Enzymes in Glycolysis and Glutaminolysis: Network Analysis and Experimental Validation. Nutrition and cancer. 2020; 72(2):293-319. doi: 10.1080/01635581.2019.1631858. [PMID: 31267795]
  • V Buko, I Kuzmitskaya, S Kirko, E Belonovskaya, E Naruta, O Lukivskaya, A Shlyahtun, T Ilyich, A Zakreska, I Zavodnik. Betulin attenuated liver damage by prevention of hepatic mitochondrial dysfunction in rats with alcoholic steatohepatitis. Physiology international. 2019 Dec; 106(4):323-334. doi: 10.1556/2060.106.2019.26. [PMID: 31619044]
  • Jianlin Li, Baocheng Jiang, Chen Chen, Boyi Fan, Huilian Huang, Guangtong Chen. Biotransformation of betulin by Mucor subtilissimus to discover anti-inflammatory derivatives. Phytochemistry. 2019 Oct; 166(?):112076. doi: 10.1016/j.phytochem.2019.112076. [PMID: 31351331]
  • Fan Yin, Fan Feng, Lei Wang, Xiaoning Wang, Zongwei Li, Yu Cao. SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity. Cell death & disease. 2019 09; 10(9):672. doi: 10.1038/s41419-019-1884-7. [PMID: 31511501]
  • Ranjeet Kumar Nirala, Pratuyasha Dutta, Md Zubbair Malik, Lalita Dwivedi, Tulsidas G Shrivastav, Sonu Chand Thakur. In Vitro and In Silico Evaluation of Betulin on Calcium Oxalate Crystal Formation. Journal of the American College of Nutrition. 2019 Sep; 38(7):586-596. doi: 10.1080/07315724.2019.1568321. [PMID: 30933658]
  • I E Ojeda-Serna, N E Rocha-Guzmán, J A Gallegos-Infante, M H Cháirez-Ramírez, W Rosas-Flores, J D Pérez-Martínez, M R Moreno-Jiménez, R F González-Laredo. Water-in-oil organogel based emulsions as a tool for increasing bioaccessibility and cell permeability of poorly water-soluble nutraceuticals. Food research international (Ottawa, Ont.). 2019 06; 120(?):415-424. doi: 10.1016/j.foodres.2019.03.011. [PMID: 31000257]
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