Mangiferol (BioDeep_00000003897)

Main id: BioDeep_00000230176

 

human metabolite PANOMIX_OTCML-2023 Antitumor activity natural product


代谢物信息卡片


1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9H-xanthen-9-one

化学式: C19H18O11 (422.0849)
中文名称: 芒果苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc1c(c2=O)cc(c(c1)O)O)O)[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O
InChI: InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1

描述信息

Mangiferol, also known as alpizarin or chinomin, is a member of the class of compounds known as xanthones. Xanthones are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring. Mangiferol is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Mangiferol can be found in mango, which makes mangiferol a potential biomarker for the consumption of this food product.
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities[1][2][3].
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities[1][2][3].

同义名列表

12 个代谢物同义名

1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9H-xanthen-9-one; (1S)-1,5-anhydro-1-(1,3,6,7-tetrahydroxy-9-oxo-9H-xanthen-2-yl)-D-glucitol; 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one; 2-beta-D-Glucopyranosyl-1,3,6,7-tetrahydroxy xanthone; Mangiferol; Mangiferin; Hedysarid; alpizarin; Chinomin; Aphloiol; chinonin; Mangiferin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

436 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, AKT1, BCL2, BCL2L1, CTNNB1, MTOR, NFE2L2, PIK3CA, PPARG, PTGS2
Peripheral membrane protein 3 ACHE, MTOR, PTGS2
Endoplasmic reticulum membrane 3 BCL2, MTOR, PTGS2
Mitochondrion membrane 1 BCL2L1
Nucleus 8 ACHE, AKT1, BCL2, CTNNB1, MTOR, NFE2L2, PPARA, PPARG
cytosol 8 AKT1, BCL2, BCL2L1, CTNNB1, MTOR, NFE2L2, PIK3CA, PPARG
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 3 BCL2L1, CTNNB1, NFE2L2
nucleoplasm 6 AKT1, CTNNB1, MTOR, NFE2L2, PPARA, PPARG
RNA polymerase II transcription regulator complex 2 NFE2L2, PPARG
Cell membrane 5 ABCB1, ACHE, AKT1, CTNNB1, TNF
Cytoplasmic side 2 BCL2L1, MTOR
lamellipodium 3 AKT1, CTNNB1, PIK3CA
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 MTOR
Synapse 2 ACHE, CTNNB1
cell cortex 2 AKT1, CTNNB1
cell junction 1 CTNNB1
cell surface 3 ABCB1, ACHE, TNF
glutamatergic synapse 2 AKT1, CTNNB1
Golgi apparatus 2 ACHE, NFE2L2
Golgi membrane 2 INS, MTOR
lysosomal membrane 2 GAA, MTOR
mitochondrial inner membrane 1 BCL2L1
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
postsynapse 1 AKT1
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 2 BCL2L1, NFE2L2
Lysosome 2 GAA, MTOR
plasma membrane 8 ABCB1, ACHE, AKT1, CTNNB1, GAA, NFE2L2, PIK3CA, TNF
synaptic vesicle membrane 1 BCL2L1
Membrane 7 ABCB1, ACHE, AKT1, BCL2, CTNNB1, GAA, MTOR
apical plasma membrane 1 ABCB1
axon 1 CCK
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 3 ABCB1, CTNNB1, GAA
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 3 BCL2, BCL2L1, PTGS2
extracellular space 8 ACHE, CCK, CCL2, CXCL8, IL10, IL4, INS, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 4 ACHE, CTNNB1, PIK3CA, PPARG
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, BCL2L1
protein-containing complex 4 AKT1, BCL2, CTNNB1, PTGS2
intracellular membrane-bounded organelle 2 GAA, PPARG
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 8 ACHE, CCK, CCL2, CXCL8, GAA, IL10, IL4, INS
extracellular region 9 ACHE, CCK, CCL2, CXCL8, GAA, IL10, IL4, INS, TNF
Mitochondrion outer membrane 3 BCL2, BCL2L1, MTOR
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 3 BCL2, BCL2L1, MTOR
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
Extracellular side 1 ACHE
transcription regulator complex 1 CTNNB1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 2 BCL2, BCL2L1
external side of plasma membrane 1 TNF
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 1 CTNNB1
spindle 1 AKT1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
basement membrane 1 ACHE
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 3 NFE2L2, PPARA, PPARG
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
Lipid-anchor, GPI-anchor 1 ACHE
microvillus membrane 1 CTNNB1
nuclear envelope 1 MTOR
Endomembrane system 2 CTNNB1, MTOR
endosome lumen 1 INS
tertiary granule membrane 1 GAA
euchromatin 1 CTNNB1
side of membrane 1 ACHE
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic active zone cytoplasmic component 1 CTNNB1
synaptic cleft 1 ACHE
protein-DNA complex 2 CTNNB1, NFE2L2
ficolin-1-rich granule membrane 1 GAA
external side of apical plasma membrane 1 ABCB1
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
[Isoform H]: Cell membrane 1 ACHE
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Zhaoxia Li, Zhiliang Gao, Cong Chang, Zhuanglei Gao. Anticonvulsive Effect of Glucosyl Xanthone Mangiferin on Pentylenetetrazol (PTZ)-Induced Seizure-Provoked Mice. Applied biochemistry and biotechnology. 2024 Apr; 196(4):2161-2175. doi: 10.1007/s12010-023-04651-2. [PMID: 37486538]
  • He-Wei Ji, Chao-Rui Wang, Xiu-Wen Yuan, Jing Wang, Lin Wang, Qi-Long Cao, Ying-Hua Li, Yong-Nan Xu, Nam-Hyung Kim. Mangiferin improves early porcine embryonic development by reducing oxidative stress. Reproduction in domestic animals = Zuchthygiene. 2024 Apr; 59(4):e14565. doi: 10.1111/rda.14565. [PMID: 38646981]
  • Ying Zhao, Jian- Wu Li. Quantification of mangiferin in streptozotocin-induced diabetic rat plasma using UPLC-MS/MS: Pharmacokinetic assessment of Gentiana rhodantha extract after oral administration. Pakistan journal of pharmaceutical sciences. 2024 Mar; 37(2):291-296. doi: ". [PMID: 38767095]
  • Xuehui Deng, Bingfeng Lin, Fang Wang, Pingcui Xu, Nani Wang. Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1/Nrf2/SLC7A11/GPX4 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155282. doi: 10.1016/j.phymed.2023.155282. [PMID: 38176266]
  • Wanran Huang, Yanni Wang, Wei Huang. Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway. Neuroscience letters. 2024 Jan; 821(?):137608. doi: 10.1016/j.neulet.2023.137608. [PMID: 38142926]
  • Chuihao Kong, Kaidi Wang, Lei Sun, Hongsu Zhao, Tongsheng Wang, Wuxi Zhou, Deling Wu, Fengqing Xu. Novel Carbon Dots Derived from Moutan Cortex Significantly Improve the Solubility and Bioavailability of Mangiferin. International journal of nanomedicine. 2024; 19(?):3611-3622. doi: 10.2147/ijn.s456053. [PMID: 38660022]
  • Gelin Xiang, Sa Guo, Nan Xing, Qinyun Du, Jing Qin, Huimin Gao, Yi Zhang, Shaohui Wang. Mangiferin, a Potential Supplement to Improve Metabolic Syndrome: Current Status and Future Opportunities. The American journal of Chinese medicine. 2024; 52(2):355-386. doi: 10.1142/s0192415x24500150. [PMID: 38533569]
  • Jelena Zivković, Kammala Ananth Kumar, Rapuru Rushendran, Kaliappan Ilango, Nouran M Fahmy, Heba A S El-Nashar, Mohamed El-Shazly, Shahira M Ezzat, Guiomar Melgar-Lalanne, Alejandra Romero-Montero, Sheila I Peña-Corona, Gerardo Leyva-Gomez, Javad Sharifi-Rad, Daniela Calina. Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Sep; ?(?):. doi: 10.1007/s00210-023-02682-4. [PMID: 37658210]
  • Yanmei Zhong, Yingying Xu, Yongzhen Tan, Xuanxuan Zhang, Ruolun Wang, Danmin Chen, Zhaotao Wang, Xunlong Zhong. Lipidomics of the erythrocyte membrane and network pharmacology to explore the mechanism of mangiferin from Anemarrhenae rhizoma in treating type 2 diabetes mellitus rats. Journal of pharmaceutical and biomedical analysis. 2023 Jun; 230(?):115386. doi: 10.1016/j.jpba.2023.115386. [PMID: 37044004]
  • Bethanie Dean, Gemma Cooper, Maitreyi Shivkumar, Timothy J Snape. Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43. Bioorganic & medicinal chemistry letters. 2023 03; 84(?):129211. doi: 10.1016/j.bmcl.2023.129211. [PMID: 36863494]
  • Lijun Zhang, Chuhe Liu, Liufang Yin, Cheng Huang, Shengjie Fan. Mangiferin relieves CCl4-induced liver fibrosis in mice. Scientific reports. 2023 Mar; 13(1):4172. doi: 10.1038/s41598-023-30582-3. [PMID: 36914687]
  • Xiangcheng Fan, Guangyang Jiao, Tao Pang, Tao Wen, Zhiqing He, Jun Han, Feng Zhang, Wansheng Chen. Ameliorative effects of mangiferin derivative TPX on insulin resistance via PI3K/AKT and AMPK signaling pathways in human HepG2 and HL-7702 hepatocytes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154740. doi: 10.1016/j.phymed.2023.154740. [PMID: 36965373]
  • Tusheema Dutta, Tuyelee Das, Abilash Valsala Gopalakrishnan, Suchismita Chatterjee Saha, Mimosa Ghorai, Samapika Nandy, Manoj Kumar, Radha, Arabinda Ghosh, Nobendu Mukerjee, Abhijit Dey. Mangiferin: the miraculous xanthone with diverse pharmacological properties. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Jan; ?(?):. doi: 10.1007/s00210-022-02373-6. [PMID: 36656353]
  • Chuanping Zhao, Zejiang Pu, Jian Gao, Chang Liu, Jianzhong Xing, Wenbo Lang, Jinting Chen, Chunmao Yuan, Chengyan Zhou. "Multiomics" Analyses Combined with Systems Pharmacology Reveal the Renoprotection of Mangiferin Monosodium Salt in Rats with Diabetic Nephropathy: Focus on Improvements in Renal Ferroptosis, Renal Inflammation, and Podocyte Insulin Resistance. Journal of agricultural and food chemistry. 2023 Jan; 71(1):358-381. doi: 10.1021/acs.jafc.2c05595. [PMID: 36519207]
  • Suhuan Mei, Manivel Perumal, Maurizio Battino, David D Kitts, Jianbo Xiao, Haile Ma, Xiumin Chen. Mangiferin: a review of dietary sources, absorption, metabolism, bioavailability, and safety. Critical reviews in food science and nutrition. 2023; 63(18):3046-3064. doi: 10.1080/10408398.2021.1983767. [PMID: 34606395]
  • Irengbam Rocky Mangangcha, Raj Kumar Brojen Singh, Djamel Lebeche, Shakir Ali. Xanthone glucoside 2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one binds to the ATP-binding pocket of glycogen synthase kinase 3β and inhibits its activity: implications in prostate cancer and associated cardiovascular disease risk. Journal of biomolecular structure & dynamics. 2022 10; 40(17):7868-7884. doi: 10.1080/07391102.2021.1902857. [PMID: 33769184]
  • Min Feng, Shaoqiang Wei, Shidong Zhang, Ying Yang. Anti-Inflammation and Anti-Pyroptosis Activities of Mangiferin via Suppressing NF-κB/NLRP3/GSDMD Signaling Cascades. International journal of molecular sciences. 2022 Sep; 23(17):. doi: 10.3390/ijms231710124. [PMID: 36077522]
  • Xia Mao, Yudong Liu, Weijie Li, Kexin Wang, Congchong Li, Qian Wang, Wenjia Chen, Zhaochen Ma, Xiaoyue Wang, Zihe Ding, Yanqiong Zhang, Na Lin. A promising drug combination of mangiferin and glycyrrhizic acid ameliorates disease severity of rheumatoid arthritis by reversing the disturbance of thermogenesis and energy metabolism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154216. doi: 10.1016/j.phymed.2022.154216. [PMID: 35749826]
  • Andy Gálvez-Rodríguez, Anthuan Ferino-Pérez, Zalua Rodríguez-Riera, Idania Rodeiro Guerra, David Řeha, Babak Minofar, Ulises J Jáuregui-Haza. Explaining the interaction of mangiferin with MMP-9 and NF-ƙβ: a computational study. Journal of molecular modeling. 2022 Aug; 28(9):266. doi: 10.1007/s00894-022-05260-2. [PMID: 35987945]
  • Debora Santonocito, Maria Vivero-Lopez, Maria Rosaria Lauro, Cristina Torrisi, Francesco Castelli, Maria Grazia Sarpietro, Carmelo Puglia. Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study. Molecules (Basel, Switzerland). 2022 Feb; 27(4):. doi: 10.3390/molecules27041328. [PMID: 35209120]
  • Ying Wang, Tanushree Karmakar, Nilanjan Ghosh, Souvik Basak, Nanda Gopal Sahoo. Targeting mangiferin loaded N-succinyl chitosan-alginate grafted nanoparticles against atherosclerosis - A case study against diabetes mediated hyperlipidemia in rat. Food chemistry. 2022 Feb; 370(?):131376. doi: 10.1016/j.foodchem.2021.131376. [PMID: 34662793]
  • Sumaya Akter, Akhi Moni, Golam Mahbub Faisal, Muhammad Ramiz Uddin, Nourin Jahan, Md Abdul Hannan, Asadur Rahman, Md Jamal Uddin. Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives. International journal of environmental research and public health. 2022 02; 19(3):. doi: 10.3390/ijerph19031864. [PMID: 35162887]
  • Weijie Li, Kexin Wang, Yudong Liu, Hao Wu, Yan He, Congchong Li, Qian Wang, Xiaohui Su, Shikai Yan, Weiwei Su, Yanqiong Zhang, Na Lin. A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis. Frontiers in immunology. 2022; 13(?):912933. doi: 10.3389/fimmu.2022.912933. [PMID: 35799788]
  • Qi Zhou, Kezhu Hou, Zhiqiang Fu. Transferrin-Modified Mangiferin-Loaded SLNs: Preparation, Characterization, and Application in A549 Lung Cancer Cell. Drug design, development and therapy. 2022; 16(?):1767-1778. doi: 10.2147/dddt.s366531. [PMID: 35707686]
  • Lesslie Espinosa-Espinosa, Leticia Garduño-Siciliano, Mario Rodriguez-Canales, Luis Barbo Hernandez-Portilla, Maria Margarita Canales-Martinez, Marco Aurelio Rodriguez-Monroy. The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model. Molecules (Basel, Switzerland). 2022 Jan; 27(1):. doi: 10.3390/molecules27010259. [PMID: 35011491]
  • Ohn Mar Lwin, Nelli Giribabu, Eswar Kumar Kilari, Naguib Salleh. Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats. The Journal of dermatological treatment. 2021 Dec; 32(8):1039-1048. doi: 10.1080/09546634.2020.1721419. [PMID: 32013660]
  • Ran Wang, Jing Liu, Zhehuan Wang, Xiaohan Wu, Hui Guo, Xiangyue Jiao, Huiru Zhang, Caihong Qi, Xiaotian Li. Mangiferin exert protective effects on joints of adjuvant-induced arthritis rats by regulating the MAPKs/NF-κB pathway of fibroblast-like synoviocytes. International immunopharmacology. 2021 Dec; 101(Pt B):108352. doi: 10.1016/j.intimp.2021.108352. [PMID: 34836794]
  • Magdy M Awny, Asmaa K Al-Mokaddem, Bassam Mohamed Ali. Mangiferin mitigates di-(2-ethylhexyl) phthalate-induced testicular injury in rats by modulating oxidative stress-mediated signals, inflammatory cascades, apoptotic pathways, and steroidogenesis. Archives of biochemistry and biophysics. 2021 10; 711(?):108982. doi: 10.1016/j.abb.2021.108982. [PMID: 34400143]
  • Anna Hering, Jadwiga Renata Ochocka, Helena Baranska, Krzysztof Cal, Justyna Stefanowicz-Hajduk. Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts (Cyclopia sp.)-A Comparison Ex Vivo Study. Molecules (Basel, Switzerland). 2021 Oct; 26(21):. doi: 10.3390/molecules26216547. [PMID: 34770957]
  • Tian-Feng Lin, Jun-Na Qiu, Shuang Zhang, Yan Zhang, Yu Zhang, Meng Sun, Jin-Hua Zhang, Bin Liu, Fa-Feng Cheng, Yan-Yan Jiang. Screening out the anti-insomnia components from Prunella vulgaris L. based on plasma pharmacochemistry combined with pharmacodynamic experiments and UPLC-MS/MS analysis. Journal of ethnopharmacology. 2021 Oct; 279(?):114373. doi: 10.1016/j.jep.2021.114373. [PMID: 34181959]
  • Min Liu, Chengquan Wen, Shengqi Pan. Modulator effect of mangiferin on biochemical characterization in 7,12-dimethylbenz[a]anthracene induced oral cancer in experimental hamsters. Veterinary medicine and science. 2021 09; 7(5):2015-2025. doi: 10.1002/vms3.500. [PMID: 33949808]
  • Prabhjot Kaur, R C Gupta, Abhijit Dey, Tabarak Malik, Devendra Kumar Pandey. Optimization of harvest and extraction factors by full factorial design for the improved yield of C-glucosyl xanthone mangiferin from Swertia chirata. Scientific reports. 2021 08; 11(1):16346. doi: 10.1038/s41598-021-95663-7. [PMID: 34381094]
  • Tingjun Liu, Yuanjian Song, Ankang Hu. Neuroprotective mechanisms of mangiferin in neurodegenerative diseases. Drug development research. 2021 06; 82(4):494-502. doi: 10.1002/ddr.21783. [PMID: 33458836]
  • Salita Demeyer, Anan Athipornchai, Pariya Pabunrueang, Thanida Trakulsujaritchok. Development of mangiferin loaded chitosan-silica hybrid scaffolds: Physicochemical and bioactivity characterization. Carbohydrate polymers. 2021 Jun; 261(?):117905. doi: 10.1016/j.carbpol.2021.117905. [PMID: 33766383]
  • Zhi Tang, Chen-Cen Lai, Jun Luo, Yuan-Ting Ding, Qian Chen, Zhi-Zhong Guan. Mangiferin prevents the impairment of mitochondrial dynamics and an increase in oxidative stress caused by excessive fluoride in SH-SY5Y cells. Journal of biochemical and molecular toxicology. 2021 Apr; 35(4):e22705. doi: 10.1002/jbt.22705. [PMID: 33393728]
  • You Wu, Wei Liu, Tao Yang, Mei Li, Lingling Qin, Lili Wu, Tonghua Liu. Oral administration of mangiferin ameliorates diabetes in animal models: a meta-analysis and systematic review. Nutrition research (New York, N.Y.). 2021 03; 87(?):57-69. doi: 10.1016/j.nutres.2020.12.017. [PMID: 33601215]
  • Vaibhav Walia, Sushil Kumar Chaudhary, Neeraj Kumar Sethiya. Therapeutic potential of mangiferin in the treatment of various neuropsychiatric and neurodegenerative disorders. Neurochemistry international. 2021 02; 143(?):104939. doi: 10.1016/j.neuint.2020.104939. [PMID: 33346032]
  • Karim Naraki, Ramin Rezaee, Habibeh Mashayekhi-Sardoo, A Wallace Hayes, Gholamreza Karimi. Mangiferin offers protection against deleterious effects of pharmaceuticals, heavy metals, and environmental chemicals. Phytotherapy research : PTR. 2021 Feb; 35(2):810-822. doi: 10.1002/ptr.6864. [PMID: 32961631]
  • Lijun Zhang, Cheng Huang, Shengjie Fan. Mangiferin and organ fibrosis: A mini review. BioFactors (Oxford, England). 2021 Jan; 47(1):59-68. doi: 10.1002/biof.1693. [PMID: 33217771]
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