Cuc B (BioDeep_00001867495)

Main id: BioDeep_00000000391

 

PANOMIX_OTCML-2023


代谢物信息卡片


(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

化学式: C32H46O8 (558.3192516)
中文名称: 葫芦苦素 B, 葫芦素 B, 葫芦素B, 雪胆甲素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(C(=O)C4(C)C)O)C)C)C)O)O
InChI: InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1

描述信息

Cucurbitacin B is a cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated. It is a cucurbitacin, a secondary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It derives from a hydride of a lanostane.
Cucurbitacin B is a natural product found in Begonia plebeja, Trichosanthes miyagii, and other organisms with data available.
A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity[1][2][3][4][5].
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity[1][2][3][4][5].

同义名列表

36 个代谢物同义名

(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate; [(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate; (3E,6R)-6-[(1R,2R,4S,10S,11S,13R,14R,15R)-4,13-dihydroxy-1,6,6,11,15-pentamethyl-5,17-dioxotetracyclo[8.7.0.0?,?.0??,??]heptadec-7-en-14-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate; 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2.beta.,9.beta.,10.alpha.,16.alpha.,23E)-; (2.BETA.,9.BETA.,10.ALPHA.,16.ALPHA.,23E)-25-(ACETYLOXY)-2,16,20-TRIHYDROXY-9-METHYL-19-NORLANOSTA-5,23-DIENE-3,11,22-TRIONE; (2S,4R,23E)-2,16beta,20-trihydroxy-9beta,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate; 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2beta,9beta,10alpha,16alpha,23E)-; 19-Norlanosta-5,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, [2.beta.,.gamma.,.beta.,10.alpha.,16.alpha.]-; 19-Norlanosta-5,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2.beta.,9.beta.,10.alpha.,16.alpha.,23E)-; (2beta,9beta,10alpha,16alpha,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-Norlanosta-5,23-diene-3,11,22-trione; 19-Nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione, 2-beta,16-alpha,20,25-tetrahydroxy-9-methyl-, 25-acetate; 19-Nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione, 2beta,16alpha,20,25-tetrahydroxy-9-methyl-, 25-acetate; 2beta,16alpha,20,25-tetrahydroxy-9-methyl-3,11,22-trioxo-19-nor-9beta,10alpha-lanosta-5,23-dien-25-yl acetate; 2beta,16alpha,20,25-tetrahydroxy-9-methyl-19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione, 25-acetate; 19-nor-9.beta.,23-diene-3,11,22-trione, 9-methyl-2.beta.,16.alpha.,20,25-tetrahydroxy-, 25-acetate; 25-(Acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione; Cucurbitacin B hydrate, >=97\\% (HPLC); CUCURBITACIN R - DATISCA PRINCIPLE B; 1,2-DIHYDRO-.ALPHA.-ELATERIN; 1,2-Dihydro-alpha-elaterin; cucurbitacin B 2-sulfate; Cucurbitacin B hydrate; CUCURBITACIN B [INCI]; Datiscn Principle B; Datisca principle B; CUCURBITACIN B [MI]; (+)-Cucurbitacin B; Cucurbitacine (B); Cucurbitacine B; Cucurbitacin-B; Cucurbitacin B; Cucurbitacin; ST 32:6;O8; DATISCACIN; Amarine; Cuc B



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

87 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Carina Stein, Johanna Voigts, Lisa Niederreiter, Stefanie Kowarschik, Roman Huber, Volker M Lüth. Antiproliferative and immunomodulative potential of Citrullus colocynthis and its bioactive compounds in human lymphocytes and lung cells. Journal of ethnopharmacology. 2024 Jun; 328(?):118053. doi: 10.1016/j.jep.2024.118053. [PMID: 38499257]
  • Hong Wu, Tianjun Ma, Mei He, Wenkai Xie, Xueyan Wang, Liuping Lu, Hui Wang, Ying Cui. Cucurbitacin B modulates M2 macrophage differentiation and attenuates osteosarcoma progression via PI3K/AKT pathway. Phytotherapy research : PTR. 2024 May; 38(5):2215-2233. doi: 10.1002/ptr.8146. [PMID: 38411031]
  • Qi-Zhang Li, Yu-Ying Chen, Qiu-Ping Liu, Zhi-Hui Feng, Lei Zhang, Hong Zhang. Cucurbitacin B suppresses hepatocellular carcinoma progression through inducing DNA damage-dependent cell cycle arrest. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155177. doi: 10.1016/j.phymed.2023.155177. [PMID: 38412667]
  • Shu Dai, Rui Wu, Ke Fu, Yanzhi Li, Chenghao Yao, Yanfang Liu, Fang Zhang, Shenglin Zhang, Yiling Guo, Yuxin Yao, Yunxia Li. Exploring the effect and mechanism of cucurbitacin B on cholestatic liver injury based on network pharmacology and experimental verification. Journal of ethnopharmacology. 2024 Mar; 322(?):117584. doi: 10.1016/j.jep.2023.117584. [PMID: 38104874]
  • Filiz Bakar-Ates, Erva Ozkan. Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation. Toxicology in vitro : an international journal published in association with BIBRA. 2023 Nov; ?(?):105732. doi: 10.1016/j.tiv.2023.105732. [PMID: 37956772]
  • Sandipan Jana, Srijon Gayen, Barun Dasgupta, Seha Singha, Jayashree Mondal, Amit Kar, Abhimanyu Nepal, Suparna Ghosh, Rajan Rajabalaya, Sheba R David, Ashok Kumar Balaraman, Asis Bala, Pulok K Mukerjee, Pallab Kanti Haldar. Investigation on anti-diabetic efficacy of a Cucurbitaceae food plant from the North-East region of India: Exploring the molecular mechanism through modulation of oxidative stress and glycosylated hemoglobin (HbA1c). Endocrine, metabolic & immune disorders drug targets. 2023 Sep; ?(?):. doi: 10.2174/1871530323666230907115818. [PMID: 37691221]
  • Ahmed A Ishola, Kayode E Adewole, Joseph O Adebayo, Elizabeth A Balogun. Potentials of Terpenoids as Inhibitors of Multiple Plasmodium falciparum Protein Drug Targets. Acta parasitologica. 2023 Aug; ?(?):. doi: 10.1007/s11686-023-00711-z. [PMID: 37603126]
  • Guizhou Hu, Wenya Liu, Liyan Li. Identification and quantification of cucurbitacin in watermelon frost using molecular networking integrated with ultra-high-performance liquid chromatography-tandem mass spectrometry. Journal of separation science. 2023 Jun; ?(?):e2300019. doi: 10.1002/jssc.202300019. [PMID: 37269211]
  • Qi Wang, Xiaohui Li, Chen Zhang, Ning Yue, Simeng Li, Xueying Chen, Fen Jin, Hua Shao, Jing Wang. Discovery and Identification of the Key Contributor to the Bitter Taste in Oriental Melon after Forchlorfenuron Application. Journal of agricultural and food chemistry. 2023 Apr; 71(16):6415-6423. doi: 10.1021/acs.jafc.3c00380. [PMID: 37039537]
  • Shu Dai, Cheng Wang, XingTao Zhao, Cheng Ma, Ke Fu, Yanfang Liu, Cheng Peng, Yunxia Li. Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics. Pharmacological research. 2023 01; 187(?):106587. doi: 10.1016/j.phrs.2022.106587. [PMID: 36460279]
  • Haoyue Zhang, Bei Zhao, HuiZhen Wei, Hairong Zeng, Dongya Sheng, Yang Zhang. Cucurbitacin B controls M2 macrophage polarization to suppresses metastasis via targeting JAK-2/STAT3 signalling pathway in colorectal cancer. Journal of ethnopharmacology. 2022 Apr; 287(?):114915. doi: 10.1016/j.jep.2021.114915. [PMID: 34954267]
  • Zhiyong Liu, Manish Kumar, Atul Kabra. Cucurbitacin B exerts neuroprotection in a murine Alzheimer's disease model by modulating oxidative stress, inflammation, and neurotransmitter levels. Frontiers in bioscience (Landmark edition). 2022 02; 27(2):71. doi: 10.31083/j.fbl2702071. [PMID: 35227014]
  • Tingting Chen, Bingxiang Ma, Shi Lu, Lupeng Zeng, Huaying Wang, Wanhua Shi, Linying Zhou, Yaokun Xia, Xi Zhang, Jing Zhang, Jinghua Chen. Cucumber-Derived Nanovesicles Containing Cucurbitacin B for Non-Small Cell Lung Cancer Therapy. International journal of nanomedicine. 2022; 17(?):3583-3599. doi: 10.2147/ijn.s362244. [PMID: 35974872]
  • Pornpatsorn Lertphadungkit, Xue Qiao, Supaart Sirikantaramas, Veena Satitpatipan, Min Ye, Somnuk Bunsupa. De novo transcriptome analysis and identification of candidate genes associated with triterpenoid biosynthesis in Trichosanthes cucumerina L. Plant cell reports. 2021 Oct; 40(10):1845-1858. doi: 10.1007/s00299-021-02748-8. [PMID: 34228189]
  • Miwako Toyofuku, Daiki Fujinaga, Kazue Inaba, Tomoki Funahashi, Yuuta Fujikawa, Hideshi Inoue, Hiroshi Kataoka, Ryusuke Niwa, Hajime Ono. The plant-derived triterpenoid, cucurbitacin B, but not cucurbitacin E, inhibits the developmental transition associated with ecdysone biosynthesis in Drosophila melanogaster. Journal of insect physiology. 2021 10; 134(?):104294. doi: 10.1016/j.jinsphys.2021.104294. [PMID: 34389412]
  • Renyikun Yuan, Wentong Zhao, Qin-Qin Wang, Jia He, Shan Han, Hongwei Gao, Yulin Feng, Shilin Yang. Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis. Pharmacological research. 2021 08; 170(?):105748. doi: 10.1016/j.phrs.2021.105748. [PMID: 34217831]
  • Xiaoli Wang, Yudi Bai, Xue Yan, Jin Li, Bingxue Lin, Linzhi Dai, Cheng Xu, Hua Li, Dong Li, Tai Yang, Tao Zhang. Cucurbitacin B exhibits antitumor effects on CD133+ HepG2 liver cancer stem cells by inhibiting JAK2/STAT3 signaling pathway. Anti-cancer drugs. 2021 06; 32(5):548-557. doi: 10.1097/cad.0000000000001062. [PMID: 33675610]
  • Shuai Huang, Bihui Cao, Jinling Zhang, Yunfei Feng, Lu Wang, Xiaopei Chen, Hang Su, Shengrong Liao, Jinggong Liu, Jun Yan, Baoxia Liang. Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential. Cell death & disease. 2021 03; 12(3):237. doi: 10.1038/s41419-021-03516-y. [PMID: 33664249]
  • Xiaoli Wang, Hua Li, Dong Li, Yudi Bai, Yao Zhang, Xue Yan, Jin Li, Ri Zhao, Jiahui Liu, Wei Liu, Maolin Shi, Cheng Xu, Tai Yang, Tao Zhang. Sorafenib and CuB exert synergistic antitumor effects against hepatocellular carcinoma cells via inhibition of STAT3 phosphorylation. FEBS open bio. 2021 01; 11(1):133-145. doi: 10.1002/2211-5463.13035. [PMID: 33176070]
  • Xianjing Zhang, Huihui Li, Wenqiong Wang, Tong Chen, Lijiang Xuan. Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives. Journal of natural products. 2020 12; 83(12):3536-3544. doi: 10.1021/acs.jnatprod.0c00364. [PMID: 33269591]
  • Li Yang, Qinfang Ao, Qingmei Zhong, Wen Li, Wenhong Li. SIRT1/IGFBPrP1/TGF β1 axis involved in cucurbitacin B ameliorating concanavalin A-induced mice liver fibrosis. Basic & clinical pharmacology & toxicology. 2020 Nov; 127(5):371-379. doi: 10.1111/bcpt.13446. [PMID: 32452080]
  • Qi Tian, Jianbo Guo, Qi Zhang, Liang Fang, Chao Liu, Hui Xu. Development and Evaluation of Cucurbitacin B Microemulsion: the Effect of Oil Phase and Aqueous Phase on Drug Percutaneous Absorption Based on ATR-FTIR Spectroscopy and Molecular Modeling. AAPS PharmSciTech. 2020 Sep; 21(7):258. doi: 10.1208/s12249-020-01797-8. [PMID: 32895882]
  • Fei Luo, Qi Li, Lei Yu, Chengyang Wang, Hongyan Qi. High concentrations of CPPU promotes cucurbitacin B accumulation in melon (Cucumis melo var. makuwa Makino) fruit by inducing transcription factor CmBt. Plant physiology and biochemistry : PPB. 2020 Sep; 154(?):770-781. doi: 10.1016/j.plaphy.2020.05.033. [PMID: 32827970]
  • Filiz Bakar-Ates, Erva Ozkan, Ceyda Tuba Sengel-Turk. Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage. International journal of pharmaceutics. 2020 Aug; 586(?):119565. doi: 10.1016/j.ijpharm.2020.119565. [PMID: 32592898]
  • Xiaoyi Zhang, Xiuyao Zhang, Xinxin Cai, Ruifen Li. [Simultaneous determination of cucurbitacin B, E and I in plasma, urine, and melon and fruit vegetables by ultra performance liquid chromatography-triple quadrupole mass spectrometry using atmospheric pressure chemical ionization]. Se pu = Chinese journal of chromatography. 2020 May; 38(5):564-571. doi: 10.3724/sp.j.1123.2019.09018. [PMID: 34213241]
  • Md Shahiduzzaman, Refaat Ras, Giovanni Widmer. Effect of Ginsenoside-Rh2 and Curcurbitacin-B on Cryptosporidium parvum in vitro. Experimental parasitology. 2020 May; 212(?):107873. doi: 10.1016/j.exppara.2020.107873. [PMID: 32165146]
  • Phatu W Mashela, Ebrahim Shokoohi, Kgabo M Pofu. Morphological adjustment in free-living Steinernema feltiae infective juveniles to increasing concentration of Nemafric-BL phytonematicide. PloS one. 2020; 15(1):e0227448. doi: 10.1371/journal.pone.0227448. [PMID: 31899763]
  • Sirinapha Klungsaeng, Veerapol Kukongviriyapan, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunprai. Targeted Modulation of FAK/PI3K/PDK1/AKT and FAK/p53 Pathways by Cucurbitacin B for the Antiproliferation Effect Against Human Cholangiocarcinoma Cells. The American journal of Chinese medicine. 2020; 48(6):1475-1489. doi: 10.1142/s0192415x2050072x. [PMID: 32907364]
  • Parichat Suebsakwong, Jie Wang, Phorntip Khetkam, Natthida Weerapreeyakul, Jing Wu, Yun Du, Zhu-Jun Yao, Jian-Xin Li, Apichart Suksamrarn. A Bioreductive Prodrug of Cucurbitacin B Significantly Inhibits Tumor Growth in the 4T1 Xenograft Mice Model. ACS medicinal chemistry letters. 2019 Oct; 10(10):1400-1406. doi: 10.1021/acsmedchemlett.9b00161. [PMID: 31620225]
  • Natthaphon Hunsakunachai, Nitra Nuengchamnong, Weena Jiratchariyakul, Tanawan Kummalue, Phisit Khemawoot. Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats. BMC complementary and alternative medicine. 2019 Jul; 19(1):157. doi: 10.1186/s12906-019-2568-7. [PMID: 31272429]
  • Hidayat Hussain, Ivan R Green, Muhammad Saleem, Khanzadi F Khattak, Muhammad Irshad, Maroof Ali. Cucurbitacins as Anticancer Agents: A Patent Review. Recent patents on anti-cancer drug discovery. 2019; 14(2):133-143. doi: 10.2174/1574892813666181119123035. [PMID: 30451116]
  • Hafiz Kamran Yousaf, Tisheng Shan, Xuewei Chen, Kangsheng Ma, Xueyan Shi, Nicolas Desneux, Antonio Biondi, Xiwu Gao. Impact of the secondary plant metabolite Cucurbitacin B on the demographical traits of the melon aphid, Aphis gossypii. Scientific reports. 2018 11; 8(1):16473. doi: 10.1038/s41598-018-34821-w. [PMID: 30405179]
  • Yushuang Liu, Guangying Chen, Xiaoyu Chen, Shi-Xin Chen, Li-She Gan, Tao Yuan. Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis. Journal of natural products. 2018 09; 81(9):2115-2119. doi: 10.1021/acs.jnatprod.8b00461. [PMID: 30183289]
  • Carlotta Granchi. ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism. European journal of medicinal chemistry. 2018 Sep; 157(?):1276-1291. doi: 10.1016/j.ejmech.2018.09.001. [PMID: 30195238]
  • Xian-Mei Piao, Feng Gao, Jiu-Xin Zhu, Li-Juan Wang, Xin Zhao, Xin Li, Miao-Miao Sheng, Yan Zhang. Cucurbitacin B inhibits tumor angiogenesis by triggering the mitochondrial signaling pathway in endothelial cells. International journal of molecular medicine. 2018 Aug; 42(2):1018-1025. doi: 10.3892/ijmm.2018.3647. [PMID: 29717773]
  • Chuanshan Zou, Guifen Liu, Suning Liu, Shumin Liu, Qisheng Song, Jian Wang, Qili Feng, Yunlin Su, Sheng Li. Cucurbitacin B acts a potential insect growth regulator by antagonizing 20-hydroxyecdysone activity. Pest management science. 2018 Jun; 74(6):1394-1403. doi: 10.1002/ps.4817. [PMID: 29205800]
  • Yang Xiao, Zheng Yang, Qing-Qing Wu, Xiao-Han Jiang, Yuan Yuan, Wei Chang, Zhou Yan Bian, Jin Xiu Zhu, Qi-Zhu Tang. Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy. Journal of cellular biochemistry. 2017 11; 118(11):3899-3910. doi: 10.1002/jcb.26041. [PMID: 28390176]
  • Zhibin Wang, Wenbo Zhu, Mingjie Gao, Chengcui Wu, Chunjuan Yang, Jing Yang, Gaosong Wu, Bingyou Yang, Haixue Kuang. Simultaneous determination of cucurbitacin B and cucurbitacin E in rat plasma by UHPLC-MS/MS: A pharmacokinetics study after oral administration of cucurbitacin tablets. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Oct; 1065-1066(?):63-69. doi: 10.1016/j.jchromb.2017.09.024. [PMID: 28946127]
  • Lucas Lourenço Marostica, André Luís Branco de Barros, Juliana Oliveira, Breno Souza Salgado, Geovanni Dantas Cassali, Elaine Amaral Leite, Valbert Nascimento Cardoso, Karen Luise Lang, Miguel Soriano Balparda Caro, Fernando Javier Durán, Eloir Paulo Schenkel, Mônica Cristina de Oliveira, Cláudia Maria Oliveira Simões. Antitumor effectiveness of a combined therapy with a new cucurbitacin B derivative and paclitaxel on a human lung cancer xenograft model. Toxicology and applied pharmacology. 2017 08; 329(?):272-281. doi: 10.1016/j.taap.2017.06.007. [PMID: 28610991]
  • Nicole Bajcsik, Rudolf Pfab, Jörg Pietsch. Simultaneous determination of cucurbitacin B, E, I and E-glucoside in plant material and body fluids by HPLC-MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 May; 1052(?):128-134. doi: 10.1016/j.jchromb.2017.03.030. [PMID: 28376351]
  • Shu Hua, Xing Liu, Shuguang Lv, Zhifang Wang. Protective Effects of Cucurbitacin B on Acute Lung Injury Induced by Sepsis in Rats. Medical science monitor : international medical journal of experimental and clinical research. 2017 Mar; 23(?):1355-1362. doi: 10.12659/msm.900523. [PMID: 28315572]
  • Sonam Sinha, Sajid Khan, Samriddhi Shukla, Amar Deep Lakra, Sudhir Kumar, Gunjan Das, Rakesh Maurya, Syed Musthapa Meeran. Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis. The international journal of biochemistry & cell biology. 2016 08; 77(Pt A):41-56. doi: 10.1016/j.biocel.2016.05.014. [PMID: 27210504]
  • Waiou Zhao, Dahai Xu, Weiwei Yan, Yushi Wang, Nan Zhang. Development and validation of a UPLC-MS/MS method for the determination of cucurbitacin B in rat plasma and application to a pharmacokinetic study. Biomedical chromatography : BMC. 2016 Apr; 30(4):503-7. doi: 10.1002/bmc.3571. [PMID: 26207321]
  • Samriddhi Shukla, Sonam Sinha, Sajid Khan, Sudhir Kumar, Kavita Singh, Kalyan Mitra, Rakesh Maurya, Syed Musthapa Meeran. Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis. Scientific reports. 2016 Feb; 6(?):21860. doi: 10.1038/srep21860. [PMID: 26905250]
  • Yanan Niu, Wen Sun, Jin-Jian Lu, Dik-Lung Ma, Chung-Hang Leung, Lixia Pei, Xiuping Chen. PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells. Oxidative medicine and cellular longevity. 2016; 2016(?):4313204. doi: 10.1155/2016/4313204. [PMID: 28042385]
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