Classification Term: 168377

Cholesterol and derivatives [ST0101] (ontology term: 2463fa0c35e60fc31bd0f6d2a4c2a47a)

Cholesterol and derivatives [ST0101]

found 342 associated metabolites at sub_class metabolite taxonomy ontology rank level.

Ancestor: Sterols [ST01]

Child Taxonomies: There is no child term of current ontology term.

Cucurbitacin_E

[(E,6R)-6-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate

C32H44O8 (556.3036024)


Cucurbitacin E is a cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23. It is a cucurbitacin and a tertiary alpha-hydroxy ketone. Cucurbitacin E is a natural product found in Cucurbita foetidissima, Helicteres angustifolia, and other organisms with data available. A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23. Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex. Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.

   

Cucurbitacin B

(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

C32H46O8 (558.3192516)


Together wth other cucurbitacins, is responsible for the bitter taste and toxic props. of spoilt cucumbers. Cucurbitacin B is found in many foods, some of which are muskmelon, bitter gourd, green vegetables, and cucumber. Cucurbitacin B is found in bitter gourd. Together wth other cucurbitacins, is responsible for the bitter taste and toxic properties of spoilt cucumber Cucurbitacin B is a cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated. It is a cucurbitacin, a secondary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It derives from a hydride of a lanostane. Cucurbitacin B is a natural product found in Begonia plebeja, Trichosanthes miyagii, and other organisms with data available. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity[1][2][3][4][5]. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity[1][2][3][4][5]. (+)-Cucurbitacin B. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=6199-67-3 (retrieved 2024-08-12) (CAS RN: 6199-67-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

   

Inokosterone

(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2R,3R,6R)-2,3,7-trihydroxy-6-methyl-heptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one

C27H44O7 (480.3086874)


Inokosterone is a 2beta-hydroxy steroid, a 3beta-hydroxy steroid, a 14alpha-hydroxy steroid, a 20-hydroxy steroid, a 26-hydroxy steroid, a 6-oxo steroid, a 22-hydroxy steroid and a phytoecdysteroid. Inokosterone is a natural product found in Zoanthus, Rhaponticum carthamoides, and other organisms with data available.

   

Cucurbitacin

(1S,2S,4R,6S,9S,10R,11R,14R,15R)-17-hydroxy-6-(2-hydroxypropan-2-yl)-2,9,11,14,19,19-hexamethyl-5-oxapentacyclo[12.8.0.02,11.04,10.015,20]docosa-16,20-diene-8,13,18-trione

C30H42O6 (498.2981232)


Cucurbitacin S is an 11-oxo steroid. Cucurbitacin S is a natural product found in Cucurbita foetidissima with data available. Triterpenes that derive from LANOSTEROL by a shift of the C19 methyl to the C9 position. They are found in seeds and roots of CUCURBITACEAE and other plants and are noted for intense bitterness.

   

Cucurbitacin D

17-[(E)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthrene-3,11-dione

C30H44O7 (516.3086874)


Cucurbitacin D is a cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23. It is a cucurbitacin, a secondary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It derives from a hydride of a lanostane. Cucurbitacin D is a natural product found in Elaeocarpus chinensis, Elaeocarpus hainanensis, and other organisms with data available. Cucurbitacin D is found in calabash. Cucurbitacin D is isolated from plants of the Cucurbitacea Cucurbitacin D is an active component in Trichosanthes kirilowii, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity[1]. Cucurbitacin D is an active component in Trichosanthes kirilowii, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity[1].

   

elatericin B

(8S,9R,10R,13R,14S,16R,17R)-17-[(E,1R)-1,5-dihydroxy-1,5-dimethyl-2-oxo-hex-3-enyl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthrene-3,11-dione

C30H42O7 (514.2930382)


Cucurbitacin I is a cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene substituted by hydroxy groups at positions 2, 16, 20 and 25 and oxo groups at positions 1, 11 and 22. It has a role as a plant metabolite and an antineoplastic agent. It is a cucurbitacin and a tertiary alpha-hydroxy ketone. Cucurbitacin I is a natural product found in Elaeocarpus chinensis, Elaeocarpus hainanensis, and other organisms with data available. A cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene substituted by hydroxy groups at positions 2, 16, 20 and 25 and oxo groups at positions 1, 11 and 22. Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.

   

25d20E

(2S,3R,5R,9R,10R,13R,14S,17S)-17-((2R,3R)-2,3-dihydroxy-6-methylheptan-2-yl)-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6(10H)-one

C27H44O6 (464.3137724)


Ponasterone A is a 2beta-hydroxy steroid, a 3beta-hydroxy steroid, a 14alpha-hydroxy steroid, a 20-hydroxy steroid, a 22-hydroxy steroid, a 6-oxo steroid and a phytoecdysteroid. Ponasterone A is a natural product found in Zoanthus, Lomaridium contiguum, and other organisms with data available. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones Ponasterone A (25-Deoxyecdysterone), an ecdysteroid, has strong affinity for the ecdysone receptor. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly[1][2].

   

CucurbitacinA

[(E,5R)-5-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-9-(hydroxymethyl)-4,4,13,14-tetramethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate

C32H46O9 (574.3141666)


Cucurbitacin A is a cucurbitacin. Cucurbitacin A is a natural product found in Hintonia standleyana, Cucumis prophetarum, and other organisms with data available.

   

24,25-Dihydrolanosterol

(3S,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

C30H52O (428.4017942)


24,25-dihydrolanosterol is a 3beta-sterol formed from lanosterol by reduction across the C-24-C-25 double bond. It has a role as a human metabolite and a mouse metabolite. It is a 3beta-sterol and a tetracyclic triterpenoid. It is functionally related to a lanosterol. 24,25-Dihydrolanosterol is a natural product found in Euphorbia sapinii, Heterobasidion annosum, and other organisms with data available. 24,25-dihydrolanosterol is a metabolite found in or produced by Saccharomyces cerevisiae. 24,25-Dihydrolanosterol is involved in the biosynthesis of steriods. 24,25-Dihydrolanosterol is reversibly converted to lanosterol by delta24-sterol reductase [EC:1.3.1.72]. A 3beta-sterol formed from lanosterol by reduction across the C-24-C-25 double bond. 24,25-Dihydrolanosterol (Lanostenol) is a component of the seeds of red pepper (Capsicum annuum)[1].

   

ST 24:4;O5

1beta,3beta,14beta-trihydroxy-5beta-bufa-20,22-dienolide

C24H34O5 (402.24061140000003)


C78276 - Agent Affecting Digestive System or Metabolism > C66913 - Cholagogues or Choleretic Agents D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts D005765 - Gastrointestinal Agents > D002793 - Cholic Acids Same as: D01693

   

Crustecdysone

(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-((2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl)-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]phenanthren-6-one

C27H44O7 (480.3086874)


20-hydroxyecdysone is an ecdysteroid that is ecdysone substituted by a hydroxy group at position 20. It has a role as a plant metabolite and an animal metabolite. It is a 20-hydroxy steroid, an ecdysteroid, a 14alpha-hydroxy steroid, a 3beta-sterol, a 2beta-hydroxy steroid, a 22-hydroxy steroid, a 25-hydroxy steroid and a phytoecdysteroid. It is functionally related to an ecdysone. 20-Hydroxyecdysone is a natural product found in Asparagus filicinus, Trichobilharzia ocellata, and other organisms with data available. A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE. Crustecdysone is found in crustaceans. Crustecdysone is isolated from the marine crayfish Jasus lalandei in low yield (2 mg/ton D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones An ecdysteroid that is ecdysone substituted by a hydroxy group at position 20. COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)[3]. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)[3].

   

Epi-coprostanol

(1S,2S,5R,7S,10R,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-ol

C27H48O (388.37049579999996)


Epi-coprostanol, also known as epicholestanol or presteron, belongs to the class of organic compounds known as cholesterols and derivatives. Cholesterols and derivatives are compounds containing a 3-hydroxylated cholestane core. Thus, epi-coprostanol is considered to be a sterol lipid molecule. Epi-coprostanol is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. Epi-coprostanol is a 27 carbon stanol formed from the biohydrogenation of cholesterol (cholest-5en-3β-ol) in the gut of most higher animals and birds. It is a breakdown product of 5b-coprastanol and can be found in treated sewage. It is considered to be an antioxidant and is a major constituent of ambergris. [HMDB] Same as: D01527

   

Polypodine B

(2beta,3beta,5beta,22R)-2,3,5,14,20,22,25-heptahydroxycholest-7-en-6-one

C27H44O8 (496.3036024)


   

ecdysone

17-(3,6-dihydroxy-6-methylheptan-2-yl)-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one

C27H44O6 (464.3137724)


A 6-oxo steroid that is 5beta-cholest-7-en-6-one substituted by hydroxy groups at positions 2, 3, 14, 22 and 25 respectively (the 2beta, 3beta, 22R stereoisomer). It is a steroid prohormone of the major insect moulting hormone 20-hydroxyecdysone. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones Ecdysone, also known as molting hormone, belongs to pentahydroxy bile acids, alcohols and derivatives class of compounds. Those are bile acids, alcohols or derivatives bearing five hydroxyl groups. Thus, ecdysone is considered to be a sterol lipid molecule. Ecdysone is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Ecdysone can be synthesized from 5beta-cholestane. Ecdysone is also a parent compound for other transformation products, including but not limited to, (25R)-11alpha,20,26-trihydroxyecdysone, (24R)-11alpha,20,24-trihydroxyecdysone, and ecdysone 25-O-D-glucopyranoside. Ecdysone can be found in spinach, which makes ecdysone a potential biomarker for the consumption of this food product. Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands. Insect molting hormones (ecdysone and its homologues) are generally called ecdysteroids. Ecdysteroids act as moulting hormones of arthropods but also occur in other related phyla where they can play different roles. In Drosophila melanogaster, an increase in ecdysone concentration induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Recent findings in Chris Q. Doe lab have found a novel role of this hormone in regulating temporal gene transitions within neural stem cells. Ecdysone and other ecdysteroids also appear in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. These phytoecdysteroids have been reputed to have medicinal value and are part of herbal adaptogenic remedies like Cordyceps, yet an ecdysteroid precursor in plants has been shown to have cytotoxic properties. A pesticide sold with the name MIMIC has ecdysteroid activity, although its chemical structure has little resemblance to the ecdysteroids . Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979)[1][2].

   

Cholesteryl glucoside

cholest-5-en-3beta-yl beta-D-glucopyranoside

C33H56O6 (548.4076676)


   

Cucurbitacin F

2,3,16,20,25-Pentahydroxy-9-methyl-19-norlanosta-5,23-diene-11,22-dione (2beta,3alpha,9beta,10alpha,16alpha,23E)-

C30H46O7 (518.3243365999999)


   
   

Cucurbitacin L

Dihydrocucurbitacin I

C30H44O7 (516.3086874)


   

Cucurbitacin P

Cucurbitacin IIb

C30H48O7 (520.3399858)


   
   

Pterosterone

2beta,3beta,14alpha,20R,22R,24S-hexahydroxy-5beta-cholest-7-en-6-one

C27H44O7 (480.3086874)


   

4,4-Dimethylcholesta-8,14,24-trienol

(2S,5S,7R,14R,15R)-2,6,6,15-tetramethyl-14-[(2R)-6-methylhept-5-en-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(10),11-dien-5-ol

C29H46O (410.3548466)


4,4-Dimethylcholesta-8,14,24-trienol is a product of the enzyme delta14-sterol reductase [EC 1.3.1.70] (KEGG). It is involved in the biosynthesis of steroids and is involved in the conversion of lanosterol to zymosterol. In particular, lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4-Dimethylcholesta-8,14,24-trienol in the ergosterol biosynthesis pathway. It is thought to be a meiosis activating sterol. [HMDB] 4,4-Dimethylcholesta-8,14,24-trienol is a product of the enzyme delta14-sterol reductase [EC 1.3.1.70] (KEGG). It is involved in the biosynthesis of steroids and is involved in the conversion of lanosterol to zymosterol. In particular, lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4-Dimethylcholesta-8,14,24-trienol in the ergosterol biosynthesis pathway. It is thought to be a meiosis activating sterol.

   

3-beta-Hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde

(1R,2R,11R,14R,15R)-5-hydroxy-2,6,15-trimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-9-ene-6-carbaldehyde

C29H48O2 (428.36541079999995)


3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde is part of the Steroid biosynthesis pathway. It is a substrate for: Methylsterol monooxygenase 1, and Methylsterol monooxygenase 1.

   

ST 27:4;O6

Hydrocortisone caproate; [2-(11,17-Dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl]hexanoate

C27H40O6 (460.28247400000004)


Same as: D09796

   

24-Hydroxycholesterol

(1S,2R,5S,10S,11S,14R,15R)-14-[(2R,5S)-5-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-5-ol

C27H46O2 (402.34976159999997)


24-Hydroxycholesterol (24OHC) is almost exclusively formed in the brain. The enzymatic conversion of CNS cholesterol to 24OHC, which readily crosses the blood-brain barrier, is the major pathway for brain cholesterol elimination and brain cholesterol homeostasis maintenance. The enzyme mediating this conversion has been characterized at the molecular level as cholesterol 24-hydroxylase (EC 1.14.13.98, CYP46) and is mainly located in neurons. Like other oxysterols, 24OHC is efficiently converted into normal bile acids or excreted in bile in its sulfated and glucuronidated form. Levels of 24OHC in the circulation decrease with age in infants and children. In adults, however, the levels appear to be stable. There is accumulating evidence pointing toward a potentially important link between cholesterol, beta-amyloid, and Alzheimers disease. Patients with active demyelinating diseases had increased levels of 24OHC in cerebrospinal fluid (CSF). Patients with Alzheimers disease have slightly increased levels of 24OHC in CSF. Patients with multiple sclerosis have a tendency to have higher levels of 24OHC during active periods. (PMID: 15061359, 14574622). 24-Hydroxycholesterol has been found to accumulate in hereditary hypercholesterolemia, an inborn error of metabolism. 24-Hydroxycholesterol (24OHC) is almost exclusively formed in the brain. The enzymatic conversion of CNS cholesterol to 24OHC, which readily crosses the blood-brain barrier, is the major pathway for brain cholesterol elimination and brain cholesterol homeostasis maintenance. The enzyme mediating this conversion has been characterized at the molecular level as cholesterol 24-hydroxylase (EC 1.14.13.98, CYP46) and is mainly located in neurons. Like other oxysterols, 24OHC is efficiently converted into normal bile acids or excreted in bile in its sulfated and glucuronidated form. Levels of 24OHC in the circulation decrease with age in infants and children. In adults, however, the levels appear to be stable. There is accumulating evidence pointing toward a potentially important link between cholesterol, beta-amyloid, and Alzheimers disease. Patients with active demyelinating diseases had increased levels of 24OHC in cerebrospinal fluid (CSF). Patients with Alzheimers disease have slightly increased levels of 24OHC in CSF. Patients with multiple sclerosis have a tendency to have higher levels of 24OHC during active periods. (PMID: 15061359, 14574622) [HMDB] 24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3]. 24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].

   

Coprostenol

3beta-Hydroxycholest-4-ene

C27H46O (386.3548466)


   

ST 27:2;O2

(22,23-dinor)-24-vinyl-cholest-5-en-3beta,24-diol

C27H44O2 (400.3341124)


   

5,6-24(S),25-Diepoxycholesterol

5,6-24(S),25-Diepoxycholesterol; (24S,25)-Epoxycholesterol alpha-epoxide

C27H44O3 (416.3290274)


   

ST 28:1;O

14alpha-methyl-5alpha-cholest-9(11)-en-3beta-ol

C28H48O (400.37049579999996)


A brassinosteroid that is 5alpha-campestane bearing an oxo substituent at position 3.

   

ST 28:1;O2

4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol

C28H48O2 (416.36541079999995)


   

3-Keto-4-methylzymosterol

(2S,15R)-2,6,15-trimethyl-14-[(2R)-6-methylhept-5-en-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-1(10)-en-5-one

C28H44O (396.3391974)


3-Keto-4-methylzymosterol is an intermediate in the biosynthesis of steroids (KEGG:C15816). It is the 8th to last step in the synthesis of vitamin D2 and is converted from 4-methtylzymosterol-carboxylate via the enzyme sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC:1.1.1.170). It is then converted to 4-methylzymosterol via the enzyme 3-keto steroid reductase (EC:1.1.1.270). [HMDB]. 3-Keto-4-methylzymosterol is found in many foods, some of which are sweet cherry, horseradish tree, eggplant, and dill. 3-Keto-4-methylzymosterol is an intermediate in the biosynthesis of steroids (KEGG:C15816). It is the 8th to last step in the synthesis of vitamin D2 and is converted from 4-methtylzymosterol-carboxylate via the enzyme sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC:1.1.1.170). It is then converted to 4-methylzymosterol via the enzyme 3-keto steroid reductase (EC:1.1.1.270).

   

ST 29:1;O

4alpha,14alpha-dimethyl-5alpha-cholest-9(11)-en-3beta-ol

C29H50O (414.386145)


A cholestanoid that is 5alpha-cholesta-8-en-3beta-ol bearing two additional methyl substituents at position 4.

   

ST 27:2;O3

3beta,5beta-Ketodiol; 2,22,25-Trideoxyecdysone; 3beta,14alpha-Dihydroxy-5beta-cholest-7-en-6-one

C27H44O3 (416.3290274)


   

FT-0697108

(3beta,5beta,22R)-3,14,22,25-Tetrahydroxycholest-7-en-6-one

C27H44O5 (448.3188574)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

   

ST 27:2;O8

NCGC00385426-01!2,3,14-trihydroxy-10,13-dimethyl-17-(2,3,6,7-tetrahydroxy-6-methylheptan-2-yl)-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one

C27H44O8 (496.3036024)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

   

27-Hydroxycholesterol

(1S,2R,5S,10S,11S,14R,15R)-14-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol

C27H46O2 (402.34976159999997)


27-Hydroxycholesterol (27-HC), also known as (25R)-cholest-5-ene-3β,26-diol or by its conventional name 26-hydroxycholesterol, is an oxygenated derivative of cholesterol and a major oxysterol in circulation (PMID: 7749852). 27-Hydroxycholesterol is the product of the enzyme sterol 27-hydroxylase. The enzyme is critical for the degradation of the steroid side-chain and a genetic deficiency of the enzyme leads to reduced formation of bile acids in humans. There is a correlation between 27-hydroxycholesterol and cholesterol in the circulation, and females have lower levels of 27-hydroxycholesterol than males. A strong correlation is observed between circulating levels of 27-hydroxycholesterol and cholesterol, in both healthy subjects and subjects with hypercholesterolemia and documented atherosclerosis. 27-Hydroxycholesterol is metabolized by an oxysterol 7alpha-hydroxylase in the liver. Changes in the activity of this enzyme may lead to the accumulation of 27-hydroxycholesterol in the circulation. It has been reported that patients with a genetic deficiency of oxysterol 7alpha-hydroxylase in the liver had markedly increased levels of 27-hydroxycholesterol in the circulation. However, under normal conditions and in the absence of liver or kidney disease, changes in the levels of 27-hydroxycholesterol in the circulation are likely to be caused by changes in the rate of synthesis of these steroids rather than by the rate of metabolism. There are three possible explanations for the high concentrations of 27-hydroxycholesterol found in the circulation of three subjects with atherosclerosis: (1) increased expression of sterol 27-hydroxylase owing to a genetic factor or some other factor completely unrelated to atherosclerosis, (2) the extrahepatic sterol 27-hydroxylase may be up-regulated by circulating factors (e.g. cytokines) that are directly or indirectly related to the development of atherosclerosis, and (3) the high amounts of cholesterol accumulating in macrophages in some patients with atherosclerosis may result in an increased flux of 27-hydroxycholesterol from the macrophages to the circulation. Since there is a close relation between levels of cholesterol and 27-hydroxycholesterol in the circulation, the possibility must be considered that the flux of 27-hydroxycholesterol into the brain may be part of the yet unexplained link between hypercholesterolemia and Alzheimers disease. 27-Hydroxysterol is the most dominant oxysterol in human atheromas where it may reflect a mechanism for eliminating excessive cholesterol, and thus have a protective role. Hypercholesterolemia and chronic low-grade immunological activation are pivotal in the development of atherosclerosis. However, the interconnections between these two factors are not well known. The CD40 system, as measured by the plasma level of soluble CD40 (sCD40), is associated with cholesterol metabolism in hypercholesterolemic patients. When combined, a decreased cholesterol synthesis rate and increased levels of 27-hydroxycholesterol may be a consequence of high levels of cellular cholesterol, and therefore be related to sCD40. However, sCD40 had no significant correlation with total plasma cholesterol. This suggests that the cellular cholesterol synthesis rate and 27-hydroxycholesterol production are more importantly linked with the plasma levels of sCD40 than total cholesterol (PMID: 16081359, 17012138, 11504730, 9144161). 27-hydroxycholesterol is an oxygenated derivative of cholesterol and a major oxysterol in circulation. 27-hydroxycholesterol is the product of the enzyme sterol 27-hydroxylase. The enzyme is critical for degradation of the steroid side-chain and a genetic deficiency of the enzyme leads to reduced formation of bile acids in humans. There is a correlation between 27-hydroxycholesterol and cholesterol in the circulation, and females have lower levels of 27-hydroxycholesterol than males. A strong correlation is observed between circulating levels of 27-hydroxycholesterol and cholesterol, in both healthy subjects and subjects with hypercholesterolemia and documented atherosclerosis. 27-hydroxycholesterol is metabolized by an oxysterol 7a-hydroxylase in the liver, and changes in the activity of this enzyme may lead to accumulation of 27-hydroxycholesterol in the circulation. It has been reported that patients with a genetic deficiency of oxysterol 7a-hydroxylase in the liver had markedly increased levels of 27-hydroxycholesterol in the circulation. Under normal conditions, however, and in the absence of liver or kidney disease, changes in the levels of 27-hydroxycholesterol in the circulation are likely to be caused by changes in the rate of synthesis of these steroids rather than by the rate of metabolism. Three possible explanations for the high concentrations of 27-hydroxycholesterol found in the circulation of the three subjects with atherosclerosis could be: 1) Increased expression of sterol 27-hydroxylase owing to a genetic factor or some other factor completely unrelated to atherosclerosis. 2) The extrahepatic sterol 27-hydroxylase may be up-regulated by circulating factors (e.g. cytokines) that are directly or indirectly related to the development of atherosclerosis. 3) The high amounts of cholesterol accumulating in macrophages in some patients with atherosclerosis may result in increased flux of 27-hydroxycholesterol from the macrophages to the circulation. (25R)-cholest-5-ene-3beta,26-diol is a 26-hydroxycholesterol in which the 25-position has R-configuration. It has a role as an apoptosis inducer, a neuroprotective agent, a human metabolite and a mouse metabolite. It is functionally related to a cholesterol. 27-Hydroxycholesterol is an endogenous metabolite of cholesterol produced by the hydroxylation of the carbon at position 27 by the enzyme sterol 26-hydroxylase, mitochondrial (CYP27A1). Some neoplasms produce excess of 27-hydroxycholesterol (27HC) or inhibit its catabolism, and high cholesterol levels are correlated with elevated levels of 27HC; under these conditions, 27HC may have deleterious selective estrogen receptor modulator (SERM) and liver X receptor (LXR) agonistic activities. As a SERM, 27HC binds to and prevents the activation of estrogen receptors (ERs) in the vasculature. This prevents ER-mediated vasodilation and abrogates the cardiovascular protective effects of estrogen. However, 27HC binds to and activates ERs and LXRs in breast tissue, which stimulates ER-dependent breast cancer cell growth and metastasis. 27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor. 27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor.

   
   

5beta-Coprostanol

(1S,2S,5S,7R,10R,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-ol

C27H48O (388.37049579999996)


Coprosterol or coprostanol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. Coprosterol is the odorous principle of feces. It is formed from the biohydrogenation of cholesterol (cholest-5en-3β-ol) in the gut of most higher animals and birds. This compound has frequently been used as a biomarker for the presence of human faecal matter in the environment. American physician Austin Flint named it stercorin (Wikipedia). The transformation of cholesterol into coprosterol in its passage through the body involves a reduction of the C5:C6 double bond, and a transition from the allocholanic- to the cholanic-ring system. Although it is established that the bacterial flora of the intestine is concerned in the reduction process, the mechanism by which the stereochemical change is brought about is unknown. Current data suggests that cholestenone and coprostanone, and not cholesterol itself, are the immediate precursors of coprosterol which is formed from them in the intestine by bacterial reduction. Coprosterol is also a microbial metabolite, it can be produced by Lactobacillus (PMID: 20338415). Coprosterol or coprostanol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. Coprosterol is the odorous principle of feces. It is formed from the biohydrogenation of cholesterol (cholest-5en-3β-ol) in the gut of most higher animals and birds. This compound has frequently been used as a biomarker for the presence of human faecal matter in the environment. American physician Austin Flint named it stercorin . The transformation of cholesterol into coprosterol in its passage through the body involves a reduction of the C5:C6 double bond, and a transition from the allocholanic- to the cholanic-ring system. Although it is established that the bacterial flora of the intestine is concerned in the reduction process, the mechanism by which the stereochemical change is brought about is unknown. Current data suggests that cholestenone and coprostanone, and not cholesterol itself, are the immediate precursors of coprosterol which is formed from them in the intestine by bacterial reduction. [HMDB] Same as: D01527

   

4a-Methyl-5a-cholesta-8,24-dien-3-one

(2S,6S,7S,11R,14R,15R)-2,6,15-trimethyl-14-[(2R)-6-methylhept-5-en-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-1(10)-en-5-one

C28H44O (396.3391974)


4a-Methyl-5a-cholesta-8,24-dien-3-one is an intermediate in the Cholesterol biosynthesis pathway, in a reaction catalyzed by the enzyme 3-keto-steroid reductase [EC 1.1.1.270]. (MetaCyc Pathway: cholesterol biosynthesis) [HMDB] 4a-Methyl-5a-cholesta-8,24-dien-3-one is an intermediate in the Cholesterol biosynthesis pathway, in a reaction catalyzed by the enzyme 3-keto-steroid reductase [EC 1.1.1.270]. (MetaCyc Pathway: cholesterol biosynthesis).

   

Shidasterone

(2S,3R,5R,9R,10R,13R,14S,17S)-17-[(1R)-1-(5,5-dimethyloxolan-2-yl)-1-hydroxyethyl]-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one

C27H42O6 (462.2981232)


Shidasterone is a phytoecdysteroid, a 2beta-hydroxy steroid, a 3beta-hydroxy steroid, a 14alpha-hydroxy steroid, a 20-hydroxy steroid and a 6-oxo steroid. Shidasterone is a natural product found in Rhaponticum carthamoides and Silene chalcedonica with data available. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

   

Ganoderic acid B

(2R,6R)-6-((3S,5R,7S,10S,13R,14R,17R)-3,7-Dihydroxy-4,4,10,13,14-pentamethyl-11,15-dioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxoheptanoic acid

C30H44O7 (516.3086874)


Ganoderic acid B is a triterpenoid. Ganoderic acid B is a natural product found in Ganoderma sinense and Ganoderma lucidum with data available. See also: Reishi (part of). Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease[1][2][3]. Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease[1][2][3].

   

Viticosterone E

25-acetoxy-2beta,3beta,14alpha,20,22R-pentahydroxy-5beta-cholest-7-en-6-one

C29H46O8 (522.3192516)


   

Spongioside A

(22S)-16beta-[(beta-D-glucopyranosyl)oxy]-22-hydroxycholest-5-en-3beta-yl O-alpha-L-rhamnopyranosyl-(1-2)-O-[alpha-L-rhamnopyranosyl-(1-4)]-beta-D-glucopyranoside

C51H86O21 (1034.5661306)


   

Integristerone A

1beta,2beta,3beta,14alpha,20,22R,25-heptahydroxy-5beta-cholest-7-en-6-one

C27H44O8 (496.3036024)


   

Viperidone

3beta,9alpha-dihydroxy-5alpha-cholest-7-en-6-one

C27H44O3 (416.3290274)


   

Gerardiasterone

2beta,3beta,14alpha,20R,22R,23S,25-heptahydroxy-5beta-cholest-7-en-6-one

C27H44O8 (496.3036024)


   

Spongioside B

(22S)-16beta-[(6-O-acetyl-beta-D-glucopyranosyl)oxy]-22-hydroxy-3beta-[(O-R-L-rhamnopyranosyl-(1-2)-O-[R-L-rhamnopyranosyl-(1-4)]-beta-D-glucopyranosyl)oxy]cholest-5-en-12-one

C53H86O23 (1090.5559606000002)


   

Herbasterol

9-oxo-9,11-seco-5beta-cholestan-2beta,3alpha,6beta,11,19-pentol

C27H48O6 (468.3450708)


   

Isovitexirone

2beta,3beta,11alpha,14alpha,20R,22R-hexahydroxy-5beta-cholest-7,25-dien-6-one

C27H42O7 (478.2930382)


   

Hyousterone D

2alpha,3alpha,9alpha,14beta,25-pentahydroxy-cholest-4,7-dien-6-one

C27H42O6 (462.2981232)


   

Diaulusterol B

2alpha,3alpha,25-trihydroxy-cholest-4,7-dien-6-one

C27H42O4 (430.30829320000004)


   

Blechnoside B

25-O-(beta-D-glucopyranosyl)-3beta,14alpha,22R,25-tetrahydroxy-2-5beta-cholest-7-en-6-one

C33H54O10 (610.3716784)


   

Malacosterone

2beta,3beta,14alpha,16beta,20R,22R,25-heptahydroxy-5beta-cholest-7-en-6-one

C27H44O8 (496.3036024)


   

Arvenin III

Cucurbitacin D 2-O-beta-D-glucoside

C36H54O12 (678.3615084)


   

Taxisterone

2beta,3beta,14alpha,20R,25-pentahydroxy-5beta-cholest-7-en-6-one

C27H44O6 (464.3137724)


   

Zoanthusterone

1beta,2beta,3beta,14alpha,20R,22R-hexahydroxy-5beta-cholest-7-en-6-one

C27H44O7 (480.3086874)


   
   

Herkesterone

2beta,3beta,5beta,14alpha,20R,22R,25-heptahydroxy-cholest-7,9(11)-dien-6-one

C27H42O8 (494.2879532)


   

Cryptogenin

3-Hydroxy-17-(7-hydroxy-6-methyl-3-oxoheptan-2-yl)-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,17-dodecahydrocyclopenta[a]phenanthren-16-one

C27H42O4 (430.30829320000004)


   

venustone

22-O-[(3R)-3-hydroxybutanoyl]-2beta,3beta,14alpha,20,22R,25-hexahydroxy-5beta-cholest-7-en-6-one

C31H50O9 (566.345465)


   

limnantheoside B

3-O-(beta-D-Xylopyranosyl)-2beta,3beta,14alpha,20R,22R-tetrahydroxy-5beta-cholest-7-en-6-one

C32H52O10 (596.3560292)


   

pinnasterol

2beta,3alpha,20R,22S-tetrahydroxy-cholesta-4,7-dien-6-one

C27H42O5 (446.30320820000003)


   

Viperidinone

3beta,9alpha,14alpha-trihydroxy-5alpha-cholest-7-en-6-one

C27H44O4 (432.3239424)


   

nebrosteroid K

Methyl 3beta-hydroxy-cholest-5-en-19-oate

C28H46O3 (430.34467659999996)


   

Saxosterol

cholest-5-en-3beta,16beta,22R-triol

C27H46O3 (418.34467659999996)


   

nebrosteroid J

Methyl 3beta-hydroxy-cholest-5,22E-dien-19-oate

C28H44O3 (428.3290274)


   

Hipposterol

5,6-seco-cholest-7-en-3beta,5beta,6-triol

C27H48O3 (420.36032579999994)


   

Arvenin II

23,24-dihydrocucurbitacin B 2-O-beta-D-glucoside

C38H58O13 (722.3877218)


Arvenin II is a natural product found in Picrorhiza kurrooa, Citrullus colocynthis, and Cucumis melo with data available.

   

fibraurecdyside A

3-O-(beta-D-glucopyranosyl)-2beta,3beta,14alpha,20,22R,25-hexahydroxy-24R-methyl-5beta-cholest-7-en-6-one

C34H56O12 (656.3771576)


   

tenuifolioside B

3beta,14alpha,20R,22R-tetrahydroxy- 5alpha-cholestan-6-one 3-O-beta-D-allopyranoside

C33H56O10 (612.3873276)


   

scabrasterone

2beta,3beta,11alpha,14alpha,20R,25-hexahydroxy-5beta-cholest-7-en-6-one

C27H44O7 (480.3086874)


   

Cholesterol

(1S,2R,5S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol

C27H46O (386.3548466)


A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group. Disclaimer: While authors make an effort to ensure that the content of this record is accurate, the authors make no representations or warranties in relation to the accuracy or completeness of the record. This record do not reflect any viewpoints of the affiliation and organization to which the authors belong. Cholesterol is the major sterol in mammals. It is making up 20-25\\% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins[1][2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist[3]. Cholesterol is the major sterol in mammals. It is making up 20-25\% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins[1][2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist[3].

   

Diaulusterol A

25-(3hydroxybutanoyl)-2alpha,3alpha-dihydroxy-cholest-4,7-dien-6-one

C31H48O6 (516.3450708)


   

limnantheoside A

3-O-(beta-D-Xylopyranosyl)-2beta,3beta,14alpha,20R,22R,25-hexahydroxy-5beta-cholest-7-en-6-one

C32H52O11 (612.3509442)


   

Vitexirone

2beta,3beta,11alpha,14alpha,20,22R-hexahydroxy-5beta-cholest-7,24-dien-6-one

C27H42O7 (478.2930382)


   

Thornasterol A

3beta,6alpha,20S-trihydroxy-5alpha-cholest-9(11)-en-23-one

C27H44O4 (432.3239424)


   

Penasterol

4,4-dimethyl-14-carboxy-cholesta-9(10),24-dien-3beta-ol

C30H48O3 (456.36032579999994)


   

20-hydroxyecdysone 22-phosphate

(22R)-2beta,3beta,14,20,25-pentahydroxy-6-oxo-5beta-cholest-7-en-22-yl dihydrogen phosphate

C27H45O10P (560.2750199999999)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

   

muristerone

(2S,3R,5S,9R,10R,11R,13R,14S,17S)-17-((2R,3R)-2,3-dihydroxy-6-methylheptan-2-yl)-2,3,5,11,14-pentahydroxy-10,13-dimethyl-2,3,4,5,9,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6(10H)-one

C27H44O8 (496.3036024)


Muristerone a is a natural product found in Gomphrena globosa, Gomphrena serrata, and other organisms with data available.

   

ST 28:3;O2

(20R)-3beta-hydroxy-5alpha-cholesta-8,24-diene-4-carbaldehyde

C28H44O2 (412.3341124)


5,6-Epoxyergosterol is a natural product found in Ophiocordyceps sinensis with data available.

   

Ganoderic_acid

(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxo-heptanoic acid

C30H44O7 (516.3086874)


Ganoderic acid A is a triterpenoid. Ganoderic acid A is a natural product found in Ganoderma sinense, Ganoderma lucidum, and Wolfiporia cocos with data available. See also: Reishi (part of). Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS. Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

   

Turkesterone

(2S,3R,5R,9R,10R,11R,13R,14S,17S)-2,3,11,14-tetrahydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one

C27H44O8 (496.3036024)


Turkesterone is a steroid. Turkesterone is a natural product found in Sida spinosa, Cyanotis arachnoidea, and other organisms with data available. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones SubCategory_DNP: : The sterols, Cholestanes

   

Arvenin I

[(E,6R)-6-hydroxy-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-16-hydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-5-oxohept-3-en-2-yl] acetate

C38H56O13 (720.3720726)


Arvenin I is a natural product found in Streptomyces, Helicteres angustifolia, and other organisms with data available.

   

ST 28:3;O6

(2S,3R,5R,9R,10R,13R,14S,17S)-17-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one

C28H44O6 (476.3137724)


Polyporusterone B is a steroid. Polyporusterone B is a natural product found in Polyporus umbellatus with data available. Polyporusterone B is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone B has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis)[1]. Polyporusterone B is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone B has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis)[1].

   

ST 27:1;O2

(3S,5S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-one

C27H46O2 (402.34976159999997)


6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. 6-Ketocholestanol increases the membrane dipole potential[1].

   

coprosterol

5beta-cholestan-3beta-ol

C27H48O (388.37049579999996)


Disclaimer: While authors make an effort to ensure that the content of this record is accurate, the authors make no representations or warranties in relation to the accuracy or completeness of the record. This record do not reflect any viewpoints of the affiliation and organization to which the authors belong.

   

Coprostanone

(5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

C27H46O (386.3548466)


A 3-oxo-5alpha- steroid that is 5alpha-cholestane substituted by an oxo group at position 3. Disclaimer: While authors make an effort to ensure that the content of this record is accurate, the authors make no representations or warranties in relation to the accuracy or completeness of the record. This record do not reflect any viewpoints of the affiliation and organization to which the authors belong. 5α-Cholestan-3-one is an endogenous metabolite.

   

Epicholestanol

5alpha-cholestan-3alpha-ol

C27H48O (388.37049579999996)


A 5alpha-chloestane compound having a 3alpha-hydroxy substituent. Same as: D01527 Disclaimer: While authors make an effort to ensure that the content of this record is accurate, the authors make no representations or warranties in relation to the accuracy or completeness of the record. This record do not reflect any viewpoints of the affiliation and organization to which the authors belong.

   

Cholestenone

Cholestenone (delta 4)

C27H44O (384.3391974)


Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2]. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2].

   

25-OHC

Cholest-5-ene-3beta,25-diol

C27H46O2 (402.34976159999997)


25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

   

Desmesterol

cholest-5,24-dien-3beta-ol

C27H44O (384.3391974)


A cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol. Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis. Desmosterol, as an endogenous metabolite, used to study cholesterol metabolism[1]. Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis. Desmosterol, as an endogenous metabolite, used to study cholesterol metabolism[1].

   

EnP(5,8)

5alpha,8alpha-epidioxy-cholest-6-en-3beta-ol

C27H44O3 (416.3290274)


   

7alpha-hydroxy-4-cholesten-3-one-d7

7alpha-hydroxy-4-cholesten-3-one-d7

C27H37D7O2 (407.37805264599996)


   

5alpha-cholesta-7,24-dien-3beta-ol -d6

5alpha-cholesta-7,24-dien-3beta-ol -d6

C27H38D6O (390.37686046799996)


   

7-dehydrocholesterol-d7

Cholesta-5,7-dien-3beta-ol-d7

C27H37D7O (391.38313764599997)


   

Zymostenol-d7

5alpha-cholest-8(9)-en-3beta-ol-d7

C27H39D7O (393.39878684599995)


   

Cholestanyl glucoside

3-O-(beta-D-glucopyranosyl)-5alpha-cholestan-3beta-ol

C33H58O6 (550.4233168000001)


   

16:0-Glc-Cholesterol

3-O-(6-O-hexadecanoyl-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C49H86O7 (786.6373206000001)


   

18:0-Glc-Cholesterol

3-O-(6-O-octadecanoyl-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C51H90O7 (814.668619)


   

20:0-Glc-Cholesterol

3-O-(6-O-eicosanoyl-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C53H94O7 (842.6999174)


   

22:0-Glc-Cholesterol

3-O-(6-O-docosanoyl-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C55H98O7 (870.7312158)


   

16:1-Glc-Cholesterol

3-O-(6-O-(7Z-hexadecenoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C49H84O7 (784.6216714)


   

16:2-Glc-Cholesterol

3-O-(6-O-(7Z,10Z-hexadecadienoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C49H82O7 (782.6060222000001)


   

16:3-Glc-Cholesterol

3-O-(6-O-(7Z,10Z,13Z-hexadecatrienoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C49H80O7 (780.590373)


   

18:1-Glc-cholesterol

3-O-(6-O-(9Z-octadecenoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C51H88O7 (812.6529697999999)


   

18:2-Glc-cholesterol

3-O-(6-O-(9Z,12Z-octadecadienoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C51H86O7 (810.6373206000001)


   

18:3-Glc-cholesterol

3-O-(6-O-(9Z,12Z,15Z-octadecatrienoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C51H84O7 (808.6216714)


   

20:1-Glc-cholesterol

3-O-(6-O-(11Z-eicosenoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C53H92O7 (840.6842681999999)


   

20:2-Glc-cholesterol

3-O-(6-O-(11Z,14Z-eicosadienoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C53H90O7 (838.668619)


   

20:3-Glc-cholesterol

3-O-(6-O-(11Z,14Z,17Z-eicosatrienoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C53H88O7 (836.6529697999999)


   

22:1-Glc-cholesterol

3-O-(6-O-(13Z-docosenoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C55H96O7 (868.7155665999999)


   

22:2-Glc-cholesterol

3-O-(6-O-(13Z,16Z-docosadienoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C55H94O7 (866.6999174)


   

22:3-Glc-cholesterol

3-O-(6-O-(13Z,16Z,19Z-docosatrienoyl)-beta-D-glucopyranosyl)-cholest-5-en-3beta-ol

C55H92O7 (864.6842681999999)


   

18:2-Glc-Stigmasterol

3-O-(6-O-(9Z,12Z-octadecadienoyl)-beta-D-glucopyranosyl)-stigmast-5,22E-dien-3beta-ol

C53H88O7 (836.6529697999999)


   

25-hydroxy-cholesterol(d3)

cholest-5-en-3beta,25-diol(d3)

C27H43D3O2 (405.368593134)


   

7-oxocholesterol(d7)

7-oxo-cholest-5-en-3beta-ol(d7)

C27H37D7O2 (407.37805264599996)


   

Desmosterol(d6)

cholest-5,24-dien-3beta-ol(d6)

C27H38D6O (390.37686046799996)


   

24,25-epoxy-cholesterol(d6)

24,25-epoxy-cholest-5-en-3beta-ol(d6)

C27H38D6O2 (406.37177546799995)


   

24-hydroxy-cholesterol(d6)

cholest-5-en-3beta,24-diol(d6)

C27H40D6O2 (408.387424668)


   

Cholesterol(d7)

cholest-5-en-3beta-ol(d7)

C27H39D7O (393.39878684599995)


   

Dormatinone

(25S)-3beta,26-dihydroxycholest-5-en-22-one

C27H44O3 (416.3290274)


   

Dormatinol

cholest-5-en-3beta,22S,26S-triol

C27H46O3 (418.34467659999996)


   

25-Azacholesterol

25-Azacholesterol

C26H45NO (387.350096)


   

Fasciculic acid B

5-{[14-(5,6-dihydroxy-6-methylheptan-2-yl)-5,16-dihydroxy-2,6,6,11,15-pentamethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-1(10)-en-4-yl]oxy}-3-hydroxy-3-methyl-5-oxopentanoic acid

C36H60O9 (636.423711)


   

Fasciculic acid C

2-(5-{[4,16-dihydroxy-2,6,6,11,15-pentamethyl-14-(1,5,6-trihydroxy-6-methylheptan-2-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-1(10)-en-5-yl]oxy}-3-hydroxy-3-methyl-5-oxopentanamido)acetic acid

C38H63NO11 (709.4400888)


   

4beta-hydroxy-cholesterol(d7)

cholest-5-en-3beta,4beta-diol(d7)

C27H39D7O2 (409.39370184599994)


   

5,6alpha-epoxy-cholesterol(d7)

5,6alpha-epoxy-5alpha-cholestan-3beta-ol(d7)

C27H39D7O2 (409.39370184599994)


   

7alpha-hydroxy-cholesterol(d7)

cholest-5-en-3beta,7alpha-diol(d7)

C27H39D7O2 (409.39370184599994)


   

6alpha-hydroxycholestanol(d7)

cholestan-3beta,6alpha-diol(d7)

C27H41D7O2 (411.409351046)


   

7beta-hydroxy-cholesterol(d7)

cholest-5-en-3beta,7beta-diol(d7)

C27H39D7O2 (409.39370184599994)


   

5,6beta-epoxy-cholesterol(d7)

5,6beta-epoxy-5beta-cholestan-3beta-ol(d7)

C27H39D7O2 (409.39370184599994)


   

ST 27:1;O2

5alpha,6alpha-epoxy-5alpha-cholestan-3beta-ol

C27H46O2 (402.34976159999997)


D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents D009676 - Noxae > D000963 - Antimetabolites

   

Lanosterin

Lanosta-8,24-dien-3beta-ol

C30H50O (426.386145)


A tetracyclic triterpenoid that is lanosta-8,24-diene substituted by a beta-hydroxy group at the 3beta position. It is the compound from which all steroids are derived. COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

7-kChol

7-oxo-cholest-5-en-3beta-ol

C27H44O2 (400.3341124)


   

ST 27:0;O3

5alpha-Cholestane-3alpha,7alpha,12alpha-triol

C27H48O3 (420.36032579999994)


   

ST 27:3;O

19-norergost-1(10),5,24(28)-trien-3beta-ol

C27H42O (382.3235482)


   

Zymosterol

5alpha-cholesta-8,24-dien-3beta-ol

C27H44O (384.3391974)


COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

7-DHC

cholesta-5,7-dien-3beta-ol

C27H44O (384.3391974)


D018977 - Micronutrients > D014815 - Vitamins > D000072664 - Provitamins 7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3. 7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.

   

ST 27:0;O

5beta-Cholestan-3alpha-ol

C27H48O (388.37049579999996)


5α-Cholestan-3β-ol is a derivitized steroid compound. 5α-Cholestan-3β-ol is a derivitized steroid compound.

   

Epicholesterol

cholest-5-en-3alpha-ol

C27H46O (386.3548466)


   

ST 27:0

5beta-cholestane

C27H48 (372.37558079999997)


   

Lathosterol

(3S,5S,9R,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

C27H46O (386.3548466)


Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis.

   

Lophenol

(3S,4S,5S,9R,10S,13R,14R,17R)-4,10,13-trimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

C28H48O (400.37049579999996)


   

ST 27:2;O

27-nor-(24R)-methylcholest-5,22E-dien-3beta-ol

C27H44O (384.3391974)


   

Zymostenol

5alpha-cholest-8(9)-en-3beta-ol

C27H46O (386.3548466)


   

ST 27:1;O

3beta-hydroxymethyl-A-nor-5alpha-cholest-15-ene

C27H46O (386.3548466)


   

cucurbitacin c

acetic acid [(E,5R)-5-[(3S,8S,9R,10R,13R,14S,16R,17R)-3,16-dihydroxy-9-(hydroxymethyl)-4,4,13,14-tetramethyl-11-oxo-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxohex-2-enyl] ester

C32H48O8 (560.3349008)


   

cucurbitacin J

(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-17-[(2R,5R)-2,5,6-trihydroxy-6-methyl-3-oxoheptan-2-yl]-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthrene-3,11-dione

C30H44O8 (532.3036024)


A cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5-diene substituted by hydroxy groups at positions 2, 16, 20, 24 and 25 and oxo groups at positions 1, 11 and 22.

   

ST 27:3;O4

3beta-Hydroxy-5alpha,6alpha-epoxy-9-oxo-9,10-seco-5-cholest-7-en-11-al

C27H42O4 (430.30829320000004)


   

ST 27:1;O3

(20R,22R)-20,22-Dihydroxycholesterol;(22R)-20alpha,22-Dihydroxycholesterol

C27H46O3 (418.34467659999996)


7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].

   

ST 30:2;O2

4,4-dimethyl-14alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol

C30H50O2 (442.38106)


   

Atheronal-B

3beta,5beta-dihydroxy-b-norcholestan-6beta-carboxaldehyde

C27H46O3 (418.34467659999996)


   

Atheronal-A

3beta,5-oxo-5,6-secocholestan-6-al

C27H46O3 (418.34467659999996)


   

ST 27:0;O2

5alpha-cholest-8(14)-an-3beta,15beta-diol

C27H48O2 (404.36541079999995)


   

Lophanol

4alpha-methyl-5alpha-cholestan-3beta-ol

C28H50O (402.386145)


   

ST 28:0;O

4alpha-methyl-5beta-cholestan-3beta-ol

C28H50O (402.386145)


   

ST 30:2;O

4alpha,14alpha-dimethyl-24-methylene-cholest-9(11)-en-3beta-ol

C30H50O (426.386145)


   

ST 29:2;O

(2R,15R)-14-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

C29H48O (412.37049579999996)


   

22R-hydroxycholesterol(d7)

cholest-5-en-3beta,22R-diol(d7)

C27H39D7O2 (409.39370184599994)


   

22S-hydroxycholesterol(d7)

cholest-5-en-3beta,22S-diol(d7)

C27H39D7O2 (409.39370184599994)


   

25-hydroxy-cholesterol(d6)

cholest-5-en-3beta,25-diol(d6)

C27H40D6O2 (408.387424668)


   

27-hydroxy-cholesterol(d6)

cholest-5-en-3beta,27-diol(d6)

C27H40D6O2 (408.387424668)


   

ST 28:3;O3

(22E,24S)-5alpha,8alpha-epidioxy-24-methyl-cholesta-6,22-dien-3beta-ol

C28H44O3 (428.3290274)


   

ST 27:2;O9

(22R,25R)-2beta,3beta,11alpha,14,20,22,25,26-octahydroxy-5beta-cholest-7-en-6-one

C27H44O9 (512.2985174)


   

Zymosterone

5alpha-cholesta-8,24-dien-3-one

C27H42O (382.3235482)


   

ST 28:2;O2

4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol

C28H46O2 (414.34976159999997)


   

ST 29:3;O2

22S,23S-epoxy-24S-ethyl-5alpha-cholest-8(9),14(15)-dien-3beta-ol

C29H46O2 (426.34976159999997)


   

ST 27:3;O6

(3S,7S,16S,20R,22R,24S)-16,24:20,24-diepoxycholest-5-ene-3,7,22,25-tetraol

C27H42O6 (462.2981232)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

   

ST 29:2;O3

3beta-hydroxy-4alpha-methyl-5alpha-cholest-7-ene-4beta-carboxylic acid

C29H48O3 (444.36032579999994)


   

2-Dhe-22-P

(22R)-3beta,14,20,25-tetrahydroxy-6-oxo-5beta-cholest-7-en-22-yl dihydrogen phosphate

C27H45O9P (544.2801049999999)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

   

2-deoxyecdysone 22-phosphate

(22R)-3beta,14,25-trihydroxy-6-oxo-5beta-cholest-7-en-22-yl dihydrogen phosphate

C27H45O8P (528.28519)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

   

ST 27:2;O7

2beta,3beta,14alpha,15beta,20,22R-hexahydroxy-5beta-cholest-7-en-6-one

C27H44O7 (480.3086874)


   

ST 27:2;O5

3alpha,7alpha,12alpha-trihydroxy-5alpha-23E-cholesten-26-oic acid

C27H44O5 (448.3188574)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

   

3-acetylecdysone 2-phosphate

(22R)-14,22,25-trihydroxy-6-oxo-2beta-(phosphonooxy)-5beta-cholest-7-en-3beta-yl acetate

C29H47O10P (586.2906691999999)


   

lanostane

4,4,14-trimethylcholestane;[5S-[5alpha,8beta,9alpha,10beta,13beta,14alpha,17beta(S*)]]-17-(1,5-dimethylhexyl)hexadecahydro-4,4,10,13,14-pentamethyl-1H-cyclopenta[a]phenanthrene

C30H54 (414.4225284)


   

ST 29:3;O7

2beta,14alpha,22R,25-tetrahydroxy-6-oxo-5beta-cholest-7-en-3beta-yl acetate

C29H46O7 (506.3243366)


   

ST 27:2;O6;Hex

(22R)-2beta,3beta,14,22-tetrahydroxy-6-oxo-5beta-cholest-7-en-25-yl D-glucopyranoside

C33H54O11 (626.3665933999999)


   

ST 28:2;O

27-Nor-4alpha-methyl-5alpha-ergosta-8(14),22-dien-3beta-ol

C28H46O (398.3548466)


   

ST 29:1;O2

4beta-(hydroxymethyl)-4-methyl-5alpha-cholest-7-en-3beta-ol 4beta-(hydroxymethyl)-4alpha-methyl-5alpha-cholest-7-en-3beta-ol

C29H50O2 (430.38106)


   

Lophenone

4alpha-methyl-5alpha-cholest-7-en-3-one

C28H46O (398.3548466)


   

ST 26:0;O5

27-Nor-5b-cholestane-3a,7a,12a,24,25-pentol

C26H46O5 (438.3345066)


   

3a,7a,12a-Trihydroxy-5b-24-oxocholestanoyl-CoA

3a,7a,12a-Trihydroxy-5b-24-oxocholestanoyl-CoA

C48H78N7O21P3S (1213.4184128000002)


   

3a,7a,12a-Trihydroxy-5b-cholest-24-enoyl-CoA

3a,7a,12a-Trihydroxy-5b-cholest-24-enoyl-CoA

C48H78N7O20P3S (1197.4234978)


   

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA

C48H80N7O20P3S (1199.439147)


   

3a,7a-Dihydroxy-5b-24-oxocholestanoyl-CoA

3a,7a-Dihydroxy-5b-24-oxocholestanoyl-CoA

C48H78N7O20P3S (1197.4234978)


   
   
   

ST 30:3;O2

(22R,23R,24R)-7-oxo-22,23-methylene-23,24-dimethylcholest-5-en-3beta-ol

C30H48O2 (440.36541079999995)


   

ST 30:1;O2

4,4-dimethyl-14alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol

C30H52O2 (444.3967092)


   

ST 28:2;O3

5alpha,6alpha-dihydroxy-24R-methyl-cholest-7,22E-dien-3beta-triol

C28H46O3 (430.34467659999996)


   

ST 29:2;O2

(25R)-5alpha,6alpha-epoxy-24R,26R-dimethyl-26,27-cyclo-cholestan-3beta-ol

C29H48O2 (428.36541079999995)


   

ST 28:3;O

4alpha-methyl-5alpha-cholesta-8,24-dien-3-one

C28H44O (396.3391974)


A 3beta-sterol having double bonds in the 5- and 7-positions and a methylene group at position 24.

   

ST 27:0;O5

(25S)-5alpha-cholestan-3beta,6beta,15alpha,16beta,26-pentol

C27H48O5 (452.3501558)


   

8-DHC

cholesta-5,8-dien-3beta-ol

C27H44O (384.3391974)


8-Dehydrocholesterol elevated concentration is one of the diagnostic biochemical hallmarks of classical Smith-Lemli-Opitz syndrome (SLOS).

   

ST 27:1

Cholest-5-ene

C27H46 (370.3599316)


   

ST 28:1;O5

(25S)-24-methylene-5alpha-cholestan-3beta,6alpha,8beta,15beta,26-pentol

C28H48O5 (464.3501558)


   

ST 27:2;O4

9alpha,11alpha-epoxycholest-7-en-3beta,5alpha,6beta-triol

C27H44O4 (432.3239424)


   

ST 27:3;O3

(22Z)-5alpha,8alpha-epidioxy-24-methyl-27-nor-cholesta-6,22-dien-3beta-ol

C27H42O3 (414.3133782)


   

DHCEO

3beta,5alpha-dihydroxycholest-7-en-6-one

C27H44O3 (416.3290274)


   

ST 27:1;O4

(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxycholestan-26-al

C27H46O4 (434.3395916)


   

ST 27:3;O2

3beta-hydroxy-5alpha-cholest-8(9),14(15)-dien-23-one

C27H42O2 (398.3184632)


   

Cystosterol

(20,23-cyclo)-cholest-5-en-3beta-ol

C27H44O (384.3391974)


   

ST 25:2;O

26,27-bisnor-cholesta-5,22E-dien-3beta-ol

C25H40O (356.307899)


   

ST 25:3;O

26,27-dinor-cholest-5-en-23-yn-3beta-ol

C25H38O (354.2922498)


   

ST 26:0;O

19-Nor-5alpha-cholestan-3beta-ol

C26H46O (374.3548466)


   

ST 29:3;O6

9,11alpha-epoxy-6alpha-acetoxy-cholest-7-en-3beta,5alpha,19-triol

C29H46O6 (490.3294216)


   

ST 27:5;O

cholesta-5,7,8(14),22E-tetraen-3-one

C27H38O (378.2922498)


   

ST 23:2;O2

3beta-hydroxy-24-norchol-5-en-23-al

C23H36O2 (344.2715156)


   

ST 26:4;O2

12beta-hydroxy-24-norcholesta-1,4,22E-trien-3-one

C26H38O2 (382.28716479999997)


   

ST 35:5;O9

2alpha,7beta,15beta,18-tetraacetoxy-cholest-5-en-3alpha-ol

C35H54O9 (618.3767634)


   

ST 26:2;O

24-nor-cholest-5,22E-dien-3beta-ol

C26H42O (370.3235482)


   

ST 27:4;O4

16,22-dioxo-25S-methyl-cholest-5,17(20)Z-dien-3beta-ol

C27H40O4 (428.29264400000005)


   

ST 26:1;O

24-nor-cholest-5-en-3beta-ol

C26H44O (372.3391974)


   

Patinosterol

(24S)-26-nor-5alpha-cholest-22E-en-3beta-ol

C27H46O (386.3548466)


   

ST 26:2;O4

24-nor-3beta,6alpha,20S-trihydroxy-5alpha-cholest-9(11)-en-23-one

C26H42O4 (418.30829320000004)


   

ST 27:0;O8

(25S)-5alpha-cholestan-3beta,4beta,6alpha,7beta,8beta,15alpha,16beta,26-octol

C27H48O8 (500.33490079999996)


   

ST 27:0;O6

(25S)-5alpha-cholestan-3beta,6alpha,8beta,15alpha,16beat,26-hexol

C27H48O6 (468.3450708)


   

ST 27:0;O7

(25S)-5alpha-cholestan-3beta,4beta,6alpha,8beta,15alpha,16beta,26-heptol

C27H48O7 (484.33998579999997)


   

5beta-cholestan-3alpha,4alpha,11beta,12beta,21-pentol-3,21-disulfate

5beta-cholestan-3alpha,4alpha,11beta,12beta,21-pentol-3,21-disulfate

C27H48O11S2 (612.2637898)


   

ST 26:2;O3

27-nor-22R-hydroxy-5alpha-cholestan-3,6-dione

C26H42O3 (402.3133782)


   

ST 29:2;O5

11-acetoxy-3beta,6alpha-dihydroxy-9,11-seco-5alpha-cholest-7-en-9-one.

C29H48O5 (476.3501558)


   

Marthasterone

3beta,6alpha-dihydroxy-5alpha-cholesta-9(11),24-dien-23-one

C27H42O3 (414.3133782)


   

ST 27:2;O;Hex

cholest-5,24-dien-3beta-yl beta-D-glucopyranoside

C33H54O6 (546.3920184)


   

ST 27:2;O6

3alpha,6alpha,7alpha,12alpha-Tetrahydroxy-5beta-cholest-24-en-26-oic acid

C27H44O6 (464.3137724)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

   

ST 29:3;O3

3beta-hydroxy-4-methyl-5alpha-cholesta-8,24-diene-4alpha-carboxylic acid

C29H46O3 (442.34467659999996)


   

ST 30:8;O8

(25R)-3,7,11,12,15,23-hexaoxo-lanost-8-ene-26-oic acid

C30H38O8 (526.2566548)


   

ST 30:4;O3

3beta,hydroxy-gorgost-5-en-7,11-dione

C30H46O3 (454.34467659999996)


   

Cholesterol galactoside

cholest-5-en-3beta-yl beta-D-galactopyranoside

C33H56O6 (548.4076676)


   

12:0-Glc-Cholesterol

3-O-(6-O-dodecanoyl-alpha-D-glucopyranosyl)-cholest-5-en-3beta-ol

C45H78O7 (730.5747237999999)


   

Micaceol

4-methylidene-cholest-5-en-3beta-ol

C28H46O (398.3548466)


   

16:0-Gal-Cholesterol

3-O-(6-O-hexadecanoyl-beta-D-galactopyranosyl)-cholest-5-en-3beta-ol

C49H86O7 (786.6373206000001)


   

ST 27:4;O

Cholest-4,20,20-trien-3-one

C27H40O (380.307899)


   

Pentalinonside

14,16-14,21-15,20-triepoxy-14,15-secopregnan-5-en-3-ol 3-O-beta-d-diginopyranoside

C28H42O7 (490.2930382)


   

Endertiin A

3,11-dioxo-5alpha-lanosta-8,24E-dien-26-al

C30H44O3 (452.3290274)


   

Endertiin B

3beta,26-dihydroxy-5alpha-lanosta-11-oxo-8,24E-diene

C30H48O3 (456.36032579999994)


   

Ganodecalone A

26-hydroxy-5alpha-lanosta-3,11-dioxo-8,24E-diene

C30H46O3 (454.34467659999996)


   

Ganodecalone B

27-nor-lanosta-8,23E-dien-3,11,25-trione

C29H42O3 (438.3133782)


   

Arvenin IV

Cucurbitacin R 2-O-beta-D-glucoside

C36H56O12 (680.3771576)


   

ST 30:6;O7

25S-15beta-hydroxy-3,7,11,23-tetraoxolanosta-8-en-26-oic acid.

C30H42O7 (514.2930382)


   

ST 30:6;O8

25S-12beta,15beta-dihydroxy-3,7,11,23-tetraoxolanosta-8-en-26-oic acid.

C30H42O8 (530.2879532000001)


   

ST 30:5;O8

25S-3alpha,12beta,15beta-trihydroxy-7,11,23-trioxolanosta-8-en-26-oic acid.

C30H44O8 (532.3036024)


   

ST 31:7;O10

25S-12beta-acetoxy-15beta-hydroxy-3,7,11,23-tetraoxolanosta-8-en-26-oic acid.

C31H42O10 (574.2777832)


   

ST 30:7;O8

25S-15beta-hydroxy-3,7,11,12,23-pentaoxolanosta-8-en-26-oic acid.

C30H40O8 (528.2723040000001)


   

ST 30:5;O7

3alpha-acetoxy-11beta-hydroxy-24S-methyl-5alpha-furospirostane 18,20R-lactone

C30H44O7 (516.3086874)


   

Ganoweberianone A

26-(3-oxo-lanosta-7,9(11)-dien-24S,25R,26-triol)-25S-15beta-hydroxy-3,7,11,23-tetraoxolanosta-8-en-ate

C60H88O10 (968.6377148)


   

Ganoweberianone B

26-(3-oxo-lanosta-7,9(11)-dien-24S,25R,26-triol)-25S-3alpha,15beta-dihydroxy,7,11,23-trioxolanosta-8-en-ate

C60H90O10 (970.653364)


   

ST 27:3;O8

22-oxo-2beta,3beta,11alpha,14alpha,20,25-hexahydroxy-5beta-cholest-7-en-6-one

C27H42O8 (494.2879532)


   

ST 29:3;O9

22beta-acetoxy-2beta,3beta,11alpha,14alpha,20,25-hexahydroxy-5beta-cholest-7-en-6-one

C29H46O9 (538.3141666)


   

ST 30:3;O8

20,22beta-O-isopropylidene-2beta,3beta,11alpha,14alpha,20,22R,25-heptahydroxy-5beta-cholest-7-en-6-one

C30H48O8 (536.3349008)


   

ST 28:2;O8

2beta,3beta,11alpha,14alpha,20R,22R,25-heptahydroxy-24-methyl-5beta-cholest-7-en-6-one

C28H46O8 (510.3192516)


   

ST 29:4;O9

2beta,3beta,11alpha-14,20,22R-hexahydroxy-26,28R-epoxy-5beta-stigmast-7-ene-6,26-dione

C29H44O9 (536.2985174)


   

Zoanthone A

25-acetoxy-2beta,3beta,11alpha,14alpha,20R,22R-hexahydroxy-5beta-cholest-7-en-6-one

C29H46O9 (538.3141666)


   

Brainesteroside A

3-O-(beta-D-glucopyranosyl)-2beta,3beta,20,22R-tetrahydroxy-14alpha,15alpha-epoxy-5beta-cholest-7-en-6-one

C33H52O11 (624.3509442)


   

Brainesteroside B

3-O-(beta-D-glucopyranosyl)-2beta,3beta,20,22R-tetrahydroxy-5beta-cholest-7,14-dien-6-one

C33H52O10 (608.3560292)


   

Brainesteroside C

3-O-(beta-D-glucopyranosyl)-2beta,3beta,6,20,22R-pentahydroxy-cholest-5,8,14-trien-7-one

C33H50O11 (622.335295)


   

Brainesteroside D

3-O-(beta-D-glucopyranosyl)-2beta,3beta,14alpha,22R-tetrahydroxy-5beta-cholest-7-ene-6-one

C33H54O10 (610.3716784)


   

Brainesteroside E

3-O-(beta-D-glucopyranosyl)-2beta,3beta,14alpha,20R,22R-pentahydroxy-5alpha-cholest-7-ene-6-one

C33H54O11 (626.3665933999999)


   

Bombycosterol

Cholesta-7,14-diene-3beta,5alpha,6alpha,20,25-pentaol

C27H44O5 (448.3188574)


   

Lesterone

2alpha,3alpha,11beta,14alpha,20R,22R,25-heptahydroxy-5beta-cholest-7-en-6-one

C27H44O8 (496.3036024)


   

Ecdysone 22-palmitate

22-O-hexadecanoyl-2beta,3beta,14alpha,22R,25-pentahydroxy-5beta-cholest-7-en-6-one

C43H74O7 (702.5434253999999)


   

Ecdysone 22-stearate

22-O-octadecanoyl-2beta,3beta,14alpha,22R,25-pentahydroxy-5beta-cholest-7-en-6-one

C45H78O7 (730.5747237999999)


   

Ecdysone 22-palmitoleate

22-O-(9Z-hexadecenoyl)-2beta,3beta,14alpha,22R,25-pentahydroxy-5beta-cholest-7-en-6-one

C43H72O7 (700.5277762000001)


   

Ecdysone 22-oleate

22-O-(9Z-octadecenoyl)-2beta,3beta,14alpha,22R,25-pentahydroxy-5beta-cholest-7-en-6-one

C45H76O7 (728.5590746)


   

Ecdysone 22-linoleate

22-O-(9Z,12Z-octadecdienoyl)-2beta,3beta,14alpha,22R,25-pentahydroxy-5beta-cholest-7-en-6-one

C45H74O7 (726.5434253999999)


   

Cholesteryl xyloside

cholest-5-en-3beta-yl beta-D-xylopyranoside

C32H54O5 (518.3971034)


   

ST 31:5;O8

(3S,5S,16S,20R,22R,24S)-16,24:20,24-diepoxycholest-6-ene-3,5,22,25-tetrol 3,22-diacetate

C31H46O8 (546.3192516)


   
   

ST 31:4;O8

24alpha-Methoxydihydrocucurbitacin D

C31H48O8 (548.3349008)


   

ST 32:6;O9

7beta-Hydroxy-3-epi-isocucurbitacin B

C32H46O9 (574.3141666)


   
   

ST 27:0;O4

(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol

C27H48O4 (436.3552408)


   
   

ST 29:4;O6

7beta-acetoxy,3beta-hydroxy-24-oxo-25,26,27-trinor--9beta,19-cyclo-lanostan-29-oic acid

C29H44O6 (488.3137724)


   

Calonysterone

2beta,3beta,6,20R,22R,25-hexahydroxycholesta-5,8(9),14-trien-7-one

C27H40O7 (476.277389)


   

ST 27:3;O7

22-oxo-2beta,3beta,11alpha,14alpha,20-pentahydroxy-5beta-cholest-7-en-6-one

C27H42O7 (478.2930382)


   

ST 27:3;O5

2beta,3beta,20R,22R-tetrahydroxy-cholesta-7,9(11)-dien-6-one

C27H42O5 (446.30320820000003)


   

Calibagenin

cholest-5-en-3beta,16beta,22S-triol

C27H46O3 (418.34467659999996)


   

Ehrensteroid B

11alpha-acetoxy-23-methylcholesta-22(E)-en-3beta,5alpha,6beta-triol

C30H50O5 (490.365805)


   

Lobophysterol A

25-hydroperoxy,11alpha-acetoxy-cholest-23E-en-3beta,5alpha,6beta-triol

C29H48O7 (508.33998579999997)


   

ST 25:2;O2

3beta-hydroxy-26,27-bisnorcholest-5-en-24-one

C25H40O2 (372.302814)


   

Cyathsterone D

(20R,22R,23R,25R)-2beta,3beta,14alpha,20,22-26-hexahydroxy-6-oxo-23-methyl-cholest-7-ene

C28H46O7 (494.3243366)


   

Cyathsterone A

(22R,25R,28R,32R)-2beta,3beta,14alpha,20R-33-pentahydroxy-25-ethyl-28beta-(1-hydroxybutan-2-yl)-6-oxo-5beta-cholest-7-ene-27,29-dioxocan

C33H54O8 (578.3818484)


   

Menellsteroid E

1beta,3beta,5alpha,11beta-tetrahydroxycholestan-6-one

C27H46O5 (450.3345066)


   

Menellsteroid F

Cholest-24-ene-3beta,5alpha,6beta,11beta-tetraol

C27H46O4 (434.3395916)


   

Menellsteroid H

24-nor-cholest-22(E)-ene-3beta,5α=alpha,6beta,11beta-tetraol

C26H44O4 (420.3239424)


   

ST 31:5;O7

(3S,16S,20R,22R,24S)-16,24:20,24-diepoxycholest-5-ene-3,22,25-triol 3,22-diacetate

C31H46O7 (530.3243365999999)


   

ST 29:4;O7

(3S,5S,16S,20R,22R,24S)-16,24:20,24-diepoxycholest-6-ene-3,5,22,25-tetrol 22-acetate

C29H44O7 (504.3086874)


   

Verrucorosterone

3beta-acetoxy-22S,25-trihydroxy-cholest-5,22E-dien-24-one

C29H44O5 (472.3188574)


   

Subergosterone A

9alpha-hydroxy-5alpha-cholest-1,22E-dien-3-one

C27H42O2 (398.3184632)


   

Ximaosteroid F

20R,22R-dihydroxy-5alpha-campesta-1,4-dien-3-one

C27H42O3 (414.3133782)


   

ST 30:3;O5

11-acetoxy-3beta,6alpha-dihydroxy-24-methylene-9,11-seco-5alpha-cholesta-7,22E-dien-9-one.

C30H48O5 (488.3501558)


   

ST 29:2;O6

22S-acetoxy-6beta,19-epoxycholestan-3alpha,5alpha,25-triol

C29H48O6 (492.3450708)


   

Cucurbitacin C1

23(S)-3beta,19,20beta-trihydroxy-16alpha,23alpha-epoxy-cucurbit-5,24-dien-11-one

C30H44O6 (500.3137724)


   

Cucurbitacin C2

24(S)-3beta,16alpha,19,20beta,24,25-hexahydroxycucurbit-5-en-11,22-dione

C30H48O8 (536.3349008)


   

Cucurbitacin C3

24(R)-ethoxy-25-acetyloxy-3beta,16alpha,19,20beta-tetrahydroxycucurbit-5-en-11,22-dione

C34H54O9 (606.3767634)


   

Cucurbitacin C4

24(R)-methoxy-3beta,16alpha,19,20beta,25-pentahydroxycucurbit-5-en-11,22-dione

C31H50O8 (550.35055)


   

Cucurbitacin C5

3beta,16alpha,19,20beta,25-pentahydroxycucurbit-5-en-11,22-dione

C30H48O7 (520.3399858)


   

Cucurbitacin C6

25-acetyloxy-3beta,16alpha,20beta-trihydroxy-5beta,19beta-epoxy-cucurbit-6-en-11,22-dione

C32H48O8 (560.3349008)


   

Cucurbitacin C7

25-acetyloxy-3beta,16alpha,20beta-trihydroxy-5beta,19beta-epoxy-cucurbit-6,23-dien-11,22-dione

C32H46O8 (558.3192516)


   

ST 32:4;O8

25-acetyloxy-3beta,16alpha,19,20beta-tetrahydroxycucurbit-5-en-11,22-dione

C32H50O8 (562.35055)


   

ST 30:4;O7

3beta,16alpha,19,20beta,25-pentahydroxycucurbit-5,23-dien-11,22-dione

C30H46O7 (518.3243365999999)


   

ST 27:1;O6

26-nor-24-methyl-5alpha-cholest-22E-en-3beta,4,6alpha,8beta,15beta,26-hexol

C27H46O6 (466.3294216)


   

ST 27:1;O5

(3alpha,5beta,7alpha,12alpha,25S)-3,7,12-trihydroxycholestan-26-oic acid

C27H46O5 (450.3345066)


   

Sinulasterol G

Cholest-5,22E-dien-3beta,11alpha-diol

C27H44O2 (400.3341124)


   

Lathosterone

5alpha-Cholest-7-en-3-one

C27H44O (384.3391974)


   

Nannosterol A

3beta,15beta,24R,25-tetrahydroxy-5-alpha-cholestan-7-one

C27H46O5 (450.3345066)


   

Nannosterol B

3beta,15beta,18,24R,25-pentahydroxy-5-alpha-cholestan-7-one

C27H46O6 (466.3294216)


   

ST 27:5;O7

2beta,3beta,6,20R,25-pentahydroxycholesta-5,8(14),9(11)-trien-7,22-dione

C27H38O7 (474.2617398)


   

ST 27:3;O9

6-oxo-2beta,3beta,14alpha,20R,22R,25-hexahydroxy-5beta-cholest-7-en-26-oic acid

C27H42O9 (510.28286820000005)


   

Abutasterone

2beta,3beta,14alpha,20,22R,24S,25-heptahydroxy-5beta-cholest-7-en-6-one

C27H44O8 (496.3036024)


   

silenoside E

3-O-(beta-D-glucopyranosyl)-3beta,14alpha,22R,25-tetrahydroxy-2-5beta-cholest-7-en-6-one

C33H54O10 (610.3716784)


   

Bombycosterol 3-phosphate

5alpha,6alpha,20,25-tetrahydroxy-cholesta-7,14-diene-3beta-yl-dihydrogenphosphate

C27H45O8P (528.28519)


   

2,22-dideoxy-20-hydroxyecdysone 3-phosphate

6alpha,14alpha,20,25-tetrahydroxy-5alpha-cholesta-7-en-3beta-yl-dihydrogenphosphate

C27H45O8P (528.28519)


   

ST 28:4;O6

2beta,3beta,14alpha,22S-tetrahydroxy-24-methylene-20,25-epoxy-5beta-cholesta-7-en-6-one

C28H42O6 (474.2981232)


   

ST 29:3;O8

2beta,3beta,14alpha,20beta-Tetrahydroxy-22alpha-(2-hydroxyacetiloxy)-5beta-cholest-7-en-6-one

C29H46O8 (522.3192516)


   

Hyousterone A

2alpha,3alpha,14alpha,25-tetrahydroxy-cholest-4,7-dien-6-one

C27H42O5 (446.30320820000003)


   

Hyousterone C

2alpha,3alpha,9alpha,14alpha,25-pentahydroxy-cholest-4,7-dien-6-one

C27H42O6 (462.2981232)


   

Tenuifolioside A

3beta,14alpha,20R,22R-tetrahydroxy- 5alpha-cholestan-6-one 3-O-beta-D-glucpyranoside

C33H56O10 (612.3873276)


   

Limnantheoside C

3-O-(beta-D-glucopyranosyl-[1-3]-beta-D-xylopyranosyl)-2beta,3beta,14alpha,20R,22R,25-hexahydroxy-5beta-cholest-7-en-6-one

C38H62O16 (774.4037652)


   

Kaladasterone

2beta,3beta,5beta,14alpha,20R,22R-hexahydroxy-cholest-7,9(11)-dien-6-one

C27H42O7 (478.2930382)


   

ST 27:4;O7

2beta,3beta,14alpha,20R,25,pentahydroxy-cholesta-7,22-dien-6,24-dione

C27H40O7 (476.277389)


   

Palythone A

4alpha,14alpha,20R,22R,25-pentahydroxy-5beta-cholesta-7-en-6-one

C27H44O6 (464.3137724)


   

Uniflorsterone

2beta,3beta,11alpha,14alpha,20R,23S-hexahydroxy-5beta-cholesta-7-en-6-one

C27H44O7 (480.3086874)


   

Compound 17

5alpha-Hydroxy-6beta-[4-(2-Aminoethyl)imidazol-1-yl]cholestan-3beta-ol

C32H55N3O2 (513.429405)


   

25H-OCDO

cholestane-6-oxo-3beta,5alpha,25-triol

C27H46O4 (434.3395916)


   

27H-OCDO

cholestane-6-oxo-3beta,5alpha,27-triol

C27H46O4 (434.3395916)


   

25H-CT

Cholestan-3beta,5alpha,6beta,25-tetraol

C27H48O4 (436.3552408)


   

27H-CT

Cholestan-3beta,5alpha,6beta,27-tetraol

C27H48O4 (436.3552408)


   

ST 34:7;O8

25-O-benzoyl-2beta,3beta,14alpha,20,22R-pentahydroxy-5beta-cholest-7-en-6-one

C34H48O8 (584.3349008)


   

Superecdysone C

(20S,22R)-3beta-(2R-hydroxypropionyl)-14alpha,22R,25-trihydroxy-5beta-cholest-7-en-6-one

C30H48O7 (520.3399858)


   

Superecdysone D

(20S,22R)-22R-(2R-hydroxypropionyl)-3beta,14alpha,22R,25-trihydroxy-5beta-cholest-7-en-6-one

C30H48O7 (520.3399858)


   

Superecdysone A

(20S,22R)-22,25-epoxy-3beta,14alpha-dihydroxy-5beta-cholest-7-en-6-one

C27H42O4 (430.30829320000004)


   

Superecdysone B

(20R,22R)-22,25-epoxy-3beta,14alpha,20-trihydroxy-5beta-cholest-7-en-6-one

C27H42O5 (446.30320820000003)


   

Superecdysone E

(20S,22R)-3beta-(2R-hydroxypropionyl)-20,22-acetonide-14alpha,25-dihydroxy-5beta-cholest-7-en-6-one

C33H52O8 (576.3661992)


   

Superecdysone F

(20S,22R)-3beta,6,22,25-tetrahydroxycholest-5,8,14-trien-7-one

C27H40O5 (444.28755900000004)


   

ST 36:8;O9

2-O-Cinnamoyloxy-2beta,3beta,11alpha,14alpha,20,22R,25-heptahydroxy-5beta-cholest-7-en-6-one

C36H50O9 (626.345465)


   

2,22-dideoxy-23-hydroxyecdysone phosphate

14alpha,23S,25-trihydroxy-6-oxo-5beta-cholest-7-en-3beta-yl dihydrogen phosphate

C27H45O8P (528.28519)


   

26-Hydroxycholesterol

Cholest-5-ene-3beta,27-diol

C27H46O2 (402.34976159999997)


An oxysterol that is cholesterol substituted at position 26 by a hydroxy group.

   

Cuc B

(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

C32H46O8 (558.3192516)


Cucurbitacin B is a cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated. It is a cucurbitacin, a secondary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It derives from a hydride of a lanostane. Cucurbitacin B is a natural product found in Begonia plebeja, Trichosanthes miyagii, and other organisms with data available. A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity[1][2][3][4][5]. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity[1][2][3][4][5].

   

Cucurbitacin_D

(2S,4R,23E)-2,16,20,25-tetrahydroxy-9beta,10,14-trimethyl-4,9-cyclo-9,10-seco-16alpha-cholesta-5,23-diene-1,11,22-trione

C30H44O7 (516.3086874)


Cucurbitacin D is a cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23. It is a cucurbitacin, a secondary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It derives from a hydride of a lanostane. Cucurbitacin D is a natural product found in Elaeocarpus chinensis, Elaeocarpus hainanensis, and other organisms with data available. A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23. Cucurbitacin D is an active component in Trichosanthes kirilowii, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity[1]. Cucurbitacin D is an active component in Trichosanthes kirilowii, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity[1].

   

25-Hydroxycholesterol

Cholest-5-ene-3beta,25-diol

C27H46O2 (402.34976159999997)


25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

   

FF-MAS

4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol

C29H46O (410.3548466)