Bufalin (BioDeep_00000000018)

   

PANOMIX_OTCML-2023 Chemicals and Drugs Toxin


代谢物信息卡片


5-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one

化学式: C24H34O4 (386.24569640000004)
中文名称: 蟾毒灵
谱图信息: 最多检出来源 Viridiplantae(plant) 0.64%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Bufalin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/bufalin (retrieved 2024-09-08) (BioDeep RN: BioDeep_00000000018). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C1([H])4)(C)(C5)C([H])(CC(O)C5)CCC(C(C(C)(CC4)2)(O)CCC2C(C=3)=COC(=O)C3)1[H]
InChI: InChI=1S/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19+,20-,22+,23-,24+/m1/s1

描述信息

Bufalin is a cardiotonic steroid toxin[1] originally isolated from Chinese toad venom, which is a component of some traditional Chinese medicines.[2][3]

Bufalin has in vitro antitumor effects against various malignant cell lines, including hepatocellular[4] and lung carcinoma.[5] However, as with other bufadienolides, its potential use is hampered by its cardiotoxicity.[6]

Bufalin is a 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo. It has a role as an antineoplastic agent, a cardiotonic drug, an anti-inflammatory agent and an animal metabolite. It is a 3beta-hydroxy steroid and a 14beta-hydroxy steroid. It is functionally related to a bufanolide.
Bufalin is a natural product found in Cunninghamella blakesleeana, Bufo gargarizans, and other organisms with data available.

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in cancer cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.

A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo.


Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively[1][2]. Anti-cancer activity[2].
Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively[1][2]. Anti-cancer activity[2].

同义名列表

25 个代谢物同义名

5-(3,14-Dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pyran-2-one; Bufalin; 5-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one; 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one; (3beta,5beta,10alpha,17alpha)-3,14-dihydroxybufa-20,22-dienolide; Bufa-20,22-dienolide, 3,14-dihydroxy-, (3.beta.,5.beta.)-; Bufalin: Bufa-20,22-dienolide, 3,14-dihydroxy-, (3b,5b)-,; Bufa-20,22-dienolide, 3,14-dihydroxy-, (3-beta,5-beta)-; Bufa-20,22-dienolide, 3,14-dihydroxy-, (3beta,5beta)-; 3beta,14beta-dihydroxy-5beta-bufa-20,22-dienolide; 5-beta-BUFA-20,22-DIENOLIDE, 3-beta,14-DIHYDROXY-; (3beta,5beta)-3,14-dihydroxybufa-20,22-dienolide; Bufa-20,22-dienolide, 3,14-dihydroxy-, (3b,5b)-; 5beta-Bufa-20,22-dienolide, 3beta,14-dihydroxy-; 3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide; 3,14-Dihydroxy-bufa-20,22-dienolide; bufalin, (3alpha,5beta)-isomer; QEEBRPGZBVVINN-BMPKRDENSA-N; BUFALIN [WHO-DD]; BUFALIN [MI]; HSCI1_000110; SMP2_000290; ST 24:4;O4; Chan su; BUF



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

106 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Donghao Tang, Haijing Wang, Wanli Deng, Jie Wang, Dongxiao Shen, Lu Wang, Jiahao Lu, Yuejiao Feng, Saiya Cao, Wei Li, Peihao Yin, Ke Xu, Jinbao Chen. Mechanism of bufalin inhibition of colon cancer liver metastasis by regulating M2-type polarization of Kupffer cells induced by highly metastatic colon cancer cells. Apoptosis : an international journal on programmed cell death. 2024 Jun; 29(5-6):635-648. doi: 10.1007/s10495-023-01930-5. [PMID: 38393643]
  • Xuemei Zhang, Xiaona Lu, Jia Shi, Yuyao Li, Yue Li, Ru Tao, Lingying Huang, Yifei Tang, Xiaojun Zhu, Man Li, Yueqiu Gao, Hai Feng, Zhuo Yu. Bufalin suppresses hepatocellular carcinogenesis by targeting M2 macrophage-governed Wnt1/β-catenin signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155395. doi: 10.1016/j.phymed.2024.155395. [PMID: 38340578]
  • Ran Guo, Fang Lu, Jiang Lin, Caixia Fu, Mengxiao Liu, Shuohui Yang. Multi-b-value DWI to evaluate the synergistic antiproliferation and anti-heterogeneity effects of bufalin plus sorafenib in an orthotopic HCC model. European radiology experimental. 2024 Mar; 8(1):43. doi: 10.1186/s41747-024-00448-y. [PMID: 38467904]
  • Jing-Zhuang Zhao, Li-Ming Xu, Lin-Fang Li, Guang-Ming Ren, Yi-Zhi Shao, Qi Liu, Tong-Yan Lu. Traditional Chinese medicine bufalin inhibits infectious hematopoietic necrosis virus infection in vitro and in vivo. Microbiology spectrum. 2024 Jan; ?(?):e0501622. doi: 10.1128/spectrum.05016-22. [PMID: 38289115]
  • Zejie Su, Man Luo, Zhi Lian Chen, Hai Lan. Comparison of the Ways in Which Nitidine Chloride and Bufalin Induce Programmed Cell Death in Hematological Tumor Cells. Applied biochemistry and biotechnology. 2023 Dec; 195(12):7755-7765. doi: 10.1007/s12010-023-04468-z. [PMID: 37086379]
  • Wei Zhang, Yibao Fan, Jinze Zhang, Dan Shi, Jiahui Yuan, Milad Ashrafizadeh, Wei Li, Man Hu, A M Abd El-Aty, Ahmet Hacimuftuoglu, Michael Linnebacher, Yongxian Cheng, Weiguang Li, Shuo Fang, Peng Gong, Xianbin Zhang. Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2023 Aug; 71(?):101005. doi: 10.1016/j.drup.2023.101005. [PMID: 37647746]
  • Zijun Qian, Xiaoting Tian, Yayou Miao, Xin Xu, Xuehua Cheng, Mengyi Wu, Yongchun Yu. Bufalin inhibits the proliferation of lung cancer cells by suppressing Hippo-YAP pathway. Cellular signalling. 2023 Jun; 109(?):110746. doi: 10.1016/j.cellsig.2023.110746. [PMID: 37286119]
  • Linxuan Miao, Ying Liu, Nasra Mohamoud Ali, Yan Dong, Bin Zhang, Xiaonan Cui. Bufalin serves as a pharmaceutic that mitigates drug resistance. Drug metabolism reviews. 2023 Apr; ?(?):1-10. doi: 10.1080/03602532.2023.2206065. [PMID: 37114332]
  • Ya-Dong Zheng, Zhen He, Zhu-Cheng Su, Hui Wang, Xiao-Hong Jiang, Xu Fang, Sheng-Lin Lu, Yuan Li. Bufalin induces apoptosis and autophagy via the Ca2+/CaMKKβ/AMPK/Beclin1 signaling pathway in osteosarcoma cells. Cell biology international. 2023 Mar; ?(?):. doi: 10.1002/cbin.12021. [PMID: 36987947]
  • Haijing Wang, Jinbao Chen, Sen Li, Jiahua Yang, Donghao Tang, Wentao Wu, Kun Yu, Yijun Cao, Ke Xu, Peihao Yin, Yi Chen, Wei Li. Bufalin reverses cancer-associated fibroblast-mediated colorectal cancer metastasis by inhibiting the STAT3 signaling pathway. Apoptosis : an international journal on programmed cell death. 2023 Jan; ?(?):. doi: 10.1007/s10495-023-01819-3. [PMID: 36705874]
  • Chang-Jing Huang, Chen-Yue Zhang, Ying-Ke Zhao, Dan Wang, Liping Zhuang, Ling Qian, Lin Xie, Ying Zhu, Zhi-Qiang Meng. Bufalin Inhibits Tumorigenesis and SREBP-1-Mediated Lipogenesis in Hepatocellular Carcinoma via Modulating the ATP1A1/CA2 Axis. The American journal of Chinese medicine. 2023 Jan; ?(?):1-25. doi: 10.1142/s0192415x23500246. [PMID: 36655687]
  • Ling Ding, Yuning Yang, Qin Lu, Dongfeng Qu, Parthasarathy Chandrakesan, Hailan Feng, Hong Chen, Xuzheng Chen, Zhuhui Liao, Jian Du, Zhiyun Cao, Nathaniel Weygant. Bufalin Inhibits Tumorigenesis, Stemness, and Epithelial-Mesenchymal Transition in Colorectal Cancer through a C-Kit/Slug Signaling Axis. International journal of molecular sciences. 2022 Nov; 23(21):. doi: 10.3390/ijms232113354. [PMID: 36362141]
  • Zeting Yuan, Chaolian Liu, Yuji Sun, Yue Li, Honglei Wu, Shuli Ma, Jing Shang, Yueping Zhan, Peihao Yin, Feng Gao. Bufalin exacerbates Photodynamic therapy of colorectal cancer by targeting SRC-3/HIF-1α pathway. International journal of pharmaceutics. 2022 Aug; 624(?):122018. doi: 10.1016/j.ijpharm.2022.122018. [PMID: 35839982]
  • Zhuo Yu, Yuyao Li, Yue Li, Jinghao Zhang, Man Li, Longshan Ji, Yifei Tang, Yanxi Zheng, Jianguo Sheng, Qiucheng Han, Fu Li, Jianfeng Guo, Lingtai Wang, Xuehua Sun, Yueqiu Gao, Hai Feng. Bufalin stimulates antitumor immune response by driving tumor-infiltrating macrophage toward M1 phenotype in hepatocellular carcinoma. Journal for immunotherapy of cancer. 2022 05; 10(5):. doi: 10.1136/jitc-2021-004297. [PMID: 35618286]
  • Dongzhu Tu, Jing Ning, Liwei Zou, Ping Wang, Yani Zhang, Xiangge Tian, Feng Zhang, Jiang Zheng, Guangbo Ge. Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A. Journal of medicinal chemistry. 2022 03; 65(5):4018-4029. doi: 10.1021/acs.jmedchem.1c01875. [PMID: 35094507]
  • Yujia Liu, Xiaoyu Lu, Zhenhai Zhang, Shulong Jiang, Huixia Lv. mPEG-Cholic acid/TPGS mixed micelles for combined delivery of paclitaxel and bufalin to treat hepatocellular carcinoma. Pharmaceutical development and technology. 2022 Feb; 27(2):215-227. doi: 10.1080/10837450.2022.2037140. [PMID: 35105263]
  • Chunyan Gu, Yajun Wang, Lulin Zhang, Li Qiao, Shanliang Sun, Miaomiao Shao, Xiaozhu Tang, Pinggang Ding, Chao Tang, Yuhao Cao, Yanyan Zhou, Mengjie Guo, Rongfang Wei, Nianguang Li, Yibei Xiao, Jinao Duan, Ye Yang. AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma. Journal of experimental & clinical cancer research : CR. 2022 Jan; 41(1):11. doi: 10.1186/s13046-021-02220-1. [PMID: 34991674]
  • Lei Dou, Dan Zou, Feiran Song, Yuxin Jin, Yin Li, Yi Zhang. Bufalin suppresses ovarian cancer cell proliferation via EGFR pathway. Chinese medical journal. 2021 Dec; 135(4):456-461. doi: 10.1097/cm9.0000000000001879. [PMID: 34935692]
  • Rao Fu, Fangjing Yu, Weiqi Wu, Juan Liu, Jia Li, Fangyue Guo, Lei Xu, Feng Wang, Xiaonan Cui. Bufalin enhances the killing efficacy of NK cells against hepatocellular carcinoma by inhibiting MICA shedding. International immunopharmacology. 2021 Dec; 101(Pt B):108195. doi: 10.1016/j.intimp.2021.108195. [PMID: 34678691]
  • Kai Fang, Yueping Zhan, Ruiqiu Zhu, Yuqian Wang, Chengqi Wu, Min Sun, Yanyan Qiu, Zeting Yuan, Xin Liang, Peihao Yin, Ke Xu. Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway. Journal of translational medicine. 2021 09; 19(1):383. doi: 10.1186/s12967-021-03058-z. [PMID: 34496870]
  • Hao Gou, Ruo-Chen Huang, Fu-Lei Zhang, Yong-Hua Su. Design of dual targeting immunomicelles loaded with bufalin and study of their anti-tumor effect on liver cancer. Journal of integrative medicine. 2021 09; 19(5):408-417. doi: 10.1016/j.joim.2021.05.001. [PMID: 34130942]
  • Jinbao Chen, Haijing Wang, Linlin Jia, Jing He, Yue Li, Huan Liu, Ruixin Wu, Yanyan Qiu, Yueping Zhan, Zeting Yuan, Yijun Cao, Wei Li, Ke Xu, Peihao Yin. Bufalin targets the SRC-3/MIF pathway in chemoresistant cells to regulate M2 macrophage polarization in colorectal cancer. Cancer letters. 2021 08; 513(?):63-74. doi: 10.1016/j.canlet.2021.05.008. [PMID: 34000344]
  • Jing Jin, Ziping Yao, Huijuan Qin, Kunling Wang, Xiaoyi Xin. Bufalin inhibits the malignant development of non-small cell lung cancer by mediating the circ_0046264/miR-522-3p axis. Biotechnology letters. 2021 Jun; 43(6):1229-1240. doi: 10.1007/s10529-021-03081-6. [PMID: 33534015]
  • Dan Zou, Jincheng Song, Mingming Deng, Yanju Ma, Chunjiao Yang, Jiaqing Liu, Song Wang, Zhenpeng Wen, Yu Tang, Xiujuan Qu, Ye Zhang. Bufalin inhibits peritoneal dissemination of gastric cancer through endothelial nitric oxide synthase-mitogen-activated protein kinases signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 05; 35(5):e21601. doi: 10.1096/fj.202002780r. [PMID: 33913201]
  • Ying Xu, Lei Tang, Peng Chen, Mei Chen, Miaomiao Zheng, Feng Shi, Yanchun Wang. Tumor-Targeted Delivery of Bufalin-Loaded Modified Albumin-Polymer Hybrid for Enhanced Antitumor Therapy and Attenuated Hemolysis Toxicity and Cardiotoxicity. AAPS PharmSciTech. 2021 Apr; 22(4):137. doi: 10.1208/s12249-021-02000-2. [PMID: 33880681]
  • Jincheng Song, Dan Zou, Xiaoxuan Zhao, Yang Chen, Fei Lv, Song Wang, Dan Sui, Qiuyue Han, Chunjiao Yang, Ximing Wang, Bofang Liu, Mingming Deng, Ye Zhang. Bufalin inhibits human diffuse large B-cell lymphoma tumorigenesis by inducing cell death through the Ca2+/NFATC1/cMYC pathway. Carcinogenesis. 2021 02; 42(2):303-314. doi: 10.1093/carcin/bgaa108. [PMID: 33124657]
  • Lina Gao, Lei Zhang, Fengjun He, Jing Chen, Meng Zhao, Simin Li, Hao Wu, Yumeng Liu, Yinan Zhang, Qineng Ping, Lihong Hu, Hongzhi Qiao. Surfactant Assisted Rapid-Release Liposomal Strategies Enhance the Antitumor Efficiency of Bufalin Derivative and Reduce Cardiotoxicity. International journal of nanomedicine. 2021; 16(?):3581-3598. doi: 10.2147/ijn.s313153. [PMID: 34079251]
  • Zhuo Yu, Hai Feng, Yunhui Zhuo, Man Li, Xiaojun Zhu, Lingying Huang, Xin Zhang, Zhenhua Zhou, Chao Zheng, Yun Jiang, Fan Le, Dae-Yeul Yu, Alfred Szelok Cheng, Xuehua Sun, Yueqiu Gao. Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation. Cellular oncology (Dordrecht). 2020 Dec; 43(6):1129-1145. doi: 10.1007/s13402-020-00546-0. [PMID: 32623699]
  • Yan Liu, Wei Xu, Zhao-He Huang, Jun Guo, Ren-Wang Jiang. An Efficient Strategy for the Chemo-Enzymatic Synthesis of Bufalin Glycosides with Improved Water Solubility and Inhibition against Na+ , K+ -ATPase. Chemistry & biodiversity. 2020 Nov; 17(11):e2000529. doi: 10.1002/cbdv.202000529. [PMID: 32939944]
  • Zhe-Rui Zhang, Ya-Nan Zhang, Xiao-Dan Li, Hong-Qing Zhang, Shu-Qi Xiao, Fei Deng, Zhi-Ming Yuan, Han-Qing Ye, Bo Zhang. A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2. Signal transduction and targeted therapy. 2020 10; 5(1):218. doi: 10.1038/s41392-020-00343-z. [PMID: 33011739]
  • Haiyan Hu, Qi Qi, Ziyi Dong, Xianglong Yu, Yujia Mo, Juyuan Luo, Yan Wang, Shouying Du, Yang Lu. Albumin coated trimethyl chitosan-based targeting delivery platform for photothermal/chemo-synergistic cancer therapy. Carbohydrate polymers. 2020 Aug; 241(?):116335. doi: 10.1016/j.carbpol.2020.116335. [PMID: 32507205]
  • Min Li, Xi-Jie Wang, Qi Zhao, Jia-Xian Wang, Hong-Yan Xing, Yi-Zhe Zhang, Xue-Xia Zhang, Yang-Yang Zhi, Hua Li, Jing Ma. Bufalin-induced cardiotoxicity: new findings into mechanisms. Chinese journal of natural medicines. 2020 Jul; 18(7):550-560. doi: 10.1016/s1875-5364(20)30065-0. [PMID: 32616195]
  • Yueping Zhan, Yanyan Qiu, Haijing Wang, Ziyuan Wang, Jian Xu, Guohua Fan, Jianhua Xu, Wei Li, Yijun Cao, Van-Minh Le, Hai-Trieu Ly, Zeting Yuan, Ke Xu, Peihao Yin. Bufalin reverses multidrug resistance by regulating stemness through the CD133/nuclear factor-κB/MDR1 pathway in colorectal cancer. Cancer science. 2020 May; 111(5):1619-1630. doi: 10.1111/cas.14345. [PMID: 32058643]
  • Nam-Yi Kim, Young-Ah Suh, Soyoung Kim, ChuHee Lee. Bufalin down-regulates Axl expression to inhibit cell proliferation and induce apoptosis in non-small-cell lung cancer cells. Bioscience reports. 2020 04; 40(4):. doi: 10.1042/bsr20193959. [PMID: 32219334]
  • Katharina Schimmel, Mira Jung, Ariana Foinquinos, Gorka San José, Javier Beaumont, Katharina Bock, Lea Grote-Levi, Ke Xiao, Christian Bär, Angelika Pfanne, Annette Just, Karina Zimmer, Soeun Ngoy, Begoña López, Susana Ravassa, Sabine Samolovac, Heike Janssen-Peters, Janet Remke, Kristian Scherf, Seema Dangwal, Maria-Teresa Piccoli, Felix Kleemiss, Fabian Philipp Kreutzer, Franziska Kenneweg, Julia Leonardy, Lisa Hobuß, Laura Santer, Quoc-Tuan Do, Robert Geffers, Jan Hinrich Braesen, Jessica Schmitz, Christina Brandenberger, Dominik N Müller, Nicola Wilck, Volkhard Kaever, Heike Bähre, Sandor Batkai, Jan Fiedler, Kevin M Alexander, Bradley M Wertheim, Sudeshna Fisch, Ronglih Liao, Javier Diez, Arantxa González, Thomas Thum. Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation. 2020 03; 141(9):751-767. doi: 10.1161/circulationaha.119.042559. [PMID: 31948273]
  • Yue- Zhong, Chao- Zhao, Wen-Yu Wu, Tian-Yuan Fan, Nian-Guang Li, Min- Chen, Jin-Ao Duan, Zhi-Hao Shi. Total synthesis, chemical modification and structure-activity relationship of bufadienolides. European journal of medicinal chemistry. 2020 Mar; 189(?):112038. doi: 10.1016/j.ejmech.2020.112038. [PMID: 31945667]
  • Jinghui Zhang, Yanjun Hong, Lilong Jiang, Xiaojiao Yi, Yang Chen, Li Liu, Zhongjian Chen, Yongjiang Wu, Zongwei Cai. Global Metabolomic and Lipidomic Analysis Reveal the Synergistic Effect of Bufalin in Combination with Cinobufagin against HepG2 Cells. Journal of proteome research. 2020 02; 19(2):873-883. doi: 10.1021/acs.jproteome.9b00681. [PMID: 31942794]
  • Pedro Azalim, Fernando M do Monte, Mariana Manzano Rendeiro, Xiaofan Liu, George A O'Doherty, Carlos Frederico Fontes, Suzana Guimarães Leitão, Luis Eduardo M Quintas, François Noël. Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study. Biochemical pharmacology. 2020 01; 171(?):113679. doi: 10.1016/j.bcp.2019.113679. [PMID: 31669257]
  • Xian Zhang, Xiaoxuan Zhao, Kaili Liu, Yuxuan Che, Xun Qiu, Yanjun Qu, Xiuhua Sun, Jincheng Song. Bufalin: A Systematic Review of Research Hotspots and Antitumor Mechanisms by Text Mining and Bioinformatics. The American journal of Chinese medicine. 2020; 48(7):1633-1650. doi: 10.1142/s0192415x20500810. [PMID: 33148004]
  • Yu-Long Lan, Yu-Jie Zou, Jia-Cheng Lou, Jin-Shan Xing, Xun Wang, Shuang Zou, Bin-Bin Ma, Yan Ding, Bo Zhang. The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway. Cell biology and toxicology. 2019 12; 35(6):521-539. doi: 10.1007/s10565-019-09462-y. [PMID: 30739221]
  • Xiao Sun, Tony T H Ng, Kathy W Y Sham, Lin Zhang, Matthew T V Chan, William K K Wu, Christopher H K Cheng. Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer. Cancer prevention research (Philadelphia, Pa.). 2019 Oct; 12(10):653-666. doi: 10.1158/1940-6207.capr-19-0134. [PMID: 31431500]
  • Fei Cao, Ya-Bin Gong, Xiao-Hong Kang, Zhi-Hong Lu, Ying Wang, Ke-Lei Zhao, Zhan-Hui Miao, Ming-Juan Liao, Zhen-Ye Xu. Degradation of MCL-1 by bufalin reverses acquired resistance to osimertinib in EGFR-mutant lung cancer. Toxicology and applied pharmacology. 2019 09; 379(?):114662. doi: 10.1016/j.taap.2019.114662. [PMID: 31301315]
  • Jian-Jun Zhang, Xiao-Hui Zhou, Yan Zhou, Yong-Gang Wang, Bin-Zhi Qian, Ai-Na He, Zan Shen, Hai-Yan Hu, Yang Yao. Bufalin suppresses the migration and invasion of prostate cancer cells through HOTAIR, the sponge of miR-520b. Acta pharmacologica Sinica. 2019 Sep; 40(9):1228-1236. doi: 10.1038/s41401-019-0234-8. [PMID: 31028291]
  • Haijun Wang, Junzi Wu, Gareth R Williams, Qing Fan, Shiwei Niu, Jianrong Wu, Xiaotian Xie, Li-Min Zhu. Platelet-membrane-biomimetic nanoparticles for targeted antitumor drug delivery. Journal of nanobiotechnology. 2019 May; 17(1):60. doi: 10.1186/s12951-019-0494-y. [PMID: 31084622]
  • Wenlong Wei, Yang Yu, Xia Wang, Linhui Yang, Hang Zhang, Hongjian Ji, Zhenwei Li, Jinjun Hou, Wanying Wu, Dean Guo. Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC⁻MS/MS. Molecules (Basel, Switzerland). 2019 Apr; 24(9):. doi: 10.3390/molecules24091662. [PMID: 31035327]
  • Ying Xie, Xu Yan, Ling Sun. The Mechanism of Bufalin-Induced Apoptosis of K562/A02. Medical science monitor : international medical journal of experimental and clinical research. 2019 Apr; 25(?):2542-2552. doi: 10.12659/msm.915802. [PMID: 30955024]
  • Jia Liu, Ying Zhang, Shulan Sun, Guirong Zhang, Ke Jiang, Peixin Sun, Ye Zhang, Bing Yao, Rui Sui, Yi Chen, Xu Guo, Tao Tang, Ji Shi, Haiyang Liang, Haozhe Piao. Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide. Oncology research. 2019 Mar; 27(4):475-486. doi: 10.3727/096504018x15270916676926. [PMID: 29793559]
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