L-Valine (BioDeep_00000000071)

 

Secondary id: BioDeep_00000229648

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(2S)-2-amino-3-methylbutanoic acid

化学式: C5H11NO2 (117.079)
中文名称: L-缬氨酸, 缬氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 17.67%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

L-Valine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/l-valine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000071). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C)C(C(=O)O)N
InChI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)

描述信息

L-valine is the L-enantiomer of valine. It has a role as a nutraceutical, a micronutrient, a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a pyruvate family amino acid, a proteinogenic amino acid, a valine and a L-alpha-amino acid. It is a conjugate base of a L-valinium. It is a conjugate acid of a L-valinate. It is an enantiomer of a D-valine. It is a tautomer of a L-valine zwitterion.
Valine is a branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.
L-Valine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Valine is an aliphatic and extremely hydrophobic essential amino acid in humans related to leucine, Valine is found in many proteins, mostly in the interior of globular proteins helping to determine three-dimensional structure. A glycogenic amino acid, valine maintains mental vigor, muscle coordination, and emotional calm. Valine is obtained from soy, cheese, fish, meats and vegetables. Valine supplements are used for muscle growth, tissue repair, and energy. (NCI04)
Valine (abbreviated as Val or V) is an -amino acid with the chemical formula HO2CCH(NH2)CH(CH3)2. It is named after the plant valerian. L-Valine is one of 20 proteinogenic amino acids. Its codons are GUU, GUC, GUA, and GUG. This essential amino acid is classified as nonpolar. Along with leucine and isoleucine, valine is a branched-chain amino acid. Branched chain amino acids (BCAA) are essential amino acids whose carbon structure is marked by a branch point. These three amino acids are critical to human life and are particularly involved in stress, energy and muscle metabolism. BCAA supplementation as therapy, both oral and intravenous, in human health and disease holds great promise. BCAA denotes valine, isoleucine and leucine which are branched chain essential amino acids. Despite their structural similarities, the branched amino acids have different metabolic routes, with valine going solely to carbohydrates, leucine solely to fats and isoleucine to both. The different metabolism accounts for different requirements for these essential amino acids in humans: 12 mg/kg, 14 mg/kg and 16 mg/kg of valine, leucine and isoleucine respectively. Furthermore, these amino acids have different deficiency symptoms. Valine deficiency is marked by neurological defects in the brain, while isoleucine deficiency is marked by muscle tremors. Many types of inborn errors of BCAA metabolism exist, and are marked by various abnormalities. The most common form is the maple syrup urine disease, marked by a characteristic urinary odor. Other abnormalities are associated with a wide range of symptoms, such as mental retardation, ataxia, hypoglycemia, spinal muscle atrophy, rash, vomiting and excessive muscle movement. Most forms of BCAA metabolism errors are corrected by dietary restriction of BCAA and at least one form is correctable by supplementation with 10 mg of biotin daily. BCAA are decreased in patients with liver disease, such as hepatitis, hepatic coma, cirrhosis, extrahepatic biliary atresia or portacaval shunt; aromatic amino acids (AAA) tyrosine, tryptophan and phenylalanine, as well as methionine are increased in these conditions. Valine in particular, has been established as a useful supplemental therapy to the ailing liver. All the BCAA probably compete with AAA for absorption into the brain. Supplemental BCAA with vitamin B6 and zinc help normalize the BCAA:AAA ratio. In sickle-cell disease, valine substitutes for the hydrophilic amino acid glutamic acid in hemoglobin. Because valine is hydrophobic, the hemoglobin does not fold correctly. Valine is an essential amino acid, hence it must be ingested, usually as a component of proteins.
A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and ...
Valine (Val) or L-valine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-valine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Valine is found in all organisms ranging from bacteria to plants to animals. It is classified as a non-polar, uncharged (at physiological pH) aliphatic amino acid. Valine was first isolated from casein in 1901 by Hermann Emil Fischer. The name valine comes from valeric acid, which in turn is named after the plant valerian due to the presence of valine in the roots of the plant. Valine is essential in humans, meaning the body cannot synthesize it, and it must be obtained from the diet. Human dietary sources are foods that contain protein, such as meats, dairy products, soy products, beans and legumes. L-valine is a branched chain amino acid (BCAA). The BCAAs consist of leucine, valine and isoleucine (and occasionally threonine). BCAAs are essential amino acids whose carbon structure is marked by a branch point at the beta-carbon position. BCAAs are critical to human life and are particularly involved in stress, energy and muscle metabolism. BCAA supplementation as therapy, both oral and intravenous, in human health and disease holds great promise. BCAAs have different metabolic routes, with valine going solely to carbohydrates (glucogenic), leucine solely to fats (ketogenic) and isoleucine being both a glucogenic and a ketogenic amino acid. The different metabolism accounts for different requirements for these essential amino acids in humans: 12 mg/kg, 14 mg/kg and 16 mg/kg of valine, leucine and isoleucine respectively. Like other branched-chain amino acids, the catabolism of valine starts with the removal of the amino group by transamination, giving alpha-ketoisovalerate, an alpha-keto acid, which is converted to isobutyryl-CoA through oxidative decarboxylation by the branched-chain α-ketoacid dehydrogenase complex. This is further oxidised and rearranged to succinyl-CoA, which can enter the citric acid cycle. Furthermore, these amino acids have different deficiency symptoms. Valine deficiency is marked by neurological defects in the brain, while isoleucine deficiency is marked by muscle tremors. Many types of inborn errors of BCAA metabolism exist, and are marked by various abnormalities. The most common form is the maple syrup urine disease, marked by a characteristic urinary odor. Other abnormalities are associated with a wide range of symptoms, such as mental retardation, ataxia, hypoglycemia, spinal muscle atrophy, rash, vomiting and excessive muscle movement. Most forms of BCAA metabolism errors are corrected by dietary restriction of BCAA and at least one form is correctable by supplementation with 10 mg of biotin daily. BCAA are decreased in patients with liver disease, such as hepatitis, hepatic coma, cirrhosis, extrahepatic biliary atresia or portacaval shunt. Valine in particular, has been established as a useful supplemental therapy to the ailing liver. Valine, like other branched-chain amino acids, is associated with insulin resistance: higher levels of valine are observed in the blood of diabetic mice, rats, and humans (PMID: 25287287). Mice fed a valine deprivation diet for one day have improved insulin sensitivity and feeding of a valine deprivation diet for one week significantly decreases blood glucose levels (PMID: 24684822). In diet-induced obese and insulin resistant mice, a diet with decreased levels of valine and the other branched-chain amino acids results in reduced adiposity and improved insulin sensitivity (PMID: 29266268). In sickle-cell disease, valine substitutes for the hydrophilic amino acid glutamic acid in hemoglobin. Because valine ...
L-valine, also known as (2s)-2-amino-3-methylbutanoic acid or L-(+)-alpha-aminoisovaleric acid, belongs to valine and derivatives class of compounds. Those are compounds containing valine or a derivative thereof resulting from reaction of valine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. L-valine is soluble (in water) and a moderately acidic compound (based on its pKa). L-valine can be found in watermelon, which makes L-valine a potential biomarker for the consumption of this food product. L-valine can be found primarily in most biofluids, including cerebrospinal fluid (CSF), breast milk, urine, and blood, as well as in human epidermis and fibroblasts tissues. L-valine exists in all living species, ranging from bacteria to humans. In humans, L-valine is involved in several metabolic pathways, some of which include streptomycin action pathway, tetracycline action pathway, methacycline action pathway, and kanamycin action pathway. L-valine is also involved in several metabolic disorders, some of which include methylmalonic aciduria due to cobalamin-related disorders, 3-methylglutaconic aciduria type III, isovaleric aciduria, and methylmalonic aciduria. Moreover, L-valine is found to be associated with schizophrenia, alzheimers disease, paraquat poisoning, and hypervalinemia. L-valine is a non-carcinogenic (not listed by IARC) potentially toxic compound. Valine (abbreviated as Val or V) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH3+ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a side chain isopropyl group, making it a non-polar aliphatic amino acid. It is essential in humans, meaning the body cannot synthesize it: it must be obtained from the diet. Human dietary sources are foods that contain protein, such as meats, dairy products, soy products, beans and legumes. In the genetic code it is encoded by all codons starting with GU, namely GUU, GUC, GUA, and GUG (Applies to Valine, Leucine and Isoleucine)
This group of essential amino acids are identified as the branched-chain amino acids, BCAAs. Because this arrangement of carbon atoms cannot be made by humans, these amino acids are an essential element in the diet. The catabolism of all three compounds initiates in muscle and yields NADH and FADH2 which can be utilized for ATP generation. The catabolism of all three of these amino acids uses the same enzymes in the first two steps. The first step in each case is a transamination using a single BCAA aminotransferase, with a-ketoglutarate as amine acceptor. As a result, three different a-keto acids are produced and are oxidized using a common branched-chain a-keto acid dehydrogenase, yielding the three different CoA derivatives. Subsequently the metabolic pathways diverge, producing many intermediates.
The principal product from valine is propionylCoA, the glucogenic precursor of succinyl-CoA. Isoleucine catabolism terminates with production of acetylCoA and propionylCoA; thus isoleucine is both glucogenic and ketogenic. Leucine gives rise to acetylCoA and acetoacetylCoA, and is thus classified as strictly ketogenic.
There are a number of genetic diseases associated with faulty catabolism of the BCAAs. The most common defect is in the branched-chain a-keto acid dehydrogenase. Since there is only one dehydrogenase enzyme for all three amino acids, all three a-keto acids accumulate and are excreted in the urine. The disease is known as Maple syrup urine disease because of the characteristic odor of the urine in afflicted individuals. Mental retardation in these cases is extensive. Unfortunately, since these are essential amino acids, they cannot be heavily restricted in the diet; ultimately, the life of afflicted individuals is short and development is abnormal The main neurological pr...

L-Valine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=7004-03-7 (retrieved 2024-06-29) (CAS RN: 72-18-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
L-Valine (Valine) is a new nonlinear semiorganic material[1].
L-Valine (Valine) is a new nonlinear semiorganic material[1].

同义名列表

123 个代谢物同义名

L-Valine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0\\%; L-Valine, Pharmaceutical Secondary Standard; Certified Reference Material; InChI=1/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s; L-Valine, United States Pharmacopeia (USP) Reference Standard; L-Valine, dimer, meets the analytical specifications of USP; Valine, European Pharmacopoeia (EP) Reference Standard; L-Valine, certified reference material, TraceCERT(R); L-Valine, Cell Culture Reagent (H-L-Val-OH); L-Valine, Vetec(TM) reagent grade, >=98\\%; (S)-alpha-Amino-beta-methylbutyric acid; LYSINE ACETATE IMPURITY D [EP IMPURITY]; Butanoic acid, 2-amino-3-methyl-, (S)-; L-Valine, reagent grade, >=98\\% (HPLC); L-Valine, SAJ special grade, >=98.5\\%; L-alpha-Amino-beta-methylbutyric acid; 1B39571B-0AE8-4A9A-AE80-4B898D11A981; (S)-(+)-2-AMINO-3-METHYLBUTYRIC ACID; (S)-alpha-Amino-beta-methylbutyrate; 2-Amino-3-methylbutanoic acid, (S)-; 2-Amino-3-methylbutanoic acid (VAN); (S)-2-amino-3-methyl-Butanoic acid; 2-Amino-3-methylbutyric acid, (S)-; (2S)-2-amino-3-methylbutanoic acid; L-(+)-.alpha.-Aminoisovaleric acid; L-Valine, BioUltra, >=99.5\\% (NT); (S)-2-amino-3-methyl-butyric acid; L-alpha-Amino-beta-methylbutyrate; (S)-2-Amino-3-methylbutanoic acid; Butanoic acid, 2-amino-3-methyl-; (S)-2-Amino-3-methylbutyric acid; L-Valine, 99\\%, natural, FCC, FG; l-(+)-alpha-Aminoisovaleric acid; (S)-a-Amino-b-methylbutyric acid; L(+)-alpha-Aminoisovaleric acid; L-2-Amino-3-methylbutanoic acid; (2S)-2-amino-3-methylbutanoate; (S)-alpha-Aminoisovaleric acid; (S)-2-amino-3-methyl-Butanoate; L-Α-amino-β-methylbutyric acid; L-a-Amino-b-methylbutyric acid; (S)-2-Amino-3-methylbutanoate; 2-Amino-3-methylbutanoic acid; 2-Amino-3-methyl-butyric acid; L-(+)-alpha-Aminoisovalerate; L-(+)-Α-aminoisovaleric acid; L-(+)-a-Aminoisovaleric acid; (S)-a-Amino-b-methylbutyrate; (S)-2-Amino-3-methylbutyrate; 2-Amino-3-methylbutyric acid; (S)-?-Aminoisovaleric acid; (S)-A-Aminoisovaleric acid; 2-Aminoisovaleric acid,(S); L-a-Amino-b-methylbutyrate; L-Α-amino-β-methylbutyrate; alpha-aminoisovaleric acid; 2-amino-3-methylbutanoate; L-(+)-Α-aminoisovalerate; 2-Amino-3-methylbutyrate; L-(+)-a-Aminoisovalerate; L-2-Aminoisovaleric Acid; L-Valine, 98.5-101.5\\%; 2-aminoisovaleric acid; VALINE [USP MONOGRAPH]; VALINE (USP MONOGRAPH); VALINE [EP MONOGRAPH]; L-iso-C3H7CH(NH2)COOH; VALINE (EP MONOGRAPH); L-VALINE [USP-RS]; Valine [USAN:INN]; Valine (L-Valine); Valina [Spanish]; Valinum [Latin]; UNII-HG18B9YRS7; Valinum (Latin); VALINE [WHO-DD]; L-Valine (JP17); L-VALINE [FCC]; Racemic valine; L-Valine, 99\\%; L-VALINE [JAN]; VALINE [VANDF]; VALINE [MART.]; VALINE (MART.); VALINE [HSDB]; VALINE [INCI]; L-Valine, FCC; VALINE [USAN]; L-Valine,(S); Valine (VAN); VALINE [INN]; Valine (USP); VALINE (II); 3h-l-valine; VALINE [MI]; VALINE [II]; HG18B9YRS7; VALINE, L-; (S)-Valine; (+)-valine; (L)-valine; L-Valine;; DL-Valine; L-Valine; L-VAL-OH; L Valine; H-Val-OH; L-valin; (S)-Val; Valinum; L-Val-4; s-valin; valina; Valine; valin; L-Val; Hval; 1t4s; val; V; poly-l-valine; Valine; L-Valine; Valine



数据库引用编号

62 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

92 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(5)

WikiPathways(1)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(84)

PharmGKB(0)

486 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ACE, CAT, CDKN1A, CYP1A1, ERBB2, GSTM1, GSTP1, HPGDS, IARS1, PRNP, SLC6A3
Peripheral membrane protein 2 CYP1A1, CYP1B1
Endosome membrane 2 ERBB2, INSR
Endoplasmic reticulum membrane 2 CYP1A1, CYP1B1
Nucleus 3 CDKN1A, ERBB2, GSTP1
cytosol 9 CAT, CDKN1A, ERBB2, GSTM1, GSTP1, HPGDS, IARS1, MTHFR, PRNP
dendrite 1 PRNP
nuclear body 1 CDKN1A
nucleoplasm 4 CDKN1A, ERBB2, HPGDS, IARS1
Cell membrane 5 ACE, ERBB2, INSR, PRNP, SLC6A3
ruffle membrane 1 ERBB2
Cell projection, axon 1 SLC6A3
Multi-pass membrane protein 1 SLC6A3
cell surface 2 PRNP, SLC6A3
Golgi apparatus 1 PRNP
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ERBB2
neuronal cell body 1 SLC6A3
postsynapse 1 PRNP
presynaptic membrane 2 ERBB2, SLC6A3
Cytoplasm, cytosol 1 IARS1
Lysosome 2 ACE, INSR
endosome 1 ACE
plasma membrane 7 ACE, ERBB2, F2, INSR, PRNP, REN, SLC6A3
terminal bouton 1 PRNP
Membrane 9 ACE, CAT, CYP1B1, ERBB2, IARS1, INSR, PRNP, REN, SLC6A3
apical plasma membrane 1 ERBB2
axon 2 INSR, SLC6A3
basolateral plasma membrane 1 ERBB2
caveola 1 INSR
extracellular exosome 10 ACE, CAT, F2, GSTP1, IARS1, INSR, LYZ, PRNP, SOD2, TTR
endoplasmic reticulum 1 PRNP
extracellular space 6 ACE, F2, GSTP1, LYZ, REN, TTR
perinuclear region of cytoplasm 2 CDKN1A, ERBB2
mitochondrion 6 CAT, CYP1A1, CYP1B1, GSTP1, PRNP, SOD2
protein-containing complex 2 CAT, CDKN1A
intracellular membrane-bounded organelle 5 CAT, CYP1A1, CYP1B1, HPGDS, PRNP
Microsome membrane 2 CYP1A1, CYP1B1
postsynaptic density 1 PRNP
Single-pass type I membrane protein 3 ACE, ERBB2, INSR
Secreted 4 ACE, F2, REN, TTR
extracellular region 9 ACE, CAT, ELN, ERBB2, F2, GSTP1, LYZ, REN, TTR
Mitochondrion outer membrane 1 PRNP
Single-pass membrane protein 1 PRNP
mitochondrial outer membrane 1 PRNP
neuronal cell body membrane 2 INSR, SLC6A3
Mitochondrion matrix 1 SOD2
mitochondrial matrix 2 CAT, SOD2
nuclear membrane 1 PRNP
external side of plasma membrane 3 ACE, INSR, PRNP
Secreted, extracellular space, extracellular matrix 1 ELN
cytoplasmic vesicle 1 ERBB2
nucleolus 1 CDKN1A
Early endosome 1 ERBB2
apical part of cell 1 REN
vesicle 1 GSTP1
postsynaptic membrane 1 SLC6A3
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 2 PRNP, SLC6A3
focal adhesion 1 CAT
flotillin complex 1 SLC6A3
extracellular matrix 1 ELN
mitochondrial nucleoid 1 SOD2
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 ELN, F2
Late endosome 1 INSR
receptor complex 2 ERBB2, INSR
Cell projection, neuron projection 1 SLC6A3
neuron projection 1 SLC6A3
brush border membrane 1 ACE
blood microparticle 1 F2
sperm midpiece 1 ACE
Lipid-anchor, GPI-anchor 1 PRNP
intercellular bridge 1 GSTM1
side of membrane 1 PRNP
myelin sheath 1 ERBB2
basal plasma membrane 2 ACE, ERBB2
ficolin-1-rich granule lumen 2 CAT, GSTP1
secretory granule lumen 2 CAT, GSTP1
Golgi lumen 1 F2
endoplasmic reticulum lumen 1 F2
axon terminus 1 SLC6A3
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
extrinsic component of membrane 1 PRNP
azurophil granule lumen 2 LYZ, TTR
semaphorin receptor complex 1 ERBB2
[Isoform 1]: Cell membrane 1 ERBB2
dopaminergic synapse 1 SLC6A3
aminoacyl-tRNA synthetase multienzyme complex 1 IARS1
dendrite membrane 1 INSR
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
elastic fiber 1 ELN
catalase complex 1 CAT
inclusion body 1 PRNP
ERBB3:ERBB2 complex 1 ERBB2
insulin receptor complex 1 INSR
TRAF2-GSTP1 complex 1 GSTP1
PCNA-p21 complex 1 CDKN1A
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE


文献列表

  • Jing Ni, Yue Zhang, Shaowei Zhai, Hejian Xiong, Yanlin Ming, Ying Ma. Preparation of valine-curcumin conjugate and its in vitro antibacterial and antitumor activity and in vivo biological effects on American eels (Anguilla rostrata). Fish & shellfish immunology. 2024 Jun; 149(?):109615. doi: 10.1016/j.fsi.2024.109615. [PMID: 38719095]
  • Ahmed Adel Ali Youssef, Muna Hayder Abdelrahman, Mona M Geweda, Corinne Varner, Poorva H Joshi, Mihir Ghonge, Narendar Dudhipala, Suresh P Sulochana, Rama S Gadepalli, Soumyajit Majumdar. Formulation and In Vitro-Ex vivo Evaluation of Cannabidiol and Cannabidiol-Valine-Hemisuccinate Loaded Lipid-Based Nanoformulations for Ocular Applications. International journal of pharmaceutics. 2024 May; 657(?):124110. doi: 10.1016/j.ijpharm.2024.124110. [PMID: 38604539]
  • Pengliang Han, Chengli Wang, Fudong Li, Meilian Li, Jiajun Nie, Ming Xu, Hao Feng, Liangsheng Xu, Cong Jiang, Qingmei Guan, Lili Huang. Valsa mali PR1-like protein modulates an apple valine-glutamine protein to suppress JA signaling-mediated immunity. Plant physiology. 2024 Jan; ?(?):. doi: 10.1093/plphys/kiae020. [PMID: 38235781]
  • Anna Szuba-Trznadel, Anna Jama-Rodzeńska, Bernard Gałka, Rafał Ramut, Zygmunt Król, Daniel Jarki, Dragana Latković. The impact of the distribution method for struvite (Crystal Green) on the chemical composition of soybean and their utility in animal nutrition. Scientific reports. 2024 01; 14(1):1093. doi: 10.1038/s41598-024-51625-3. [PMID: 38212440]
  • Sergej Nadalin, Lena Zatković, Vjekoslav Peitl, Dalibor Karlović, Maja Vilibić, Ante Silić, Sanja Dević Pavlić, Alena Buretić-Tomljanović. An association between PPARα-L162V polymorphism and increased plasma LDL cholesterol levels after risperidone treatment. Prostaglandins, leukotrienes, and essential fatty acids. 2024 Jan; 200(?):102604. doi: 10.1016/j.plefa.2023.102604. [PMID: 38113727]
  • Hui Yang, Yan-Ru Liu, Zhong-Xing Song, Zhi-Shu Tang, Ai-Ling Jia, Ming-Geng Wang, Jin-Ao Duan. Study on the underlying mechanism of Poria in intervention of arrhythmia zebrafish by integrating metabolomics and network pharmacology. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155143. doi: 10.1016/j.phymed.2023.155143. [PMID: 37890443]
  • Xinbo Zhou, Junjie Zhang, Jian Shen, Baojing Cheng, Chongpeng Bi, Qingquan Ma. Branched-chain amino acid modulation of lipid metabolism, gluconeogenesis, and inflammation in a finishing pig model: targeting leucine and valine. Food & function. 2023 Nov; 14(22):10119-10134. doi: 10.1039/d3fo03899h. [PMID: 37882496]
  • Xuan Liao, Bingyan Wu, Haixia Li, Mengtao Zhang, Muzi Cai, Bozhi Lang, Zhizhen Wu, Fangling Wang, Jianong Sun, Panpan Zhou, Hongli Chen, Duolong Di, Cuiling Ren, Haixia Zhang. Fluorescent/Colorimetric Dual-Mode Discriminating Gln and Val Enantiomers Based on Carbon Dots. Analytical chemistry. 2023 10; 95(39):14573-14581. doi: 10.1021/acs.analchem.3c01854. [PMID: 37729469]
  • Jiao Wang, Chunyu Zhou, Qing Zhang, Zhangsuo Liu. Metabolomic profiling of amino acids study reveals a distinct diagnostic model for diabetic kidney disease. Amino acids. 2023 Sep; ?(?):. doi: 10.1007/s00726-023-03330-0. [PMID: 37736814]
  • Seungyoun Jung, Sarah Silva, Cher M Dallal, Erin LeBlanc, Kenneth Paris, John Shepherd, Linda G Snetselaar, Linda Van Horn, Yuji Zhang, Joanne F Dorgan. Untargeted serum metabolomic profiles and breast density in young women. Cancer causes & control : CCC. 2023 Sep; ?(?):. doi: 10.1007/s10552-023-01793-w. [PMID: 37737303]
  • Jiashen Cai, Crystal Chun Yuen Chong, Ching Yu Cheng, Cynthia Ciwei Lim, Charumathi Sabanayagam. Circulating metabolites and cardiovascular disease in Asians with chronic kidney disease. Cardiorenal medicine. 2023 Sep; ?(?):. doi: 10.1159/000533741. [PMID: 37669626]
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