Scopoletol (BioDeep_00000859325)

Main id: BioDeep_00000397986

 

PANOMIX_OTCML-2023


代谢物信息卡片


2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy- (9CI)

化学式: C10H8O4 (192.0423)
中文名称: 东莨菪素, 莨菪亭
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)C=CC(=O)O2)O
InChI: InChI=1S/C10H8O4/c1-13-9-4-6-2-3-10(12)14-8(6)5-7(9)11/h2-5,11H,1H3

描述信息

Scopoletin is an inhibitor of acetylcholinesterase (AChE).
Scopoletin is an inhibitor of acetylcholinesterase (AChE).

同义名列表

73 个代谢物同义名

2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy- (9CI); 5-18-03-00203 (Beilstein Handbook Reference); 2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy-; 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one; 7-Hydroxy-6-methoxy-2H-chromen-2-one; 7-hydroxy-6-methoxy-chromen-2-one; 7-hydroxy-6-methoxychromen-2-one; 7-hydroxy-6-methoxy-2-chromenone; COUMARIN, 7-HYDROXY-6-METHOXY-; 7-hydroxy-6-methoxy-coumarin; 7-Hydroxy-5-methoxycoumarin; 7-Hydroxy-6-methoxycoumarin; 6-Methoxy-7-hydroxycoumarin; Esculetin 6-methyl ether; Esculetin-6-methyl ether; 6-Methoxyumbelliferone; .beta.-Methylesculetin; beta-Methylesculetin; 6-O-Methylesculetin; Prestwick2_000962; 6-Methylesculetin; Prestwick3_000962; Prestwick0_000962; Chrysatropic acid; Prestwick1_000962; Spectrum4_001054; Spectrum2_001207; Spectrum5_000654; EINECS 202-171-9; Spectrum3_001532; NCGC00016349-01; NCGC00094973-02; NCGC00016349-02; NCGC00094973-03; SPECTRUM1502242; NCGC00094973-01; Gelseminic acid; BSPBio_000963; BSPBio_002944; BPBio1_001061; DivK1c_000720; KBioGR_001348; MEGxp0_001192; SPBio_002884; KBio3_002444; ACon1_000143; NINDS_000720; KBio1_000720; SPBio_000994; NCI60_003834; ZINC00057733; CHEBI:17488; BRN 0156296; S2500_SIGMA; AIDS-014975; IDI1_000720; 84792_FLUKA; Escopoletin; Scopoletine; CAS-92-61-5; CCRIS 3592; Scopoletol; AIDS014975; Scopoletin; Murrayetin; NSC 405647; NSC405647; ST056287; TNP00096; 92-61-5; C01752; Scopoletin; Scopoletin



数据库引用编号

13 个数据库交叉引用编号

分类词条

684 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 AKR1B1, AKT1, ANG, BCL2, CASP3, CAT, EGFR, MAPK14, NFE2L2, PIK3CA, PRKAA2, PTGS2, TP53, TYR, VEGFA
Peripheral membrane protein 3 ACHE, CYP1B1, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 4 BCL2, CYP1B1, EGFR, PTGS2
Nucleus 11 ACHE, AKT1, ANG, BCL2, CASP3, EGFR, MAPK14, NFE2L2, PRKAA2, TP53, VEGFA
cytosol 11 AKR1B1, AKT1, ANG, BCL2, CASP3, CAT, MAPK14, NFE2L2, PIK3CA, PRKAA2, TP53
dendrite 1 PRKAA2
centrosome 2 NFE2L2, TP53
nucleoplasm 7 AKR1B1, AKT1, CASP3, MAPK14, NFE2L2, PRKAA2, TP53
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 4 ACHE, AKT1, EGFR, TNF
lamellipodium 2 AKT1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Synapse 1 ACHE
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 4 ACHE, EGFR, TNF, VEGFA
glutamatergic synapse 4 AKT1, CASP3, EGFR, MAPK14
Golgi apparatus 4 ACHE, NFE2L2, PRKAA2, VEGFA
Golgi membrane 2 EGFR, INS
growth cone 1 ANG
neuromuscular junction 1 ACHE
neuronal cell body 4 ANG, CASP3, PRKAA2, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 TYR
endosome 1 EGFR
plasma membrane 6 ACHE, AKT1, EGFR, NFE2L2, PIK3CA, TNF
Membrane 9 ACHE, AKT1, BCL2, CAT, CYP1B1, EGFR, PRKAA2, TP53, VEGFA
apical plasma membrane 1 EGFR
axon 1 PRKAA2
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 2 AKR1B1, CAT
endoplasmic reticulum 4 BCL2, PTGS2, TP53, VEGFA
extracellular space 8 ACHE, AKR1B1, ANG, EGFR, IL6, INS, TNF, VEGFA
perinuclear region of cytoplasm 4 ACHE, EGFR, PIK3CA, TYR
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 6 AKR1B1, BCL2, CAT, CYP1B1, MAPK14, TP53
protein-containing complex 6 AKT1, BCL2, CAT, EGFR, PTGS2, TP53
intracellular membrane-bounded organelle 3 CAT, CYP1B1, TYR
Microsome membrane 2 CYP1B1, PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 EGFR, TYR
Secreted 5 ACHE, ANG, IL6, INS, VEGFA
extracellular region 8 ACHE, ANG, CAT, IL6, INS, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
Extracellular side 1 ACHE
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
microtubule cytoskeleton 1 AKT1
nucleolus 2 ANG, TP53
Melanosome membrane 1 TYR
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 CAT, EGFR
spindle 1 AKT1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 2 ACHE, ANG
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 EGFR
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, TP53
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
Chromosome 1 ANG
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
endosome lumen 1 INS
Melanosome 1 TYR
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 ACHE
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • M Salihu, L G Hassan, U Z Faruq, A J Yusuf. Deciphering the interactions of scopoletin and scopolin from Catunaregam nilotica roots against Naja nigricollis phospholipase A2 enzyme. Toxicon : official journal of the International Society on Toxinology. 2024 May; 243(?):107732. doi: 10.1016/j.toxicon.2024.107732. [PMID: 38642905]
  • Sourav Kundu, Sitara Ghosh, Bidya Dhar Sahu. Scopoletin alleviates high glucose-induced toxicity in human renal proximal tubular cells via inhibition of oxidative damage, epithelial-mesenchymal transition, and fibrogenesis. Molecular biology reports. 2024 May; 51(1):620. doi: 10.1007/s11033-024-09579-2. [PMID: 38709349]
  • Jing Wang, Peitao Chen, Tengfei Zhao, Xianhui Huang, Jikai Zong, Qingqing Luo, Chao Peng, Xiaoyan Wu, Fei Qiu, Dongchao Zhao, Lien Xiang, Yan Zhang, Chunxian Yang, Fangyuan Zhang, Zhihua Liao, Yufan Fu, Junlan Zeng. Biosynthesis of Scopoletin in Sweet Potato Confers Resistance against Fusarium oxysporum. Journal of agricultural and food chemistry. 2024 Apr; 72(14):7749-7764. doi: 10.1021/acs.jafc.3c09389. [PMID: 38537104]
  • Hong Zhou, Yeshuang Ning, Yufan Jian, Miao Zhang, Matthana Klakong, Fuyou Guo, Qingyi Shao, Yanhong Li, Pinglong Yang, Zongquan Li, Liang Yang, Shili Li, Wei Ding. Functional analysis of a down-regulated transcription factor-SoxNeuroA gene involved in the acaricidal mechanism of scopoletin against spider mites. Pest management science. 2023 Nov; ?(?):. doi: 10.1002/ps.7892. [PMID: 37986233]
  • Na Song, Jinsong Wu. Synergistic induction of phytoalexins in Nicotiana attenuata by JA and ethylene signaling mediated by NaWRKY70. Journal of experimental botany. 2023 Oct; ?(?):. doi: 10.1093/jxb/erad415. [PMID: 37870145]
  • Vincent Lebot, Floriane Lawac, Ismaël Muñoz-Cuervo, Pierre-Edouard Mercier, Laurent Legendre. Metabolite fingerprinting of cassava (Manihot esculenta Crantz) landraces assessed for post-harvest physiological deterioration (PPD). Food chemistry. 2023 Sep; 421(?):136217. doi: 10.1016/j.foodchem.2023.136217. [PMID: 37121018]
  • Swati Sharma, Vishal Sharma, Sunil Taneja, Alka Bhatia, Aishwarya Anand, Amol N Patil, Dibyajyoti Banerjee. Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats. Journal of complementary & integrative medicine. 2023 Sep; ?(?):. doi: 10.1515/jcim-2023-0168. [PMID: 37732506]
  • Alexander Beesley, Sebastian F Beyer, Verena Wanders, Sophie Levecque, Sandra Bredenbruch, Samer S Habash, A Sylvia S Schleker, Jochem Gätgens, Marco Oldiges, Holger Schultheiss, Uwe Conrath, Caspar J G Langenbach. Engineered coumarin accumulation reduces mycotoxin-induced oxidative stress and disease susceptibility. Plant biotechnology journal. 2023 Aug; ?(?):. doi: 10.1111/pbi.14144. [PMID: 37578146]
  • Nishit D Patel, Samir G Patel, Amit A Patel, Manan A Raval. Estimation of Scopoletin from Roots of Argyreia nervosa (Burm. fill.) Bojer Using a Validated HPLC-Fluorescence Method Optimized Using the Design of Experiment Approach. Journal of AOAC International. 2023 Jul; 106(4):992-1002. doi: 10.1093/jaoacint/qsad018. [PMID: 36707989]
  • Qinggang Yin, Tianze Wu, Ranran Gao, Lan Wu, Yuhua Shi, Xingwen Wang, Mengyue Wang, Zhichao Xu, Yueliang Zhao, Xiaojia Su, Yanyan Su, Xiaoyan Han, Ling Yuan, Li Xiang, Shilin Chen. Multi-omics reveal key enzymes involved in the formation of phenylpropanoid glucosides in Artemisia annua. Plant physiology and biochemistry : PPB. 2023 Jun; 201(?):107795. doi: 10.1016/j.plaphy.2023.107795. [PMID: 37301186]
  • Kripa Shankar Nainawat, Sarita Singh, Karishma Agarwal, Hina Iqbal, Poonam Rani, Divya Bhatt, Sana Khan, Debabrata Chanda, Dnyaneshwar Umrao Bawankule, Sudeep Tandon, Feroz Khan, Anil Kumar Gupta, Atul Gupta. Synthesis of 6-alkoxy and 6-hydroxy-alkyl amine derivatives of braylin as vasorelaxing agents. Bioorganic & medicinal chemistry letters. 2023 06; 89(?):129311. doi: 10.1016/j.bmcl.2023.129311. [PMID: 37149230]
  • Jieren Liao, Guangxin Sun, Elisabeth Kurze, Wieland Steinchen, Timothy D Hoffmann, Chuankui Song, Zhiwei Zou, Thomas Hoffmann, Wilfried G Schwab. Subfunctionalization of a monolignol to a phytoalexin glucosyltransferase is accompanied by substrate inhibition. Plant communications. 2023 05; 4(3):100506. doi: 10.1016/j.xplc.2022.100506. [PMID: 36566353]
  • Siqi Liu, Pengmin Ding, Mengjiao Wu, Zhihao Zhu, Jiayue Tao, Jing Wang, Zhe Xue, Rufeng Wang. Screening quality markers (Q-markers) of Xiaoer Chaige Tuire Oral Liquid by in vitro sequential metabolism and in vivo biopharmaceutical analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Apr; 116(?):154844. doi: 10.1016/j.phymed.2023.154844. [PMID: 37163902]
  • Kunpeng Yu, Cheng Peng, Yanling Lin, Lijun Li, Hui Ni, Qingbiao Li. [Expression of β-glucosidase An-bgl3 from Aspergillus niger for conversion of scopolin]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2023 Mar; 39(3):1232-1246. doi: 10.13345/j.cjb.220709. [PMID: 36994584]
  • Yifan Sun, Guangxi Ren, Qijin Shi, Hongyu Zhu, Na Zhou, Xianghe Kong, Dan Jiang, Chunsheng Liu. Identification of a Novel Coumarins Biosynthetic Pathway in the Endophytic Fungus Fusarium oxysporum GU-7 with Antioxidant Activity. Applied and environmental microbiology. 2023 01; 89(1):e0160122. doi: 10.1128/aem.01601-22. [PMID: 36598487]
  • Zhong Wang, Lanxin Ma, Pingping Liu, Zhaopeng Luo, Zefeng Li, Mingzhu Wu, Xin Xu, Wenxuan Pu, Pingjun Huang, Jun Yang. Transcription factor NtWRKY33a modulates the biosynthesis of polyphenols by targeting NtMYB4 and NtHCT genes in tobacco. Plant science : an international journal of experimental plant biology. 2023 Jan; 326(?):111522. doi: 10.1016/j.plantsci.2022.111522. [PMID: 36332766]
  • Israt Jahan, Shahenur Alam Sakib, Najmul Alam, Mohuya Majumder, Sanjida Sharmin, A S M Ali Reza. Pharmacological insights into Chukrasia velutina bark: Experimental and computer-aided approaches. Animal models and experimental medicine. 2022 12; 5(4):377-388. doi: 10.1002/ame2.12268. [PMID: 36047481]
  • Jia Sun, Jian Gou, Li-Qin Liu, Chun-Hua Liu, Jie Pan, Yue-Ting Li, Zi-Peng Gong. [Excretion of Cynanchum auriculatum extract in urine and feces of normal and functional dyspepsia rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Dec; 47(23):6355-6364. doi: 10.19540/j.cnki.cjcmm.20220621.202. [PMID: 36604880]
  • Jia Sun, Li-Qin Liu, Jian Gou, Si-Ying Chen, Zi-Peng Gong, Ting Liu, Yong-Jun Li, Yuan Lu. [Differences in intestinal absorption characteristics of Cynanchum auriculatum extract based on in situ intestinal circulation perfusion model in two states]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Dec; 47(23):6340-6347. doi: 10.19540/j.cnki.cjcmm.20220621.203. [PMID: 36604878]
  • Farah Naz, Mukesh Kumar, Tirthankar Koley, Priyanka Sharma, Muhammad Anzarul Haque, Arti Kapil, Manoj Kumar, Punit Kaur, Abdul Samath Ethayathulla. Screening of plant-based natural compounds as an inhibitor of FtsZ from Salmonella Typhi using the computational, biochemical and in vitro cell-based studies. International journal of biological macromolecules. 2022 Oct; 219(?):428-437. doi: 10.1016/j.ijbiomac.2022.07.241. [PMID: 35932806]
  • Joana L Rodrigues, Daniela Gomes, Lígia R Rodrigues. Challenges in the Heterologous Production of Furanocoumarins in Escherichia coli. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217230. [PMID: 36364054]
  • Meiwei Zhao, Lan Ma, Na Song, Junbin Cheng, Zhengxiong Zhao, Jinsong Wu. The regulation of Alternaria alternata resistance by LRR-RK4 through ERF109, defensin19 and phytoalexin scopoletin in Nicotiana attenuata. Plant science : an international journal of experimental plant biology. 2022 Oct; 323(?):111414. doi: 10.1016/j.plantsci.2022.111414. [PMID: 35963495]
  • Théodora K Kowa, Olivia Jansen, Allison Ledoux, Lucia Mamede, Hippolyte K Wabo, Alembert T Tchinda, Gregory Genta-Jouve, Michel Frédérich. Bioassay-guided isolation of vilasinin-type limonoids and phenyl alkene from the leaves of Trichilia gilgiana and their antiplasmodial activities. Natural product research. 2022 Oct; 36(19):5039-5047. doi: 10.1080/14786419.2021.1920017. [PMID: 33951995]
  • Muqeet Wahid, Fatima Saqib, Muhammad Qamar, Zyta M Ziora. Antispasmodic activity of the ethanol extract of Citrullus lanatus seeds: Justifying ethnomedicinal use in Pakistan to treat asthma and diarrhea. Journal of ethnopharmacology. 2022 Sep; 295(?):115314. doi: 10.1016/j.jep.2022.115314. [PMID: 35490899]
  • Qiuxiang Ma, Jia Xu, Yancai Feng, Xiaoyun Wu, Xinlu Lu, Peng Zhang. Knockdown of p-Coumaroyl Shikimate/Quinate 3'-Hydroxylase Delays the Occurrence of Post-Harvest Physiological Deterioration in Cassava Storage Roots. International journal of molecular sciences. 2022 Aug; 23(16):. doi: 10.3390/ijms23169231. [PMID: 36012496]
  • Lucia Dwi Antika, Aprilia Nur Tasfiyati, Hikmat Hikmat, Abdi Wira Septama. Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2022 Jul; 77(7-8):303-316. doi: 10.1515/znc-2021-0193. [PMID: 35218175]
  • Li-Qin Liu, Jing-Ya Zhang, Yuan Lu, Chun-Hua Liu, Jian Gou, Zhu-Jun Li, Ai-Min Wang, Jia Sun. [Intestinal absorption characteristics of root tuber of Cynanchum auriculatum extract in normal and functional dyspepsia model rats via everted intestine sac model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Jul; 47(14):3915-3922. doi: 10.19540/j.cnki.cjcmm.20220215.201. [PMID: 35850850]
  • Meng Xu, Zhang-Xin Yu, Bin Zhang, Xiao-Bao Li, Mu-Yuan Li, Wei Xu, Guang-Ying Chen. [Chemical constituents with α-glucosidase inhibitory activities from seeds of Morinda citrifolia (Noni)]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Jul; 47(13):3519-3525. doi: 10.19540/j.cnki.cjcmm.20211228.201. [PMID: 35850804]
  • Dey Parama, Sosmitha Girisa, Elina Khatoon, Aviral Kumar, Mohammed S Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar B Kunnumakkara. An overview of the pharmacological activities of scopoletin against different chronic diseases. Pharmacological research. 2022 05; 179(?):106202. doi: 10.1016/j.phrs.2022.106202. [PMID: 35378275]
  • Xiaoyun Wu, Jia Xu, Qiuxiang Ma, Sulaiman Ahmed, Xinlu Lu, Erjun Ling, Peng Zhang. Lysozyme inhibits postharvest physiological deterioration of cassava. Journal of integrative plant biology. 2022 Mar; 64(3):621-624. doi: 10.1111/jipb.13219. [PMID: 35195347]
  • Aprilia Nur Tasfiyati, Lucia Dwi Antika, Rizna Triana Dewi, Abdi Wira Septama, Akhmad Sabarudin, Teni Ernawati. An experimental design approach for the optimization of scopoletin extraction from Morinda citrifolia L. using accelerated solvent extraction. Talanta. 2022 Feb; 238(Pt 1):123010. doi: 10.1016/j.talanta.2021.123010. [PMID: 34857344]
  • Zongmei Wu, Yana Geng, Manon Buist-Homan, Han Moshage. Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress. Toxicology and applied pharmacology. 2022 02; 436(?):115858. doi: 10.1016/j.taap.2021.115858. [PMID: 34979142]
  • Zhongxiang Fan, Dan Tang, Qiang Wu, Qun Huang, Jie Song, Qiping Long. Scopoletin inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells by regulating NF-κB signaling pathway. Allergologia et immunopathologia. 2022; 50(1):92-98. doi: 10.15586/aei.v50i1.517. [PMID: 34965643]
  • Seon Gyeong Bak, Hyung-Jin Lim, Yeong-Seon Won, Soyoung Lee, Sun Hee Cheong, Seong Jin Lee, Eun Young Bae, Seung Woong Lee, Seung Jae Lee, Mun-Chual Rho. Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation. BioMed research international. 2022; 2022(?):2475699. doi: 10.1155/2022/2475699. [PMID: 36158872]
  • Darille Claudia Ngnokam Jouogo, Jean-De-Dieu Tamokou, Rémy Bertrand Teponno, Germaine Matsuete-Takongmo, Laurence Voutquenne-Nazabadioko, Léon Azefack Tapondjou, David Ngnokam. Chemotaxonomy and Antibacterial Activity of the Extracts and Chemical Constituents of Psychotria succulenta Hiern. (Rubiaceae). BioMed research international. 2022; 2022(?):7856305. doi: 10.1155/2022/7856305. [PMID: 35757466]
  • Marwa M Khalaf, Samar M Hassan, Ahmed M Sayed, Amira M Abo-Youssef. Ameliorate impacts of scopoletin against vancomycin-induced intoxication in rat model through modulation of Keap1-Nrf2/HO-1 and IκBα-P65 NF-κB/P38 MAPK signaling pathways: Molecular study, molecular docking evidence and network pharmacology analysis. International immunopharmacology. 2022 Jan; 102(?):108382. doi: 10.1016/j.intimp.2021.108382. [PMID: 34848155]
  • Preksha Patel, Manan Raval, Nidhi Patel, Samir Patel, Niraj Vyas, Amit Patel. Quantification of Scopoletin from the Roots of Argyreia Speciosa (Linn. F) Sweet Using HPLC Through the Concept of Design of Experiment. Journal of AOAC International. 2021 Aug; 104(4):1167-1180. doi: 10.1093/jaoacint/qsab013. [PMID: 33515243]
  • Marco Cosme, Iván Fernández, Stéphane Declerck, Marcel G A van der Heijden, Corné M J Pieterse. A coumarin exudation pathway mitigates arbuscular mycorrhizal incompatibility in Arabidopsis thaliana. Plant molecular biology. 2021 Jul; 106(4-5):319-334. doi: 10.1007/s11103-021-01143-x. [PMID: 33825084]
  • Ankita R Rane, Harshad Paithankar, Ramakrishna V Hosur, Sinjan Choudhary. Modulation of α-synuclein fibrillation by plant metabolites, daidzein, fisetin and scopoletin under physiological conditions. International journal of biological macromolecules. 2021 Jul; 182(?):1278-1291. doi: 10.1016/j.ijbiomac.2021.05.071. [PMID: 33991558]
  • Jiranan Chaingam, Thaweesak Juengwatanatrakul, Gorawit Yusakul, Tripetch Kanchanapoom, Waraporn Putalun. HPLC-UV-Based Simultaneous Determination of Canthin-6-One Alkaloids, Quassinoids, and Scopoletin: The Active Ingredients in Eurycoma Longifolia Jack and Eurycoma Harmandiana Pierre, and Their Anti-Inflammatory Activities. Journal of AOAC International. 2021 Jun; 104(3):802-810. doi: 10.1093/jaoacint/qsaa141. [PMID: 33064798]
  • Qilei Chen, Lin Zhu, Ka Man Yip, Yancheng Tang, Yi Liu, Tao Jiang, Jianye Zhang, Zhongzhen Zhao, Tao Yi, Hubiao Chen. A hybrid platform featuring nanomagnetic ligand fishing for discovering COX-2 selective inhibitors from aerial part of Saussurea laniceps Hand.-Mazz. Journal of ethnopharmacology. 2021 May; 271(?):113849. doi: 10.1016/j.jep.2021.113849. [PMID: 33485983]
  • Yijun Liang, Xuxin Zeng, Jialiang Guo, Hui Liu, Bao He, Renyu Lai, Quan Zhu, Zhaoguang Zheng. Scopoletin and umbelliferone from Cortex Mori as protective agents in high glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis. The Chinese journal of physiology. 2021 May; 64(3):150-158. doi: 10.4103/cjp.cjp_9_21. [PMID: 34169921]
  • Chong Yuan, Meng-Heng Wang, Fei Wang, Peng-Yu Chen, Xin-Ge Ke, Bing Yu, Yan-Fang Yang, Peng-Tao You, He-Zhen Wu. Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer. Life sciences. 2021 Apr; 270(?):119105. doi: 10.1016/j.lfs.2021.119105. [PMID: 33497736]
  • Aaro Jalkanen, Veera Lassheikki, Tommi Torsti, Elham Gharib, Marko Lehtonen, Risto O Juvonen. Tissue and interspecies comparison of catechol-O-methyltransferase mediated catalysis of 6-O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Mar; 51(3):268-278. doi: 10.1080/00498254.2020.1853850. [PMID: 33289420]
  • Rafaliya Rutul V, Sakure Amar A, Parekh Mithil J, Sushil K, Amarjeet Singh S T, Desai Parth J, Patil Ghanshyam B, Mistri Jigar G, Subhash N. Study of dynamics of genes involved in biosynthesis and accumulation of scopoletin at different growth stages of Convolvulus prostratus Forssk. Phytochemistry. 2021 Feb; 182(?):112594. doi: 10.1016/j.phytochem.2020.112594. [PMID: 33341029]
  • QianQian Zhuang, Shaopeng Chen, ZhiXin Jua, Yue Yao. Joint transcriptomic and metabolomic analysis reveals the mechanism of low-temperature tolerance in Hosta ventricosa. PloS one. 2021; 16(11):e0259455. doi: 10.1371/journal.pone.0259455. [PMID: 34731224]
  • Yang-Liu Xia, Jing-Jing Wang, Shi-Yang Li, Yong Liu, Frank J Gonzalez, Ping Wang, Guang-Bo Ge. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorganic & medicinal chemistry. 2021 01; 29(?):115851. doi: 10.1016/j.bmc.2020.115851. [PMID: 33218896]
  • Dai Chuan Tan, Alexandra Quek, Nur Kartinee Kassim, Intan Safinar Ismail, Joanna Jinling Lee. Rapid Quantification and Validation of Biomarker Scopoletin in Paederia foetida by qNMR and UV-Vis for Herbal Preparation. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215162. [PMID: 33171900]
  • Theodora K Kowa, Lauve R Y Tchokouaha, Ewa Cieckiewicz, Trudy Janice Philips, Eunice Dotse, Hippolyte K Wabo, Alembert T Tchinda, Pierre Tane, Michel Frédérich. Antileishmanial and cytotoxic activities of a new limonoid and a new phenyl alkene from the stem bark of Trichilia gilgiana (Meliaceae). Natural product research. 2020 Nov; 34(22):3182-3188. doi: 10.1080/14786419.2018.1553879. [PMID: 30663371]
  • Wang Ren, Yantang Wang, Qinhui He, Yue Zhou, Chunxin Li, Wenling Wang, Xiao Leng, Ting Zeng, Qiang Zou, Limei Li. Chemical composition of Erycibe schmidtii and antiproliferative activity of scopoletin on immature dendritic cells. Natural product research. 2020 Sep; 34(18):2581-2588. doi: 10.1080/14786419.2018.1547292. [PMID: 30661400]
  • Xiao-Feng Ma, Yuan-Yuan Zhang, Fu-You Guo, Jin-Xiang Luo, Wei Ding, Yong-Qiang Zhang. Molecular characterization of a voltage-gated calcium channel and its potential role in the acaricidal action of scopoletin against Tetranychus cinnabarinus. Pesticide biochemistry and physiology. 2020 Sep; 168(?):104618. doi: 10.1016/j.pestbp.2020.104618. [PMID: 32711759]
  • Yingchun Zeng, Yu Ma, Zhengyu Yang, Jiamin Mao, Yaxin Zheng. Antihyperuricemic efficacy of Scopoletin-loaded Soluplus micelles in yeast extract/potassium oxonate-induced hyperuricemic mice. Drug development and industrial pharmacy. 2020 Sep; 46(9):1550-1557. doi: 10.1080/03639045.2020.1811302. [PMID: 32811191]
  • Wei Zhang, Lihui Jiang, Jin Huang, Yongqiang Ding, Zhibin Liu. Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis. Plant science : an international journal of experimental plant biology. 2020 Jul; 296(?):110472. doi: 10.1016/j.plantsci.2020.110472. [PMID: 32540002]
  • Jade Serrano-Román, Pilar Nicasio-Torres, Elizabeth Hernández-Pérez, Enrique Jiménez-Ferrer. Elimination pharmacokinetics of sphaeralcic acid, tomentin and scopoletin mixture from a standardized fraction of Sphaeralcea angustifolia (Cav.) G. Don orally administered. Journal of pharmaceutical and biomedical analysis. 2020 May; 183(?):113143. doi: 10.1016/j.jpba.2020.113143. [PMID: 32045824]
  • June Hyuk Jang, Jae Eun Park, Ji Sook Han. Scopoletin increases glucose uptake through activation of PI3K and AMPK signaling pathway and improves insulin sensitivity in 3T3-L1 cells. Nutrition research (New York, N.Y.). 2020 02; 74(?):52-61. doi: 10.1016/j.nutres.2019.12.003. [PMID: 31945607]
  • Sourav Das, Lilla Czuni, Viktória Báló, Gábor Papp, Zoltán Gazdag, Nóra Papp, Tamás Kőszegi. Cytotoxic Action of Artemisinin and Scopoletin on Planktonic Forms and on Biofilms of Candida Species. Molecules (Basel, Switzerland). 2020 Jan; 25(3):. doi: 10.3390/molecules25030476. [PMID: 31979177]
  • Sunayna Choudhary, Indu Pal Kaur, Jai Malik. Development and Validation of a Novel, Rapid Gradient HPLC Method for Simultaneous Estimation of Bioactive Marker Compounds in a Mixture of Convolvulus pluricaulis, Withania somnifera and Bacopa monnieri Extracts. Journal of chromatographic science. 2020 Jan; 57(10):920-930. doi: 10.1093/chromsci/bmz075. [PMID: 31644789]
  • Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer. Bioorganic & medicinal chemistry. 2020 01; 28(1):115180. doi: 10.1016/j.bmc.2019.115180. [PMID: 31784199]
  • Sarita Singh, Karishma Agarwal, Hina Iqbal, Pankaj Yadav, Deepika Yadav, Debabrata Chanda, Sudeep Tandon, Feroz Khan, Anil Kumar Gupta, Atul Gupta. Synthesis and evaluation of substituted 8,8-dimethyl-8H-pyrano[2,3-f]chromen-2-one derivatives as vasorelaxing agents. Bioorganic & medicinal chemistry letters. 2020 01; 30(1):126759. doi: 10.1016/j.bmcl.2019.126759. [PMID: 31711783]
  • Xiaofeng Ma, Yuanyuan Zhang, Hong Zhou, Jinlin Liu, Fuyou Guo, Jinxiang Luo, Wei Ding, Yongqiang Zhang. Silencing T-type voltage-gated calcium channel gene reduces the sensitivity of Tetranychus cinnabarinus (Boisduval) to scopoletin. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2020 Jan; 227(?):108644. doi: 10.1016/j.cbpc.2019.108644. [PMID: 31669662]
  • Ji-Hoon Kang, Kyung Bin Song. Antibacterial activity of the noni fruit extract against Listeria monocytogenes and its applicability as a natural sanitizer for the washing of fresh-cut produce. Food microbiology. 2019 Dec; 84(?):103260. doi: 10.1016/j.fm.2019.103260. [PMID: 31421758]
  • Bo Li, Min Lu, Zixuan Chu, Shanshan Lei, Peilu Sun, Shan Xiong, Suhong Chen. Evaluation of pharmacokinetics, bioavailability and urinary excretion of scopolin and its metabolite scopoletin in Sprague Dawley rats by liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2019 Dec; 33(12):e4678. doi: 10.1002/bmc.4678. [PMID: 31412148]
  • Dai Chuan Tan, Ku Idayu Idris, Nur Kartinee Kassim, Pei Cee Lim, Intan Safinar Ismail, Muhajir Hamid, Rou Chian Ng. Comparative study of the antidiabetic potential of Paederia foetida twig extracts and compounds from two different locations in Malaysia. Pharmaceutical biology. 2019 Dec; 57(1):345-354. doi: 10.1080/13880209.2019.1610462. [PMID: 31185767]
  • Ruben Vanholme, Lisa Sundin, Keletso Carol Seetso, Hoon Kim, Xinyu Liu, Jin Li, Barbara De Meester, Lennart Hoengenaert, Geert Goeminne, Kris Morreel, Jurgen Haustraete, Huei-Hsuan Tsai, Wolfgang Schmidt, Bartel Vanholme, John Ralph, Wout Boerjan. COSY catalyses trans-cis isomerization and lactonization in the biosynthesis of coumarins. Nature plants. 2019 10; 5(10):1066-1075. doi: 10.1038/s41477-019-0510-0. [PMID: 31501530]
  • Armando Zarrelli, Antonino Pollio, Serena Aceto, Valeria Romanucci, Francesca Carella, Paolo Stefani, Antonino De Natale, Gionata De Vico. Optimisation of artemisinin and scopoletin extraction from Artemisia annua with a new modern pressurised cyclic solid-liquid (PCSL) extraction technique. Phytochemical analysis : PCA. 2019 Sep; 30(5):564-571. doi: 10.1002/pca.2853. [PMID: 31238388]
  • Gokhan Zengin, Mehmet Yavuz Paksoy, Muhammad Zakariyyah Aumeeruddy, Jasmina Glamocilja, Marina Sokovic, Alina Diuzheva, József Jekő, Zoltán Cziáky, Maria João Rodrigues, Luisa Custodio, Mohamad Fawzi Mahomoodally. New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species. Food research international (Ottawa, Ont.). 2019 09; 123(?):414-424. doi: 10.1016/j.foodres.2019.05.013. [PMID: 31284993]
  • Tie Liu, Xin-Ge Li, Ji-Ye Wang, De-Long Liu, Yong-Ju Wei. Time-resolved fluorescence and chemometrics-assisted excitation-emission fluorescence for qualitative and quantitative analysis of scopoletin and scopolin in Erycibe obtusifolia Benth. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 Aug; 219(?):96-103. doi: 10.1016/j.saa.2019.04.019. [PMID: 31030053]
  • Lyza Maron. New strategies in the arms race against soybean rust. The Plant journal : for cell and molecular biology. 2019 08; 99(3):395-396. doi: 10.1111/tpj.14464. [PMID: 31348597]
  • Sebastian F Beyer, Alexander Beesley, Philipp F W Rohmann, Holger Schultheiss, Uwe Conrath, Caspar J G Langenbach. The Arabidopsis non-host defence-associated coumarin scopoletin protects soybean from Asian soybean rust. The Plant journal : for cell and molecular biology. 2019 08; 99(3):397-413. doi: 10.1111/tpj.14426. [PMID: 31148306]
  • Yinzi Yue, Li Zeng, Xiaopeng Wang, Lianlin Su, Mingming Sun, Bensheng Wu, Shuai Yan. Loading of AgNPs onto the surface of boron nitride nanosheets for determination of scopoletin in Atractylodes macrocephala. Scientific reports. 2019 03; 9(1):3864. doi: 10.1038/s41598-019-40511-y. [PMID: 30846798]
  • Ya-Xin Zhao, Meng Wang, Wan-Ting Dong, Yang Li. Pharmacokinetics, bioavailability and metabolism of scopoletin in dog by ultra-high-performance liquid chromatography combined with linear ion trap-Orbitrap tandem mass spectrometry. Biomedical chromatography : BMC. 2019 Mar; 33(3):e4436. doi: 10.1002/bmc.4436. [PMID: 30421792]
  • Hui Liu, Rui-Xue Xu, Xiao-Shuang Zhang, Ting-Ting Zhu, Hong-Xiang Lou, Ai-Xia Cheng. The identification and functional characterization of three liverwort class I O-methyltransferases. Phytochemistry. 2019 Mar; 159(?):190-198. doi: 10.1016/j.phytochem.2018.12.001. [PMID: 30634081]
  • Natividad Giovana De La Cruz-Sánchez, Abraham Gómez-Rivera, Patricia Alvarez-Fitz, Elsa Ventura-Zapata, Ma Dolores Pérez-García, Margarita Avilés-Flores, Ana Silvia Gutiérrez-Román, Manasés González-Cortazar. Antibacterial activity of Morinda citrifolia Linneo seeds against Methicillin-Resistant Staphylococcus spp. Microbial pathogenesis. 2019 Mar; 128(?):347-353. doi: 10.1016/j.micpath.2019.01.030. [PMID: 30682527]
  • Wan NurFarahin Wan Osman, Nur Adeelah Che Ahmad Tantowi, Seng Fong Lau, Suhaila Mohamed. Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti-inflammatory, anti-oxidative, and anti-protease pathways. Journal of food biochemistry. 2019 03; 43(3):e12755. doi: 10.1111/jfbc.12755. [PMID: 31353568]
  • Kalaivanan Kalpana, Chandrasekaran Sathiya Priya, Nanda Dipti, Ramachandran Vidhya, Carani Venkatraman Anuradha. Supplementation of scopoletin improves insulin sensitivity by attenuating the derangements of insulin signaling through AMPK. Molecular and cellular biochemistry. 2019 Mar; 453(1-2):65-78. doi: 10.1007/s11010-018-3432-7. [PMID: 30145644]
  • Hipólita Lagunas-Herrera, Jaime Tortoriello, Maribel Herrera-Ruiz, Gabriela Belen Martínez-Henández, Alejandro Zamilpa, Lucía Aguilar Santamaría, Mario García Lorenzana, Galia Lombardo-Earl, Enrique Jiménez-Ferrer. Acute and Chronic Antihypertensive Effect of Fractions, Tiliroside and Scopoletin from Malva parviflora. Biological & pharmaceutical bulletin. 2019; 42(1):18-25. doi: 10.1248/bpb.b18-00355. [PMID: 30606987]
  • Armelle Tontsa Tsamo, Raduis Melong, Pierre Mkounga, Augustin Ephrem Nkengfack. Rubescins I and J, further limonoid derivatives from the stem bark of Trichilia rubescens (Meliaceae). Natural product research. 2019 Jan; 33(2):196-203. doi: 10.1080/14786419.2018.1443087. [PMID: 29502449]
  • Jingkun Liu, Min Xie, Xiuzhuang Li, Hui Jin, Xiaoyan Yang, Zhiqiang Yan, Anxiang Su, Bo Qin. Main Allelochemicals from the Rhizosphere Soil of Saussurea lappa (Decne.) Sch. Bip. and Their Effects on Plants' Antioxidase Systems. Molecules (Basel, Switzerland). 2018 Sep; 23(10):. doi: 10.3390/molecules23102506. [PMID: 30274332]
  • Janine Naß, Thomas Efferth. The activity of Artemisia spp. and their constituents against Trypanosomiasis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Aug; 47(?):184-191. doi: 10.1016/j.phymed.2018.06.002. [PMID: 30166103]
  • Nuramalee Deenamo, Arnannit Kuyyogsuy, Khemmikar Khompatara, Thitikorn Chanwun, Kitiya Ekchaweng, Nunta Churngchow. Salicylic Acid Induces Resistance in Rubber Tree against Phytophthora palmivora. International journal of molecular sciences. 2018 Jun; 19(7):. doi: 10.3390/ijms19071883. [PMID: 29949940]
  • Ioannis A Stringlis, Ke Yu, Kirstin Feussner, Ronnie de Jonge, Sietske Van Bentum, Marcel C Van Verk, Roeland L Berendsen, Peter A H M Bakker, Ivo Feussner, Corné M J Pieterse. MYB72-dependent coumarin exudation shapes root microbiome assembly to promote plant health. Proceedings of the National Academy of Sciences of the United States of America. 2018 05; 115(22):E5213-E5222. doi: 10.1073/pnas.1722335115. [PMID: 29686086]
  • Jakub Rajniak, Ricardo F H Giehl, Evelyn Chang, Irene Murgia, Nicolaus von Wirén, Elizabeth S Sattely. Biosynthesis of redox-active metabolites in response to iron deficiency in plants. Nature chemical biology. 2018 05; 14(5):442-450. doi: 10.1038/s41589-018-0019-2. [PMID: 29581584]
  • Huei-Hsuan Tsai, Jorge Rodríguez-Celma, Ping Lan, Yu-Ching Wu, Isabel Cristina Vélez-Bermúdez, Wolfgang Schmidt. Scopoletin 8-Hydroxylase-Mediated Fraxetin Production Is Crucial for Iron Mobilization. Plant physiology. 2018 05; 177(1):194-207. doi: 10.1104/pp.18.00178. [PMID: 29559590]
  • George Leema, Ramasamy Tamizhselvi. Protective Effect of Scopoletin Against Cerulein-Induced Acute Pancreatitis and Associated Lung Injury in Mice. Pancreas. 2018 May; 47(5):577-585. doi: 10.1097/mpa.0000000000001034. [PMID: 29595543]
  • Jinxiang Luo, Ting Lai, Tao Guo, Fei Chen, Linli Zhang, Wei Ding, Yongqiang Zhang. Synthesis and Acaricidal Activities of Scopoletin Phenolic Ether Derivatives: QSAR, Molecular Docking Study and in Silico ADME Predictions. Molecules (Basel, Switzerland). 2018 Apr; 23(5):. doi: 10.3390/molecules23050995. [PMID: 29695088]
  • Joanna Siwinska, Kinga Siatkowska, Alexandre Olry, Jeremy Grosjean, Alain Hehn, Frederic Bourgaud, Andrew A Meharg, Manus Carey, Ewa Lojkowska, Anna Ihnatowicz. Scopoletin 8-hydroxylase: a novel enzyme involved in coumarin biosynthesis and iron-deficiency responses in Arabidopsis. Journal of experimental botany. 2018 03; 69(7):1735-1748. doi: 10.1093/jxb/ery005. [PMID: 29361149]
  • Claudio Parra, Emilio Soto, Gloria León, Cristian O Salas, Michael Heinrich, Carlos Echiburú-Chau. Nutritional composition, antioxidant activity and isolation of scopoletin from Senecio nutans: support of ancestral and new uses. Natural product research. 2018 Mar; 32(6):719-722. doi: 10.1080/14786419.2017.1335726. [PMID: 28587480]
  • Anam Fayyaz, Seddy Makwinja, Seppo Auriola, Hannu Raunio, Risto O Juvonen. Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals. Planta medica. 2018 Mar; 84(5):320-328. doi: 10.1055/s-0043-119886. [PMID: 28950382]
  • Hyo Hee Yang, Kyung-Eon Oh, Yang Hee Jo, Jong Hoon Ahn, Qing Liu, Ayman Turk, Jae Young Jang, Bang Yeon Hwang, Ki Yong Lee, Mi Kyeong Lee. Characterization of tyrosinase inhibitory constituents from the aerial parts of Humulus japonicus using LC-MS/MS coupled online assay. Bioorganic & medicinal chemistry. 2018 01; 26(2):509-515. doi: 10.1016/j.bmc.2017.12.011. [PMID: 29254897]
  • Ra-Yeong Choi, Ju Ri Ham, Hae-In Lee, Hyun Wook Cho, Myung-Sook Choi, Seok-Kyu Park, Jin Lee, Myung-Joo Kim, Kwon-Il Seo, Mi-Kyung Lee. Scopoletin Supplementation Ameliorates Steatosis and Inflammation in Diabetic Mice. Phytotherapy research : PTR. 2017 Nov; 31(11):1795-1804. doi: 10.1002/ptr.5925. [PMID: 28921708]
  • Elisa Graña, Aitana Costas-Gil, Sabela Longueira, María Celeiro, Marta Teijeira, Manuel J Reigosa, Adela M Sánchez-Moreiras. Auxin-like effects of the natural coumarin scopoletin on Arabidopsis cell structure and morphology. Journal of plant physiology. 2017 Nov; 218(?):45-55. doi: 10.1016/j.jplph.2017.07.007. [PMID: 28772153]
  • Rong-Rong You, Xue-Qing Chen, Dan-Dan He, Chang-Gao Huang, Yang Jin, Shi-Hui Qian, Jian-Ming Ju, Jun-Ting Fan. [Chemical constituents from petroleum ether fraction of Swertia chirayita and their activities in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Oct; 42(19):3764-3769. doi: 10.19540/j.cnki.cjcmm.20170807.003. [PMID: 29235293]
  • William R Chezem, Altamash Memon, Fu-Shuang Li, Jing-Ke Weng, Nicole K Clay. SG2-Type R2R3-MYB Transcription Factor MYB15 Controls Defense-Induced Lignification and Basal Immunity in Arabidopsis. The Plant cell. 2017 Aug; 29(8):1907-1926. doi: 10.1105/tpc.16.00954. [PMID: 28733420]
  • Qiu-Li Hou, Jin-Xiang Luo, Bing-Chuan Zhang, Gao-Fei Jiang, Wei Ding, Yong-Qiang Zhang. 3D-QSAR and Molecular Docking Studies on the TcPMCA1-Mediated Detoxification of Scopoletin and Coumarin Derivatives. International journal of molecular sciences. 2017 Jun; 18(7):. doi: 10.3390/ijms18071380. [PMID: 28653986]
  • Ruijie He, Yanjun Zhang, Liangdeng Wu, Hui Nie, Yan Huang, Buming Liu, Shengping Deng, Ruiyun Yang, Shuai Huang, Zhijie Nong, Jun Li, Haiyan Chen. Benzofuran glycosides and coumarins from the bark of Streblus indicus (Bur.) Corner. Phytochemistry. 2017 Jun; 138(?):170-177. doi: 10.1016/j.phytochem.2017.01.011. [PMID: 28284566]
  • Baptiste Genot, Julien Lang, Souha Berriri, Marie Garmier, Françoise Gilard, Stéphanie Pateyron, Katrien Haustraete, Dominique Van Der Straeten, Heribert Hirt, Jean Colcombet. Constitutively Active Arabidopsis MAP Kinase 3 Triggers Defense Responses Involving Salicylic Acid and SUMM2 Resistance Protein. Plant physiology. 2017 06; 174(2):1238-1249. doi: 10.1104/pp.17.00378. [PMID: 28400495]
  • Shi Liu, Ima M Zainuddin, Herve Vanderschuren, James Doughty, John R Beeching. RNAi inhibition of feruloyl CoA 6'-hydroxylase reduces scopoletin biosynthesis and post-harvest physiological deterioration in cassava (Manihot esculenta Crantz) storage roots. Plant molecular biology. 2017 May; 94(1-2):185-195. doi: 10.1007/s11103-017-0602-z. [PMID: 28315989]
  • Ying-Chun Zeng, Sha Li, Chang Liu, Tao Gong, Xun Sun, Yao Fu, Zhi-Rong Zhang. Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo. Acta pharmacologica Sinica. 2017 Mar; 38(3):424-433. doi: 10.1038/aps.2016.126. [PMID: 28112183]
  • Li Wang, Hai-Long Wu, Xiao-Li Yin, Yong Hu, Hui-Wen Gu, Ru-Qin Yu. Simultaneous determination of umbelliferone and scopoletin in Tibetan medicine Saussurea laniceps and traditional Chinese medicine Radix angelicae pubescentis using excitation-emission matrix fluorescence coupled with second-order calibration method. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2017 Jan; 170(?):104-10. doi: 10.1016/j.saa.2016.07.018. [PMID: 27423108]