Coumarin (BioDeep_00000397992)

Main id: BioDeep_00000000093

Secondary id: BioDeep_00000402536, BioDeep_00000859650

natural product PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


2H-1-Benzopyran-2-one

化学式: C9H6O2 (146.0368)
中文名称: 香豆素, 2H-1-苯并吡喃-2-酮
谱图信息: 最多检出来源 Homo sapiens(otcml) 10.51%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=CC(=O)O2
InChI: InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H

描述信息

Coumarin, also known as 1,2-benzopyrone or benzo-alpha-pyrone, belongs to coumarins and derivatives class of compounds. Those are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one). Coumarin is slightly soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Coumarin is a sweet, green, and new mown hay tasting compound and can be found in a number of food items such as malus (crab apple), sunburst squash (pattypan squash), european cranberry, and star anise, which makes coumarin a potential biomarker for the consumption of these food products. Coumarin can be found primarily in saliva. Coumarin is formally rated as an unfounded non-carcinogenic (IARC 3) potentially toxic compound. Coumarin was first synthesized in 1868. It is used in the pharmaceutical industry as a precursor reagent in the synthesis of a number of synthetic anticoagulant pharmaceuticals similar to dicoumarol, the notable ones being warfarin (brand name Coumadin) and some even more potent rodenticides that work by the same anticoagulant mechanism. 4-hydroxycoumarins are a type of vitamin K antagonist. Pharmaceutical (modified) coumarins were all developed from the study of sweet clover disease; see warfarin for this history. However, unmodified coumarin itself, as it occurs in plants, has no effect on the vitamin K coagulation system, or on the action of warfarin-type drugs .
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2337
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.657
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.654
IPB_RECORD: 3881; CONFIDENCE confident structure
Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.
Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.

同义名列表

4 个代谢物同义名

Coumarin; 2H-1-Benzopyran-2-one; Coumarin; Coumarin



数据库引用编号

68 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(7)

BioCyc(2)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

117 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ABCB1, ALB, ANXA5, CYP1A1, CYP2C9, CYP2E1, CYP3A4, CYP4F2, HPGDS, MAPK14, MTOR, NOS2
Peripheral membrane protein 5 ANXA5, CYP1A1, CYP2E1, CYP4F2, MTOR
Endoplasmic reticulum membrane 8 CYP19A1, CYP1A1, CYP2C9, CYP2E1, CYP3A4, CYP4F2, MTOR, VKORC1
Nucleus 4 ALB, MAPK14, MTOR, NOS2
cytosol 7 ALB, ANXA5, GPT, HPGDS, MAPK14, MTOR, NOS2
dendrite 2 MAOB, MTOR
phagocytic vesicle 1 MTOR
centrosome 1 ALB
nucleoplasm 5 ATP2B1, HPGDS, MAPK14, MTOR, NOS2
Cell membrane 3 ABCB1, ATP2B1, TNF
Cytoplasmic side 2 MAOB, MTOR
Multi-pass membrane protein 4 ABCB1, ATP2B1, CYP19A1, VKORC1
Golgi apparatus membrane 1 MTOR
Synapse 1 ATP2B1
cell surface 2 ABCB1, TNF
glutamatergic synapse 2 ATP2B1, MAPK14
Golgi apparatus 1 ALB
Golgi membrane 1 MTOR
lysosomal membrane 2 GAA, MTOR
mitochondrial inner membrane 2 CYP1A1, CYP2E1
neuronal cell body 2 MAOB, TNF
presynaptic membrane 1 ATP2B1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 NOS2
Lysosome 2 GAA, MTOR
plasma membrane 7 ABCB1, ATP2B1, CYP2C9, F2, GAA, NOS2, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ABCB1, ANXA5, ATP2B1, CYP19A1, CYP3A4, CYP4F2, GAA, MTOR
apical plasma membrane 2 ABCB1, CYP4F2
basolateral plasma membrane 1 ATP2B1
extracellular exosome 7 ABCB1, ALB, ANXA5, ATP2B1, F2, GAA, GPT
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 3 ALB, CYP19A1, VKORC1
extracellular space 3 ALB, F2, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 NOS2
mitochondrion 3 CYP1A1, MAOB, MAPK14
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 8 ATP2B1, CYP1A1, CYP2C9, CYP2E1, CYP3A4, CYP4F2, GAA, HPGDS
Microsome membrane 7 CYP19A1, CYP1A1, CYP2C9, CYP2E1, CYP3A4, CYP4F2, MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 3 ALB, F2, GAA
extracellular region 6 ALB, ANXA5, F2, GAA, MAPK14, TNF
Mitochondrion outer membrane 2 MAOB, MTOR
mitochondrial outer membrane 2 MAOB, MTOR
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 ANXA5, TNF
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 NOS2
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
Membrane raft 1 TNF
focal adhesion 1 ANXA5
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 2 ANXA5, F2
lateral plasma membrane 1 ATP2B1
nuclear speck 1 MAPK14
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 ALB
cell projection 1 ATP2B1
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 2 ALB, MAPK14
blood microparticle 2 ALB, F2
Basolateral cell membrane 1 ATP2B1
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
tertiary granule membrane 1 GAA
Presynaptic cell membrane 1 ATP2B1
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 ALB, F2
platelet alpha granule lumen 1 ALB
azurophil granule membrane 1 GAA
mitochondrial envelope 1 MAOB
immunological synapse 1 ATP2B1
Single-pass type IV membrane protein 1 MAOB
vesicle membrane 1 ANXA5
ficolin-1-rich granule membrane 1 GAA
external side of apical plasma membrane 1 ABCB1
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
photoreceptor ribbon synapse 1 ATP2B1
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Kaiyue Liu, Fuliang Song, Jie Wang, Xingrui Wang, Chun Kan. A V-shaped bis-coumarin based fluorescence probe for F- detection in tea infusions and potable water and bioimaging applications in living systems. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2024 Aug; 316(?):124349. doi: 10.1016/j.saa.2024.124349. [PMID: 38692107]
  • Fahed A Aloufi, Hamada AbdElgawad, Riyadh F Halawani, Mansour A Balkhyour, Abdelrahim H A Hassan. Selenium nanoparticles induce coumarin metabolism and essential oil production in Trachyspermum ammi under future climate CO2 conditions. Plant physiology and biochemistry : PPB. 2024 Jun; 211(?):108705. doi: 10.1016/j.plaphy.2024.108705. [PMID: 38714128]
  • Megan DeLoose, Huikyong Cho, Nadia Bouain, Ilyeong Choi, Chanakan Prom-U-Thai, Zaigham Shahzad, Luqing Zheng, Hatem Rouached. PDR9 allelic variation and MYB63 modulate nutrient-dependent coumarin homeostasis in Arabidopsis. The Plant journal : for cell and molecular biology. 2024 Mar; 117(6):1716-1727. doi: 10.1111/tpj.16678. [PMID: 38361338]
  • Sunbula Atolikshoeva, Jun Li, Jiangyu Zhao, Sodik Numonov, Haji Akber Aisa. New coumarin from the roots of Prangos pabularia growing wild in Tajikistan. Natural product research. 2024 Jan; 38(1):1-9. doi: 10.1080/14786419.2022.2102627. [PMID: 35895127]
  • Vanessa Paffrath, Yudelsy A Tandron Moya, Günther Weber, Nicolaus von Wirén, Ricardo F H Giehl. A major role of coumarin-dependent ferric iron reduction in strategy I-type iron acquisition in Arabidopsis. The Plant cell. 2023 Nov; ?(?):. doi: 10.1093/plcell/koad279. [PMID: 38016103]
  • Alexander Beesley, Sebastian F Beyer, Verena Wanders, Sophie Levecque, Sandra Bredenbruch, Samer S Habash, A Sylvia S Schleker, Jochem Gätgens, Marco Oldiges, Holger Schultheiss, Uwe Conrath, Caspar J G Langenbach. Engineered coumarin accumulation reduces mycotoxin-induced oxidative stress and disease susceptibility. Plant biotechnology journal. 2023 Aug; ?(?):. doi: 10.1111/pbi.14144. [PMID: 37578146]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Seol Jang, Ami Lee, Youn-Hwan Hwang. Chemical Profile Determination and Quantitative Analysis of Components in Oryeong-san Using UHPLC-Q-Orbitrap-MS and UPLC-TQ-MS/MS. Molecules (Basel, Switzerland). 2023 Apr; 28(9):. doi: 10.3390/molecules28093685. [PMID: 37175095]
  • Yerlan M Suleimen, Rani A Jose, Raigul N Suleimen, Margarita Y Ishmuratova, Suzanne Toppet, Wim Dehaen, Aisha A Alsfouk, Eslam B Elkaeed, Ibrahim H Eissa, Ahmed M Metwaly. Isolation and In Silico SARS-CoV-2 Main Protease Inhibition Potential of Jusan Coumarin, a New Dicoumarin from Artemisia glauca. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072281. [PMID: 35408682]
  • Fanxin Zeng, Tao Lu, Jie Wang, Xuliang Nie, Wanming Xiong, Zhongping Yin, Dayong Peng. Design, Synthesis and Bioactivity Evaluation of Coumarin-BMT Hybrids as New Acetylcholinesterase Inhibitors. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072142. [PMID: 35408542]
  • Wanjun Gong, Lingdong Jiang, Yanxia Zhu, Mengna Jiang, Danyang Chen, Zhaokui Jin, Shucun Qin, Zhiqiang Yu, Qianjun He. An Activity-Based Ratiometric Fluorescent Probe for In Vivo Real-Time Imaging of Hydrogen Molecules. Angewandte Chemie (International ed. in English). 2022 02; 61(9):e202114594. doi: 10.1002/anie.202114594. [PMID: 34921480]
  • Yanyan Zhao, Wen Shi, Xiaohua Li, Huimin Ma. Recent advances in fluorescent probes for lipid droplets. Chemical communications (Cambridge, England). 2022 Feb; 58(10):1495-1509. doi: 10.1039/d1cc05717k. [PMID: 35019910]
  • Jeelan Basha Shaik, Yelamanda Rao Kandrakonda, Monika Kallubai, Navya Naidu Gajula, Shreya Dubey, Bindu Madhava Reddy Aramati, Rajagopal Subramanyam, Gangaiah Damu Amooru. Deciphering the AChE-binding mechanism with multifunctional tricyclic coumarin anti-Alzheimer's agents using biophysical and bioinformatics approaches and evaluation of their modulating effect on Amyloidogenic peptide assembly. International journal of biological macromolecules. 2021 Dec; 193(Pt B):1409-1420. doi: 10.1016/j.ijbiomac.2021.10.204. [PMID: 34740688]
  • Meiling Luo, Qiao Li, Ping Shen, Shengli Hu, Junyu Wang, Zhou Wu, Zhenhong Su. Coumarin 1,4-enedione for selective detection of hydrazine in aqueous solution and fluorescence imaging in living cells. Analytical and bioanalytical chemistry. 2021 Dec; 413(30):7541-7548. doi: 10.1007/s00216-021-03719-4. [PMID: 34783881]
  • Lei Liu, Li-Peng Shan, Ming-Yang Xue, Jian-Fei Lu, Yang Hu, Guang-Lu Liu, Jiong Chen. Potential application of antiviral coumarin in aquaculture against IHNV infection by reducing viral adhesion to the epithelial cell surface. Antiviral research. 2021 11; 195(?):105192. doi: 10.1016/j.antiviral.2021.105192. [PMID: 34687821]
  • Seyed Jamal Alavi, Amir Zebarjadi, Mahdi Hosseini Bafghi, Hossein Orafai, Hamid Sadeghian. O-prenylated carbostyrils as a novel class of 15-lipoxygenase inhibitors: Synthesis, characterization, and inhibitory assessment. Chemical biology & drug design. 2021 11; 98(5):894-902. doi: 10.1111/cbdd.13944. [PMID: 34453501]
  • Y Fakri Mustafa, R Riyadh Khalil, E Tareq Mohammed, M K Bashir, M Khudhayer Oglah. Effects of Structural Manipulation on the Bioactivity of some Coumarin-Based Products. Archives of Razi Institute. 2021 11; 76(5):1297-1305. doi: 10.22092/ari.2021.356100.1776. [PMID: 35355735]
  • Xuezhe Piao, Hee Sun Byun, So-Ra Lee, Eunjin Ju, Kyeong Ah Park, Kyung-Cheol Sohn, Khong Trong Quan, Jinbae Lee, MinKyun Na, Gang Min Hur. 8-Geranylumbelliferone isolated from Paramignya trimera triggers RIPK1/RIPK3-dependent programmed cell death upon TNFR1 ligation. Biochemical pharmacology. 2021 10; 192(?):114733. doi: 10.1016/j.bcp.2021.114733. [PMID: 34411570]
  • Hui Ren, Wen Yao, Qun Wei, Jun Zhang, BaoXiang Zhao, JunYing Miao. Identification of a new autophagy inhibitor targeting lipid droplets in vascular endothelial cells. Biochemical and biophysical research communications. 2021 09; 571(?):195-200. doi: 10.1016/j.bbrc.2021.07.078. [PMID: 34330064]
  • Julien Ihssen, Greta Faccio, Chunyan Yao, Teja Sirec, Urs Spitz. Fluorogenic in vitro activity assay for the main protease Mpro from SARS-CoV-2 and its adaptation to the identification of inhibitors. STAR protocols. 2021 09; 2(3):100793. doi: 10.1016/j.xpro.2021.100793. [PMID: 34423318]
  • Xiping Xu, Yaru Yan, Wenqian Huang, Ting Mo, Xiaohui Wang, Juan Wang, Jun Li, Shepo Shi, Xiao Liu, Pengfei Tu. Molecular cloning and biochemical characterization of a new coumarin glycosyltransferase CtUGT1 from Cistanche tubulosa. Fitoterapia. 2021 Sep; 153(?):104995. doi: 10.1016/j.fitote.2021.104995. [PMID: 34293438]
  • Zain H Mohamed, Cosima Rhein, Benjamin Schmid, Philipp Tripal, Johannes Kornhuber, Christoph Arenz. Synthesis and characterization of a new two photon excitable acid sphingomyelinase FRET probe. Bioorganic & medicinal chemistry. 2021 08; 44(?):116303. doi: 10.1016/j.bmc.2021.116303. [PMID: 34280850]
  • Isabel Cristina da Costa Araldi, Thiele Piber de Souza, Marina de Souza Vencato, Thainara de Andrade Fortes, Camila Benaduce Emanuelli Mello, Juliana Sorraila de Oliveira, Guilherme Lopes Dornelles, Cinthia Melazzo de Andrade, Roberto Marinho Maciel, Cristiane Cademartori Danesi, Amanda Leitão Gindri, Alencar Kolinski Machado, Liliane de Freitas Bauermann. Preclinical safety assessment of the crude extract from Sida rhombifolia L. aerial parts in experimental models of acute and repeated-dose 28 days toxicity in rats. Regulatory toxicology and pharmacology : RTP. 2021 Aug; 124(?):104974. doi: 10.1016/j.yrtph.2021.104974. [PMID: 34139276]
  • Liqiang Zhao, Shengxiang Zhang, Chunmiao Shan, Yuanyuan Shi, Huan Wu, Jiawen Wu, Daiyin Peng. De novo transcriptome assembly of Angelica dahurica and characterization of coumarin biosynthesis pathway genes. Gene. 2021 Jul; 791(?):145713. doi: 10.1016/j.gene.2021.145713. [PMID: 33979682]
  • Hans Wilhelm Rauwald, Ralf Maucher, Gerd Dannhardt, Kenny Kuchta. Dihydroisocoumarins, Naphthalenes, and Further Polyketides from Aloe vera and A. plicatilis: Isolation, Identification and Their 5-LOX/COX-1 Inhibiting Potency. Molecules (Basel, Switzerland). 2021 Jul; 26(14):. doi: 10.3390/molecules26144223. [PMID: 34299499]
  • Leonardo Bruno, Emanuela Talarico, Luz Cabeiras-Freijanes, Maria Letizia Madeo, Antonella Muto, Marco Minervino, Luigi Lucini, Begoña Miras-Moreno, Adriano Sofo, Fabrizio Araniti. Coumarin Interferes with Polar Auxin Transport Altering Microtubule Cortical Array Organization in Arabidopsis thaliana (L.) Heynh. Root Apical Meristem. International journal of molecular sciences. 2021 Jul; 22(14):. doi: 10.3390/ijms22147305. [PMID: 34298924]
  • Fumika Shii, Dingze Mang, Mayu Kasubuchi, Kana Tsuneto, Tomoko Toyama, Haruka Endo, Ken Sasaki, Ryoichi Sato. Ultrasensitive detection by maxillary palp neurons allows non-host recognition without consumption of harmful allelochemicals. Journal of insect physiology. 2021 07; 132(?):104263. doi: 10.1016/j.jinsphys.2021.104263. [PMID: 34052304]
  • Izabela Perkowska, Marta Potrykus, Joanna Siwinska, Dominika Siudem, Ewa Lojkowska, Anna Ihnatowicz. Interplay between Coumarin Accumulation, Iron Deficiency and Plant Resistance to Dickeya spp. International journal of molecular sciences. 2021 Jun; 22(12):. doi: 10.3390/ijms22126449. [PMID: 34208600]
  • Roman Pavela, Filippo Maggi, Giovanni Benelli. Coumarin (2H-1-benzopyran-2-one): a novel and eco-friendly aphicide. Natural product research. 2021 May; 35(9):1566-1571. doi: 10.1080/14786419.2019.1660334. [PMID: 31507220]
  • Hui Jiang, Jian Liu, Yanling Wang, Leijing Chen, Hui Liu, Zhen Wang, Bin Wang. Screening the Q-markers of TCMs from RA rat plasma using UHPLC-QTOF/MS technique for the comprehensive evaluation of Wu-Wei-Wen-Tong Capsule. Journal of mass spectrometry : JMS. 2021 May; 56(5):e4711. doi: 10.1002/jms.4711. [PMID: 33764633]
  • Tariq Javed, Sarwat Ali Raja, Kashif Ur Rehman, Samrah Khalid, Namrah Khalid, Sana Riaz. In silico bimolecular characterization of anticancer phytochemicals from Fagonia indica. Pakistan journal of pharmaceutical sciences. 2021 May; 34(3):883-889. doi: ". [PMID: 34602410]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Wei Ma, Bing Xu, Ru Sun, Yu-Jie Xu, Jian-Feng Ge. The application of amide units in the construction of neutral functional dyes for mitochondrial staining. Journal of materials chemistry. B. 2021 03; 9(10):2524-2531. doi: 10.1039/d0tb02885a. [PMID: 33659976]
  • Wan Mohd Nuzul Hakimi Wan Salleh, Salam Ahmed Abed, Muhammad Taher, Hakimi Kassim, Alene Tawang. The phytochemistry and biological diversity of Ferulago genus (Apiaceae): a systematic review. The Journal of pharmacy and pharmacology. 2021 Mar; 73(1):1-21. doi: 10.1093/jpp/rgaa034. [PMID: 33791809]
  • Max J J Stassen, Shu-Hua Hsu, Corné M J Pieterse, Ioannis A Stringlis. Coumarin Communication Along the Microbiome-Root-Shoot Axis. Trends in plant science. 2021 02; 26(2):169-183. doi: 10.1016/j.tplants.2020.09.008. [PMID: 33023832]
  • Guo-Yong Huang, Hui Cui, Xin-Yi Lu, Lu-Di Zhang, Xiao-Ying Ding, Jin-Jun Wu, Li-Xin Duan, Shi-Jie Zhang, Zhongqiu Liu, Rong-Rong Zhang. (+/-)-Dievodialetins A-G: Seven pairs of enantiomeric coumarin dimers with anti-acetylcholinesterase activity from the roots of Evodia lepta Merr. Phytochemistry. 2021 Feb; 182(?):112597. doi: 10.1016/j.phytochem.2020.112597. [PMID: 33341030]
  • Kevin Robe, Geneviève Conejero, Fei Gao, Linnka Lefebvre-Legendre, Elodie Sylvestre-Gonon, Valérie Rofidal, Sonia Hem, Nicolas Rouhier, Marie Barberon, Arnaud Hecker, Frédéric Gaymard, Esther Izquierdo, Christian Dubos. Coumarin accumulation and trafficking in Arabidopsis thaliana: a complex and dynamic process. The New phytologist. 2021 02; 229(4):2062-2079. doi: 10.1111/nph.17090. [PMID: 33205512]
  • Tin Myo Thant, Nanik Siti Aminah, Alfinda Novi Kristanti, Rico Ramadhan, Preecha Phuwapraisirisan, Yoshiaki Takaya. A new pyrano coumarin from Clausena excavata roots displaying dual inhibition against α-glucosidase and free radical. Natural product research. 2021 Feb; 35(4):556-561. doi: 10.1080/14786419.2019.1586696. [PMID: 30908081]
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  • Marija R Mandić, Mariana M Oalđe, Tanja M Lunić, Aneta D Sabovljević, Marko S Sabovljević, Uroš M Gašić, Sonja N Duletić-Laušević, Bojan Dj Božić, Biljana Dj Božić Nedeljković. Chemical characterization and in vitro immunomodulatory effects of different extracts of moss Hedwigia ciliata (Hedw.) P. Beauv. from the Vršačke Planine Mts., Serbia. PloS one. 2021; 16(2):e0246810. doi: 10.1371/journal.pone.0246810. [PMID: 33571277]
  • Cu Ean Ong, Rafidah Ahmad, You Keng Goh, Kamalrul Azlan Azizan, Syarul Nataqain Baharum, Kah Joo Goh. Growth modulation and metabolic responses of Ganoderma boninense to salicylic acid stress. PloS one. 2021; 16(12):e0262029. doi: 10.1371/journal.pone.0262029. [PMID: 34972183]
  • Yang-Liu Xia, Jing-Jing Wang, Shi-Yang Li, Yong Liu, Frank J Gonzalez, Ping Wang, Guang-Bo Ge. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorganic & medicinal chemistry. 2021 01; 29(?):115851. doi: 10.1016/j.bmc.2020.115851. [PMID: 33218896]
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