sesamin (BioDeep_00000230030)

Main id: BioDeep_00000002674

Secondary id: BioDeep_00000171568

natural product PANOMIX_OTCML-2023


代谢物信息卡片


1,3-Benzodioxole, 5,5-(tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl)bis-, (1S-(1.alpha.,3a.alpha.,4.alpha.,6a.alpha.))-

化学式: C20H18O6 (354.1103)
中文名称: 细辛脂素, 細辛素, 芝麻素
谱图信息: 最多检出来源 Viridiplantae(natural_products) 21.24%

分子结构信息

SMILES: C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6
InChI: InChI=1S/C20H18O6/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2

描述信息

D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D020011 - Protective Agents > D000975 - Antioxidants
D009676 - Noxae > D000963 - Antimetabolites
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.233
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.236
Asarinin is a natural product found in Piper mullesua, Machilus thunbergii, and other organisms with data available.
(-)-Asarinin is a natural product found in Zanthoxylum austrosinense, Horsfieldia irya, and other organisms with data available.
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2].
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2].

同义名列表

59 个代谢物同义名

1,3-Benzodioxole, 5,5-(tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl)bis-, (1S-(1alpha,3a alpha,4alpha,6a alpha))-; 5-[(1S,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[4,3-c]furan-1-yl]-1,3-benzodioxole; 1H,3H-Furo(3,4-c)furan, tetrahydro-1,4-bis(3,4-(methylenedioxy)phenyl)-, (1S,3aR,4S,6aR)- (8CI); 1,3-Benzodioxole, 5,5-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-, (1S,3aR,4S,6aR)-; D-(+)-Sesamin; ACon0_000323; SMR000445559; MLS000728578; ACon1_002421; AIDS-002473; (+)-Segamin; (+)-Sesamin; S9314_SIGMA; AIDS002473; episesamin; NSC 36403; AI3-00811; 607-80-7; sesamin; Sezamin; C10882; asarinin; 1,3-Benzodioxole, 5,5-(tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl)bis-, (1S-(1.alpha.,3a.alpha.,4.alpha.,6a.alpha.))-; 1, 5,5-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-, [1S-(1.alpha.,3a.alpha.,4.alpha.,6a.alpha.)]-; 1,3-Benzodioxole,5,5-[(1R,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis-, rel-; 5-[6-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole; 5-[3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole; 1H,4-c]furan, tetrahydro-1,4-bis[3,4-(methylenedioxy)phenyl]-, (1S,3aR,4S,6aR)-; 1H,3H-Furo(3,4-c)furan, tetrahydro-1,4-bis(3,4-(methylenedioxy)phenyl)-, (+)-; 1,3-Benzodioxole, 5,5-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-; 1,3-Benzodioxole, 5,5-(tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl)bis-; 1H,4-c]furan, tetrahydro-1,4-bis[3,4-(methylenedioxy)phenyl]-, (+)-; 2,6-Bis(3,4-(methylenedioxy)phenyl)-3,7-dioxabicyclo(3.3.0)octane; 2,6-Bis(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo[3.3.0]octane; sesamin, (1R-(1alpha,3aalpha,4alpha,6aalpha))-isomer; sesamin, (1R-(1alpha,3aalpha,4beta,6aalpha))-isomer; PEYUIKBAABKQKQ-UHFFFAOYSA-N; PSEUDO CUBEBIN; Sesamin, (+)-; NCI60_013439; epi-sesamin; DL-Asarinin; AI3-21201; DESAMIN; 1,3-BENZODIOXOLE, 5,5-(TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1,4-DIYL)BIS-, (1R-(1.ALPHA.,3A.ALPHA.,4.BETA.,6A.ALPHA.))-; 1,3-Benzodioxole, 5,5-(tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl)bis-, (1R-(1alpha,3aalpha,4beta,6aalpha))-; 5-[(3R,3aS,6S,6aS)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole; 1,3-BENZODIOXOLE, 5,5-((1R,3AS,4S,6AS)-TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1,4-DIYL)BIS-; 1,3-Benzodioxole,5,5-[(1R,3aS,4S,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis-; 5,5-[(1R,3aS,4S,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis-1,3-benzodioxole; (1RS,3aRS,4SS,6aRS)-1,4-bis(benzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan; Eleutheroside B4; ASARININ, (-)-; ASARININ [MI]; pseudocubebin; Xanthoxyln S; (-)-Asarinin; l-asarinin; Sesamin



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

815 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 ANG, BCL2, CASP3, CAT, CCND1, CYP2E1, MAPK8, NFE2L2, NOS2, NOS3, PIK3CA, RELA, SIRT1, TH, TP53, VEGFA
Peripheral membrane protein 1 CYP2E1
Endoplasmic reticulum membrane 3 BCL2, CYP2E1, HMOX1
Nucleus 14 ANG, BCL2, CASP3, CCND1, HMOX1, MAPK8, NFE2L2, NOS2, NOS3, RELA, SIRT1, TH, TP53, VEGFA
cytosol 16 ANG, BCL2, CASP3, CAT, CCND1, GPT, HMOX1, MAPK8, NFE2L2, NOS2, NOS3, PIK3CA, RELA, SIRT1, TH, TP53
dendrite 1 TH
centrosome 3 CCND1, NFE2L2, TP53
nucleoplasm 10 CASP3, CCND1, HMOX1, MAPK8, NFE2L2, NOS2, NOS3, RELA, SIRT1, TP53
RNA polymerase II transcription regulator complex 1 NFE2L2
Cytoplasmic side 1 HMOX1
lamellipodium 1 PIK3CA
Cell projection, axon 1 TH
Synapse 1 MAPK8
cell surface 1 VEGFA
glutamatergic synapse 2 CASP3, RELA
Golgi apparatus 3 NFE2L2, NOS3, VEGFA
Golgi membrane 2 INS, NOS3
growth cone 1 ANG
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 2 ANG, CASP3
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Cytoplasm, cytosol 2 NFE2L2, NOS2
plasma membrane 4 NFE2L2, NOS2, NOS3, PIK3CA
terminal bouton 1 TH
Membrane 5 BCL2, CAT, HMOX1, TP53, VEGFA
axon 2 MAPK8, TH
caveola 1 NOS3
extracellular exosome 2 CAT, GPT
endoplasmic reticulum 4 BCL2, HMOX1, TP53, VEGFA
extracellular space 5 ANG, HMOX1, IL6, INS, VEGFA
perinuclear region of cytoplasm 5 HMOX1, NOS2, NOS3, PIK3CA, TH
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CAT, SIRT1, TH, TP53
protein-containing complex 3 BCL2, CAT, TP53
intracellular membrane-bounded organelle 2 CAT, CYP2E1
Microsome membrane 1 CYP2E1
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Secreted 4 ANG, IL6, INS, VEGFA
extracellular region 5 ANG, CAT, IL6, INS, VEGFA
cytoplasmic side of plasma membrane 1 TH
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 2 RELA, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
perikaryon 1 TH
cytoplasmic vesicle 1 TH
nucleolus 3 ANG, SIRT1, TP53
Melanosome membrane 1 TH
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
Cytoplasm, perinuclear region 2 NOS2, TH
Mitochondrion inner membrane 1 CYP2E1
heterochromatin 1 SIRT1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAT
extracellular matrix 1 VEGFA
Peroxisome 2 CAT, NOS2
basement membrane 1 ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Nucleus, PML body 2 SIRT1, TP53
PML body 2 SIRT1, TP53
secretory granule 1 VEGFA
nuclear inner membrane 1 SIRT1
neuron projection 1 TH
chromatin 4 NFE2L2, RELA, SIRT1, TP53
mediator complex 1 NFE2L2
Chromosome 1 ANG
cytoskeleton 1 NOS3
Nucleus, nucleolus 1 ANG
site of double-strand break 1 TP53
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
endosome lumen 1 INS
Cytoplasm, Stress granule 2 ANG, NOS3
cytoplasmic stress granule 2 ANG, NOS3
euchromatin 1 SIRT1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
nuclear matrix 1 TP53
transcription repressor complex 2 CCND1, TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 NOS3
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
cortical cytoskeleton 1 NOS2
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Ya-Ping Bai, Teng Zhang, Zheng-Yan Hu, Yan Zhang, De-Guo Wang, Meng-Yun Zhou, Ying Zhang, Fang Zhang, Xiang Kong. Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo. Biochemical pharmacology. 2024 Jun; 224(?):116240. doi: 10.1016/j.bcp.2024.116240. [PMID: 38679210]
  • Mengyun Dong, Tianliang Zhang, Xueli Liang, Xinyi Cheng, Fuyan Shi, Hang Yuan, Fengxiang Zhang, Qiqi Jiang, Xia Wang. Sesamin alleviates lipid accumulation induced by oleic acid via PINK1/Parkin-mediated mitophagy in HepG2 cells. Biochemical and biophysical research communications. 2024 May; 708(?):149815. doi: 10.1016/j.bbrc.2024.149815. [PMID: 38531220]
  • Maoyuan Zhao, Yueqiang Wen, Yi Yang, Huafeng Pan, Shunkai Xie, Caifei Shen, Wenhao Liao, Nianzhi Chen, Qiao Zheng, Gang Zhang, Yuchen Li, Daoyin Gong, Jianyuan Tang, Ziyi Zhao, Jinhao Zeng. (-)-Asarinin alleviates gastric precancerous lesions by promoting mitochondrial ROS accumulation and inhibiting the STAT3 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155348. doi: 10.1016/j.phymed.2024.155348. [PMID: 38335913]
  • Baining Zhang, Zhiwei He, Jialin Guo, Feng Li, Zhi Huang, Wenkai Zheng, Wenhua Xing, Manglai Li, Yong Zhu, Xuejun Yang. Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation. Aging. 2024 Jan; 16(2):1145-1160. doi: 10.18632/aging.205386. [PMID: 38284902]
  • Shahab Ghaderi, Masome Rashno, Alireza Sarkaki, Seyed Esmaeil Khoshnam. Sesamin mitigates lead-induced behavioral deficits in male rats: The role of oxidative stress. Brain research bulletin. 2024 Jan; 206(?):110852. doi: 10.1016/j.brainresbull.2023.110852. [PMID: 38141790]
  • Nelma Nyvonne Tiqu Gina, Jui-Ling Kuo, Mei-Li Wu, Show-Mei Chuang. Sesamin and sesamolin potentially inhibit adipogenesis through downregulating the peroxisome proliferator-activated receptor γ protein expression and activity in 3T3-L1 cells. Nutrition research (New York, N.Y.). 2023 Dec; 123(?):4-17. doi: 10.1016/j.nutres.2023.12.011. [PMID: 38228077]
  • Shu-Ming Huang, Cheng-Hung Chuang, Christine Joyce F Rejano, Lemmuel L Tayo, Cheng-Yang Hsieh, Steven Kuan-Hua Huang, Po-Wei Tsai. Sesamin: A Promising Therapeutic Agent for Ameliorating Symptoms of Diabetes. Molecules (Basel, Switzerland). 2023 Oct; 28(21):. doi: 10.3390/molecules28217255. [PMID: 37959677]
  • Qian Zeng, Ting-Ting Zhou, Wen-Jie Huang, Xiao-Ting Huang, Lei Huang, Xiao-Hua Zhang, Xiao-Xue Sang, Yu-Yang Luo, Yu-Mei Tian, Bin Wu, Lin Liu, Zi-Qiang Luo, Bin He, Wei Liu, Si-Yuan Tang. Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ. Scientific reports. 2023 09; 13(1):14706. doi: 10.1038/s41598-023-41933-5. [PMID: 37679587]
  • Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Chul Yung Choi, Gil-Saeng Jeong, Sang Ki Lee, Hyung Sik Kim, Hye Gwang Jeong. Sesamin ameliorates lipotoxicity and lipid accumulation through the activation of the estrogen receptor alpha signaling pathway. Biochemical pharmacology. 2023 Aug; 216(?):115768. doi: 10.1016/j.bcp.2023.115768. [PMID: 37652106]
  • Elham Ramazani, Faeze Ebrahimpour, Seyed Ahmad Emami, Abolfazl Shakeri, Behjat Javadi, Amirhossein Sahebkar, Zahra Tayarani-Najaran. Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells. Recent advances in food, nutrition & agriculture. 2023 Aug; ?(?):. doi: 10.2174/2772574x14666230804151124. [PMID: 37539928]
  • Zhao-Jie Wang, Yi-Chi Chen, Feng-Cai Zou, Yan Qin, Yan-Yan Zhu, Xia Xiao, Tian-Zhen Xie, Ying-Jie He, Yun-Li Zhao, Xiao-Dong Luo. Phytochemical Analysis and Anti-Ascaris suum Activity of Different Zanthoxylum Species In Vitro and In Vivo. Journal of agricultural and food chemistry. 2023 Apr; 71(13):5219-5229. doi: 10.1021/acs.jafc.2c08949. [PMID: 36971186]
  • Chao Liang, Chi Ndi, Louise Kjaerulff, Susan Semple, Bevan Buirchell, Sonia Coriani, Birger Lindberg Møller, Dan Staerk. Characterization of Serrulatane Diterpenoids in Eremophila phyllopoda subsp. phyllopoda by Triple High-Resolution α-Glucosidase/PTP1B/Radical Scavenging Profiling, NMR Spectroscopy, DFT-GIAO NMR, and Electronic Circular Dichroism Calculations. Journal of natural products. 2023 Mar; ?(?):. doi: 10.1021/acs.jnatprod.2c00692. [PMID: 36880726]
  • Hui Du, Shiwen Tong, Ge Kuang, Xia Gong, Ningman Jiang, Xian Yang, Hao Liu, Nana Li, Yao Xie, Yang Xiang, Jiashi Guo, Zhenhan Li, Yinglin Yuan, Shengwang Wu, Jingyuan Wan. Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal in Mice. Journal of immunology research. 2023; 2023(?):1116841. doi: 10.1155/2023/1116841. [PMID: 37663051]
  • Satoshi Morita, Hideyuki Sasaki, Yoshihisa Kaneda, Tomohiro Rogi, Takayuki Izumo, Masaaki Nakai. Effects of Combining Docosahexaenoic Acid and Eicosapentaenoic Acid with Sesame Lignan on Vascular Endothelial Function. Journal of nutritional science and vitaminology. 2023; 69(5):370-376. doi: 10.3177/jnsv.69.370. [PMID: 37940577]
  • Jun Yamada, Shoichiro Maeda, Mariko Soya, Hidefumi Nishida, Kyoko M Iinuma, Shozo Jinno. Alleviation of cognitive deficits via upregulation of chondroitin sulfate biosynthesis by lignan sesamin in a mouse model of neuroinflammation. The Journal of nutritional biochemistry. 2022 10; 108(?):109093. doi: 10.1016/j.jnutbio.2022.109093. [PMID: 35724814]
  • Longkai Shi, Emad Karrar, Ruijie Liu, Ming Chang, Xingguo Wang. Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells. Journal of food biochemistry. 2022 08; 46(8):e14180. doi: 10.1111/jfbc.14180. [PMID: 35396857]
  • Qiaoyun Bai, Zhiguang Wang, Yihua Piao, Xiao Zhou, Qinji Piao, Jingzhi Jiang, Hanye Liu, Hongmei Piao, Liangchang Li, Yilan Song, Guanghai Yan. Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis. Journal of agricultural and food chemistry. 2022 Apr; 70(16):4921-4933. doi: 10.1021/acs.jafc.1c07877. [PMID: 35420033]
  • Daiki Oikawa, Satoshi Yamashita, Seiji Takahashi, Toshiyuki Waki, Koichi Kikuchi, Takaaki Abe, Takane Katayama, Toru Nakayama. (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis. Biochemical and biophysical research communications. 2022 01; 590(?):158-162. doi: 10.1016/j.bbrc.2021.12.088. [PMID: 34974305]
  • Sayeh Mottaghi, Hassan Abbaszadeh. A comprehensive mechanistic insight into the dietary and estrogenic lignans, arctigenin and sesamin as potential anticarcinogenic and anticancer agents. Current status, challenges, and future perspectives. Critical reviews in food science and nutrition. 2022; 62(26):7301-7318. doi: 10.1080/10408398.2021.1913568. [PMID: 33905270]
  • Yiting Sun, Jingyi Ren, Siqi Zhu, Zhenao Zhang, Zihao Guo, Jiaqi An, Bowen Yin, Yuxia Ma. The Effects of Sesamin Supplementation on Obesity, Blood Pressure, and Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in endocrinology. 2022; 13(?):842152. doi: 10.3389/fendo.2022.842152. [PMID: 35311241]
  • Haiping He, Tonghua Yang, Fan Li, Lihua Zhang, Xiaosui Ling. A novel study on the immunomodulatory effect of umbilical cord derived mesenchymal stem cells pretreated with traditional Chinese medicine Asarinin. International immunopharmacology. 2021 Nov; 100(?):108054. doi: 10.1016/j.intimp.2021.108054. [PMID: 34492537]
  • Chen Chen, Xinwei Shi, Tao Zhou, Weimin Li, Sifeng Li, Guoqing Bai. Full-length transcriptome analysis and identification of genes involved in asarinin and aristolochic acid biosynthesis in medicinal plant Asarum sieboldii. Genome. 2021 Jun; 64(6):639-653. doi: 10.1139/gen-2020-0095. [PMID: 33320770]
  • Zhao-Yue Dong, Lin Wei, Hui-Qiang Lu, Qing-Hong Zeng, Fan-Cheng Meng, Guo-Wei Wang, Xiao-Zhong Lan, Zhi-Hua Liao, Min Chen. Ptehoosines A and B: Two new sesamin-type sesquilignans with antiangiogenic activity from Pterocephalus hookeri (C.B. Clarke) Höeck. Fitoterapia. 2021 Jun; 151(?):104886. doi: 10.1016/j.fitote.2021.104886. [PMID: 33757847]
  • Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee. Simultaneous determination of asarinin, β-eudesmol, and wogonin in rats using ultraperformance liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies following administration of standards and Gumiganghwal-tang. Biomedical chromatography : BMC. 2021 Apr; 35(4):e5021. doi: 10.1002/bmc.5021. [PMID: 33169364]
  • Mengxi Wang, Pan Liu, Lingyan Kong, Na Xu, Hong Lei. Promotive effects of sesamin on proliferation and adhesion of intestinal probiotics and its mechanism of action. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Mar; 149(?):112049. doi: 10.1016/j.fct.2021.112049. [PMID: 33561518]
  • Yilin Wang, Jin Wen, Marwan Almoiliqy, Yaojia Wang, Zhihao Liu, Xiaobo Yang, Xiaolong Lu, Qiang Meng, Jinyong Peng, Yuan Lin, Pengyuan Sun. Sesamin Protects against and Ameliorates Rat Intestinal Ischemia/Reperfusion Injury with Involvement of Activating Nrf2/HO-1/NQO1 Signaling Pathway. Oxidative medicine and cellular longevity. 2021; 2021(?):5147069. doi: 10.1155/2021/5147069. [PMID: 34630849]
  • Ren-Ai Xu, Wei Sun, Ruimin Chen, Naihua Liu, Chengke Huang. Inhibitory effect of sesamin on ivabradine metabolism in rats. Pakistan journal of pharmaceutical sciences. 2020 Nov; 33(6):2543-2546. doi: NULL. [PMID: 33867328]
  • Erisa Harada, Jun Murata, Eiichiro Ono, Hiromi Toyonaga, Akira Shiraishi, Kosuke Hideshima, Masayuki P Yamamoto, Manabu Horikawa. (+)-Sesamin-oxidising CYP92B14 shapes specialised lignan metabolism in sesame. The Plant journal : for cell and molecular biology. 2020 11; 104(4):1117-1128. doi: 10.1111/tpj.14989. [PMID: 32955771]
  • Tianyang Wang, Song Lin, Hua Li, Ran Liu, Zihan Liu, Huarong Xu, Qing Li, Kaishun Bi. A stepwise integrated multi-system to screen quality markers of Chinese classic prescription Qingzao Jiufei decoction on the treatment of acute lung injury by combining 'network pharmacology-metabolomics-PK/PD modeling'. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Nov; 78(?):153313. doi: 10.1016/j.phymed.2020.153313. [PMID: 32866904]
  • Jinling Cao, Cuiping Feng, Lingtian Xie, Lijuan Li, Jianjie Chen, Shaojun Yun, Wenjing Guo, Tianyu Wang, Yijie Wu, Rui Meng, Guodong Wang, Xinjing He, Yongju Luo. Sesamin attenuates histological alterations, oxidative stress and expressions of immune-related genes in liver of zebrafish (Danio rerio) exposed to fluoride. Fish & shellfish immunology. 2020 Nov; 106(?):715-723. doi: 10.1016/j.fsi.2020.08.039. [PMID: 32860904]
  • Amin F Majdalawieh, Sarah Dalibalta, Sarah M Yousef. Effects of sesamin on fatty acid and cholesterol metabolism, macrophage cholesterol homeostasis and serum lipid profile: A comprehensive review. European journal of pharmacology. 2020 Oct; 885(?):173417. doi: 10.1016/j.ejphar.2020.173417. [PMID: 32750369]
  • Yutong Sui, Shiyou Li, Yahui Zhao, Qing Liu, Yanjiang Qiao, Li Feng, Sheng Li. Identification of a natural compound, sesamin, as a novel TRPM8 antagonist with inhibitory effects on prostate adenocarcinoma. Fitoterapia. 2020 Sep; 145(?):104631. doi: 10.1016/j.fitote.2020.104631. [PMID: 32439453]
  • Miharu Fujii, Kaori Yasuda, Toshiyuki Sakaki. Inhibitory effects of sesamin on CYP2C9-dependent 7-hydroxylation of S-warfarin. Drug metabolism and pharmacokinetics. 2020 Aug; 35(4):368-373. doi: 10.1016/j.dmpk.2020.05.002. [PMID: 32601017]
  • S Shimoyoshi, D Takemoto, Y Kishimoto, A Amano, A Sato, Y Ono, T Rogi, H Shibata, A Ishigami. Sesame lignans suppress age-related disorders of the kidney in mice. European review for medical and pharmacological sciences. 2020 05; 24(9):5140-5147. doi: 10.26355/eurrev_202005_21208. [PMID: 32432778]
  • Yazhen Chen, Hetong Lin, Mengshi Lin, Yongzhan Zheng, Jicheng Chen. Effect of roasting and in vitro digestion on phenolic profiles and antioxidant activity of water-soluble extracts from sesame. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 May; 139(?):111239. doi: 10.1016/j.fct.2020.111239. [PMID: 32145351]
  • Maurizio D'Auria, Marisabel Mecca, Luigi Todaro. High temperature treatment allows the detection of episesamin in paulownia wood extractives. Natural product research. 2020 May; 34(9):1326-1330. doi: 10.1080/14786419.2018.1560289. [PMID: 30663367]
  • Norifumi Tateishi, Satoshi Morita, Izumi Yamazaki, Hitoshi Okumura, Masaru Kominami, Sota Akazawa, Ayuta Funaki, Namino Tomimori, Tomohiro Rogi, Hiroshi Shibata, Shigenobu Shibata. Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism in rats. Chronobiology international. 2020 04; 37(4):493-509. doi: 10.1080/07420528.2019.1700998. [PMID: 31833423]
  • Lu Jin, Michael Schmiech, Menna El Gaafary, Xinlei Zhang, Tatiana Syrovets, Thomas Simmet. A comparative study on root and bark extracts of Eleutherococcus senticosus and their effects on human macrophages. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153181. doi: 10.1016/j.phymed.2020.153181. [PMID: 32065954]
  • Eiichiro Ono, Toshiyuki Waki, Daiki Oikawa, Jun Murata, Akira Shiraishi, Hiromi Toyonaga, Masako Kato, Naoki Ogata, Seiji Takahashi, Masa-Atsu Yamaguchi, Manabu Horikawa, Toru Nakayama. Glycoside-specific glycosyltransferases catalyze regio-selective sequential glucosylations for a sesame lignan, sesaminol triglucoside. The Plant journal : for cell and molecular biology. 2020 03; 101(5):1221-1233. doi: 10.1111/tpj.14586. [PMID: 31654577]
  • Weiran Dai, Yue Sun, Guoqiang Zhong. A Network Pharmacology Approach to Estimate the Active Ingredients and Potential Targets of Cuscutae semen in the Treatment of Osteoporosis. Medical science monitor : international medical journal of experimental and clinical research. 2020 Feb; 26(?):e920485. doi: 10.12659/msm.920485. [PMID: 32081843]
  • B H Ali, S Al Salam, Y Al Suleimani, M Al Za'abi, M Ashique, P Manoj, M Sudhadevi, M Al Tobi, A Nemmar. Ameliorative effect of sesamin in cisplatin-induced nephrotoxicity in rats by suppressing inflammation, oxidative/nitrosative stress, and cellular damage. Physiological research. 2020 02; 69(1):61-72. doi: 10.33549/physiolres.934142. [PMID: 31852200]
  • Yueming Chen, Huachao Li, Weinan Zhang, Wanchen Qi, Changpeng Lu, Huiliang Huang, Zhicheng Yang, Bing Liu, Luyong Zhang. Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway. Toxicology and applied pharmacology. 2020 01; 387(?):114848. doi: 10.1016/j.taap.2019.114848. [PMID: 31809756]
  • Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer. Bioorganic & medicinal chemistry. 2020 01; 28(1):115180. doi: 10.1016/j.bmc.2019.115180. [PMID: 31784199]
  • Qianxu Wang, Mengzhen Jia, Yihang Zhao, Yan Hui, Junru Pan, Hongfei Yu, Shikai Yan, Xiaoshuang Dai, Xuebo Liu, Zhigang Liu. Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure. Journal of agricultural and food chemistry. 2019 Nov; 67(45):12441-12451. doi: 10.1021/acs.jafc.9b03652. [PMID: 31674783]
  • Yi Zhang, Yue Ding, Tong Zhang, Xiaoyi Jiang, Yaxiong Yi, Lijuan Zhang, Yi Chen, Ting Li, Ping Kang, Juanjuan Tian. Quantitative Analysis of Twelve Active Components Combined With Chromatographic Fingerprint for Comprehensive Evaluation of Qinma Prescription by Ultra-Performance Liquid Chromatography Coupled With Diode Array Detection. Journal of chromatographic science. 2019 Oct; 57(9):855-865. doi: 10.1093/chromsci/bmz060. [PMID: 31560746]
  • Paola Cetera, Maurizio D'Auria, Marisabel Mecca, Luigi Todaro. Gallic acid as main product in the water extractives of Quercus frainetto ten. Natural product research. 2019 Oct; 33(19):2864-2867. doi: 10.1080/14786419.2018.1503266. [PMID: 30427753]
  • Bizhan Helli, Majid Mohammad Shahi, Karim Mowla, Mohammad Taha Jalali, Hossein Khadem Haghighian. A randomized, triple-blind, placebo-controlled clinical trial, evaluating the sesamin supplement effects on proteolytic enzymes, inflammatory markers, and clinical indices in women with rheumatoid arthritis. Phytotherapy research : PTR. 2019 Sep; 33(9):2421-2428. doi: 10.1002/ptr.6433. [PMID: 31309643]
  • Sepideh Ghotbzadeh Kermani, Ghodratollah Saeidi, Mohammad R Sabzalian, Alberto Gianinetti. Drought stress influenced sesamin and sesamolin content and polyphenolic components in sesame (Sesamum indicum L.) populations with contrasting seed coat colors. Food chemistry. 2019 Aug; 289(?):360-368. doi: 10.1016/j.foodchem.2019.03.004. [PMID: 30955624]
  • Masayuki Tera, Tomotsugu Koyama, Jun Murata, Ayako Furukawa, Shoko Mori, Toshiaki Azuma, Takehiro Watanabe, Katsuhito Hori, Atsushi Okazawa, Yasuaki Kabe, Makoto Suematsu, Honoo Satake, Eiichiro Ono, Manabu Horikawa. Identification of a binding protein for sesamin and characterization of its roles in plant growth. Scientific reports. 2019 06; 9(1):8631. doi: 10.1038/s41598-019-45003-7. [PMID: 31201340]
  • Kazuko Iwamoto, Shinichi Matsumura, Yuri Yoshioka, Ayami Yamamoto, Shohei Makino, Tatsuya Moriyama, Nobuhiro Zaima. Using Turmeric Oil as a Solvent Improves the Distribution of Sesamin-Sesamolin in the Serum and Brain of Mice. Lipids. 2019 05; 54(5):311-320. doi: 10.1002/lipd.12147. [PMID: 30993746]
  • Kaori Yasuda, Kairi Okamoto, Sera Ueno, Kasumi Itoh, Miyu Nishikawa, Shinichi Ikushiro, Toshiyuki Sakaki. Sulfate conjugates are the major metabolites in rats administrated with sesamin. Drug metabolism and pharmacokinetics. 2019 Apr; 34(2):134-140. doi: 10.1016/j.dmpk.2018.12.004. [PMID: 30770184]
  • Hirona Kugo, Chie Miyamoto, Ayaka Sawaragi, Kiyoto Hoshino, Yuka Hamatani, Shinichi Matsumura, Yuri Yoshioka, Tatsuya Moriyama, Nobuhiro Zaima. Sesame Extract Attenuates the Degradation of Collagen and Elastin Fibers in the Vascular Walls of Nicotine-administered Mice. Journal of oleo science. 2019; 68(1):79-85. doi: 10.5650/jos.ess18200. [PMID: 30606956]
  • Qing Fang, Yuyin Zhu, Qilai Wang, Meijun Song, Guosheng Gao, Zhiming Zhou. Suppression of cyclooxygenase 2 increases chemosensitivity to sesamin through the Akt‑PI3K signaling pathway in lung cancer cells. International journal of molecular medicine. 2019 Jan; 43(1):507-516. doi: 10.3892/ijmm.2018.3939. [PMID: 30365050]
  • Jinjie Liu, Chong Xu, Honglei Zhang, Fawang Liu, Dongming Ma, Zhong Liu. Comparative Transcriptomics Analysis for Gene Mining and Identification of a Cinnamyl Alcohol Dehydrogenase Involved in Methyleugenol Biosynthesis from Asarum sieboldii Miq. Molecules (Basel, Switzerland). 2018 Dec; 23(12):. doi: 10.3390/molecules23123184. [PMID: 30513938]
  • Ali-Mohammad Rousta, Seyed-Mohamad-Sadegh Mirahmadi, Alireza Shahmohammadi, Davood Nourabadi, Mohammad-Reza Khajevand-Khazaei, Tourandokht Baluchnejadmojarad, Mehrdad Roghani. Protective effect of sesamin in lipopolysaccharide-induced mouse model of acute kidney injury via attenuation of oxidative stress, inflammation, and apoptosis. Immunopharmacology and immunotoxicology. 2018 Oct; 40(5):423-429. doi: 10.1080/08923973.2018.1523926. [PMID: 30488751]
  • Marisabel Mecca, Luigi Todaro, Maurizio D'Auria. The Use of a Molybdenum Polyoxometalated Compound to Increase the Amount of Extractives from Wood Wastes. Biomolecules. 2018 07; 8(3):. doi: 10.3390/biom8030062. [PMID: 30060543]
  • Miran Jeong, Hye Mi Kim, Jin Su Lee, Jung-Hye Choi, Dae Sik Jang. (-)-Asarinin from the Roots of Asarum sieboldii Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells. Molecules (Basel, Switzerland). 2018 Jul; 23(8):. doi: 10.3390/molecules23081849. [PMID: 30044423]
  • Ayano Imai, Yuriko Oda, Naoki Ito, Shinobu Seki, Kiyotaka Nakagawa, Teruo Miyazawa, Fumitaka Ueda. Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study. Nutrients. 2018 Feb; 10(3):. doi: 10.3390/nu10030281. [PMID: 29495607]
  • Toshiyuki Sakaki, Kaori Yasuda, Miyu Nishikawa, Shinichi Ikushiro. [Metabolism of Sesamin and Drug-Sesamin Interaction]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2018; 138(3):357-363. doi: 10.1248/yakushi.17-00191-4. [PMID: 29503429]
  • Saleh Abu-Lafi, Sadam Makhamra, Ibrahim Rayan, Waseim Barriah, Ahmed Nasser, Basheer Abu Farkh, Anwar Rayan. Sesamin from Cuscuta palaestina natural plant extracts: Directions for new prospective applications. PloS one. 2018; 13(4):e0195707. doi: 10.1371/journal.pone.0195707. [PMID: 29634770]
  • Jun Murata, Eiichiro Ono, Seigo Yoroizuka, Hiromi Toyonaga, Akira Shiraishi, Shoko Mori, Masayuki Tera, Toshiaki Azuma, Atsushi J Nagano, Masaru Nakayasu, Masaharu Mizutani, Tatsuya Wakasugi, Masayuki P Yamamoto, Manabu Horikawa. Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame. Nature communications. 2017 12; 8(1):2155. doi: 10.1038/s41467-017-02053-7. [PMID: 29255253]
  • Namino Tomimori, Tomohiro Rogi, Hiroshi Shibata. Absorption, distribution, metabolism, and excretion of [14 C]sesamin in rats. Molecular nutrition & food research. 2017 08; 61(8):. doi: 10.1002/mnfr.201600844. [PMID: 27991716]
  • Di Fan, Zheng Yang, Yuan Yuan, Qing-Qing Wu, Man Xu, Ya-Ge Jin, Qi-Zhu Tang. Sesamin prevents apoptosis and inflammation after experimental myocardial infarction by JNK and NF-κB pathways. Food & function. 2017 Aug; 8(8):2875-2885. doi: 10.1039/c7fo00204a. [PMID: 28726929]
  • Soon-Il Kim, Young-Joon Ahn. Larvicidal activity of lignans and alkaloid identified in Zanthoxylum piperitum bark toward insecticide-susceptible and wild Culex pipiens pallens and Aedes aegypti. Parasites & vectors. 2017 May; 10(1):221. doi: 10.1186/s13071-017-2154-0. [PMID: 28472971]
  • Puttaraju Srikantamurthy Yashaswini, Bettadahalli Sadashivaiah, Talahalli Ravichandra Ramaprasad, Sridevi Annapurna Singh. In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans. The Journal of nutritional biochemistry. 2017 03; 41(?):151-157. doi: 10.1016/j.jnutbio.2016.12.010. [PMID: 28095362]
  • Takashi Ide, Haruka Iwase, Saaya Amano, Saki Sunahara, Ayuka Tachihara, Minako Yagi, Tsuyoshi Watanabe. Physiological effects of γ-linolenic acid and sesamin on hepatic fatty acid synthesis and oxidation. The Journal of nutritional biochemistry. 2017 03; 41(?):42-55. doi: 10.1016/j.jnutbio.2016.12.001. [PMID: 28040580]
  • Vinod Bhatt, Sushila Sharma, Neeraj Kumar, Upendra Sharma, Bikram Singh. Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF-MS/MS. Journal of pharmaceutical and biomedical analysis. 2017 Jan; 132(?):46-55. doi: 10.1016/j.jpba.2016.09.035. [PMID: 27693952]
  • Yun Zhu, Kayoko Kawaguchi, Ryoiti Kiyama. Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. PloS one. 2017; 12(2):e0171390. doi: 10.1371/journal.pone.0171390. [PMID: 28152041]
  • Ruijuan Zhang, Yan Yu, Senke Hu, Jinghua Zhang, Haixia Yang, Bei Han, Yue Cheng, Xiaoqin Luo. Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα. Nutrition research (New York, N.Y.). 2016 09; 36(9):1022-1030. doi: 10.1016/j.nutres.2016.06.015. [PMID: 27632923]
  • Meng-qiu Zhao, Peng-cheng Tu, You-nan Ren, Shan-jun Tao, Shu-guo Zheng. [Sesamin Preconditioning Attenuates Myocardial Ischemia Reperfusion Injury in Rats Through Activation of Akt/eNOS Signaling Pathway]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Jul; 39(7):1633-7. doi: . [PMID: 30204367]
  • Ruijuan Zhang, Yan Yu, Jianjun Deng, Chao Zhang, Jinghua Zhang, Yue Cheng, Xiaoqin Luo, Bei Han, Haixia Yang. Sesamin Ameliorates High-Fat Diet-Induced Dyslipidemia and Kidney Injury by Reducing Oxidative Stress. Nutrients. 2016 May; 8(5):. doi: 10.3390/nu8050276. [PMID: 27171111]
  • B Helli, K Mowla, M Mohammadshahi, M T Jalali. Effect of Sesamin Supplementation on Cardiovascular Risk Factors in Women with Rheumatoid Arthritis. Journal of the American College of Nutrition. 2016 May; 35(4):300-7. doi: 10.1080/07315724.2015.1005198. [PMID: 26151734]
  • Je-Seung Jeon, Chae Lee Park, Ahmed Shah Syed, Young-Mi Kim, Il Je Cho, Chul Young Kim. Preparative separation of sesamin and sesamolin from defatted sesame meal via centrifugal partition chromatography with consecutive sample injection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Feb; 1011(?):108-13. doi: 10.1016/j.jchromb.2015.12.062. [PMID: 26773888]
  • Daniel Załuski, Ewaryst Mendyk, Helena D Smolarz. Identification of MMP-1 and MMP-9 inhibitors from the roots of Eleutherococcus divaricatus, and the PAMPA test. Natural product research. 2016; 30(5):595-9. doi: 10.1080/14786419.2015.1027891. [PMID: 25835099]
  • Kanda Fanhchaksai, Kanchanok Kodchakorn, Peraphan Pothacharoen, Prachya Kongtawelert. Effect of sesamin against cytokine production from influenza type A H1N1-induced peripheral blood mononuclear cells: computational and experimental studies. In vitro cellular & developmental biology. Animal. 2016 Jan; 52(1):107-19. doi: 10.1007/s11626-015-9950-7. [PMID: 26424131]
  • Ting Li, Kelsey Ferns, Zi-Qiao Yan, Si-Yuan Yin, Jun-Jie Kou, Dongsheng Li, Zheng Zeng, Lin Yin, Xiaoyu Wang, Hong-Xia Bao, Yu-Jie Zhou, Qing-Hai Li, Zhan-Yi Zhao, Huidi Liu, Shu-Lin Liu. Acanthopanax senticosus: Photochemistry and Anticancer Potential. The American journal of Chinese medicine. 2016; 44(8):1543-1558. doi: 10.1142/s0192415x16500865. [PMID: 27852123]
  • Shingo Takada, Shintaro Kinugawa, Shouji Matsushima, Daisuke Takemoto, Takaaki Furihata, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Yoshiko Ono, Hiroshi Shibata, Koichi Okita, Hiroyuki Tsutsui. Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes. Experimental physiology. 2015 Nov; 100(11):1319-30. doi: 10.1113/ep085251. [PMID: 26300535]
  • Harvey A Schwertner, John J Stankus. Characterization of the Fluorescent Spectra and Intensities of Various Lignans: Application to HPLC Analysis with Fluorescent Detection†. Journal of chromatographic science. 2015 Oct; 53(9):1481-4. doi: 10.1093/chromsci/bmv041. [PMID: 25896657]
  • Jinling Cao, Jianjie Chen, Lingtian Xie, Jundong Wang, Cuiping Feng, Jing Song. Protective properties of sesamin against fluoride-induced oxidative stress and apoptosis in kidney of carp (Cyprinus carpio) via JNK signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). 2015 Oct; 167(?):180-90. doi: 10.1016/j.aquatox.2015.08.004. [PMID: 26340122]
  • Xiang Kong, Wei Li, Li-qun Guo, Jun-xiu Zhang, Xiang-pan Chen, Wei-yong Liu, Jie-ren Yang. Sesamin enhances nitric oxide bioactivity in aortas of spontaneously hypertensive rats. Therapeutic advances in cardiovascular disease. 2015 Oct; 9(5):314-24. doi: 10.1177/1753944715586178. [PMID: 26037786]
  • N Pathak, A Bhaduri, K V Bhat, A K Rai. Tracking sesamin synthase gene expression through seed maturity in wild and cultivated sesame species--a domestication footprint. Plant biology (Stuttgart, Germany). 2015 Sep; 17(5):1039-46. doi: 10.1111/plb.12327. [PMID: 25754459]
  • Yuan-qing Wang, Xing-ming Jiang, Zhi Wang, Wei Wang, Duan-fang Liao, Jian-ye Yan. [Analytical Methods with Qualitative HPLC Fingerprint and Quantitative Measurement of Effective Components of Processed Asari Radix et Rhizoma]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Jul; 38(7):1388-92. doi: . [PMID: 26946834]
  • Divya Pulivarthi, Kelly Marie Steinberg, Lianet Monzote, Abel Piñón, William N Setzer. Antileishmanial Activity of Compounds Isolated from Sassafras albidum. Natural product communications. 2015 Jul; 10(7):1229-30. doi: . [PMID: 26411017]
  • Satoshi Yamauchi, Hiroaki Ichikawa, Hisashi Nishiwaki, Yoshihiro Shuto. Evaluation of plant growth regulatory activity of furofuran lignan bearing a 7,9':7',9-diepoxy structure using optically pure (+)- and (-)-enantiomers. Journal of agricultural and food chemistry. 2015 Jun; 63(21):5224-8. doi: 10.1021/acs.jafc.5b01099. [PMID: 25955149]
  • Peiyuan Xu, Fei Cai, Xiaofei Liu, Lele Guo. Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells. Oncology reports. 2015 Jun; 33(6):3117-23. doi: 10.3892/or.2015.3888. [PMID: 25845399]
  • Li Ma, Xia Gong, Ge Kuang, Rong Jiang, Rongchun Chen, Jingyuan Wan. Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice. Biochemical and biophysical research communications. 2015 May; 461(2):230-6. doi: 10.1016/j.bbrc.2015.03.154. [PMID: 25866179]
  • Shu-guo Zheng, You-nan Ren, Meng-qiu Zhao, Shan-jun Tao, Xiang Kong, Jie-ren Yang. [Effect of Serum Containing Sesamin on Angiotensin II-Induced Apoptosis in Rat Cardiomyocytes]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 May; 38(5):1013-7. doi: . [PMID: 26767298]
  • Chien-Wei Hou, Shun-Yu Chang, Kee-Ching Jeng. Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on Aβ-stressed PC12 cells. Archives of pharmacal research. 2015 Apr; 38(4):543-8. doi: 10.1007/s12272-014-0426-1. [PMID: 25074037]
  • Yin Tong Liang, Jingnan Chen, Rui Jiao, Cheng Peng, Yuanyuan Zuo, Lin Lei, Yuwei Liu, Xiaobo Wang, Ka Ying Ma, Yu Huang, Zhen-Yu Chen. Cholesterol-lowering activity of sesamin is associated with down-regulation on genes of sterol transporters involved in cholesterol absorption. Journal of agricultural and food chemistry. 2015 Mar; 63(11):2963-9. doi: 10.1021/jf5063606. [PMID: 25745846]
  • Shuguo Zheng, Mengqiu Zhao, Younan Ren, Yuanjie Wu, Jieren Yang. Sesamin suppresses STZ induced INS-1 cell apoptosis through inhibition of NF-κB activation and regulation of Bcl-2 family protein expression. European journal of pharmacology. 2015 Mar; 750(?):52-8. doi: 10.1016/j.ejphar.2015.01.031. [PMID: 25637086]
  • Takumi Tomono, Kyoma Otsuka, Kentaro Yano, Masahiko Kanagawa, Hiroshi Arakawa, Takuo Ogihara. Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats. Biological & pharmaceutical bulletin. 2015; 38(12):1960-3. doi: 10.1248/bpb.b15-00392. [PMID: 26632187]
  • Dan Lv, Chang-Qing Zhu, Li Liu. Sesamin ameliorates oxidative liver injury induced by carbon tetrachloride in rat. International journal of clinical and experimental pathology. 2015; 8(5):5733-8. doi: . [PMID: 26191289]
  • Xiaowei Chen, Xiaozhou Ying, Lu Chen, Weiwei Zhang, Youcai Zhang. Protective effects of sesamin on liver fibrosis through antioxidative and anti-inflammatory activities in rats. Immunopharmacology and immunotoxicology. 2015; 37(5):465-72. doi: 10.3109/08923973.2015.1085064. [PMID: 26466645]
  • Takashi Ide, Ayana Azechi, Sayaka Kitade, Yoko Kunimatsu, Natsuko Suzuki, Chihiro Nakajima, Naoki Ogata. Comparative effects of sesame seeds differing in lignan contents and composition on fatty acid oxidation in rat liver. Journal of oleo science. 2015; 64(2):211-22. doi: 10.5650/jos.ess14182. [PMID: 25748381]
  • Vladimir Zlabek, AnnaLotta Schiller Vestergren, Sofia Trattner, Liane Wagner, Jana Pickova, Galia Zamaratskaia. Stimulatory effect of sesamin on hepatic cytochrome P450 activities in Atlantic salmon (Salmo salar L.) is not directly associated with expression of genes related to xenobiotic metabolism. Xenobiotica; the fate of foreign compounds in biological systems. 2015; 45(7):598-604. doi: 10.3109/00498254.2015.1007111. [PMID: 25673088]
  • Saif Ahmad, Nehal M Elsherbiny, Rizwanul Haque, M Badruzzaman Khan, Tauheed Ishrat, Zahoor A Shah, Mohammad M Khan, Mehboob Ali, Arshad Jamal, Deepshikha Pande Katare, Gregory I Liou, Kanchan Bhatia. Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke. Neurotoxicology. 2014 Dec; 45(?):100-10. doi: 10.1016/j.neuro.2014.10.002. [PMID: 25316624]
  • Kuo-Ching Jan, Binghuei-Barry Yang, Tristan C Liu. Gene expression profiling of sesaminol triglucoside and its tetrahydrofuranoid metabolites in primary rat hepatocytes. International journal of food sciences and nutrition. 2014 Dec; 65(8):981-8. doi: 10.3109/09637486.2014.950204. [PMID: 25156454]
  • Takeshi Yokoyama, Yuto Kosaka, Mineyuki Mizuguchi. Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin. Journal of medicinal chemistry. 2014 Nov; 57(21):8928-35. doi: 10.1021/jm500997m. [PMID: 25314129]
  • Mizuki Fukunaga, Masatoshi Ohnishi, Ayano Shiratsuchi, Takuya Kawakami, Madoka Takahashi, Misato Motomura, Kyohei Egusa, Tomoka Urasaki, Atsuko Inoue. Sesamin increases heme oxygenase-1 protein in RAW 264.7 macrophages through inhibiting its ubiquitination process. European journal of pharmacology. 2014 Oct; 741(?):214-21. doi: 10.1016/j.ejphar.2014.08.015. [PMID: 25169430]