Astilbin (BioDeep_00000000950)

Main id: BioDeep_00000269965

Secondary id: BioDeep_00000269793

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3-dihydrochromen-4-one

化学式: C21H22O11 (450.11620619999997)
中文名称: 新异落新妇苷, 异落新妇苷, 新落新妇苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O
InChI: InChI=1S/C21H22O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-26,28-29H,1H3

描述信息

Neoastilbin is a flavanone glycoside that is (-)-taxifolin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage. It is an alpha-L-rhamnoside, a member of 3-hydroxyflavanones, a tetrahydroxyflavanone, a monosaccharide derivative, a flavanone glycoside and a member of 4-hydroxyflavanones. It is functionally related to a (-)-taxifolin. It is an enantiomer of an astilbin.
Neoastilbin is a natural product found in Neolitsea sericea, Dimorphandra mollis, and other organisms with data available.
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research[1][21][3].
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research[1][21][3].
Neoisoastilbin possesses antioxidant, anti-hyperuricemic and anti-Inflammatory activities[1].
Neoisoastilbin possesses antioxidant, anti-hyperuricemic and anti-Inflammatory activities[1].
Neosmitilbin is?isolated from?Garcinia?mangostana.
Neosmitilbin is?isolated from?Garcinia?mangostana.

同义名列表

8 个代谢物同义名

(2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3-dihydrochromen-4-one; (2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside; (2S,3S)-dihydroquercetin 3-O-alpha-L-rhamnoside; (2S,3S)-Taxifolin 3-rhamnoside; neoisoastilbin; Neosmitilbin; isoastilbin; Neoastilbin



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wenyuan Xu, You Dai. Lipid Carrier Nanostructured Astilbin Ameliorates Rotenone-Induced Neurodegeneration in Mice Brain via Modulation of GSK3β-Nrf2 Signaling Pathways. Journal of oleo science. 2024; 73(3):371-387. doi: 10.5650/jos.ess23173. [PMID: 38433001]
  • Hongjuan Xia, Chenghao Lv, Yuting Lu, Chaoxi Zeng, Si Qin, Meng Shi. Natural deep eutectic ready to use extract of astilbin: Super high in vitro bioaccessibility, α-amylase and α-glucosidase enzyme inhibition kinetics. Food research international (Ottawa, Ont.). 2023 11; 173(Pt 2):113368. doi: 10.1016/j.foodres.2023.113368. [PMID: 37803707]
  • Lijuan Liu, Yayun Wu, Ya Zhao, Chuanjian Lu, Ruizhi Zhao. Citric Acid Enhances the Activities of Astilbin on Psoriasis via Down-Regulation of P-Glycoprotein. Molecular pharmaceutics. 2023 Mar; ?(?):. doi: 10.1021/acs.molpharmaceut.2c00889. [PMID: 36862757]
  • Komgrit Eawsakul, Tassanee Ongtanasup, Ngamrayu Ngamdokmai, Kingkan Bunluepuech. Alpha-glucosidase inhibitory activities of astilbin contained in Bauhinia strychnifolia Craib. stems: an investigation by in silico and in vitro studies. BMC complementary medicine and therapies. 2023 Jan; 23(1):25. doi: 10.1186/s12906-023-03857-5. [PMID: 36717857]
  • Yutong Ding, Lijuan Liu, Yayun Wu, Yang Wang, Ruizhi Zhao. Optimization of the Transdermal Delivery System in Astilbin Microemulsion with Improved Stability and Anti-psoriatic Activity. Current drug delivery. 2023; 20(3):281-291. doi: 10.2174/1567201819666220425092114. [PMID: 35469567]
  • Xiangyu Han, Jing Sun, Tianmei Niu, Beibei Mao, Shijie Gao, Pan Zhao, Linlin Sun. Molecular Insight into the Binding of Astilbin with Human Serum Albumin and Its Effect on Antioxidant Characteristics of Astilbin. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144487. [PMID: 35889360]
  • Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhang. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte. Fish & shellfish immunology. 2022 Jun; 125(?):230-237. doi: 10.1016/j.fsi.2022.05.021. [PMID: 35577320]
  • Tingwei Wang, Yongli Ye, Jian Ji, Shuang Zhang, Xingxing Yang, Jiayuan Xu, Jia-Sheng Wang, Zhiyuan Chen, Bangen Xia, Hongfang Shen, Ruowei Xia, Wenqin Shi, Xiulan Sun. Astilbin from Smilax glabra Roxb. alleviates high-fat diet-induced metabolic dysfunction. Food & function. 2022 May; 13(9):5023-5036. doi: 10.1039/d2fo00060a. [PMID: 35388843]
  • Qingqing Xu, Zhaoyang Liu, Zhiqiang Cao, Yongjian Shi, Ning Yang, Guangshang Cao, Chunmin Zhang, Rong Sun, Chunhong Zhang. Topical astilbin ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice via suppression dendritic cell-Th17 inflammation axis. Journal of cellular and molecular medicine. 2022 02; 26(4):1281-1292. doi: 10.1111/jcmm.17184. [PMID: 35023281]
  • Yi-Ting Ruan, Wen-Jun Wang, Guo-Dong Zheng, Zhong-Ping Yin, Ji-Guang Chen, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang. In vivo and in vitro comparison of three astilbin encapsulated zein nanoparticles with different outer shells. Food & function. 2021 Oct; 12(20):9784-9792. doi: 10.1039/d1fo01522b. [PMID: 34533153]
  • Yue Zhang, Chuanbo Ding, Yuan Cai, Xueyan Chen, Yingchun Zhao, Xinglong Liu, Jinping Zhang, Shunwen Sun, Wencong Liu. Astilbin ameliorates oxidative stress and apoptosis in D-galactose-induced senescence by regulating the PI3K/Akt/m-TOR signaling pathway in the brains of mice. International immunopharmacology. 2021 Oct; 99(?):108035. doi: 10.1016/j.intimp.2021.108035. [PMID: 34435579]
  • Licong Yang, Yanping Zhu, Shusheng Zhong, Guodong Zheng. Astilbin lowers the effective caffeine dose for decreasing lipid accumulation via activating AMPK in high-fat diet-induced obese mice. Journal of the science of food and agriculture. 2021 Jan; 101(2):573-581. doi: 10.1002/jsfa.10669. [PMID: 32673411]
  • Shan Jiang, Haoran Li, Ailin Yang, Hongbing Zhang, Pingping Dong, Fan Dong, Long Dai, Shaoping Wang, Jiayu Zhang. Comprehensive Identification of Astilbin Metabolites in Rats Based on Multiple Metabolite Templates Combined with UHPLC-Q-Exactive Mass Spectrometry. Current drug metabolism. 2021; 22(10):811-823. doi: 10.2174/1389200222666210811110619. [PMID: 34382519]
  • Shuaibo Sun, Zijian Yan, Xiaolong Shui, Weihui Qi, Yanlin Chen, Xinxian Xu, Yuezheng Hu, Weijun Guo, Ping Shang. Astilbin prevents osteoarthritis development through the TLR4/MD-2 pathway. Journal of cellular and molecular medicine. 2020 11; 24(22):13104-13114. doi: 10.1111/jcmm.15915. [PMID: 33063931]
  • Dan Zheng, Yi-Ting Ruan, Zhong-Ping Yin, Qing-Feng Zhang. A Comparison of Solubility, Stability, and Bioavailability between Astilbin and Neoastilbin Isolated from Smilax glabra Rhizoma. Molecules (Basel, Switzerland). 2020 Oct; 25(20):. doi: 10.3390/molecules25204728. [PMID: 33076319]
  • Yemin Xu, Keyan Wu, Sen Han, Shizhen Ding, Guotao Lu, Zhijie Lin, Yu Zhang, Weiming Xiao, Weijuan Gong, Yanbing Ding, Bin Deng. Astilbin combined with lipopolysaccharide induces IL-10-producing regulatory B cells via the STAT3 signalling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Sep; 129(?):110450. doi: 10.1016/j.biopha.2020.110450. [PMID: 32768945]
  • Meiyun Shi, Mengyao Xu, Lei Yin. Pharmacokinetic, bioavailability and tissue distribution study of astilbin in rats. The Journal of pharmacy and pharmacology. 2020 Aug; 72(8):1061-1071. doi: 10.1111/jphp.13282. [PMID: 32346882]
  • Sen Han, Zhijie Lin, Jianqiang Wen, Keyan Wu, Yemin Xu, Yu Zhang, Guotao Lu, Weiming Xiao, Yanbing Ding, Xiaoqin Jia, Bin Deng, Weijuan Gong. Astilbin promotes the induction of regulatory NK1.1- CD4+ NKG2D+ T cells through the PI3K, STAT3, and MAPK signaling pathways. International immunopharmacology. 2020 Apr; 81(?):106143. doi: 10.1016/j.intimp.2019.106143. [PMID: 32062080]
  • Haiming Jin, Qingqing Wang, Kai Chen, Ke Xu, Hao Pan, Feifan Chu, Zhen Ye, Ziyi Wang, Jennifer Tickner, Heng Qiu, Chao Wang, Jacob Kenny, Huazi Xu, Te Wang, Jiake Xu. Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis. Journal of cellular and molecular medicine. 2019 12; 23(12):8355-8368. doi: 10.1111/jcmm.14713. [PMID: 31603626]
  • So-Yeon Jeon, Na-Hyun Kim, Yu-Jeong Kim, Kyung-A Lee, Yukiori Goto, Young-A Lee. The effects of Engelhardtia chrysolepis Hance on long-term memory and potential dopamine involvement in mice. Behavioural pharmacology. 2019 10; 30(7):596-604. doi: 10.1097/fbp.0000000000000495. [PMID: 31503068]
  • Dan Zheng, Cui-Cui Sun, Hang Su, Qing-Feng Zhang. Metabolism, Excretion, and Tissue Distribution of Astilbin-Zein Nanoparticles in Rats. Journal of agricultural and food chemistry. 2019 Jul; 67(30):8332-8338. doi: 10.1021/acs.jafc.9b02569. [PMID: 31298538]
  • Liping Huang, Jiao Deng, Guangtong Chen, Meng Zhou, Jian Liang, Bo Yan, Jicheng Shu, Yonghong Liang, Huilian Huang. The anti-hyperuricemic effect of four astilbin stereoisomers in Smilax glabra on hyperuricemic mice. Journal of ethnopharmacology. 2019 Jun; 238(?):111777. doi: 10.1016/j.jep.2019.03.004. [PMID: 30851369]
  • Guoyan Liang, Yichu Nie, Yunbing Chang, Shixing Zeng, Changxiang Liang, Xiaoqing Zheng, Dan Xiao, Shiqiang Zhan, Qiujian Zheng. Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jun; 59(?):152772. doi: 10.1016/j.phymed.2018.11.032. [PMID: 31005813]
  • Hong Yu, Bo Yuan, Qiubo Chu, Chunyue Wang, Hui Bi. Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis. International journal of molecular medicine. 2019 Mar; 43(3):1406-1416. doi: 10.3892/ijmm.2019.4058. [PMID: 30664148]
  • Lucksagoon Ganranoo, Ratchanaporn Chokchaisiri, Kate Grudpan. Simple simultaneous determination of iron and manganese by sequential injection spectrophotometry using astilbin extracted from Smilax china L. root. Talanta. 2019 Jan; 191(?):307-312. doi: 10.1016/j.talanta.2018.08.076. [PMID: 30262065]
  • Xiaoqi Sun, Hong Zhang, Yingyu Zhang, Qi Yang, Shujie Zhao. Caspase-dependent mitochondrial apoptotic pathway is involved in astilbin-mediated cytotoxicity in breast carcinoma cells. Oncology reports. 2018 Oct; 40(4):2278-2286. doi: 10.3892/or.2018.6602. [PMID: 30066940]
  • Fang Chen, Zhiqiang Sun, Xiaoguang Zhu, Yali Ma. Astilbin inhibits high glucose-induced autophagy and apoptosis through the PI3K/Akt pathway in human proximal tubular epithelial cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Oct; 106(?):1175-1181. doi: 10.1016/j.biopha.2018.07.072. [PMID: 30119185]
  • Xiao-Han Wang, Rui-Na Zhong, Bao-de Shen, Cheng-Ying Shen, Xiao Liu, Bo Dai, Hai-Long Yuan. [Preparation of astilbin amorphous nanosuspension and its in vitro evaluation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Apr; 43(8):1626-1632. doi: 10.19540/j.cnki.cjcmm.20180117.003. [PMID: 29751709]
  • Si-Wei Wang, Yi Xu, Yuan-Yuan Weng, Xue-Yu Fan, Yong-Feng Bai, Xiao-Yan Zheng, Li-Jun Lou, Feng Zhang. Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Apr; 114(?):227-236. doi: 10.1016/j.fct.2018.02.041. [PMID: 29471006]
  • Jinghong Yu, Zhicai Xiao, Ruizhi Zhao, Chuanjian Lu, Yuemei Zhang. Astilbin emulsion improves guinea pig lesions in a psoriasis-like model by suppressing IL-6 and IL-22 via p38 MAPK. Molecular medicine reports. 2018 03; 17(3):3789-3796. doi: 10.3892/mmr.2017.8343. [PMID: 29286161]
  • Shiyao Hua, Yiwei Zhang, Jiayue Liu, Lin Dong, Jun Huang, Dingbo Lin, Xueyan Fu. Ethnomedicine, Phytochemistry and Pharmacology of Smilax glabra: An Important Traditional Chinese Medicine. The American journal of Chinese medicine. 2018; 46(2):261-297. doi: 10.1142/s0192415x18500143. [PMID: 29433390]
  • Géssica Alves Fraga, Sikiru Olaitan Balogun, Emilly Della Pascqua, Ruberlei Godinho de Oliveira, Guilherme Botelho, Eduarda Pavan, Thiago da Rosa Lima, Eudes Thiago Pereira Avila, Clarissa de Medeiros Amorim Krueger, Valdir Cechinel Filho, Amílcar Sabino Damazo, Domingos Tabajara de Oliveira Martins, Fabrício Azevedo Voltarelli. Heteropterys tomentosa A. Juss: Toxicological and adaptogenic effects in experimental models. Nutrition and health. 2017 Dec; 23(4):289-298. doi: 10.1177/0260106017729908. [PMID: 29214921]
  • Yonglin Gao, Chunmei Li, Yunzhi Wang, Yunguo Liu, Guisheng Li, Xiaochen Fan, Yanshen Li, Jingwei Tian, Albert W Lee. Nonclinical safety of astilbin: A 4-week oral toxicity study in rats with genotoxicity, chromosomal aberration, and mammalian micronucleus tests. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Sep; 107(Pt A):1-9. doi: 10.1016/j.fct.2017.06.024. [PMID: 28624472]
  • Cuiyan Liu, Youxi Kang, Xiuhong Zhou, Zisheng Yang, Jingang Gu, Chunyang Han. Rhizoma smilacis glabrae protects rats with gentamicin-induced kidney injury from oxidative stress-induced apoptosis by inhibiting caspase-3 activation. Journal of ethnopharmacology. 2017 Feb; 198(?):122-130. doi: 10.1016/j.jep.2016.12.034. [PMID: 28034658]
  • Nguyen Huy Thuan, Sailesh Malla, Nguyen Thanh Trung, Dipesh Dhakal, Anaya Raj Pokhrel, Luan Luong Chu, Jae Kyung Sohng. Microbial production of astilbin, a bioactive rhamnosylated flavanonol, from taxifolin. World journal of microbiology & biotechnology. 2017 Feb; 33(2):36. doi: 10.1007/s11274-017-2208-7. [PMID: 28120309]
  • Rodrigo Alonso, Federico J Berli, Ariel Fontana, Patricia Piccoli, Rubén Bottini. Malbec grape (Vitis vinifera L.) responses to the environment: Berry phenolics as influenced by solar UV-B, water deficit and sprayed abscisic acid. Plant physiology and biochemistry : PPB. 2016 Dec; 109(?):84-90. doi: 10.1016/j.plaphy.2016.09.007. [PMID: 27642694]
  • Ming Wang, Jing Zhao, Nan Zhang, Jianghua Chen. Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Oct; 83(?):975-988. doi: 10.1016/j.biopha.2016.07.025. [PMID: 27522260]
  • Qing-Fang Meng, Zheng Zhang, Yan-Jun Wang, Wei Chen, Fei-Fei Li, Long-Tao Yue, Chang-Jun Zhang, Heng Li, Min Zhang, Cong-Cong Wang, Peng Zhang, Hui Chen, Rui-Sheng Duan, Shan-Mei Sun, Yan-Bin Li. Astilbin ameliorates experimental autoimmune myasthenia gravis by decreased Th17 cytokines and up-regulated T regulatory cells. Journal of neuroimmunology. 2016 09; 298(?):138-45. doi: 10.1016/j.jneuroim.2016.07.016. [PMID: 27609287]
  • Ting-Ting Di, Zhi-Tong Ruan, Jing-Xia Zhao, Yan Wang, Xin Liu, Ying Wang, Ping Li. Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway. International immunopharmacology. 2016 Mar; 32(?):32-38. doi: 10.1016/j.intimp.2015.12.035. [PMID: 26784569]
  • Arunporn Itharat, Kamonmas Srikwan, Srisopa Ruangnoo, Pakakrong Thongdeeying. Anti-Allergic Activities of Smilax glabra Rhizome Extracts and Its Isolated Compounds. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2015 Apr; 98 Suppl 3(?):S66-74. doi: . [PMID: 26387391]
  • Haiming Shi, Man Liu, Rui Wang, Boyan Gao, Zhongfei Zhang, Yuge Niu, Liangli Lucy Yu. Separating four diastereomeric pairs of dihydroflavonol glycosides from Engelhardia roxburghiana using high performance counter-current chromatography. Journal of chromatography. A. 2015 Feb; 1383(?):79-87. doi: 10.1016/j.chroma.2015.01.024. [PMID: 25620740]
  • Lele Guo, Wen Liu, Tingting Lu, Wenjie Guo, Jian Gao, Qiong Luo, Xuefeng Wu, Yang Sun, Xudong Wu, Yan Shen, Qiang Xu. Decrease of Functional Activated T and B Cells and Treatment of Glomerulonephitis in Lupus-Prone Mice Using a Natural Flavonoid Astilbin. PloS one. 2015; 10(4):e0124002. doi: 10.1371/journal.pone.0124002. [PMID: 25867237]
  • Min Zhao, Jun Xu, Dawei Qian, Jianming Guo, Shu Jiang, Er-xin Shang, Jin-ao Duan. Identification of astilbin metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. Biomedical chromatography : BMC. 2014 Jul; 28(7):1024-9. doi: 10.1002/bmc.3111. [PMID: 24399635]
  • Yan He, Hongfei Liu, Zhiyong Xie, Qiongfeng Liao, Xiaoping Lai, Zhiyun Du. PVP and surfactant combined carrier as an effective absorption enhancer of poorly soluble astilbin in vitro and in vivo. Drug development and industrial pharmacy. 2014 Feb; 40(2):237-43. doi: 10.3109/03639045.2012.756008. [PMID: 23350723]
  • Huiling Diao, ZeChun Kang, Fang Han, Wanglin Jiang. Astilbin protects diabetic rat heart against ischemia-reperfusion injury via blockade of HMGB1-dependent NF-κB signaling pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Jan; 63(?):104-10. doi: 10.1016/j.fct.2013.10.045. [PMID: 24211745]
  • Jiayu Tang, Jianming Guo, Jingjing Fan, Cheng Qian, Feifei Tao, Xiang Zhou, Xuefeng Wu, Yang Sun, Jianxin Li, Yan Shen, Qiang Xu. Metabolite profiling of astilbin in rat sera using UPLC/MS(E) and impact of its metabolites on immunosuppressive activity. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Jun; 929(?):56-62. doi: 10.1016/j.jchromb.2013.04.018. [PMID: 23665891]
  • Zhao-Guang Zheng, Ting-Ting Duan, Bao He, Dan Tang, Xiao-Bin Jia, Ru-Shang Wang, Jia-Xiao Zhu, You-Hua Xu, Quan Zhu, Liang Feng. Macrophage biospecific extraction and HPLC-ESI-MSn analysis for screening immunological active components in Smilacis Glabrae Rhizoma. Journal of pharmaceutical and biomedical analysis. 2013 Apr; 77(?):44-8. doi: 10.1016/j.jpba.2013.01.003. [PMID: 23384550]
  • Rui-zhi Zhao, Ying Zhao, Li-qing Zhang, Chuan-jian Lu. Determination of isofraxidin and astilbin by HPLC in rat plasma and its application after orally administration the extract of Sarcandra glabra. Pakistan journal of pharmaceutical sciences. 2013 Jan; 26(1):1-6. doi: . [PMID: 23261720]
  • Qing-Feng Zhang, Hon-Yeung Cheung, Ling-Bin Zeng. Development of HPLC fingerprint for species differentiation and quality assessment of Rhizoma Smilacis Glabrae. Journal of natural medicines. 2013 Jan; 67(1):207-11. doi: 10.1007/s11418-012-0648-9. [PMID: 22382863]
  • Xi-Cheng He, Qin-Wen Shun, Li-Sha Dong, Xiang-Qian Ge, Hua Zhang, Heng Nong, Xiao-Hua Shen. [Comparison of anti-inflammatory effect and analysis of astilbin red and white transverse section Smilax glabra in 28 collection sites]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Dec; 37(23):3595-8. doi: 10.4268/cjcmm20122319. [PMID: 23477147]
  • Yinjie Wang, Ruizhi Zhao, Chuanjian Lu. [Comparative pharmacokinetics study of astilbin after oral administration of Yinxieling prescription or Smilacis Glabrae Rhizoma to rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jun; 37(12):1859-61. doi: 10.4268/cjcmm20121235. [PMID: 22997840]
  • Xiao-Ya Shang, Shuai Li, Su-Juan Wang, Yong-Chun Yang, Jian-Gong Shi. Chemical constituents of Bauhinia aurea. Journal of Asian natural products research. 2012; 14(10):966-72. doi: 10.1080/10286020.2012.728209. [PMID: 23046468]
  • Lvyi Chen, Zhou Lan, Yongqiang Zhou, Fei Li, Xin Zhang, Chunfeng Zhang, Zhonglin Yang, Ping Li. Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats. Planta medica. 2011 Nov; 77(16):1769-73. doi: 10.1055/s-0030-1271135. [PMID: 21614752]
  • Mai Fujiwara, Nobuo Yagi, Mitsuo Miyazawa. Tyrosinase inhibitory constituents from the bark of Peltophorum dasyrachis (yellow batai). Natural product research. 2011 Sep; 25(16):1540-8. doi: 10.1080/14786410903313106. [PMID: 21391111]
  • Jingqun Huang, Siwang Wang, Miaozhang Zhu, Jianzong Chen, Xiaoxing Zhu. Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Sep; 49(9):1943-7. doi: 10.1016/j.fct.2011.04.029. [PMID: 21600261]
  • Yong-Jiang Xu, Rica Capistrano, Liene Dhooghe, Kenn Foubert, Filip Lemière, Sheila Maregesi, Aliou Baldé, Sandra Apers, Luc Pieters. Herbal medicines and infectious diseases: characterization by LC-SPE-NMR of some medicinal plant extracts used against malaria. Planta medica. 2011 Jul; 77(11):1139-48. doi: 10.1055/s-0030-1270719. [PMID: 21328178]
  • Haiqiu Huang, Zhihong Cheng, Haiming Shi, Wenbo Xin, Thomas T Y Wang, Liangli Lucy Yu. Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana and their potential anti-inflammatory properties. Journal of agricultural and food chemistry. 2011 May; 59(9):4562-9. doi: 10.1021/jf2002969. [PMID: 21476602]
  • M D Lucas-Filho, G C Silva, S F Cortes, T R Mares-Guia, V Perpétua Ferraz, C P Serra, F C Braga. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Apr; 17(5):383-7. doi: 10.1016/j.phymed.2009.09.008. [PMID: 19879122]
  • Chao Wang, Liping Zhu, Jingzhi Yang, Chuangjun Li, Dongming Zhang. [Chemical constituents from Sarcandra glabra]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Mar; 35(6):714-7. doi: 10.4268/cjcmm20100612. [PMID: 20545194]
  • Fernando Petacci, Silvia S Freitas, Iguatemy L Brunetti, Najeh M Khalil. Inhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae). Biological research. 2010; 43(1):63-74. doi: /s0716-97602010000100008. [PMID: 21157633]
  • Gui-Sheng Li, Wang-Lin Jiang, Xi-Dian Yue, Gui-Wu Qu, Jing-Wei Tian, Juan Wu, Feng-Hua Fu. Effect of astilbin on experimental diabetic nephropathy in vivo and in vitro. Planta medica. 2009 Nov; 75(14):1470-5. doi: 10.1055/s-0029-1185802. [PMID: 19644810]
  • Shao-Hua Song, Xiao-Yun Shen, Fang Liu, Yi Tang, Zhen-Meng Wang, Zhi-Ren Fu. [Protective effects of astilbin on renal ischemia-reperfusion injury in rats]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2009 Aug; 7(8):753-7. doi: 10.3736/jcim20090809. [PMID: 19671414]
  • Yan Liang, Qiang Xu, An Kang, Yuan Xie, Tong Xie, Li Liu, Haiping Hao, Lin Xie, Guang-Ji Wang. Validation and application of an LC-ESI-MS method for simultaneous determination of astilbin and its major metabolite 3'-O-methylastilbin in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jun; 877(18-19):1765-70. doi: 10.1016/j.jchromb.2009.04.040. [PMID: 19451038]
  • Xiang Zhou, Qiang Xu, Jian-Xin Li, Ting Chen. Structural revision of two flavanonol glycosides from Smilax glabra. Planta medica. 2009 May; 75(6):654-5. doi: 10.1055/s-0029-1185360. [PMID: 19199231]
  • Xu-hong Yang, Huai-biao Li, Hong Chen, Ping Li, Bo-ping Ye. [Chemical constituents in the leave of Rhizophora stylosa L and their biological activities]. Yao xue xue bao = Acta pharmaceutica Sinica. 2008 Sep; 43(9):974-8. doi: ". [PMID: 19048793]
  • Fei Sa, Jian-Li Gao, Kwok-Pui Fung, Ying Zheng, Simon Ming-Yuen Lee, Yi-Tao Wang. Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines. Chemico-biological interactions. 2008 Jan; 171(1):1-14. doi: 10.1016/j.cbi.2007.08.012. [PMID: 17996228]
  • L Wirasathien, T Pengsuparp, R Suttisri, H Ueda, M Moriyasu, K Kawanishi. Inhibitors of aldose reductase and advanced glycation end-products formation from the leaves of Stelechocarpus cauliflorus R.E. Fr. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2007 Aug; 14(7-8):546-50. doi: 10.1016/j.phymed.2006.09.001. [PMID: 17084603]
  • Xiao-Ya Shang, Shuai Li, Su-Juan Wang, Yong-Chun Yang, Jian-Gong Shi. [Dihydroflavonol glycosides and flavan-3-ols from Bauhinia aurea]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 May; 32(9):815-8. doi: . [PMID: 17639982]
  • Liang Chen, Ye Yin, Hongwei Yi, Qiang Xu, Ting Chen. Simultaneous quantification of five major bioactive flavonoids in Rhizoma smilacis glabrae by high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis. 2007 Apr; 43(5):1715-20. doi: 10.1016/j.jpba.2007.01.007. [PMID: 17291706]
  • B Moulari, Y Pellequer, J P Chaumont, Y C Guillaume, J Millet. In vitro antimicrobial activity of the leaf extract of Harungana madagascariensis Lam. Ex Poir. (Hypericaceae) against strains causing otitis externa in dogs and cats. Acta veterinaria Hungarica. 2007 Mar; 55(1):97-105. doi: 10.1556/avet.55.2007.1.10. [PMID: 17385560]
  • Jianming Guo, Feng Qian, Jianxin Li, Qiang Xu, Ting Chen. Identification of a new metabolite of astilbin, 3'-O-methylastilbin, and its immunosuppressive activity against contact dermatitis. Clinical chemistry. 2007 Mar; 53(3):465-71. doi: 10.1373/clinchem.2006.077297. [PMID: 17272490]
  • Yoshiyuki Kimura, Maho Sumiyoshi, Masahiro Sakanaka. Effects of Astilbe thunbergii rhizomes on wound healing Part 1. Isolation of promotional effectors from Astilbe thunbergii rhizomes on burn wound healing. Journal of ethnopharmacology. 2007 Jan; 109(1):72-7. doi: 10.1016/j.jep.2006.07.007. [PMID: 16920297]
  • B Moulari, Y Pellequer, H Lboutounne, C Girard, J-P Chaumont, J Millet, F Muyard. Isolation and in vitro antibacterial activity of astilbin, the bioactive flavanone from the leaves of Harungana madagascariensis Lam. ex Poir. (Hypericaceae). Journal of ethnopharmacology. 2006 Jun; 106(2):272-8. doi: 10.1016/j.jep.2006.01.008. [PMID: 16483735]
  • Phan Van Kiem, Chau Van Minh, Hoang Thanh Huong, Jung Joon Lee, Im Seon Lee, Young Ho Kim. Phenolic constituents with inhibitory activity against NFAT transcription from Desmos chinensis. Archives of pharmacal research. 2005 Dec; 28(12):1345-9. doi: 10.1007/bf02977900. [PMID: 16392667]
  • Qizhen Du, Lei Li, Gerold Jerz. Purification of astilbin and isoastilbin in the extract of smilax glabra rhizome by high-speed counter-current chromatography. Journal of chromatography. A. 2005 Jun; 1077(1):98-101. doi: 10.1016/j.chroma.2005.04.072. [PMID: 15988992]
  • Jiu-zhi Yuan, De-qiang Dou, Ying-jie Chen, Wei Li, Koike Kazuo, Nikaido Tamotsu, Xin-sheng Yao. [Studies on dihydroflavonol glycosides from rhizome of Smilax glabra]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2004 Sep; 29(9):867-70. doi: . [PMID: 15575206]
  • Jianming Guo, Qiang Xu, Ting Chen. Quantitative determination of astilbin in rabbit plasma by liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Jun; 805(2):357-60. doi: 10.1016/j.jchromb.2004.03.014. [PMID: 15135113]
  • Jun Wang, Ying Zhao, Qiang Xu. Astilbin prevents concanavalin A-induced liver injury by reducing TNF-alpha production and T lymphocytes adhesion. The Journal of pharmacy and pharmacology. 2004 Apr; 56(4):495-502. doi: 10.1211/0022357023033. [PMID: 15104095]
  • Yu Cai, Ting Chen, Qiang Xu. Astilbin suppresses delayed-type hypersensitivity by inhibiting lymphocyte migration. The Journal of pharmacy and pharmacology. 2003 May; 55(5):691-6. doi: 10.1211/002235703765344612. [PMID: 12831513]
  • Luciane G Batista Pereira, Fernando Petacci, João B Fernandes, Arlene G Corrêa, Paulo C Vieira, M Fátima G F da Silva, Osmar Malaspina. Biological activity of astilbin from Dimorphandra mollis against Anticarsia gemmatalis and Spodoptera frugiperda. Pest management science. 2002 May; 58(5):503-7. doi: 10.1002/ps.478. [PMID: 11997979]
  • T H Chen, J C Liu, J J Chang, M F Tsai, M H Hsieh, P Chan. The in vitro inhibitory effect of flavonoid astilbin on 3-hydroxy-3-methylglutaryl coenzyme A reductase on Vero cells. Zhonghua yi xue za zhi = Chinese medical journal; Free China ed. 2001 Jul; 64(7):382-7. doi: . [PMID: 11584575]
  • M Ishibashi, H Oda, M Mitamura, E Okuyama, K Komiyama, K Kawaguchi, T Watanabe, S de Mello Alves, T Maekawa, K Ohtsuki. Casein kinase II inhibitors isolated from two Brazilian plants Hymenaea parvifolia and Wulffia baccata. Bioorganic & medicinal chemistry letters. 1999 Aug; 9(15):2157-60. doi: 10.1016/s0960-894x(99)00351-0. [PMID: 10465536]
  • Q Xu, F Wu, J Cao, T Chen, J Jiang, I Saiki, A Koda. Astilbin selectively induces dysfunction of liver-infiltrating cells--novel protection from liver damage. European journal of pharmacology. 1999 Jul; 377(1):93-100. doi: 10.1016/s0014-2999(99)00401-x. [PMID: 10448932]
  • Y Yi, Z Cao, D Yang, Y Cao, Y Wu, S Zhao. [Studies on the chemical constituents of Smilax glabra]. Yao xue xue bao = Acta pharmaceutica Sinica. 1998 Nov; 33(11):873-5. doi: ". [PMID: 12016952]
  • T Motoyashiki, M Miyake, T Morita, K Mizutani, H Masuda, H Ueki. Enhancement of the vanadate-stimulated release of lipoprotein lipase activity by astilbin from the leaves of Engelhardtia chrysolepis. Biological & pharmaceutical bulletin. 1998 May; 21(5):517-9. doi: 10.1248/bpb.21.517. [PMID: 9635510]
  • D Closa, M Torres, G Hotter, G Bioque, O S León, E Gelpí, J Rósello-Catafau. Prostanoids and free radicals in Cl4C-induced hepatotoxicity in rats: effect of astilbin. Prostaglandins, leukotrienes, and essential fatty acids. 1997 Apr; 56(4):331-4. doi: 10.1016/s0952-3278(97)90578-0. [PMID: 9150380]
  • H Haraguchi, I Ohmi, H Masuda, Y Tamura, K Mizutani, O Tanaka, W H Chou. Inhibition of aldose reductase by dihydroflavonols in Engelhardtia chrysolepis and effects on other enzymes. Experientia. 1996 Jun; 52(6):564-7. doi: 10.1007/bf01969729. [PMID: 8698090]
  • H Haraguchi, Y Mochida, S Sakai, H Masuda, Y Tamura, K Mizutani, O Tanaka, W H Chou. Protection against oxidative damage by dihydroflavonols in Engelhardtia chrysolepis. Bioscience, biotechnology, and biochemistry. 1996 Jun; 60(6):945-8. doi: 10.1271/bbb.60.945. [PMID: 8695910]
  • G Chen, L Shen, P Jiang. [Flavanonol glucosides of Smilax glabra Roxb]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1996 Jun; 21(6):355-7, 383. doi: ". [PMID: 9388924]
  • K Igarashi, Y Uchida, N Murakami, K Mizutani, H Masuda. Effect of astilbin in tea processed from leaves of Engelhardtia chrysolepis on the serum and liver lipid concentrations and on the erythrocyte and liver antioxidative enzyme activities of rats. Bioscience, biotechnology, and biochemistry. 1996 Mar; 60(3):513-5. doi: 10.1271/bbb.60.513. [PMID: 8901115]