Perlolyrine (BioDeep_00000861170)

代谢物信息卡片

InChI=1\C16H12N2O2\c19-9-10-5-6-14(20-10)16-15-12(7-8-17-16)11-3-1-2-4-13(11)18-15\h1-8,18-19H,9H

化学式: C16H12N2O2 (264.0898732)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C3=C(N2)C(=NC=C3)C4=CC=C(O4)CO
InChI: InChI=1S/C16H12N2O2/c19-9-10-5-6-14(20-10)16-15-12(7-8-17-16)11-3-1-2-4-13(11)18-15/h1-8,18-19H,9H2

描述信息

同义名列表

12 个代谢物同义名

Perlolyrine; InChI=1\C16H12N2O2\c19-9-10-5-6-14(20-10)16-15-12(7-8-17-16)11-3-1-2-4-13(11)18-15\h1-8,18-19H,9H; [5-(9H-pyrido[3,4-b]indol-1-yl)furan-2-yl]methanol; [5-(9H-pyrido[3,4-b]indol-1-yl)-2-furyl]methanol; 2-Furanmethanol, 5-(9H-pyrido(3,4-b)indol-1-yl)-; [5-(9H-beta-Carbolin-1-yl)-2-furyl]methanol; [5-(9H-$b-carbolin-1-yl)-2-furyl]methanol; 2-Dehydrocarbonylflazin; 100041-67-6; CCRIS 4068; 29700-20-7; C09231

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:69444
KEGG: C09231
PubChem: 160179
ChEMBL: CHEMBL501991
CAS: 29700-20-7
MetaboLights: MTBLC69444
PubChem: 11422
KNApSAcK: C00001756
3DMET: B02787
NIKKAJI: J21.678J
RefMet: Perlolyrine

分类词条

Carboline alkaloids

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
86864 - Codonopsis pilosula: 10.1016/S0021-9673(01)89657-6
82528 - Crocus sativus: 10.1021/NP0302854
2689076 - Ligusticum chuanxiong: 10.4268/CJCMM20111013
1508160 - Ligusticum striatum: 10.4268/CJCMM20111013
4522 - Lolium perenne: 10.1039/J39700001091
112883 - Lycium chinense: 10.1007/BF02856498
72228 - Ophiocordyceps sinensis: 10.1021/NP100902F
355332 - Polygala tenuifolia: 10.1007/BF02856497
1883 - Streptomyces:
210369 - Tribulus terrestris: 10.1016/S0031-9422(97)01086-8
86864 - 党参: -
33090 - 川芎: -
33090 - 枳椇子: -
33090 - 罗汉果: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Hongbo Zheng, Yifeng Wu, Bin Sun, Chuanle Cheng, Yanan Qiao, Yuehua Jiang, Shengtian Zhao, Zhiyu Xie, Jing Tan, Hongxiang Lou. Discovery of furyl/thienyl β-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect. European journal of medicinal chemistry. 2018 Oct; 158(?):767-780. doi: 10.1016/j.ejmech.2018.09.028. [PMID: 30245400]
Hongbo Zheng, Lin Li, Bin Sun, Yun Gao, Wei Song, Xiaoyu Zhao, Yanhui Gao, Zhiyu Xie, Nianzhao Zhang, Jianbo Ji, Huiqing Yuan, Hongxiang Lou. Design and synthesis of furyl/thineyl pyrroloquinolones based on natural alkaloid perlolyrine, lead to the discovery of potent and selective PDE5 inhibitors. European journal of medicinal chemistry. 2018 Apr; 150(?):30-38. doi: 10.1016/j.ejmech.2018.02.039. [PMID: 29505934]
Jongmin Ahn, Hee-Sung Chae, Young-Won Chin, Jinwoong Kim. Alkaloids from aerial parts of Houttuynia cordata and their anti-inflammatory activity. Bioorganic & medicinal chemistry letters. 2017 06; 27(12):2807-2811. doi: 10.1016/j.bmcl.2017.04.072. [PMID: 28499733]
G H Tang, G H Jiang, L F Zheng. Pharmacokinetics of perlolyrine in rats by stable isotope dilution in conjunction with GC-MS. Acta pharmacologica Sinica. 2000 Jul; 21(7):660-2. doi: NULL. [PMID: 11360678]
G Jiang, G Tang, S Wang, C Wang, L Zheng. [Studies on urinary metabolites of perlolyrine in rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 2000 Apr; 22(2):154-8. doi: ". [PMID: 12903518]