NPI 031L (BioDeep_00000859693)

PANOMIX_OTCML-2023 BioNovoGene_Lab2019

代谢物信息卡片

4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-

化学式: C15H10O5 (270.052821)
中文名称: 染料木素, 金雀异黄酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O
InChI: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

描述信息

C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1821 - Selective Estrogen Receptor Modulator
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D000970 - Antineoplastic Agents
C1892 - Chemopreventive Agent
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

同义名列表

95 个代谢物同义名

4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one; 5-18-04-00594 (Beilstein Handbook Reference); Genistein; 4,5,7-Trihydroxyisoflavone; ISOFLAVONE, 4,5,7-TRIHYDROXY-; 4′,5,7-Trihydroxyisoflavone; 4,5,7-Trihydroxy isoflavone; 5,7,4-Trihydroxyisoflavone; 4,5,7-Trihydroxyisoflavone; 4,6,7-Trihydroxyisoflavone; nchembio.2007.28-comp32; Lactoferrin-genistein; nchembio.76-comp6; Spectrum5_000106; UPCMLD-DP096:001; Spectrum4_001543; EINECS 207-174-9; Spectrum2_000638; Spectrum3_000678; NCGC00025005-04; NCGC00015479-02; SpecPlus_000305; NCGC00025005-01; NCGC00025005-02; NCGC00025005-07; Spectrum_000320; NCGC00015479-01; NCGC00025005-05; SPECTRUM210296; KBioSS_000800; KBioGR_002564; KBioSS_002573; DivK1c_006401; MolMap_000022; MEGxp0_000568; Oprea1_224620; Lopac0_000520; Oprea1_437815; BSPBio_002375; KBioGR_002006; Differenol A; KBio2_003368; Lopac-G-6649; KBio2_002564; KBio3_003042; KBio1_001345; SMR000112580; SPBio_000636; ACon1_001065; KBio2_007700; KBio3_001595; ZINC00041692; NCI60_003369; KBio2_005936; MLS000738127; KBio2_000800; KBio2_005132; AIDS-097204; CHEBI:28088; AIDS-016499; G6776_SIGMA; BRN 0263823; Bio1_000445; G6649_SIGMA; cMAP_000086; Tocris-1110; Bio1_000934; Bio1_001423; SMP1_000133; AIDS097204; Sophoricol; EU-0100520; C.I. 75610; Genisterin; AIDS016499; CCRIS 7675; SIPI 807-1; PTI G4660; NSC 36586; Genisteol; Genistein; TNP00151; NSC36586; NPI 031L; ST056352; 446-72-0; Prunetol; K00046; STO514; C06563; GEN; Genistein

数据库引用编号

17 个数据库交叉引用编号

ChEBI: CHEBI:28088
KEGG: C06563
PubChem: 5280961
DrugBank: DB01645
ChEMBL: CHEMBL44
MeSH: Genistein
CAS: 690224-00-1
CAS: 446-72-0
PubChem: 8792
LipidMAPS: LMPK12050218
KNApSAcK: C00002526
PDB-CCD: GEN
3DMET: B00974
NIKKAJI: J39.883G
medchemexpress: HY-14596
BioNovoGene_Lab2019: BioNovoGene_Lab2019-754
KNApSAcK: 28088

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

255 个相关的物种来源信息

204988 - Acacia adunca:
383632 - Acacia baileyana:
138512 - Acacia binervata:
139006 - Acacia calamifolia:
383638 - Acacia cardiophylla:
1174753 - Acacia chrysotricha:
1174755 - Acacia clunies-rossiae:
1173642 - Acacia concurrens:
383640 - Acacia constablei:
138515 - Acacia cultriformis:
205042 - Acacia dealbata:
205356 - Acacia deanei:
205044 - Acacia decurrens:
138021 - Acacia elata:
139008 - Acacia falciformis:
383643 - Acacia filicifolia:
21010 - Acacia fimbriata:
1120455 - Acacia holosericea:
383645 - Acacia irrorata:
1378370 - Acacia kettlewelliae:
138518 - Acacia leucoclada:
139010 - Acacia longifolia:
383647 - Acacia mabellae:
139012 - Acacia mearnsii:
138028 - Acacia melanoxylon:
383648 - Acacia mollifolia:
205053 - Acacia neriifolia:
866003 - Acacia obtusifolia:
383653 - Acacia oshanesii:
139013 - Acacia oswaldii:
138037 - Acacia parramattensis:
880440 - Acacia pycnantha:
1050817 - Acacia retinodes:
694556 - Acacia rigens:
205063 - Acacia silvestris:
383657 - Acacia terminalis:
383658 - Acacia trachyphloia:
1120475 - Acacia verniciflua:
1120476 - Acacia vestita:
63345 - Achlys triphylla: 10.1021/NP50099A032
126911 - Ammopiptanthus mongolicus: 10.1002/HLCA.200890108
53825 - Andira inermis:
185702 - Apios americana: 10.1016/0031-9422(82)80152-0
7460 - Apis mellifera: 10.3390/IJMS15022327
3818 - Arachis hypogaea: 10.1021/JF062148T
1009002 - Ardisia paniculata: 10.1016/J.BMC.2008.12.033
2014735 - Astragalus verrucosus: 10.1016/S0367-326X(02)00087-4
313911 - Baptisia alba:
149633 - Baptisia australis:
313912 - Baptisia bracteata:
1969220 - Baptisia calycosa:
313913 - Baptisia cinerea:
1969221 - Baptisia lanceolata:
1969222 - Baptisia lecontei:
1969223 - Baptisia megacarpa:
1871516 - Baptisia perfoliata:
49797 - Baptisia tinctoria:
53838 - Bolusanthus speciosus:
595543 - Bowdichia nitida: 10.1002/JLAC.197419740816
56060 - Butea monosperma: 10.1016/J.BMCL.2008.12.064
480422 - Butea superba: 10.3987/COM-05-10350
3821 - Cajanus cajan: 10.1016/0031-9422(79)80111-9
669084 - Cajanus scarabaeoides: 10.1016/0031-9422(79)80111-9
49799 - Calicotome villosa: 10.1016/S0367-326X(03)00061-3
49807 - Chamaecytisus supinus: 10.1021/NP50050A058
3827 - Cicer arietinum:
247908 - Cladrastis platycarpa: 10.1021/NP50068A037
539006 - Craspedolobium schochii: 10.1016/S0367-326X(00)00218-5
1672627 - Craspedolobium unijugum: 10.1016/S0367-326X(00)00218-5
3830 - Crotalaria pallida: 10.1021/NP020135D
890035 - Crotalaria pallida var. obovata: 10.1080/10826079208016365
165774 - Crotalaria retusa: 10.1080/10826079208016365
1978221 - Crotalaria thebaica: 10.21608/BFSA.2000.66404
429560 - Cullen corylifolium: 10.1093/CHROMSCI/39.10.441
450026 - Dalbergia frutescens: 10.1021/NP000010D
1030150 - Dalbergia oliveri: 10.1016/J.PHYTOCHEM.2003.08.010
1353466 - Dalbergia parviflora: 10.1021/NP900676Y
107308 - Dalbergia sissoo:
149639 - Dermatophyllum secundiflorum:
225101 - Desmodium uncinatum:
1977554 - Desmodium velutinum: 10.1080/10826079208016365
238419 - Echinospartum horridum: 10.1016/S0031-9422(00)94255-9
2828540 - Eriosema tuberosum: 10.1016/S0031-9422(97)00950-3
2590687 - Erythrina burttii:
556509 - Erythrina fusca: 10.1016/J.FITOTE.2010.01.009
3844 - Erythrina latissima:
3845 - Erythrina variegata:
256638 - Euchresta formosana:
309266 - Ficus cordata:
182114 - Ficus glumosa: 10.1590/S0103-50532012000300015
463862 - Ficus nervosa: 10.1002/CBDV.200900227
182120 - Ficus nymphaeifolia:
66386 - Ficus pumila: 10.1016/S0305-1978(99)00064-2
100573 - Ficus septica:
520843 - Flemingia macrophylla:
2595086 - Flemingia paniculata: 10.1021/NP0206108
1009475 - Garcinia oblongifolia: 10.1016/0031-9422(95)00041-5
274560 - Genista acanthoclada: 10.1021/NP980112S
319658 - Genista albida: 10.1021/NP980112S
176347 - Genista anglica: 10.1021/NP980112S
49847 - Genista canariensis: 10.1021/NP980112S
123905 - Genista ephedroides: 10.1021/NP980112S
238491 - Genista hispanica: 10.1021/NP980112S
238493 - Genista hystrix: 10.1021/NP980112S
1642312 - Genista lobelii: 10.1021/NP980112S
175408 - Genista microphylla: 10.1021/NP980112S
49848 - Genista monspessulana: 10.1021/NP980112S
238500 - Genista obtusiramea: 10.1021/NP980112S
274574 - Genista pulchella: 10.1021/NP980112S
136799 - Genista radiata: 10.1021/NP980112S
49809 - Genista sagittalis: 10.1021/NP980112S
274575 - Genista salzmannii: 10.1021/NP980112S
238509 - Genista scorpius: 10.1021/NP980112S
238510 - Genista sericea: 10.1021/NP980112S
147456 - Genista sessilifolia:
123911 - Genista spartioides: 10.1021/NP980112S
49825 - Genista tinctoria:
238516 - Genista triacanthos: 10.1021/NP980112S
49826 - Genista tricuspidata: 10.1007/S10600-006-0264-6
238518 - Genista tridens: 10.1021/NP980112S
49810 - Genista tridentata:
1784780 - Genista ulicina: 10.1021/NP980112S
3846 - Glycine:
48924 - Glycine canescens: 10.1016/0305-1978(84)90033-4
45687 - Glycine clandestina: 10.1016/0305-1978(84)90033-4
45690 - Glycine falcata: 10.1016/0305-1978(84)90033-4
45691 - Glycine latifolia: 10.1016/0305-1978(84)90033-4
3847 - Glycine max:
44016 - Glycine tabacina: 10.1016/0305-1978(84)90033-4
44015 - Glycine tomentella: 10.1016/0305-1978(84)90033-4
46347 - Glycyrrhiza: 10.1248/CPB.39.1238
49827 - Glycyrrhiza glabra:
74613 - Glycyrrhiza uralensis: 10.1248/CPB.48.1286
648866 - Grona styracifolia:
9606 - Homo sapiens:
1137022 - Hypericum scabrum: 10.1021/NP040024+
58944 - Iris domestica:
82213 - Iris pseudacorus: 10.1016/0031-9422(91)84117-B
35936 - Lablab purpureus: 10.1515/ZNC-1977-11-1225
49828 - Laburnum anagyroides: 10.1016/0031-9422(95)00029-7
701533 - Lespedeza cyrtobotrya:
587870 - Lespedeza floribunda:
688283 - Lespedeza juncea: 10.1248/CPB.28.1172
1421005 - Lonchocarpus utilis: 10.1073/PNAS.95.7.3380
3870 - Lupinus albus:
3871 - Lupinus angustifolius: 10.1007/BF01020159
3872 - Lupinus arboreus:
53215 - Lupinus arcticus:
53225 - Lupinus digitatus:
53226 - Lupinus elegans:
3873 - Lupinus luteus:
53232 - Lupinus mutabilis:
53233 - Lupinus nanus:
53237 - Lupinus pilosus:
3874 - Lupinus polyphyllus: 10.1515/ZNC-1991-9-1003
53240 - Lupinus pubescens: 10.21608/BFSA.2000.66325
61075 - Lupinus sericeus:
28959 - Lupinus texensis:
37501 - Maackia amurensis:
194324 - Maclura cochinchinensis:
210328 - Maclura tricuspidata:
3879 - Medicago sativa:
103823 - Neonotonia wightii: 10.1016/0031-9422(77)80101-5
1888375 - Neorautanenia amboensis: 10.1021/NP50048A006
167620 - Neorautanenia mitis: 10.1021/NP50048A006
109224 - Neustanthus phaseoloides:
58890 - Ononis spinosa:
72228 - Ophiocordyceps sinensis: 10.1021/NP100902F
705300 - Ormosia henryi: 10.1016/J.FITOTE.2011.10.007
1993839 - Ormosia monosperma: 10.1016/S0031-9422(00)90378-9
2044332 - Ougeinia dalbergioides: 10.1002/PCA.646
1929974 - Pericopsis laxiflora: 10.1039/P19760000186
3886 - Phaseolus coccineus: 10.1016/S0031-9422(00)80697-4
3884 - Phaseolus lunatus:
3885 - Phaseolus vulgaris:
88728 - Pinus koraiensis:
62123 - Piscidia piscipula: 10.1016/S0031-9422(00)90825-2
33090 - Plants: -
2816372 - Platyosprion platycarpum: 10.1021/NP50068A037
670324 - Pleurolobus gangeticus:
46147 - Portulaca oleracea: 10.1002/HLCA.201000250
42229 - Prunus avium: 10.1021/JA01559A059
378224 - Prunus cerasoides: 10.1021/NP50050A020
140311 - Prunus cerasus: 10.1021/JF980936F
105666 - Prunus leveilleana: 10.1021/JA01559A059
97306 - Prunus maximowiczii: 10.1021/JA01559A059
137737 - Prunus nipponica: 10.1021/JA01559A059
140663 - Prunus verecunda: 10.1021/JA01559A059
286 - Pseudomonas: 10.7164/ANTIBIOTICS.39.606
182271 - Pterocarpus angolensis: 10.1039/P19810000263
100170 - Pterocarpus indicus: 10.1039/P19810000263
1071187 - Pterocarpus marsupium: 10.1039/P19810000263
3892 - Pueraria: 10.1016/J.BBRC.2008.10.178
861244 - Pueraria candollei var. mirifica:
174648 - Pueraria montana var. thomsonii:
457826 - Pueraria tuberosa:
22663 - Punica granatum:
254911 - Saussurea japonica: 10.1021/NP9603941
200492 - Sophora alopecuroides: 10.1007/BF02249700
49840 - Sophora flavescens:
149668 - Sophora pachycarpa: 10.1007/BF00575192
714503 - Sophora tonkinensis:
714503 - Sophora tonkinensis Gagnep.: -
49843 - Spartium junceum: 10.1007/BF00579059
455371 - Spatholobus suberectus: 10.3184/174751918X15386515371813
455371 - Spatholobus Suberectus Dunn: -
1231571 - Spirotropis longifolia: 10.1016/J.PHYTOCHEM.2011.10.011
13274 - Stellaria media: 10.1016/J.HELIYON.2020.E04150
1883 - Streptomyces:
67294 - Streptomyces filamentosus: 10.1080/14786419.2018.1484457
1911 - Streptomyces griseus: 10.1021/NP50088A016
67385 - Streptomyces xanthophaeus: 10.1080/14786419.2016.1269100
46190 - Streptosporangium vulgare: 10.1271/BBB1961.51.3003
3897 - Styphnolobium japonicum:
334483 - Syzygium jambos: 10.1002/(SICI)1099-1565(199707)8:4<176::AID-PCA351>3.0.CO;2-K
49853 - Thermopsis fabacea: 10.1248/CPB.28.3686
114320 - Thermopsis lanceolata: 10.1248/CPB.28.3686
114322 - Thermopsis macrophylla:
2805045 - Thermopsis mollis:
183296 - Thermopsis montana: 10.1016/0031-9422(90)80146-8
61122 - Thermopsis rhombifolia:
114325 - Thermopsis villosa:
691243 - Thomsonaria thomsonii:
97007 - Trifolium alpestre:
361560 - Trifolium arvense: 10.1016/J.TALANTA.2009.03.011
361561 - Trifolium aureum: 10.1007/BF00579982
97023 - Trifolium fragiferum: 10.1021/JF00049A020
60916 - Trifolium incarnatum:
97028 - Trifolium medium: 10.1016/J.TALANTA.2009.03.011
74522 - Trifolium montanum: 10.1021/JF00049A020
97032 - Trifolium pannonicum: 10.1016/J.TALANTA.2009.03.011
57577 - Trifolium pratense:
3899 - Trifolium repens:
97037 - Trifolium rubens: 10.1016/J.TALANTA.2009.03.011
3900 - Trifolium subterraneum:
3902 - Ulex europaeus: 10.1016/0031-9422(90)85444-K
183290 - Ulex gallii: 10.1016/0031-9422(90)85444-K
3915 - Vigna mungo: 10.1515/ZNC-1984-9-1006
157791 - Vigna radiata: 10.1515/ZNC-1983-9-1004
185975 - Wisteria brachybotrys: 10.1016/0031-9422(88)80628-9
54882 - Wisteriopsis reticulata: 10.1021/JF903216R
4577 - Zea mays:
33090 - 天葵子: -
33090 - 射干: -
33090 - 山豆根: -
33090 - 川射干: -
33090 - 杜仲: -
33090 - 槐角: -
33090 - 淡豆豉: -
33090 - 肉苁蓉: -
33090 - 芫花: -
33090 - 葛根: -
33090 - 葛花: -
33090 - 鸡血藤: -
33090 - 黑豆: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Gaoxuan Shao, Ying Liu, Lu Lu, Lei Wang, Guang Ji, Hanchen Xu. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug. Journal of ethnopharmacology. 2024 Jun; 327(?):117999. doi: 10.1016/j.jep.2024.117999. [PMID: 38447616]
Palash Mandal, David A Mortensen, André F Brito, Anna K Wallingford, Marta R M Lima, Nicholas D Warren, Richard G Smith. Water Stress Influences Phytoestrogen Levels in Red Clover (Trifolium pratense) but Not Kura Clover (T. ambiguum). Journal of agricultural and food chemistry. 2024 May; 72(18):10247-10256. doi: 10.1021/acs.jafc.4c00300. [PMID: 38683760]
Xue Li, Le Liu, Mei-Xuan Wan, Li-Min Gong, Juan Su, Li Xu. Active Components of Pueraria lobata through the MAPK/ERK Signaling Pathway Alleviate Iron Overload in Alcoholic Liver Disease. Chemistry & biodiversity. 2024 May; 21(5):e202400005. doi: 10.1002/cbdv.202400005. [PMID: 38504590]
Yaning Wu, Hongwei Zhang, Jianguang Zhu, Zhenling Zhang, Songbo Ma, Yongqi Zhao, Yiming Wang, Jun Yuan, Xing Guo, Yajing Li, Shuai Zhang. The Effect of Fermentation on the Chemical Constituents of Gastrodia Tuber Hallimasch Powder (GTHP) Estimated by UHPLC-Q-Orbitrap HRMS and HPLC. Molecules (Basel, Switzerland). 2024 Apr; 29(7):. doi: 10.3390/molecules29071663. [PMID: 38611942]
Yun Bo Zhang, Jiang Li Li, Jie Tian, Xiao Lin Na. Effect of Maternal DEHP Exposure on Lipid Metabolism in Adult Male Rats and the Antagonistic Effect of Genistein. Biomedical and environmental sciences : BES. 2024 Mar; 37(3):315-319. doi: 10.3967/bes2024.034. [PMID: 38582995]
Jamie Gudyka, Jasmin Ceja-Vega, Katherine Ivanchenko, Wilber Perla, Christopher Poust, Alondra Gamez Hernandez, Colleen Clarke, Shakinah Silverberg, Escarlin Perez, Sunghee Lee. Differential Effects of Soy Isoflavones on the Biophysical Properties of Model Membranes. The journal of physical chemistry. B. 2024 Mar; 128(10):2412-2424. doi: 10.1021/acs.jpcb.3c08390. [PMID: 38417149]
Magdalena Wójciak, Piotr Drozdowski, Aleksandra Ziemlewska, Martyna Zagórska-Dziok, Zofia Nizioł-Łukaszewska, Tomasz Kubrak, Ireneusz Sowa. ROS Scavenging Effect of Selected Isoflavones in Provoked Oxidative Stress Conditions in Human Skin Fibroblasts and Keratinocytes. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29050955. [PMID: 38474467]
Nopawit Khamto, Kraikrit Utama, Panida Boontawee, Atchara Janthong, Suriya Tatieng, Supakorn Arthan, Vachira Choommongkol, Padchanee Sangthong, Chavi Yenjai, Nuttee Suree, Puttinan Meepowpan. Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLpro: Insights from the Computational and Experimental Investigations. Journal of chemical information and modeling. 2024 Jan; ?(?):. doi: 10.1021/acs.jcim.3c01477. [PMID: 38277124]
Eman Shawky, Rasha A Nassra, Aliaa M T El-Alkamy, Shaimaa M Sallam, Samah M El Sohafy. Unraveling the mechanisms of Fenugreek seed for managing different gynecological disorders: steroidal saponins and isoflavones revealed as key bioactive metabolites. Journal of pharmaceutical and biomedical analysis. 2024 Jan; 238(?):115865. doi: 10.1016/j.jpba.2023.115865. [PMID: 38000191]
Ida K L Andersen, Inge S Fomsgaard, Jim Rasmussen. Intercropping of Narrow-Leafed Lupin (Lupinus angustifolius L.) and Barley (Hordeum vulgare L.) Affects the Flavonoid Composition of Both Crops. Journal of agricultural and food chemistry. 2024 Jan; 72(1):108-115. doi: 10.1021/acs.jafc.3c03684. [PMID: 38146912]
Canhong Wang, Bao Gong, Yulan Wu, Congwen Bai, Meihua Yang, Xiangsheng Zhao, Jianhe Wei. Pharmacokinetics and molecular docking of the cardioprotective flavonoids in Dalbergia odorifera. Journal of separation science. 2024 Jan; 47(1):e2300614. doi: 10.1002/jssc.202300614. [PMID: 38066409]
Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma. Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens. Poultry science. 2024 Jan; 103(1):103251. doi: 10.1016/j.psj.2023.103251. [PMID: 37984004]
Yilin Chen, Fengwei Zhang, Jijia Sun, Lei Zhang. Identifying the natural products in the treatment of atherosclerosis by increasing HDL-C level based on bioinformatics analysis, molecular docking, and in vitro experiment. Journal of translational medicine. 2023 Dec; 21(1):920. doi: 10.1186/s12967-023-04755-7. [PMID: 38115108]
Worapol Sae-Foo, Sukritta Singkham, Pimsiri Srisongkhram, Gorawit Yusakul, Pisitchai Masugarut, Waraporn Putalun. Development and characterisation of highly specific monoclonal antibody-based immunoassays for the detection and quantification of genistein-7-O-[α-rhamnopyranosyl-(1→6)]-β-glucopyranoside in Derris scandens (Roxb.) Benth. Phytochemical analysis : PCA. 2023 Nov; ?(?):. doi: 10.1002/pca.3305. [PMID: 37965872]
Haruna Nagayoshi, Norie Murayama, Vitchan Kim, Donghak Kim, Shigeo Takenaka, Hiroshi Yamazaki, F Peter Guengerich, Tsutomu Shimada. Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. Chemical research in toxicology. 2023 Oct; ?(?):. doi: 10.1021/acs.chemrestox.3c00229. [PMID: 37783573]
Tong Xuan, Yuhan Liu, Rui Liu, Sheng Liu, Jiaqi Han, Xinyu Bai, Jie Wu, Ronghua Fan. Advances in Extraction, Purification, and Analysis Techniques of the Main Components of Kudzu Root: A Comprehensive Review. Molecules (Basel, Switzerland). 2023 Sep; 28(18):. doi: 10.3390/molecules28186577. [PMID: 37764353]
Shun Watanabe, Riki Haruyama, Koji Umezawa, Ikuo Tomioka, Soichiro Nakamura, Shigeru Katayama, Takakazu Mitani. Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes. The Journal of nutritional biochemistry. 2023 Aug; 121(?):109433. doi: 10.1016/j.jnutbio.2023.109433. [PMID: 37648097]
Yaoyao Ren, Shengtao Qu. Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies. Ageing research reviews. 2023 Aug; 90(?):102040. doi: 10.1016/j.arr.2023.102040. [PMID: 37619620]
Yi Wei, Yongfa Liu, Guang Li, Yuming Guo, Bingkun Zhang. Effects of quercetin and genistein on egg quality, lipid profiles and immunity in laying hens. Journal of the science of food and agriculture. 2023 Aug; ?(?):. doi: 10.1002/jsfa.12910. [PMID: 37552763]
Gabriella Magarelli, Cínthia Caetano Bonatto, Gabriela Mendes da Rocha Vaz, Victoria Baggi Mendonça Lauria, Luciano Paulino Silva. Unveiling the Remarkable Antioxidant Activity of Plant-Based Fish and Seafood Analogs through Electrochemical Sensor Analysis. Biosensors. 2023 Jul; 13(7):. doi: 10.3390/bios13070751. [PMID: 37504149]
Fei Teng, Zhongwen Lu, Fei Gao, Jing Liang, Jiawen Li, Xuanhe Tian, Xianshuai Wang, Haowei Guan, Jin Wang. Systems biology approaches to identify potential targets and inhibitors of the intestinal microbiota to treat depression. Scientific reports. 2023 07; 13(1):11225. doi: 10.1038/s41598-023-38444-8. [PMID: 37433869]
Ana Ruiz de la Bastida, Susana Langa, Ángela Peirotén, Raúl Fernández-Gonzalez, Abel Sánchez-Jiménez, María Maroto, José Antonio Curiel, Eva Guillamon, Juan Luis Arqués, Alfonso Gutiérrez-Adán, José María Landete. Effect of fermented soy beverage in aged female mice model. Food research international (Ottawa, Ont.). 2023 07; 169(?):112745. doi: 10.1016/j.foodres.2023.112745. [PMID: 37254374]
Iskandar Azmy Harahap, Maciej Kuligowski, Marcin Schmidt, Joanna Suliburska. The impact of soy products, isoflavones, and Lactobacillus acidophilus on iron status and morphological parameters in healthy female rats. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2023 Jul; 78(?):127183. doi: 10.1016/j.jtemb.2023.127183. [PMID: 37120971]
Longlong Li, Yulei Wang, Huihui Wang, Ying Yang, Haitian Ma. Protective effects of genistein on the production performance and lipid metabolism disorders in laying hens with fatty liver hemorrhagic syndrome by activation of the GPER-AMPK signaling pathways. Journal of animal science. 2023 Jun; ?(?):. doi: 10.1093/jas/skad197. [PMID: 37314978]
Chiagoziem A Otuechere, Netra P Neupane, Adewale Adewuyi, Prateek Pathak, Jurica Novak, Maria Grishina, Habibullah Khalilullah, Mariusz Jaremko, Amita Verma. Green Synthesis of Genistein-Fortified Zinc Ferrite Nanoparticles as a Potent Hepatic Cancer Inhibitor: Validation through Experimental and Computational Studies. Chemistry & biodiversity. 2023 Jun; ?(?):e202300719. doi: 10.1002/cbdv.202300719. [PMID: 37312449]
Arthur Neuberger, Yury A Trofimov, Maria V Yelshanskaya, Kirill D Nadezhdin, Nikolay A Krylov, Roman G Efremov, Alexander I Sobolevsky. Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nature communications. 2023 May; 14(1):2659. doi: 10.1038/s41467-023-38352-5. [PMID: 37160865]
Lijuan Shi, Zhen Lin, Jiantong Hou, Wenhui Liu, Jing Xu, Yuanqiang Guo. Purification and characterization of chicory polysaccharide and its application in stabling genistein for cancer therapy. International journal of biological macromolecules. 2023 Apr; ?(?):124635. doi: 10.1016/j.ijbiomac.2023.124635. [PMID: 37121414]
Hong Qin, Ziyu Song, Chunyu Zhao, Sha Li, Anwar Ali, Wenya Zheng. miR-363-3p/PTEN is involved in the regulation of lipid metabolism by genistein in HepG2 cells via ERβ. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Apr; 115(?):154839. doi: 10.1016/j.phymed.2023.154839. [PMID: 37121060]
Dionysios T Pavlopoulos, Eleni D Myrtsi, Paschalitsa Tryfinopoulou, Vasilios Iliopoulos, Sofia D Koulocheri, Serkos A Haroutounian. Phytoestrogens as Biomarkers of Plant Raw Materials Used for Fish Feed Production. Molecules (Basel, Switzerland). 2023 Apr; 28(8):. doi: 10.3390/molecules28083623. [PMID: 37110857]
Mohd Farhan, Mohamed El Oirdi, Mohammad Aatif, Insha Nahvi, Ghazala Muteeb, Mir Waqas Alam. Soy Isoflavones Induce Cell Death by Copper-Mediated Mechanism: Understanding Its Anticancer Properties. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28072925. [PMID: 37049690]
Masahiko Taniguchi, Connor A LaRocca, Jake D Bernat, Jonathan S Lindsey. Digital Database of Absorption Spectra of Diverse Flavonoids Enables Structural Comparisons and Quantitative Evaluations. Journal of natural products. 2023 Feb; ?(?):. doi: 10.1021/acs.jnatprod.2c00720. [PMID: 36848595]
Tingting Chen, Juan Wang, Min Li, Qingqing Wu, Shuna Cui. Genistein Inhibits Proliferation and Metastasis in Human Cervical Cancer Cells through the Focal Adhesion Kinase Signaling Pathway: A Network Pharmacology-Based In Vitro Study in HeLa Cells. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041919. [PMID: 36838908]
Nithiwat Suntichaikamolkul, Tomoyoshi Akashi, Panupong Mahalapbutr, Kamonpan Sanachai, Thanyada Rungrotmongkol, Jean-Etienne Bassard, Hubert Schaller, Wanchai De-Eknamkul, Sornkanok Vimolmangkang, Mami Yamazaki, Supaart Sirikantaramas. Daidzein Hydroxylation by CYP81E63 Is Involved in the Biosynthesis of Miroestrol in Pueraria mirifica. Plant & cell physiology. 2023 Feb; 64(1):64-79. doi: 10.1093/pcp/pcac140. [PMID: 36218384]
Tharindu L Suraweera, J P Jose Merlin, Graham Dellaire, Zhaolin Xu, H P Vasantha Rupasinghe. Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in Bronchial Epithelial Cells In Vitro. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043676. [PMID: 36835090]
Mengying Wang, Biying Dong, Zhihua Song, Meng Qi, Ting Chen, Tingting Du, Hongyan Cao, Ni Liu, Dong Meng, Qing Yang, Yujie Fu. Molecular mechanism of naringenin regulation on flavonoid biosynthesis to improve the salt tolerance in pigeon pea (Cajanus cajan (Linn.) Millsp.). Plant physiology and biochemistry : PPB. 2023 Feb; 196(?):381-392. doi: 10.1016/j.plaphy.2023.02.002. [PMID: 36746009]
Xinyi Guo. Antibacterial and anti-inflammatory effects of genistein in Staphylococcus aureus induced osteomyelitis in rats. Journal of biochemical and molecular toxicology. 2023 Feb; ?(?):e23298. doi: 10.1002/jbt.23298. [PMID: 36727417]
Parth Malik, Raj Singh, Mukesh Kumar, Anuj Malik, Tapan Kumar Mukherjee. Understanding the phytoestrogen genistein actions on breast cancer: Insights on estrogen receptor equivalence, pleiotropic essence and emerging paradigms in bioavailability modulation. Current topics in medicinal chemistry. 2023 Jan; ?(?):. doi: 10.2174/1568026623666230103163023. [PMID: 36597609]
Yuan Cheng, Yi Tang, Yiming Tan, Juan Li, Xuping Zhang. KCNK9 mediates the inhibitory effects of genistein on hepatic metastasis from colon cancer. Clinics (Sao Paulo, Brazil). 2023; 78(?):100141. doi: 10.1016/j.clinsp.2022.100141. [PMID: 36905879]
Jia Xiang, Ronald Mlambo, Progress Dube, Oleen Machona, Ibrahim Shaw, Yimer Seid, Yongju He, Min Luo, Tingting Hong, Binsheng He, Wenhu Zhou, Songwen Tan. The obesogenic side of Genistein. Frontiers in endocrinology. 2023; 14(?):1308341. doi: 10.3389/fendo.2023.1308341. [PMID: 38098865]
H Y He, H Z Shan, S Q Li, R G Diao. Genistein attenuates renal ischemia-reperfusion injury via ADORA2A pathway. Human & experimental toxicology. 2023 Jan; 42(?):9603271231164913. doi: 10.1177/09603271231164913. [PMID: 36932924]
Zhihao Jiang, Huihui Wang, Ying Yang, Yao Yao, Haitian Ma. Genistein activated SIRT1-AMPK signaling pathway mediated by ERβ-FOXO1-Nampt to reduce fat accumulation in chicken hepatocytes. Life sciences. 2023 Jan; 312(?):121259. doi: 10.1016/j.lfs.2022.121259. [PMID: 36463943]
Jiayang Chen, Li Feng, Wei Jin, Jinyuan Chang, Jie Li, Hao Li. Identification of the Key Active Pharmaceutical Ingredients of Yishen Qutong Granule, A Chinese Medicine Formula, In The Treatment of Primary Lung Cancer. Combinatorial chemistry & high throughput screening. 2023; 26(8):1594-1608. doi: 10.2174/1386207326666221207152001. [PMID: 36503468]
Tomokazu Ohishi, Noriyuki Miyoshi, Mari Mori, Miki Sagara, Yukio Yamori. Health Effects of Soy Isoflavones and Green Tea Catechins on Cancer and Cardiovascular Diseases Based on Urinary Biomarker Levels. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248899. [PMID: 36558031]
Min Chen, Shizhao Li, Itika Arora, Nengjun Yi, Manvi Sharma, Zhenhai Li, Trygve O Tollefsbol, Yuanyuan Li. Maternal soybean diet on prevention of obesity-related breast cancer through early-life gut microbiome and epigenetic regulation. The Journal of nutritional biochemistry. 2022 12; 110(?):109119. doi: 10.1016/j.jnutbio.2022.109119. [PMID: 35933021]
Faryal Rubab, Hira Ijaz, Shah Hussain, Ans Munir, Stefan Stuppner, Thomas Jakschitz, Günther K Bonn, Saiqa Ishtiaq. Gastroprotective effects of Caragana ambigua stocks on ethanol-induced gastric ulcer in rats supported by LC-MS/MS characterization of formononetin and biochanin A. Journal of the science of food and agriculture. 2022 Dec; 102(15):7030-7038. doi: 10.1002/jsfa.12064. [PMID: 35689485]
Zuo-Cheng Qiu, Feng-Xiang Zhang, Xue-Ling Hu, Yang-Yang Zhang, Zi-Ling Tang, Jie Zhang, Li Yang, Man-Sau Wong, Jia-Xu Chen, Hui-Hui Xiao. Genistein Modified with 8-Prenyl Group Suppresses Osteoclast Activity Directly via Its Prototype but Not Metabolite by Gut Microbiota. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27227811. [PMID: 36431913]
B Haridevamuthu, Ajay Guru, Raghul Murugan, Gokul Sudhakaran, Raman Pachaiappan, Mikhlid H Almutairi, Bader O Almutairi, Annie Juliet, Jesu Arockiaraj. Neuroprotective effect of Biochanin a against Bisphenol A-induced prenatal neurotoxicity in zebrafish by modulating oxidative stress and locomotory defects. Neuroscience letters. 2022 Nov; 790(?):136889. doi: 10.1016/j.neulet.2022.136889. [PMID: 36179902]
Matheus Luís Oliveira Cunha, Lara Caroline Alves de Oliveira, Vinicius Martins Silva, Gabriel Sgarbiero Montanha, André Rodrigues Dos Reis. Selenium increases photosynthetic capacity, daidzein biosynthesis, nodulation and yield of peanuts plants (Arachis hypogaea L.). Plant physiology and biochemistry : PPB. 2022 Nov; 190(?):231-239. doi: 10.1016/j.plaphy.2022.08.006. [PMID: 36137309]
Xiaoxue Fang, Yegang Zhang, Yiming Cao, Mengyao Shan, Dimeng Song, Chao Ye, Difu Zhu. Studies on Chemical Composition of Pueraria lobata and Its Anti-Tumor Mechanism. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217253. [PMID: 36364084]
Fumika Kato, Yuka Ando, Aiko Tanaka, Takamasa Suzuki, Daigo Takemoto, Makoto Ojika. Inhibitors of Asexual Reproduction of the Plant Pathogen Phytophthora from Tomato Juice: Structure-Activity Relationships and Transcriptome Analysis. Journal of agricultural and food chemistry. 2022 Oct; 70(40):12878-12884. doi: 10.1021/acs.jafc.2c05556. [PMID: 36190399]
Xian Shao, Xiaofei Chen, Ziyu Wang, Cuicui Zhu, Yan Du, Daoquan Tang, Shuai Ji. Diprenylated flavonoids from licorice induce death of SW480 colorectal cancer cells by promoting autophagy: Activities of lupalbigenin and 6,8-diprenylgenistein. Journal of ethnopharmacology. 2022 Oct; 296(?):115488. doi: 10.1016/j.jep.2022.115488. [PMID: 35728712]
Ana Joyce Coutinho, Marina Pinheiro, Ana Rute Neves, Madalena M M Pinto. Therapeutic potential of genistein: preclinical studies, clinical evidence, and nanotechnology application. Current medicinal chemistry. 2022 Oct; ?(?):. doi: 10.2174/0929867329666221004124800. [PMID: 36200214]
Cheng Lin, Zhiping Liu, Jia Chen, Xuanxuan Wang, Rui Zhang, Longhuo Wu, Linfu Li. Integration of UPLC-QE-MS/MS and network pharmacology to investigate the active components and action mechanisms of tea cake extract for treating cough. Biomedical chromatography : BMC. 2022 Oct; 36(10):e5442. doi: 10.1002/bmc.5442. [PMID: 35781817]
Mohammad Rumman, Shivani Pandey, Babita Singh, Mrinal Gupta, Abbas Ali Mahdi. Genistein suppresses microglial activation and inhibits apoptosis in different brain regions of hypoxia-exposed mice model of amnesia. Metabolic brain disease. 2022 10; 37(7):2521-2532. doi: 10.1007/s11011-022-01039-9. [PMID: 35895244]
Wahid Zada, Jonathan W VanRyzin, Miguel Perez-Pouchoulen, Samantha L Baglot, Matthew N Hill, Ghulam Abbas, Sarah M Clark, Umer Rashid, Margaret M McCarthy, Abdul Mannan. Fatty acid amide hydrolase inhibition and N-arachidonoylethanolamine modulation by isoflavonoids: A novel target for upcoming antidepressants. Pharmacology research & perspectives. 2022 10; 10(5):e00999. doi: 10.1002/prp2.999. [PMID: 36029006]
Abbas Jafari, Zeinab Esmaeilzadeh, Mohhamad Rafi Khezri, Hojat Ghasemnejad-Berenji, Sarvin Pashapour, Sonia Sadeghpour, Morteza Ghasemnejad-Berenji. An overview of possible pivotal mechanisms of Genistein as a potential phytochemical against SARS-CoV-2 infection: A hypothesis. Journal of food biochemistry. 2022 10; 46(10):e14345. doi: 10.1111/jfbc.14345. [PMID: 35866873]
Nadzirah Zullkiflee, Hussein Taha, Anwar Usman. Propolis: Its Role and Efficacy in Human Health and Diseases. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27186120. [PMID: 36144852]
Shu-Er Yang, Jin-Cherng Lien, Chia-Wen Tsai, Chi-Rei Wu. Therapeutic Potential and Mechanisms of Novel Simple O-Substituted Isoflavones against Cerebral Ischemia Reperfusion. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810394. [PMID: 36142301]
Pengshou Li, Mengdan Li, Xinhua Lou, Baosheng Zhao, Qixiang Ma, Yumiao Bian, Xiliang Mi. Evaluation of Hypoglycemic Activity and Sub-Acute Toxicity of the Novel Biochanin A-Chromium(III) Complex. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27185786. [PMID: 36144522]
Suet Cheung, Wan Fang, Xiao-Qing Li, Rui Wang, Shi-Kai Yan, Hui-Zi Jin. [A new isoflavone from Dalbergia odorifera and inhibitory activity of its tyrosinase]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(18):4959-4965. doi: 10.19540/j.cnki.cjcmm.20220422.202. [PMID: 36164905]
Sumbal Rasheed, Kanwal Rehman, Momina Shahid, Shaleem Suhail, Muhammad Sajid Hamid Akash. Therapeutic potentials of genistein: New insights and perspectives. Journal of food biochemistry. 2022 09; 46(9):e14228. doi: 10.1111/jfbc.14228. [PMID: 35579327]
Yu-Tong Xie, Shu-Hong Xiong, Yuan Bian, Yu Wang, Ruo-Qing Guan, Xin-Yuan Suo, Meng-Ran DU, Yan-Ping Liu, Yan-Hui Fu. [Chemical constituents from Artocarpus incisus and their inhibitory effects on proliferation of synoviocytes in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4665-4673. doi: 10.19540/j.cnki.cjcmm.20220506.203. [PMID: 36164873]
Ngoc Tung Quach, Thi Hanh Nguyen Vu, Thi Lien Bui, Anh Tuan Pham, Thi Thu An Nguyen, Thi Thanh Xuan Le, Thi Thu Thuy Ta, Pravin Dudhagara, Quyet-Tien Phi. Genome-Guided Investigation Provides New Insights into Secondary Metabolites of Streptomyces parvulus SX6 from Aegiceras corniculatum. Polish journal of microbiology. 2022 Sep; 71(3):381-394. doi: 10.33073/pjm-2022-034. [PMID: 36185028]
Atefeh Amerizadeh, Sedigheh Asgary, Golnaz Vaseghi, Ziba Farajzadegan. Effect of Genistein Intake on Some Cardiovascular Risk Factors: An Updated Systematic Review and Meta-analysis. Current problems in cardiology. 2022 Sep; 47(9):100902. doi: 10.1016/j.cpcardiol.2021.100902. [PMID: 34266697]
Monica Butnariu, Cristina Quispe, Javad Sharifi-Rad, Eduardo Pons-Fuster, Pia Lopez-Jornet, Wissam Zam, Tuyelee Das, Abhijit Dey, Manoj Kumar, Marius Pentea, Ali H Eid, Almagul Umbetova, Jen-Tsung Chen. Naturally-Occurring Bioactives in Oral Cancer: Preclinical and Clinical Studies, Bottlenecks and Future Directions. Frontiers in bioscience (Scholar edition). 2022 08; 14(3):24. doi: 10.31083/j.fbs1403024. [PMID: 36137983]
Qian Li, Ying Yang, Huihui Wang, Zhihao Jiang, Haitian Ma. Genistein accelerates glucose catabolism via activation the GPER-mediated cAMP/PKA-AMPK signaling pathway in broiler chickens. Life sciences. 2022 Aug; 303(?):120676. doi: 10.1016/j.lfs.2022.120676. [PMID: 35640778]
Nadja Kampschulte, Tim Berking, Ibrahim E Çelik, Stefan F Kirsch, Nils Helge Schebb. Inhibition of cytochrome P450 monooxygenase-catalyzed oxylipin formation by flavonoids: Evaluation of structure-activity relationship towards CYP4F2-selective inhibitors. European journal of medicinal chemistry. 2022 Aug; 238(?):114332. doi: 10.1016/j.ejmech.2022.114332. [PMID: 35576701]
Bret Cooper, Kimberly B Campbell, Wesley M Garrett. Salicylic Acid and Phytoalexin Induction by a Bacterium that Causes Halo Blight in Beans. Phytopathology. 2022 Aug; 112(8):1766-1775. doi: 10.1094/phyto-12-21-0496-r. [PMID: 35147446]
Yun-Jiao Zhang, Yi-Bo Pang, Xin-Yi Wang, Yong-Hui Jiang, Daniela D Herrera-Balandrano, Yan Jin, Su-Yan Wang, Pedro Laborda. Exogenous genistein enhances soybean resistance to Xanthomonas axonopodis pv. glycines. Pest management science. 2022 Aug; 78(8):3664-3675. doi: 10.1002/ps.7009. [PMID: 35611815]
Fernanda Dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri Dos Santos, Régis Mateus Hözer, Christianne Gazzana Salbego, Vera Maria Treis Trindade. Genistein prevents the decrease in ganglioside levels induced by amyloid-beta in the frontal cortex of rats. Neurological research. 2022 Jul; 44(7):598-604. doi: 10.1080/01616412.2021.2024731. [PMID: 35060438]
Songlin Zhou, Junqing Huang, Ke Li, Shuaigang DU, Bin Yang, Zhonghua Guo. Genistein attenuates LPS-induced inflammatory injury of rat dorsal root ganglion neuron via down-regulating HDAC6. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2022 Jun; 47(6):707-716. doi: 10.11817/j.issn.1672-7347.2022.210428. [PMID: 35837770]
Rumaisa Rashid, Anamika Kumari, Naibedya Chattopadhyay, Rajesh Jha, Singh Rajender. Genistein lowers fertility with pronounced effect in males: Meta-analyses on pre-clinical studies. Andrologia. 2022 Jun; ?(?):e14511. doi: 10.1111/and.14511. [PMID: 35760341]
Muntjeeb M Syed, Pooja J Doshi, Ankita Bharshankh, Dilip D Dhavale, Sudam L Kate, Girish Kulkarni, Jignesh B Doshi, Mohan V Kulkarni. Repurposing of genistein as anti-sickling agent: elucidation by multi spectroscopic, thermophoresis, and molecular modeling techniques. Journal of biomolecular structure & dynamics. 2022 06; 40(9):4038-4050. doi: 10.1080/07391102.2020.1852967. [PMID: 33305701]
Chetan Ram, Shobhit Gairola, Abu Mohammad Syed, Uttam Kulhari, Sourav Kundu, Madhav Nilakanth Mugale, Upadhyayula Suryanarayana Murty, Bidya Dhar Sahu. Biochanin A alleviates unilateral ureteral obstruction-induced renal interstitial fibrosis and inflammation by inhibiting the TGF-β1/Smad2/3 and NF-kB/NLRP3 signaling axis in mice. Life sciences. 2022 Jun; 298(?):120527. doi: 10.1016/j.lfs.2022.120527. [PMID: 35378138]
Francesca Giampieri, Justyna Godos, Giuseppe Caruso, Marcin Owczarek, Joanna Jurek, Sabrina Castellano, Raffaele Ferri, Filippo Caraci, Giuseppe Grosso. Dietary Phytoestrogen Intake and Cognitive Status in Southern Italian Older Adults. Biomolecules. 2022 05; 12(6):. doi: 10.3390/biom12060760. [PMID: 35740885]
Xue Liu, Lingling Li, Guang-Rong Zhao. Systems Metabolic Engineering of Escherichia coli Coculture for De Novo Production of Genistein. ACS synthetic biology. 2022 05; 11(5):1746-1757. doi: 10.1021/acssynbio.1c00590. [PMID: 35507680]
Reji Manjunathan, Vijayalakshmi Periyaswami, Kartik Mitra, Arokiaraj Sherlin Rosita, Medha Pandya, Jayaraman Selvaraj, Lokesh Ravi, Nalini Devarajan, Mukesh Doble. Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein. BMC bioinformatics. 2022 May; 23(1):180. doi: 10.1186/s12859-022-04724-9. [PMID: 35578172]
Everton Geraldo Capote Ferreira, Douglas Fabiano Gomes, Caroline Vanzzo Delai, Marco Antônio Bacellar Barreiros, Luciana Grange, Elisete Pains Rodrigues, Liliane Marcia Mertz Henning, Fernando Gomes Barcellos, Mariangela Hungria. Revealing potential functions of hypothetical proteins induced by genistein in the symbiosis island of Bradyrhizobium japonicum commercial strain SEMIA 5079 (= CPAC 15). BMC microbiology. 2022 05; 22(1):122. doi: 10.1186/s12866-022-02527-9. [PMID: 35513812]
X Yu, Y Q Zou, Y Wang, Z K Chen, D F Ma. [Equol and its enantiomers inhibited urethane-induced lung cancer in mice]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 2022 Apr; 54(2):244-248. doi: . [PMID: 35435186]
Mailin Gan, Xinquan Chen, Zongjian Chen, Lei Chen, Shunhua Zhang, Ye Zhao, Lili Niu, Xuewei Li, Linyuan Shen, Li Zhu. Genistein Alleviates High-Fat Diet-Induced Obesity by Inhibiting the Process of Gluconeogenesis in Mice. Nutrients. 2022 Apr; 14(8):. doi: 10.3390/nu14081551. [PMID: 35458112]
Mohammed Elmowafy, Khaled Shalaby, Mohammed Elkomy, Nabil K Alruwaili, Ehab M Mostafa, Muhammad Afzal, Khalid S Alharbi, Elshaer F Mohammed, Hazim M Ali, Ayman Salama, Elsaied H Barakat. Impact of highly phospholipid-containing lipid nanocarriers on oral bioavailability and pharmacodynamics performance of genistein. Pharmaceutical development and technology. 2022 Apr; 27(4):435-447. doi: 10.1080/10837450.2022.2076111. [PMID: 35531946]
Alexandre Lee, Souad Bensaada, Valérie Lamothe, Melissa Lacoste, Catherine Bennetau-Pelissero. Endocrine disruptors on and in fruits and vegetables: Estimation of the potential exposure of the French population. Food chemistry. 2022 Mar; 373(Pt B):131513. doi: 10.1016/j.foodchem.2021.131513. [PMID: 34776310]
Risako Fujikawa, Jun Yamada, Kyoko M Iinuma, Shozo Jinno. Phytoestrogen genistein modulates neuron-microglia signaling in a mouse model of chronic social defeat stress. Neuropharmacology. 2022 03; 206(?):108941. doi: 10.1016/j.neuropharm.2021.108941. [PMID: 34990615]
Martin J J Ronis, Horacio Gomez-Acevedo, Kartik Shankar, Leah Hennings, Neha Sharma, Michael L Blackburn, Isabelle Miousse, Harry Dawson, Celine Chen, Kelly E Mercer, Thomas M Badger. Soy Formula Is Not Estrogenic and Does Not Result in Reproductive Toxicity in Male Piglets: Results from a Controlled Feeding Study. Nutrients. 2022 Mar; 14(5):. doi: 10.3390/nu14051126. [PMID: 35268101]
Manisha J Oza, Yogesh A Kulkarni. Biochanin A Attenuates Cardiomyopathy in Type 2 Diabetic Rats by Increasing SIRT1 Expression and Reducing Oxidative Stress. Chemistry & biodiversity. 2022 Mar; 19(3):e202100591. doi: 10.1002/cbdv.202100591. [PMID: 35119190]
Mohamed Mahmoud, Maha R A Abdollah, Mohamed E Elsesy, Dalal A Abou El Ella, Suher K Zada, Mai F Tolba. The natural isoflavone Biochanin-A synergizes 5-fluorouracil anticancer activity in vitro and in vivo in Ehrlich solid-phase carcinoma model. Phytotherapy research : PTR. 2022 Mar; 36(3):1310-1325. doi: 10.1002/ptr.7388. [PMID: 35112408]
Anuson Poasakate, Putcharawipa Maneesai, Prapassorn Potue, Sarawoot Bunbupha, Terdthai Tong-Un, Wannapa Settheetham-Ishida, Juthamas Khamseekaew, Poungrat Pakdeechote. Genistein alleviates renin-angiotensin system mediated vascular and kidney alterations in renovascular hypertensive rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Feb; 146(?):112601. doi: 10.1016/j.biopha.2021.112601. [PMID: 35062067]
Hai-Yan Duan, Jian Wang, Liang-Ping Zha, Hua-Sheng Peng, Yu-Ping Zhao, Yuan Yuan, Lu-Qi Huang. Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii. Chinese journal of natural medicines. 2022 Feb; 20(2):133-138. doi: 10.1016/s1875-5364(21)60105-x. [PMID: 35279240]
Jinyue Liu, Wenbo Jiang. Identification and characterization of unique 5-hydroxyisoflavonoid biosynthetic key enzyme genes in Lupinus albus. Plant cell reports. 2022 Feb; 41(2):415-430. doi: 10.1007/s00299-021-02818-x. [PMID: 34851457]
Xing Ma, Xiaowei Yu, Jialing Min, Xin Chen, Ren Liu, Xueqing Cui, Jing Cheng, Mingyong Xie, Patrick Diel, Xiaojuan Hu. Genistein interferes with antitumor effects of cisplatin in an ovariectomized breast cancer xenograft tumor model. Toxicology letters. 2022 Feb; 355(?):106-115. doi: 10.1016/j.toxlet.2021.11.013. [PMID: 34838996]
Kailin Yang, Junpeng Chen, Tianqing Zhang, Xiao Yuan, Anqi Ge, Shanshan Wang, Hao Xu, Liuting Zeng, Jinwen Ge. Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis. Frontiers in immunology. 2022; 13(?):949746. doi: 10.3389/fimmu.2022.949746. [PMID: 36159792]
Alisa A Suen, Anna C Kenan, Carmen J Williams. Developmental exposure to phytoestrogens found in soy: New findings and clinical implications. Biochemical pharmacology. 2022 01; 195(?):114848. doi: 10.1016/j.bcp.2021.114848. [PMID: 34801523]
Kohji Yamamoto, Naotaka Yamada, Satoshi Endo, Katsuhisa Kurogi, Yoichi Sakakibara, Masahito Suiko. Novel silkworm (Bombyx mori) sulfotransferase swSULT ST3 is involved in metabolism of polyphenols from mulberry leaves. PloS one. 2022; 17(8):e0270804. doi: 10.1371/journal.pone.0270804. [PMID: 35925958]
Alice W Lee, Valerie Poynor, Archana J McEligot. Urinary Phytoestrogen Levels Are Associated with Female Hormonal Cancers: An Analysis of NHANES Data From 1999 to 2010. Nutrition and cancer. 2022; 74(8):2748-2756. doi: 10.1080/01635581.2021.2020304. [PMID: 35014926]
Jasmina Živanović, Ivana Jarić, Vladimir Ajdžanović, Marko Miler, Sanja Stanković, Verica Milošević, Branko Filipović. Genistein regulates calcium and phosphate homeostasis without activation of MEK 1/2 signalling pathway in an animal model of the andropause. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2022 Jan; 239(?):151836. doi: 10.1016/j.aanat.2021.151836. [PMID: 34563672]
Ying Xu, Dingqi Zhang, Hailin Yang, Yu Liu, Linzhang Zhang, Congcong Zhang, Gaofeng Chen, Yonghong Hu, Jiamei Chen, Hua Zhang, Yongping Mu, Ping Liu, Wei Liu. Hepatoprotective effect of genistein against dimethylnitrosamine-induced liver fibrosis in rats by regulating macrophage functional properties and inhibiting the JAK2/STAT3/SOCS3 signaling pathway. Frontiers in bioscience (Landmark edition). 2021 12; 26(12):1572-1584. doi: 10.52586/5050. [PMID: 34994171]
Aboli Girme, Prajkta Bhoj, Ganesh Saste, Sandeep Pawar, Amit Mirgal, Dipak Raut, Machindra Chavan, Lal Hingorani. Development and Validation of RP-HPLC Method for Vicenin-2, Orientin, Cynaroside, Betulinic Acid, Genistein, and Major Eight Bioactive Constituents with LC-ESI-MS/MS Profiling in Ocimum Genus. Journal of AOAC International. 2021 Dec; 104(6):1634-1651. doi: 10.1093/jaoacint/qsab067. [PMID: 33930142]
Evangelia Bampali, Stefan Germer, Rudolf Bauer, Žarko Kulić. HPLC-UV/HRMS methods for the unambiguous detection of adulterations of Ginkgo biloba leaves with Sophora japonica fruits on an extract level. Pharmaceutical biology. 2021 Dec; 59(1):438-443. doi: 10.1080/13880209.2021.1910717. [PMID: 33886418]
Jordi P D Kleinloog, Lea Tischmann, Ronald P Mensink, Tanja C Adam, Peter J Joris. Longer-term soy nut consumption improves cerebral blood flow and psychomotor speed: results of a randomized, controlled crossover trial in older men and women. The American journal of clinical nutrition. 2021 12; 114(6):2097-2106. doi: 10.1093/ajcn/nqab289. [PMID: 34510189]