Orientin (BioDeep_00000399401)

Main id: BioDeep_00000000384

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one

化学式: C21H20O11 (448.1006)
中文名称: 荭草苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O)=C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C2OC(C3C=CC(O)=C(O)C=3)=CC(=O)C=2C(O)=C1
InChI: InChI=1S/C21H20O11/c22-6-14-17(28)18(29)19(30)21(32-14)16-11(26)4-10(25)15-12(27)5-13(31-20(15)16)7-1-2-8(23)9(24)3-7/h1-5,14,17-19,21-26,28-30H,6H2/t14-,17-,18+,19-,21+/m1/s1

描述信息

Orientin is a C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8. It has a role as an antioxidant and a metabolite. It is a C-glycosyl compound, a tetrahydroxyflavone and a 3-hydroxyflavonoid. It is functionally related to a luteolin.
Orientin is a natural product found in Itea chinensis, Vellozia epidendroides, and other organisms with data available.
See also: Cannabis sativa subsp. indica top (part of); Fenugreek seed (part of); Acai fruit pulp (part of).
A C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8.
Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. Orientin is a promising neuroprotective agent suitable for therapy for neuropathic pain[1][2].
Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. Orientin is a promising neuroprotective agent suitable for therapy for neuropathic pain[1][2].

同义名列表

47 个代谢物同义名

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]chromen-4-one; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4H-chromen-4-one; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; D-GLUCITOL, 1,5-ANHYDRO-1-C-(2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4-OXO-4H-1-BENZOPYRAN-8-YL)-, (1S)-; (1S)-1,5-ANHYDRO-1-(2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4-OXO-4H-CHROMEN-8-YL)-D-GLUCITOL; 2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-8-(.BETA.-D-GLUCOPYRANOSYL)-4H-1-BENZOPYRAN-4-ONE; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-.beta.-D-glucopyranosyl-5,7-dihydroxy-; 8-(.BETA.-D-GLUCOPYRANOSYL)-2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4H-1-BENZOPYRAN-4-ONE; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-dihydroxy-; 2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-8-(beta-D-GLUCOPYRANOSYL)-4H-1-BENZOPYRAN-4-ONE; 8-(beta-D-GLUCOPYRANOSYL)-2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4H-1-BENZOPYRAN-4-ONE; 2-(3,4-DIHYDROXYPHENYL)-8-.BETA.-D-GLUCOPYRANOSYL-5,7-DIHYDROXY-4H-1-BENZOPYRAN-4-ONE; 4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-dihydroxy; 2-(3,4-Dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one; 2-(3,4-DIHYDROXYPHENYL)-8-.BETA.-D-GLUCOPYRANOSYL-5,7-DIHYDROXY-4H-CHROMEN-4-ONE; 2-(3,4-dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-dihydroxy-4H-chromen-4-one; 8-C-beta-glucopyranosyl-3,4,5,7-tetrahydroxyflav-2-en-3-one; 8-.beta.-D-Glucopyranosyl-3,4,5,7-tetrahydroxyflavone; 8-beta-D-Glucopyranosyl-3,4,5,7-tetrahydroxyflavone; Orientin, primary pharmaceutical reference standard; 8-b-D-Glucopyranosyl-3,4,7-tetrahydroxyflavone; LUTEOLIN 8-C-.BETA.-D-GLUCOPYRANOSIDE; LUTEOLIN 8-C-.BETA.-GLUCOPYRANOSIDE; luteolin 8-C-beta-D-glucopyranoside; LUTEOLIN 8-C-beta-GLUCOPYRANOSIDE; Luteolin 8-C-b-D-glucopyranoside; Orientin, analytical standard; PLAPMLGJVGLZOV-VPRICQMDSA-N; 8-.BETA.-D-GLUCOSYLLUTEOLIN; 8-beta-D-glucosylluteolin; Orientin, >=97\\% (HPLC); luteolin-8-c-glucoside; Luteolin 8-C-glucoside; Luteolin 8-glucoside; Luteolin-8-glucoside; 8C-hexosyl luteolin; 8-glucosylluteolin; Orientin (Flavone); UNII-IAX93XCW6C; IAX93XCW6C; orientine; Orientin; J17.734B; Lutexin; USE; Orientin



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

639 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, AXIN2, BCL2, CA1, CASP3, CAT, EP300, MAPK8, PIK3CA, PRKAA2, PTGS2, SLC6A3
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 4 BCL2, HMOX1, PTGS2, RTN4
Nucleus 9 AKT1, AXIN2, BCL2, CASP3, EP300, GABPA, HMOX1, MAPK8, PRKAA2
cytosol 12 AKT1, AXIN2, BCL2, CA1, CASP3, CAT, COMT, EP300, HMOX1, MAPK8, PIK3CA, PRKAA2
dendrite 2 COMT, PRKAA2
centrosome 1 AXIN2
nucleoplasm 7 AKT1, CASP3, EP300, GABPA, HMOX1, MAPK8, PRKAA2
Cell membrane 5 AKT1, COMT, RTN4, SLC6A3, TNF
Cytoplasmic side 2 HMOX1, RTN4
lamellipodium 2 AKT1, PIK3CA
Cell projection, axon 1 SLC6A3
Multi-pass membrane protein 2 RTN4, SLC6A3
Synapse 3 COMT, MAPK8, RTN4
cell cortex 1 AKT1
cell junction 1 RTN4
cell surface 2 SLC6A3, TNF
glutamatergic synapse 3 AKT1, CASP3, RTN4
Golgi apparatus 2 ATRN, PRKAA2
Golgi membrane 1 INS
neuronal cell body 5 CASP3, PRKAA2, RTN4, SLC6A3, TNF
postsynapse 1 AKT1
presynaptic membrane 1 SLC6A3
plasma membrane 8 AKT1, ATRN, AXIN2, COMT, PIK3CA, RTN4, SLC6A3, TNF
Membrane 7 AKT1, BCL2, CAT, COMT, HMOX1, PRKAA2, SLC6A3
axon 4 COMT, MAPK8, PRKAA2, SLC6A3
caveola 1 PTGS2
extracellular exosome 4 ATRN, CA1, CAT, COMT
endoplasmic reticulum 4 BCL2, HMOX1, PTGS2, RTN4
extracellular space 5 ATRN, HMOX1, IL6, INS, TNF
perinuclear region of cytoplasm 2 HMOX1, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, CAT
protein-containing complex 4 AKT1, BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 2 CAT, COMT
Microsome membrane 1 PTGS2
postsynaptic density 2 CASP3, RTN4
Single-pass type I membrane protein 1 ATRN
Secreted 2 IL6, INS
extracellular region 4 CAT, IL6, INS, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
neuronal cell body membrane 1 SLC6A3
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 1 CAT
Extracellular side 2 COMT, RTN4
anchoring junction 1 RTN4
transcription regulator complex 1 EP300
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 2 COMT, TNF
vesicle 1 AKT1
postsynaptic membrane 1 SLC6A3
Membrane raft 2 SLC6A3, TNF
pore complex 1 BCL2
focal adhesion 1 CAT
spindle 1 AKT1
flotillin complex 1 SLC6A3
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 1 PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, neuron projection 1 SLC6A3
neuron projection 3 PTGS2, RTN4, SLC6A3
ciliary basal body 1 AKT1
chromatin 2 EP300, GABPA
phagocytic cup 1 TNF
Chromosome 1 EP300
[Isoform 3]: Secreted 1 ATRN
nuclear envelope 1 RTN4
endosome lumen 1 INS
cytoplasmic stress granule 1 PRKAA2
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
axon terminus 1 SLC6A3
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
histone acetyltransferase complex 1 EP300
protein-DNA complex 1 EP300
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 ATRN
dopaminergic synapse 1 SLC6A3
nucleotide-activated protein kinase complex 1 PRKAA2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
endoplasmic reticulum tubular network 1 RTN4
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
endoplasmic reticulum tubular network membrane 1 RTN4
[Isoform a]: Endoplasmic reticulum membrane 1 RTN4
[Isoform b]: Endoplasmic reticulum membrane 1 RTN4
[Isoform C]: Endoplasmic reticulum membrane 1 RTN4


文献列表

  • Lucia Camelia Pirvu, Lucia Pintilie, Adrian Albulescu, Amalia Stefaniu, Georgeta Neagu. Anti-Proliferative Potential of Cynaroside and Orientin-In Silico (DYRK2) and In Vitro (U87 and Caco-2) Studies. International journal of molecular sciences. 2023 Nov; 24(23):. doi: 10.3390/ijms242316555. [PMID: 38068880]
  • Jia-Yi Tao, Jing Li, Lu Wan, Bi-Zhen Dong, Yong-Jie Yu, Ye-Mao Liu, Mao-Lin Yi, Li-Peng Wan. Orientin regulates the proliferation and migration of hepatocellular carcinoma cells. Naunyn-Schmiedeberg's archives of pharmacology. 2023 May; ?(?):. doi: 10.1007/s00210-023-02472-y. [PMID: 37178274]
  • Dong-Dong Guo, Hai-Yan Huang, Hai-E Liu, Kun Liu, Xing-Jing Luo. Orientin Reduces the Effects of Repeated Procedural Neonatal Pain in Adulthood: Network Pharmacology Analysis, Molecular Docking Analysis, and Experimental Validation. Pain research & management. 2023; 2023(?):8893932. doi: 10.1155/2023/8893932. [PMID: 38047157]
  • Qingfei Xiao, Ying Zhao, Lei Ma, Rongli Piao. Orientin reverses acetaminophen-induced acute liver failure by inhibiting oxidative stress and mitochondrial dysfunction. Journal of pharmacological sciences. 2022 May; 149(1):11-19. doi: 10.1016/j.jphs.2022.01.012. [PMID: 35369900]
  • Weiqin Ji, Wei Xu. Orientin inhibits the progression of fibroblast-like synovial cells in rheumatoid arthritis by regulating MAPK-signaling pathway. Allergologia et immunopathologia. 2022; 50(6):154-162. doi: 10.15586/aei.v50i6.742. [PMID: 36335459]
  • Yuan Qu, Lin Shi, Yu Liu, Lv Huang, Huai-Rong Luo, Gui-Sheng Wu. Orientin Prolongs the Longevity of Caenorhabditis elegans and Postpones the Development of Neurodegenerative Diseases via Nutrition Sensing and Cellular Protective Pathways. Oxidative medicine and cellular longevity. 2022; 2022(?):8878923. doi: 10.1155/2022/8878923. [PMID: 35237385]
  • Aboli Girme, Prajkta Bhoj, Ganesh Saste, Sandeep Pawar, Amit Mirgal, Dipak Raut, Machindra Chavan, Lal Hingorani. Development and Validation of RP-HPLC Method for Vicenin-2, Orientin, Cynaroside, Betulinic Acid, Genistein, and Major Eight Bioactive Constituents with LC-ESI-MS/MS Profiling in Ocimum Genus. Journal of AOAC International. 2021 Dec; 104(6):1634-1651. doi: 10.1093/jaoacint/qsab067. [PMID: 33930142]
  • Sithandiwe E Mazibuko-Mbeje, Sinenhlanhla X H Mthembu, Andani Tshiitamune, Ndivhuwo Muvhulawa, Fikile T Mthiyane, Khanyisani Ziqubu, Christo J F Muller, Phiwayinkosi V Dludla. Orientin Improves Substrate Utilization and the Expression of Major Genes Involved in Insulin Signaling and Energy Regulation in Cultured Insulin-Resistant Liver Cells. Molecules (Basel, Switzerland). 2021 Oct; 26(20):. doi: 10.3390/molecules26206154. [PMID: 34684734]
  • Clara Azalea Berenguer-Rivas, Julio César Escalona-Arranz, Gabriel Llauradó-Maury, Anastasia Van der Auwera, Stefano Piazza, Daniel Méndez-Rodríguez, Kenn Foubert, Paul Cos, Luc Pieters. Anti-inflammatory effect of Adelia ricinella L. aerial parts. The Journal of pharmacy and pharmacology. 2021 Mar; 73(4):553-559. doi: 10.1093/jpp/rgaa057. [PMID: 33793832]
  • Md Nurul Huda, Shuai Lu, Tanzim Jahan, Mengqi Ding, Rintu Jha, Kaixuan Zhang, Wei Zhang, Milen I Georgiev, Sang Un Park, Meiliang Zhou. Treasure from garden: Bioactive compounds of buckwheat. Food chemistry. 2021 Jan; 335(?):127653. doi: 10.1016/j.foodchem.2020.127653. [PMID: 32739818]
  • Mariane B Chagas, Daniel O B Pontes, Allan V D Albino, Emanuel J Ferreira, Jovelina S F Alves, Anallicy S Paiva, Daniel L Pontes, Silvana M Z Langansser, Leandro S Ferreira. Bioinspired oxidation in cytochrome P450 of isomers orientin and isoorientin using Salen complexes. Rapid communications in mass spectrometry : RCM. 2020 Sep; 34 Suppl 3(?):e8757. doi: 10.1002/rcm.8757. [PMID: 32061191]
  • Tiejun Chen, Meizi Piao, Syed Md Ehsanur Rahman, Lehong Zhang, Yang Deng. Influence of fermentation on antioxidant and hypolipidemic properties of maifanite mineral water-cultured common buckwheat sprouts. Food chemistry. 2020 Aug; 321(?):126741. doi: 10.1016/j.foodchem.2020.126741. [PMID: 32276146]
  • Eui Jeong Nam, Gyhye Yoo, Joo Young Lee, Myungsuk Kim, Changho Jhin, Yang-Ju Son, Sun Young Kim, Sang Hoon Jung, Chu Won Nho. Glycosyl flavones from Humulus japonicus suppress MMP-1 production via decreasing oxidative stress in UVB irradiated human dermal fibroblasts. BMB reports. 2020 Jul; 53(7):379-384. doi: . [PMID: 32317077]
  • Amsha Viraragavan, Nokulunga Hlengwa, Dalene de Beer, Sylvia Riedel, Neil Miller, Sandra Bowles, Beata Walczak, Christo Muller, Elizabeth Joubert. Model development for predicting in vitro bio-capacity of green rooibos extract based on composition for application as screening tool in quality control. Food & function. 2020 Apr; 11(4):3084-3094. doi: 10.1039/c9fo02480h. [PMID: 32195502]
  • Chunmeng Li, Chanchun Cai, Xiangjian Zheng, Jun Sun, Liou Ye. Orientin suppresses oxidized low-density lipoproteins induced inflammation and oxidative stress of macrophages in atherosclerosis. Bioscience, biotechnology, and biochemistry. 2020 Apr; 84(4):774-779. doi: 10.1080/09168451.2019.1702871. [PMID: 31829093]
  • Luciana Arantes Dantas, Márcio Rosa, Erika Crispim Resende, Fabiano Guimarães Silva, Paulo Sérgio Pereira, Ana Cristina Lourenço Souza, Fernando Higino de Lima E Silva, Aurélio Rubio Neto. Spectral quality as an elicitor of bioactive compound production in Solanum aculeatissimum JACQ cell suspension. Journal of photochemistry and photobiology. B, Biology. 2020 Mar; 204(?):111819. doi: 10.1016/j.jphotobiol.2020.111819. [PMID: 32062388]
  • Eun Mi Choi, Kwang Sik Suh, So Young Park, Soojin Yun, Sang Ouk Chin, Sang Youl Rhee, Suk Chon. Orientin reduces the inhibitory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin signaling pathway in murine 3T3-L1 adipocytes. Chemico-biological interactions. 2020 Feb; 318(?):108978. doi: 10.1016/j.cbi.2020.108978. [PMID: 32044341]
  • Francisco Oiram Filho, Ebenézer de Oliveira Silva, Mônica Maria de Almeida Lopes, Paulo Riceli Vasconselos Ribeiro, Andréia Hansen Oster, Jhonyson Arruda Carvalho Guedes, Dávila de Souza Zampieri, Patrícia do Nascimento Bordallo, Guilherme Julião Zocolo. Effect of pulsed light on postharvest disease control-related metabolomic variation in melon (Cucumis melo) artificially inoculated with Fusarium pallidoroseum. PloS one. 2020; 15(4):e0220097. doi: 10.1371/journal.pone.0220097. [PMID: 32310943]
  • Fenghao Tian, Ming Tong, Zizhi Li, Weichao Huang, Yanyang Jin, Qingfei Cao, Xiaoli Zhou, Guangquan Tong. The Effects of Orientin on Proliferation and Apoptosis of T24 Human Bladder Carcinoma Cells Occurs Through the Inhibition of Nuclear Factor-kappaB and the Hedgehog Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2019 Dec; 25(?):9547-9554. doi: 10.12659/msm.919203. [PMID: 31837261]
  • Aleksandra Maria Juszczak, Marijana Zovko-Končić, Michał Tomczyk. Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives. Biomolecules. 2019 11; 9(11):. doi: 10.3390/biom9110731. [PMID: 31726801]
  • Michael McCullagh, Cintia Alessandra Matiucci Pereira, Janete Harumi Yariwake. Use of ion mobility mass spectrometry to enhance cumulative analytical specificity and separation to profile 6-C/8-C-glycosylflavone critical isomer pairs and known-unknowns in medicinal plants. Phytochemical analysis : PCA. 2019 Jul; 30(4):424-436. doi: 10.1002/pca.2825. [PMID: 30891865]
  • Akeem O Lawal, Lester M Davids, Jeanine L Marnewick. Rooibos (Aspalathus linearis) and honeybush (Cyclopia species) modulate the oxidative stress associated injury of diesel exhaust particles in human umbilical vein endothelial cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jun; 59(?):152898. doi: 10.1016/j.phymed.2019.152898. [PMID: 30986715]
  • Shiqi Zheng, Di Geng, Shuangyue Liu, Qingqing Wang, Siqi Liu, Rufeng Wang. A newly isolated human intestinal bacterium strain capable of deglycosylating flavone C-glycosides and its functional properties. Microbial cell factories. 2019 May; 18(1):94. doi: 10.1186/s12934-019-1144-7. [PMID: 31138294]
  • Kalaiyarasu Thangaraj, Karthi Natesan, Kandakumar Settu, Mariyappan Palani, Mydhili Govindarasu, Vanitha Subborayan, Manju Vaiyapuri. Orientin mitigates 1, 2-dimethylhydrazine induced lipid peroxidation, antioxidant and biotransforming bacterial enzyme alterations in experimental rats. Journal of cancer research and therapeutics. 2018 Oct; 14(6):1379-1388. doi: 10.4103/jcrt.jcrt_1363_16. [PMID: 30488860]
  • Li-Jia Liu, Xiu-Hua Hu, Li-Na Guo, Ru-Feng Wang, Qi-Tao Zhao. Anti-inflammatory effect of the compounds from the flowers of Trollius chinensis. Pakistan journal of pharmaceutical sciences. 2018 Sep; 31(5):1951-1957. doi: ". [PMID: 30150194]
  • Dongdong Guo, Xinyi Hu, Haojie Zhang, Chenghua Lu, Guangwei Cui, Xingjing Luo. Orientin and neuropathic pain in rats with spinal nerve ligation. International immunopharmacology. 2018 May; 58(?):72-79. doi: 10.1016/j.intimp.2018.03.013. [PMID: 29558662]
  • Nan Zhao, Qi Sun, Yang Song, Lin Wang, Tingjian Zhang, Fanhao Meng. Comparative pharmacokinetics study of orientin in rat plasma by UHPLC-MS/MS after intravenous administration of single orientin and Trollius chinensis Bunge extract. Biomedical chromatography : BMC. 2018 Apr; 32(4):. doi: 10.1002/bmc.4142. [PMID: 29148582]
  • Izabel Lucena Gadioli, Marcela de Sá Barreto da Cunha, Mariana Veras Oliveira de Carvalho, Ana Maria Costa, Lívia de Lacerda de Oliveira Pineli. A systematic review on phenolic compounds in Passiflora plants: Exploring biodiversity for food, nutrition, and popular medicine. Critical reviews in food science and nutrition. 2018 Mar; 58(5):785-807. doi: 10.1080/10408398.2016.1224805. [PMID: 27645583]
  • Shiori Nagai, Chihiro Matsumoto, Makio Shibano, Ko Fujimori. Suppression of Fatty Acid and Triglyceride Synthesis by the Flavonoid Orientin through Decrease of C/EBPδ Expression and Inhibition of PI3K/Akt-FOXO1 Signaling in Adipocytes. Nutrients. 2018 Jan; 10(2):. doi: 10.3390/nu10020130. [PMID: 29373533]
  • Jiwon Baek, Dahae Lee, Tae Kyoung Lee, Ji Hoon Song, Ju Sung Lee, Seong Lee, Sang-Woo Yoo, Ki Sung Kang, Eunjung Moon, Sanghyun Lee, Ki Hyun Kim. (-)-9'-O-(α-l-Rhamnopyranosyl)lyoniresinol from Lespedeza cuneata suppresses ovarian cancer cell proliferation through induction of apoptosis. Bioorganic & medicinal chemistry letters. 2018 01; 28(2):122-128. doi: 10.1016/j.bmcl.2017.11.045. [PMID: 29223588]
  • Mengxia Wei, Lei Yang. Determination of orientin in Trollius chinensis using ultrasound-assisted extraction and high performance liquid chromatography: Several often-overlooked sample preparation parameters in an ultrasonic bath. Journal of chromatography. A. 2017 Dec; 1530(?):68-79. doi: 10.1016/j.chroma.2017.11.034. [PMID: 29153914]
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