Phlorizin (BioDeep_00000398016)

Main id: BioDeep_00000000068

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


1-[2,4-dihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]-3-(4-hydroxyphenyl)propan-1-one

化学式: C21H24O10 (436.1369)
中文名称: 根皮苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O)C=C(O)C(C(=O)CCC2C=CC(O)=CC=2)=C(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=1
InChI: InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2

描述信息

Origin: Plant; Formula(Parent): C21H24O10; Bottle Name:Phloridzin; PRIME Parent Name:Phloretin-2-O-glucoside; PRIME in-house No.:S0307, Glycosides
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.718
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.713
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.714
Acquisition and generation of the data is financially supported by the Max-Planck-Society
IPB_RECORD: 2021; CONFIDENCE confident structure
Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.

同义名列表

56 个代谢物同义名

1-[2,4-dihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]-3-(4-hydroxyphenyl)propan-1-one; 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-phenyl]-3-(4-hydroxyphenyl)propan-1-one; 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-phenyl]-3-(4-hydroxyphenyl)propan-1-one; 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phenyl]-3-(4-hydroxyphenyl)propan-1-one; 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one; 1-Propanone, 1-(2-(beta-D-glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-; 1-Propanone, 1-[2-(beta-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-; 1-[2-(.beta.-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone; 2-(.beta.-D-glucopyranosyloxy)-4,6-dihydroxy-3-(4-hydroxyphenyl)propiophenone; 2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxy-3-(4-hydroxyphenyl)propiophenone; 3,5-dihydroxy-2-[3-(4-hydroxyphenyl)propanoyl]phenyl beta-D-glucopyranoside; 4,6-dihydroxy-2-(beta-D-glucosido)-beta-(p-hydroxyphenyl)propiophenone; Phloretin-2-beta-glucoside; SDCCGMLS-0066626.P001; Phloretin 2-glucoside; Phlorhizin;Phlorizin; EINECS 200-487-1; Spectrum5_000521; Spectrum4_001651; Spectrum2_000701; Spectrum3_001227; Spectrum_001291; NCGC00142423-01; SpecPlus_000325; SPECTRUM300547; DivK1c_006421; BSPBio_002674; KBioGR_002141; KBioSS_001771; SPBio_000881; KBio3_002174; KBio2_001771; ZINC03875408; KBio2_006907; Phloridzosid; KBio1_001365; KBio2_004339; Phlorrhizen; AIDS-009884; 112318-65-7; 16055-86-0; Phloridzin; AIDS009884; 52276-56-9; CHEBI:8113; Phlorhizin; AI3-19835; SBB005924; Phlorizin; Floridzin; NSC 2833; 60-81-1; C01604; 4,2,4,6-Tetrahydroxydihydroxychalcone 2-glucoside; Phlr-2p-Glc; Phlorizin



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

151 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ANPEP, BCL2, CASP3, CAT, MTOR, POMC, SLC2A2, TYR
Peripheral membrane protein 2 ACHE, MTOR
Endoplasmic reticulum membrane 3 BCL2, HSP90B1, MTOR
Nucleus 5 ACHE, BCL2, CASP3, HSP90B1, MTOR
cytosol 6 BCL2, CASP3, CAT, HSP90B1, MTOR, SLC2A1
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 3 ATP2B1, CASP3, MTOR
Cell membrane 7 ACHE, ANPEP, ATP2B1, SLC2A1, SLC2A2, SLC5A2, TNF
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 5 ATP2B1, SLC2A1, SLC2A2, SLC5A1, SLC5A2
Golgi apparatus membrane 1 MTOR
Synapse 2 ACHE, ATP2B1
cell surface 2 ACHE, TNF
glutamatergic synapse 2 ATP2B1, CASP3
Golgi apparatus 2 ACHE, SI
Golgi membrane 3 INS, MTOR, SLC2A1
lysosomal membrane 2 ANPEP, MTOR
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
presynaptic membrane 1 ATP2B1
sarcolemma 1 SLC2A1
smooth endoplasmic reticulum 1 HSP90B1
Lysosome 2 MTOR, TYR
Presynapse 1 SLC2A1
plasma membrane 11 ACHE, ANPEP, ATP2B1, GCG, LCT, SI, SLC2A1, SLC2A2, SLC5A1, SLC5A2, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 10 ACHE, ATP2B1, BCL2, CAT, HSP90B1, MTOR, SI, SLC2A1, SLC2A2, SLC5A2
apical plasma membrane 5 SI, SLC2A1, SLC2A2, SLC5A1, SLC5A2
basolateral plasma membrane 2 ATP2B1, SLC2A1
brush border 2 SI, SLC2A2
caveola 1 SLC2A1
extracellular exosome 8 ANPEP, ATP2B1, CAT, HSP90B1, SI, SLC2A1, SLC5A1, SLC5A2
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 BCL2, HSP90B1
extracellular space 7 ACHE, ANPEP, GCG, IL6, INS, POMC, TNF
perinuclear region of cytoplasm 4 ACHE, HSP90B1, SLC5A1, TYR
intercalated disc 1 SLC2A1
mitochondrion 2 BCL2, CAT
protein-containing complex 3 BCL2, CAT, HSP90B1
intracellular membrane-bounded organelle 3 ATP2B1, CAT, TYR
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 LCT, TYR
Secreted 5 ACHE, GCG, IL6, INS, POMC
extracellular region 8 ACHE, CAT, GCG, HSP90B1, IL6, INS, POMC, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
photoreceptor inner segment 1 SLC2A1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANPEP, TNF
Z disc 1 SLC2A1
Melanosome membrane 1 TYR
midbody 2 HSP90B1, SLC2A1
Early endosome 1 SLC5A1
cell-cell junction 1 SLC2A2
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 2 ANPEP, TNF
Apical cell membrane 3 LCT, SLC5A1, SLC5A2
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 2 CAT, HSP90B1
Peroxisome 1 CAT
basement membrane 1 ACHE
intracellular vesicle 1 SLC5A1
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 POMC
lateral plasma membrane 1 ATP2B1
cell projection 1 ATP2B1
phagocytic cup 1 TNF
brush border membrane 1 SLC5A1
blood microparticle 1 SLC2A1
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
female germ cell nucleus 1 SLC2A1
Melanosome 3 HSP90B1, SLC2A1, TYR
Presynaptic cell membrane 1 ATP2B1
side of membrane 1 ACHE
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 4 CAT, GCG, INS, POMC
secretory granule membrane 1 ANPEP
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 GCG, HSP90B1, IL6, INS
cortical actin cytoskeleton 1 SLC2A1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
Sarcoplasmic reticulum lumen 1 HSP90B1
endoplasmic reticulum-Golgi intermediate compartment 1 ANPEP
synaptic cleft 1 ACHE
external side of apical plasma membrane 1 LCT
death-inducing signaling complex 1 CASP3
female pronucleus 1 SLC2A1
Cytoplasmic vesicle, phagosome 1 MTOR
endocytic vesicle lumen 1 HSP90B1
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSP90B1
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
glucose transporter complex 1 SLC2A1
intracellular organelle 1 SLC5A1
[Isoform H]: Cell membrane 1 ACHE
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Suping Zeng, Longhua Yu, Ping He, Hui Feng, Jia Wang, Huacong Zhang, Yunxia Song, Ren Liu, Yueqiao Li. Integrated transcriptome and metabolome analysis reveals the regulation of phlorizin synthesis in Lithocarpus polystachyus under nitrogen fertilization. BMC plant biology. 2024 May; 24(1):366. doi: 10.1186/s12870-024-05090-9. [PMID: 38711037]
  • Qian Zhao, Xiaoning Li, Yu Jiao, Ying Chen, Yanfang Yan, Yuzhu Wang, Cyril Hamiaux, Yule Wang, Fengwang Ma, Ross G Atkinson, Pengmin Li. Identification of two key genes involved in flavonoid catabolism and their different roles in apple resistance to biotic stresses. The New phytologist. 2024 May; 242(3):1238-1256. doi: 10.1111/nph.19644. [PMID: 38426393]
  • Chen-Mu Luo, Li-Fan Ke, Xiang-Yu Huang, Xiao-Yan Zhuang, Ze-Wang Guo, Qiong Xiao, Jun Chen, Fu-Quan Chen, Qiu-Ming Yang, Yi Ru, Hui-Fen Weng, An-Feng Xiao, Yong-Hui Zhang. Efficient biosynthesis of prunin in methanol cosolvent system by an organic solvent-tolerant α-L-rhamnosidase from Spirochaeta thermophila. Enzyme and microbial technology. 2024 Apr; 175(?):110410. doi: 10.1016/j.enzmictec.2024.110410. [PMID: 38340378]
  • Virgile Neyman, Maude Quicray, Frédéric Francis, Catherine Michaux. Toxicological, biochemical, and in silico investigations of three trehalase inhibitors for new ways to control aphids. Archives of insect biochemistry and physiology. 2024 Apr; 115(4):e22112. doi: 10.1002/arch.22112. [PMID: 38605672]
  • Xueran Mei, Yi Li, Xiaoyu Zhang, Xiwen Zhai, Yi Yang, Zhengjuan Li, Liping Li. Maternal Phlorizin Intake Protects Offspring from Maternal Obesity-Induced Metabolic Disorders in Mice via Targeting Gut Microbiota to Activate the SCFA-GPR43 Pathway. Journal of agricultural and food chemistry. 2024 Mar; 72(9):4703-4725. doi: 10.1021/acs.jafc.3c06370. [PMID: 38349207]
  • Tongjia Ni, Shuai Zhang, Jia Rao, Jiaqi Zhao, Haiqi Huang, Ying Liu, Yue Ding, Yaqian Liu, Yuchi Ma, Shoujun Zhang, Yang Gao, Liqian Shen, Chuanbo Ding, Yunpeng Sun. Phlorizin, an Important Glucoside: Research Progress on Its Biological Activity and Mechanism. Molecules (Basel, Switzerland). 2024 Feb; 29(3):. doi: 10.3390/molecules29030741. [PMID: 38338482]
  • Hui-Rong Bai, Jing Li, Li-Juan Lang, Yi Hao, Bei Jiang, Chao-Jiang Xiao. Crystal structure of phloridzin and its distribution changes in flowering and fruiting stage of Malus rockii. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2023 Nov; 78(11-12):383-387. doi: 10.1515/znc-2023-0046. [PMID: 37608519]
  • Yong Cheng, Xi Chen, Tian Yang, Zhaojun Wang, Qiuming Chen, Maomao Zeng, Fang Qin, Jie Chen, Zhiyong He. Effects of whey protein isolate and ferulic acid/phloridzin/naringin/cysteine on the thermal stability of mulberry anthocyanin extract at neutral pH. Food chemistry. 2023 Nov; 425(?):136494. doi: 10.1016/j.foodchem.2023.136494. [PMID: 37270886]
  • Wasundara Fernando, Rikki F Clark, H P Vasantha Rupasinghe, David W Hoskin, Melanie R Power Coombs. Phloridzin Docosahexaenoate Inhibits Spheroid Formation by Breast Cancer Stem Cells and Exhibits Cytotoxic Effects against Paclitaxel-Resistant Triple Negative Breast Cancer Cells. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914577. [PMID: 37834020]
  • Yule Wang, Yuduan Ding, Qian Zhao, Chen Wu, Cecilia H Deng, Jingru Wang, Yufan Wang, Yanfang Yan, Rui Zhai, Yar-Khing Yauk, Fengwang Ma, Ross G Atkinson, Pengmin Li. Dihydrochalcone glycoside biosynthesis in Malus is regulated by two MYB-like transcription factors and is required for seed development. The Plant journal : for cell and molecular biology. 2023 Aug; ?(?):. doi: 10.1111/tpj.16444. [PMID: 37648286]
  • Zhengming Xu, Shuang Liu, Huining Lai, Lijun You, Zhengang Zhao. Green-Efficient Enzymatic Synthesis and Characterization of Liposoluble 6'/6″-O-Lauryl Phenolic Glycosides with Enhanced Intestinal Permeability. Journal of agricultural and food chemistry. 2023 May; 71(20):7689-7702. doi: 10.1021/acs.jafc.3c00527. [PMID: 37167604]
  • Shiv Kumar, Jyoti Chhimwal, Suresh Kumar, Rahul Singh, Vikram Patial, Rituraj Purohit, Yogendra S Padwad. Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice. Life sciences. 2023 Apr; ?(?):121668. doi: 10.1016/j.lfs.2023.121668. [PMID: 37023949]
  • Yijia Jia, Xinyue Yan, Xiaotian Li, Shuang Zhang, Yuyang Huang, Dongmeng Zhang, Yang Li, Baokun Qi. Soy protein-phlorizin conjugate prepared by tyrosinase catalysis: Identification of covalent binding sites and alterations in protein structure and functionality. Food chemistry. 2023 Mar; 404(Pt A):134610. doi: 10.1016/j.foodchem.2022.134610. [PMID: 36257271]
  • Sukun Lin, Li Zhang, Peiwen Zhang, Rilin Huang, Muhammad Musa Khan, Shah Fahad, Dongmei Cheng, Zhixiang Zhang. Effects of glycosylation on the accumulation and transport of fipronil in earthworm (Eisenia fetida). Environmental science and pollution research international. 2023 Jan; 30(2):3688-3696. doi: 10.1007/s11356-022-22417-x. [PMID: 35953750]
  • Sei Saitoh, Takashi Takaki, Kazuki Nakajima, Bao Wo, Hiroshi Terashima, Satoshi Shimo, Huy Bang Nguyen, Truc Quynh Thai, Kanako Kumamoto, Kazuo Kunisawa, Shizuko Nagao, Akihiro Tojo, Nobuhiko Ohno, Kazuo Takahashi. Treatment of tubular damage in high-fat-diet-fed obese mice using sodium-glucose co-transporter inhibitors. PloS one. 2023; 18(2):e0281770. doi: 10.1371/journal.pone.0281770. [PMID: 36780539]
  • Simón Miranda, Stefano Piazza, Floriana Nuzzo, Mingai Li, Jorge Lagrèze, Axel Mithöfer, Alessandro Cestaro, Danuše Tarkowska, Richard Espley, Andrew Dare, Mickael Malnoy, Stefan Martens. CRISPR/Cas9 genome-editing applied to MdPGT1 in apple results in reduced foliar phloridzin without impacting plant growth. The Plant journal : for cell and molecular biology. 2023 01; 113(1):92-105. doi: 10.1111/tpj.16036. [PMID: 36401738]
  • Yijia Jia, Yishan Fu, Hui Man, Xinyue Yan, Yuyang Huang, Shiyan Sun, Baokun Qi, Yang Li. Comparative study of binding interactions between different dietary flavonoids and soybean β-conglycinin and glycinin: Impact on structure and function of the proteins. Food research international (Ottawa, Ont.). 2022 11; 161(?):111784. doi: 10.1016/j.foodres.2022.111784. [PMID: 36192935]
  • Li-Juan Lang, Min Wang, Chang Lei, Yi Shen, Qi-Jie Zhu, Hong-Mei Diao, Hao Chen, Lei Shen, Xiang Dong, Bei Jiang, Chao-Jiang Xiao. Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity. Planta medica. 2022 Oct; 88(13):1190-1198. doi: 10.1055/a-1716-0958. [PMID: 34875697]
  • Jinqian Chen, Hao Zhang, Xia Hu, Mengyuan Xu, Yanjun Su, Chunze Zhang, Yuan Yue, Xiaomin Zhang, Xinyu Wang, Wei Cui, Zhenyu Zhao, Xichuan Li. Phloretin exhibits potential food-drug interactions by inhibiting human UDP-glucuronosyltransferases in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Oct; 84(?):105447. doi: 10.1016/j.tiv.2022.105447. [PMID: 35868516]
  • Lili Tian, Majid Mufaqam Syed-Abdul, Priska Stahel, Gary F Lewis. Enteral glucose, absorbed and metabolized, potently enhances mesenteric lymph flow in chow- and high-fat-fed rats. American journal of physiology. Gastrointestinal and liver physiology. 2022 Oct; 323(4):G331-G340. doi: 10.1152/ajpgi.00095.2022. [PMID: 35916412]
  • Arzu Kavaz, Mesut Işık, Emrah Dikici, Mehmet Yüksel. Anticholinergic, Antioxidant, and Antibacterial Properties of Vitex Agnus-Castus L. Seed Extract: Assessment of Its Phenolic Content by LC/MS/MS. Chemistry & biodiversity. 2022 Oct; 19(10):e202200143. doi: 10.1002/cbdv.202200143. [PMID: 36075867]
  • Mohamed Marghich, Nour Elhouda Daoudi, Ouafa Amrani, Mohamed Addi, Christophe Hano, Jen-Tsung Chen, Hassane Mekhfi, Abderrahim Ziyyat, Mohamed Bnouham, Mohammed Aziz. Antioxidant Activity and Inhibition of Carbohydrate Digestive Enzymes Activities of Artemisia campestris L. Frontiers in bioscience (Scholar edition). 2022 09; 14(4):25. doi: 10.31083/j.fbs1404025. [PMID: 36575835]
  • Ebrahim Gholamalipour Alamdari, Akram Taleghani. New bioactive compounds characterized by liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry in hydro-methanol and petroleum ether extracts of Prosopis farcta (Banks & Sol.) J. F. Macbr weed. Journal of mass spectrometry : JMS. 2022 Sep; 57(9):e4884. doi: 10.1002/jms.4884. [PMID: 36128672]
  • Shuwen Sun, Mingqian Hao, Chuanbo Ding, Jinping Zhang, Qiteng Ding, Yiwen Zhang, Yingchun Zhao, Wencong Liu. SF/PVP nanofiber wound dressings loaded with phlorizin: preparation, characterization, in vivo and in vitro evaluation. Colloids and surfaces. B, Biointerfaces. 2022 Sep; 217(?):112692. doi: 10.1016/j.colsurfb.2022.112692. [PMID: 35834996]
  • September Numata, Jeff P McDermott, Gladis Sanchez, Amrita Mitra, Gustavo Blanco. The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertility†. Biology of reproduction. 2022 06; 106(6):1206-1217. doi: 10.1093/biolre/ioac052. [PMID: 35420639]
  • Congjian Ma, Yanjun Deng, Ran Xiao, Fan Xu, Mobai Li, Qihai Gong, Jianmei Gao. Anti-fatigue effect of phlorizin on exhaustive exercise-induced oxidative injury mediated by Nrf2/ARE signaling pathway in mice. European journal of pharmacology. 2022 Mar; 918(?):174563. doi: 10.1016/j.ejphar.2021.174563. [PMID: 34942162]
  • Kun Zhou, Lingyu Hu, Hong Yue, Zhijun Zhang, Jingyun Zhang, Xiaoqing Gong, Fengwang Ma. MdUGT88F1-mediated phloridzin biosynthesis coordinates carbon and nitrogen accumulation in apple. Journal of experimental botany. 2022 01; 73(3):886-902. doi: 10.1093/jxb/erab410. [PMID: 34486649]
  • Wan Yang, Hongdi Li, Jiayi Liu, Hua Shao, Juan Hua, Shihong Luo. Degraded Metabolites of Phlorizin Promote Germination of Valsa mali var. mali in its Host Malus spp. Journal of agricultural and food chemistry. 2022 Jan; 70(1):149-156. doi: 10.1021/acs.jafc.1c06206. [PMID: 34939801]
  • Ernest M Wright. SGLT2 Inhibitors: Physiology and Pharmacology. Kidney360. 2021 12; 2(12):2027-2037. doi: 10.34067/kid.0002772021. [PMID: 35419546]
  • Li Xiang, Mei Wang, Weitao Jiang, Yanfang Wang, Xuesen Chen, Chengmiao Yin, Zhiquan Mao. Key indicators for renewal and reconstruction of perennial trees soil: Microorganisms and phloridzin. Ecotoxicology and environmental safety. 2021 Dec; 225(?):112723. doi: 10.1016/j.ecoenv.2021.112723. [PMID: 34481354]
  • Kento Kitada, Satoshi Kidoguchi, Daisuke Nakano, Akira Nishiyama. Sodium/glucose cotransporter 2 and renoprotection: From the perspective of energy regulation and water conservation. Journal of pharmacological sciences. 2021 Nov; 147(3):245-250. doi: 10.1016/j.jphs.2021.07.006. [PMID: 34507633]
  • Jun-Zhi Wang, Yu Bian, Gai-Gai Deng, Yu Wang, Hua-Ling Yan, Xiao-Lan Zhang, Yong-Mei Huang, Ao Li, Xing-Yue Liao, Tian-Yan Feng. Effects of phloridzin on blood glucose and key enzyme G-6-Pase of gluconeogenesis in mice. Journal of food biochemistry. 2021 11; 45(11):e13956. doi: 10.1111/jfbc.13956. [PMID: 34590315]
  • Huazhen Liu, Yonger Chen, Yifan Wen, Shumin Zhu, Song Huang, Lian He, Shaozhen Hou, Xiaoping Lai, Shuxian Chen, Zhenhua Dai, Jian Liang. Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway. Journal of agricultural and food chemistry. 2021 Aug; 69(31):8671-8683. doi: 10.1021/acs.jafc.1c01645. [PMID: 34342231]
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