Phlorizin (BioDeep_00000398016)

Main id: BioDeep_00000000068

 

PANOMIX_OTCML-2023 Volatile Flavor Compounds natural product


代谢物信息卡片


1-[2,4-dihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]-3-(4-hydroxyphenyl)propan-1-one

化学式: C21H24O10 (436.13694039999996)
中文名称: 根皮苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O)C=C(O)C(C(=O)CCC2C=CC(O)=CC=2)=C(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=1
InChI: InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2

描述信息

Origin: Plant; Formula(Parent): C21H24O10; Bottle Name:Phloridzin; PRIME Parent Name:Phloretin-2-O-glucoside; PRIME in-house No.:S0307, Glycosides
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.718
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.713
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.714
Acquisition and generation of the data is financially supported by the Max-Planck-Society
IPB_RECORD: 2021; CONFIDENCE confident structure
Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.

同义名列表

56 个代谢物同义名

1-[2,4-dihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]-3-(4-hydroxyphenyl)propan-1-one; 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-phenyl]-3-(4-hydroxyphenyl)propan-1-one; 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-phenyl]-3-(4-hydroxyphenyl)propan-1-one; 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phenyl]-3-(4-hydroxyphenyl)propan-1-one; 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one; 1-Propanone, 1-(2-(beta-D-glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-; 1-Propanone, 1-[2-(beta-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-; 1-[2-(.beta.-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone; 2-(.beta.-D-glucopyranosyloxy)-4,6-dihydroxy-3-(4-hydroxyphenyl)propiophenone; 2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxy-3-(4-hydroxyphenyl)propiophenone; 3,5-dihydroxy-2-[3-(4-hydroxyphenyl)propanoyl]phenyl beta-D-glucopyranoside; 4,6-dihydroxy-2-(beta-D-glucosido)-beta-(p-hydroxyphenyl)propiophenone; Phloretin-2-beta-glucoside; SDCCGMLS-0066626.P001; Phloretin 2-glucoside; Phlorhizin;Phlorizin; EINECS 200-487-1; Spectrum5_000521; Spectrum4_001651; Spectrum2_000701; Spectrum3_001227; Spectrum_001291; NCGC00142423-01; SpecPlus_000325; SPECTRUM300547; DivK1c_006421; BSPBio_002674; KBioGR_002141; KBioSS_001771; SPBio_000881; KBio3_002174; KBio2_001771; ZINC03875408; KBio2_006907; Phloridzosid; KBio1_001365; KBio2_004339; Phlorrhizen; AIDS-009884; 112318-65-7; 16055-86-0; Phloridzin; AIDS009884; 52276-56-9; CHEBI:8113; Phlorhizin; AI3-19835; SBB005924; Phlorizin; Floridzin; NSC 2833; 60-81-1; C01604; 4,2,4,6-Tetrahydroxydihydroxychalcone 2-glucoside; Phlr-2p-Glc; Phlorizin



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

151 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Suping Zeng, Longhua Yu, Ping He, Hui Feng, Jia Wang, Huacong Zhang, Yunxia Song, Ren Liu, Yueqiao Li. Integrated transcriptome and metabolome analysis reveals the regulation of phlorizin synthesis in Lithocarpus polystachyus under nitrogen fertilization. BMC plant biology. 2024 May; 24(1):366. doi: 10.1186/s12870-024-05090-9. [PMID: 38711037]
  • Qian Zhao, Xiaoning Li, Yu Jiao, Ying Chen, Yanfang Yan, Yuzhu Wang, Cyril Hamiaux, Yule Wang, Fengwang Ma, Ross G Atkinson, Pengmin Li. Identification of two key genes involved in flavonoid catabolism and their different roles in apple resistance to biotic stresses. The New phytologist. 2024 May; 242(3):1238-1256. doi: 10.1111/nph.19644. [PMID: 38426393]
  • Chen-Mu Luo, Li-Fan Ke, Xiang-Yu Huang, Xiao-Yan Zhuang, Ze-Wang Guo, Qiong Xiao, Jun Chen, Fu-Quan Chen, Qiu-Ming Yang, Yi Ru, Hui-Fen Weng, An-Feng Xiao, Yong-Hui Zhang. Efficient biosynthesis of prunin in methanol cosolvent system by an organic solvent-tolerant α-L-rhamnosidase from Spirochaeta thermophila. Enzyme and microbial technology. 2024 Apr; 175(?):110410. doi: 10.1016/j.enzmictec.2024.110410. [PMID: 38340378]
  • Virgile Neyman, Maude Quicray, Frédéric Francis, Catherine Michaux. Toxicological, biochemical, and in silico investigations of three trehalase inhibitors for new ways to control aphids. Archives of insect biochemistry and physiology. 2024 Apr; 115(4):e22112. doi: 10.1002/arch.22112. [PMID: 38605672]
  • Xueran Mei, Yi Li, Xiaoyu Zhang, Xiwen Zhai, Yi Yang, Zhengjuan Li, Liping Li. Maternal Phlorizin Intake Protects Offspring from Maternal Obesity-Induced Metabolic Disorders in Mice via Targeting Gut Microbiota to Activate the SCFA-GPR43 Pathway. Journal of agricultural and food chemistry. 2024 Mar; 72(9):4703-4725. doi: 10.1021/acs.jafc.3c06370. [PMID: 38349207]
  • Tongjia Ni, Shuai Zhang, Jia Rao, Jiaqi Zhao, Haiqi Huang, Ying Liu, Yue Ding, Yaqian Liu, Yuchi Ma, Shoujun Zhang, Yang Gao, Liqian Shen, Chuanbo Ding, Yunpeng Sun. Phlorizin, an Important Glucoside: Research Progress on Its Biological Activity and Mechanism. Molecules (Basel, Switzerland). 2024 Feb; 29(3):. doi: 10.3390/molecules29030741. [PMID: 38338482]
  • Hui-Rong Bai, Jing Li, Li-Juan Lang, Yi Hao, Bei Jiang, Chao-Jiang Xiao. Crystal structure of phloridzin and its distribution changes in flowering and fruiting stage of Malus rockii. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2023 Nov; 78(11-12):383-387. doi: 10.1515/znc-2023-0046. [PMID: 37608519]
  • Yong Cheng, Xi Chen, Tian Yang, Zhaojun Wang, Qiuming Chen, Maomao Zeng, Fang Qin, Jie Chen, Zhiyong He. Effects of whey protein isolate and ferulic acid/phloridzin/naringin/cysteine on the thermal stability of mulberry anthocyanin extract at neutral pH. Food chemistry. 2023 Nov; 425(?):136494. doi: 10.1016/j.foodchem.2023.136494. [PMID: 37270886]
  • Wasundara Fernando, Rikki F Clark, H P Vasantha Rupasinghe, David W Hoskin, Melanie R Power Coombs. Phloridzin Docosahexaenoate Inhibits Spheroid Formation by Breast Cancer Stem Cells and Exhibits Cytotoxic Effects against Paclitaxel-Resistant Triple Negative Breast Cancer Cells. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914577. [PMID: 37834020]
  • Yule Wang, Yuduan Ding, Qian Zhao, Chen Wu, Cecilia H Deng, Jingru Wang, Yufan Wang, Yanfang Yan, Rui Zhai, Yar-Khing Yauk, Fengwang Ma, Ross G Atkinson, Pengmin Li. Dihydrochalcone glycoside biosynthesis in Malus is regulated by two MYB-like transcription factors and is required for seed development. The Plant journal : for cell and molecular biology. 2023 Aug; ?(?):. doi: 10.1111/tpj.16444. [PMID: 37648286]
  • Zhengming Xu, Shuang Liu, Huining Lai, Lijun You, Zhengang Zhao. Green-Efficient Enzymatic Synthesis and Characterization of Liposoluble 6'/6″-O-Lauryl Phenolic Glycosides with Enhanced Intestinal Permeability. Journal of agricultural and food chemistry. 2023 May; 71(20):7689-7702. doi: 10.1021/acs.jafc.3c00527. [PMID: 37167604]
  • Shiv Kumar, Jyoti Chhimwal, Suresh Kumar, Rahul Singh, Vikram Patial, Rituraj Purohit, Yogendra S Padwad. Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice. Life sciences. 2023 Apr; ?(?):121668. doi: 10.1016/j.lfs.2023.121668. [PMID: 37023949]
  • Yijia Jia, Xinyue Yan, Xiaotian Li, Shuang Zhang, Yuyang Huang, Dongmeng Zhang, Yang Li, Baokun Qi. Soy protein-phlorizin conjugate prepared by tyrosinase catalysis: Identification of covalent binding sites and alterations in protein structure and functionality. Food chemistry. 2023 Mar; 404(Pt A):134610. doi: 10.1016/j.foodchem.2022.134610. [PMID: 36257271]
  • Sukun Lin, Li Zhang, Peiwen Zhang, Rilin Huang, Muhammad Musa Khan, Shah Fahad, Dongmei Cheng, Zhixiang Zhang. Effects of glycosylation on the accumulation and transport of fipronil in earthworm (Eisenia fetida). Environmental science and pollution research international. 2023 Jan; 30(2):3688-3696. doi: 10.1007/s11356-022-22417-x. [PMID: 35953750]
  • Sei Saitoh, Takashi Takaki, Kazuki Nakajima, Bao Wo, Hiroshi Terashima, Satoshi Shimo, Huy Bang Nguyen, Truc Quynh Thai, Kanako Kumamoto, Kazuo Kunisawa, Shizuko Nagao, Akihiro Tojo, Nobuhiko Ohno, Kazuo Takahashi. Treatment of tubular damage in high-fat-diet-fed obese mice using sodium-glucose co-transporter inhibitors. PloS one. 2023; 18(2):e0281770. doi: 10.1371/journal.pone.0281770. [PMID: 36780539]
  • Simón Miranda, Stefano Piazza, Floriana Nuzzo, Mingai Li, Jorge Lagrèze, Axel Mithöfer, Alessandro Cestaro, Danuše Tarkowska, Richard Espley, Andrew Dare, Mickael Malnoy, Stefan Martens. CRISPR/Cas9 genome-editing applied to MdPGT1 in apple results in reduced foliar phloridzin without impacting plant growth. The Plant journal : for cell and molecular biology. 2023 01; 113(1):92-105. doi: 10.1111/tpj.16036. [PMID: 36401738]
  • Yijia Jia, Yishan Fu, Hui Man, Xinyue Yan, Yuyang Huang, Shiyan Sun, Baokun Qi, Yang Li. Comparative study of binding interactions between different dietary flavonoids and soybean β-conglycinin and glycinin: Impact on structure and function of the proteins. Food research international (Ottawa, Ont.). 2022 11; 161(?):111784. doi: 10.1016/j.foodres.2022.111784. [PMID: 36192935]
  • Li-Juan Lang, Min Wang, Chang Lei, Yi Shen, Qi-Jie Zhu, Hong-Mei Diao, Hao Chen, Lei Shen, Xiang Dong, Bei Jiang, Chao-Jiang Xiao. Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity. Planta medica. 2022 Oct; 88(13):1190-1198. doi: 10.1055/a-1716-0958. [PMID: 34875697]
  • Jinqian Chen, Hao Zhang, Xia Hu, Mengyuan Xu, Yanjun Su, Chunze Zhang, Yuan Yue, Xiaomin Zhang, Xinyu Wang, Wei Cui, Zhenyu Zhao, Xichuan Li. Phloretin exhibits potential food-drug interactions by inhibiting human UDP-glucuronosyltransferases in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Oct; 84(?):105447. doi: 10.1016/j.tiv.2022.105447. [PMID: 35868516]
  • Lili Tian, Majid Mufaqam Syed-Abdul, Priska Stahel, Gary F Lewis. Enteral glucose, absorbed and metabolized, potently enhances mesenteric lymph flow in chow- and high-fat-fed rats. American journal of physiology. Gastrointestinal and liver physiology. 2022 Oct; 323(4):G331-G340. doi: 10.1152/ajpgi.00095.2022. [PMID: 35916412]
  • Arzu Kavaz, Mesut Işık, Emrah Dikici, Mehmet Yüksel. Anticholinergic, Antioxidant, and Antibacterial Properties of Vitex Agnus-Castus L. Seed Extract: Assessment of Its Phenolic Content by LC/MS/MS. Chemistry & biodiversity. 2022 Oct; 19(10):e202200143. doi: 10.1002/cbdv.202200143. [PMID: 36075867]
  • Mohamed Marghich, Nour Elhouda Daoudi, Ouafa Amrani, Mohamed Addi, Christophe Hano, Jen-Tsung Chen, Hassane Mekhfi, Abderrahim Ziyyat, Mohamed Bnouham, Mohammed Aziz. Antioxidant Activity and Inhibition of Carbohydrate Digestive Enzymes Activities of Artemisia campestris L. Frontiers in bioscience (Scholar edition). 2022 09; 14(4):25. doi: 10.31083/j.fbs1404025. [PMID: 36575835]
  • Ebrahim Gholamalipour Alamdari, Akram Taleghani. New bioactive compounds characterized by liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry in hydro-methanol and petroleum ether extracts of Prosopis farcta (Banks & Sol.) J. F. Macbr weed. Journal of mass spectrometry : JMS. 2022 Sep; 57(9):e4884. doi: 10.1002/jms.4884. [PMID: 36128672]
  • Shuwen Sun, Mingqian Hao, Chuanbo Ding, Jinping Zhang, Qiteng Ding, Yiwen Zhang, Yingchun Zhao, Wencong Liu. SF/PVP nanofiber wound dressings loaded with phlorizin: preparation, characterization, in vivo and in vitro evaluation. Colloids and surfaces. B, Biointerfaces. 2022 Sep; 217(?):112692. doi: 10.1016/j.colsurfb.2022.112692. [PMID: 35834996]
  • September Numata, Jeff P McDermott, Gladis Sanchez, Amrita Mitra, Gustavo Blanco. The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertility†. Biology of reproduction. 2022 06; 106(6):1206-1217. doi: 10.1093/biolre/ioac052. [PMID: 35420639]
  • Congjian Ma, Yanjun Deng, Ran Xiao, Fan Xu, Mobai Li, Qihai Gong, Jianmei Gao. Anti-fatigue effect of phlorizin on exhaustive exercise-induced oxidative injury mediated by Nrf2/ARE signaling pathway in mice. European journal of pharmacology. 2022 Mar; 918(?):174563. doi: 10.1016/j.ejphar.2021.174563. [PMID: 34942162]
  • Kun Zhou, Lingyu Hu, Hong Yue, Zhijun Zhang, Jingyun Zhang, Xiaoqing Gong, Fengwang Ma. MdUGT88F1-mediated phloridzin biosynthesis coordinates carbon and nitrogen accumulation in apple. Journal of experimental botany. 2022 01; 73(3):886-902. doi: 10.1093/jxb/erab410. [PMID: 34486649]
  • Wan Yang, Hongdi Li, Jiayi Liu, Hua Shao, Juan Hua, Shihong Luo. Degraded Metabolites of Phlorizin Promote Germination of Valsa mali var. mali in its Host Malus spp. Journal of agricultural and food chemistry. 2022 Jan; 70(1):149-156. doi: 10.1021/acs.jafc.1c06206. [PMID: 34939801]
  • Ernest M Wright. SGLT2 Inhibitors: Physiology and Pharmacology. Kidney360. 2021 12; 2(12):2027-2037. doi: 10.34067/kid.0002772021. [PMID: 35419546]
  • Li Xiang, Mei Wang, Weitao Jiang, Yanfang Wang, Xuesen Chen, Chengmiao Yin, Zhiquan Mao. Key indicators for renewal and reconstruction of perennial trees soil: Microorganisms and phloridzin. Ecotoxicology and environmental safety. 2021 Dec; 225(?):112723. doi: 10.1016/j.ecoenv.2021.112723. [PMID: 34481354]
  • Kento Kitada, Satoshi Kidoguchi, Daisuke Nakano, Akira Nishiyama. Sodium/glucose cotransporter 2 and renoprotection: From the perspective of energy regulation and water conservation. Journal of pharmacological sciences. 2021 Nov; 147(3):245-250. doi: 10.1016/j.jphs.2021.07.006. [PMID: 34507633]
  • Jun-Zhi Wang, Yu Bian, Gai-Gai Deng, Yu Wang, Hua-Ling Yan, Xiao-Lan Zhang, Yong-Mei Huang, Ao Li, Xing-Yue Liao, Tian-Yan Feng. Effects of phloridzin on blood glucose and key enzyme G-6-Pase of gluconeogenesis in mice. Journal of food biochemistry. 2021 11; 45(11):e13956. doi: 10.1111/jfbc.13956. [PMID: 34590315]
  • Huazhen Liu, Yonger Chen, Yifan Wen, Shumin Zhu, Song Huang, Lian He, Shaozhen Hou, Xiaoping Lai, Shuxian Chen, Zhenhua Dai, Jian Liang. Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway. Journal of agricultural and food chemistry. 2021 Aug; 69(31):8671-8683. doi: 10.1021/acs.jafc.1c01645. [PMID: 34342231]
  • Zhenxian Jia, Yuning Xie, Hongjiao Wu, Zhuo Wang, Ang Li, Ze Li, Zhenbang Yang, Zhi Zhang, Zhaobin Xing, Xuemei Zhang. Phlorizin from sweet tea inhibits the progress of esophageal cancer by antagonizing the JAK2/STAT3 signaling pathway. Oncology reports. 2021 Jul; 46(1):. doi: 10.3892/or.2021.8088. [PMID: 34036398]
  • Jan Táborský, Josef Sus, Jaromír Lachman, Barbora Šebková, Anežka Adamcová, Dalibor Šatínský. Dynamics of Phloridzin and Related Compounds in Four Cultivars of Apple Trees during the Vegetation Period. Molecules (Basel, Switzerland). 2021 Jun; 26(13):. doi: 10.3390/molecules26133816. [PMID: 34206687]
  • Jie Xie, Jiang Chen, Xue-Ran Mei, Ming-Jun Zhu, Xue-Li Li, Juan Du, Xiao-Yu Zhang. Biotransformation of Phlorizin by Eurotium cristatum to Increase the Antioxidant and Antibacterial Activity of Docynia indica Leaves. Current microbiology. 2021 Apr; 78(4):1590-1601. doi: 10.1007/s00284-021-02366-3. [PMID: 33686505]
  • Sun-Young Yoon, Jae Sik Yu, Ji Young Hwang, Hae Min So, Seung Oh Seo, Jung Kyu Kim, Tae Su Jang, Sang J Chung, Ki Hyun Kim. Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061612. [PMID: 33799458]
  • Laura Ferté, Alice Marino, Sylvain Battault, Laurent Bultot, Anne Van Steenbergen, Anne Bol, Julien Cumps, Audrey Ginion, Hermann Koepsell, Laure Dumoutier, Louis Hue, Sandrine Horman, Luc Bertrand, Christophe Beauloye. New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans. American journal of physiology. Heart and circulatory physiology. 2021 02; 320(2):H838-H853. doi: 10.1152/ajpheart.00736.2019. [PMID: 33416451]
  • Harun Un, Rustem Anil Ugan, Muhammet Ali Gurbuz, Yasin Bayir, Aysenur Kahramanlar, Gokce Kaya, Elif Cadirci, Zekai Halici. Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation. Life sciences. 2021 Feb; 266(?):118869. doi: 10.1016/j.lfs.2020.118869. [PMID: 33309722]
  • Yali Yang, Hailiang Shen, Ting Liu, Yaoyao Wen, Furong Wang, Yurong Guo. Mitigation effects of phlorizin immersion on acrylamide formation in fried potato strips. Journal of the science of food and agriculture. 2021 Feb; 101(3):937-946. doi: 10.1002/jsfa.10701. [PMID: 32748961]
  • Lei Tian, Jianxin Cao, Tianrui Zhao, Yaping Liu, Afsar Khan, Guiguang Cheng. The Bioavailability, Extraction, Biosynthesis and Distribution of Natural Dihydrochalcone: Phloridzin. International journal of molecular sciences. 2021 Jan; 22(2):. doi: 10.3390/ijms22020962. [PMID: 33478062]
  • Dong Liu, Yanglin Ji, Yatu Guo, Hui Wang, Zijian Wu, Heyu Li, Hao Wang. Dietary Supplementation of Apple Phlorizin Attenuates the Redox State Related to Gut Microbiota Homeostasis in C57BL/6J Mice Fed with a High-Fat Diet. Journal of agricultural and food chemistry. 2021 Jan; 69(1):198-211. doi: 10.1021/acs.jafc.0c06426. [PMID: 33350821]
  • Wasundara Fernando, Kerry B Goralski, David W Hoskin, H P Vasantha Rupasinghe. Metabolism and pharmacokinetics of a novel polyphenol fatty acid ester phloridzin docosahexaenoate in Balb/c female mice. Scientific reports. 2020 12; 10(1):21391. doi: 10.1038/s41598-020-78369-0. [PMID: 33288802]
  • Xiao-Yu Zhang, Jiang Chen, Kang Yi, Ling Peng, Jie Xie, Xun Gou, Tong Peng, Lin Tang. Phlorizin ameliorates obesity-associated endotoxemia and insulin resistance in high-fat diet-fed mice by targeting the gut microbiota and intestinal barrier integrity. Gut microbes. 2020 11; 12(1):1-18. doi: 10.1080/19490976.2020.1842990. [PMID: 33222603]
  • Yanli Guo, Zheng Ran, Yongwei Zhang, Zhipeng Song, Lifeng Wang, Lan Yao, Minfang Zhang, Jialiang Xin, Xinmin Mao. Marein ameliorates diabetic nephropathy by inhibiting renal sodium glucose transporter 2 and activating the AMPK signaling pathway in db/db mice and high glucose-treated HK-2 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Nov; 131(?):110684. doi: 10.1016/j.biopha.2020.110684. [PMID: 33152903]
  • Emily J Prpa, Christopher P Corpe, Ben Atkinson, Brittany Blackstone, Elizabeth S Leftley, Priya Parekh, Mark Philo, Paul A Kroon, Wendy L Hall. Apple polyphenol-rich drinks dose-dependently decrease early-phase postprandial glucose concentrations following a high-carbohydrate meal: a randomized controlled trial in healthy adults and in vitro studies. The Journal of nutritional biochemistry. 2020 11; 85(?):108466. doi: 10.1016/j.jnutbio.2020.108466. [PMID: 32739411]
  • Catherine P Bondonno, Nicola P Bondonno, Sujata Shinde, Armaghan Shafaei, Mary C Boyce, Ewald Swinny, Steele R Jacob, Kevin Lacey, Richard J Woodman, Kevin D Croft, Michael J Considine, Jonathan M Hodgson. Phenolic composition of 91 Australian apple varieties: towards understanding their health attributes. Food & function. 2020 Aug; 11(8):7115-7125. doi: 10.1039/d0fo01130d. [PMID: 32744555]
  • Laise C da Silva, Mariana C Souza, Beatriz R Sumere, Luiz G S Silva, Diogo T da Cunha, Gerardo F Barbero, Rosangela M N Bezerra, Mauricio A Rostagno. Simultaneous extraction and separation of bioactive compounds from apple pomace using pressurized liquids coupled on-line with solid-phase extraction. Food chemistry. 2020 Jul; 318(?):126450. doi: 10.1016/j.foodchem.2020.126450. [PMID: 32151921]
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