Parietin (BioDeep_00000000367)

PANOMIX_OTCML-2023 Marine Natural Products

代谢物信息卡片

1,8-Dihydroxy-3-methoxy-6-methylanthraquinone, Emodin-3-methyl ether

化学式: C16H12O5 (284.0684702)
中文名称: 大黄素甲醚
谱图信息: 最多检出来源 Viridiplantae(plant) 9.92%

分子结构信息

SMILES: C12C(O)=CC(C)=CC=1C(=O)C1=C(C(O)=CC(OC)=C1)C2=O
InChI: InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3

描述信息

Physcion is a dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources. It has a role as an apoptosis inducer, an antineoplastic agent, a hepatoprotective agent, an anti-inflammatory agent, an antibacterial agent, an antifungal agent and a metabolite. It is functionally related to a 2-methylanthraquinone.
Physcion is a natural product found in Rumex dentatus, Ageratina altissima, and other organisms with data available.
See also: Reynoutria multiflora root (part of); Frangula purshiana Bark (part of).
A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.
[Raw Data] CBA82_Physcion_pos_10eV.txt
[Raw Data] CBA82_Physcion_pos_30eV.txt
[Raw Data] CBA82_Physcion_pos_50eV.txt
[Raw Data] CBA82_Physcion_pos_40eV.txt
[Raw Data] CBA82_Physcion_pos_20eV.txt

同义名列表

54 个代谢物同义名

数据库引用编号

22 个数据库交叉引用编号

ChEBI: CHEBI:38167
KEGG: C17045
PubChem: 10639
Metlin: METLIN43882
ChEMBL: CHEMBL42624
Wikipedia: Parietin
LipidMAPS: LMPK13040028
MeSH: physcione
ChemIDplus: 0000521619
chemspider: 10193
CAS: 521-61-9
MoNA: FIO00996
MoNA: FIO00998
MoNA: FIO00995
MoNA: FIO00997
MoNA: FIO00994
medchemexpress: HY-N0108
PMhub: MS000011887
MetaboLights: MTBLC38167
PubChem: 96023523
KNApSAcK: C00019420
NIKKAJI: J11.586J

分类词条

Anthracenes and phenanthrenes [PK1304]

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

152 个相关的物种来源信息

384659 - Achyranthes bidentata: 10.17660/ACTAHORTIC.1996.426.7
102750 - Ageratina altissima: 10.1515/ZNB-2005-0916
48098 - Alternaria porri: 10.1080/00021369.1975.10861943
2686329 - Alvaradoa jamaicensis: 10.1021/NP980300I
49857 - Annona montana: 10.1016/S0031-9422(00)82257-8
35608 - Artemisia annua: 10.1016/S0278-6915(99)00027-7
182096 - Aspergillus chevalieri: 10.1021/JF60226A021
5059 - Aspergillus flavus: 10.1039/P19720002406
41413 - Aspergillus glaucus: 10.1021/NP800303T
396024 - Aspergillus ruber:
33178 - Aspergillus terreus: 10.1016/J.PHYTOCHEM.2008.10.017
5066 - Aspergillus wentii: 10.1021/JF00106A023
72168 - Berchemia discolor: 10.1016/0031-9422(92)83730-M
1226760 - Berchemia floribunda: 10.1248/CPB.56.1248
78707 - Bletilla striata: 10.1016/0031-9422(91)85139-Q
1443952 - Bourreria pulchra: 10.1016/J.PHYTOL.2009.10.002
1301227 - Calogaya pusilla: 10.1016/S0031-9422(00)85380-7
53851 - Cassia:
53852 - Cassia fistula:
162709 - Cassia grandis: 10.1021/NP50034A033
508996 - Cassia javanica:
1231245 - Cassia renigera: 10.1021/NP50034A033
948717 - Cassia roxburghii:
38033 - Chaetomium globosum: 10.1021/NP060248N
1526916 - Chamaecrista pumila:
103745 - Chromolaena odorata: 10.1515/ZNB-2005-0916
13427 - Cichorium intybus: 10.1016/S0278-6915(99)00027-7
742017 - Cortinarius basirubescens: 10.1016/J.PHYTOCHEM.2010.03.016
309013 - Cortinarius canarius:
304759 - Cortinarius sanguineus: 10.1515/ZNC-2000-3-410
271748 - Cratoxylum arborescens: 10.1055/S-2006-951725
198761 - Cratoxylum formosum: 10.1016/J.TET.2006.06.003
52844 - Cryptolepis nigrescens: 10.4268/CJCMM20150419
392618 - Cunila: 10.1007/S00299-018-2303-8
117954 - Dendrobium loddigesii: 10.1021/NP50111A014
117978 - Dendrobium thyrsiflorum: 10.1016/J.PHYTOCHEM.2005.04.001
47341 - Dermocybe:
1225674 - Derris cuneifolia:
52152 - Elymus repens: 10.1016/S0278-6915(99)00027-7
142771 - Entodon luridus: 10.4268/CJCMM20161809
102770 - Eupatorium cannabinum: 10.1002/CHIN.200516156
3617 - Fagopyrum esculentum: 10.1016/S0278-6915(99)00027-7
76025 - Fallopia multiflora:
76036 - Fallopia sachalinensis: 10.1007/BF02751107
461588 - Fibraurea tinctoria: 10.1016/J.BMC.2008.09.023
78068 - Flavocetraria cucullata: 10.1016/0031-9422(82)80041-1
266091 - Gynochthodes officinalis:
43717 - Harrisonia perforata: 10.3987/COM-95-7348
198768 - Harungana madagascariensis:
557660 - Inula salsoloides: 10.1002/HLCA.201000195
4236 - Lactuca sativa: 10.1016/S0278-6915(99)00027-7
694369 - Leucosceptrum canum: 10.1016/J.PHYTOL.2009.10.007
159053 - Limonia acidissima: 10.1021/NP50047A022
106689 - Maesopsis eminii: 10.1016/S0031-9422(00)85747-7
1712206 - Millettia leucantha: 10.1007/S12272-011-0603-4
43522 - Morinda citrifolia:
4530 - Oryza sativa: 10.3390/MOLECULES16031917
69774 - Penicillium herquei: 10.1021/NP50084A019
46901 - Persicaria hydropiper: 10.1016/S0024-3205(97)00937-5
3888 - Pisum sativum: 10.1016/S0278-6915(99)00027-7
101996 - Plantago coronopus: 10.1016/S0278-6915(99)00027-7
39414 - Plantago lanceolata: 10.1016/S0278-6915(99)00027-7
3615 - Polygonaceae: 10.1016/J.EJPS.2012.10.027
158314 - Polyporus umbellatus: 10.1007/S10600-009-9229-X
173545 - Polysiphonia stricta: 10.1021/NP060248N
65404 - Polysiphonia urceolata: 10.1021/NP060248N
69778 - Pseudopenicillium megasporum: 10.1016/0031-9422(89)80145-1
999612 - Psorospermum androsaemifolium: 10.1002/CJOC.201190065
643230 - Ramalina hierrensis: 10.1055/S-2006-961433
3610 - Rhamnus cathartica: 10.1076/PHBI.38.5.321.5965
1813053 - Rhamnus formosana: 10.1016/0031-9422(90)85356-K
1813059 - Rhamnus kurdica: 10.3109/13880209209053982
1813207 - Rhamnus nakaharae: 10.1021/NP50085A021
280022 - Rhamnus prinoides:
1813066 - Rhamnus procumbens: 10.1002/PTR.2650020109
1778787 - Rhamnus punctata: 10.3109/13880209209053982
1630248 - Rhamnus virgata: 10.1016/S0305-1978(00)00014-4
1819798 - Rhamnus wightii: 10.1016/0031-9422(91)83502-C
3620 - Rheum: 10.1002/(SICI)1099-0801(199807/08)12:4<193::AID-BMC729>3.0.CO;2-7
694412 - Rheum acuminatum: 10.1016/0378-8741(84)90016-3
284362 - Rheum alexandrae: 10.1016/0378-8741(84)90016-3
574896 - Rheum altaicum: 10.1016/0378-8741(84)90016-3
284363 - Rheum australe:
137216 - Rheum compactum: 10.1016/0378-8741(84)90016-3
240185 - Rheum coreanum: 10.1016/S0031-9422(00)00370-8
694413 - Rheum delavayi:
240182 - Rheum franzenbachii:
137217 - Rheum hotaoense: 10.1016/0378-8741(84)90016-3
240183 - Rheum kialense: 10.1016/0378-8741(84)90016-3
137218 - Rheum likiangense: 10.1016/0378-8741(84)90016-3
137219 - Rheum nanum: 10.1055/S-2008-1074562
137697 - Rheum nobile: 10.1016/0378-8741(84)90016-3
137220 - Rheum officinale:
137221 - Rheum palmatum:
137223 - Rheum pumilum: 10.1016/0378-8741(84)90016-3
2743666 - Rheum racemiferum:
137224 - Rheum reticulatum: 10.1016/0378-8741(84)90016-3
3621 - Rheum rhabarbarum:
46087 - Rheum rhaponticum:
240184 - Rheum spiciforme: 10.1016/0378-8741(84)90016-3
137225 - Rheum sublanceolatum: 10.1055/S-2008-1074562
137226 - Rheum tanguticum:
205071 - Rheum tataricum: 10.1016/0378-8741(84)90016-3
137227 - Rheum undulatum:
137228 - Rheum wittrockii: 10.1016/0378-8741(84)90016-3
267261 - Rosa villosa: 10.1016/S0031-9422(00)86709-6
339321 - Rubia cordifolia: 10.1002/CHIN.200701211
3618 - Rumex: 10.1016/J.BMCL.2013.04.059
273505 - Rumex abyssinicus:
41241 - Rumex acetosa:
174649 - Rumex crispus:
278676 - Rumex cristatus: 10.1042/BJ0980112
1006352 - Rumex dentatus: 10.1016/S0031-9422(01)00337-5
174651 - Rumex japonicus:
174652 - Rumex nepalensis:
137229 - Rumex patientia: 10.1016/S0031-9422(01)00337-5
242528 - Rumex scutatus: 10.1515/ZNC-1997-9-1014
268908 - Salvia greggii: 10.1016/S0031-9422(01)00341-7
38868 - Salvia officinalis: 10.1016/S0031-9422(01)00341-7
281910 - Sanguisorba alpina: 10.1016/0031-9422(92)80123-V
54806 - Saururus chinensis: 10.3987/COM-95-7370
72402 - Senna alexandrina:
346948 - Senna artemisioides: 10.1080/10286020.2010.534081
346959 - Senna corymbosa: 10.1016/0031-9422(92)80483-U
72401 - Senna didymobotrya:
1842781 - Senna gaudichaudii: 10.1055/S-0028-1097458
346974 - Senna italica: 10.18052/WWW.SCIPRESS.COM/ILCPA.14.146
162908 - Senna lindheimeriana: 10.1016/0031-9422(92)80483-U
2601745 - Senna longiracemosa: 10.1016/S0031-9422(00)95104-5
1574110 - Senna multiglandulosa: 10.1016/0031-9422(95)00645-1
346985 - Senna obtusifolia:
126820 - Senna occidentalis:
992784 - Senna petersiana: 10.1016/S0367-326X(00)00155-6
346998 - Senna septemtrionalis:
346999 - Senna siamea:
1977557 - Senna singueana: 10.1055/S-2006-960945
948718 - Senna sophera:
948714 - Senna sulfurea: 10.1055/S-0028-1097458
362788 - Senna tora:
347010 - Senna villosa: 10.1016/S0031-9422(00)94783-6
285508 - Streptomyces piomogenus: 10.1016/J.STEROIDS.2018.06.005
210369 - Tribulus terrestris: 10.1055/S-0036-1578747
43575 - Uncaria rhynchophylla: 10.1007/S10600-018-2478-9
1390085 - Ventilago denticulata:
345802 - Ventilago madraspatana: 10.1111/J.2042-7158.2010.01151.X
1137045 - Vismia cayennensis:
999598 - Vismia guianensis: 10.1016/S0031-9422(00)95279-8
999599 - Vismia guineensis: 10.1021/NP990226J
1348480 - Vismia latifolia: 10.1002/1097-458X(200012)38:12<1027::AID-MRC777>3.0.CO;2-3
2704497 - Vismia laurentii:
29760 - Vitis vinifera: 10.1016/S0278-6915(99)00027-7
33090 - 大黄: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Lu Liu, Sen Sun, Xiaohua Li. Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes. Pharmaceutical biology. 2024 Dec; 62(1):207-213. doi: 10.1080/13880209.2024.2314089. [PMID: 38353248]
Huang-Fei Jin, Qian-Xue Shen, Ying Shi, Fang-Ming Liu, Bin Wang, Jun Cao, Li-Hong Ye. Magnetic-stirring-enhanced mechanical amorphous dispersion extraction for the hydrophobic phytochemical constituents using an aqueous solution from a medicinal plant. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116191. doi: 10.1016/j.jpba.2024.116191. [PMID: 38728950]
Ruojun Du, Lichun Ye, Xinyan Chen, Yan Meng, Lei Zhou, Qiao Chen, Guohua Zheng, Junjie Hu, Zhaohua Shi. Screening of Key Components for Melanogenesis Inhibition of Polygonum cuspidatum Extract Based on the Spectrum-Effect Relationship and Molecular Docking. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040857. [PMID: 38398609]
Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Xiaohong Gong, Yunxia Li. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):111-121. doi: 10.1007/s13318-023-00875-z. [PMID: 38112917]
Mohamed Mendili, Ayda Khadhri, Francesca Sabatini, Ilaria Degano, Samira Aschi-Smiti. Parietin, the Vibrant Natural Dye in Xanthoria parietina. Chemistry & biodiversity. 2024 Jan; 21(1):e202301357. doi: 10.1002/cbdv.202301357. [PMID: 38072912]
Jan Schulze, Lisa Schöne, Abdallah M Ayoub, Damiano Librizzi, Muhammad Umair Amin, Konrad Engelhardt, Behrooz H Yousefi, Lena Bender, Jens Schaefer, Eduard Preis, Michaela Schulz-Siegmund, Christian Wölk, Udo Bakowsky. Modern Photodynamic Glioblastoma Therapy Using Curcumin- or Parietin-Loaded Lipid Nanoparticles in a CAM Model Study. ACS applied bio materials. 2023 Dec; 6(12):5502-5514. doi: 10.1021/acsabm.3c00695. [PMID: 38016693]
Shuxiang Zhang, Zhongdi Huang, Huanhuan Xu, Qihua Liu, Zhou Jiang, Caiping Yin, Guomin Han, Wei Zhang, Yinglao Zhang. Biological control of wheat powdery mildew disease by the termite-associated fungus Aspergillus chevalieri BYST01 and potential role of secondary metabolites. Pest management science. 2023 Dec; ?(?):. doi: 10.1002/ps.7938. [PMID: 38105413]
Martyna Nowak-Perlak, Piotr Ziółkowski, Marta Woźniak. A promising natural anthraquinones mediated by photodynamic therapy for anti-cancer therapy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Oct; 119(?):155035. doi: 10.1016/j.phymed.2023.155035. [PMID: 37603973]
ShengHao Chen, YanLan Liang, YuanYuan Li, Yue Sun, Yang He. Determination of rhein and physcion in rhubarb by microchip capillary electrophoresis in mixed hydro-organic solvent combined with laser-induced fluorescence detection. Journal of separation science. 2023 Jul; ?(?):e2300192. doi: 10.1002/jssc.202300192. [PMID: 37507831]
H Wang, M Li, S Li, J Shi, L Huang, S Cheng, C Zou, H Yan. [Spectrum-effect relationship of total anthraquinone extract of Cassia seeds against fluorouracil-induced liver injury in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 May; 43(5):825-831. doi: 10.12122/j.issn.1673-4254.2023.05.19. [PMID: 37313825]
Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
Hanaa M Sayed, Mahmoud A Ramadan, Heba H Salem, Iqrar Ahmad, Harun Patel, Marwa A A Fayed. Phytochemical Investigation, In silico/In vivo Analgesic, and Anti-inflammatory Assessment of the Egyptian Cassia occidentalis L. Steroids. 2023 May; 196(?):109245. doi: 10.1016/j.steroids.2023.109245. [PMID: 37141980]
Dongpeng Wang, Jufeng Duan, Xiao-Jing Chen, Kaiqi Liu, Yingying Guo, Run Shi, Sha Li, Ming Liu, Lijun Zhao, Bei Li, Hongtao Liu, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang. Pharmacokinetic characteristics of emodin in polygoni Multiflori Radix Praeparata. Journal of ethnopharmacology. 2023 Mar; 303(?):115945. doi: 10.1016/j.jep.2022.115945. [PMID: 36435407]
Yongpeng Yao, ErLan Yang, Yuanyuan Pan, Xian Shu, Gang Liu. Mining an O-methyltransferase for de novo biosynthesis of physcion in Aspergillus nidulans. Applied microbiology and biotechnology. 2023 Feb; 107(4):1177-1188. doi: 10.1007/s00253-023-12373-y. [PMID: 36648527]
Feifei Qi, Wei Zhang, Yingying Xue, Ce Geng, Zhigang Jin, Jibin Li, Qiang Guo, Xuenian Huang, Xuefeng Lu. Microbial production of the plant-derived fungicide physcion. Metabolic engineering. 2022 11; 74(?):130-138. doi: 10.1016/j.ymben.2022.10.007. [PMID: 36328293]
Bo Yuan, Nancy P Keller, Berl R Oakley, Jason E Stajich, Clay C C Wang. Manipulation of the Global Regulator mcrA Upregulates Secondary Metabolite Production in Aspergillus wentii Using CRISPR-Cas9 with In Vitro Assembled Ribonucleoproteins. ACS chemical biology. 2022 10; 17(10):2828-2835. doi: 10.1021/acschembio.2c00456. [PMID: 36197945]
Xiaolei Du, Lili Xu, Zhe Zhang, Yang Wang, Huifen Li, Weiliang Cui, Huibin Lin. Analyze the Effect of Steaming on the Chemical Constituents, Defecation and Liver Injury of Polygonum Multiflorum Radix (Heshouwu) by Multiple Analysis Techniques Combined with Multivariate Statistics. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196284. [PMID: 36234820]
Chwan-Fwu Lin, Shih-Yi Chuang, Tse-Hung Huang, Thi My Huyen Nguyen, Pei-Wen Wang, Ahmed Alalaiwe, Jia-You Fang. A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112482. doi: 10.1016/j.biopha.2021.112482. [PMID: 34915669]
Zizhao Lao, Yaohua Fan, Yuhang Huo, Feng Liao, Rongwen Zhang, Bei Zhang, Ziyun Kong, Haishan Long, Jieliang Xie, Chuanlan Sang, Ludi Fu, Ji Lin, Yina Wu, Liangwen Yu, Geng Li. Physcion, a novel inhibitor of 5α-reductase that promotes hair growth in vitro and in vivo. Archives of dermatological research. 2022 Jan; 314(1):41-51. doi: 10.1007/s00403-021-02195-1. [PMID: 33635414]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Xiao Wei Ji, Hang Ji Lyu, Guang Hai Zhou, Bo Wu, Yuan Yuan Zhu, Tian Hua Wu, Feng Zhang, Song Nan Jin, Kyung Woo Cho, Jin Fu Wen. Physcion, a tetra-substituted 9,10-anthraquinone, prevents homocysteine-induced endothelial dysfunction by activating Ca2+- and Akt-eNOS-NO signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jan; 81(?):153410. doi: 10.1016/j.phymed.2020.153410. [PMID: 33285470]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
XunLi, Yingjiao Liu, Shifeng Chu, Songwei Yang, Ye Peng, Siyu Ren, Birui Wen, Naihong Chen. Physcion and physcion 8-O-β-glucopyranoside: A review of their pharmacology, toxicities and pharmacokinetics. Chemico-biological interactions. 2019 Sep; 310(?):108722. doi: 10.1016/j.cbi.2019.06.035. [PMID: 31226286]
Bing Yang, Li Xie, Siying Peng, Kanping Sun, Junjie Jin, Yanping Zhen, Kunming Qin, Baochang Cai. Nine components pharmacokinetic study of rat plasma after oral administration raw and prepared Semen Cassiae in normal and acute liver injury rats. Journal of separation science. 2019 Jul; 42(14):2341-2350. doi: 10.1002/jssc.201900007. [PMID: 31037812]
Rong-Rong Li, Xue-Fang Liu, Su-Xiang Feng, Sheng-Nan Shu, Pei-Yang Wang, Na Zhang, Jian-Sheng Li, Ling-Bo Qu. Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101898. [PMID: 31108858]
Phil-Dong Moon, Na-Ra Han, Jin Soo Lee, Sungwei Hong, Min-Sun Yoo, Hyeong-Jin Kim, Ji-Hyeon Kim, Soonsik Kang, Hyun-Woo Jee, Hyung-Min Kim, Hyun-Ja Jeong. Use of Physcion to Improve Atopic Dermatitis-Like Skin Lesions through Blocking of Thymic Stromal Lymphopoietin. Molecules (Basel, Switzerland). 2019 Apr; 24(8):. doi: 10.3390/molecules24081484. [PMID: 30991764]
Kun-Ze Du, Ying Chen, Jin Li, Ge Tang, Fei Tian, Jun He, Yanxu Chang. Quantification of eight active ingredients in crude and processed radix polygoni multiflori applying miniaturized matrix solid-phase dispersion microextraction followed by UHPLC. Journal of separation science. 2018 Sep; 41(17):3486-3495. doi: 10.1002/jssc.201800342. [PMID: 30028075]
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