Crustecdysone (BioDeep_00000002779)

Secondary id: BioDeep_00000171790, BioDeep_00000407045, BioDeep_00000410545

human metabolite PANOMIX_OTCML-2023 Endogenous Marine Natural Products

代谢物信息卡片

(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-((2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl)-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]phenanthren-6-one

化学式: C27H44O7 (480.3087)
中文名称: β-蜕皮激素, 蜕皮激素, β-蜕皮甾酮
谱图信息: 最多检出来源 Homo sapiens(feces) 24.61%

分子结构信息

SMILES: C1[C@H](O)[C@H](O)C[C@@]2([H])C(=O)C=C3[C@@](CC[C@]4([C@@]3(O)CC[C@]4([H])[C@](O)(C)[C@H](O)CCC(O)(C)C)C)([H])[C@]21C
InChI: InChI=1S/C27H44O7/c1-23(2,32)9-8-22(31)26(5,33)21-7-11-27(34)16-12-18(28)17-13-19(29)20(30)14-24(17,3)15(16)6-10-25(21,27)4/h12,15,17,19-22,29-34H,6-11,13-14H2,1-5H3/t15-,17-,19+,20-,21-,22+,24+,25+,26+,27+/m0/s1

描述信息

20-hydroxyecdysone is an ecdysteroid that is ecdysone substituted by a hydroxy group at position 20. It has a role as a plant metabolite and an animal metabolite. It is a 20-hydroxy steroid, an ecdysteroid, a 14alpha-hydroxy steroid, a 3beta-sterol, a 2beta-hydroxy steroid, a 22-hydroxy steroid, a 25-hydroxy steroid and a phytoecdysteroid. It is functionally related to an ecdysone.
20-Hydroxyecdysone is a natural product found in Asparagus filicinus, Trichobilharzia ocellata, and other organisms with data available.
A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE.
Crustecdysone is found in crustaceans. Crustecdysone is isolated from the marine crayfish Jasus lalandei in low yield (2 mg/ton
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
An ecdysteroid that is ecdysone substituted by a hydroxy group at position 20.
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Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)[3].
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)[3].

同义名列表

74 个代谢物同义名

(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-((2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl)-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]phenanthren-6-one; (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one; (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(1R,2R)-1,2,5-trihydroxy-1,5-dimethyl-hexyl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one; (1R,2R,4S,5R,7R,11S,14S,15R)-4,5,11-trihydroxy-2,15-dimethyl-14-[(2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-9-en-8-one; 2,3,14-Trihydroxy-10,13-dimethyl-17-(1,2,5-trihydroxy-1,5-dimethyl-hexyl)-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-6-one; Cholest-7-en-6-one, 2,3,14,20,22,25-hexahydroxy-, (2.beta.,3.beta.,5.beta.,22R)-; Cholest-7-en-6-one, 2,3,14,20,22,25-hexahydroxy-, (2-beta,3-beta,5-beta,22R)-; Cholest-7-en-6-one, 2,3,14,20,22,25-hexahydroxy-, (2beta,3beta,5beta,22R)-; 5-beta-Cholest-7-en-6-one, 2-beta,3-beta,14,20,22,25-hexahydroxy-, (22R)-; (2alpha,3alpha,5alpha,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one; (22R)-2beta,3beta,14alpha,20,22,25-hexahydroxy-5beta-cholest-7-en-6-one; (2beta,3beta,5beta,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one; 2beta,3beta,14alpha,20R,22R,25-hexahydroxy-5beta-cholest-7-en-6-one; 2beta,3beta,14alpha,20beta,22alpha,25-Hexahydroxycholest-7-en-6-one; 2beta,3beta,14alpha,20,22R,25-hexahydroxy-5beta-cholest-7-en-6-one; Cholest-7-en-6-one, 2,3,14,20,22,25-hexahydroxy-, (2b,3b,5b,22R)-; (2Beta,3beta,5beta)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one; 2-beta,3-beta,14,20,22,25-Hexahydroxy-5-beta-cholet-7-en-6- one; 2-beta,3-beta,14,20,22,25-Hexahydroxy-5-beta-cholet-7-en-6-one; (2b,3b,5b,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one; (2β,3β,5β,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one; 2β,3β,14α,20β,22α,25-Hexahydroxycholest-7-en-6-one; 20-Hydroxyecdysone, >=93\\% (HPLC), powder; 20-HYDROXY-.ALPHA.-ECDYSONE; 20-HYDROXYECDYSONE [WHO-DD]; NKDFYOWSKOHCCO-YPVLXUMRSA-N; 20-Hydroxy-alpha-ecdysone; 20-HYDROXYECDYSONE [MI]; B-ecdysone,Commisterone; (+)-20-Hydroxyecdysone; 20-Hydroxy-a-ecdysone; 20-Hydroxy-α-ecdysone; 20R-Hydroxyecdysone; 20 Hydroxyecdysone; 20-Hydroxyecdysone; 20-Hydroxyecdyson; .beta-Ecdysterone; beta-ECDYSTERONE; Isoinokosterone; Hydroxyecdysone; (+)-Ecdysterone; beta-Ecydisone; 20-OH ecdysone; beta-Ecdysone; b-Ecdysterone; Crustecdysone; beta-Ecdisone; Beta Ecdysone; Viticosterone; β-Ecdysterone; Crustecdyson; Commisterone; Polypodine A; Polypodine C; Polypodin C; Ecdysterone; Polypodin A; β-Ecydisone; ?- Ecdysone; ST 27:2;O7; b-Ecdysone; Edysterone; Ecdysteron; Β-ecdysone; AI3-44727; Ecdystene; Sarconeos; Ecdysten; Ekdisten; THE-7; 20-E; 20E; (2S,3R,5R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one; 20-Hydroxyecdysone

数据库引用编号

25 个数据库交叉引用编号

ChEBI: CHEBI:16587
KEGG: C02633
PubChem: 5459840
PubChem: 271605
PubChem: 439770
HMDB: HMDB0030180
DrugBank: DB16935
ChEMBL: CHEMBL224128
Wikipedia: 20-Hydroxyecdysone
LipidMAPS: LMST01010209
MeSH: Ecdysterone
ChemIDplus: 0005289747
MetaCyc: CPD-276
KNApSAcK: C00003654
KNApSAcK: C00048286
chemspider: 4573597
CAS: 5289-74-7
medchemexpress: HY-N6979
PMhub: MS000004946
MetaboLights: MTBLC16587
PubChem: 5613
PDB-CCD: 20E
3DMET: B04858
NIKKAJI: J13.425B
KNApSAcK: 16587

分类词条

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

Molting Hormone Biosynthesis: Cholesterol + Hydrogen Ion + NADH + Oxygen ⟶ 7-Dehydrocholesterol + NAD + Water

PharmGKB(0)

170 个相关的物种来源信息

240005 - Achyranthes aspera: 10.1007/PL00010306
384659 - Achyranthes bidentata: 10.1016/0040-4020(76)80160-3
384659 - Achyranthes bidentata Bl.: -
165205 - Afrocarpus gracilior: 10.1016/J.PHYTOL.2012.02.005
295252 - Agelas dispar:
295252 - Agelas dispar: 10.1021/NP970323H
1736745 - Ajuga chamaecistus: 10.1016/S0021-9673(01)88168-1
49984 - Ajuga chamaepitys: 10.1016/S0031-9422(00)84101-1
167911 - Ajuga decumbens: 10.1248/CPB.17.340
2026104 - Ajuga iva: 10.1016/S0031-9422(00)97527-7
984302 - Ajuga nipponensis: 10.1248/CPB.17.340
38596 - Ajuga reptans:
41472 - Amberboa moschata: 10.1016/S0305-1978(97)00018-5
470566 - Anemone alpina: 10.1016/S0305-1978(97)00042-2
387932 - Anemone montana: 10.1016/S0305-1978(97)00042-2
174168 - Anemone occidentalis: 10.1016/S0305-1978(97)00042-2
445234 - Anemone pulsatilla: 10.1016/S0305-1978(97)00042-2
7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
72517 - Arilus cristatus: 10.1007/BF01946477
6252 - Ascaris lumbricoides: 10.1007/BF01923635
100515 - Asparagus filicinus: 10.1016/S0031-9422(99)00051-5
65704 - Athyrium yokoscense: 10.1016/0031-9422(95)00688-5
3553 - Atriplex nummularia: 10.1016/S0367-326X(99)00159-8
376799 - Atriplex portulacoides: 10.1016/J.BMCL.2015.03.028
464020 - Axyris amaranthoides: 10.1016/S0031-9422(98)00446-4
6526 - Biomphalaria glabrata: 10.1007/BF01959769
49702 - Blandfordia punicea: 10.1021/NP960377B
122298 - Blitum bonus-henricus: 10.1016/0031-9422(82)80057-5
7091 - Bombyx mori:
120713 - Brainea insignis: 10.1016/J.PHYTOCHEM.2010.03.002
41536 - Centaurea melitensis:
80839 - Charybdis japonica: 10.1073/PNAS.86.17.6826
46091 - Chenopodiastrum murale: 10.1002/(SICI)1520-6327(1999)41:1<18::AID-ARCH4>3.0.CO;2-T
3559 - Chenopodium album:
882375 - Chenopodium pallidicaule: 10.1016/0305-1978(96)00019-1
63459 - Chenopodium quinoa:
63459 - Chenopodium quinoa: 10.1021/JF0014462
79782 - Cimex lectularius: 10.1007/BF01946477
87754 - Cistanche phelypaea: 10.1248/CPB.38.1927
161397 - Cistanche tubulosa: 10.1248/CPB.38.1927
6535 - Cornu aspersum: 10.1007/BF01959769
1503182 - Cyanotis arachnoidea: 10.1080/10286020290019631
384660 - Cyathula officinalis Kuan: -
84614 - Cyrtomium falcatum: 10.1248/CPB.17.340
4164 - Digitalis purpurea: 10.1007/S10600-010-9551-3
152356 - Diploclisia: 10.1055/S-2007-969388
152357 - Diploclisia glaucescens:
191328 - Dysdercus cingulatus: 10.1007/BF01946477
527504 - Fibraurea chloroleuca: 10.1002/PTR.2650070406
461588 - Fibraurea tinctoria: 10.1002/PTR.2650070406
46114 - Froelichia floridana:
59080 - Gagea serotina: 10.1016/S0305-1978(01)00021-7
2528985 - Gomphrena affinis: 10.1016/S0305-1978(97)00106-3
2528987 - Gomphrena canescens: 10.1016/S0305-1978(97)00106-3
2528988 - Gomphrena cunninghamii: 10.1016/S0305-1978(97)00106-3
221775 - Gomphrena globosa: 10.1016/S0305-1978(97)00106-3
240061 - Gomphrena haageana: 10.1016/S0305-1978(97)00106-3
221778 - Gomphrena serrata: 10.1016/S0305-1978(97)00106-3
2873767 - Haematocarpus subpeltatus: 10.1002/PTR.2650070406
171888 - Helleborus cyclophyllus: 10.1016/J.JEP.2020.112954
171897 - Helleborus odorus:
171898 - Helleborus orientalis: 10.1016/J.PHYTOCHEM.2007.11.007
171899 - Helleborus purpurascens:
171901 - Helleborus torquatus: 10.1016/J.PHYTOCHEM.2007.11.007
171901 - Helleborus torquatus: 10.1016/S0031-9422(01)00070-X
171903 - Helleborus viridis: 10.3109/13880209009082817
9606 - Homo sapiens: -
283497 - Iotrochota birotulata: 10.1016/S0039-128X(99)00096-3
82527 - Ipheion uniflorum: 10.1248/CPB.42.1116
305367 - Klasea centauroides: 10.1007/BF00574363
305371 - Klasea erucifolia:
354313 - Klasea marginata: 10.1007/BF00574363
354317 - Klasea procumbens: 10.1007/BF00574363
305379 - Klasea quinquefolia: 10.1007/BF00574363
354320 - Klasea sogdiana: 10.1007/BF00574363
224738 - Lepidothamnus intermedius: 10.1071/CH9721935
699700 - Lepisorus ussuriensis: 10.1016/S0031-9422(99)00056-4
42439 - Limnanthes alba: 10.1515/ZNC-2001-11-1214
28973 - Limnanthes douglasii: 10.1016/S0031-9422(96)00591-2
13824 - Lygodium japonicum: 10.1007/S11418-009-0376-Y
13123 - Lymantria dispar: 10.1002/ARCH.940010404
6523 - Lymnaea stagnalis: 10.1007/BF01959769
7130 - Manduca sexta:
3498 - Morus alba L.: -
253767 - Neocheiropteris palmatopedata: 10.1007/S10600-010-9560-2
85310 - Nezara viridula: 10.1007/BF01946477
144308 - Nierembergia hippomanica: 10.1016/0031-9422(95)00731-8
274375 - Nierembergia linariifolia: 10.1016/0031-9422(95)00731-8
7536 - Oncopeltus fasciatus: 10.1007/BF01946477
292312 - Ourisia caespitosa: 10.1016/S0305-1978(96)00083-X
292327 - Ourisia macrocarpa: 10.1016/S0305-1978(96)00083-X
292330 - Ourisia macrophylla: 10.1016/S0305-1978(96)00083-X
86596 - Palythoa: 10.1007/BF00598556
44685 - Panax japonicus: 10.1002/HLCA.201100085
44924 - Parazoanthus:
49666 - Paris polyphylla:
49666 - Paris polyphylla: 10.1016/J.FITOTE.2008.09.010
221254 - Paris polyphylla var. chinensis:
231488 - Paris quadrifolia: 10.1007/BF00574363
2708930 - Penianthus zenkeri: 10.1016/0031-9422(91)85047-4
265172 - Penstemon venustus: 10.1016/0031-9422(94)00948-S
221785 - Pfaffia glomerata:
451963 - Pfaffia iresinoides:
41506 - Plectocephalus americanus:
90697 - Plenasium banksiifolium: 10.1055/S-0028-1097493
29025 - Podisus maculiventris: 10.1007/BF01946477
38391 - Polypodium fauriei: 10.1248/CPB.17.340
872808 - Polypodium virginianum:
58048 - Polypodium vulgare:
1729754 - Poranopsis discifera: 10.1016/0039-128X(76)90006-4
32101 - Pteridium aquilinum: 10.1016/S0031-9422(00)89065-2
261975 - Pycnogonum litorale: 10.1515/ZNC-1994-5-615
362630 - Rhaponticum carthamoides:
362636 - Rhaponticum integrifolium:
362639 - Rhaponticum lyratum: 10.1007/BF00574363
362646 - Rhaponticum uniflorum:
362646 - Rhaponticum uniflorum: 10.1016/J.PHYTOCHEM.2009.04.008
13249 - Rhodnius prolixus: 10.1007/BF01946477
254022 - Sagina japonica: 10.1007/S10600-010-9729-8
7010 - Schistocerca gregaria: 10.1039/C39810000418
65004 - Serratula tinctoria:
65004 - Serratula tinctoria: 10.1016/S0031-9422(01)00308-9
108380 - Sida spinosa: 10.1016/S0031-9422(03)00021-9
1930050 - Sida szechuensis: 10.14233/AJCHEM.2014.15427
1137874 - Silene banksia: 10.1007/BF00574584
1137874 - Silene banksia: 10.1007/BF00598381
1937749 - Silene brahuica:
39855 - Silene chalcedonica:
39855 - Silene chalcedonica: 10.1007/BF00636590
411984 - Silene fortunei: 10.1007/BF00574584
1080098 - Silene indica:
42037 - Silene italica: 10.1021/NP0205194
37657 - Silene latifolia: 10.1007/BF00574363
39891 - Silene linicola:
39894 - Silene nemoralis: 10.1007/BF00574584
39894 - Silene nemoralis: 10.1021/NP0205194
42038 - Silene nutans:
42039 - Silene otites:
2039599 - Silene spergulifolia: 10.1007/BF02254804
1309628 - Silene supina: 10.1007/BF02254804
39917 - Silene tatarica:
663359 - Silene turkestanica:
335148 - Silene viridiflora:
2082040 - Silene wallichiana:
1850527 - Silene wilfordii: 10.1007/BF00636589
3562 - Spinacia oleracea:
167472 - Stachyurus himalaicus: 10.3390/12030536
85277 - Stachyurus praecox: 10.1248/CPB.17.340
72122 - Tapinella atrotomentosa:
80604 - Tapinella panuoides: 10.1016/S0031-9422(98)00448-8
46220 - Taxus brevifolia: 10.1016/0031-9422(95)00672-9
99806 - Taxus cuspidata:
285590 - Tinospora cordifolia:
100602 - Trichobilharzia ocellata: 10.1016/0166-6851(91)90139-W
49675 - Trillium camschatcense: 10.1248/CPB.55.551
50545 - Trillium erectum: 10.1016/J.PHYTOCHEM.2008.10.019
82499 - Trillium smallii: 10.1248/CPB.17.340
82502 - Trillium tschonoskii: 10.1248/CPB.17.340
87477 - Trisetum flavescens: 10.1016/S0305-1978(97)00087-2
413480 - Vitex canescens:
2364071 - Vitex cymosa: 10.1016/S0367-326X(00)00304-X
413482 - Vitex glabrata: 10.1021/NP50044A041
1899206 - Vitex madiensis:
1365883 - Vitex megapotamica: 10.1002/ARDP.19723051007
548852 - Vitex pinnata: 10.1016/S0031-9422(00)94985-9
2709034 - Vitex thyrsiflora: 10.1016/S0021-9673(01)90442-X
548845 - Vitex tripinnata: 10.1016/S0031-9422(98)00411-7
86683 - Woodwardia orientalis: 10.1248/CPB.41.1803
105401 - Zoanthus: 10.1021/NP010645S
33090 - 珍珠露水草: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	11	AKT1, BCL2, BGLAP, CASP3, CAT, DDC, HSPB1, MTOR, PIK3CA, PTEN, RUNX2
Peripheral membrane protein	3	ACHE, CYP1B1, MTOR
Endosome membrane	1	INSR
Endoplasmic reticulum membrane	4	BCL2, CYP1B1, HSP90B1, MTOR
Nucleus	11	ACHE, AKT1, BCL2, CASP3, HSP90B1, HSPB1, MTOR, PLCZ1, PTEN, RUNX2, USP1
cytosol	13	AKT1, BCL2, CASP3, CAT, DDC, HSP90B1, HSPB1, MTOR, PIK3CA, PLCZ1, PTEN, RUNX2, USP1
dendrite	2	BGLAP, MTOR
phagocytic vesicle	1	MTOR
nucleoplasm	7	AKT1, CASP3, MTOR, PLCZ1, PTEN, RUNX2, USP1
Cell membrane	4	ACHE, AKT1, INSR, TREH
Cytoplasmic side	1	MTOR
lamellipodium	2	AKT1, PIK3CA
Golgi apparatus membrane	1	MTOR
Synapse	1	ACHE
cell cortex	1	AKT1
cell surface	1	ACHE
glutamatergic synapse	2	AKT1, CASP3
Golgi apparatus	1	ACHE
Golgi membrane	2	INS, MTOR
lysosomal membrane	1	MTOR
neuromuscular junction	1	ACHE
neuronal cell body	1	CASP3
postsynapse	1	AKT1
smooth endoplasmic reticulum	1	HSP90B1
Lysosome	2	INSR, MTOR
plasma membrane	6	ACHE, AKT1, INSR, PIK3CA, PTEN, TREH
Membrane	9	ACHE, AKT1, BCL2, CAT, CYP1B1, HSP90B1, INSR, MTOR, TREH
apical plasma membrane	1	PTEN
axon	1	INSR
caveola	1	INSR
extracellular exosome	6	CAT, DDC, HSP90B1, HSPB1, INSR, TREH
Lysosome membrane	1	MTOR
endoplasmic reticulum	2	BCL2, HSP90B1
extracellular space	5	ACHE, BGLAP, HSPB1, IL6, INS
perinuclear region of cytoplasm	4	ACHE, HSP90B1, PIK3CA, PLCZ1
intercalated disc	1	PIK3CA
mitochondrion	3	BCL2, CAT, CYP1B1
protein-containing complex	4	AKT1, BCL2, CAT, HSP90B1
intracellular membrane-bounded organelle	2	CAT, CYP1B1
Microsome membrane	2	CYP1B1, MTOR
postsynaptic density	2	CASP3, PTEN
pronucleus	1	PLCZ1
TORC1 complex	1	MTOR
TORC2 complex	1	MTOR
Single-pass type I membrane protein	1	INSR
Secreted	4	ACHE, BGLAP, IL6, INS
extracellular region	7	ACHE, BGLAP, CAT, HSP90B1, IL6, INS, PTEN
cytoplasmic side of plasma membrane	1	PTEN
Mitochondrion outer membrane	2	BCL2, MTOR
Single-pass membrane protein	1	BCL2
mitochondrial outer membrane	2	BCL2, MTOR
neuronal cell body membrane	1	INSR
mitochondrial matrix	1	CAT
Extracellular side	1	ACHE
transcription regulator complex	1	RUNX2
Nucleus membrane	1	BCL2
Bcl-2 family protein complex	1	BCL2
nuclear membrane	1	BCL2
external side of plasma membrane	1	INSR
dendritic spine	1	PTEN
perikaryon	1	BGLAP
Z disc	1	HSPB1
microtubule cytoskeleton	1	AKT1
nucleolus	1	PLCZ1
axon cytoplasm	1	HSPB1
midbody	1	HSP90B1
cell-cell junction	1	AKT1
vesicle	2	AKT1, BGLAP
Cytoplasm, perinuclear region	1	PLCZ1
pore complex	1	BCL2
Cytoplasm, cytoskeleton, spindle	1	HSPB1
focal adhesion	3	CAT, HSP90B1, HSPB1
spindle	2	AKT1, HSPB1
Peroxisome	1	CAT
basement membrane	1	ACHE
Peroxisome matrix	1	CAT
peroxisomal matrix	1	CAT
peroxisomal membrane	1	CAT
Cell projection, dendritic spine	1	PTEN
Nucleus, PML body	2	MTOR, PTEN
PML body	2	MTOR, PTEN
Mitochondrion intermembrane space	1	AKT1
mitochondrial intermembrane space	1	AKT1
collagen-containing extracellular matrix	1	HSP90B1
Late endosome	1	INSR
receptor complex	1	INSR
Cell projection, neuron projection	1	PTEN
neuron projection	1	PTEN
ciliary basal body	1	AKT1
chromatin	1	RUNX2
cell projection	1	PTEN
cytoskeleton	1	HSPB1
Lipid-anchor, GPI-anchor	2	ACHE, TREH
nuclear envelope	1	MTOR
Endomembrane system	1	MTOR
endosome lumen	1	INS
Cornified envelope	1	HSPB1
Melanosome	1	HSP90B1
side of membrane	2	ACHE, TREH
myelin sheath	1	BCL2
sperm plasma membrane	1	HSP90B1
ficolin-1-rich granule lumen	1	CAT
proteasome complex	1	HSPB1
secretory granule lumen	2	CAT, INS
Golgi lumen	2	BGLAP, INS
endoplasmic reticulum lumen	4	BGLAP, HSP90B1, IL6, INS
phosphatidylinositol 3-kinase complex	1	PIK3CA
phosphatidylinositol 3-kinase complex, class IA	1	PIK3CA
transport vesicle	1	INS
Schmidt-Lanterman incisure	1	PTEN
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
Sarcoplasmic reticulum lumen	1	HSP90B1
synaptic cleft	1	ACHE
death-inducing signaling complex	1	CASP3
dendrite membrane	1	INSR
Cytoplasmic vesicle, phagosome	1	MTOR
endocytic vesicle lumen	1	HSP90B1
catalase complex	1	CAT
sperm head	1	PLCZ1
interleukin-6 receptor complex	1	IL6
insulin receptor complex	1	INSR
endoplasmic reticulum chaperone complex	1	HSP90B1
myelin sheath adaxonal region	1	PTEN
BAD-BCL-2 complex	1	BCL2
[Isoform alpha]: Secreted	1	PTEN
[Isoform H]: Cell membrane	1	ACHE
phosphatidylinositol 3-kinase complex, class IB	1	PIK3CA

文献列表

Susana Tavares Cotrim Ribeiro, Naiara Cássia Gancedo, Arildo José Braz de Oliveira, Regina Aparecida Correia Gonçalves. A comprehensive review of Pfaffia glomerata botany, ethnopharmacology, phytochemistry, biological activities, and biotechnology. Journal of ethnopharmacology. 2024 Jun; 328(?):118003. doi: 10.1016/j.jep.2024.118003. [PMID: 38484957]
Hai-Chao Wang, Ling Li, Jing-Hang Zhang, Zhi-Han Yao, Bao-Ping Pang. MicroRNA miR-7-5p targets MARK2 to control metamorphosis in Galeruca daurica. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2024 Jun; 272(?):110967. doi: 10.1016/j.cbpb.2024.110967. [PMID: 38521445]
Velislava Todorova, Stanislava Ivanova, Dzhevdet Chakarov, Krasimir Kraev, Kalin Ivanov. Ecdysterone and Turkesterone-Compounds with Prominent Potential in Sport and Healthy Nutrition. Nutrients. 2024 May; 16(9):. doi: 10.3390/nu16091382. [PMID: 38732627]
Yu-Xing Zhang, Qiao Tan, Lin Jin, Guo-Qing Li. Molecular characterization of the cytochrome P450 enzyme CYP18A1 in Henosepilachna vigintioctopunctata. Archives of insect biochemistry and physiology. 2024 Apr; 115(4):e22111. doi: 10.1002/arch.22111. [PMID: 38628055]
Haihui Xing, Guohua Chen, Faisal Raza, Hajra Zafar, Lei Xing, Qiaoyun Li, Ran Li, Shanshan Xu, Dan Chen. The Protective Effects of Ecdysterone on Cognitive Impairment through Regulating Akt/GSK-3β/Nrf2 Signaling Pathway and Oxidative Stress in Cognitive Mice Model and Aβ-Induced Cell Neurotoxicity. Frontiers in bioscience (Landmark edition). 2024 Mar; 29(3):109. doi: 10.31083/j.fbl2903109. [PMID: 38538266]
Yong Wang, Benjamin Buer, Cynthia L Goodman, David Kang, Tamra Reall, Susanne Dohn, Joseph Ringbauer, Yaofa Li, Sven Geibel, David Stanley. Indomethacin and 20-hydroxyecdysone influence protein expression in a Spodoptera frugiperda nervous system cell line. Archives of insect biochemistry and physiology. 2024 Feb; 115(2):e22089. doi: 10.1002/arch.22089. [PMID: 38409869]
Hugo Alarie, Nadia Côté, Luc Gaudreau, Magali Houde, Pedro A Segura. Are 20-hydroxyecdysone and related genes potential biomarkers of sublethal exposure to lipid-altering contaminants?. Environmental science and pollution research international. 2023 Dec; 30(60):126104-126115. doi: 10.1007/s11356-023-31087-2. [PMID: 38010540]
Kou Wang, Wen Liu, Xiao-Ping Wang. Dpp-mediated TGF-β signaling regulates vitellogenesis through 20-hydroxyecdysone signaling in the cabbage beetle, Colaphellus bowringi. Pesticide biochemistry and physiology. 2023 Dec; 197(?):105706. doi: 10.1016/j.pestbp.2023.105706. [PMID: 38072559]
Xinxin Gao, Jihong Zhang, Qilian Qin, Peipei Wu, Huan Zhang, Qian Meng. Metabolic changes during larval-pupal metamorphosis of Helicoverpa armigera. Insect science. 2023 Dec; 30(6):1663-1676. doi: 10.1111/1744-7917.13201. [PMID: 37200210]
Di Wen, Zhi Chen, Jiamin Wen, Qiangqiang Jia. Sterol Regulation of Development and 20-Hydroxyecdysone Biosynthetic and Signaling Genes in Drosophila melanogaster. Cells. 2023 Jun; 12(13):. doi: 10.3390/cells12131739. [PMID: 37443773]
Sheng-Yu Zhang, Han Gao, Ankarjan Askar, Xing-Peng Li, Guo-Cai Zhang, Tian-Zhong Jing, Hang Zou, Hao Guan, Yun-He Zhao, Chuan-Shan Zou. Steroid hormone 20-hydroxyecdysone disturbs fat body lipid metabolism and negatively regulates gluconeogenesis in Hyphantria cunea larvae. Insect science. 2023 Jun; 30(3):771-788. doi: 10.1111/1744-7917.13130. [PMID: 36342157]
Xue-Li Hou, Yu-Qi Gao, Jing-Hui Yang, Han-Wu Liu, Meng-Meng Bai, Zhen-Hai Wu, Chun-Huan Li, Jun-Mian Tian, Jin-Ming Gao. Phytoecdysteroids from Dianthus superbus L.: Structures and anti-neuroinflammatory evaluation. Phytochemistry. 2023 May; 212(?):113710. doi: 10.1016/j.phytochem.2023.113710. [PMID: 37178942]
Yongan Tan, Liubin Xiao, Jing Zhao, Jieyu Zhang, Sheraz Ahmad, Dejin Xu, Guangchun Xu, Linquan Ge. Adenosine Monophosphate-Activated Protein Kinase (AMPK) Phosphorylation Is Required for 20-Hydroxyecdysone Regulates Ecdysis in Apolygus lucorum. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24108587. [PMID: 37239932]
Tianran Li, Yinhao Ye, Peng Wu, Rengang Luo, Hongyu Zhang, Weiwei Zheng. Proteasome β3 subunit (PSMB3) controls female reproduction by promoting ecdysteroidogenesis during sexual maturation in Bactrocera dorsalis. Insect biochemistry and molecular biology. 2023 May; 157(?):103959. doi: 10.1016/j.ibmb.2023.103959. [PMID: 37172766]
Waly Dioh, Cendrine Tourette, Susanna Del Signore, Louiza Daudigny, Philippe Dupont, Christine Balducci, Pierre J Dilda, René Lafont, Stanislas Veillet. A Phase 1 study for safety and pharmacokinetics of BIO101 (20-hydroxyecdysone) in healthy young and older adults. Journal of cachexia, sarcopenia and muscle. 2023 Apr; ?(?):. doi: 10.1002/jcsm.13195. [PMID: 37057316]
Ruonan Zhang, Xue Chen, Yuan Wang, Xu Bai, Qiong Yang, Yangjin Zhong, Xiao-Qiang Yu, Fengliang Jin, Wanying Yang. BmMD-2A responds to 20-hydroxyecdysone and regulates Bombyx mori silkworm innate immunity in larva-to-pupa metamorphosis. Insect science. 2023 Apr; 30(2):411-424. doi: 10.1111/1744-7917.13097. [PMID: 35871306]
Siriporn Sripinyowanich, Sahanat Petchsri, Pumipat Tongyoo, Taek-Kyun Lee, Sukchan Lee, Won Kyong Cho. Comparative Transcriptomic Analysis of Genes in the 20-Hydroxyecdysone Biosynthesis in the Fern Microsorum scolopendria towards Challenges with Foliar Application of Chitosan. International journal of molecular sciences. 2023 Jan; 24(3):. doi: 10.3390/ijms24032397. [PMID: 36768717]
Jingnan Hu, Yu Feng, Baolin Li, Fengxia Wang, Qi Qian, Wei Tian, Liying Niu, Xinguo Wang. Identification of quality markers for Cyanotis arachnoidea and analysis of its physiological mechanism based on chemical pattern recognition, network pharmacology, and experimental validation. PeerJ. 2023; 11(?):e15948. doi: 10.7717/peerj.15948. [PMID: 37719108]
Weiwei Zheng, Fangyu Wu, Yinhao Ye, Tianran Li, Zhenyu Zhang, Hongyu Zhang. Small GTPase Rab40C is upregulated by 20-hydroxyecdysone and insulin pathways to regulate ovarian development and fecundity. Insect science. 2022 Dec; 29(6):1583-1600. doi: 10.1111/1744-7917.13026. [PMID: 35349758]
Feng Chen, Xiao-Qing Zhang, Jian-Jian Wu, Lin Jin, Guo-Qing Li. Requirement of Myoglianin for metamorphosis in the beetle Henosepilachna vigintioctopunctata. Insect molecular biology. 2022 12; 31(6):671-685. doi: 10.1111/imb.12795. [PMID: 35661293]
Blaise Cedric Kamdoum, Ingrid Simo, Steven Collins Njonte Wouamba, Brice Mariscal Tchatat Tali, Bathelemy Ngameni, Ghislain Wabo Fotso, Pantaléon Ambassa, Fekam Boyom Fabrice, Bruno Ndjakou Lenta, Norbert Sewald, Bonaventure Tchaleu Ngadjui. Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity. Natural product research. 2022 Oct; 36(20):5311-5318. doi: 10.1080/14786419.2021.1937156. [PMID: 34121522]
Jingjing Li, Letong Yin, Jingxiu Bi, David Stanley, Qili Feng, Qisheng Song. The TGF-β Receptor Gene Saxophone Influences Larval-Pupal-Adult Development in Tribolium castaneum. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27186017. [PMID: 36144752]
Qiang Zhang, Wei Dou, Clauvis Nji Tizi Taning, Shan-Shan Yu, Guo-Rui Yuan, Feng Shang, Guy Smagghe, Jin-Jun Wang. miR-309a is a regulator of ovarian development in the oriental fruit fly Bactrocera dorsalis. PLoS genetics. 2022 09; 18(9):e1010411. doi: 10.1371/journal.pgen.1010411. [PMID: 36112661]
Zhi-Xiong Zhou, Wei Dou, Chuan-Ren Li, Jin-Jun Wang. CYP314A1-dependent 20-hydroxyecdysone biosynthesis is involved in regulating the development of pupal diapause and energy metabolism in the Chinese citrus fruit fly, Bactrocera minax. Pest management science. 2022 Aug; 78(8):3384-3393. doi: 10.1002/ps.6966. [PMID: 35514223]
Ugiloy Yusupova, Durbek Usmanov, Aziz Azamatov, Nurmurod Ramazonov, Jumadilla Rejepov. Phytochemical constituents and biological activities of Dianthus helenae Vved., growing in Uzbekistan. Natural product research. 2022 Jul; 36(13):3480-3484. doi: 10.1080/14786419.2020.1862834. [PMID: 33342285]
Emmanuelle Claude, Rene Lafont, Robert S Plumb, Ian D Wilson. High performance Reversed-Phase Thin-Layer Chromatography-Desorption electrospray ionisation - time of flight high resolution mass spectrometric detection and imaging (HPTLC/DESI/ToFMS) of phytoecdysteroids. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jun; 1200(?):123265. doi: 10.1016/j.jchromb.2022.123265. [PMID: 35526348]
Jun-Li Du, Feng Chen, Jian-Jian Wu, Lin Jin, Guo-Qing Li. Smad on X is vital for larval-pupal transition in a herbivorous ladybird beetle. Journal of insect physiology. 2022 May; 139(?):104387. doi: 10.1016/j.jinsphys.2022.104387. [PMID: 35367434]
Artyom Y Baev, Oksana S Charishnikova, Feruzbek A Khasanov, Kamila S Nebesnaya, Albert R Makhmudov, Mannona T Rakhmedova, Zainab A Khushbaktova, Vladimir N Syrov, Yuliya V Levitskaya. Ecdysterone prevents negative effect of acute immobilization stress on energy metabolism of rat liver mitochondria. The Journal of steroid biochemistry and molecular biology. 2022 05; 219(?):106066. doi: 10.1016/j.jsbmb.2022.106066. [PMID: 35104603]
Li Wang, Shen Li, Hongda Cai, Xiaohu Liu, Tongtong Feng, Xiuhua Zhao. Preparation and characterisation of ecdysterone/hydroxypropyl-Β-cyclodextrin inclusion complex with enhanced oral and transdermal bioavailability. Journal of microencapsulation. 2022 Mar; 39(2):145-155. doi: 10.1080/02652048.2022.2056251. [PMID: 35311602]
Yanpeng Chang, Bo Zhang, Mengfang Du, Zichen Geng, Jizhen Wei, Ruobing Guan, Shiheng An, Wenli Zhao. The vital hormone 20-hydroxyecdysone controls ATP production by upregulating binding of trehalase 1 with ATP synthase subunit α in Helicoverpa armigera. The Journal of biological chemistry. 2022 02; 298(2):101565. doi: 10.1016/j.jbc.2022.101565. [PMID: 34999119]
Lang You, Zhiqian Li, Zhongjie Zhang, Bo Hu, Ye Yu, Fangying Yang, Anjiang Tan. Two dehydroecdysone reductases act as fat body-specific 20E catalyzers in Bombyx mori. Insect science. 2022 Feb; 29(1):100-110. doi: 10.1111/1744-7917.12928. [PMID: 34018323]
Chunyan Fang, Yaqun Xin, Tao Sun, Antónia Monteiro, Zhanfeng Ye, Fangyin Dai, Cheng Lu, Xiaoling Tong. The Hox gene Antennapedia is essential for wing development in insects. Development (Cambridge, England). 2022 01; 149(2):. doi: 10.1242/dev.199841. [PMID: 35088829]
Abdurakhim Toychiev, Fikrat Kerimov, Jannat Islamova, Mukambar Shaislamova, Murod Mirzakhmedov, Nikolay Davis, Vladimir Syrov, Svetlana Osipova. Antiprotozoal effect of steroid hormone 20-hydroxyecdysone in giardiosis patients. Annals of parasitology. 2022; 68(3):605-615. doi: 10.17420/ap6803.467. [PMID: 36617399]
Baoyu Fu, Rui Ma, Fangbing Liu, Xuenan Chen, Xiaoyu Teng, Pengdi Yang, Jianzeng Liu, Daqing Zhao, Liwei Sun. Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway. Frontiers in endocrinology. 2022; 13(?):964069. doi: 10.3389/fendo.2022.964069. [PMID: 36017314]
Kui Hu, Baobao Fu, Chuchu Wang, Jianqi Liu, Yingying Tang, Wendan Zhang, Jun Zhu, Yao Li, Qinjian Pan, Fang Liu. The role of 20E biosynthesis relative gene Shadow in the reproduction of the predatory mirid bug, Cyrtorhinus lividipennis (Hemiptera: Miridae). Archives of insect biochemistry and physiology. 2022 Jan; 109(1):e21854. doi: 10.1002/arch.21854. [PMID: 34783381]
Yanghua Tang, Yafeng Mo, Dawei Xin, Zhenfei Xiong, Linru Zeng, Gan Luo, Yanguang Cao. Regulation of osteoblast autophagy based on PI3K/AKT/mTOR signaling pathway study on the effect of β-ecdysterone on fracture healing. Journal of orthopaedic surgery and research. 2021 Dec; 16(1):719. doi: 10.1186/s13018-021-02862-z. [PMID: 34924000]
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Li Yang, Thomas Friedemann, Jian Pan. Ecdysterone Attenuates the Development of Radiation-Induced Oral Mucositis in Rats at Early Stage. Radiation research. 2021 10; 196(4):366-374. doi: 10.1667/rade-21-00042.1. [PMID: 34237140]
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Safa Khelifi, Khadija Saad, Ariadni Vonaparti, Souhila Mahieddine, Sofia Salama, Amal Saleh, Maryam Al-Mohannadi, Hussain Al-Thaiban, Arjen Lommen, Peter Horvatovich, Alka Beotra, Wadha Abushareeda, Mohammed Al Maadheed, Costas Georgakopoulos. Ultra-fast retroactive processing by MetAlign of liquid chromatography/high-resolution full-scan Orbitrap mass spectrometry data in WADA Human Urine Sample Monitoring Program. Rapid communications in mass spectrometry : RCM. 2021 Sep; 35(17):e9141. doi: 10.1002/rcm.9141. [PMID: 34106497]
Christine Balducci, Laurence Dinan, Louis Guibout, Anne-Sophie Foucault, Christel Carbonne, Jean-Denis Durand, Cédric Caradeuc, Gildas Bertho, Jean-Pierre Girault, René Lafont. The complex metabolism of poststerone in male rats. The Journal of steroid biochemistry and molecular biology. 2021 09; 212(?):105897. doi: 10.1016/j.jsbmb.2021.105897. [PMID: 33862260]
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Peirong Li, Xinru Li, Wei Wang, Xiaoling Tan, Xiaoqi Wang, Xueqing Yang. Transcriptional identification of differentially expressed genes during the prepupal-pupal transition in the oriental armyworm, Mythimna separata (Walker) (Lepidoptera: Noctuidae). Bulletin of entomological research. 2021 Aug; 111(4):485-498. doi: 10.1017/s0007485321000171. [PMID: 33745467]
Wei-Nan Kang, Bing-Yao Wang, Kai-Yun Fu, Wen-Chao Guo, Lin Jin, Guo-Qing Li. The Leptinotarsa forkhead transcription factor O exerts a key function during larval-pupal-adult transition. Journal of insect physiology. 2021 07; 132(?):104266. doi: 10.1016/j.jinsphys.2021.104266. [PMID: 34126099]
Junzhu Han, Jianzhong Guan, Xunbing Zhu. β-Ecdysone attenuates cartilage damage in a mouse model of collagenase-induced osteoarthritis via mediating FOXO1/ADAMTS-4/5 signaling axis. Histology and histopathology. 2021 Jul; 36(7):785-794. doi: 10.14670/hh-18-341. [PMID: 33876419]
Souhail Kraiem, Maneera Y Al-Jaber, Hana Al-Mohammed, Afnan S Al-Menhali, Noora Al-Thani, Murad Helaleh, Waseem Samsam, Soufiane Touil, Alka Beotra, Costas Georgakopoulas, Sondes Bouabdallah, Vidya Mohamed-Ali, Mohammed Al Maadheed. Analytical strategy for the detection of ecdysterone and its metabolites in vivo in uPA(+/+)-SCID mice with humanized liver, human urine samples, and estimation of prevalence of its use in anti-doping samples. Drug testing and analysis. 2021 Jul; 13(7):1341-1353. doi: 10.1002/dta.3032. [PMID: 33759363]
P V P Nascimento, F Almeida-Oliveira, A Macedo-Silva, P Ausina, C Motinha, M Sola-Penna, D Majerowicz. Gene annotation of nuclear receptor superfamily genes in the kissing bug Rhodnius prolixus and the effects of 20-hydroxyecdysone on lipid metabolism. Insect molecular biology. 2021 06; 30(3):297-314. doi: 10.1111/imb.12696. [PMID: 33455040]
C-H Shen, Q-Y Xu, K-Y Fu, W-C Guo, L Jin, G-Q Li. Ecdysis triggering hormone is essential for larva-pupa-adult transformation in Leptinotarsa decemlineata. Insect molecular biology. 2021 06; 30(3):241-252. doi: 10.1111/imb.12691. [PMID: 33368728]
Magdalena J M Marschall, Robert Ringseis, Denise K Gessner, Sarah M Grundmann, Erika Most, Gaiping Wen, Garima Maheshwari, Holger Zorn, Klaus Eder. Effect of Ecdysterone on the Hepatic Transcriptome and Lipid Metabolism in Lean and Obese Zucker Rats. International journal of molecular sciences. 2021 May; 22(10):. doi: 10.3390/ijms22105241. [PMID: 34063487]
Mathilde Latil, Serge Camelo, Stanislas Veillet, René Lafont, Pierre J Dilda. Developing new drugs that activate the protective arm of the renin-angiotensin system as a potential treatment for respiratory failure in COVID-19 patients. Drug discovery today. 2021 05; 26(5):1311-1318. doi: 10.1016/j.drudis.2021.02.010. [PMID: 33609783]
Yu-Qin Di, Xiao-Lin Han, Xin-Le Kang, Di Wang, Cai-Hua Chen, Jin-Xing Wang, Xiao-Fan Zhao. Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis. Autophagy. 2021 05; 17(5):1170-1192. doi: 10.1080/15548627.2020.1752497. [PMID: 32324083]
Juan Zhu, Yan-Rong Chen, Tao Geng, Shun-Ming Tang, Qiao-Ling Zhao, Xing-Jia Shen. A 14-amino acids deletion in BmShadow results to non-moult on the 2nd instar in the bivoltine silkworm, Bombyx mori. Gene. 2021 Apr; 777(?):145450. doi: 10.1016/j.gene.2021.145450. [PMID: 33516793]
Hadjer Agoun, Nesrine Semiane, Aicha Mallek, Zineb Bellahreche, Soumia Hammadi, Maha Madjerab, Mohamed Abdlalli, Ali Khalkhal, Yasmina Dahmani. High-carbohydrate diet-induced metabolic disorders in Gerbillus tarabuli (a new model of non-alcoholic fatty-liver disease). Protective effects of 20-hydroxyecdysone. Archives of physiology and biochemistry. 2021 Apr; 127(2):127-135. doi: 10.1080/13813455.2019.1621350. [PMID: 31190566]
Caihong Ji, Nan Zhang, Heng Jiang, Xiangkun Meng, Huichen Ge, Xuemei Yang, Xin Xu, Kun Qian, Yoonseong Park, Yang Zheng, Jianjun Wang. 20-hydroxyecdysone regulates expression of methioninesulfoxide reductases through transcription factor FOXO in the red flour beetle, Tribolium castaneum. Insect biochemistry and molecular biology. 2021 04; 131(?):103546. doi: 10.1016/j.ibmb.2021.103546. [PMID: 33548484]
Yong-An Tan, Xu-Dong Zhao, Hou-Jun Sun, Jing Zhao, Liu-Bin Xiao, De-Jun Hao, Yi-Pin Jiang. Phospholipase C gamma (PLCγ) regulates soluble trehalase in the 20E-induced fecundity of Apolygus lucorum. Insect science. 2021 Apr; 28(2):430-444. doi: 10.1111/1744-7917.12772. [PMID: 32108427]
Rodrigo Rodrigues Franco, Letícia de Almeida Takata, Kristhiano Chagas, Allisson Benatti Justino, André Lopes Saraiva, Luiz Ricardo Goulart, Veridiana de Melo Rodrigues Ávila, Wagner Campos Otoni, Foued Salmen Espindola, Cássia Regina da Silva. A 20-hydroxyecdysone-enriched fraction from Pfaffia glomerata (Spreng.) pedersen roots alleviates stress, anxiety, and depression in mice. Journal of ethnopharmacology. 2021 Mar; 267(?):113599. doi: 10.1016/j.jep.2020.113599. [PMID: 33220360]
Wanna Zhang, Long Ma, Xiangya Liu, Yingchuan Peng, Gemei Liang, Haijun Xiao. Dissecting the roles of FTZ-F1 in larval molting and pupation, and the sublethal effects of methoxyfenozide on Helicoverpa armigera. Pest management science. 2021 Mar; 77(3):1328-1338. doi: 10.1002/ps.6146. [PMID: 33078511]
Zidan Zhu, Chunmei Tong, Binbin Qiu, Hongguang Yang, Jiahui Xu, Sichun Zheng, Qisheng Song, Qili Feng, Huimin Deng. 20E-mediated regulation of BmKr-h1 by BmKRP promotes oocyte maturation. BMC biology. 2021 02; 19(1):39. doi: 10.1186/s12915-021-00952-2. [PMID: 33632227]
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