PHENYLACETIC ACID (BioDeep_00000229664)

Main id: BioDeep_00000400112

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2-phenylacetic acid

化学式: C8H8O2 (136.0524268)
中文名称: 苯乙酸-羧基-14C, 苯乙酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CC(=O)O
InChI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)

描述信息

D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

2-phenylacetic acid; PHENYLACETIC ACID



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

210 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Peiqi Zhang, Jose Huguet-Tapia, Zhao Peng, Sanzhen Liu, Ken Obasa, Anna K Block, Frank F White. Genome analysis and hyphal movement characterization of the hitchhiker endohyphal Enterobacter sp. from Rhizoctonia solani. Applied and environmental microbiology. 2024 Mar; 90(3):e0224523. doi: 10.1128/aem.02245-23. [PMID: 38319098]
  • Xinchun Li, HuiHui Hou, He Liu, Hancheng Wang, Liuti Cai, Mengnan An, Chong Zhang, Yuanhua Wu. Identification of 3-Methoxyphenylacetic Acid as a Phytotoxin, Produced by Rhizoctonia solani AG-3 TB. Molecules (Basel, Switzerland). 2023 Jan; 28(2):. doi: 10.3390/molecules28020790. [PMID: 36677848]
  • Xu Pang, Guo-Wei Cai, Meng-Yan Wang, Xiu-Fei Chen, Wen-Ni He, Wu-Li Zhao, Tao Zhang, Li-Yan Yu. Metabolites from the plant endophytic fungus Penicillium sp. CPCC 401423 and their cytotoxic activity against MIA PaCa-2 cells. Journal of Asian natural products research. 2022 Aug; ?(?):1-12. doi: 10.1080/10286020.2022.2104719. [PMID: 35920176]
  • Rifaat Safadi, Robert S Rahimi, Dominique Thabut, Jasmohan S Bajaj, Kalyan Ram Bhamidimarri, Nikolaos Pyrsopoulos, Amy Potthoff, Stan Bukofzer, Laurene Wang, Khurram Jamil, Krishna R Devarakonda. Pharmacokinetics/pharmacodynamics of L-ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes. Clinical and translational science. 2022 06; 15(6):1449-1459. doi: 10.1111/cts.13257. [PMID: 35238476]
  • Xiaofeng Wang, Regis A Vilchez. Population Pharmacokinetic Analysis to Assist Dose Selection of the L-Ornithine Salt of Phenylacetic Acid. Clinical pharmacokinetics. 2022 04; 61(4):515-526. doi: 10.1007/s40262-021-01075-1. [PMID: 34786649]
  • Hang Pan, Yang Xiao, Ailin Xie, Zhu Li, Haixia Ding, XiaoJu Yuan, Ran Sun, Qiuju Peng. The antibacterial mechanism of phenylacetic acid isolated from Bacillus megaterium L2 against Agrobacterium tumefaciens. PeerJ. 2022; 10(?):e14304. doi: 10.7717/peerj.14304. [PMID: 36389424]
  • Xiaofeng Wang, Jack Tseng, Carmen Mak, Nagaraju Poola, Regis A Vilchez. Exposures of Phenylacetic Acid and Phenylacetylglutamine Across Different Subpopulations and Correlation with Adverse Events. Clinical pharmacokinetics. 2021 12; 60(12):1557-1567. doi: 10.1007/s40262-021-01047-5. [PMID: 34125423]
  • Bartosz Jablonski, Andrzej Bajguz, Joanna Bocian, Waclaw Orczyk, Anna Nadolska-Orczyk. Genotype-Dependent Effect of Silencing of TaCKX1 and TaCKX2 on Phytohormone Crosstalk and Yield-Related Traits in Wheat. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111494. [PMID: 34768924]
  • Takahiro Mori, Kiyofumi Wanibuchi, Hiroyuki Morita, Ikuro Abe. Amide Bond Formation Using 4-Coumarate: CoA Ligase from Arabidopsis thaliana. Chemical & pharmaceutical bulletin. 2021 Aug; 69(8):717-720. doi: 10.1248/cpb.c21-00404. [PMID: 34053981]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Nicola Longo, George A Diaz, Uta Lichter-Konecki, Andreas Schulze, Michal Inbar-Feigenberg, Robert L Conway, Allison A Bannick, Shawn E McCandless, Roberto Zori, Bryan Hainline, Nicholas Ah Mew, Colleen Canavan, Thomas Vescio, Teresa Kok, Marty H Porter, Susan A Berry. Glycerol phenylbutyrate efficacy and safety from an open label study in pediatric patients under 2 months of age with urea cycle disorders. Molecular genetics and metabolism. 2021 01; 132(1):19-26. doi: 10.1016/j.ymgme.2020.12.002. [PMID: 33388234]
  • Somjai Teanphonkrang, Wipa Suginta, Jeerus Sucharitakul, Tamo Fukamizo, Pimchai Chaiyen, Albert Schulte. An electrochemical method for detecting the biomarker 4-HPA by allosteric activation of Acinetobacterbaumannii reductase C1 subunit. The Journal of biological chemistry. 2021 Jan; 296(?):100467. doi: 10.1016/j.jbc.2021.100467. [PMID: 33639166]
  • Yuki Aoi, Hayao Hira, Yuya Hayakawa, Hongquan Liu, Kosuke Fukui, Xinhua Dai, Keita Tanaka, Ken-Ichiro Hayashi, Yunde Zhao, Hiroyuki Kasahara. UDP-glucosyltransferase UGT84B1 regulates the levels of indole-3-acetic acid and phenylacetic acid in Arabidopsis. Biochemical and biophysical research communications. 2020 11; 532(2):244-250. doi: 10.1016/j.bbrc.2020.08.026. [PMID: 32868079]
  • Chen Wang, Xiaojing Wang, Liwen Zhang, Qun Yue, Qingpei Liu, Ya-Ming Xu, A A Leslie Gunatilaka, Xiaoyi Wei, Yuquan Xu, István Molnár. Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases. Journal of the American Chemical Society. 2020 10; 142(40):17093-17104. doi: 10.1021/jacs.0c07050. [PMID: 32833442]
  • Rupesh Raina, Jirair K Bedoyan, Uta Lichter-Konecki, Philippe Jouvet, Stefano Picca, Nicholas Ah Mew, Marcel C Machado, Ronith Chakraborty, Meghana Vemuganti, Manpreet K Grewal, Timothy Bunchman, Sidharth Kumar Sethi, Vinod Krishnappa, Mignon McCulloch, Khalid Alhasan, Arvind Bagga, Rajit K Basu, Franz Schaefer, Guido Filler, Bradley A Warady. Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy. Nature reviews. Nephrology. 2020 08; 16(8):471-482. doi: 10.1038/s41581-020-0267-8. [PMID: 32269302]
  • Erman Popowski, Benjamin Kohl, Tobias Schneider, Joachim Jankowski, Gundula Schulze-Tanzil. Uremic Toxins and Ciprofloxacin Affect Human Tenocytes In Vitro. International journal of molecular sciences. 2020 Jun; 21(12):. doi: 10.3390/ijms21124241. [PMID: 32545914]
  • Yuki Aoi, Akira Oikawa, Ryosuke Sasaki, Jirong Huang, Ken-Ichiro Hayashi, Hiroyuki Kasahara. Arogenate dehydratases can modulate the levels of phenylacetic acid in Arabidopsis. Biochemical and biophysical research communications. 2020 03; 524(1):83-88. doi: 10.1016/j.bbrc.2020.01.041. [PMID: 31980164]
  • Yuki Aoi, Keita Tanaka, Sam David Cook, Ken-Ichiro Hayashi, Hiroyuki Kasahara. GH3 Auxin-Amido Synthetases Alter the Ratio of Indole-3-Acetic Acid and Phenylacetic Acid in Arabidopsis. Plant & cell physiology. 2020 Mar; 61(3):596-605. doi: 10.1093/pcp/pcz223. [PMID: 31808940]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Marieke Sternkopf, Sven Thoröe-Boveleth, Tobias Beck, Kirsten Oleschko, Ansgar Erlenkötter, Ulrich Tschulena, Sonja Steppan, Thimoteus Speer, Claudia Goettsch, Vera Jankowski, Joachim Jankowski, Heidi Noels. A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients. Toxins. 2019 07; 11(7):. doi: 10.3390/toxins11070389. [PMID: 31277311]
  • Akihiro Oochi, Jakub Hajny, Kosuke Fukui, Yukio Nakao, Michelle Gallei, Mussa Quareshy, Koji Takahashi, Toshinori Kinoshita, Sigurd Ramans Harborough, Stefan Kepinski, Hiroyuki Kasahara, Richard Napier, Jiří Friml, Ken-Ichiro Hayashi. Pinstatic Acid Promotes Auxin Transport by Inhibiting PIN Internalization. Plant physiology. 2019 06; 180(2):1152-1165. doi: 10.1104/pp.19.00201. [PMID: 30936248]
  • Sam D Cook. An Historical Review of Phenylacetic Acid. Plant & cell physiology. 2019 Feb; 60(2):243-254. doi: 10.1093/pcp/pcz004. [PMID: 30649529]
  • Kiyoshi Mashiguchi, Hiroshi Hisano, Noriko Takeda-Kamiya, Yumiko Takebayashi, Tohru Ariizumi, Yangbin Gao, Hiroshi Ezura, Kazuhiro Sato, Yunde Zhao, Ken-Ichiro Hayashi, Hiroyuki Kasahara. Agrobacterium tumefaciens Enhances Biosynthesis of Two Distinct Auxins in the Formation of Crown Galls. Plant & cell physiology. 2019 Jan; 60(1):29-37. doi: 10.1093/pcp/pcy182. [PMID: 30169882]
  • Feiyu Huang, Xiaoyu Li, Jian Guo, Hai Feng, Fei Yang. Aromatic hydrocarbon compound degradation of phenylacetic acid by indigenous bacterial Sphingopyxis isolated from Lake Taihu. Journal of toxicology and environmental health. Part A. 2019; 82(22):1164-1171. doi: 10.1080/15287394.2019.1703510. [PMID: 31833448]
  • Kai-Hong Guo, Kun-Hua Lu, Yi-Chun Yeh. Cell-Based Biosensor with Dual Signal Outputs for Simultaneous Quantification of Phenylacetic Acid and Phenylethylamine. ACS synthetic biology. 2018 12; 7(12):2790-2795. doi: 10.1021/acssynbio.8b00416. [PMID: 30418753]
  • Susan A Berry, Jerry Vockley, Alexander A Vinks, Min Dong, George A Diaz, Shawn E McCandless, Wendy E Smith, Cary O Harding, Roberto Zori, Can Ficicioglu, Uta Lichter-Konecki, Renee Perdok, Beth Robinson, Robert J Holt, Nicola Longo. Pharmacokinetics of glycerol phenylbutyrate in pediatric patients 2 months to 2 years of age with urea cycle disorders. Molecular genetics and metabolism. 2018 11; 125(3):251-257. doi: 10.1016/j.ymgme.2018.09.001. [PMID: 30217721]
  • Isabel Gutiérrez-Díaz, Tania Fernández-Navarro, Nuria Salazar, Begoña Bartolomé, M Victoria Moreno-Arribas, Patricia López, Ana Suárez, Clara G de Los Reyes-Gavilán, Miguel Gueimonde, Sonia González. Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status?. Journal of agricultural and food chemistry. 2018 Oct; 66(40):10438-10446. doi: 10.1021/acs.jafc.8b04102. [PMID: 30227707]
  • Chengcheng Xiang, Shidai Jin, Juan Zhang, Minjian Chen, Yankai Xia, Yongqian Shu, Renhua Guo. Cortisol, cortisone, and 4-methoxyphenylacetic acid as potential plasma biomarkers for early detection of non-small cell lung cancer. The International journal of biological markers. 2018 Aug; 33(3):314-320. doi: 10.1177/1724600818778754. [PMID: 29896992]
  • Sumanto Haldar, Sze Han Lee, Jun Jie Tan, Siok Ching Chia, Christiani Jeyakumar Henry, Eric Chun Yong Chan. Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study. Nutrients. 2018 Jul; 10(7):. doi: 10.3390/nu10070934. [PMID: 30037045]
  • Brijesh K Gupta, Khirod K Sahoo, Ajit Ghosh, Amit K Tripathi, Khalid Anwar, Priyanka Das, Anil K Singh, Ashwani Pareek, Sudhir K Sopory, Sneh L Singla-Pareek. Manipulation of glyoxalase pathway confers tolerance to multiple stresses in rice. Plant, cell & environment. 2018 05; 41(5):1186-1200. doi: 10.1111/pce.12968. [PMID: 28425127]
  • Yael Wilnai, Yair J Blumenfeld, Kristina Cusmano, Susan R Hintz, Deborah Alcorn, William E Benitz, William E Berquist, Jonathan A Bernstein, Ricardo O Castillo, Waldo Concepcion, Tina M Cowan, Kenneth L Cox, Deirdre J Lyell, Carlos O Esquivel, Margaret Homeyer, Louanne Hudgins, Melissa Hurwitz, Jonathan P Palma, Susan Schelley, Vishnu Priya Akula, Marshall L Summar, Gregory M Enns. Prenatal treatment of ornithine transcarbamylase deficiency. Molecular genetics and metabolism. 2018 03; 123(3):297-300. doi: 10.1016/j.ymgme.2018.01.004. [PMID: 29396029]
  • G van Straten, M G M de Sain-van der Velden, I M van Geijlswijk, R P Favier, S J Mesu, N E Holwerda-Loof, M van der Ham, H Fieten, J Rothuizen, B Spee, N M Verhoeven-Duif. Saline is as effective as nitrogen scavengers for treatment of hyperammonemia. Scientific reports. 2017 10; 7(1):13112. doi: 10.1038/s41598-017-12686-9. [PMID: 29030642]
  • Michael S Machas, Rebekah McKenna, David R Nielsen. Expanding Upon Styrene Biosynthesis to Engineer a Novel Route to 2-Phenylethanol. Biotechnology journal. 2017 Oct; 12(10):. doi: 10.1002/biot.201700310. [PMID: 28799719]
  • Qi Xu, Monica Langley, Anumantha G Kanthasamy, Manju B Reddy. Epigallocatechin Gallate Has a Neurorescue Effect in a Mouse Model of Parkinson Disease. The Journal of nutrition. 2017 10; 147(10):1926-1931. doi: 10.3945/jn.117.255034. [PMID: 28835392]
  • Gabriela L Müller, Marisel Tuttobene, Matías Altilio, Maitena Martínez Amezaga, Meaghan Nguyen, Pamela Cribb, Larisa E Cybulski, María Soledad Ramírez, Silvia Altabe, María Alejandra Mussi. Light Modulates Metabolic Pathways and Other Novel Physiological Traits in the Human Pathogen Acinetobacter baumannii. Journal of bacteriology. 2017 05; 199(10):. doi: 10.1128/jb.00011-17. [PMID: 28289081]
  • Anne H O'Donnell-Luria, Alexander P Lin, Sai K Merugumala, Frances Rohr, Susan E Waisbren, Rebecca Lynch, Vatche Tchekmedyian, Aaron D Goldberg, Andrew Bellinger, J Ricardo McFaline-Figueroa, Tracey Simon, Esteban F Gershanik, Bruce D Levy, David E Cohen, Martin A Samuels, Gerard T Berry, Natasha Y Frank. Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma. Molecular genetics and metabolism. 2017 05; 121(1):9-15. doi: 10.1016/j.ymgme.2017.03.003. [PMID: 28408159]
  • Dennis J Orton, Jessica L Gifford, Isolde Seiden-Long, Aneal Khan, Lawrence de Koning. Critically High Plasma Ammonia in an Adolescent Girl. Clinical chemistry. 2016 12; 62(12):1565-1568. doi: 10.1373/clinchem.2016.259473. [PMID: 27899453]
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  • Sam D Cook, John J Ross. The auxins, IAA and PAA, are synthesized by similar steps catalyzed by different enzymes. Plant signaling & behavior. 2016 11; 11(11):e1250993. doi: 10.1080/15592324.2016.1250993. [PMID: 27808586]
  • Juliana F Saldanha, Dan Yi, Milena B Stockler-Pinto, Hédi A Soula, Stéphane Chambert, Denis Fouque, Denise Mafra, Christophe O Soulage. Determination of the binding properties of the uremic toxin phenylacetic acid to human serum albumin. Biochimie. 2016 Jun; 125(?):53-8. doi: 10.1016/j.biochi.2016.03.002. [PMID: 26945842]
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