Rotenone (BioDeep_00000000136)

 

Secondary id: BioDeep_00000270590

human metabolite PANOMIX_OTCML-2023 Toxin


代谢物信息卡片


[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, [2R-(2alpha,6aalpha,12aalpha)]-

化学式: C23H22O6 (394.1416312)
中文名称: 鱼藤酮
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.22%

分子结构信息

SMILES: C12O[C@@]([H])(C(=C)C)CC1=C1O[C@]3([H])COC4C=C(OC)C(OC)=CC=4[C@]3([H])C(=O)C1=CC=2
InChI: InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1

描述信息

Rotenone appears as colorless to brownish crystals or a white to brownish-white crystalline powder. Has neither odor nor taste. (NTP, 1992)
Rotenone is a member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica). It has a role as a phytogenic insecticide, a mitochondrial NADH:ubiquinone reductase inhibitor, a metabolite, an antineoplastic agent, a toxin and a piscicide. It is an organic heteropentacyclic compound and a member of rotenones.
Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also toxic to fish.
Rotenone is a natural product found in Pachyrhizus erosus, Millettia ferruginea, and other organisms with data available.
Rotenone is a naturally occurring organic heteropentacyclic compound and member of rotenones that is found in the roots of several plant species. It is a mitochondrial NADH:ubiquinone reductase inhibitor, toxin, and metabolite, and is used as an antineoplastic agent and insecticide. It is characterized as a colorless to brownish or a white to brownish-white crystalline solid that is odorless. Exposure occurs by inhalation, ingestion, or contact.
Rotenone is found in jicama. Rotenone is widely distributed in the Leguminosae (Papilionoideae) e.g. Pachyrrhizus erosus (yam bean).Rotenone is an odorless chemical that is used as a broad-spectrum insecticide, piscicide, and pesticide. It occurs naturally in the roots and stems of several plants such as the jicama vine plant. In mammals, including humans, it is linked to the development of Parkinsons disease. (Wikipedia) Rotenone has been shown to exhibit apoptotic, neuroprotectant and neuroprotective functions (A7776, A7777, A7777).Rotenone belongs to the family of Rotenoids. These are phenolic compounds containing aA cis-fused tetrahydrochromeno[3,4-b]chromenenucleus. Many rotenoids contain an additional ring, e.g rotenone[1]. (Reference: [1] IUPAC. Compendium of Chemical Terminology, 2nd ed. (the Gold Book). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. doi:10.1351/goldbook. (PAC, 1995, 67, 1307 (Glossary of class names of organic compounds and reactivity intermediates based on structure (IUPAC Recommendations 1995)) on page 1364)).
A botanical insecticide that is an inhibitor of mitochondrial electron transport.
Rotenone is found in jicama. Rotenone is widely distributed in the Leguminosae (Papilionoideae) e.g. Pachyrrhizus erosus (yam bean).Rotenone is an odorless chemical that is used as a broad-spectrum insecticide, piscicide, and pesticide. It occurs naturally in the roots and stems of several plants such as the jicama vine plant. In mammals, including humans, it is linked to the development of Parkinsons disease.
A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Widely distrib. in the Leguminosae (Papilionoideae) e.g. Pachyrrhizus erosus (yam bean)
D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

同义名列表

130 个代谢物同义名

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, [2R-(2alpha,6aalpha,12aalpha)]-; (1S,6R,13S)-16,17-dimethoxy-6-(prop-1-en-2-yl)-2,7,20-trioxapentacyclo[11.8.0.0^{3,11}.0^{4,8}.0^{14,19}]henicosa-3,8,10,14(19),15,17-hexaen-12-one; (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R-(2alpha,6aalpha,12aalpha))-; [2R-(2alpha,6aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-H][1]benzopyran-6(6aH)-one; [1]Benzopyrano[3,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, [2R-(2.alpha.,6a.alpha.,12a.alpha.)]-; (2R-(2alpha,6aalpha,12aalpha))-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)(1)benzopyrano(3,4-b)furo(2,3-h)benzopyran-6(6aH)-one; [2R-(2a,6Aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-H][1]benzopyran-6(6ah)-one; (1S,6R,13S)-16,17-dimethoxy-6-prop-1-en-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one; [2R-(2Α,6aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-H][1]benzopyran-6(6ah)-one; [1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)- (9CI); [1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)-; (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)-; [1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aalphaH)-one, 1,2,12,12aalpha-tetrahydro-2alpha-isopropenyl-8,9-dimethoxy- (8CI); (2R,6aS,12aS)-8,9-Dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrofuro[2,3:7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6aH)-one; (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one; (2R,6AS,12AS)-1,2,12,12A-TETRAHYDRO-8,9-DIMETHOXY-2-(1-METHYLETHENYL)(1)BENZOPYRANO(3,4-B)FURO(2,3-H)(1)BENZOPYRAN-6(6AH)-ONE; Tubatoxin 1,2,12,12a,-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]-benzopyran-6(6aH)-one; [1]Benzopyrano[3,3-h][1]benzopyran-6(6a.alpha.H)-one, 1,2,12,12a.alpha.-tetrahydro-2.alpha.-isopropenyl-8,9-dimethoxy-; 1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 9CI; (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-alpha-isopropenyl-8,9-dimethoxy-; 1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-(1)benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one; (2R,6aS,12aS)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one; 1,2,12,12aalpha-Tetrahydro-2a-isopropenyl-8,9-dimethoxy(1)benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one; (2R,6aS,12aS)-1,2,6,6a,12,12a- hexahydro-2-isopropenyl-8,9- dimethoxychromeno[3,4-b] furo(2,3-h)chromen-6-one; (2R,6aS,12aS)-2-isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one; (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one; (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno(3,4-b)furo(2,3-h)chromen-6-one; (1)Benzopyrano[3,3-h](1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-.alpha.-iospropenyl-8,9-dimethoxy-; [1]Benzopyrano[3,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-.alpha.-isopropenyl-8,9-dimethoxy-; (2R-(6aalpha,12aalpha)-1,2-Dihydro-2-isopropenyl-8,9-dimethoxychromano(3,4-b)furo(2,3-h)chroman-6-one; (2R-(6aalpha,12aalpha)-1,2-Dihydro-2-isopropenyl-8,9-dimethoxychromano(3,4-b)furo(2,3-h)chroman-6-on; (12aS,6aS,2R)-8,9-dimethoxy-2-(1-methylvinyl)-1,2-dihydrochromano[3,4-b]furano [2,3-h]chroman-6-one; [1]Benzopyrano[3,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-isopropenyl-8,9-dimethoxy-; WLN: T G5 D6 B666 CV HO MO POT&TT&J IY1&U1 SO1 TO1; Rotenone, PESTANAL(R), analytical standard; inhibits NADH2 oxidation to NAD; isopropenyl(dimethoxy)[?]one; JUVIOZPCNVVQFO-HBGVWJBISA-N; Green Cross Warble Powder; ROTENONE [GREEN BOOK]; Derris (insecticide); Rotenone, commercial; Rotenona [Spanish]; Rotenone [BSI:ISO]; Curex flea duster; Cenol garden dust; Rotenone, dehydro; (-)-cis-Rotenone; Spectrum4_001638; Spectrum2_000457; ROTENONE [MART.]; Spectrum5_000455; Rotenone, >=95\\%; 5.beta.-Rotenone; Spectrum3_000158; ROTENONE [HSDB]; 5-beta-Rotenone; UNII-03L9OT429T; ROTENONE [ISO]; Foliafume E.C.; Tox21_110819_1; Rotenone (7CI); 5beta-rotenone; 5beta-Rotenone; Rotocide E.C.; Derris resins; DivK1c_000947; ROTENONE [MI]; Lopac0_001112; Liquid Derris; Rotacide E.C.; Tox21_110819; (-)-Rotenone; KBio2_003033; KBio2_000465; KBio3_001116; KBio2_005601; KBio1_000947; NCI60_002093; Derris, JMAF; Tox21_300695; Tox21_201904; Tox21_501112; 5Β-rotenone; CAS-83-79-4; Rotenox 5EC; IDI1_000947; 5b-Rotenone; Cube-Pulver; Rotessenol; 03L9OT429T; Nicouline; Tubotoxin; Paraderil; AI3-00133; Roteonone; Chem-Mite; Tubatoxin; Rotefour; C23H22O6; Rotocide; Rotefive; Dactinol; Rotenona; Rotenone; Barbasco; Rotenoid; Synpren; Dri-Kil; Noxfire; Rotenox; Prentox; Rotenon; Noxfish; Derrin; Ronone; Gerane; Haiari; Protax; Pb-nox; Mexide; Extrax; Derris; Nekoe; Canex; Ro-Ko; Deril; Cubor; CUBE; (2R,6aS,12aS)-1,2,6,6a,12,12a- hexahydro-2-isopropenyl-8,9- dimethoxychromeno[3,4-b] furo(2,3-h)chromen-6-one



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

57 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Aruna Chanu Hijam, Yaiphabi Chanu Tongbram, Pooja Devi Nongthombam, Heikrujam Nilkanta Meitei, Arunkumar Singh Koijam, Yallapa Rajashekar, Reena Haobam. Neuroprotective potential of traditionally used medicinal plants of Manipur against rotenone-induced neurotoxicity in SH-SY5Y neuroblastoma cells. Journal of ethnopharmacology. 2024 Aug; 330(?):118197. doi: 10.1016/j.jep.2024.118197. [PMID: 38636579]
  • Lu Tian, Peiyan Tang, Jianing Liu, Yiyang Liu, Liyan Hou, Jie Zhao, Qingshan Wang. Microglial gp91phox-mediated neuroinflammation and ferroptosis contributes to learning and memory deficits in rotenone-treated mice. Free radical biology & medicine. 2024 Aug; 220(?):56-66. doi: 10.1016/j.freeradbiomed.2024.04.240. [PMID: 38697489]
  • Ricardo Gomes Dos Santos Nunes, Luciclaudio Cassimiro de Amorim, Iverson Conrado Bezerra, Artur José da Silva, Carlos Alonso Leite Dos Santos, Priscila Gubert, Irwin Rose Alencar de Menezesa, Antonia Eliene Duarte, Luiz Marivando Barros, Belmira Lara da Silveira Andrade-da-Costa, Márcia Vanusa Dos Santos, Maria Tereza Dos Santos Correia, Michelle Melgarejo da Rosa. Syagrus coronata fixed oil prevents rotenone-induced movement disorders and oxidative stress in Drosophila melanogaster. Journal of toxicology and environmental health. Part A. 2024 Jun; 87(12):497-515. doi: 10.1080/15287394.2024.2338431. [PMID: 38619158]
  • Min Hong, Juan Wang, Haobin Chen, Jiayu Qi, Qinghong Ji, Xiaoyan Liu, Qiaoli Yue, Lei Li, Shuang Cheng. Synthesis and biological evaluation of folic acid-rotenol conjugate as a potent targeted anticancer prodrug. European journal of pharmacology. 2024 May; 970(?):176482. doi: 10.1016/j.ejphar.2024.176482. [PMID: 38452835]
  • Ivan Kiganda, Jonathan Bogaerts, Lianne H E Wieske, Tsegaye Deyou, Yoseph Atilaw, Colores Uwamariya, Masum Miah, Joanna Said, Albert Ndakala, Hoseah M Akala, Wouter Herrebout, Edward Trybala, Tomas Bergström, Abiy Yenesew, Mate Erdelyi. Antiviral Rotenoids and Isoflavones Isolated from Millettia oblata ssp. teitensis. Journal of natural products. 2024 Apr; 87(4):1003-1012. doi: 10.1021/acs.jnatprod.3c01288. [PMID: 38579352]
  • Rosanna Mallamaci, Debora Musarò, Marco Greco, Antonello Caponio, Stefano Castellani, Anas Munir, Lorenzo Guerra, Marina Damato, Giuseppe Fracchiolla, Chiara Coppola, Rosa Angela Cardone, Mehdi Rashidi, Roberta Tardugno, Sara Sergio, Adriana Trapani, Michele Maffia. Dopamine- and Grape-Seed-Extract-Loaded Solid Lipid Nanoparticles: Interaction Studies between Particles and Differentiated SH-SY5Y Neuronal Cell Model of Parkinson's Disease. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081774. [PMID: 38675592]
  • Emmanuel Makinde, Linlin Ma, George D Mellick, Yunjiang Feng. A High-Throughput Screening of a Natural Products Library for Mitochondria Modulators. Biomolecules. 2024 Apr; 14(4):. doi: 10.3390/biom14040440. [PMID: 38672457]
  • Emad Albadawi, Ahmed El-Tokhy, Muayad Albadrani, Mohammed Adel, Randa El-Gamal, Wael Zaarina, Mosaab Salah El-Din El-Agawy, Hassan Reda Hassan Elsayed. The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats. Tissue & cell. 2024 Apr; 87(?):102328. doi: 10.1016/j.tice.2024.102328. [PMID: 38387425]
  • Taiwo G Olubodun-Obadun, Ismail O Ishola, Oluwabusayo R Folarin, Farouk A Oladoja, Taidinda T Gilbert, Ifunanya M Aniekwensi, Afolabi Bisiriyu, Nkem A Joseph-Iwebi, Foluke O Adebanjo, James O Olopade, Olufunmilayo O Adeyemi. Cajanus cajan (L) Millsp seeds extract prevents rotenone-induced motor- and non-motor features of Parkinson disease in mice: Insight into mechanisms of neuroprotection. Journal of ethnopharmacology. 2024 Mar; 322(?):117623. doi: 10.1016/j.jep.2023.117623. [PMID: 38128890]
  • Chun Dai, Wei Ge, Tianyu Li, Xiuqi Kong, Minggang Tian, Jie Niu. Single Fluorescent Probe for Multiple Tasks: Illuminating Lipid Droplets and Lysosomes in Dual Channels and Distinguishing Autophagy and Apoptosis. Analytical chemistry. 2024 Mar; 96(10):4013-4022. doi: 10.1021/acs.analchem.3c03653. [PMID: 38426215]
  • Sara Linjacki, Yuehong Wang, Navjeet Baath, Devin Mantle, Guangdong Yang. H2S Protects from Rotenone-Induced Ferroptosis by Stabilizing Fe-S Clusters in Rat Cardiac Cells. Cells. 2024 Feb; 13(5):. doi: 10.3390/cells13050371. [PMID: 38474335]
  • Qingquan Sun, Yan Wang, Liyan Hou, Sheng Li, Jau-Shyong Hong, Qingshan Wang, Jie Zhao. Clozapine-N-oxide protects dopaminergic neurons against rotenone-induced neurotoxicity by preventing ferritinophagy-mediated ferroptosis. Free radical biology & medicine. 2024 02; 212(?):384-402. doi: 10.1016/j.freeradbiomed.2023.12.045. [PMID: 38182072]
  • Yu-Juan Yao, Ning-Na Yin, Lin-Mei Pu, An-Jing Yang, Nai-Yong Liu. Three chemosensory proteins enriched in antennae and tarsi of Rhaphuma horsfieldi differentially contribute to the binding of insecticides. Pesticide biochemistry and physiology. 2024 Feb; 199(?):105797. doi: 10.1016/j.pestbp.2024.105797. [PMID: 38458690]
  • Rosanne Wouters, Igor Beletchi, Chris Van den Haute, Veerle Baekelandt, Shaun Martin, Jan Eggermont, Peter Vangheluwe. The lipid flippase ATP10B enables cellular lipid uptake under stress conditions. Biochimica et biophysica acta. Molecular cell research. 2024 02; 1871(2):119652. doi: 10.1016/j.bbamcr.2023.119652. [PMID: 38086447]
  • Jingbo Liu, Bingyan Guo, Siying Zhong, Yabing Shi, Zhengping Li, Zhenwu Yu, Zesheng Hao, Li Zhang, Fengyun Li, Yuanhong Wang, Yuxin Li. Novel Evodiamine-Based Sulfonamide Derivatives as Potent Insecticide Candidates Targeting Insect Ryanodine Receptors. Journal of agricultural and food chemistry. 2024 Jan; 72(2):1292-1301. doi: 10.1021/acs.jafc.3c05680. [PMID: 38178001]
  • Jieteng Chen, Xiaohuan Mu, Huiling Liu, Qiyao Yong, Xiaoman Ouyang, Yan Liu, Li Zheng, Hao Chen, Yifan Zhai, Jie Ma, Liang Meng, Shanshan Liu, Hao Zheng. Rotenone impairs brain glial energetics and locomotor behavior in bumblebees. The Science of the total environment. 2024 Jan; 907(?):167870. doi: 10.1016/j.scitotenv.2023.167870. [PMID: 37865240]
  • Wenyuan Xu, You Dai. Lipid Carrier Nanostructured Astilbin Ameliorates Rotenone-Induced Neurodegeneration in Mice Brain via Modulation of GSK3β-Nrf2 Signaling Pathways. Journal of oleo science. 2024; 73(3):371-387. doi: 10.5650/jos.ess23173. [PMID: 38433001]
  • Rabia Anjum, Chand Raza, Mehwish Faheem, Arif Ullah, Maham Chaudhry. Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities. PloS one. 2024; 19(4):e0302102. doi: 10.1371/journal.pone.0302102. [PMID: 38625964]
  • Si Ling Yeoh, Pheik Sian Choong, Rahmad Zakaria, Nur Azzalia Kamaruzaman, Sazaroni Md Rashid, Mohd Fadhli Razali, Ahmad Khaldun Ismail. A case of rotenone poisoning from ingesting Derris trifoliata Lour. (Tuba fruit/pod) in Malaysia. Toxicon : official journal of the International Society on Toxinology. 2024 Jan; 237(?):107557. doi: 10.1016/j.toxicon.2023.107557. [PMID: 38072318]
  • Noha Nabil Mohammed, Mariane G Tadros, Mina Y George. Empagliflozin repurposing in Parkinson's disease; modulation of oxidative stress, neuroinflammation, AMPK/SIRT-1/PGC-1α, and wnt/β-catenin pathways. Inflammopharmacology. 2023 Dec; ?(?):. doi: 10.1007/s10787-023-01384-w. [PMID: 38038781]
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