Rotenone (BioDeep_00000270590)

Main id: BioDeep_00000000136

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Pesticide4_Rotenone_C23H22O6_Furo[2,3:7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)-

化学式: C23H22O6 (394.1416)
中文名称: 鱼藤酮, 鱼滕酮
谱图信息: 最多检出来源 Ferula hexiensis(otcml) 12.89%

分子结构信息

SMILES: C=C(C)C1Cc2c(ccc3c2OC2COc4cc(OC)c(OC)cc4C2C3=O)O1
InChI: InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3

描述信息

Origin: Plant, Pyrans
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.283
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.281
Acquisition and generation of the data is financially supported by the Max-Planck-Society
D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
IPB_RECORD: 2241; CONFIDENCE confident structure
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

同义名列表

7 个代谢物同义名

Rotenone; Pesticide4_Rotenone_C23H22O6_Furo[2,3:7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)-; (2R,6aS,12aS) -8,9-Dimethoxy-2- (prop-1-en-2-yl) -1,2,12,12a-tetrahydrochromeno [3,4-b] furo [2,3-h] chromen-6 (6aH) -one; Nicouline; Tubotoxin; Rotenone; Rotenone



数据库引用编号

77 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

29 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ANXA5, ATF4, ATG5, CASP1, CRYZ, DDIT3, HTT, MAPK14, MAPK8, NOS2, PIK3C3, TP53
Peripheral membrane protein 3 ANXA5, ATG5, HSD17B6
Endosome membrane 1 HTT
Endoplasmic reticulum membrane 1 CYBB
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 8 ATF4, DDIT3, HTT, JUN, MAPK14, MAPK8, NOS2, TP53
autophagosome 3 ATG5, HTT, PIK3C3
cytosol 13 ANXA5, ATF4, ATG5, CASP1, CRYZ, DDIT3, GSR, HTT, MAPK14, MAPK8, NOS2, PIK3C3, TP53
dendrite 2 CYBB, HTT
phagocytic vesicle 1 CYBB
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 2 ATF4, TP53
nucleoplasm 8 ATF4, ATP2B1, HTT, JUN, MAPK14, MAPK8, NOS2, TP53
RNA polymerase II transcription regulator complex 3 ATF4, DDIT3, JUN
Cell membrane 5 ATF4, ATP2B1, CASP1, CYBB, HTT
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 4 ATP2B1, CYBB, HTT, KCNA3
Synapse 3 ATP2B1, HTT, MAPK8
glutamatergic synapse 5 ATG5, ATP2B1, KCNA3, MAPK14, PIK3C3
Golgi apparatus 2 GDNF, HTT
neuronal cell body 1 CYBB
postsynapse 1 ATG5
presynaptic membrane 3 ATP2B1, HTT, KCNA3
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 NOS2
endosome 1 PIK3C3
plasma membrane 6 ATP2B1, CASP1, CYBB, HTT, KCNA3, NOS2
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ANXA5, ATG5, ATP2B1, CYBB, KCNA3, PIK3C3, TP53
axon 4 ATG5, HTT, KCNA3, MAPK8
basolateral plasma membrane 1 ATP2B1
extracellular exosome 5 ANXA5, ATP2B1, CRYZ, GSR, SOD2
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 HSD17B6, HTT, TP53
extracellular space 1 GDNF
perinuclear region of cytoplasm 3 HTT, KCNA3, NOS2
Schaffer collateral - CA1 synapse 1 ATG5
mitochondrion 5 CRYZ, GSR, MAPK14, SOD2, TP53
protein-containing complex 5 ATF4, ATG5, CASP1, HTT, TP53
intracellular membrane-bounded organelle 2 ATP2B1, HSD17B6
Microsome membrane 1 HSD17B6
Secreted 1 GDNF
extracellular region 3 ANXA5, GDNF, MAPK14
Mitochondrion matrix 2 SOD2, TP53
mitochondrial matrix 3 GSR, SOD2, TP53
transcription regulator complex 3 DDIT3, JUN, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 ATF4, TP53
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 ANXA5, GSR
nucleolus 2 CASP1, TP53
midbody 1 PIK3C3
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 HTT
postsynaptic membrane 2 HTT, KCNA3
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 2 HTT, KCNA3
Cell junction, focal adhesion 1 HTT
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 ANXA5, HTT
microtubule 1 CASP1
GABA-ergic synapse 1 PIK3C3
mitochondrial nucleoid 1 SOD2
Peroxisome 2 NOS2, PIK3C3
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 ANXA5
lateral plasma membrane 1 ATP2B1
axoneme 2 ATG5, PIK3C3
nuclear speck 2 ATF4, MAPK14
NLRP3 inflammasome complex 1 CASP1
Late endosome 3 DDIT3, HTT, PIK3C3
Cell projection, neuron projection 1 HTT
Zymogen granule membrane 1 ANXA5
neuron projection 2 ATF4, HTT
chromatin 4 ATF4, DDIT3, JUN, TP53
cell projection 1 ATP2B1
phagocytic vesicle membrane 3 ATG5, CYBB, PIK3C3
centriole 1 HTT
spindle pole 1 MAPK14
nuclear chromosome 1 JUN
Basolateral cell membrane 1 ATP2B1
[Isoform 2]: Cell membrane 1 KCNA3
site of double-strand break 1 TP53
nuclear envelope 1 CYBB
Endomembrane system 1 HTT
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
monoatomic ion channel complex 1 CYBB
Preautophagosomal structure membrane 1 ATG5
Atg12-Atg5-Atg16 complex 1 ATG5
mitochondria-associated endoplasmic reticulum membrane contact site 1 ATG5
phagophore assembly site membrane 1 ATG5
Cytoplasmic vesicle membrane 1 HTT
specific granule membrane 1 CYBB
tertiary granule membrane 1 CYBB
Nucleus speckle 1 ATF4
euchromatin 1 JUN
Presynaptic cell membrane 1 ATP2B1
germ cell nucleus 1 TP53
replication fork 1 TP53
voltage-gated potassium channel complex 1 KCNA3
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
immunological synapse 1 ATP2B1
presynaptic endosome 1 PIK3C3
perinuclear endoplasmic reticulum 1 CYBB
calyx of Held 1 KCNA3
AIM2 inflammasome complex 1 CASP1
vesicle membrane 1 ANXA5
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 DDIT3
basal dendrite 1 MAPK8
canonical inflammasome complex 1 CASP1
[Isoform 1]: Cell membrane 1 KCNA3
dendrite membrane 1 ATF4
postsynaptic cytosol 1 HTT
nuclear periphery 1 ATF4
presynaptic cytosol 1 HTT
transferase complex 1 ATG5
postsynaptic endosome 1 PIK3C3
transcription factor AP-1 complex 1 JUN
cortical cytoskeleton 1 NOS2
Autolysosome 1 PIK3C3
inclusion body 1 HTT
NADPH oxidase complex 1 CYBB
endothelial microparticle 1 ANXA5
photoreceptor ribbon synapse 1 ATP2B1
ATF4-CREB1 transcription factor complex 1 ATF4
CHOP-C/EBP complex 1 DDIT3
ATF1-ATF4 transcription factor complex 1 ATF4
CHOP-ATF3 complex 1 DDIT3
CHOP-ATF4 complex 2 ATF4, DDIT3
Lewy body core 1 ATF4
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
serotonergic synapse 1 HTT
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
phagophore 1 ATG5


文献列表

  • Aruna Chanu Hijam, Yaiphabi Chanu Tongbram, Pooja Devi Nongthombam, Heikrujam Nilkanta Meitei, Arunkumar Singh Koijam, Yallapa Rajashekar, Reena Haobam. Neuroprotective potential of traditionally used medicinal plants of Manipur against rotenone-induced neurotoxicity in SH-SY5Y neuroblastoma cells. Journal of ethnopharmacology. 2024 Aug; 330(?):118197. doi: 10.1016/j.jep.2024.118197. [PMID: 38636579]
  • Lu Tian, Peiyan Tang, Jianing Liu, Yiyang Liu, Liyan Hou, Jie Zhao, Qingshan Wang. Microglial gp91phox-mediated neuroinflammation and ferroptosis contributes to learning and memory deficits in rotenone-treated mice. Free radical biology & medicine. 2024 Aug; 220(?):56-66. doi: 10.1016/j.freeradbiomed.2024.04.240. [PMID: 38697489]
  • Ricardo Gomes Dos Santos Nunes, Luciclaudio Cassimiro de Amorim, Iverson Conrado Bezerra, Artur José da Silva, Carlos Alonso Leite Dos Santos, Priscila Gubert, Irwin Rose Alencar de Menezesa, Antonia Eliene Duarte, Luiz Marivando Barros, Belmira Lara da Silveira Andrade-da-Costa, Márcia Vanusa Dos Santos, Maria Tereza Dos Santos Correia, Michelle Melgarejo da Rosa. Syagrus coronata fixed oil prevents rotenone-induced movement disorders and oxidative stress in Drosophila melanogaster. Journal of toxicology and environmental health. Part A. 2024 Jun; 87(12):497-515. doi: 10.1080/15287394.2024.2338431. [PMID: 38619158]
  • Min Hong, Juan Wang, Haobin Chen, Jiayu Qi, Qinghong Ji, Xiaoyan Liu, Qiaoli Yue, Lei Li, Shuang Cheng. Synthesis and biological evaluation of folic acid-rotenol conjugate as a potent targeted anticancer prodrug. European journal of pharmacology. 2024 May; 970(?):176482. doi: 10.1016/j.ejphar.2024.176482. [PMID: 38452835]
  • Ivan Kiganda, Jonathan Bogaerts, Lianne H E Wieske, Tsegaye Deyou, Yoseph Atilaw, Colores Uwamariya, Masum Miah, Joanna Said, Albert Ndakala, Hoseah M Akala, Wouter Herrebout, Edward Trybala, Tomas Bergström, Abiy Yenesew, Mate Erdelyi. Antiviral Rotenoids and Isoflavones Isolated from Millettia oblata ssp. teitensis. Journal of natural products. 2024 Apr; 87(4):1003-1012. doi: 10.1021/acs.jnatprod.3c01288. [PMID: 38579352]
  • Rosanna Mallamaci, Debora Musarò, Marco Greco, Antonello Caponio, Stefano Castellani, Anas Munir, Lorenzo Guerra, Marina Damato, Giuseppe Fracchiolla, Chiara Coppola, Rosa Angela Cardone, Mehdi Rashidi, Roberta Tardugno, Sara Sergio, Adriana Trapani, Michele Maffia. Dopamine- and Grape-Seed-Extract-Loaded Solid Lipid Nanoparticles: Interaction Studies between Particles and Differentiated SH-SY5Y Neuronal Cell Model of Parkinson's Disease. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081774. [PMID: 38675592]
  • Emmanuel Makinde, Linlin Ma, George D Mellick, Yunjiang Feng. A High-Throughput Screening of a Natural Products Library for Mitochondria Modulators. Biomolecules. 2024 Apr; 14(4):. doi: 10.3390/biom14040440. [PMID: 38672457]
  • Emad Albadawi, Ahmed El-Tokhy, Muayad Albadrani, Mohammed Adel, Randa El-Gamal, Wael Zaarina, Mosaab Salah El-Din El-Agawy, Hassan Reda Hassan Elsayed. The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats. Tissue & cell. 2024 Apr; 87(?):102328. doi: 10.1016/j.tice.2024.102328. [PMID: 38387425]
  • Taiwo G Olubodun-Obadun, Ismail O Ishola, Oluwabusayo R Folarin, Farouk A Oladoja, Taidinda T Gilbert, Ifunanya M Aniekwensi, Afolabi Bisiriyu, Nkem A Joseph-Iwebi, Foluke O Adebanjo, James O Olopade, Olufunmilayo O Adeyemi. Cajanus cajan (L) Millsp seeds extract prevents rotenone-induced motor- and non-motor features of Parkinson disease in mice: Insight into mechanisms of neuroprotection. Journal of ethnopharmacology. 2024 Mar; 322(?):117623. doi: 10.1016/j.jep.2023.117623. [PMID: 38128890]
  • Chun Dai, Wei Ge, Tianyu Li, Xiuqi Kong, Minggang Tian, Jie Niu. Single Fluorescent Probe for Multiple Tasks: Illuminating Lipid Droplets and Lysosomes in Dual Channels and Distinguishing Autophagy and Apoptosis. Analytical chemistry. 2024 Mar; 96(10):4013-4022. doi: 10.1021/acs.analchem.3c03653. [PMID: 38426215]
  • Sara Linjacki, Yuehong Wang, Navjeet Baath, Devin Mantle, Guangdong Yang. H2S Protects from Rotenone-Induced Ferroptosis by Stabilizing Fe-S Clusters in Rat Cardiac Cells. Cells. 2024 Feb; 13(5):. doi: 10.3390/cells13050371. [PMID: 38474335]
  • Qingquan Sun, Yan Wang, Liyan Hou, Sheng Li, Jau-Shyong Hong, Qingshan Wang, Jie Zhao. Clozapine-N-oxide protects dopaminergic neurons against rotenone-induced neurotoxicity by preventing ferritinophagy-mediated ferroptosis. Free radical biology & medicine. 2024 02; 212(?):384-402. doi: 10.1016/j.freeradbiomed.2023.12.045. [PMID: 38182072]
  • Yu-Juan Yao, Ning-Na Yin, Lin-Mei Pu, An-Jing Yang, Nai-Yong Liu. Three chemosensory proteins enriched in antennae and tarsi of Rhaphuma horsfieldi differentially contribute to the binding of insecticides. Pesticide biochemistry and physiology. 2024 Feb; 199(?):105797. doi: 10.1016/j.pestbp.2024.105797. [PMID: 38458690]
  • Rosanne Wouters, Igor Beletchi, Chris Van den Haute, Veerle Baekelandt, Shaun Martin, Jan Eggermont, Peter Vangheluwe. The lipid flippase ATP10B enables cellular lipid uptake under stress conditions. Biochimica et biophysica acta. Molecular cell research. 2024 02; 1871(2):119652. doi: 10.1016/j.bbamcr.2023.119652. [PMID: 38086447]
  • Jingbo Liu, Bingyan Guo, Siying Zhong, Yabing Shi, Zhengping Li, Zhenwu Yu, Zesheng Hao, Li Zhang, Fengyun Li, Yuanhong Wang, Yuxin Li. Novel Evodiamine-Based Sulfonamide Derivatives as Potent Insecticide Candidates Targeting Insect Ryanodine Receptors. Journal of agricultural and food chemistry. 2024 Jan; 72(2):1292-1301. doi: 10.1021/acs.jafc.3c05680. [PMID: 38178001]
  • Jieteng Chen, Xiaohuan Mu, Huiling Liu, Qiyao Yong, Xiaoman Ouyang, Yan Liu, Li Zheng, Hao Chen, Yifan Zhai, Jie Ma, Liang Meng, Shanshan Liu, Hao Zheng. Rotenone impairs brain glial energetics and locomotor behavior in bumblebees. The Science of the total environment. 2024 Jan; 907(?):167870. doi: 10.1016/j.scitotenv.2023.167870. [PMID: 37865240]
  • Wenyuan Xu, You Dai. Lipid Carrier Nanostructured Astilbin Ameliorates Rotenone-Induced Neurodegeneration in Mice Brain via Modulation of GSK3β-Nrf2 Signaling Pathways. Journal of oleo science. 2024; 73(3):371-387. doi: 10.5650/jos.ess23173. [PMID: 38433001]
  • Rabia Anjum, Chand Raza, Mehwish Faheem, Arif Ullah, Maham Chaudhry. Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities. PloS one. 2024; 19(4):e0302102. doi: 10.1371/journal.pone.0302102. [PMID: 38625964]
  • Si Ling Yeoh, Pheik Sian Choong, Rahmad Zakaria, Nur Azzalia Kamaruzaman, Sazaroni Md Rashid, Mohd Fadhli Razali, Ahmad Khaldun Ismail. A case of rotenone poisoning from ingesting Derris trifoliata Lour. (Tuba fruit/pod) in Malaysia. Toxicon : official journal of the International Society on Toxinology. 2024 Jan; 237(?):107557. doi: 10.1016/j.toxicon.2023.107557. [PMID: 38072318]
  • Noha Nabil Mohammed, Mariane G Tadros, Mina Y George. Empagliflozin repurposing in Parkinson's disease; modulation of oxidative stress, neuroinflammation, AMPK/SIRT-1/PGC-1α, and wnt/β-catenin pathways. Inflammopharmacology. 2023 Dec; ?(?):. doi: 10.1007/s10787-023-01384-w. [PMID: 38038781]
  • Piyong Sola, Kusuma Kumari Garikapati, Praveen Thaggikuppe Krishnamurthy, Mamta Kumari. Polysorbate 80 surface modified SLNs of formoterol suppress SNCA gene and mitochondrial oxidative stress in mice model of Parkinson's disease. Scientific reports. 2023 11; 13(1):19942. doi: 10.1038/s41598-023-46511-3. [PMID: 37968340]
  • Yujing Zhao, Jingjie An, Zhihong Dang, Jianglong Guo, Zhanlin Gao, Shujie Ma, Yaofa Li. Identification of highly active compounds from insecticidal plant Oroxylum indicum L. (Vent.) and the induction of apoptosis by lapachol on Sf9 cells. In vitro cellular & developmental biology. Animal. 2023 Nov; ?(?):. doi: 10.1007/s11626-023-00821-y. [PMID: 37966689]
  • Leysan Vasileva, Gulnara Gaynanova, Darya Kuznetsova, Farida Valeeva, Anna Lyubina, Syumbelya Amerhanova, Alexandra Voloshina, Guzel Sibgatullina, Dmitry Samigullin, Konstantin Petrov, Lucia Zakharova. Mitochondria-Targeted Lipid Nanoparticles Loaded with Rotenone as a New Approach for the Treatment of Oncological Diseases. Molecules (Basel, Switzerland). 2023 Oct; 28(20):. doi: 10.3390/molecules28207229. [PMID: 37894708]
  • Syeda Madiha, Zehra Batool, Sidrah Shahzad, Saiqa Tabassum, Laraib Liaquat, Asia Afzal, Sadia Sadir, Irfan Sajid, Bushra Jabeen Mehdi, Saara Ahmad, Saida Haider. Naringenin, a Functional Food Component, Improves Motor and Non-Motor Symptoms in Animal Model of Parkinsonism Induced by Rotenone. Plant foods for human nutrition (Dordrecht, Netherlands). 2023 Oct; ?(?):. doi: 10.1007/s11130-023-01103-4. [PMID: 37796415]
  • Wangjin Xu, Dianjing Shen, Xiaojun Chen, Ming Zhao, Tianle Fan, Qinchao Wu, Zhiyuan Meng, Jiajia Cui. Rotenone nanoparticles based on mesoporous silica to improve the stability, translocation and insecticidal activity of rotenone. Environmental science and pollution research international. 2023 Sep; ?(?):. doi: 10.1007/s11356-023-29842-6. [PMID: 37723398]
  • Yilmaz Kocak, Gokhan Oto, Zubeyir Huyut, Hamit Hakan Alp, Fikret Turkan, Ezgi Onay. Effects of fluoride on oxidative DNA damage, nitric oxide level, lipid peroxidation and cholinesterase enzyme activity in a rotenone-induced experimental Parkinson's model. Neurological research. 2023 Sep; ?(?):1-9. doi: 10.1080/01616412.2023.2257452. [PMID: 37699078]
  • Derya Cansiz, Ismail Unal, Merih Beler, Unsal Veli Ustundag, Esin Ak, Ebru Emekli-Alturfan, Ahmet Ata Alturfan. The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish. Neurotoxicology. 2023 Sep; ?(?):. doi: 10.1016/j.neuro.2023.09.004. [PMID: 37683694]
  • Yu Zhang, Sheng Li, Liyan Hou, Mingyang Wu, Jianing Liu, Ruonan Wang, Qingshan Wang, Jie Zhao. NLRP3 mediates the neuroprotective effects of SVHRSP derived from scorpion venom in rotenone-induced experimental Parkinson's disease model. Journal of ethnopharmacology. 2023 Aug; 312(?):116497. doi: 10.1016/j.jep.2023.116497. [PMID: 37072089]
  • Qian Zhou, Bin Chen, Yijiao Xu, Yue Wang, Ziheng He, Xueting Cai, Yu Qin, Juan Ye, Yang Yang, Jianping Shen, Peng Cao. Geniposide protects against neurotoxicity in mouse models of rotenone-induced Parkinson's disease involving the mTOR and Nrf2 pathways. Journal of ethnopharmacology. 2023 Jul; ?(?):116914. doi: 10.1016/j.jep.2023.116914. [PMID: 37451492]
  • Eman Abdelrazik, Hend M Hassan, Eman Hamza, Farah M Ezz Elregal, Marwa H Elnagdy, Eman A Abdulhai. Beneficial role of rosemary extract on oxidative stress-mediated neuronal apoptosis in rotenone-induced attention deficit hyperactivity disease in juvenile rat model. Acta bio-medica : Atenei Parmensis. 2023 Jun; 94(3):e2023104. doi: 10.23750/abm.v94i3.14260. [PMID: 37326266]
  • Sheikh Azimullah, Mohamed Fizur Nagoor Meeran, Khatija Ayoob, Seenipandi Arunachalam, Shreesh Ojha, Rami Beiram. Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms24129876. [PMID: 37373023]
  • Adeola Oluwatosin Adedara, Titilayomi A Otenaike, Oluwabukola M Farodoye, Amos Olalekan Abolaji. Ellagic acid mitigates rotenone-induced damage via modulating mitochondria function in Drosophila melanogaster. Journal of biochemical and molecular toxicology. 2023 Jun; 37(6):e23332. doi: 10.1002/jbt.23332. [PMID: 37294177]
  • Sadegh Moradi Vastegani, Seyed Esmaeil Khoshnam, Esrafil Mansouri, Samireh Ghafouri, Nima Bakhtiari, Yaghoob Farbood, Alireza Sarkaki. Anti-inflammatory, anti-apoptotic, and neuroprotective potentials of anethole in Parkinson's disease-like motor and non-motor symptoms induced by rotenone in rats. Metabolic brain disease. 2023 May; ?(?):. doi: 10.1007/s11011-023-01230-6. [PMID: 37204660]
  • Mahmoud A Desouky, Mina Y George, Haidy E Michel, Doaa A Elsherbiny. Roflumilast escalates α-synuclein aggregate degradation in rotenone-induced Parkinson's disease in rats: Modulation of the ubiquitin-proteasome system and endoplasmic reticulum stress. Chemico-biological interactions. 2023 Apr; 379(?):110491. doi: 10.1016/j.cbi.2023.110491. [PMID: 37105514]
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