Leucine (BioDeep_00000016679)

Main id: BioDeep_00000000246

Secondary id: BioDeep_00000229623

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


2-Amino-4-methylpentanoic acid

化学式: C6H13NO2 (131.0946)
中文名称: (±)-氨基-4-甲基戊酸, L-亮氨酸, DL-亮氨酸, L-白氨酸, 亮氨酸
谱图信息: 最多检出来源 Viridiplantae(plant) 8.65%

Reviewed

Last reviewed on 2024-07-08.

Cite this Page

Leucine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/leucine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000016679). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C)CC(C(=O)O)N
InChI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)

描述信息

A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.

Leucine (symbol Leu or L)[3] is an essential amino acid that is used in the biosynthesis of proteins. Leucine is an α-amino acid, meaning it contains an α-amino group (which is in the protonated −NH3+ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a side chain isobutyl group, making it a non-polar aliphatic amino acid. It is essential in humans, meaning the body cannot synthesize it: it must be obtained from the diet. Human dietary sources are foods that contain protein, such as meats, dairy products, soy products, and beans and other legumes. It is encoded by the codons UUA, UUG, CUU, CUC, CUA, and CUG. Leucine is named after the Greek word for "white": λευκός (leukós, "white"), after its common appearance as a white powder, a property it shares with many other amino acids.[4]

Like valine and isoleucine, leucine is a branched-chain amino acid. The primary metabolic end products of leucine metabolism are acetyl-CoA and acetoacetate; consequently, it is one of the two exclusively ketogenic amino acids, with lysine being the other.[5] It is the most important ketogenic amino acid in humans.[6]

Leucine and β-hydroxy β-methylbutyric acid, a minor leucine metabolite, exhibit pharmacological activity in humans and have been demonstrated to promote protein biosynthesis via the phosphorylation of the mechanistic target of rapamycin (mTOR).[7][8]
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

同义名列表

5 个代谢物同义名

Leucine; 2-Amino-4-methylpentanoic acid; L-Leucine; L-Leucine; Leucine



数据库引用编号

78 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

161 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 EGFR, GFAP, LNPEP, PRL, TNK1, TP53, ZMYND8
Peripheral membrane protein 2 ERVW-1, TNK1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, HSP90B1
Nucleus 6 EGFR, HSP90B1, JUN, PRL, TP53, ZMYND8
cytosol 5 GFAP, HSP90B1, LNPEP, PRKCQ, TP53
dendrite 1 PDYN
centrosome 1 TP53
nucleoplasm 4 JUN, PRL, TP53, ZMYND8
RNA polymerase II transcription regulator complex 2 JUN, PRL
Cell membrane 4 CD8A, EGFR, ITGAM, LNPEP
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 TPRA1
Synapse 1 PDYN
cell junction 1 EGFR
cell surface 2 EGFR, ITGAM
dendritic shaft 1 ZMYND8
glutamatergic synapse 1 EGFR
Golgi apparatus 1 NPY
Golgi membrane 1 EGFR
lysosomal membrane 1 LNPEP
neuronal cell body 1 PDYN
smooth endoplasmic reticulum 1 HSP90B1
endosome 1 EGFR
plasma membrane 12 CD8A, EGFR, ERVW-1, F2, GCG, IFNLR1, ITGAM, LNPEP, PDYN, PRKCQ, TNK1, TPRA1
Membrane 8 EGFR, HSP90B1, IFNLR1, ITGAM, LNPEP, TNK1, TP53, TPRA1
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 3 F2, HSP90B1, ITGAM
endoplasmic reticulum 2 HSP90B1, TP53
extracellular space 8 EGFR, F2, GCG, IL2, ITGAM, LNPEP, NPY, PRL
perinuclear region of cytoplasm 3 EGFR, HSP90B1, LNPEP
mitochondrion 1 TP53
protein-containing complex 3 EGFR, HSP90B1, TP53
Single-pass type I membrane protein 5 CD8A, EGFR, ERVW-1, IFNLR1, ITGAM
Secreted 6 F2, GCG, IL2, NPY, PDYN, PRL
extracellular region 8 CD8A, F2, GCG, HSP90B1, IL2, NPY, PDYN, PRL
astrocyte end-foot 1 GFAP
hippocampal mossy fiber to CA3 synapse 1 PDYN
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 JUN, TP53
centriolar satellite 1 PRKCQ
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
nuclear membrane 1 EGFR
external side of plasma membrane 2 CD8A, ITGAM
dendritic spine 1 ZMYND8
nucleolus 2 TP53, ZMYND8
midbody 1 HSP90B1
Single-pass type II membrane protein 1 LNPEP
Membrane raft 2 EGFR, ITGAM
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 EGFR, HSP90B1
GABA-ergic synapse 1 NPY
intracellular vesicle 1 EGFR
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 2 F2, HSP90B1
intermediate filament 1 GFAP
receptor complex 2 CD8A, EGFR
chromatin 4 JUN, PRL, TP53, ZMYND8
cell projection 1 GFAP
Chromosome 1 ZMYND8
nuclear chromosome 1 JUN
blood microparticle 1 F2
site of double-strand break 1 TP53
endosome lumen 1 PRL
Cytoplasmic vesicle membrane 1 LNPEP
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
Melanosome 1 HSP90B1
euchromatin 1 JUN
cell body 1 GFAP
germ cell nucleus 1 TP53
replication fork 1 TP53
sperm plasma membrane 1 HSP90B1
intermediate filament cytoskeleton 1 GFAP
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
plasma membrane raft 2 CD8A, ITGAM
secretory granule lumen 1 GCG
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 F2, GCG, HSP90B1
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
axon terminus 1 PDYN
immunological synapse 1 PRKCQ
neuronal dense core vesicle 2 NPY, PDYN
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 EGFR
Sarcoplasmic reticulum lumen 1 HSP90B1
[Isoform 1]: Nucleus 1 TP53
[Transmembrane protein]: Cell membrane 1 ERVW-1
[Surface protein]: Cell membrane 1 ERVW-1
[Isoform 1]: Cell membrane 1 CD8A
site of DNA damage 1 ZMYND8
integrin complex 1 ITGAM
cytoplasmic side of lysosomal membrane 1 GFAP
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 HSP90B1
transcription factor AP-1 complex 1 JUN
[Glucagon-like peptide 1]: Secreted 1 GCG
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
T cell receptor complex 1 CD8A
integrin alphaM-beta2 complex 1 ITGAM
endoplasmic reticulum chaperone complex 1 HSP90B1
early endosome lumen 1 LNPEP
interleukin-28 receptor complex 1 IFNLR1
[Syncytin-1]: Virion 1 ERVW-1


文献列表

  • Ai-Ai Chou, Chung-Hui Lin, Yen-Chen Chang, Hui-Wen Chang, Yi-Chen Lin, Chia-Chen Pi, Yao-Ming Kan, Hao-Fen Chuang, Hui-Wen Chen. Antiviral activity of Vigna radiata extract against feline coronavirus in vitro. The veterinary quarterly. 2024 Dec; 44(1):1-13. doi: 10.1080/01652176.2024.2349665. [PMID: 38712855]
  • Mihaly Mezei, Rauf Latif, Terry F Davies. The full-length TSH receptor is stabilized by TSH ligand. Journal of molecular graphics & modelling. 2024 06; 129(?):108725. doi: 10.1016/j.jmgm.2024.108725. [PMID: 38373379]
  • Lin Chen, Xin Wang, Yi Zou, Man-Cheng Tang. Genome Mining of a Fungal Polyketide Synthase-Nonribosomal Peptide Synthetase Hybrid Megasynthetase Pathway to Synthesize a Phytotoxic N-Acyl Amino Acid. Organic letters. 2024 May; 26(17):3597-3601. doi: 10.1021/acs.orglett.4c01039. [PMID: 38661293]
  • Yuguo Niu, Xiaoming Hu, Yali Song, Cunchuan Wang, Peixiang Luo, Shihong Ni, Fuxin Jiao, Ju Qiu, Weihong Jiang, Sheng Yang, Jun Chen, Rui Huang, Haizhou Jiang, Shanghai Chen, Qiwei Zhai, Jia Xiao, Feifan Guo. Blautia Coccoides is a Newly Identified Bacterium Increased by Leucine Deprivation and has a Novel Function in Improving Metabolic Disorders. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024 May; 11(18):e2309255. doi: 10.1002/advs.202309255. [PMID: 38429906]
  • David M Goldman, Cassandra B Warbeck, Micaela C Karlsen. Completely Plant-Based Diets That Meet Energy Requirements for Resistance Training Can Supply Enough Protein and Leucine to Maximize Hypertrophy and Strength in Male Bodybuilders: A Modeling Study. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081122. [PMID: 38674813]
  • Shu Zhang, Yuqin Huang, Changbing Zheng, Liyi Wang, Yanbing Zhou, Wentao Chen, Yehui Duan, Tizhong Shan. Leucine improves the growth performance, carcass traits, and lipid nutritional quality of pork in Shaziling pigs. Meat science. 2024 Apr; 210(?):109435. doi: 10.1016/j.meatsci.2024.109435. [PMID: 38246121]
  • Yujing Sun, Fan Liu, Mengzhu Zeng, Xinjie Zhang, Ying Cui, Zhaodan Chen, Lei Wang, Yuanpeng Xu, Jinbin Wu, Shengya Guo, Xian Dong, Suomeng Dong, Yan Wang, Yuanchao Wang. The ETI-dependent receptor-like kinase 1 positively regulates effector-triggered immunity by stabilizing NLR-required for cell death 4 in Nicotiana benthamiana. The New phytologist. 2024 Apr; 242(2):576-591. doi: 10.1111/nph.19596. [PMID: 38362937]
  • Xuewen Xu, Wei Wang, Yujiao Du, Ziyi Wang, Xueli Liu, Ming Tan, Xiaojian Lin, Jun Xu, Congxi Cai, Xiaohua Qi, Qiang Xu, Aimin Wei, Haipeng Fu, Shengli Du, Sally A Mackenzie, Yuhui Wang, Xuehao Chen, Xiaodong Yang. A single-nucleotide substitution in the leucine-rich-repeat-only gene CsLRR1 confers powdery mildew resistance in cucumber. Plant communications. 2024 Mar; 5(3):100774. doi: 10.1016/j.xplc.2023.100774. [PMID: 38018036]
  • María A Muñoz-Vargas, Jorge Taboada, Salvador González-Gordo, José M Palma, Francisco J Corpas. Characterization of leucine aminopeptidase (LAP) activity in sweet pepper fruits during ripening and its inhibition by nitration and reducing events. Plant cell reports. 2024 Mar; 43(4):92. doi: 10.1007/s00299-024-03179-x. [PMID: 38466441]
  • Vandana Sekhar, Houssine Ikhlef, Alexandra Bunea, Viet S Nguyen, Johan Joo, Mukund P Tantak, Holly Moots, Otto Phanstiel. The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress. Biomolecules. 2024 Mar; 14(3):. doi: 10.3390/biom14030326. [PMID: 38540746]
  • Yulin Yang, Shushu Wang, Chunxiang Sheng, Jialin Tan, Junmin Chen, Tianjiao Li, Xiaoqin Ma, Haipeng Sun, Xiao Wang, Libin Zhou. Branched-chain amino acid catabolic defect promotes α-cell proliferation via activating mTOR signaling. Molecular and cellular endocrinology. 2024 Mar; 582(?):112143. doi: 10.1016/j.mce.2023.112143. [PMID: 38158148]
  • Yen-Hua Huang, Zhihao Jiang, Qingdan Du, Kuok Yap, Aurélien Bigot, Quentin Kaas, Conan K Wang, David J Craik. Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1. The Journal of biological chemistry. 2024 Mar; 300(3):105682. doi: 10.1016/j.jbc.2024.105682. [PMID: 38272233]
  • Shujin Wang, Yinying Han, Ruimin Liu, Mengqian Hou, Dietbert Neumann, Jun Zhang, Fang Wang, Yumeng Li, Xueya Zhao, Francesco Schianchi, Chao Dai, Lizhong Liu, Miranda Nabben, Jan F C Glatz, Xin Wu, Xifeng Lu, Xi Li, Joost J F P Luiken. Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis. Circulation research. 2024 03; 134(5):505-525. doi: 10.1161/circresaha.123.322910. [PMID: 38422177]
  • Sarathadevi Rajendran, Patrick Silcock, Phil Bremer. Volatile Organic Compounds (VOCs) Produced by Levilactobacillus brevis WLP672 Fermentation in Defined Media Supplemented with Different Amino Acids. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040753. [PMID: 38398505]
  • Philippe J M Pinckaers, Michelle E G Weijzen, Lisanne H P Houben, Antoine H Zorenc, Imre W K Kouw, Lisette C P G M de Groot, Lex B Verdijk, Tim Snijders, Luc J C van Loon. The muscle protein synthetic response following corn protein ingestion does not differ from milk protein in healthy, young adults. Amino acids. 2024 Feb; 56(1):8. doi: 10.1007/s00726-023-03377-z. [PMID: 38315260]
  • Xiangyu Zhang, Divya Kapoor, Se-Jin Jeong, Alan Fappi, Jeremiah Stitham, Vasavi Shabrish, Ismail Sergin, Eman Yousif, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Arick Park, Arif Yurdagul, Oren Rom, Slava Epelman, Joel D Schilling, Marco Sardiello, Abhinav Diwan, Jaehyung Cho, Nathan O Stitziel, Ali Javaheri, Irfan J Lodhi, Bettina Mittendorfer, Babak Razani. Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk. Nature metabolism. 2024 Feb; 6(2):359-377. doi: 10.1038/s42255-024-00984-2. [PMID: 38409323]
  • Ayelen M Blanco, Femilarani Antomagesh, Sara Comesaña, Jose L Soengas, Mathilakath M Vijayan. Chronic cortisol-stimulation enhances hypothalamus-specific enrichment of metabolites in the rainbow trout brain. American journal of physiology. Endocrinology and metabolism. 2024 Jan; ?(?):. doi: 10.1152/ajpendo.00410.2023. [PMID: 38294699]
  • Jingwen Zhang, Mengtian Han, Shu Wang, Ruixia Wu, Qipeng Zhao, Meihua Chen, Yongmao Yang, Jing Zhang, Xianli Meng, Yi Zhang, Zhang Wang. Study on the anti-mitochondrial apoptosis mechanism of Erigeron breviscapus injection based on UPLC-Q-TOF-MS metabolomics and molecular docking in rats with cerebral ischemia-reperfusion injury. Journal of ethnopharmacology. 2024 Jan; 319(Pt 2):117310. doi: 10.1016/j.jep.2023.117310. [PMID: 37827296]
  • Bruce R Hoar, Holly B Ernest, Laura N L Johnson, Melanie E F LaCava, Douglas J Sandidge, Ken Gerow, Michelle R Mousel, Nathan L Galloway, William Swain, Jennifer L Malmberg. Ecology and Chronic Wasting Disease Epidemiology Shape Prion Protein Gene Variation in Rocky Mountain Elk (Cervus elaphus nelsoni). Journal of wildlife diseases. 2024 Jan; ?(?):. doi: 10.7589/jwd-d-23-00062. [PMID: 38287919]
  • Qiu-Hua Gu, Hao Xu, Xin Cao, Xi Cheng, Jun-Ya Jia, Tie-Kun Yan. The protease inhibitor E64d might attenuate the development of experimental anti-glomerular basement membrane disease through regulating the activation of Th1 cells. International immunopharmacology. 2024 Jan; 129(?):111594. doi: 10.1016/j.intimp.2024.111594. [PMID: 38295547]
  • Yuting Deng, Mengsi Hu, Shufang Huang, Nian Fu. Molecular mechanism and therapeutic significance of essential amino acids in metabolically associated fatty liver disease. The Journal of nutritional biochemistry. 2024 Jan; 126(?):109581. doi: 10.1016/j.jnutbio.2024.109581. [PMID: 38219809]
  • Anna Szuba-Trznadel, Anna Jama-Rodzeńska, Bernard Gałka, Rafał Ramut, Zygmunt Król, Daniel Jarki, Dragana Latković. The impact of the distribution method for struvite (Crystal Green) on the chemical composition of soybean and their utility in animal nutrition. Scientific reports. 2024 01; 14(1):1093. doi: 10.1038/s41598-024-51625-3. [PMID: 38212440]
  • Sergej Nadalin, Lena Zatković, Vjekoslav Peitl, Dalibor Karlović, Maja Vilibić, Ante Silić, Sanja Dević Pavlić, Alena Buretić-Tomljanović. An association between PPARα-L162V polymorphism and increased plasma LDL cholesterol levels after risperidone treatment. Prostaglandins, leukotrienes, and essential fatty acids. 2024 Jan; 200(?):102604. doi: 10.1016/j.plefa.2023.102604. [PMID: 38113727]
  • Haonan Yu, Yaorong Niu, Xinyu Lei, Chunlin Xie, Xianghua Yan. Multi-Omics Analysis Reveals Sphingomyelin Accumulation, Glycerolipids Loss, and Disorders of Lipid Metabolism Regulated by Leucine Deprivation in the Liver of Mice. Molecular nutrition & food research. 2024 Jan; 68(2):e2300567. doi: 10.1002/mnfr.202300567. [PMID: 38059795]
  • Hui Yang, Yan-Ru Liu, Zhong-Xing Song, Zhi-Shu Tang, Ai-Ling Jia, Ming-Geng Wang, Jin-Ao Duan. Study on the underlying mechanism of Poria in intervention of arrhythmia zebrafish by integrating metabolomics and network pharmacology. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155143. doi: 10.1016/j.phymed.2023.155143. [PMID: 37890443]
  • Peter Lüth, Henry Sila Nzioki, Claire Sands Baker, David Chandler Sands. A microbial bioherbicide for Striga hermonthica control: production, development, and effectiveness of a seed coating agent. Pest management science. 2024 Jan; 80(1):149-155. doi: 10.1002/ps.7522. [PMID: 37139834]
  • Jinxia Wu, Zhenchang Li, Hongwei Zhu, Yajie Chang, Quanquan Li, Jing Chen, Guiping Shen, Jianghua Feng. Childhood overweight and obesity: age stratification contributes to the differences in metabolic characteristics. Obesity (Silver Spring, Md.). 2023 Dec; ?(?):. doi: 10.1002/oby.23964. [PMID: 38112246]
  • Fanglei Xue, Zhen Zhao, Shuying Gu, Meixin Chen, Jing Xu, Xuegang Luo, Jingen Li, Chaoguang Tian. The transcriptional factor Clr-5 is involved in cellulose degradation through regulation of amino acid metabolism in Neurospora crassa. BMC biotechnology. 2023 11; 23(1):50. doi: 10.1186/s12896-023-00823-4. [PMID: 38031036]
  • Xinbo Zhou, Junjie Zhang, Jian Shen, Baojing Cheng, Chongpeng Bi, Qingquan Ma. Branched-chain amino acid modulation of lipid metabolism, gluconeogenesis, and inflammation in a finishing pig model: targeting leucine and valine. Food & function. 2023 Nov; 14(22):10119-10134. doi: 10.1039/d3fo03899h. [PMID: 37882496]
  • Boyoung Kim, Wenjia Yu, Haseong Kim, Qian Dong, Sera Choi, Maxim Prokchorchick, Alberto P Macho, Kee Hoon Sohn, Cécile Segonzac. A plasma membrane nucleotide-binding leucine-rich repeat receptor mediates the recognition of the Ralstonia pseudosolanacearum effector RipY in Nicotiana benthamiana. Plant communications. 2023 Nov; 4(6):100640. doi: 10.1016/j.xplc.2023.100640. [PMID: 37349986]
  • Jiangtao Huang, Jintao Li, Yong Ning, Yalun Ren, Yuexin Shao, Huawen Zhang, Xueyang Zong, Huaiping Shi. Enhancement of PPARα-Inhibited Leucine Metabolism-Stimulated β-Casein Synthesis and Fatty Acid Synthesis in Primary Bovine Mammary Epithelial Cells. Journal of agricultural and food chemistry. 2023 Nov; 71(43):16184-16193. doi: 10.1021/acs.jafc.3c00712. [PMID: 37853551]
  • Ya-Chi Kang, Shyi-Dong Yeh, Tsung-Chi Chen. Leucine 127 of cucurbit chlorotic yellows virus P22 is crucial for its RNA silencing suppression activity and pathogenicity. Phytopathology. 2023 Nov; ?(?):. doi: 10.1094/phyto-07-23-0227-r. [PMID: 37913633]
  • Haixiang Yu, Xuelian Wu, Jiahui Liang, Ziying Han, Yuansong Xiao, Hao Du, Yihua Liu, Jian Guo, Futian Peng. Genome-wide identification of nucleotide-binding domain leucine-rich repeat (NLR) genes and their association with green peach aphid (Myzus persicae) resistance in peach. BMC plant biology. 2023 Oct; 23(1):513. doi: 10.1186/s12870-023-04474-7. [PMID: 37880593]
  • Jarrett Man, T A Harrington, Kyra Lally, Madelaine E Bartlett. Asymmetric Evolution of Protein Domains in the Leucine-Rich Repeat Receptor-Like Kinase Family of Plant Signaling Proteins. Molecular biology and evolution. 2023 Oct; 40(10):. doi: 10.1093/molbev/msad220. [PMID: 37787619]
  • Junrey C Amas, Philipp E Bayer, Wei Hong Tan, Soodeh Tirnaz, William J W Thomas, David Edwards, Jacqueline Batley. Comparative pangenome analyses provide insights into the evolution of Brassica rapa resistance gene analogues (RGAs). Plant biotechnology journal. 2023 10; 21(10):2100-2112. doi: 10.1111/pbi.14116. [PMID: 37431308]
  • Haibin Jiang, Yeqiang Xia, Sicong Zhang, Zhichao Zhang, Hui Feng, Qi Zhang, Xi Chen, Junhua Xiao, Sen Yang, Mengzhu Zeng, Zhaodan Chen, Haibing Ouyang, Xinyi He, Guangzheng Sun, Jinbin Wu, Suomeng Dong, Wenwu Ye, Zhenchuan Ma, Yan Wang, Yuanchao Wang. The CAP superfamily protein PsCAP1 secreted by Phytophthora triggers immune responses in Nicotiana benthamiana through a leucine-rich repeat receptor-like protein. The New phytologist. 2023 10; 240(2):784-801. doi: 10.1111/nph.19194. [PMID: 37615219]
  • Jason S Shapiro, Hsiang-Chun Chang, Yuki Tatekoshi, Zibo Zhao, Zohra Sattar Waxali, Bong Jin Hong, Haimei Chen, Justin A Geier, Elizabeth T Bartom, Adam De Jesus, Farnaz K Nejad, Amir Mahmoodzadeh, Tatsuya Sato, Lucia Ramos-Alonso, Antonia Maria Romero, Maria Teresa Martinez-Pastor, Shang-Chuan Jiang, Shiv K Sah-Teli, Liming Li, David Bentrem, Gary Lopaschuk, Issam Ben-Sahra, Thomas V O'Halloran, Ali Shilatifard, Sergi Puig, Joy Bergelson, Peppi Koivunen, Hossein Ardehali. Iron drives anabolic metabolism through active histone demethylation and mTORC1. Nature cell biology. 2023 Oct; 25(10):1478-1494. doi: 10.1038/s41556-023-01225-6. [PMID: 37749225]
  • Khong-Sam Chia, Philip Carella. Taking the lead: NLR immune receptor N-terminal domains execute plant immune responses. The New phytologist. 2023 10; 240(2):496-501. doi: 10.1111/nph.19170. [PMID: 37525357]
  • Emma E Crean, Merle Bilstein-Schloemer, Takaki Maekawa, Paul Schulze-Lefert, Isabel M L Saur. A dominant-negative avirulence effector of the barley powdery mildew fungus provides mechanistic insight into barley MLA immune receptor activation. Journal of experimental botany. 2023 09; 74(18):5854-5869. doi: 10.1093/jxb/erad285. [PMID: 37474129]
  • Maïlys Piau, Corinne Schmitt-Keichinger. The Hypersensitive Response to Plant Viruses. Viruses. 2023 09; 15(10):. doi: 10.3390/v15102000. [PMID: 37896777]
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