Nicotine (BioDeep_00000000185)

 

Secondary id: BioDeep_00000229715, BioDeep_00000398739

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


(S)-(-)-NICOTINE; 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE

化学式: C10H14N2 (162.1156924)
中文名称: 烟碱, (+/-)-尼古丁, (-)-尼古丁
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.18%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Nicotine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/nicotine (retrieved 2024-11-25) (BioDeep RN: BioDeep_00000000185). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN(C2)C(CC2)c(c1)cncc1
InChI: InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3

描述信息

Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae), predominantly in tobacco and in lower quantities in tomato, potato, eggplant (aubergine), and green pepper. Nicotine alkaloids are also found in the leaves of the coca plant. Nicotine constitutes 0.3 to 5\\\% of the tobacco plant by dry weight, with biosynthesis taking place in the root and accumulation in the leaves. It is a potent neurotoxin with particular specificity to insects; therefore nicotine was widely used as an insecticide in the past and nicotine derivatives such as imidacloprid continue to be widely used. It has been noted that the majority of people diagnosed with schizophrenia smoke tobacco. Estimates for the number of schizophrenics that smoke range from 75\\\% to 90\\\%. It was recently argued that the increased level of smoking in schizophrenia may be due to a desire to self-medicate with nicotine. More recent research has found the reverse: it is a risk factor without long-term benefit, used only for its short-term effects. However, research on nicotine as administered through a patch or gum is ongoing. As nicotine enters the body, it is distributed quickly through the bloodstream and can cross the blood-brain barrier. On average, it takes about seven seconds for the substance to reach the brain. The half-life of nicotine in the body is around 2 hours. The amount of nicotine inhaled with tobacco smoke is a fraction of the amount contained in the tobacco leaves (most of the substance is destroyed by the heat). The amount of nicotine absorbed by the body from smoking depends on many factors, including the type of tobacco, whether the smoke is inhaled, and whether a filter is used. For chewing tobacco, often called dip, snuff, or sinus, which is held in the mouth between the lip and gum, the amount released into the body tends to be much greater than smoked tobacco. The currently available literature indicates that nicotine, on its own, does not promote the development of cancer in healthy tissue and has no mutagenic properties. Its teratogenic properties have not yet been adequately researched, and while the likelihood of birth defects caused by nicotine is believed to be very small or nonexistent, nicotine replacement product manufacturers recommend consultation with a physician before using a nicotine patch or nicotine gum while pregnant or nursing. However, nicotine and the increased acetylcholinic activity it causes have been shown to impede apoptosis, which is one of the methods by which the body destroys unwanted cells (programmed cell death). Since apoptosis helps to remove mutated or damaged cells that may eventually become cancerous, the inhibitory actions of nicotine create a more favourable environment for cancer to develop. Thus, nicotine plays an indirect role in carcinogenesis. It is also important to note that its addictive properties are often the primary motivating factor for tobacco smoking, contributing to the proliferation of cancer. Nicotine is a highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. Nicotine is a hygroscopic, oily liquid that is miscible with water in its base form. As a nitrogenous base, nicotine forms salts with acids that are usually solid and water soluble. Nicotine easily penetrates the skin. As shown by the physical data, free base nicotine will burn at a temperature below its boiling point, and its vapours will combust at 95 °C in the air despite a low vapour pressure. Because of this, most nicotine is burned when a cigarette is smoked; however, enough is inhaled to provide the desired effects. Nicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed of five homomeric or heteromeric subunits. In the brain, nicotine binds to nic...
Nicotine appears as a colorless to light yellow or brown liquid. Combustible. Toxic by inhalation and by skin absorption. Produces toxic oxides of nitrogen during combustion.
(S)-nicotine is a 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. It has a role as a phytogenic insecticide, a teratogenic agent, a neurotoxin, an anxiolytic drug, a nicotinic acetylcholine receptor agonist, a biomarker, an immunomodulator, a mitogen, a peripheral nervous system drug, a psychotropic drug, a plant metabolite and a xenobiotic. It is a conjugate base of a (S)-nicotinium(1+). It is an enantiomer of a (R)-nicotine.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Nicotine is a Cholinergic Nicotinic Agonist.
Nicotine is a natural alkyloid that is a major component of cigarettes and is used therapeutically to help with smoking cessation. Nicotine has not been associated with liver test abnormalities or with clinically apparent hepatotoxicity.
Nicotine is a natural product found in Cyphanthera tasmanica, Nicotiana cavicola, and other organisms with data available.
Nicotine is a plant alkaloid, found in the tobacco plant, and addictive central nervous system (CNS) stimulant that causes either ganglionic stimulation in low doses or ganglionic blockage in high doses. Nicotine acts as an agonist at the nicotinic cholinergic receptors in the autonomic ganglia, at neuromuscular junctions, and in the adrenal medulla and the brain. Nicotines CNS-stimulating activities may be mediated through the release of several neurotransmitters, including acetylcholine, beta-endorphin, dopamine, norepinephrine, serotonin, and ACTH. As a result, peripheral vasoconstriction, tachycardia, and elevated blood pressure may be observed with nicotine intake. This agent may also stimulate the chemoreceptor trigger zone, thereby inducing nausea and vomiting.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
See also: Tobacco Leaf (part of); Nicotine Polacrilex (related); Menthol; nicotine (component of) ... View More ...
Alkaloid from Nicotiana tabacum and other Nicotiana subspecies, Asclepias syriaca, Lycopodium subspecies, and other subspecies (Solanaceae, Asclepiadaceae, Crassulaceae). Rare spread of occurrence between angiosperms and cryptogametes (CCD)
A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.

同义名列表

244 个代谢物同义名

(S)-(-)-NICOTINE; 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE; Pyridine, 3-(tetrahydro-1-methylpyrrol-2-yl), (S)-; (-)-Nicotine, PESTANAL(R), analytical standard; (-)-.beta.-Pyridyl-.alpha.-N-methylpyrrolidine; PYRIDINE, 3-(TETRAHYDRO-1-METHYL PYRROL-2-YL); Pyridine, 3-(tetrahydro-1-methylpyrrol-2-yl); Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-,(S)-; Pyridine, 3-[(2S)-1-methyl-2-pyrrolidinyl]-; (2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine; Nicotac Nicotine PolacrilexCoated Cinnamon; 3-((2S)-1-METHYL-2-PYRROLIDINYL)PYRIDINE; 3-((2S)-1-methylpyrrolidin-2-yl)pyridine; LEADER NICOTINE TRANSDERMAL SYSTEMSTEP 2; LEADER NICOTINE TRANSDERMAL SYSTEMSTEP 1; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine; LEADER NICOTINE TRANSDERMAL SYSTEMSTEP 3; (S)-3-(N-methylpyrrolidin-2-yl)pyridine; (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine; (R)-3-(1-Methyl-2-pyrrolidinyl)pyridine; beta-Pyridyl-alpha-N-methyl pyrrolidine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; beta-Pyridyl-alpha-N-methylpyrrolidine; Nicotac Nicotine PolacrilexCoated Mint; (-)-1-Methyl-2-(3-pyridyl)pyrrolidine; (-)-3-(1-Methyl-2-pyrrolidyl)pyridine; PYRROLIDENE, 1-METHYL-2-(3-PYRIDAL)-; NICOTINE PREPARATION, LIQUID, N.O.S.; Pyrrolidine, 1-methyl-2-(3-pyridyl)-; Pyrrolidine, 1-methyl-2-(3-pyridal)-; 3-(1-methyl-2-pyrrolidinyl)-Pyridine; good neighbor pharmacy nicotine mini; 3-(2-(N-methylpyrrolidinyl))pyridine; 3-(1-Methyl-2-pyrollidinyl)pyridine; L-3-(1-Methyl-2-pyrrolidyl)pyridine; 3-(1-methylpyrrolidin-2-yl)pyridine; Good Sense NicotineStop Smoking Aid; 3-(1-Methyl-2-pyrrolidinyl)pyridine; (-)-3-(N-Methylpyrrolidino)pyridine; 1-Methyl-2-(3-pyridiyl)pyrrolidine; Nicotine Polacrilexcoated cinnamon; Nicotine PolacrilexOrigianl Flavor; 1-methyl-2-(3-pyridal)-pyrrolidene; 1-methyl-2-(3-pyridal)-Pyrrolidine; Nicotine PolacrilexCoated Ice Mint; Nicotine PolacrilexOriginal Flavor; NICOTINE COMPOUND, LIQUID, N.O.S.; NICOTINETransdermal System Step 3; Nicotine Transdermal System Patch; NICOTINETransdermal System Step 1; Nicotine Transdermal SystemStep 1; Nicotine Transdermal SystemStep 2; (-)-Nicotine, >=99\\% (GC), liquid; Nicotinetransdermal system step 2; 1-Methyl-2-(3-pyridyl)pyrrolidine; Nicotine Transdermal SystemStep 3; Nicotine 10 microg/mL in Methanol; 3-(1-Methyl-2-pyrrolidyl)pyridine; 3-(N-Methylpyrrolidino)pyridine; Good Neighbor Pharmacy Nicotine; Habitrol LozengeOriginal Flavor; l-Nicotine, 50mg/ml in Methanol; l-Nicotine, 10mg/ml in Methanol; 3-(N-Methylpyrollidino)pyridine; NICOTINE COMPONENT OF NICORETTE; Nicotine Polacrilexcoated mint; l-Nicotine, 1mg/ml in Methanol; methyl-2-pyrrolidinyl)pyridine; NICOTINE COMPONENT OF COMMIT; Berkley and Jensen Nicotine; Nicotine Polacrilexoriginal; Kirkland Signature Nicotine; Nicotine polacrilex [USAN]; foster and thrive nicotine; Members Mark Mini Nicotine; Nicotinetransdermal system; Nicotine [for single use]; Kirkland Signature Quit 2; Kirkland Signature Quit 4; alpha-N-methylpyrrolidine; S-()-Nicotine-pyridine-d4; exchange select nicotine; Nicotine COATED ice mint; NICOTINE [USP MONOGRAPH]; NicoretteSpearmint Burst; NICOTINE (USP MONOGRAPH); family wellness nicotine; basic care nicotine mini; DL-tetrahydronicotyrine; NicoretteCinnamon Surge; Nicotine PolacrilexMINT; good sense nicotinemint; Signature Care Nicotine; NICOTINE (EP MONOGRAPH); NICOTINE [EP MONOGRAPH]; up and up mini nicotine; NicoretteWhite Ice Mint; Ortho N-4 and N-5 dusts; NICOTINE [ORANGE BOOK]; a -N-methylpyrrolidine; Harris Teeter Nicotine; Habitrol LozengeCherry; Destruxol orchid spray; a-N-methylpyrrolidine; Nicotine-D salicylate; 3-N-methylpyrrolidine; Members Mark Nicotine; Health Mart Nicotine; Bitartrate, nicotine; NicoretteFruit Chill; Topcare Nicotine Gum; Nicotine Bitartrate; Nicotinetransdermal; Campbells nico-soap; Basic Care Nicotine; Good Sense Nicotine; Nicotine polacrilex; NicoretteFresh Mint; nicotinemint flavor; Tartrate, nicotine; NICOTINE, (LIQUID); Up and Up Nicotine; Nicotine [USP:BAN]; Nicotina [Italian]; DG Health nicotine; XL All Insecticide; Nicotine [BSI:ISO]; NicotineSugar Free; Nicotine (USP:BAN); Nicotine polarilex; Care One Nicotine; Equaline Nicotine; NicoretteOriginal; Niagara P.A. dust; Nicotine Tartrate; NICOTINE-L (BASE); Nikotyna [Polish]; Nicotine alkaloid; NICOTINE [WHO-DD]; 2-beta-H-Nicotine; (S)-(-)--nicotine; NICOTINUM [HPUS]; Sunmark Nicotine; (S)-(-)-Nicotine; NICOTINE [VANDF]; Nikotin [German]; Nicotine betadex; NICOTINE [MART.]; Nicotrol Inhaler; Careone Nicotine; Stop Smoking Aid; Topcare Nicotine; NICOTINE (MART.); Habitrol Lozenge; Rexall Nicotine; NIAGARA PA DUST; NICOTINE [HSDB]; Leader Nicotine; Equate Nicotine; R)-(+)-nicotine; euqate nicotine; UNII-6M3C89ZY6R; L-(-)-Nicotine; HabitrolStep 2; Nicotine (USP); Ortho N-5 dust; S-(-)-Nicotine; delta-Nicotine; (R,S)-Nicotine; HabitrolStep 3; Ortho N-4 dust; Nicotine [ISO]; HabitrolStep 1; bjwc nicotine; Nicotine Mini; Maxi Nicotine; Nicorette gum; NicoretteMint; Habitrol (TN); NICOTINE [MI]; Lucy nicotine; Mini Nicotine; L(-)-nicotine; nicotine s(-); nictoine gum; Tox21_300174; (-)-Nicotine; PDSP1_000113; Tox21_201814; PDSP2_000463; PDSP1_000465; PDSP2_000555; (S)-Nicotine; NicotineMini; (+)-Nicotine; HEB Nicotine; Nicotrol NS; CAS-54-11-5; Nicoderm Cq; D-Nicotine; Good Sense; 6M3C89ZY6R; Nicotinum,; L-Nicotine; fumeto bac; NICODERMCQ; Nicorelief; Nico-Fume; AI3-03424; destruxol; Fumetobac; Nicotinum; Flux MAAG; Nico-dust; Nicorette; ENT 3,424; Nicotine; Nicocide; Nicotrol; Nikotyna; Nicotina; Nicoderm; Micotine; Habitrol; Mach-Nic; Niquitin; Nicabate; TEN DUST; Emo-nik; Prostep; CHEMBL3; Nic-Sal; MACHNIC; Nikotin; Tabazur; Tendust; Nicotin; Exodus; blip; 1uw6; (±)-nicotine; Nicotine; (R,S)-Nicotine



数据库引用编号

45 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

279 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xuemei Wang, Junaid Zafar, Xiaotong Yang, Surajit De Mandal, Yingying Hong, Fengliang Jin, Xiaoxia Xu. Gut bacterium Burkholderia cepacia (BsNLG8) and immune gene Defensin A contribute to the resistance against Nicotine-induced stress in Nilaparvata lugens (Stål). Ecotoxicology and environmental safety. 2024 Jun; 277(?):116371. doi: 10.1016/j.ecoenv.2024.116371. [PMID: 38663196]
  • Kimberly N Karin, Mohammed A Mustafa, Justin L Poklis, Belle Buzzi, Joel E Schlosburg, Linda Parker, M Imad Damaj, Aron H Lichtman. N-oleoyl alanine attenuates nicotine reward and spontaneous nicotine withdrawal in mice. Drug and alcohol dependence. 2024 Jun; 259(?):111276. doi: 10.1016/j.drugalcdep.2024.111276. [PMID: 38676968]
  • Huiqi Zong, Zhekai Hu, Weina Li, Mina Wang, Qi Zhou, Xiang Li, Hongxu Liu. Electronic cigarettes and cardiovascular disease: epidemiological and biological links. Pflugers Archiv : European journal of physiology. 2024 Jun; 476(6):875-888. doi: 10.1007/s00424-024-02925-0. [PMID: 38376568]
  • Nikolina Kastratovic, Vladimir Markovic, Carl Randall Harrell, Aleksandar Arsenijevic, Milica Dimitrijevic Stojanovic, Valentin Djonov, Vladislav Volarevic. Effects of Combustible Cigarettes and Electronic Nicotine Delivery Systems on the Development and Progression of Chronic Lung Inflammation in Mice. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2024 May; 26(6):704-714. doi: 10.1093/ntr/ntad235. [PMID: 38018885]
  • Nour M Hammad, Julia A Wolfson, Sarah D de Ferranti, Walter C Willett, Cindy W Leung. Food Insecurity and Ideal Cardiovascular Health Risk Factors Among US Adolescents. Journal of the American Heart Association. 2024 Apr; 13(8):e033323. doi: 10.1161/jaha.123.033323. [PMID: 38591328]
  • S K Johnsy Sugitha, Raja Venkatesan, R Gladis Latha, Alexandre A Vetcher, Bandar Ali Al-Asbahi, Seong-Cheol Kim. A Study on the Antibacterial, Antispasmodic, Antipyretic, and Anti-Inflammatory Activity of ZnO Nanoparticles Using Leaf Extract from Jasminum sambac (L. Aiton). Molecules (Basel, Switzerland). 2024 Mar; 29(7):. doi: 10.3390/molecules29071464. [PMID: 38611744]
  • Tsubasa Shoji, Takashi Hashimoto, Kazuki Saito. Genetic regulation and manipulation of nicotine biosynthesis in tobacco: strategies to eliminate addictive alkaloids. Journal of experimental botany. 2024 Mar; 75(6):1741-1753. doi: 10.1093/jxb/erad341. [PMID: 37647764]
  • Hari Pradhyumnan, Shahil H Patel, Ofelia Furones-Alonso, Weizhao Zhao, Helen M Bramlett, Ami P Raval. Electronic Cigarette Vape Exposure Exacerbates Post-Ischemic Outcomes in Female but Not in Male Rats. Stroke. 2024 Mar; 55(3):735-746. doi: 10.1161/strokeaha.123.046101. [PMID: 38323450]
  • Qiang Li, Jingtan Li, Jingting Wang, Jing Wang, Tong Lu, Yanfei Jia, Haiji Sun, Xiaoli Ma. PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma. Molecular carcinogenesis. 2024 Feb; 63(2):253-265. doi: 10.1002/mc.23649. [PMID: 37921560]
  • Hyun Jun Lee, Darlene Mae Ortiz, Leandro Val Sayson, Mikyung Kim, Jae Hoon Cheong, Hee Jin Kim. Ameliorating effects of Acanthopanax koreanum extract and components on nicotine dependence and withdrawal symptoms. Addiction biology. 2024 Feb; 29(2):e13360. doi: 10.1111/adb.13360. [PMID: 38380695]
  • Shambhavi Dwivedi, Deeksha Singh, Nivedita Singh, Prabodh Kumar Trivedi. Advances in regulatory mechanism(s) and biotechnological approaches to modulate nicotine content in tobacco. Plant physiology and biochemistry : PPB. 2024 Jan; 207(?):108397. doi: 10.1016/j.plaphy.2024.108397. [PMID: 38316099]
  • K Xiao, P S Xu, H Lin. [Research progress on the prevalence and harm of heated tobacco products]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. 2024 Jan; 47(1):64-69. doi: 10.3760/cma.j.cn112147-20230812-00072. [PMID: 38062698]
  • Adam Pym, Bartlomiej J Troczka, Angela Hayward, Bin Zeng, Cong-Fen Gao, Jan Elias, Russell Slater, Christoph T Zimmer, Chris Bass. The role of the Bemisia tabaci and Trialeurodes vaporariorum cytochrome-P450 clade CYP6DPx in resistance to nicotine and neonicotinoids. Pesticide biochemistry and physiology. 2024 Jan; 198(?):105743. doi: 10.1016/j.pestbp.2023.105743. [PMID: 38225086]
  • Abdullahi Adejare, A K Oloyo, I O Ishola, A A Busari, K B Ismail-Badmus, M M Abdulrazaq, O O Osifala, M O Salami. Brain antioxidant status and gene expressions of nicotinic and dopamine receptors are improved by black seed oil administration in cigarette smoke or nicotine vapour-exposed rats. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2023 Dec; 38(2):157-169. doi: 10.54548/njps.v38i2.5. [PMID: 38696688]
  • Naiyan Lu, Xue Mei, Xu Li, Xue Tang, Guofeng Yang, Wen Xiang. Preventive effects of caffeine on nicotine plus high-fat diet-induced hepatic steatosis and gain weight: a possible explanation for why obese smokers with high coffee consumption tend to be leaner. The British journal of nutrition. 2023 Dec; ?(?):1-10. doi: 10.1017/s0007114523002969. [PMID: 38149470]
  • Deeksha Singh, Shambhavi Dwivedi, Hiteshwari Sinha, Nivedita Singh, Prabodh Kumar Trivedi. Mutation in shoot-to-root mobile transcription factor, ELONGATED HYPOCOTYL 5, leads to low nicotine levels in tobacco. Journal of hazardous materials. 2023 Dec; 465(?):133255. doi: 10.1016/j.jhazmat.2023.133255. [PMID: 38103287]
  • Yunpeng Ge, Yitian Liu, Bo Ji, Yang Fang, Yana Xie, Reiko Sakurai, Jiajia Wang, Ziyue Zhang, Yifei Wang, Xu Wang, Virender K Rehan. Evidence for Wnt signaling's central involvement in perinatal nicotine exposure-induced offspring lung pathology and its modulation by electroacupuncture. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115824. doi: 10.1016/j.biopha.2023.115824. [PMID: 37925937]
  • Shiyang Song, Yaqi Wang, Jin Wang, Yanfang Liu, Xingzi Zhang, Aiguo Yang, Fengxia Li. Low H3K27me3 deposition at CYP82E4 determines the nicotinic conversion rate in Nicotiana tabacum. Plant physiology and biochemistry : PPB. 2023 Nov; 206(?):108234. doi: 10.1016/j.plaphy.2023.108234. [PMID: 38056040]
  • Marie-Lise Colsoul, Nicolas Goderniaux, Sabrina Onorati, Stéphanie Dupuis, Jacques Jamart, Dominique Vanpee, Ivan Berlin, Laurence Galanti. Effect of the Nicotine Replacement Therapy on Biomarkers of Inflammation, Endothelial Dysfunction, Oxidative Stress, and Lipids in Smokers Who Quit Smoking. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2023 Nov; 25(12):1875-1881. doi: 10.1093/ntr/ntad130. [PMID: 37498228]
  • Muhammad Jahangeer, Ghulam Mustafa, Naveed Munir, Sibtain Ahmed, Khalid Mashai Al-Anazi. Exploring the Potential of Plant Bioactive Compounds against Male Infertility: An In Silico and In Vivo Study. Molecules (Basel, Switzerland). 2023 Nov; 28(23):. doi: 10.3390/molecules28237693. [PMID: 38067423]
  • Ünal Öztekin, Mehmet Caniklioğlu, Şükrü Ateş, Züleyha Doğanyiğit, Emin Kaymak, Fatih Fırat, Ayşe Yeşim Göçmen, Fatih Ataç, Rukset Attar, Seher Yılmaz. The effect of Cornus mas extract on nıcotıne-ınduced oxıdatıve stress and ıntratestıcular damage ın male rats. Cellular and molecular biology (Noisy-le-Grand, France). 2023 Nov; 69(11):246-253. doi: 10.14715/cmb/2023.69.11.37. [PMID: 38015512]
  • Spenser Waller, Avery Powell, Randi Noel, Michael J Schueller, Richard A Ferrieri. Radiocarbon Flux Measurements Reveal Mechanistic Insight into Heat-Stress Induction of Nicotine Biosynthesis in Nicotiana attenuata. International journal of molecular sciences. 2023 Oct; 24(21):. doi: 10.3390/ijms242115509. [PMID: 37958493]
  • Katharina Vollheyde, Quentin M Dudley, Ting Yang, Mehmet T Oz, Davide Mancinotti, Mariano Olivera Fedi, Darren Heavens, Gareth Linsmith, Monika Chhetry, Mark A Smedley, Wendy A Harwood, David Swarbreck, Fernando Geu-Flores, Nicola J Patron. An improved Nicotiana benthamiana bioproduction chassis provides novel insights into nicotine biosynthesis. The New phytologist. 2023 10; 240(1):302-317. doi: 10.1111/nph.19141. [PMID: 37488711]
  • Luana Lopes Souza, Camila Lüdke Rossetti, Thamara Cherem Peixoto, Alex Christian Manhães, Egberto Gaspar de Moura, Patrícia Cristina Lisboa. Neonatal nicotine exposure affects adult rat hepatic pathways involved in endoplasmic reticulum stress and macroautophagy in a sex-dependent manner. Journal of developmental origins of health and disease. 2023 Oct; 14(5):639-647. doi: 10.1017/s2040174423000326. [PMID: 38037831]
  • Gu Gong, Yingying Hong, Xuemei Wang, Surajit De Mandal, Junaid Zafar, Ling Huang, Fengliang Jin, Xiaoxia Xu. Nicotine perturbs the microbiota of brown planthopper (Nilaparvata lugens stål Hemiptera: Delphinidae). Ecotoxicology and environmental safety. 2023 Oct; 264(?):115383. doi: 10.1016/j.ecoenv.2023.115383. [PMID: 37634480]
  • Min Li, Gang Li, Yanyan Yang, Jinbao Zong, Xiuxiu Fu, Aung Lynn Htet Htet, Xiaolu Li, Tianxiang Li, Jianxun Wang, Tao Yu. piRNA-823 is a novel potential therapeutic target in aortic dissection. Pharmacological research. 2023 Oct; 196(?):106932. doi: 10.1016/j.phrs.2023.106932. [PMID: 37739144]
  • Guiyu Kang, Yang Jiao, Pan Pan, Huiping Fan, Qiang Li, Xiangying Li, Jingtan Li, Yan Wang, Yanfei Jia, Jingting Wang, Haiji Sun, Xiaoli Ma. α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape. Carcinogenesis. 2023 Sep; ?(?):. doi: 10.1093/carcin/bgad061. [PMID: 37681453]
  • Kacper Piotr Kaminski, Lucien Bovet, Aurore Hilfiker, Helene Laparra, Joanne Schwaar, Nicolas Sierro, Gerhard Lang, Damien De Palo, Philippe Alexandre Guy, Csaba Laszlo, Simon Goepfert, Nikolai V Ivanov. Suppression of pyrrolidine ring biosynthesis and its effects on gene expression and subsequent accumulation of anatabine in leaves of tobacco (N. tabacum L.). BMC genomics. 2023 Sep; 24(1):516. doi: 10.1186/s12864-023-09588-8. [PMID: 37667170]
  • Xin Hou, Sanjay Kumar Singh, Joshua R Werkman, Yongliang Liu, Qinghua Yuan, Xia Wu, Barunava Patra, Xueyi Sui, Ruiqing Lyu, Bingwu Wang, Xiaoyu Liu, Yongqing Li, Wei Ma, Sitakanta Pattanaik, Ling Yuan. Partial desensitization of MYC2 transcription factor alters the interaction with jasmonate signaling components and affects specialized metabolism. International journal of biological macromolecules. 2023 Aug; ?(?):126472. doi: 10.1016/j.ijbiomac.2023.126472. [PMID: 37625752]
  • Wojciech Świątkowski, Barbara Budzyńska, Monika Maciąg, Agnieszka Świątkowska, Przemko Tylżanowski, Mansur Rahnama-Hezavah, Piotr Stachurski, Renata Chałas. Nicotine and Cytisine Embryotoxicity in the Experimental Zebrafish Model. International journal of molecular sciences. 2023 Jul; 24(15):. doi: 10.3390/ijms241512094. [PMID: 37569468]
  • Nancy A Rigotti, Neal L Benowitz, Judith Prochaska, Scott Leischow, Mitchell Nides, Brent Blumenstein, Anthony Clarke, Daniel Cain, Cindy Jacobs. Cytisinicline for Smoking Cessation: A Randomized Clinical Trial. JAMA. 2023 07; 330(2):152-160. doi: 10.1001/jama.2023.10042. [PMID: 37432430]
  • Wael Ammar Aldaddou, Abdullah S M Aljohani, Idris Adewale Ahmed, Naser A Al-Wabel, Ibrahim M El-Ashmawy. Salvia officinalis L. Methanolic Extract Reduces Lead and Nicotine-Induced Sperm Quality Degeneration in Male Rats. Chemistry & biodiversity. 2023 Jul; 20(7):e202300115. doi: 10.1002/cbdv.202300115. [PMID: 37236909]
  • Xiaohong Li, Yimeng Shi, XuanXuan Lin, Zhezhi Li, Jiawei Xiao, Xianjun Yang. Effects of wild, local, and cultivated tobacco varieties on the performance of Spodoptera litura and its parasitoid Meteorus pulchricornis. Pest management science. 2023 Jul; 79(7):2390-2396. doi: 10.1002/ps.7416. [PMID: 36802371]
  • Shengzhe Ji, Zhen Liu, Peng Liu. Effects of the grade/price and thickness of cigarette on the PM2.5 concentration of smoke. Environmental science and pollution research international. 2023 Jun; 30(27):71409-71414. doi: 10.1007/s11356-023-27610-0. [PMID: 37204582]
  • Elsa T Roxlau, Oleg Pak, Stefan Hadzic, Claudia F Garcia-Castro, Marija Gredic, Cheng-Yu Wu, Julia Schäffer, Balachandar Selvakumar, Alexandra Pichl, David Spiegelberg, Janik Deutscher, Mariola Bednorz, Katharina Schäfer, Simone Kraut, Djuro Kosanovic, Esraa M Zeidan, Baktybek Kojonazarov, Susanne Herold, Ievgen Strielkov, Andreas Guenther, Jochen Wilhelm, Mohamed M A Khalifa, Ashraf Taye, Ralf P Brandes, Matthias Hecker, Friedrich Grimminger, Hossein A Ghofrani, Ralph T Schermuly, Werner Seeger, Natascha Sommer, Norbert Weissmann. Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations. The European respiratory journal. 2023 06; 61(6):. doi: 10.1183/13993003.00951-2022. [PMID: 37105573]
  • Zhen-Yu Liu, Shu-Min Chen, Jin Chang, Ying-Ying Wang, Jin-Sheng Yang. [Acupuncture for treatment of tobacco withdrawal syndrome: systematic review and Meta-analysis]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2023 May; 43(5):575-83. doi: doi:10.13703/j.0255-2930.20220423-k0002. [PMID: 37161812]
  • - Sumaiya Binte Hamid, - Humaira Sharif, - Faiza Sajid, - Samina Bano. Differential effects of chronic nicotine administration on markers of oxidative stress and cellular damage in male and female rats. Pakistan journal of pharmaceutical sciences. 2023 May; 36(3):811-818. doi: . [PMID: 37580930]
  • Nicholas J Day, Juan Wang, Carl J Johnston, So-Young Kim, Heather M Olson, Emma L House, Isaac Kwame Attah, Geremy C Clair, Wei-Jun Qian, Matthew D McGraw. Rat bronchoalveolar lavage proteome changes following e-cigarette aerosol exposures. American journal of physiology. Lung cellular and molecular physiology. 2023 05; 324(5):L571-L583. doi: 10.1152/ajplung.00016.2023. [PMID: 36881561]
  • Garishma Shah, Upma Bhatt, Vineet Soni. Cigarette: an unsung anthropogenic evil in the environment. Environmental science and pollution research international. 2023 May; 30(21):59151-59162. doi: 10.1007/s11356-023-26867-9. [PMID: 37055684]
  • Zelin Zhang, Jianyong Cheng, Li Yang, Xiaoya Li, Rongmao Hua, Dejun Xu, Zhongliang Jiang, Qingwang Li. The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity. Free radical biology & medicine. 2023 05; 200(?):26-35. doi: 10.1016/j.freeradbiomed.2023.02.024. [PMID: 36893944]
  • Yuan Longyu, Qichang Liang, Yanfang Li, Yangsuo Dai, Jianmei Shen, Liming Hu, Hanxiang Xiao, Zhenfei Zhang. Nicotine-mediated dopamine regulates short neuropeptide F to inhibit brown planthopper feeding behavior in tobacco-rice rotation cropping. Pest management science. 2023 Mar; ?(?):. doi: 10.1002/ps.7474. [PMID: 36966467]
  • Taja Verovšek, Ariana Šuštarič, Maria Laimou-Geraniou, Ivona Krizman-Matasic, Helena Prosen, Tina Eleršek, Vlasta Kramarič Zidar, Vesna Mislej, Boštjan Mišmaš, Marjeta Stražar, Marjetka Levstek, Bernardka Cimrmančič, Simon Lukšič, Nataša Uranjek, Tjaša Kozlovič-Bobič, Tina Kosjek, David Kocman, David Heath, Ester Heath. Removal of residues of psychoactive substances during wastewater treatment, their occurrence in receiving river waters and environmental risk assessment. The Science of the total environment. 2023 Mar; 866(?):161257. doi: 10.1016/j.scitotenv.2022.161257. [PMID: 36608822]
  • Xiaojiang Qin, Xiaomin Hou, Xinrong Xu, Liangjin Chen, Anqi Gao, Yuxuan Hao, Xufeng Du, Liangyuan Zhao, Yiwei Shi, Qingshan Li. Down-regulation of connexin 43 contributes to structure and function of pulmonary artery in nicotine-administered mice. Toxicology letters. 2023 Mar; 377(?):1-13. doi: 10.1016/j.toxlet.2023.01.008. [PMID: 36720419]
  • Jianyi Li, Yuntong Lv, Yajing Liu, Rui Bi, Yiou Pan, Qingli Shang. Inducible Gut-Specific Carboxylesterase SlCOE030 in Polyphagous Pests of Spodoptera litura Conferring Tolerance between Nicotine and Cyantraniliprole. Journal of agricultural and food chemistry. 2023 Mar; 71(10):4281-4291. doi: 10.1021/acs.jafc.3c00524. [PMID: 36877657]
  • Yun-Chung Hsiao, Richard S Matulewicz, Scott E Sherman, Ilona Jaspers, Michael L Weitzman, Terry Gordon, Chih-Wei Liu, Yifei Yang, Kun Lu, Marc A Bjurlin. Untargeted Metabolomics to Characterize the Urinary Chemical Landscape of E-Cigarette Users. Chemical research in toxicology. 2023 Mar; ?(?):. doi: 10.1021/acs.chemrestox.2c00346. [PMID: 36912507]
  • Stephanie Johne, Marco van der Toorn, Anita R Iskandar, Shoaib Majeed, Laura O Torres, Julia Hoeng, Manuel C Peitsch. An in vitro evaluation of e-vapor products: The contributions of chemical adulteration, concentration, and device power. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Mar; 175(?):113708. doi: 10.1016/j.fct.2023.113708. [PMID: 36889430]
  • Yun-Fei Sha, Jun-Wei Xiong, Yu-Lin Zhai, Bao-Lei Wang, Zhi-Hua Zhong, Ting Fei, Du-Xin Li, Da Wu. [Trapping array-based preparative two-dimensional liquid chromatography for the purification of four components in tobacco leaves]. Se pu = Chinese journal of chromatography. 2023 Mar; 41(3):281-286. doi: 10.3724/sp.j.1123.2022.08021. [PMID: 36861212]
  • Haroun Nacera, Hamdis Nacim, Arab Medina, Aouichat-Bouguerra Souhila. Effect of green tea and nicotine on haematological and biochemical parameters and histopathology of bone marrow and spleen on albino rats. Pakistan journal of pharmaceutical sciences. 2023 Mar; 36(2):387-395. doi: . [PMID: 37530145]
  • Feng-Li Li, Xin Chen, Hui-Min Luo, Scott J Meiners, Chui-Hua Kong. Root-secreted (-)-loliolide modulates both belowground defense and aboveground flowering in Arabidopsis and tobacco. Journal of experimental botany. 2023 02; 74(3):964-975. doi: 10.1093/jxb/erac439. [PMID: 36342376]
  • Rahul Jain, Priyanka Bhardwaj, Shweta Guleria, Anita Pandey, Sanjay Kumar. Polyamine metabolizing rhizobacteria Pseudomonas sp. GBPI_506 modulates hormone signaling to enhance lateral roots and nicotine biosynthesis in Nicotiana benthamiana. Plant physiology and biochemistry : PPB. 2023 Feb; 195(?):193-205. doi: 10.1016/j.plaphy.2023.01.010. [PMID: 36641943]
  • Lu Liu, Jiajun Wei, Yong Wang, Quan Feng, Shugang Guo, Gaisheng Liu, Jun Dong, Liuquan Jiang, Qiang Li, Jisheng Nie, Jin Yang. Effect of Club cell secretory proteins on the association of tobacco smoke and PAH co-exposure with lung function decline: A longitudinal observation of Chinese coke oven workers. International journal of hygiene and environmental health. 2023 01; 247(?):114058. doi: 10.1016/j.ijheh.2022.114058. [PMID: 36334377]
  • Yan-Qing Li, Pan-Na Huang, Hao-Zhe Zhang, Lu-Yu Han, Ruo-Xiang Miao, Wan-Yun Feng, Hua Pan, Lin Feng, Xin-Hua Wu, Juan He, Xu Teng, Xiao-Ning Wang. [Chronic psychological stress exacerbates aortic medial calcification via glucocorticoids]. Sheng li xue bao : [Acta physiologica Sinica]. 2022 Dec; 74(6):927-938. doi: . [PMID: 36594381]
  • Shahil H Patel, Alba Timón-Gómez, Hari Pradhyumnan, Berk Mankaliye, Kunjan R Dave, Miguel A Perez-Pinzon, Ami P Raval. The Impact of Nicotine along with Oral Contraceptive Exposure on Brain Fatty Acid Metabolism in Female Rats. International journal of molecular sciences. 2022 Dec; 23(24):. doi: 10.3390/ijms232416075. [PMID: 36555717]
  • Kaifeng Zheng, Zitao Wang, Lu Pang, Zhongbang Song, Heping Zhao, Yingdian Wang, Bingwu Wang, Shengcheng Han. Systematic Identification of Methyl Jasmonate-Responsive Long Noncoding RNAs and Their Nearby Coding Genes Unveils Their Potential Defence Roles in Tobacco BY-2 Cells. International journal of molecular sciences. 2022 Dec; 23(24):. doi: 10.3390/ijms232415568. [PMID: 36555209]
  • Ahmed E Amer, George S G Shehatou, Hassan A El-Kashef, Manar A Nader, Ahmed R El-Sheakh. Flavocoxid Ameliorates Aortic Calcification Induced by Hypervitaminosis D3 and Nicotine in Rats Via Targeting TNF-α, IL-1β, iNOS, and Osteogenic Runx2. Cardiovascular drugs and therapy. 2022 Dec; 36(6):1047-1059. doi: 10.1007/s10557-021-07227-6. [PMID: 34309798]
  • Nina Djapic. Supercritical Carbon Dioxide Extraction of Nicotiana tabacum Leaves: Optimization of Extraction Yield and Nicotine Content. Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238328. [PMID: 36500420]
  • Csaba Laszlo, Kacper Kaminski, Haifeng Guan, Maria Fatarova, Jianbing Wei, Alexandre Bergounioux, Walter K Schlage, Sandra Schorderet-Weber, Philippe A Guy, Nikolai V Ivanov, Kai Lamottke, Julia Hoeng. Fractionation and Extraction Optimization of Potentially Valuable Compounds and Their Profiling in Six Varieties of Two Nicotiana Species. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27228105. [PMID: 36432206]
  • Thomas Meikopoulos, Olga Begou, Theodoros Panagoulis, Eleni Kontogiannidou, Dimitrios G Fatouros, John H Miller, Georgios Theodoridis, Helen Gika. UHPLC-MS/MS method for the simultaneous determination of nicotine and tobacco-specific nitrosamines NNN and NNK for use in preclinical studies. Analytical and bioanalytical chemistry. 2022 Nov; 414(27):7865-7875. doi: 10.1007/s00216-022-04319-6. [PMID: 36163593]
  • Sungshim L Park, Loic Le Marchand, Guang Cheng, Silvia Balbo, Menglan Chen, Steven G Carmella, Nicole M Thomson, Younghan Lee, Yesha M Patel, Daniel O Stram, Joni Jensen, Dorothy K Hatsukami, Sharon E Murphy, Stephen S Hecht. Quantitation of DNA Adducts Resulting from Acrolein Exposure and Lipid Peroxidation in Oral Cells of Cigarette Smokers from Three Racial/Ethnic Groups with Differing Risks for Lung Cancer. Chemical research in toxicology. 2022 10; 35(10):1914-1922. doi: 10.1021/acs.chemrestox.2c00171. [PMID: 35998368]
  • Zhi-Min Wang, Sha Li, Cheng-Cheng Shi, Lin-Jie Xie, Kai-Yun Fu, Wei-Hua Jiang. The actions of neonicotinoid insecticides on nicotinic acetylcholine subunits Ldα1 and Ldα8 of Leptinotarsa decemlineata and assembled receptors. Insect science. 2022 Oct; 29(5):1387-1400. doi: 10.1111/1744-7917.13005. [PMID: 35038787]
  • Mizanur Rahman, Martin Irmler, Micol Introna, Johannes Beckers, Lena Palmberg, Gunnar Johanson, Swapna Upadhyay, Koustav Ganguly. Insight into the pulmonary molecular toxicity of heated tobacco products using human bronchial and alveolar mucosa models at air-liquid interface. Scientific reports. 2022 09; 12(1):16396. doi: 10.1038/s41598-022-20657-y. [PMID: 36180488]
  • Wael Ammar Aldaddou, Abdullah S M Aljohani, Idris Adewale Ahmed, Naser A Al-Wabel, Ibrahim M El-Ashmawy. Ameliorative effect of methanolic extract of Tribulus terrestris L. on nicotine and lead-induced degeneration of sperm quality in male rats. Journal of ethnopharmacology. 2022 Sep; 295(?):115337. doi: 10.1016/j.jep.2022.115337. [PMID: 35605919]
  • William A Smith, Yuki Matsuba, Ralph E Dewey. Knockout of a key gene of the nicotine biosynthetic pathway severely affects tobacco growth under field, but not greenhouse conditions. BMC research notes. 2022 Sep; 15(1):291. doi: 10.1186/s13104-022-06188-9. [PMID: 36068583]
  • Xinyu Zhao, Shugang Guo, Rui Zhang, Lu Liu, Lan Guo, Gaisheng Liu, Liuquan Jiang, Qiang Li, Baolong Pan, Jisheng Nie, Jin Yang. The interaction effects of secondhand smoke exposure and overweight on the prevalence of hypertension in Chinese coke oven workers and NHANES participants (2013-2016). Chemosphere. 2022 Sep; 303(Pt 2):135120. doi: 10.1016/j.chemosphere.2022.135120. [PMID: 35644234]
  • Madiha Sarwar, Sadia Ahsin, Gule Naghma Saeed, Hira Ashraf. Role of r-irisin in Nicotine-induced Oxidative Stress and Endothelial Dysfunction in BALB/c mice. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2022 Sep; 32(9):1175-1180. doi: 10.29271/jcpsp.2022.09.1175. [PMID: 36089716]
  • Victoria Paulus, Joël Billieux, Amine Benyamina, Laurent Karila. Cannabidiol in the context of substance use disorder treatment: A systematic review. Addictive behaviors. 2022 09; 132(?):107360. doi: 10.1016/j.addbeh.2022.107360. [PMID: 35580370]
  • Tsubasa Shoji, Koki Moriyama, Nicolas Sierro, Sonia Ouadi, Nikolai V Ivanov, Takashi Hashimoto, Kazuki Saito. Natural and induced variations in transcriptional regulator genes result in low-nicotine phenotypes in tobacco. The Plant journal : for cell and molecular biology. 2022 09; 111(6):1768-1779. doi: 10.1111/tpj.15923. [PMID: 35883194]
  • Roberta Zilles Hahn, Marcos Frank Bastiani, Lilian de Lima Feltraco Lizot, Anelise Schneider, Isabela Caroline da Silva Moreira, Yasmin Fazenda Meireles, Mariana Freitas Viana, Carlos Augusto do Nascimento, Rafael Linden. Long-term monitoring of drug consumption patterns during the COVID-19 pandemic in a small-sized community in Brazil through wastewater-based epidemiology. Chemosphere. 2022 Sep; 302(?):134907. doi: 10.1016/j.chemosphere.2022.134907. [PMID: 35561781]
  • Amany Abdel-Rahman Mohamed, Sanad S El-Kholy, Naief Dahran, Khlood M El Bohy, Gihan G Moustafa, Taghred M Saber, Mohamed M M Metwally, Rasha A Gaber, Leena S Alqahtani, Gomaa Mostafa-Hedeab, Eman S El-Shetry. Scrutinizing pathways of nicotine effect on renal Alpha-7 nicotinic acetylcholine receptor and Mitogen-activated protein kinase (MAPK) expression in Ehrlich ascites carcinoma-bearing mice: Role of Chlorella vulgaris. Gene. 2022 Aug; 837(?):146697. doi: 10.1016/j.gene.2022.146697. [PMID: 35764235]
  • Wei Li, Mayra Vargas-Rivera, Thomas E Eissenberg, Alan Shihadeh, Soha Talih, Wasim Maziak. Effect of menthol/mint-flavored pods on young JUUL E-cigarette users' subjective experience, puffing behavior, and nicotine exposure: A pilot study. Drug and alcohol dependence. 2022 Aug; 237(?):109516. doi: 10.1016/j.drugalcdep.2022.109516. [PMID: 35679691]
  • Ali Zein Alabiden Tlais, Andrea Polo, Pasquale Filannino, Vincenzo Cantatore, Marco Gobbetti, Raffaella Di Cagno. Biofilm formation as an extra gear for Apilactobacillus kunkeei to counter the threat of agrochemicals in honeybee crop. Microbial biotechnology. 2022 08; 15(8):2160-2175. doi: 10.1111/1751-7915.14051. [PMID: 35417624]
  • Katherine D Wick, Xiaohui Fang, Mazharul Maishan, Shotaro Matsumoto, Natasha Spottiswoode, Aartik Sarma, Camille Simoneau, Manisha Khakoo, Chaz Langelier, Carolyn S Calfee, Jeffrey E Gotts, Michael A Matthay. Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells. American journal of physiology. Lung cellular and molecular physiology. 2022 08; 323(2):L152-L164. doi: 10.1152/ajplung.00503.2021. [PMID: 35670478]
  • William E Pelham, Dilara Yuksel, Susan F Tapert, Fiona C Baker, Kilian M Pohl, Wesley K Thompson, Simon Podhajsky, Chase Reuter, Qingyu Zhao, Sonja C Eberson-Shumate, Duncan B Clark, David B Goldston, Kate B Nooner, Sandra A Brown. Did the acute impact of the COVID-19 pandemic on drinking or nicotine use persist? Evidence from a cohort of emerging adults followed for up to nine years. Addictive behaviors. 2022 08; 131(?):107313. doi: 10.1016/j.addbeh.2022.107313. [PMID: 35413486]
  • Yulin Sun, Hongjuan Wang, Huan Chen, Sen Zhang, Jun Li, Jingni Zhang, Jianlu Tian, Youyu Zhang, Hongwei Hou, Qingyuan Hu. Nicotine Inhibits the Cytotoxicity and Genotoxicity of NNK Mediated by CYP2A13 in BEAS-2B Cells. Molecules (Basel, Switzerland). 2022 Jul; 27(15):. doi: 10.3390/molecules27154851. [PMID: 35956805]
  • Sridhar Chinthakindi, Kurunthachalam Kannan. Variability in urinary concentrations of primary aromatic amines. The Science of the total environment. 2022 Jul; 831(?):154768. doi: 10.1016/j.scitotenv.2022.154768. [PMID: 35341833]
  • Naser A Alsharairi. Insights into the Mechanisms of Action of Proanthocyanidins and Anthocyanins in the Treatment of Nicotine-Induced Non-Small Cell Lung Cancer. International journal of molecular sciences. 2022 Jul; 23(14):. doi: 10.3390/ijms23147905. [PMID: 35887251]
  • Karen Muyor, Jonas Laget, Irene Cortijo, Flore Duranton, Bernard Jover, Àngel Argilés, Nathalie Gayrard. Vascular calcification in different arterial beds in ex vivo ring culture and in vivo rat model. Scientific reports. 2022 Jul; 12(1):11861. doi: 10.1038/s41598-022-15739-w. [PMID: 35831341]
  • Sarah Yahia, Ahmed S Abo Dena, Rasha M El Nashar, Ibrahim M El-Sherbiny. Nanomicelles-in-coaxial nanofibers with exit channels as a transdermal delivery platform for smoking cessation. Journal of materials chemistry. B. 2022 Jul; 10(26):4984-4998. doi: 10.1039/d2tb00818a. [PMID: 35708499]
  • Guylaine Labro, Florence Tubach, Lisa Belin, Jean-Louis Dubost, David Osman, Grégoire Muller, Jean-Pierre Quenot, Daniel Da Silva, Jonathan Zarka, Matthieu Turpin, Julien Mayaux, Christian Lamer, Denis Doyen, Guillaume Chevrel, Gaétan Plantefeve, Sophie Demeret, Gaël Piton, Cyril Manzon, Evelina Ochin, Raphael Gaillard, Bertrand Dautzenberg, Mathieu Baldacini, Said Lebbah, Makoto Miyara, Marc Pineton de Chambrun, Zahir Amoura, Alain Combes. Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trial. Intensive care medicine. 2022 Jul; 48(7):876-887. doi: 10.1007/s00134-022-06721-1. [PMID: 35676335]
  • Brittney Keller-Hamilton, Toral Mehta, Jessica J Hale, Eleanor L S Leavens, Alan Shihadeh, Thomas Eissenberg, Marielle C Brinkman, Theodore L Wagener. Effects of flavourants and humectants on waterpipe tobacco puffing behaviour, biomarkers of exposure and subjective effects among adults with high versus low nicotine dependence. Tobacco control. 2022 Jul; 31(4):527-533. doi: 10.1136/tobaccocontrol-2020-056062. [PMID: 33408120]
  • Dong Zhang, Jingbo Dai, Yong Cao, Zhaoxia Wang, Zhiguang Qiao, Zhongdong Qiao. Nicotine exposure of male mice protects offspring against carbon tetrachloride-induced acute liver injury. Journal of biochemical and molecular toxicology. 2022 Jul; 36(7):e23069. doi: 10.1002/jbt.23069. [PMID: 35411647]
  • Fawaz Alasmari, Abdullah F Alasmari, Ehab Elzayat, Majed M Alotaibi, Farraj M Alotaibi, Mohamed W Attwa, Fars K Alanazi, Elkhatim H Abdelgadir, Syed Rizwan Ahmad, Faleh Alqahtani, Salim S Al-Rejaie, Musaad A Alshammari. Nicotine and cotinine quantification after a 4-week inhalation of electronic cigarette vapors in male and female mice using UPLC-MS/MS. Saudi medical journal. 2022 Jul; 43(7):678-686. doi: 10.15537/smj.2022.43.7.20220142. [PMID: 35830983]
  • Soheil Bagheri, Ahmad Reza Saghazade, Samira Abbaszadeh-Mashkani, Hamid Reza Banafshe, Fatemeh Sadat Ghoreishi, Azam Mesdaghinia, Amir Ghaderi. The effect of vitamin D supplementation on tobacco-related disorders in individuals with a tobacco use disorder: a randomized clinical trial. Journal of addictive diseases. 2022 Jul; 40(3):382-393. doi: 10.1080/10550887.2021.2010971. [PMID: 34962457]
  • Joanna Kasprzyk, Wojciech Piekoszewski, Artur Tezyk, Maksymilian Kulza, Ewa Florek. Effects of excessive alcohol drinking on nicotine biotransformation in rats. Scientific reports. 2022 06; 12(1):11066. doi: 10.1038/s41598-022-15199-2. [PMID: 35773467]
  • Anna K Whitehead, Nicholas D Fried, Zhen Li, Kandasamy Neelamegam, Charlotte S Pearson, Kyle B LaPenna, Thomas E Sharp, David J Lefer, Eric Lazartigues, Jason D Gardner, Xinping Yue. Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction. Clinical science (London, England : 1979). 2022 06; 136(12):973-987. doi: 10.1042/cs20220083. [PMID: 35678315]
  • Yasir Abbasi, Marie-Claire Van Hout, Mohamed Faragalla, Lynn Itani. Knowledge and Use of Electronic Cigarettes in Young Adults in the United Arab Emirates, Particularly during the COVID-19 Pandemic. International journal of environmental research and public health. 2022 Jun; 19(13):. doi: 10.3390/ijerph19137828. [PMID: 35805487]
  • Kashala Fabrice Kapiamba, Weixing Hao, Stephen Adom, Wenyan Liu, Yue-Wern Huang, Yang Wang. Examining Metal Contents in Primary and Secondhand Aerosols Released by Electronic Cigarettes. Chemical research in toxicology. 2022 Jun; 35(6):954-962. doi: 10.1021/acs.chemrestox.1c00411. [PMID: 35385266]
  • Jeffery S Edmiston, Katy M Webb, Jingzhu Wang, Douglas Oliveri, Qiwei Liang, Mohamadi Sarkar. Biomarkers of Exposure and Biomarkers of Potential Harm in Adult Smokers Who Switch to e-Vapor Products Relative to Cigarette Smoking in a 24-week, Randomized, Clinical Trial. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2022 06; 24(7):1047-1054. doi: 10.1093/ntr/ntac029. [PMID: 35134961]
  • Poonam Rao, Daniel D Han, Kelly Tan, Leila Mohammadi, Ronak Derakhshandeh, Mina Navabzadeh, Natasha Goyal, Matthew L Springer. Comparable Impairment of Vascular Endothelial Function by a Wide Range of Electronic Nicotine Delivery Devices. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2022 06; 24(7):1055-1062. doi: 10.1093/ntr/ntac019. [PMID: 35100430]
  • Guang Cheng, Jiehong Guo, Steven G Carmella, Bruce Lindgren, Joshua Ikuemonisan, Brittany Niesen, Joni Jensen, Dorothy K Hatsukami, Silvia Balbo, Stephen S Hecht. Increased acrolein-DNA adducts in buccal brushings of e-cigarette users. Carcinogenesis. 2022 06; 43(5):437-444. doi: 10.1093/carcin/bgac026. [PMID: 35239969]
  • Ian M Fearon, Karin Gilligan, Ryan G N Seltzer, Willie McKinney. A randomised, crossover, clinical study to assess nicotine pharmacokinetics and subjective effects of the BIDI® stick ENDS compared with combustible cigarettes and a comparator ENDS in adult smokers. Harm reduction journal. 2022 06; 19(1):57. doi: 10.1186/s12954-022-00638-0. [PMID: 35655314]
  • Michael J Parks, Nancy L Fleischer, Megan E Patrick. Increased nicotine vaping due to the COVID-19 pandemic among US young adults: Associations with nicotine dependence, vaping frequency, and reasons for use. Preventive medicine. 2022 06; 159(?):107059. doi: 10.1016/j.ypmed.2022.107059. [PMID: 35460719]
  • Kelly C Young-Wolff, Varada Sarovar, Lue-Yen Tucker, Deborah Ansley, Nancy Goler, Amy Conway, Allison Ettenger, Tara R Foti, Qiana L Brown, Ellen T Kurtzman, Sara R Adams, Stacey E Alexeeff. Trends in Cannabis Polysubstance Use During Early Pregnancy Among Patients in a Large Health Care System in Northern California. JAMA network open. 2022 06; 5(6):e2215418. doi: 10.1001/jamanetworkopen.2022.15418. [PMID: 35666502]
  • Victor Guérif, Michael Atlan, Sarra Cristofari. Pathophysiology of nicotine, place of nicotine substitutes and electronic cigarettes in plastic surgery: A review of the literature. Annales de chirurgie plastique et esthetique. 2022 Jun; 67(3):119-124. doi: 10.1016/j.anplas.2022.05.001. [PMID: 35672174]
  • Wang Peng, Li Changlu, Seshadri Sriram, Jiangang Liu. Understanding the Interaction Between Prostaglandins and Toll-Like Receptors in Nicotine-Induced Rectal Tumor in Animals. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 2022 06; 33(6):491-496. doi: 10.5152/tjg.2020.19755. [PMID: 35786617]
  • Erin A Vogel, Neal L Benowitz, Jordan Skan, Matthew Schnellbaecher, Judith J Prochaska. Correlates of the nicotine metabolite ratio in Alaska Native people who smoke cigarettes. Experimental and clinical psychopharmacology. 2022 Jun; 30(3):359-364. doi: 10.1037/pha0000461. [PMID: 33856821]
  • Nathan A Silver, Elexis C Kierstead, Jodie Briggs, Barbara Schillo. Charming e-cigarette users with distorted science: a survey examining social media platform use, nicotine-related misinformation and attitudes towards the tobacco industry. BMJ open. 2022 06; 12(6):e057027. doi: 10.1136/bmjopen-2021-057027. [PMID: 35649587]
  • Haley A Mulder, Adam C Pearcy, Matthew S Halquist. Characterization of molecularly imprinted polymers for the extraction of tobacco alkaloids and their metabolites in human urine. Biomedical chromatography : BMC. 2022 Jun; 36(6):e5361. doi: 10.1002/bmc.5361. [PMID: 35261061]
  • Saisree S, Arya Nair J S, Sandhya K Y. A highly stable copper nano cluster on nitrogen-doped graphene quantum dots for the simultaneous electrochemical sensing of dopamine, serotonin, and nicotine: a possible addiction scrutinizing strategy. Journal of materials chemistry. B. 2022 06; 10(21):3974-3988. doi: 10.1039/d1tb02368c. [PMID: 35319044]