Icariin (BioDeep_00000000097)

   

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

化学式: C33H40O15 (676.2367)
中文名称: 淫羊藿苷, 淫羊藿甙
谱图信息: 最多检出来源 Viridiplantae(plant) 43.72%

分子结构信息

SMILES: C(C5O)(OC(C(O)C5O)CO)Oc(c(CC=C(C)C)1)cc(O)c(C3=O)c1OC(=C3OC(O4)C(O)C(O)C(C(C)4)O)c(c2)ccc(c2)OC
InChI: InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3

描述信息

Icariin is a member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4, and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo). It has a role as a bone density conservation agent, a phytoestrogen, an EC 3.1.4.35 (3,5-cyclic-GMP phosphodiesterase) inhibitor and an antioxidant. It is a glycosyloxyflavone and a member of flavonols.
Icariin has been investigated for the basic science of the Pharmacokinetic Profile of Icariin in Humans.
Icariin is a natural product found in Epimedium pubescens, Epimedium grandiflorum, and other organisms with data available.
Origin: Plant, Pyrans
Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.077
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.073
Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.
Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.
Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.

同义名列表

43 个代谢物同义名

5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-3-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one; 5-Hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,4S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-4H-chromen-4-one; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one; 5-HYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUT-2-EN-1-YL)-7-{[3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL]OXY}-3-[(3,4,5-TRIHYDROXY-6-METHYLOXAN-2-YL)OXY]-4H-CHROMEN-4-ONE; 4H-1-BENZOPYRAN-4-ONE, 3-((6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)OXY)-7-(.BETA.-D-GLUCOPYRANOSYLOXY)-5-HYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYL-2-BUTEN-1-YL)-; 3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-; 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside; 3-((6-deoxymannopyranosyl)oxy)-7-(glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one; Icariin, analytical standard; EPIMEDII HERBA ICARIIN [MI]; TZJALUIVHRYQQB-XLRXWWTNSA-N; Icariin, >=94\\% (HPLC); Epimedii herba icariin; Spectrum4_001975; Spectrum3_001130; Spectrum5_000933; -Anhydroicaritin; Spectrum2_001695; UNII-VNM47R2QSQ; KBio3_002099; VNM47R2QSQ; Ieariline; Icariine; Icariin; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-3-[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-tetrahydropyranyl]oxy]-4-chromenone; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-chromen-4-one; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-chromone; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chromen-4-one; SDCCGMLS-0066754.P001; SPECTRUM1505257; BSPBio_002599; KBioGR_002475; SPBio_001650; ZINC03960893; MLS000759413; SMR000466309; BB_NC-0999; 489-32-7; 3- (6-Deoxy-alpha-L-mannopyranosyloxy) -7- (beta-D-glucopyranosyloxy) -5-hydroxy-2- (4-methoxyphenyl) -8- (3-methyl-2-butenyl) -4H-1-benzopyran-4-one; Icariin



数据库引用编号

78 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

79 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ABCB1, ANG, BGLAP, CCND1, CTNNB1, EGFR, ESR1, PIK3C3, PTGS2, RELA, RUNX2, SIRT1, SMAD2, VEGFA
Peripheral membrane protein 2 ESR1, PTGS2
Endosome membrane 2 BACE1, EGFR
Endoplasmic reticulum membrane 2 EGFR, PTGS2
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 12 ANG, CCND1, CTNNB1, EGFR, ESR1, JUN, PPARA, RELA, RUNX2, SIRT1, SMAD2, VEGFA
autophagosome 1 PIK3C3
cytosol 10 ANG, CCND1, CTNNB1, ESR1, PDE5A, PIK3C3, RELA, RUNX2, SIRT1, SMAD2
dendrite 2 BACE1, BGLAP
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
trans-Golgi network 1 BACE1
centrosome 2 CCND1, CTNNB1
nucleoplasm 9 CCND1, CTNNB1, ESR1, JUN, PPARA, RELA, RUNX2, SIRT1, SMAD2
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 5 ABCB1, BACE1, CTNNB1, EGFR, ESR1
Cytoplasmic side 1 ESR1
lamellipodium 1 CTNNB1
ruffle membrane 1 EGFR
Cell projection, axon 1 BACE1
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCB1
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 2 CTNNB1, EGFR
cell surface 4 ABCB1, BACE1, EGFR, VEGFA
glutamatergic synapse 4 CTNNB1, EGFR, PIK3C3, RELA
Golgi apparatus 3 BACE1, ESR1, VEGFA
Golgi membrane 1 EGFR
growth cone 1 ANG
neuronal cell body 2 ANG, BACE1
presynaptic membrane 1 CTNNB1
synaptic vesicle 1 BACE1
Lysosome 1 BACE1
endosome 3 BACE1, EGFR, PIK3C3
plasma membrane 6 ABCB1, BACE1, CTNNB1, EGFR, ESR1, TNFRSF11B
Membrane 8 ABCB1, BACE1, CTNNB1, EGFR, ESR1, PIK3C3, SMAD2, VEGFA
apical plasma membrane 2 ABCB1, EGFR
axon 1 BACE1
basolateral plasma membrane 2 CTNNB1, EGFR
caveola 1 PTGS2
extracellular exosome 2 ABCB1, CTNNB1
endoplasmic reticulum 3 BACE1, PTGS2, VEGFA
extracellular space 6 ANG, BGLAP, EGFR, IL4, TNFRSF11B, VEGFA
perinuclear region of cytoplasm 2 CTNNB1, EGFR
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CTNNB1, VEGFA
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
mitochondrion 1 SIRT1
protein-containing complex 5 CTNNB1, EGFR, ESR1, PTGS2, SMAD2
Microsome membrane 1 PTGS2
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 2 BACE1, EGFR
Secreted 5 ANG, BGLAP, IL4, TNFRSF11B, VEGFA
extracellular region 5 ANG, BGLAP, IL4, TNFRSF11B, VEGFA
hippocampal mossy fiber to CA3 synapse 1 BACE1
transcription regulator complex 6 CTNNB1, ESR1, JUN, RELA, RUNX2, SMAD2
Nucleus membrane 1 CCND1
nuclear membrane 2 CCND1, EGFR
Secreted, extracellular space, extracellular matrix 1 VEGFA
multivesicular body 1 BACE1
actin cytoskeleton 1 ANG
perikaryon 1 BGLAP
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 2 ANG, SIRT1
Wnt signalosome 1 CTNNB1
midbody 1 PIK3C3
Early endosome 1 BACE1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
recycling endosome 1 BACE1
vesicle 1 BGLAP
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 ABCB1
heterochromatin 1 SIRT1
Membrane raft 2 BACE1, EGFR
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CTNNB1, EGFR
GABA-ergic synapse 1 PIK3C3
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 2 TNFRSF11B, VEGFA
Peroxisome 1 PIK3C3
basement membrane 1 ANG
intracellular vesicle 1 EGFR
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
secretory granule 1 VEGFA
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
axoneme 1 PIK3C3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
Late endosome 2 BACE1, PIK3C3
receptor complex 2 EGFR, TNFRSF11B
neuron projection 1 PTGS2
chromatin 7 ESR1, JUN, PPARA, RELA, RUNX2, SIRT1, SMAD2
phagocytic vesicle membrane 1 PIK3C3
cell periphery 1 CTNNB1
Chromosome 1 ANG
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Golgi apparatus, trans-Golgi network 1 BACE1
Nucleus, nucleolus 1 ANG
spindle pole 1 CTNNB1
nuclear chromosome 1 JUN
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
Endomembrane system 2 BACE1, CTNNB1
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Cytoplasmic vesicle membrane 1 BACE1
Cell projection, dendrite 1 BACE1
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
euchromatin 4 CTNNB1, ESR1, JUN, SIRT1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 3 BACE1, BGLAP, PTGS2
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
beta-catenin-TCF complex 1 CTNNB1
presynaptic endosome 1 PIK3C3
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 ESR1
heteromeric SMAD protein complex 1 SMAD2
SMAD protein complex 1 SMAD2
protein-DNA complex 1 CTNNB1
external side of apical plasma membrane 1 ABCB1
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
catenin complex 1 CTNNB1
activin responsive factor complex 1 SMAD2
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
postsynaptic endosome 1 PIK3C3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transcription factor AP-1 complex 1 JUN
Autolysosome 1 PIK3C3
angiogenin-PRI complex 1 ANG
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
Golgi-associated vesicle lumen 1 BACE1
homomeric SMAD protein complex 1 SMAD2
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Tieshu Li, Shuling Li, Yin Xiong, Xinxin Li, Chun Ma, Zhiying Guan, Lihua Yang. Binary Nano-inhalant Formulation of Icariin Enhances Cognitive Function in Vascular Dementia via BDNF/TrkB Signaling and Anti-inflammatory Effects. Neurochemical research. 2024 Jul; 49(7):1720-1734. doi: 10.1007/s11064-024-04129-5. [PMID: 38520637]
  • Juan Xiao, Chenggen Luo, Anmao Li, Fanglan Cai, Yu Wang, Xiaoli Pan, Liu Xu, Zihong Wang, Zhouxiong Xing, Limei Yu, Yong Chen, Mei Tian. Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling. International immunopharmacology. 2024 May; 133(?):112010. doi: 10.1016/j.intimp.2024.112010. [PMID: 38636375]
  • Wenwen Ding, Linhui Shangguan, Hongquan Li, Yinghui Bao, Fida Noor, Abdul Haseeb, Panpan Sun, Hua Zhang, Wei Yin, Kuohai Fan, Huizhen Yang, Zhenbiao Zhang, Na Sun. Dietary supplementation of osthole and icariin improves the production performance of laying hens by promoting follicular development. Poultry science. 2024 May; 103(5):103579. doi: 10.1016/j.psj.2024.103579. [PMID: 38430778]
  • Tian-Ci Zhang, Yi-Can Lin, Ning-Ning Sun, Shan Liu, Wen-Zhu Hu, Yan Zhao, Xian-Hui Dong, Xiao-Ping He. Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation. Neurochemistry international. 2024 May; 175(?):105705. doi: 10.1016/j.neuint.2024.105705. [PMID: 38412923]
  • Xiaokun Liu, Xiaoqian Chu, Lingling Li, Shanshan Man, Li Wang, Yuhong Bian, Huifang Zhou. Differential expression of circular RNAs in human umbilical cord mesenchymal stem cells treated with icariin. Medicine. 2024 Mar; 103(12):e37549. doi: 10.1097/md.0000000000037549. [PMID: 38517991]
  • Chunyan Fang, Yaodong You, Fan Luo, Zheng Li, Yifeng Shen, Fangyue Wang, Jingyi Zhang, Ren-You Gan, Yulong Ye. Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A-Induced Spermatogenesis Dysfunction. Advanced healthcare materials. 2024 Mar; 13(6):e2302899. doi: 10.1002/adhm.202302899. [PMID: 37940136]
  • Li Li, Pu-Hua Zeng, Ren-Yi Yang, Ying Deng, Zuo-Mei He, Xin Xia, Ding-Yao Zhu, Qing-Hua Peng. [Study on mechanism of icariin-induced ferroptosis in HepG2 hepatoma carcinoma cells through PPARG/FABP4/GPX4 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Mar; 49(5):1295-1309. doi: 10.19540/j.cnki.cjcmm.20231212.703. [PMID: 38621977]
  • Wenhui Yao, Rongpin Tao, Yue Xu, Zhe-Sheng Chen, Xuansheng Ding, Lisheng Wan. AR/RKIP pathway mediates the inhibitory effects of icariin on renal fibrosis and endothelial-to-mesenchymal transition in type 2 diabetic nephropathy. Journal of ethnopharmacology. 2024 Feb; 320(?):117414. doi: 10.1016/j.jep.2023.117414. [PMID: 37977422]
  • Wei Liu, Shouyu Xiang, Yingcong Wu, Dinghao Zhang, Chuhai Xie, Hailan Hu, Qi Liu. Icariin promotes bone marrow mesenchymal stem cells osteogenic differentiation via the mTOR/autophagy pathway to improve ketogenic diet-associated osteoporosis. Journal of orthopaedic surgery and research. 2024 Feb; 19(1):127. doi: 10.1186/s13018-024-04529-x. [PMID: 38326818]
  • Denglu Zhang, Shuai Liu, Huihui Jiang, Shuangde Liu, Feng Kong. DIA proteomics analysis reveals the mechanism of folic acid-induced acute kidney injury and the effects of icariin. Chemico-biological interactions. 2024 Jan; 390(?):110878. doi: 10.1016/j.cbi.2024.110878. [PMID: 38272249]
  • Bo Song, Fuxia Wei, Jiehao Peng, Xiuhong Wei, Mingran Liu, Zhongbiao Nie, Yanmiao Ma, Tao Peng. Icariin regulates EMT and stem cell-like character in breast cancer through modulating lncRNA NEAT1/TGFβ/SMAD2 signaling pathway. Biological & pharmaceutical bulletin. 2024 Jan; ?(?):. doi: 10.1248/bpb.b23-00668. [PMID: 38220208]
  • Li-Juan Song, Qing-Xian Han, Zhi-Bin Ding, Kexin Liu, Xiao-Xu Zhang, Min-Fang Guo, Dong Ma, Qing Wang, Bao-Guo Xiao, Cun-Gen Ma. Icariin ameliorates the cuprizone-induced demyelination associated with antioxidation and anti-inflammation. Inflammopharmacology. 2024 Jan; ?(?):. doi: 10.1007/s10787-023-01388-6. [PMID: 38177566]
  • Hend A Sabry, Mai M Zahra. Icariin attenuates dopaminergic neural loss in haloperidol-induced Parkinsonism in rats via GSK-3β and tyrosine hydroxylase regulation mechanism. Journal of chemical neuroanatomy. 2023 Dec; 136(?):102385. doi: 10.1016/j.jchemneu.2023.102385. [PMID: 38160784]
  • Monika N Todorova, Martina S Savova, Liliya V Mihaylova, Milen I Georgiev. Icariin Improves Stress Resistance and Extends Lifespan in Caenorhabditis elegans through hsf-1 and daf-2-Driven Hormesis. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010352. [PMID: 38203522]
  • Ting An, Guangyuan Lin, Yang Liu, Lei Qin, Yuquan Xu, Xudong Feng, Chun Li. De novo biosynthesis of anticarcinogenic icariin in engineered yeast. Metabolic engineering. 2023 Nov; 80(?):207-215. doi: 10.1016/j.ymben.2023.10.003. [PMID: 37852432]
  • Meifang Wu, Naying Zheng, Xiaoxiao Zhan, Jianzhang He, Min Xiao, Zhenghong Zuo, Chengyong He. Icariin induces developmental toxicity via thyroid hormone disruption in zebrafish larvae. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Oct; 182(?):114155. doi: 10.1016/j.fct.2023.114155. [PMID: 37898232]
  • Hang Zhao, Hongyang Tian. Icariin alleviates high-fat diet-induced nonalcoholic fatty liver disease via up-regulating miR-206 to mediate NF-κB and MAPK pathways. Journal of biochemical and molecular toxicology. 2023 Oct; ?(?):e23566. doi: 10.1002/jbt.23566. [PMID: 37888945]
  • Chiwei Chen, Shengqi Wang, Neng Wang, Yifeng Zheng, Jianfu Zhou, Min Hong, Zhiqiang Chen, Shusheng Wang, Zhiyu Wang, Songtao Xiang. Icariin inhibits prostate cancer bone metastasis and destruction via suppressing TAM/CCL5-mediated osteoclastogenesis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 120(?):155076. doi: 10.1016/j.phymed.2023.155076. [PMID: 37716031]
  • Zhiming Wu, Qin Liu, Zhengliu Cao, Hui Li, Yifen Zhou, Peng Zhang. Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway. Immunopharmacology and immunotoxicology. 2023 Sep; ?(?):1-7. doi: 10.1080/08923973.2023.2253990. [PMID: 37647355]
  • Yurong Ma, Chong Zhao, Hongbo Hu, Shutao Yin. Liver protecting effects and molecular mechanisms of icariin and its metabolites. Phytochemistry. 2023 Sep; 215(?):113841. doi: 10.1016/j.phytochem.2023.113841. [PMID: 37660725]
  • Yudan Zhao, Wanyue Yang, Xin Zhang, Chongning Lv, Jincai Lu. Icariin, the main prenylflavonoid of Epimedii Folium, ameliorated chronic kidney disease by modulating energy metabolism via AMPK activation. Journal of ethnopharmacology. 2023 Aug; 312(?):116543. doi: 10.1016/j.jep.2023.116543. [PMID: 37088241]
  • Sheng-Li Xia, Zi-Yuan Ma, Bin Wang, Feng Gao, Sheng-Yang Guo, Xu-Han Chen. Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1. Journal of orthopaedic surgery and research. 2023 Jul; 18(1):500. doi: 10.1186/s13018-023-03998-w. [PMID: 37454090]
  • Xindong Wang, Meng Zhang, Chenhan Mao, Chengbo Zhang, Wenqi Ma, Jiahui Tang, Dongyang Xiang, Xiaoxia Qi. Icariin alleviates ferroptosis-related atherosclerosis by promoting autophagy in xo-LDL-induced vascular endothelial cell injury and atherosclerotic mice. Phytotherapy research : PTR. 2023 Jun; ?(?):. doi: 10.1002/ptr.7854. [PMID: 37344941]
  • Ling Zuo, Yang Hai, Ruoyu Zhang, Biao Zuo, Jiayu Tian, Pan Li, Xiumei Ke, Meng Wang, Li Ren, Xuezhi Li, Xuekuan Huang, Jianwei Wang. Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome. European journal of pharmacology. 2023 Jun; ?(?):175825. doi: 10.1016/j.ejphar.2023.175825. [PMID: 37269973]
  • Lingyan Zheng, Sichen Wu, Haichao Jin, Jiaqi Wu, Xiaole Wang, Yuxiao Cao, Zhihao Zhou, Yaona Jiang, Linhong Li, Xinyue Yang, Qing Shen, Shunyuan Guo, Yuejian Shen, Changyu Li, Liting Ji. Molecular mechanisms and therapeutic potential of icariin in the treatment of Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 May; 116(?):154890. doi: 10.1016/j.phymed.2023.154890. [PMID: 37229892]
  • Peiyan Jiang, Lianyu Zhou, Zhulin Du, Linyang Zhao, Yexi Tang, Xinghang Fei, Lian Wang, Dabing Li, Song Li, Hui Yang, Xiaotang Fan, Huiling Liao. Icariin alleviates autistic-like behavior, hippocampal inflammation and vGlut1 expression in adult BTBR mice. Behavioural brain research. 2023 05; 445(?):114384. doi: 10.1016/j.bbr.2023.114384. [PMID: 36889463]
  • Yuqing Liu, Hongli Li, Xiaowei Wang, Jianhua Huang, Di Zhao, Yejun Tan, Zheyu Zhang, Zhen Zhang, Lemei Zhu, Beibei Wu, Zhibao Chen, Weijun Peng. Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology. Journal of translational medicine. 2023 Apr; 21(1):277. doi: 10.1186/s12967-023-04137-z. [PMID: 37095548]
  • Long Bai, Yanpeng Liu, Xiaohui Zhang, Peiru Chen, Ruiqiang Hang, Yin Xiao, Jing Wang, Changsheng Liu. Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy. Biomaterials. 2023 Apr; 297(?):122125. doi: 10.1016/j.biomaterials.2023.122125. [PMID: 37058900]
  • Fang Peng, Zhongyu Han, Haoran Chen, Qinxiu Zhang, Chi Liu, Xin Liang. The Effects of Treatment with Icariin on Immune Tolerance in the Recurrent Spontaneous Abortion Mice. Reproductive sciences (Thousand Oaks, Calif.). 2023 Mar; ?(?):. doi: 10.1007/s43032-023-01185-0. [PMID: 36890410]
  • Juntao Zhang, Fangyang Fan, Chao Zhang, Aifeng Liu, Man Shang, Lin Meng. Icariin-conditioned serum combined with chitosan attenuates cartilage injury in rabbit knees with osteochondral defect. Journal of orthopaedic surgery and research. 2023 Feb; 18(1):125. doi: 10.1186/s13018-023-03607-w. [PMID: 36805735]
  • Zunping Ke, Yuling Wang, Guzailinur Silimu, Zhangsheng Wang, Aimei Gao. Pharmacology-Based Prediction of the Targets and Mechanisms for Icariin against Myocardial Infarction. Medicina (Kaunas, Lithuania). 2023 Feb; 59(3):. doi: 10.3390/medicina59030420. [PMID: 36984421]
  • Juan Lv, Guozhong Xue, Yunxia Zhang, Xinbin Wang, Enlai Dai. Icariin synergizes therapeutic effect of dexamethasone on adriamycin-induced nephrotic syndrome. European journal of medical research. 2023 Jan; 28(1):52. doi: 10.1186/s40001-022-00973-9. [PMID: 36707848]
  • Qiuping Li, Hongying Zhang, Xinpeng Yan, Zhengxiao Zhao, Jian Qiu, Lingli Hu, Shan Jiang, Qing Kong, Jing Sun, Lulu Li. Up-regulation of PPAR-γ involved in the therapeutic effect of icariin on cigarette smoke-induced inflammation. Pulmonary pharmacology & therapeutics. 2023 Jan; 79(?):102197. doi: 10.1016/j.pupt.2023.102197. [PMID: 36690317]
  • Yang Hai, Ling Zuo, Meng Wang, Ruoyu Zhang, Munan Wang, Li Ren, Congwen Yang, Jianwei Wang. Icariin Alleviates Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome by Improving Liver Fatty Acid Oxidation and Inhibiting Lipid Accumulation. Molecules (Basel, Switzerland). 2023 Jan; 28(2):. doi: 10.3390/molecules28020517. [PMID: 36677577]
  • Peng Huang, Fengjun Wang, Yibing Zhang, Yang Zhang, Meng Qin, Jiahua Ji, Dexian Wei, Liqun Ren. Icariin alleviates atherosclerosis by regulating the miR-205-5p/ERBB4/AKT signaling pathway. International immunopharmacology. 2023 Jan; 114(?):109611. doi: 10.1016/j.intimp.2022.109611. [PMID: 36700779]
  • Pengzhen Wang, Pingping Zhu, Shaoheng Zhang, Wei Yuan, Zhihe Liu. Icariin activates far upstream element binding protein 1 to regulate hypoxia-inducible factor-1α and hypoxia-inducible factor-2α signaling and benefits chondrocytes. PeerJ. 2023; 11(?):e15917. doi: 10.7717/peerj.15917. [PMID: 37637163]
  • Wenjing Xu, Jin Ding, Bonan Li, Tiansong Sun, Xujun You, Qinghu He, Wen Sheng. Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer. BioFactors (Oxford, England). 2022 Dec; ?(?):. doi: 10.1002/biof.1927. [PMID: 36585763]
  • Peng Yu, Zhen Qian, Hongmei Yang, Tianyang Xu, Yulin Dai, Laihui Song, Jinling Liang, Yuying Shi, Zhiguo Zhang, Lijing Li. Icaritin, a metabolite of Icarrin, Alleviates non-alcoholic fatty liver disease via inhibition of lipogenesis and ER stress. European journal of pharmacology. 2022 Dec; 937(?):175378. doi: 10.1016/j.ejphar.2022.175378. [PMID: 36372277]
  • Jiao Wang, Liang Kong, Rui-Bo Guo, Si-Yu He, Xin-Ze Liu, Lu Zhang, Yang Liu, Yang Yu, Xue-Tao Li, Lan Cheng. Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer's disease. Drug delivery. 2022 Dec; 29(1):1648-1662. doi: 10.1080/10717544.2022.2072543. [PMID: 35616263]
  • Wen-Yao Yang, Hui-Juan Cao, Ling Li, Cui-Shan Huang, Ke-da Shi, Antonia Ru-Jia Sun, Ling Qin, Xin-Luan Wang. A Phytomolecule Icariin Protects from Sarcopenia Partially by Suppressing Myosin Heavy Chain Degradation in Orchiectomized Rats. Advanced biology. 2022 12; 6(12):e2200162. doi: 10.1002/adbi.202200162. [PMID: 36026561]
  • Bo Pan, Lianlian Xu, Jianjun Weng, Yuting Wang, Hongyan Ji, Bing Han, Xiaoli Zhu, Yanqing Liu. Effects of icariin on alleviating schizophrenia-like symptoms by regulating the miR-144-3p/ATP1B2/mTOR signalling pathway. Neuroscience letters. 2022 11; 791(?):136918. doi: 10.1016/j.neulet.2022.136918. [PMID: 36261079]
  • Li-Ming Yu, Xue Dong, Yin-Li Xu, Zi-Jun Zhou, Yu-Ting Huang, Ji-Kai Zhao, Deng-Yue Xu, Xiao-Dong Xue, Qiu-Sheng Zhao, Tao Liu, Zong-Tao Yin, Hui Jiang, Hui-Shan Wang. Icariin attenuates excessive alcohol consumption-induced susceptibility to atrial fibrillation through SIRT3 signaling. Biochimica et biophysica acta. Molecular basis of disease. 2022 10; 1868(10):166483. doi: 10.1016/j.bbadis.2022.166483. [PMID: 35798229]
  • Aanchal Verma, Kritika Aggarwal, Ritik Agrawal, Kajal Pradhan, Ahsas Goyal. Molecular mechanisms regulating the pharmacological actions of icariin with special focus on PI3K-AKT and Nrf-2 signaling pathways. Molecular biology reports. 2022 Sep; 49(9):9023-9032. doi: 10.1007/s11033-022-07778-3. [PMID: 35941411]
  • Zhi-Ming Wu, Yan-Ru Xiang, Xiao-Bo Zhu, Xiao-Dong Shi, Sha Chen, Xin Wan, Jian Guo. Icariin represses the inflammatory responses and survival of rheumatoid arthritis fibroblast-like synoviocytes by regulating the TRIB1/TLR2/NF-kB pathway. International immunopharmacology. 2022 Sep; 110(?):108991. doi: 10.1016/j.intimp.2022.108991. [PMID: 35792272]
  • Wenjing Du, Ting Zhang, Fangyong Yang, Aman Gul, Zhao Tang, Hu Zhang, Shan Jiang, Shiqiang Wang, Jingcheng Dong. Endocannabinoid signalling/cannabinoid receptor 2 is involved in icariin-mediated protective effects against bleomycin-induced pulmonary fibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Aug; 103(?):154187. doi: 10.1016/j.phymed.2022.154187. [PMID: 35667261]
  • Róbert Szabó, Csaba Pál Rácz, Francisc Vasile Dulf. Bioavailability Improvement Strategies for Icariin and Its Derivates: A Review. International journal of molecular sciences. 2022 Jul; 23(14):. doi: 10.3390/ijms23147519. [PMID: 35886867]
  • Zhangyang Bi, Wei Zhang, Xiaoyan Yan. Anti-inflammatory and immunoregulatory effects of icariin and icaritin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113180. doi: 10.1016/j.biopha.2022.113180. [PMID: 35676785]
  • Jie Zheng, Yuling Liao, Yuanyuan Xu, Zhentao Mo. Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats. Clinical and experimental pharmacology & physiology. 2022 07; 49(7):719-730. doi: 10.1111/1440-1681.13645. [PMID: 35451526]
  • Qiaoqi Zhang, Lei Xie, Lin Jiang, Jiaqing Ni, Wenke Han, Xiuhua Mi, Ping Wang. Icariin attenuates renal fibrosis in vivo and in vitro by inhibiting the Notch2/Hes-1 pathway. Growth factors (Chur, Switzerland). 2022 06; 40(1-2):26-36. doi: 10.1080/08977194.2022.2060094. [PMID: 35426327]
  • Haoran Chen, Linjiang Song, Xiaofang Xu, Zhongyu Han, Fang Peng, Qinxiu Zhang, Chi Liu, Xin Liang. The effect of icariin on autoimmune premature ovarian insufficiency via modulation of Nrf2/HO-1/Sirt1 pathway in mice. Reproductive biology. 2022 Jun; 22(2):100638. doi: 10.1016/j.repbio.2022.100638. [PMID: 35344846]
  • Jia-Wen Teng, Si-Shan Bian, Peng Kong, Yun-Gang Chen. Icariin triggers osteogenic differentiation of bone marrow stem cells by up-regulating miR-335-5p. Experimental cell research. 2022 05; 414(2):113085. doi: 10.1016/j.yexcr.2022.113085. [PMID: 35292240]
  • Jiandong Sun, Weiwei Xu, Shuyuan Zheng, Chengyu Lv, Jianmin Lin, Siqi Chen, Yonghong Qiu, Xia Jiang, Eman Draz, Shie Wang. Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway. Toxicology and applied pharmacology. 2022 04; 441(?):115969. doi: 10.1016/j.taap.2022.115969. [PMID: 35259346]
  • Linyan Cheng, Xiaoli Jin, Hao Shen, Xuanwei Chen, Jin Chen, Bin Xu, Jian Xu. Icariin attenuates thioacetamide‑induced bone loss via the RANKL‑p38/ERK‑NFAT signaling pathway. Molecular medicine reports. 2022 Apr; 25(4):. doi: 10.3892/mmr.2022.12642. [PMID: 35169865]
  • Meng Wang, Ling-Chen Wang, Xiao-Xuan Feng, Yuan Zhou, Chao-Yang Ye, Chen Wang. [Icariin improves renal interstitial fibrosis in a rat model of chronic renal failure by regulating mitochondrial dynamics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Apr; 47(8):2170-2177. doi: 10.19540/j.cnki.cjcmm.20211104.401. [PMID: 35531733]
  • Yan Zhang, Xiaoping Wu, Kaili Zhu, Shangyu Liu, Yuan Yang, Ding Yuan, Ting Wang, Yumin He, Yaoyan Dun, Jie Wu, Changcheng Zhang, Haixia Zhao. Icariin attenuates perfluorooctane sulfonate-induced testicular toxicity by alleviating Sertoli cell injury and downregulating the p38MAPK/MMP9 pathway. Food & function. 2022 Mar; 13(6):3674-3689. doi: 10.1039/d1fo04135e. [PMID: 35262540]
  • Abeer A Aljehani, Nawal A Albadr, Mohammed Z Nasrullah, Thikryat Neamatallah, Basma G Eid, Ashraf B Abdel-Naim. Icariin ameliorates metabolic syndrome-induced benign prostatic hyperplasia in rats. Environmental science and pollution research international. 2022 Mar; 29(14):20370-20378. doi: 10.1007/s11356-021-17245-4. [PMID: 34734339]
  • Ling Rui Li, Gautam Sethi, Xing Zhang, Cui Liu Liu, Yan Huang, Qun Liu, Bo Xu Ren, Feng Ru Tang. The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure. Aging. 2022 02; 14(3):1562-1588. doi: 10.18632/aging.203893. [PMID: 35165207]
  • Baolin Su, Dejin Cheng, Gangyi Chen, Shu Zhang, Liangliang Wang, Xingbo Wu, Shuifu Tang. Icariin Attenuation of Diabetic Kidney Disease Through Inhibition of Endoplasmic Reticulum Stress via G Protein-Coupled Estrogen Receptors. Journal of biomedical nanotechnology. 2022 Feb; 18(2):488-497. doi: 10.1166/jbn.2022.3242. [PMID: 35484747]
  • Li Zang, Fang Gao, Aijing Huang, Yalan Zhang, Yangyan Luo, Lijia Chen, Nan Mao. Icariin inhibits epithelial mesenchymal transition of renal tubular epithelial cells via regulating the miR-122-5p/FOXP2 axis in diabetic nephropathy rats. Journal of pharmacological sciences. 2022 Feb; 148(2):204-213. doi: 10.1016/j.jphs.2021.10.002. [PMID: 35063135]
  • Lili Hou, Ziman Lin, Anyuan Xu, Guannan Le, Lei Ge, Shuiping Liu, Azhar Muhmood, Fang Gan, Kehe Huang. Combined protective effects of icariin and selenomethionine on novel chronic tubulointerstitial nephropathy models in vivo and in vitro. The British journal of nutrition. 2022 01; 127(1):12-22. doi: 10.1017/s0007114521000787. [PMID: 33663624]
  • Zhao Ruilian, Gao Ying, Shen Hongmei, Guo Lihua. Exploration of the Effect of Icariin on Nude Mice with Lung Cancer Bone Metastasis via the OPG/RANKL/RANK System. Computational and mathematical methods in medicine. 2022; 2022(?):2011625. doi: 10.1155/2022/2011625. [PMID: 35669373]
  • Jingjing Gao, Yanjin Fu, Linliang Song, Mengsha Long, Yiyao Zhang, Jiajia Qin, Haiquan Liu. Proapoptotic Effect of Icariin on Human Ovarian Cancer Cells via the NF-[Formula: see text]B/PI3K-AKT Signaling Pathway: A Network Pharmacology-Directed Experimental Investigation. The American journal of Chinese medicine. 2022; 50(2):589-619. doi: 10.1142/s0192415x22500239. [PMID: 35114909]
  • Jia-Ying Yuan, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yan Shang. Research progress on icariin, a traditional Chinese medicine extract, in the treatment of asthma. Allergologia et immunopathologia. 2022; 50(1):9-16. doi: 10.15586/aei.v50i1.490. [PMID: 34873891]
  • Fengli Zhang, Yanfen Yin, Wenwen Xu, Yanan Song, Zhou Zhou, Xin Sun, Ping Li. Icariin inhibits gastric cancer cell growth by regulating the hsa_circ_0003159/miR-223-3p/NLRP3 signaling axis. Human & experimental toxicology. 2022 Jan; 41(?):9603271221097363. doi: 10.1177/09603271221097363. [PMID: 35532261]
  • Xiaolong Li, Yujie Wen, Liyuan Sheng, Rui Guo, Yanli Zhang, Longquan Shao. Icariin activates autophagy to trigger TGFβ1 upregulation and promote angiogenesis in EA.hy926 human vascular endothelial cells. Bioengineered. 2022 01; 13(1):164-177. doi: 10.1080/21655979.2021.2011637. [PMID: 34847836]
  • Shanshan Wang, Shengjie Wang, Xiaoning Wang, Yunteng Xu, Xin Zhang, Yidan Han, Hui Yan, Linglong Liu, Lili Wang, Hongzhi Ye, Xihai Li. Effects of Icariin on Modulating Gut Microbiota and Regulating Metabolite Alterations to Prevent Bone Loss in Ovariectomized Rat Model. Frontiers in endocrinology. 2022; 13(?):874849. doi: 10.3389/fendo.2022.874849. [PMID: 35399950]
  • Luya Pu, Qingyu Meng, Shuai Li, Bin Liu, Fan Li. Icariin arrests cell cycle progression and induces cell apoptosis through the mitochondrial pathway in human fibroblast-like synoviocytes. European journal of pharmacology. 2021 Dec; 912(?):174585. doi: 10.1016/j.ejphar.2021.174585. [PMID: 34678240]
  • Yanghua Tang, Yongfu Li, Dawei Xin, Lin Chen, Zhenfei Xiong, Xuezi Yu. Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling. Bioengineered. 2021 12; 12(1):2984-2999. doi: 10.1080/21655979.2021.1943602. [PMID: 34167449]
  • Xiaoyun Zhang, Yueping Chen, Chi Zhang, Xuan Zhang, Tian Xia, Jie Han, Shilei Song, Canhong Xu, Feng Chen. Effects of icariin on the fracture healing in young and old rats and its mechanism. Pharmaceutical biology. 2021 Dec; 59(1):1245-1255. doi: 10.1080/13880209.2021.1972121. [PMID: 34511043]
  • Xihai Li, Yunteng Xu, Hui Li, Liangliang Jia, Jie Wang, Shengxiang Liang, Aoling Cai, Xue Tan, Lili Wang, Xiaoning Wang, Yanfeng Huang, Enxiang Tao, Hongzhi Ye, Tetsuya Asakawa. Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Dec; 144(?):112259. doi: 10.1016/j.biopha.2021.112259. [PMID: 34607107]
  • Weiguo He, Huiqing Liu, Linlin Hu, Yaohui Wang, Lane Huang, Aihong Liang, Xuan Wang, Qing Zhang, Yi Chen, Yi Cao, Suyun Li, Junli Wang, Xiaocan Lei. Icariin improves testicular dysfunction via enhancing proliferation and inhibiting mitochondria-dependent apoptosis pathway in high-fat diet and streptozotocin-induced diabetic rats. Reproductive biology and endocrinology : RB&E. 2021 Nov; 19(1):168. doi: 10.1186/s12958-021-00851-9. [PMID: 34753504]
  • Yaochen Chuang, Iatkio Van, Yonghua Zhao, Youhua Xu. Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting Aβ cascade pathogenesis. Journal of chemical neuroanatomy. 2021 11; 117(?):102014. doi: 10.1016/j.jchemneu.2021.102014. [PMID: 34407393]
  • Baohua Meng, Yuansong He, Zheyi Wang, Xinqi Deng, Chuanzhen Teng, Xiao Ke, Xiaofeng Hao, Yuqing Wang, Yujue He, Yuan Wang, Chunguo Wang. An explanation for fluctuations of icariin content in Epimedium production process. Pakistan journal of pharmaceutical sciences. 2021 Nov; 34(6):2173-2180. doi: . [PMID: 35034878]
  • Wei Lin, Yin Jin, Xiang Hu, Erjiong Huang, Qihan Zhu. AMPK/PGC-1α/GLUT4-Mediated Effect of Icariin on Hyperlipidemia-Induced Non-Alcoholic Fatty Liver Disease and Lipid Metabolism Disorder in Mice. Biochemistry. Biokhimiia. 2021 Nov; 86(11):1407-1417. doi: 10.1134/s0006297921110055. [PMID: 34906049]
  • Xiu-Juan Liu, Yan-Fei Lv, Wen-Zhu Cui, Yan Li, Yang Liu, Yi-Tao Xue, Feng Dong. Icariin inhibits hypoxia/reoxygenation-induced ferroptosis of cardiomyocytes via regulation of the Nrf2/HO-1 signaling pathway. FEBS open bio. 2021 11; 11(11):2966-2976. doi: 10.1002/2211-5463.13276. [PMID: 34407320]
  • Meng Wang, Lingchen Wang, Yuan Zhou, Xiaoxuan Feng, Chaoyang Ye, Chen Wang. Icariin attenuates renal fibrosis in chronic kidney disease by inhibiting interleukin-1β/transforming growth factor-β-mediated activation of renal fibroblasts. Phytotherapy research : PTR. 2021 Nov; 35(11):6204-6215. doi: 10.1002/ptr.7256. [PMID: 34426999]
  • Jiahao Wang, Yuying Sun, Xiangtong Tian. The Inhibitory Effect of Icariin Nanoparticles on Angiogenesis in Pulmonary Fibrosis. Journal of nanoscience and nanotechnology. 2021 11; 21(11):5429-5435. doi: 10.1166/jnn.2021.19316. [PMID: 33980352]
  • Chang Li, Fei-Fei Chen, Xiao-Bin Jia, Liang Feng, Xiao-Bin Tan. [Effects and mechanism of epimedium polysaccharide on solubility of icariin and baohuoside Ⅰ]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Nov; 46(22):5825-5831. doi: 10.19540/j.cnki.cjcmm.20210317.302. [PMID: 34951171]
  • Liping Zhang, Shudong Wang, Yuying Li, Yonggang Wang, Chunzhe Dong, Hui Xu. Cardioprotective effect of icariin against myocardial fibrosis and its molecular mechanism in diabetic cardiomyopathy based on network pharmacology: Role of ICA in DCM. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Oct; 91(?):153607. doi: 10.1016/j.phymed.2021.153607. [PMID: 34411833]
  • Bin Yan, Jing-Bo Wang, Guo-Qing Tian. Efficacy of quercetin, oleanolic acid, icariin on apoptosis and mitogen-activated protein kinases signaling pathways in hippocampal neurons of Sprague-Dawley rats cultured with high glucose medium. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2021 10; 41(5):732-738. doi: 10.19852/j.cnki.jtcm.2021.05.008. [PMID: 34708631]
  • Zhanding Cui, Qian Wang, Dengliang Li, Shihui Zhao, Qian Zhang, Yuxin Tan, Qianwen Gong, Ting Liu, Jiang Shao, Shuang Zhang, Hailong Huang, Junzheng Wang, Zhihua Pei, Hao Dong, Kai Wang, Guixue Hu, Zhiyong Li. Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro. Archives of virology. 2021 Sep; 166(9):2443-2450. doi: 10.1007/s00705-021-05107-w. [PMID: 34173062]
  • Yibing Zhang, Dongsheng Xu, Peng Huang, Yang Zhang, Qi Li, Zhimin Fan, Liqun Ren. Essential role of protein kinase C βI in icariin-mediated protection against atherosclerosis. The Journal of pharmacy and pharmacology. 2021 Aug; 73(9):1169-1179. doi: 10.1093/jpp/rgab040. [PMID: 33822184]
  • Zhiqiang Qian, Ling Zhu, Yeli Li, Yiqi Li, Yuting Wu, Shu Fu, Danli Yang. Icarrin prevents cardiomyocyte apoptosis in spontaneously hypertensive rats by inhibiting endoplasmic reticulum stress pathways. The Journal of pharmacy and pharmacology. 2021 Jul; 73(8):1023-1032. doi: 10.1093/jpp/rgaa016. [PMID: 34018553]
  • Tingting Liu, Min Zhao, Yumeng Zhang, Zhaozhao Qiu, Yixin Zhang, Chunjie Zhao, Miao Wang. Pharmacokinetic-pharmacodynamic modeling analysis and anti-inflammatory effect of Wangbi capsule in the treatment of adjuvant-induced arthritis. Biomedical chromatography : BMC. 2021 Jul; 35(7):e5101. doi: 10.1002/bmc.5101. [PMID: 33625739]
  • Ruijie Wang, Bin Bao, Shujun Wang, Jeevithan Elango, Wenhui Wu. Fabrication of Chinese Traditional Medicines incorporated collagen biomaterials for human bone marrow mesenchymal stem cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111659. doi: 10.1016/j.biopha.2021.111659. [PMID: 33962310]
  • Fu-Liang Hao, Shuang Mei, Xiao Liu, Yang Liu, Xu-Dong Zhang, Fu-Sheng Dong. Icariin contributes to healing skull defects in rabbit model. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2021 06; 41(3):471-478. doi: 10.19852/j.cnki.jtcm.2021.03.016. [PMID: 34114406]
  • Xiaoang Li, Imran Khan, Wenrui Xia, Guoxin Huang, Liang Liu, Betty Yuen Kwan Law, Lin Yin, Weilin Liao, Waikit Leong, Ruixuan Han, Vincent Kam Wai Wong, Chenglai Xia, Xiaoling Guo, W L Wendy Hsiao. Icariin enhances youth-like features by attenuating the declined gut microbiota in the aged mice. Pharmacological research. 2021 06; 168(?):105587. doi: 10.1016/j.phrs.2021.105587. [PMID: 33798737]
  • Qisheng Feng, Lin Tong, Huiwen Guo, Chang Ma, Feng Qin, Zhili Xiong. Tailor-made deep eutectic solvents extraction combined with UPLC-MS/MS determination of icarrin and icarisid II in rat plasma and its comparative pharmacokinetic application. Journal of pharmaceutical and biomedical analysis. 2021 May; 199(?):114054. doi: 10.1016/j.jpba.2021.114054. [PMID: 33831735]
  • Yingxing Xu, Yaping Jiang, Bin Jia, Yingzhen Wang, Tao Li. Icariin stimulates osteogenesis and suppresses adipogenesis of human bone mesenchymal stem cells via miR-23a-mediated activation of the Wnt/β-catenin signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 May; 85(?):153485. doi: 10.1016/j.phymed.2021.153485. [PMID: 33743412]
  • Xin Liu, Zekun Liu, Yang Miao, Lin Wang, Huijun Yin. Sex hormone-like Effects of Icariin on T-cells immune modulation in spontaneously hypertensive rats. Journal of ethnopharmacology. 2021 Apr; 269(?):113717. doi: 10.1016/j.jep.2020.113717. [PMID: 33359002]
  • Chengjie Wu, Guanglu Yang, Yalan Pan, Lei Wang, Pengcheng Tu, Suyang Zheng, Yang Guo, Yong Ma. Icariin promotes the repair of PC12 cells by inhibiting endoplasmic reticulum stress. BMC complementary medicine and therapies. 2021 Feb; 21(1):69. doi: 10.1186/s12906-021-03233-1. [PMID: 33607999]
  • Min-You Qi, Ying-Hao He, Yin Cheng, Qing Fang, Ru-Yu Ma, Shao-Jie Zhou, Jia-Qi Hao. Icariin ameliorates streptozocin-induced diabetic nephropathy through suppressing the TLR4/NF-κB signal pathway. Food & function. 2021 Feb; 12(3):1241-1251. doi: 10.1039/d0fo02335c. [PMID: 33433547]
  • Kun-Mu Yang, Zhi-Hui Yang, Jiang Rui. [Icariin improves erectile function in spontaneously hypertensive rats by up-regulating Nrf2]. Zhonghua nan ke xue = National journal of andrology. 2021 Feb; 27(2):106-113. doi: . [PMID: 34914325]
  • Liping Zhou, Christina Chui-Wa Poon, Ka-Ying Wong, Sisi Cao, Xiaoli Dong, Yan Zhang, Man-Sau Wong. Icariin ameliorates estrogen-deficiency induced bone loss by enhancing IGF-I signaling via its crosstalk with non-genomic ERα signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Feb; 82(?):153413. doi: 10.1016/j.phymed.2020.153413. [PMID: 33339654]
  • Nanbu Wang, Haoyu Wang, Qi Pan, Jian Kang, Ziwen Liang, Ronghua Zhang. The Combination of β-Asarone and Icariin Inhibits Amyloid-β and Reverses Cognitive Deficits by Promoting Mitophagy in Models of Alzheimer's Disease. Oxidative medicine and cellular longevity. 2021; 2021(?):7158444. doi: 10.1155/2021/7158444. [PMID: 34887998]
  • Jianliang Gao, Shouyu Xiang, Xiao Wei, Ram Ishwar Yadav, Menghu Han, Weihao Zheng, Lili Zhao, Yichuan Shi, Yanming Cao. Icariin Promotes the Osteogenesis of Bone Marrow Mesenchymal Stem Cells through Regulating Sclerostin and Activating the Wnt/β-Catenin Signaling Pathway. BioMed research international. 2021; 2021(?):6666836. doi: 10.1155/2021/6666836. [PMID: 33553429]
  • Zhi-Ming Wu, Jun Luo, Xiao-Dong Shi, Shao-Xin Zhang, Xiao-Bo Zhu, Jian Guo. Icariin alleviates rheumatoid arthritis via regulating miR-223-3p/NLRP3 signalling axis. Autoimmunity. 2020 12; 53(8):450-458. doi: 10.1080/08916934.2020.1836488. [PMID: 33084415]
  • Zhiyong Long, Jiamin Wu, Wang Xiang, Zhican Zeng, Ganpeng Yu, Jun Li. Exploring the Mechanism of Icariin in Osteoporosis Based on a Network Pharmacology Strategy. Medical science monitor : international medical journal of experimental and clinical research. 2020 Nov; 26(?):e924699. doi: 10.12659/msm.924699. [PMID: 33230092]
  • Shuwan Wang, Jingjing Gao, Qingyu Li, Wanjun Ming, Yanjin Fu, Linliang Song, Jiajia Qin. Study on the regulatory mechanism and experimental verification of icariin for the treatment of ovarian cancer based on network pharmacology. Journal of ethnopharmacology. 2020 Nov; 262(?):113189. doi: 10.1016/j.jep.2020.113189. [PMID: 32736044]