Ficusin (BioDeep_00000861003)

Main id: BioDeep_00000000456

 

PANOMIX_OTCML-2023 Antitumor activity Volatile Flavor Compounds


代谢物信息卡片


2-Propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, .delta.-lactone

化学式: C11H6O3 (186.0316926)
中文名称: 补骨脂素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=O)OC2=CC3=C(C=CO3)C=C21
InChI: InChI=1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H

描述信息

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
D003879 - Dermatologic Agents
Psoralen (Ficusin) is a coumarin isolated from the seeds of Fructus Psoraleae. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al[1].
Psoralen (Ficusin) is a coumarin isolated from the seeds of Fructus Psoraleae. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al[1].

同义名列表

46 个代谢物同义名

2-Propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, .delta.-lactone; 2-Propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, delta-lactone; InChI=1\C11H6O3\c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11\h1-6; 5-Benzofuranacrylic acid, 6-hydroxy-, .delta.-lactone; 5-Benzofuranacrylic acid, 6-hydroxy-, delta-lactone; 6-Hydroxy-5-benzofuranacrylic acid beta-lactone; 5-19-04-00445 (Beilstein Handbook Reference); 7H-Furo(3,2-g)(1)benzopyran-7-one; 7H-Furo[3,2-g][1]benzopyran-7-one; 7H-Furo[3,2-g]benzopyran-7-one; 7H-Furo[3,2-g]chromen-7-one; furo[3,2-g]chromen-7-one; 7-furo[3,2-g]chromenone; Furo[4,5:6,7]coumarin; Furo[2.3:7.6]coumarin; Furo(4,5,6,7)coumarin; Furo(2,3,7,6)coumarin; Furo(3,2-g)-coumarin; Furo[3,2-g]coumarin; EINECS 200-639-7; NCGC00017351-01; NCGC00142529-01; Oprea1_841692; MEGxp0_001172; ACon1_001579; Furocoumarin; ZINC00120283; BRN 0152784; P8399_SIGMA; AIDS-038395; Psorline-P; AIDS038395; NSC 404562; CCRIS 4343; Psoralene; NSC404562; HSDB 3528; TNP00293; ST057250; Psoralen; Psolaren; 66-97-7; Ficusin; C09305; Psoralen; Psoralen



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(2)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

108 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Na Zhu, Li-Yuan Cheng, Xiao-Ying Zhang, Yue Zhang, Kun Zhou. [Pharmacokinetics of 11 active components of Psoraleae Fructus in normal and diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Mar; 49(5):1369-1377. doi: 10.19540/j.cnki.cjcmm.20231207.201. [PMID: 38621985]
  • Lei Yang, Zhaoyong Li, Chao Zhang, Shuofu Li, Long Chen, Shaofeng Yang, Yantao Guo. Psoralen synergizes with exosome-loaded SPC25 to alleviate senescence of nucleus pulposus cells in intervertebral disc degeneration. Journal of orthopaedic surgery and research. 2023 Oct; 18(1):622. doi: 10.1186/s13018-023-04085-w. [PMID: 37872583]
  • Nancy Tripathi, Nivedita Bhardwaj, Sanjay Kumar, Shreyans Kumar Jain. Phytochemical and pharmacological aspects of psoralen- A bioactive furanocoumarin from Psoralea corylifolia Linn. Chemistry & biodiversity. 2023 Sep; ?(?):e202300867. doi: 10.1002/cbdv.202300867. [PMID: 37752710]
  • Kexin Wang, Chuanhui Yin, Xiangmin Ye, Quanlin Chen, Jie Wu, Yupeng Chen, Yi Li, Jun Wang, Chuanzhi Duan, Aiping Lu, Daogang Guan. A Metabolic Driven Bio-Responsive Hydrogel Loading Psoralen for Therapy of Rheumatoid Arthritis. Small (Weinheim an der Bergstrasse, Germany). 2023 05; 19(21):e2207319. doi: 10.1002/smll.202207319. [PMID: 36869654]
  • Yujie Lu, Man Zhang, Jin Zhang, Min Jiang, Gang Bai. Psoralen prevents the inactivation of estradiol and treats osteoporosis via covalently targeting HSD17B2. Journal of ethnopharmacology. 2023 Mar; 311(?):116426. doi: 10.1016/j.jep.2023.116426. [PMID: 36997132]
  • Chunjian Zhao, Xin Li, Chunying Li, Shen Li, Yao Tian, TTingting Wang, Yujie Fu. Ingenious application of ethylenediaminetetraacetic acid disodium to improve the extraction yield of psoralen in fig (Ficus carica L.) leaves. Natural product research. 2023 Feb; 37(3):508-513. doi: 10.1080/14786419.2021.1980792. [PMID: 34546825]
  • Meng-Ying Chen, Qin Wang, Zhao-Jun Meng, Wei-Jie Men, Ju-Yang Huang, Bin Yu, Kun Zhou. Psoralen induces liver injury and affects hepatic bile acids metabolism in female and male C57BL/6J mice. Phytotherapy research : PTR. 2023 Feb; ?(?):. doi: 10.1002/ptr.7739. [PMID: 36724888]
  • Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh, Young-Won Chin. Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica. Journal of natural products. 2023 01; 86(1):138-148. doi: 10.1021/acs.jnatprod.2c00844. [PMID: 36529937]
  • Avantika Pandey, Madhoolika Agrawal, Shashi Bhushan Agrawal. Individual and combined effects of chromium and ultraviolet-B radiation on defense system, ultrastructural changes, and production of secondary metabolite psoralen in a medicinal plant Psoralea corylifolia L. Environmental science and pollution research international. 2023 Jan; 30(2):4372-4385. doi: 10.1007/s11356-022-22480-4. [PMID: 35971049]
  • Jin-Fa Tang, Lu Niu, Xiao-Yan Wang, Hui Zhang, Ming-Liang Zhang, Ya-Li Wu, Xiao-Fei Chen, Ke-Ran Feng, Jin-Hao Jia, Wei-Xia Li. [Comparison on distribution of 8 components from ethanol extract of Psoraleae Fructus between normal and lipopolysaccharide-induced model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Dec; 47(24):6763-6779. doi: 10.19540/j.cnki.cjcmm.20220823.501. [PMID: 36604926]
  • Cai Zhang, Jin-Quan Zhao, Jia-Xing Sun, Hui-Jun Li. Psoralen and isopsoralen from Psoraleae Fructus aroused hepatotoxicity via induction of aryl hydrocarbon receptor-mediated CYP1A2 expression. Journal of ethnopharmacology. 2022 Oct; 297(?):115577. doi: 10.1016/j.jep.2022.115577. [PMID: 35872289]
  • Youji Jia, Guodong Wang, Wei Yan, Bo Kong, Yong Xu, Chenglong Wang, Dezhi Tang, Xiaobing Xi. Psoralen suppresses the phosphorylation of amyloid precursor protein (APP) to inhibit myelosuppression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113381. doi: 10.1016/j.biopha.2022.113381. [PMID: 36076476]
  • Min Jiang, Xiaoying Wang, Bin Lv, Yujie Lu, Xianghui Ma, Wenjuan Liu, Gang Bai, Xiumei Gao. Psoralen induces hepatotoxicity by covalently binding to glutathione-S-transferases and the hepatic cytochrome P450. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154165. doi: 10.1016/j.phymed.2022.154165. [PMID: 35792449]
  • Kui Huang, Bo Wu, Zhuhu Hou, Akhlaq Ahmad, Mushtaq Ahmed, Ayesha Ali Khan, Feng Tian, Fan Cheng, Wei Chu, Ke Deng. Psoralen downregulates osteoarthritis chondrocyte inflammation via an estrogen-like effect and attenuates osteoarthritis. Aging. 2022 08; 14(16):6716-6726. doi: 10.18632/aging.204245. [PMID: 36036756]
  • Atikanmu Wahefu, Rahima Abdulla, Xueying Lu, Yongqiang Liu, Haji Akber Aisa. Chemical profiling of composite prescription caraway and quantification of three pairs isomeric components in caraway administered rat plasma by tandem mass spectrometry. Journal of separation science. 2022 Aug; 45(16):3082-3094. doi: 10.1002/jssc.202200155. [PMID: 35771622]
  • Dan-Ni Wang, Jia-Ming Guo, Xin Chai, Jing Yang, Yue-Fei Wang. [Quality evaluation of Psoraleae Fructus based on QAMS method and TLC identification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Aug; 47(15):4089-4097. doi: 10.19540/j.cnki.cjcmm.20220421.202. [PMID: 36046899]
  • Ruili Yu, Yingli Yu, Shijia Su, Lin Zhao, Qin Wang, Yue Zhang, Lei Song, Kun Zhou. Psoralen induces liver injuries through endoplasmic reticulum stress signaling in female mice. Drug and chemical toxicology. 2022 Jul; 45(4):1818-1824. doi: 10.1080/01480545.2021.1881537. [PMID: 33557643]
  • Sitong Sun, Manshu Wang, Yu Yuan, Shuo Wang, Haoran Ding, Chenrui Liang, Xiaomeng Li, Simiao Fan, Yubo Li. A new strategy for the rapid identification and validation of direct toxicity targets of psoralen-induced hepatotoxicity. Toxicology letters. 2022 Jun; 363(?):11-26. doi: 10.1016/j.toxlet.2022.05.002. [PMID: 35597499]
  • Xinna Ma, Heng Li, Ying Gong, Feifei Liu, Xiankun Tong, Fenghua Zhu, Xiaoqian Yang, Li Yang, Jianping Zuo. Psoralen inhibits hepatitis B viral replication by down-regulating the host transcriptional machinery of viral promoters. Virologica Sinica. 2022 Apr; 37(2):256-265. doi: 10.1016/j.virs.2022.01.027. [PMID: 35305922]
  • Yuhao Wang, Yonglun Wang, Fang Li, Jie Zou, Xiaoqian Li, Mengxia Xu, Daojiang Yu, Yijia Ma, Wei Huang, Xiaodong Sun, Yuanyuan Zhang. Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells. Cells. 2022 03; 11(7):. doi: 10.3390/cells11071067. [PMID: 35406631]
  • Neha Mahajan, Bhupendra Koul, Jasleen Kaur, Mahendra Bishnoi, Pankaj Gupta, Amit Kumar, Bhahwal Ali Shah, Iqra Mubeen, Ashutosh Kumar Rai, Ram Prasad, Joginder Singh. Antiobesity Potential of Bioactive Constituents from Dichloromethane Extract of Psoralea corylifolia L. Seeds. BioMed research international. 2022; 2022(?):9504787. doi: 10.1155/2022/9504787. [PMID: 36060144]
  • Shubo Li, Hongqin Tu. Psoralen inhibits the proliferation and promotes apoptosis through endoplasmic reticulum stress in human osteosarcoma cells. Folia histochemica et cytobiologica. 2022; 60(1):101-109. doi: 10.5603/fhc.a2022.0010. [PMID: 35257357]
  • Fengjie Liu, Lihong Li, Meng Lan, Tengteng Zou, Zhaodi Kong, Tiange Cai, Xiaoyu Wu, Yu Cai. Psoralen-loaded polymeric lipid nanoparticles combined with paclitaxel for the treatment of triple-negative breast cancer. Nanomedicine (London, England). 2021 11; 16(27):2411-2430. doi: 10.2217/nnm-2021-0241. [PMID: 34749510]
  • Hua Liu, Yingjie Xu, Qi Cui, Ning Liu, Fuhang Chu, Beibei Cong, Yingtao Wu. Effect of Psoralen on the Intestinal Barrier and Alveolar Bone Loss in Rats With Chronic Periodontitis. Inflammation. 2021 Oct; 44(5):1843-1855. doi: 10.1007/s10753-021-01462-7. [PMID: 33839980]
  • Ge-Zi Shi, Di Song, Peng-Yan Li, Shuai-Shuai Chen, Le Zhang, Shan-Shan Li, Xiao-He Xiao, Xu-Hua Qin, Jia-Bo Wang. Screening of hepatotoxic compounds in Psoralea corylifolia L., a traditional Chinese herbal and dietary supplement, using high-resolution mass spectrometry and high-content imaging. Biomedical chromatography : BMC. 2021 Sep; 35(9):e5140. doi: 10.1002/bmc.5140. [PMID: 33830528]
  • Wenying Gao, Zhenglong Jin, Yanxia Zheng, Youjia Xu. Psoralen inhibits the inflammatory response and mucus production in allergic rhinitis by inhibiting the activator protein 1 pathway and the downstream expression of cystatin‑SN. Molecular medicine reports. 2021 Sep; 24(3):. doi: 10.3892/mmr.2021.12291. [PMID: 34278468]
  • Lihong Li, Tengteng Zou, Min Liang, Yaroslav Mezhuev, Aristidis Michael Tsatsakis, Aleksandra Buha Đorđević, Meng Lan, Fengjie Liu, Tiange Cai, Peng Gong, Yu Cai. Screening of metabolites in the treatment of liver cancer xenografts HepG2/ADR by psoralen-loaded lipid nanoparticles. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2021 Aug; 165(?):337-344. doi: 10.1016/j.ejpb.2021.05.025. [PMID: 34062256]
  • Yang Gao, Meng-Meng Wei, Si-Yang Wu, Zheng Yuan, Shu-Yao Wang, Chen Kang, Wei Yang, Ying-Fei Li, Chuan Li. [Pharmacokinetic characteristics of psoralen,isopsoralen,psoralenoside and isopsoralenoside in rats after oral administration of Psoraleae Fructus extract]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Aug; 46(16):4244-4251. doi: 10.19540/j.cnki.cjcmm.20210318.202. [PMID: 34467739]
  • Juyang Huang, Qin Wang, Mengying Chen, Yanan Bi, Hong Shi, Kun Zhou. Effects of psoralen on hepatic bile acid transporters in rats. Human & experimental toxicology. 2021 Jun; 40(6):1012-1021. doi: 10.1177/0960327120979346. [PMID: 33317360]
  • Carter R Ellis, Dirk M Elston. Psoralen-Induced Phytophotodermatitis. Dermatitis : contact, atopic, occupational, drug. 2021 May; 32(3):140-143. doi: 10.1097/der.0000000000000691. [PMID: 33273237]
  • Xiaoyu Sui, Tingting Liu, Jicheng Liu, Jie Zhang, Honglian Zhang, Huiyu Wang, Ying Yang. Ultrasonic-enhanced surface-active ionic liquid-based extraction and defoaming for the extraction of psoralen and isopsoralen from Psoralea corylifolia seeds. Ultrasonics sonochemistry. 2020 Dec; 69(?):105263. doi: 10.1016/j.ultsonch.2020.105263. [PMID: 32711373]
  • Yongtao Lin, Lili Zhong, Hailun Li, Yong Xu, Xiang Li, Donghui Zheng. Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874. BMC pharmacology & toxicology. 2020 07; 21(1):52. doi: 10.1186/s40360-020-00434-1. [PMID: 32698907]
  • Zhi-Xing Zhou, Li Yang, Li-Yuan Cheng, Ying-Li Yu, Lei Song, Kun Zhou, Ying-Liang Wu, Yue Zhang. Simultaneous characterization of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry for application in sex-related differences in pharmacokinetics. Journal of separation science. 2020 Jul; 43(14):2804-2816. doi: 10.1002/jssc.202000286. [PMID: 32384213]
  • Pei-Shi Liang, Wang Zhou, Zhen-Zhou Jiang, Lu-Yong Zhang. [Mechanism of psoralen in aggravating hepatotoxicity induced by CCl_4 by delaying liver regeneration]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Jun; 45(12):2916-2923. doi: 10.19540/j.cnki.cjcmm.20200115.401. [PMID: 32627467]
  • Christina L Dean, Jay W Hooper, John M Dye, Samantha E Zak, Scott A Koepsell, Laurence Corash, Richard J Benjamin, Steve Kwilas, Shannon Bonds, Anne M Winkler, Colleen S Kraft. Characterization of Ebola convalescent plasma donor immune response and psoralen treated plasma in the United States. Transfusion. 2020 05; 60(5):1024-1031. doi: 10.1111/trf.15739. [PMID: 32129478]
  • Xi-Yang Tang, Zi-Qin Dai, Qing-Chang Wu, Jia-Xing Zeng, Meng-Xue Gao, Hui-Hui Xiao, Zhi-Hong Yao, Yi Dai, Xin-Sheng Yao. Simultaneous determination of multiple components in rat plasma and pharmacokinetic studies at a pharmacodynamic dose of Xian-Ling-Gu-Bao capsule by UPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 177(?):112836. doi: 10.1016/j.jpba.2019.112836. [PMID: 31473481]
  • Abhinay Thakur, Rohit Sharma, Vivek Sheel Jaswal, Eugenie Nepovimova, Ashun Chaudhary, Kamil Kuca. Psoralen: A Biologically Important Coumarin with Emerging Applications. Mini reviews in medicinal chemistry. 2020; 20(18):1838-1845. doi: 10.2174/1389557520666200429101053. [PMID: 32348216]
  • Yingli Yu, Ruili Yu, Weijie Men, Panyang Zhang, Yue Zhang, Lei Song, Kun Zhou. Psoralen induces hepatic toxicity through PERK and ATF6 related ER stress pathways in HepG2 cells. Toxicology mechanisms and methods. 2020 Jan; 30(1):39-47. doi: 10.1080/15376516.2019.1650150. [PMID: 31364909]
  • Lei Song, Bin Yu, Li Yang, Zhao-Xin Wang, Yue Zhang, Ying-Li Yu, Kun Zhou. The mechanism of Psoralen and Isopsoralen hepatotoxicity as revealed by hepatic gene expression profiling in SD rats. Basic & clinical pharmacology & toxicology. 2019 Dec; 125(6):527-535. doi: 10.1111/bcpt.13287. [PMID: 31271704]
  • Lu Liu, Lei Zhang, Ze-Xu Cui, Xiao-Yan Liu, Wei Xu, Xiu-Wei Yang. Transformation of Psoralen and Isopsoralen by Human Intestinal Microbial In Vitro, and the Biological Activities of Its Metabolites. Molecules (Basel, Switzerland). 2019 Nov; 24(22):. doi: 10.3390/molecules24224080. [PMID: 31718071]
  • Unwoo Kang, Ah-Reum Han, Yangkang So, Chang Hyun Jin, Seung Mok Ryu, Dongho Lee, Eun Kyoung Seo. Furanocoumarins from the Roots of Angelica dahurica with Inhibitory Activity against Intracellular Reactive Oxygen Species Accumulation. Journal of natural products. 2019 09; 82(9):2601-2607. doi: 10.1021/acs.jnatprod.9b00547. [PMID: 31464439]
  • Diána Kerekes, Attila Csorba, Beáta Gosztola, Éva Németh-Zámbori, Tivadar Kiss, Dezső Csupor. Furocoumarin Content of Fennel-Below the Safety Threshold. Molecules (Basel, Switzerland). 2019 Aug; 24(15):. doi: 10.3390/molecules24152844. [PMID: 31387269]
  • Xiaomin Wang, Peike Peng, Zhiqiang Pan, Zhaoqin Fang, Wenli Lu, Xiaomei Liu. Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells. Biological research. 2019 Jul; 52(1):34. doi: 10.1186/s40659-019-0241-8. [PMID: 31277690]
  • Li-Shan Zhou, Su-Qi Yan, Xiao-Li Xiong, Juan Huang, Huan Qin, Ling-Ling Zhang, Lin-Li Zhang, Jian-Qiao Tang. [Psoralen and isopsoralen improve lipid metabolism disorder via inhibition of NF-κB activation in LO2 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 May; 44(10):2118-2123. doi: 10.19540/j.cnki.cjcmm.20190129.004. [PMID: 31355570]
  • Manling Du, Yong Ouyang, Fansu Meng, Xingwang Zhang, Qianqian Ma, Yong Zhuang, Hui Liu, Mujuan Pang, Tiange Cai, Yu Cai. Polymer-lipid hybrid nanoparticles: A novel drug delivery system for enhancing the activity of Psoralen against breast cancer. International journal of pharmaceutics. 2019 Apr; 561(?):274-282. doi: 10.1016/j.ijpharm.2019.03.006. [PMID: 30851393]
  • Yu Wang, Hong Zhang, Jia-Ming Jiang, Dan Zheng, Yu-Yu Chen, Shi-Jie Wan, Hong-Sheng Tan, Li-Ming Tang, Hong-Xi Xu. Hepatotoxicity induced by psoralen and isopsoralen from Fructus Psoraleae: Wistar rats are more vulnerable than ICR mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Mar; 125(?):133-140. doi: 10.1016/j.fct.2018.12.047. [PMID: 30597224]
  • Jie Du, Chun-Hua Wang, Jing Yang, Xin He, Xiao-Liang Han, Cong-Cong Li, Xin Chai, Yue-Fei Wang, Yan Zhu, Zheng Li. Chemical constituents from the fruits of Psoralea corylifolia and their protective effects on ionising radiation injury. Natural product research. 2019 Mar; 33(5):673-680. doi: 10.1080/14786419.2017.1405407. [PMID: 29156966]
  • Jinwei Gao, Jinbo Yu, Panpan Xu, Jinmei Chen, Guanghui Gao, Binglong Li, Lixin Sun. Established UPLC-MS/MS procedure for multicomponent quantitative analysis in rat plasma: A contrastive pharmacokinetics study of Qiangshen tablet in normal and kidney yang deficiency syndrome models. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Feb; 1106-1107(?):35-42. doi: 10.1016/j.jchromb.2018.12.031. [PMID: 30639948]
  • Huiying Li, Dongfang Meng, Xiaorui Zhang, Dong Yuan. Effect of psoralen on the expression of PPARγ, osteocalcin, and trabecular bone area in rabbits with steroid-induced avascular necrosis of the femoral head. Journal of orthopaedic surgery and research. 2019 Jan; 14(1):11. doi: 10.1186/s13018-018-1054-0. [PMID: 30621711]
  • Yueling Yuan, Tiange Cai, Richard Callaghan, Qianwen Li, Yinghong Huang, Bingyue Wang, Qingqing Huang, Manling Du, Qianqian Ma, Peter Chiba, Yu Cai. Psoralen-loaded lipid-polymer hybrid nanoparticles enhance doxorubicin efficacy in multidrug-resistant HepG2 cells. International journal of nanomedicine. 2019; 14(?):2207-2218. doi: 10.2147/ijn.s189924. [PMID: 30988617]
  • Jinlan Lu, Ling Liu, Xingyu Zhu, Li Wu, Zhipeng Chen, Zisheng Xu, Weidong Li. Evaluation of the Absorption Behavior of Main Component Compounds of Salt-Fried Herb Ingredients in Qing'e Pills by Using Caco-2 Cell Model. Molecules (Basel, Switzerland). 2018 Dec; 23(12):. doi: 10.3390/molecules23123321. [PMID: 30558187]
  • U V Shivasaraun, Raman Sureshkumar, Chenmala Karthika, Nethravathi Puttappa. Flavonoids as adjuvant in psoralen based photochemotherapy in the management of vitiligo/leucoderma. Medical hypotheses. 2018 Dec; 121(?):26-30. doi: 10.1016/j.mehy.2018.09.011. [PMID: 30396481]
  • Yuzhu Zhang, Jingjing Wu, Yue Zhou, Yulian Yin, Hongfeng Chen. Effects of psoralen on the pharmacokinetics of anastrozole in rats. Pharmaceutical biology. 2018 Dec; 56(1):433-439. doi: 10.1080/13880209.2018.1501584. [PMID: 30345900]
  • Qingqing Huang, Tiange Cai, Qianwen Li, Yinghong Huang, Qian Liu, Bingyue Wang, Xi Xia, Qi Wang, John C C Whitney, Susan P C Cole, Yu Cai. Preparation of psoralen polymer-lipid hybrid nanoparticles and their reversal of multidrug resistance in MCF-7/ADR cells. Drug delivery. 2018 Nov; 25(1):1056-1066. doi: 10.1080/10717544.2018.1464084. [PMID: 29695174]
  • Tesfahun Dessale Admasu, Krishna Chaithanya Batchu, Diogo Barardo, Li Fang Ng, Vanessa Yuk Man Lam, Linfan Xiao, Amaury Cazenave-Gassiot, Markus R Wenk, Nicholas S Tolwinski, Jan Gruber. Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling. Developmental cell. 2018 10; 47(1):67-79.e5. doi: 10.1016/j.devcel.2018.09.001. [PMID: 30269951]
  • Xiaohong Wang, Chengfeng Xu, Yitong Hua, Kai Cheng, Yingzhe Zhang, Jian Liu, Yong Han, Song Liu, Guoqiang Zhang, Shujian Xu, Zhenlin Yang. Psoralen induced cell cycle arrest by modulating Wnt/β-catenin pathway in breast cancer cells. Scientific reports. 2018 09; 8(1):14001. doi: 10.1038/s41598-018-32438-7. [PMID: 30228287]
  • Yue Zhang, Qin Wang, Zhao-Xin Wang, Ya-Nan Bi, Xiao-Mei Yuan, Lei Song, Miao-Miao Jiang, Li-Kang Sun, Kun Zhou. A Study of NMR-Based Hepatic and Serum Metabolomics in a Liver Injury Sprague-Dawley Rat Model Induced by Psoralen. Chemical research in toxicology. 2018 09; 31(9):852-860. doi: 10.1021/acs.chemrestox.8b00082. [PMID: 30132663]
  • Yueling Yuan, Peter Chiba, Tiange Cai, Richard Callaghan, Li Bai, Susan P C Cole, Yu Cai. Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells. Oncology reports. 2018 Aug; 40(2):1055-1063. doi: 10.3892/or.2018.6492. [PMID: 29901161]
  • Reina Omura, Junko Sowa-Osako, Kazuyoshi Fukai, Nao Kusutani, Yasunobu Takeoka, Hideo Koh, Masahiko Ohsawa, Keiji Iwatsuki, Daisuke Tsuruta, Toshihisa Hamada. Promising therapeutic option for cutaneous plasmacytosis: 308-nm excimer lamp. The Journal of dermatology. 2018 Aug; 45(8):e215-e216. doi: 10.1111/1346-8138.14262. [PMID: 29464763]
  • Chia-Hsin Lin, Shinji Funayama, Shu-Fen Peng, Chao-Lin Kuo, Jing-Gung Chung. The ethanol extraction of prepared Psoralea corylifolia induces apoptosis and autophagy and alteres genes expression assayed by cDNA microarray in human prostate cancer PC-3 cells. Environmental toxicology. 2018 Jul; 33(7):770-788. doi: 10.1002/tox.22564. [PMID: 29667321]
  • Li Yin, Guangxian Pang, Chao Niu, Maidina Habasi, Jun Dou, Haji Akber Aisa. A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells. International journal of molecular medicine. 2018 Jun; 41(6):3727-3735. doi: 10.3892/ijmm.2018.3529. [PMID: 29512683]
  • Jin-Ping Li, Bao-Ping Xie, Wen-Juan Zhang, Li-Ying Shi, Wei-Juan Li, Ying Zeng, Guo-Xing Gan, Yu-Hong Li. [Psoralen inhibits RAW264.7 differentiation into osteoclasts and bone resorption by regulating CD4+T cell differentiation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Mar; 43(6):1228-1234. doi: 10.19540/j.cnki.cjcmm.20180104.017. [PMID: 29676133]
  • Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm. 2018 Feb; 9(2):371-382. doi: 10.1039/c7md00388a. [PMID: 30108931]
  • Lijuan Chai, Kun Zhou, Shaoxia Wang, Han Zhang, Na Fan, Jie Li, Xiaofeng Tan, Limin Hu, Xiang Fan. Psoralen and Bakuchiol Ameliorate M-CSF Plus RANKL-Induced Osteoclast Differentiation and Bone Resorption Via Inhibition of AKT and AP-1 Pathways in Vitro. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 48(5):2123-2133. doi: 10.1159/000492554. [PMID: 30110702]
  • Xiaotian Li, Chunbo Yu, Yi Hu, Xinyi Xia, Yue Liao, Jing Zhang, Huiwen Chen, Weili Lu, Wei Zhou, Zhongchen Song. New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects. Frontiers in cellular and infection microbiology. 2018; 8(?):178. doi: 10.3389/fcimb.2018.00178. [PMID: 29922598]
  • Wenwei Zheng, Pingdong Lin, Yuhuan Ma, Xiang Shao, Houhuang Chen, Da Chen, Xianxiang Liu, Xihai Li, Hongzhi Ye. Psoralen promotes the expression of cyclin D1 in chondrocytes via the Wnt/β-catenin signaling pathway. International journal of molecular medicine. 2017 Nov; 40(5):1377-1384. doi: 10.3892/ijmm.2017.3148. [PMID: 28949389]
  • R V Bandeira Reidel, S Giovanelli, A Pipitone, P Minissale, L Pistelli. Phytochemical study of Bituminaria basaltica aerial parts, an Italian endemism. Natural product research. 2017 Oct; 31(20):2375-2380. doi: 10.1080/14786419.2017.1308368. [PMID: 28349701]
  • Toru Takahashi, Aya Okiura, Masahiro Kohno. Phenylpropanoid composition in fig (Ficus carica L.) leaves. Journal of natural medicines. 2017 Oct; 71(4):770-775. doi: 10.1007/s11418-017-1093-6. [PMID: 28589249]
  • Xu Ling, Li Zou, Zilin Chen. Polymeric monolith column composited with multiwalled carbon nanotubes-β-cyclodextrin for the selective extraction of psoralen and isopsoralen. Journal of separation science. 2017 Sep; 40(18):3718-3724. doi: 10.1002/jssc.201700562. [PMID: 28715109]
  • Aihong Yang, Junxiu Chen, Yetao Ma, Lili Wang, Yaowen Fan, Xin He. Studies on the metabolites difference of psoralen/isopsoralen in human and six mammalian liver microsomes in vitro by UHPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2017 Jul; 141(?):200-209. doi: 10.1016/j.jpba.2017.04.026. [PMID: 28448889]
  • Jia-Rong Gao, Shuang-Zhi Xu, Yan-Quan Han, Liang-Bing Wei, Hui Jiang, Jun-Mei Song, Xue Xue. [Determination and pharmacokinetics of main components for Psoralea corylifolia-Myristica fragrants drug pair by using UPLC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 May; 42(9):1782-1786. doi: 10.19540/j.cnki.cjcmm.2017.0071. [PMID: 29082707]
  • Juan Carlos Romero-Benavides, Ana Lucía Ruano, Ronal Silva-Rivas, Paola Castillo-Veintimilla, Sara Vivanco-Jaramillo, Natalia Bailon-Moscoso. Medicinal plants used as anthelmintics: Ethnomedical, pharmacological, and phytochemical studies. European journal of medicinal chemistry. 2017 Mar; 129(?):209-217. doi: 10.1016/j.ejmech.2017.02.005. [PMID: 28231520]
  • Hongyu Zhang, Kai Zhang, Zhe Li, Jihui Zhao, Yongtai Zhang, Nianping Feng. In Vivo Microdialysis for Dynamic Monitoring of the Effectiveness of Nano-liposomes as Vehicles for Topical Psoralen Application. Biological & pharmaceutical bulletin. 2017; 40(11):1996-2000. doi: 10.1248/bpb.b17-00302. [PMID: 29093350]
  • Shuqing Chen, Yongqian Wang, Yubin Yang, Ting Xiang, Jiahui Liu, Houming Zhou, Xinlin Wu. Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway. BioMed research international. 2017; 2017(?):3524307. doi: 10.1155/2017/3524307. [PMID: 28349059]
  • Ling Liu, Ze-Bin Weng, Heng Wang, Xing-Yu Zhu, Zhi-Peng Chen, Li Wu, Wei-Dong Li. [Analysis on pharmacokinetics-pharmacodynamics correlation of effective ingredients of Qing'e wan]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Dec; 41(23):4436-4441. doi: 10.4268/cjcmm20162323. [PMID: 28933124]
  • Britt Van Aelst, Rosalie Devloo, Pierre Zachée, Ruben t'Kindt, Koen Sandra, Philippe Vandekerckhove, Veerle Compernolle, Hendrik B Feys. Psoralen and Ultraviolet A Light Treatment Directly Affects Phosphatidylinositol 3-Kinase Signal Transduction by Altering Plasma Membrane Packing. The Journal of biological chemistry. 2016 Nov; 291(47):24364-24376. doi: 10.1074/jbc.m116.735126. [PMID: 27687726]
  • Chao Niu, Guang Xian Pang, Gen Li, Jun Dou, Li Fei Nie, Helimay Himit, Madina Kabas, Haji Akber Aisa. Synthesis and biological evaluation of furocoumarin derivatives on melanin synthesis in murine B16 cells for the treatment of vitiligo. Bioorganic & medicinal chemistry. 2016 11; 24(22):5960-5968. doi: 10.1016/j.bmc.2016.09.056. [PMID: 27713014]
  • Valeria Yukari Abe, Celso Eduardo Benedetti. Additive roles of PthAs in bacterial growth and pathogenicity associated with nucleotide polymorphisms in effector-binding elements of citrus canker susceptibility genes. Molecular plant pathology. 2016 10; 17(8):1223-36. doi: 10.1111/mpp.12359. [PMID: 26709719]
  • Qunqun Guo, Guicai Du, Hongwei He, Hongkai Xu, Daosen Guo, Ronggui Li. Two nematicidal furocoumarins from Ficus carica L. leaves and their physiological effects on pine wood nematode (Bursaphelenchus xylophilus). Natural product research. 2016 Sep; 30(17):1969-73. doi: 10.1080/14786419.2015.1094804. [PMID: 26479900]
  • Valeria Brazzelli, Sara Grassi, Serena Merante, Vincenzo Grasso, Rachele Ciccocioppo, Grazia Bossi, Giovanni Borroni. Narrow-band UVB phototherapy and psoralen-ultraviolet A photochemotherapy in the treatment of cutaneous mastocytosis: a study in 20 patients. Photodermatology, photoimmunology & photomedicine. 2016 Sep; 32(5-6):238-246. doi: 10.1111/phpp.12248. [PMID: 27353865]
  • Santiagu Stephen Irudayaraj, Antony Stalin, Christudas Sunil, Veeramuthu Duraipandiyan, Naif Abdullah Al-Dhabi, Savarimuthu Ignacimuthu. Antioxidant, antilipidemic and antidiabetic effects of ficusin with their effects on GLUT4 translocation and PPARγ expression in type 2 diabetic rats. Chemico-biological interactions. 2016 Aug; 256(?):85-93. doi: 10.1016/j.cbi.2016.06.023. [PMID: 27350165]
  • Qian qian Gao, Cui ping Yan, Zi sheng Xu, Yu Wu, Ze bin Weng, Gen hua Zhao, Liu jie Zhang, Jia yu He, Bao chang Cai, Zhi peng Chen, Wei dong Li. Evaluation of the influence of salt processing on pharmacokinetics of psoralen and isopsoralen in Psoralea corylifolia L. Biomedical chromatography : BMC. 2016 Apr; 30(4):528-35. doi: 10.1002/bmc.3578. [PMID: 26248603]
  • Xiaomei Yuan, Yanan Bi, Zeman Yan, Weiling Pu, Yuhong Li, Kun Zhou. Psoralen and Isopsoralen Ameliorate Sex Hormone Deficiency-Induced Osteoporosis in Female and Male Mice. BioMed research international. 2016; 2016(?):6869452. doi: 10.1155/2016/6869452. [PMID: 27239473]
  • Guangguo Tan, Tiehong Yang, Huayan Miao, Hao Chen, Yifeng Chai, Hong Wu. Characterization of Compounds in Psoralea corylifolia Using High-Performance Liquid Chromatography Diode Array Detection, Time-of-Flight Mass Spectrometry and Quadrupole Ion Trap Mass Spectrometry. Journal of chromatographic science. 2015 Oct; 53(9):1455-62. doi: 10.1093/chromsci/bmv038. [PMID: 25903696]
  • Kang Xu, Xin Pan, Yanjun Sun, Wei Xu, Lucy Njunge, Li Yang. Psoralen activates cartilaginous cellular functions of rat chondrocytes in vitro. Pharmaceutical biology. 2015 Jul; 53(7):1010-5. doi: 10.3109/13880209.2014.952835. [PMID: 25471084]
  • Behrooz Mohammadparast, Ali Reza Rustaiee, Mousa Rasouli, Sannaz Zardari, Veena Agrawal. In vitro enhancement of psoralen as an important anticancer compound in Psoralea corylifolia through precursor feeding. Pharmaceutical biology. 2015 May; 53(5):735-8. doi: 10.3109/13880209.2014.942786. [PMID: 25331001]
  • Xiang-hui Han, Chun-li Wang, Yan Xie, Jiang Ma, Xiao-hui Zhang, Qian-wen Hu, Ge Lin, Sheng Liu, Jin-gen Lu. Anti-metastatic effect and mechanisms of Wenshen Zhuanggu Formula in human breast cancer cells. Journal of ethnopharmacology. 2015 Mar; 162(?):39-46. doi: 10.1016/j.jep.2014.12.036. [PMID: 25554638]
  • Lisa Ng, Timothy P Crowley, Sanjay Varma. Home sunbed and psoralen use: a burning issue. Journal of burn care & research : official publication of the American Burn Association. 2015 Mar; 36(2):e105-6. doi: 10.1097/bcr.0000000000000091. [PMID: 25084491]
  • Alejandro Madrid Villegas, Katy Díaz Peralta, César González Tapia, Karen Catalán Marín, Luis Espinoza Catalán. Antiphytopathogenic activity of Psoralea glandulosa (Fabaceae) against Botrytis cinerea and Phytophthora cinnamomi. Natural product research. 2015; 29(6):586-8. doi: 10.1080/14786419.2014.955486. [PMID: 25184663]
  • Jie Guo, Dianrong Song, Fang Han, Wei Zhang, Yanan Wang, Yuhua Wang, Wenxin Du. In vitro transport mechanism of psoralen in a human placental cell line (BeWo cells). Planta medica. 2015 Jan; 81(2):138-44. doi: 10.1055/s-0034-1396147. [PMID: 25626141]
  • Honghui Lu, Lihai Zhang, Daohong Liu, Peifu Tang, Feixiang Song. Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. African health sciences. 2014 Sep; 14(3):641-7. doi: 10.4314/ahs.v14i3.20. [PMID: 25352883]
  • Yong-Tai Zhang, Li-Na Shen, Zhong-Hua Wu, Ji-Hui Zhao, Nian-Ping Feng. Comparison of ethosomes and liposomes for skin delivery of psoralen for psoriasis therapy. International journal of pharmaceutics. 2014 Aug; 471(1-2):449-52. doi: 10.1016/j.ijpharm.2014.06.001. [PMID: 24907596]
  • Eunhui Seo, Eun-Kyu Lee, Cheol Soon Lee, Kwang-Hoon Chun, Mi-Young Lee, Hee-Sook Jun. Psoralea corylifolia L. seed extract ameliorates streptozotocin-induced diabetes in mice by inhibition of oxidative stress. Oxidative medicine and cellular longevity. 2014; 2014(?):897296. doi: 10.1155/2014/897296. [PMID: 24803987]
  • Yong-Tai Zhang, Li-Na Shen, Ji-Hui Zhao, Nian-Ping Feng. Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis. International journal of nanomedicine. 2014; 9(?):669-78. doi: 10.2147/ijn.s57314. [PMID: 24489470]
  • Yue-Fei Wang, Ya-Nan Liu, Wen Xiong, Dong-Mei Yan, Yan Zhu, Xiu-Mei Gao, Yan-Tong Xu, Ai-Di Qi. A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract. Journal of ethnopharmacology. 2014; 151(1):609-17. doi: 10.1016/j.jep.2013.11.013. [PMID: 24315982]
  • Vasumathy Rajan, Jyoti Tripathi, Prasad Variyar, Badri Narain Pandey. Mechanism of cytotoxicity by Psoralea corylifolia extract in human breast carcinoma cells. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2014; 33(3):265-77. doi: 10.1615/jenvironpatholtoxicoloncol.2014011391. [PMID: 25272064]
  • Hualiang Jin, Limin Wang, Changqing Xu, Bei Li, Qingli Luo, Jinfeng Wu, Yubao Lv, Genfa Wang, Jingcheng Dong. Effects of Psoraleae fructus and its major component psoralen on Th2 response in allergic asthma. The American journal of Chinese medicine. 2014; 42(3):665-78. doi: 10.1142/s0192415x14500438. [PMID: 24871658]
  • Qian Wan, Hua Lu, Yanli Deng, Limei Liang. [Psoralen induces rat mesenchymal stem cell differentiation towards male germ cells in vitro]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2013 Dec; 33(12):1723-6. doi: ". [PMID: 24369232]
  • Xiao-Mei Zhuang, Yu-Huan Zhong, Wei-Bin Xiao, Hua Li, Chuang Lu. Identification and characterization of psoralen and isopsoralen as potent CYP1A2 reversible and time-dependent inhibitors in human and rat preclinical studies. Drug metabolism and disposition: the biological fate of chemicals. 2013 Nov; 41(11):1914-22. doi: 10.1124/dmd.113.053199. [PMID: 23975028]