Graveoline (BioDeep_00000008256)

 

Secondary id: BioDeep_00000015301

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


2-(2H-1,3-benzodioxol-5-yl)-1-methyl-1,4-dihydroquinolin-4-one

化学式: C17H13NO3 (279.0895388)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2%

分子结构信息

SMILES: Cn1c(-c2ccc3c(c2)OCO3)cc(=O)c2ccccc21
InChI: InChI=1S/C17H13NO3/c1-18-13-5-3-2-4-12(13)15(19)9-14(18)11-6-7-16-17(8-11)21-10-20-16/h2-9H,10H2,1H3

描述信息

Graveoline is found in herbs and spices. Graveoline is an alkaloid from Ruta graveolens (rue).
Alkaloid from Ruta graveolens (rue). Graveoline is found in herbs and spices.
Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity[1].
Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity[1].

同义名列表

8 个代谢物同义名

2-(2H-1,3-benzodioxol-5-yl)-1-methyl-1,4-dihydroquinolin-4-one; 2-(1,3-Benzodioxol-5-yl)-1-methyl-4(1H)-quinolinone, 9ci; 1-Methyl-2-(3,4-methylenedioxyphenyl)-4(1H)-quinolinone; Alkaloid from ruta angustifolia plant; Graveoline; Foliosine; Graveolin; Rutamine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Laina Zarisa Mohd Kamal, Mowaffaq Adam Ahmed Adam, Siti Nurfatimah Mohd Shahpudin, Ahmad Naqeeb Shuib, Rosline Sandai, Norazian Mohd Hassan, Yasser Tabana, Dayang Fredalina Basri, Leslie Thian Lung Than, Doblin Sandai. Identification of Alkaloid Compounds Arborinine and Graveoline from Ruta angustifolia (L.) Pers for their Antifungal Potential against Isocitrate lyase (ICL1) gene of Candida albicans. Mycopathologia. 2021 May; 186(2):221-236. doi: 10.1007/s11046-020-00523-z. [PMID: 33550536]
  • Md Moshfekus Saleh-E-In, Ayan Roy, Muhammad Abdullah Al-Mansur, Choudhury Mahmood Hasan, Md Matiur Rahim, Nasim Sultana, Shamim Ahmed, Md Rabiul Islam, Johannes van Staden. Isolation and in silico prediction of potential drug-like compounds from Anethum sowa L. root extracts targeted towards cancer therapy. Computational biology and chemistry. 2019 Feb; 78(?):242-259. doi: 10.1016/j.compbiolchem.2018.11.025. [PMID: 30584950]
  • Olívia Moreira Sampaio, Lucas Campos Curcino Vieira, Barbara Sayuri Bellete, Beatriz King-Diaz, Blas Lotina-Hennsen, Maria Fátima das Graças Fernandes da Silva, Thiago André Moura Veiga. Evaluation of Alkaloids Isolated from Ruta graveolens as Photosynthesis Inhibitors. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102693. [PMID: 30347671]
  • Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero. Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy. Journal of natural products. 2017 10; 80(10):2602-2608. doi: 10.1021/acs.jnatprod.6b01052. [PMID: 29043803]
  • Samrat Ghosh, Kausik Bishayee, Anisur Rahman Khuda-Bukhsh. Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. Phytotherapy research : PTR. 2014 Aug; 28(8):1153-62. doi: 10.1002/ptr.5107. [PMID: 24343999]
  • Amber L Hale, Kumudini M Meepagala, Anna Oliva, Giovanni Aliotta, Stephen O Duke. Phytotoxins from the leaves of Ruta graveolens. Journal of agricultural and food chemistry. 2004 Jun; 52(11):3345-9. doi: 10.1021/jf0497298. [PMID: 15161195]
  • Anna Oliva, Kumudini M Meepagala, David E Wedge, Dewayne Harries, Amber L Hale, Giovanni Aliotta, Stephen O Duke. Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. Journal of agricultural and food chemistry. 2003 Feb; 51(4):890-6. doi: 10.1021/jf0259361. [PMID: 12568545]