Hesperetin 7-neohesperidoside (BioDeep_00000000079)

 

Secondary id: BioDeep_00000400526

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(S)-7-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

化学式: C28H34O15 (610.1897614000001)
中文名称: 新桔皮苷, 新橙皮甙, 新橙皮苷, 柑果苷
谱图信息: 最多检出来源 Viridiplantae(plant) 3.96%

分子结构信息

SMILES: c(O)(c3)c(C(=O)2)c(cc3O[C@H](O5)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)5)O[C@H](O4)[C@H](O)[C@H](O)[C@@H](O)[C@H](C)4)O[C@@H](C2)c(c1)ccc(c1O)OC
InChI: InChI=1/C28H34O15/c1-10-21(33)23(35)25(37)27(39-10)43-26-24(36)22(34)19(9-29)42-28(26)40-12-6-14(31)20-15(32)8-17(41-18(20)7-12)11-3-4-16(38-2)13(30)5-11/h3-7,10,17,19,21-31,33-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1

描述信息

Neohesperidin is a flavanone glycoside that is hesperitin having an 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group. It has a role as an antineoplastic agent and a plant metabolite. It is a neohesperidoside, a disaccharide derivative, a dihydroxyflavanone, a member of 3-hydroxyflavanones, a monomethoxyflavanone, a flavanone glycoside and a member of 4-methoxyflavanones. It is functionally related to a hesperetin.
(S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one is a natural product found in Citrus medica, Arabidopsis thaliana, and other organisms with data available.
Constituent of Seville orange peel (Citrus aurantium) and other Citrus subspecies Very bitter flavouring agent. Hesperetin 7-neohesperidoside is found in many foods, some of which are grapefruit/pummelo hybrid, pummelo, citrus, and grapefruit.
Hesperetin 7-neohesperidoside is found in citrus. Hesperetin 7-neohesperidoside is a constituent of Seville orange peel (Citrus aurantium) and other Citrus species Very bitter flavouring agent
Neohesperidin is a flavonoid compound found in high amounts in citrus fruits with anti-oxidant and anti-inflammatory effects.
Neohesperidin is a flavonoid compound found in high amounts in citrus fruits with anti-oxidant and anti-inflammatory effects.

同义名列表

31 个代谢物同义名

(S)-7-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one; (2S)-7-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one; (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one; 7-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one; 7-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-1-benzopyran-4-one; 4H-1-BENZOPYRAN-4-ONE, 7-((2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-, (2S)-; 4H-1-BENZOPYRAN-4-ONE, 7-((2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-, (S)-; 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-; 4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-; (S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside; FLAVANONE, 3,5,7-TRIHYDROXY-4-METHOXY-, 7-(2-O-.ALPHA.-L-RHAMNOPYRANOSYL-.BETA.-D-GLUCOPYRANOSIDE); (S)-4-Methoxy-3,5,7-trihydroxyflavanone-7-[2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside]; Neohesperidin, United States Pharmacopeia (USP) Reference Standard; 8-HYDROXYQUINOLINE-2-CARBOXALDEHYDE8-QUINOLYLHYDRAZONE; 5-18-05-00219 (Beilstein Handbook Reference); Neohesperidin, analytical standard; Hesperetin 7-O-neohesperidoside; Hesperetin-7-O-neohesperidoside; Hesperetin-7-neohesperidoside; Hesperetin 7-neohesperidoside; ARGKVCXINMKCAZ-UZRWAPQLSA-N; NEOHESPERIDIN [USP-RS]; Neohesperidin, >=90\\%; NEOHESPERIDIN [INCI]; (2S)-NEOHESPERIDIN; UNII-OA5C88H3L0; Neohesperidin; SMP1_000209; OA5C88H3L0



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Adel T Osman, Souty M Z Sharkawi, Mohamed I A Hassan, Amira M Abo-Youssef, Ramadan A M Hemeida. Empagliflozin and neohesperidin protect against methotrexate-induced renal toxicity via suppression of oxidative stress and inflammation in male rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Sep; 155(?):112406. doi: 10.1016/j.fct.2021.112406. [PMID: 34256053]
  • Takashi Tsujimoto, Ryoko Arai, Taichi Yoshitomi, Yutaka Yamamoto, Yoshihiro Ozeki, Takashi Hakamatsuka, Nahoko Uchiyama. UHPLC/MS and NMR-Based Metabolomic Analysis of Dried Water Extract of Citrus-Type Crude Drugs. Chemical & pharmaceutical bulletin. 2021 Aug; 69(8):741-746. doi: 10.1248/cpb.c21-00180. [PMID: 34024880]
  • Naymul Karim, Mohammad Rezaul Islam Shishir, Ahmed K Rashwan, Huihui Ke, Wei Chen. Suppression of palmitic acid-induced hepatic oxidative injury by neohesperidin-loaded pectin-chitosan decorated nanoliposomes. International journal of biological macromolecules. 2021 Jul; 183(?):908-917. doi: 10.1016/j.ijbiomac.2021.05.010. [PMID: 33965489]
  • Yi-Kun Wang, Zi-Meng Zhou, Man-Yun Dai, Xiao-Fang Ma, Xue-Rong Xiao, Shou-Wen Zhang, Hong-Ning Liu, Fei Li. Discovery and validation of quality markers of Fructus Aurantii against acetylcholinesterase using metabolomics and bioactivity assays. Journal of separation science. 2021 Jun; 44(11):2189-2205. doi: 10.1002/jssc.202001190. [PMID: 33784419]
  • Yue-Wen Chang, Wen-Jun Zhu, Wei Gu, Jun Sun, Zhi-Qiang Li, Xiao-En Wei. Neohesperidin promotes the osteogenic differentiation of bone mesenchymal stem cells by activating the Wnt/β-catenin signaling pathway. Journal of orthopaedic surgery and research. 2021 May; 16(1):334. doi: 10.1186/s13018-021-02468-5. [PMID: 34020675]
  • Feng-Xiang Zhang, Yu-Lin-Lan Yuan, Shuang-Shuang Cui, Min Li, Xuan Tan, Zuo-Cheng Qiu, Rui-Man Li. Dissection of the potential pharmacological function of neohesperidin dihydrochalcone - a food additive - by in vivo substances profiling and network pharmacology. Food & function. 2021 May; 12(10):4325-4336. doi: 10.1039/d1fo00104c. [PMID: 33876806]
  • Hui Zheng, Xiao-Ting Zhen, Yan Chen, Si-Chen Zhu, Li-Hong Ye, Si-Wei Yang, Qiu-Yan Wang, Jun Cao. In situ antioxidation-assisted matrix solid-phase dispersion microextraction and discrimination of chiral flavonoids from citrus fruit via ion mobility quadrupole time-of-flight high-resolution mass spectrometry. Food chemistry. 2021 May; 343(?):128422. doi: 10.1016/j.foodchem.2020.128422. [PMID: 33143965]
  • Sainan Li, Chunming Liu, Yuchi Zhang, Dongfang Shi, Rong Tsao. Application of accelerated solvent extraction coupled with online two-dimensional countercurrent chromatography for continuous extraction and separation of bioactive compounds from Citrus limon peel. Journal of separation science. 2020 Oct; 43(19):3793-3805. doi: 10.1002/jssc.202000588. [PMID: 32745365]
  • Jing Zhang, Danni Wang, Xiaoyu Zhang, Jing Yang, Xin Chai, Yuefei Wang. Application of 'spider-web' mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Oct; 77(?):153273. doi: 10.1016/j.phymed.2020.153273. [PMID: 32663710]
  • Gopalsamy Rajiv Gandhi, Alan Bruno Silva Vasconcelos, Ding-Tao Wu, Hua-Bin Li, Poovathumkal James Antony, Hang Li, Fang Geng, Ricardo Queiroz Gurgel, Narendra Narain, Ren-You Gan. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Nutrients. 2020 Sep; 12(10):. doi: 10.3390/nu12102907. [PMID: 32977511]
  • Qianqian Zhang, Fang Feng. The Effects of Different Varieties of Aurantii Fructus Immaturus on the Potential Toxicity of Zhi-Zi-Hou-Po Decoction Based on Spectrum-Toxicity Correlation Analysis. Molecules (Basel, Switzerland). 2019 Nov; 24(23):. doi: 10.3390/molecules24234254. [PMID: 31766682]
  • Chunxia Guo, Hua Zhang, Xin Guan, Zhiqin Zhou. The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan of Saccharomyces Cerevisiae BY4742. Molecules (Basel, Switzerland). 2019 Nov; 24(22):. doi: 10.3390/molecules24224093. [PMID: 31766122]
  • Yanling Gong, Rong Dong, Xiaomeng Gao, Jin Li, Li Jiang, Jiale Zheng, Sunliang Cui, Meidan Ying, Bo Yang, Ji Cao, Qiaojun He. Neohesperidin prevents colorectal tumorigenesis by altering the gut microbiota. Pharmacological research. 2019 10; 148(?):104460. doi: 10.1016/j.phrs.2019.104460. [PMID: 31560944]
  • Yongjing Liu, Hua Zhang, Hongmin Yu, Suhua Guo, Dawei Chen. Deep eutectic solvent as a green solvent for enhanced extraction of narirutin, naringin, hesperidin and neohesperidin from Aurantii Fructus. Phytochemical analysis : PCA. 2019 Mar; 30(2):156-163. doi: 10.1002/pca.2801. [PMID: 30426588]
  • Yang Bai, Yuying Zheng, Wenjing Pang, Wei Peng, Hao Wu, Hongliang Yao, Panlin Li, Wen Deng, Jinle Cheng, Weiwei Su. Identification and Comparison of Constituents of Aurantii Fructus and Aurantii Fructus Immaturus by UFLC-DAD-Triple TOF-MS/MS. Molecules (Basel, Switzerland). 2018 Mar; 23(4):. doi: 10.3390/molecules23040803. [PMID: 29601542]
  • Xia Liu, Fang Luo, Pao Li, Yin She, Wanru Gao. Investigation of the interaction for three Citrus flavonoids and α-amylase by surface plasmon resonance. Food research international (Ottawa, Ont.). 2017 07; 97(?):1-6. doi: 10.1016/j.foodres.2017.03.023. [PMID: 28578029]
  • Tie-Ying Dai, Bo Wang, Sheng-Yun Lin, Jian-Ping Jiang, Li-Qiang Wu, Wen-Bing Qian. Pure total flavonoids from Citrus paradisi Macfad induce leukemia cell apoptosis in vitro. Chinese journal of integrative medicine. 2017 May; 23(5):370-375. doi: 10.1007/s11655-016-2593-z. [PMID: 27465424]
  • Haoshu Wu, Yunxi Liu, Xiaobing Chen, Difeng Zhu, Jian Ma, Youyou Yan, Meimei Si, Xian Li, Chongde Sun, Bo Yang, Qiaojun He, Kunsong Chen. Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α Signaling Axis. Pharmacology. 2017; 100(3-4):115-126. doi: 10.1159/000452492. [PMID: 28554169]
  • Jing-Jing Xu, Rui Yang, Li-Hong Ye, Jun Cao, Wan Cao, Shuai-Shuai Hu, Li-Qing Peng. Application of ionic liquids for elution of bioactive flavonoid glycosides from lime fruit by miniaturized matrix solid-phase dispersion. Food chemistry. 2016 Aug; 204(?):167-175. doi: 10.1016/j.foodchem.2016.02.012. [PMID: 26988490]
  • Sheng Jia, Ying Hu, Wenna Zhang, Xiaoyong Zhao, Yanhong Chen, Chongde Sun, Xian Li, Kunsong Chen. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A(y) mice. Food & function. 2015 Mar; 6(3):878-86. doi: 10.1039/c4fo00993b. [PMID: 25620042]
  • See-Lok Ho, Chung-Yan Poon, Chengyuan Lin, Ting Yan, Daniel Wai-Jing Kwong, Ken Kin-Lam Yung, Man S Wong, Zhaoxiang Bian, Hung-Wing Li. Inhibition of β-amyloid Aggregation By Albiflorin, Aloeemodin And Neohesperidin And Their Neuroprotective Effect On Primary Hippocampal Cells Against β-amyloid Induced Toxicity. Current Alzheimer research. 2015; 12(5):424-33. doi: 10.2174/1567205012666150504144919. [PMID: 25938872]
  • Dalia I Hamdan, Mona F Mahmoud, Michael Wink, Assem M El-Shazly. Effect of hesperidin and neohesperidin from bittersweet orange (Citrus aurantium var. bigaradia) peel on indomethacin-induced peptic ulcers in rats. Environmental toxicology and pharmacology. 2014 May; 37(3):907-15. doi: 10.1016/j.etap.2014.03.006. [PMID: 24691249]
  • Kyung-Chul Shin, Hyun-Koo Nam, Deok-Kun Oh. Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts. Journal of agricultural and food chemistry. 2013 Nov; 61(47):11532-40. doi: 10.1021/jf403332e. [PMID: 24188428]
  • Yujing Sun, Liping Qiao, Yan Shen, Ping Jiang, Jianchu Chen, Xingqian Ye. Phytochemical profile and antioxidant activity of physiological drop of citrus fruits. Journal of food science. 2013 Jan; 78(1):C37-42. doi: 10.1111/j.1750-3841.2012.03002.x. [PMID: 23301602]
  • Priyanka Chaudhary, G K Jayaprakasha, Ron Porat, Bhimanagouda S Patil. Degreening and postharvest storage influences 'Star Ruby' grapefruit (Citrus paradisi Macf.) bioactive compounds. Food chemistry. 2012 Dec; 135(3):1667-75. doi: 10.1016/j.foodchem.2012.05.095. [PMID: 22953908]
  • Jiukai Zhang, Chongde Sun, Youyou Yan, Qingjun Chen, Fenglei Luo, Xiaoyan Zhu, Xian Li, Kunsong Chen. Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells. Food chemistry. 2012 Dec; 135(3):1471-8. doi: 10.1016/j.foodchem.2012.06.004. [PMID: 22953882]
  • Jingze Zhang, Wenyuan Gao, Xiao Hu, Zhen Liu, Changxiao Liu. The influence of compatibility of traditional Chinese medicine on the pharmacokinetic of main components in Fructus aurantii. Journal of ethnopharmacology. 2012 Nov; 144(2):277-83. doi: 10.1016/j.jep.2012.09.009. [PMID: 23000113]
  • Fei Xu, Jia Zang, Daozhen Chen, Ting Zhang, Huiying Zhan, Mudan Lu, Hongxiang Zhuge. Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway. Natural product communications. 2012 Nov; 7(11):1475-8. doi: . [PMID: 23285810]
  • Ram M Uckoo, Guddadarangavvanahally K Jayaprakasha, V M Balasubramaniam, Bhimanagouda S Patil. Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques. Journal of food science. 2012 Sep; 77(9):C921-6. doi: 10.1111/j.1750-3841.2012.02865.x. [PMID: 22957912]
  • Yonathan Asikin, Ikuko Taira, Sayuri Inafuku-Teramoto, Hidekazu Sumi, Hideaki Ohta, Kensaku Takara, Koji Wada. The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines. Journal of agricultural and food chemistry. 2012 Aug; 60(32):7973-80. doi: 10.1021/jf301848s. [PMID: 22804782]
  • Chang-Bum Ahn, Tai-Sun Shin, Hye Kyoung Seo, Jae-Young Je. Phenolic composition and antioxidant effect of aqueous extract of Arisaema cum Bile, the Oriental Herb Medicine, in human fibroblast cells. Immunopharmacology and immunotoxicology. 2012 Aug; 34(4):661-6. doi: 10.3109/08923973.2011.649289. [PMID: 22239430]
  • Adriana C E Graziano, Venera Cardile, Lucia Crascì, Sivia Caggia, Paola Dugo, Francesco Bonina, Annamaria Panico. Protective effects of an extract from Citrus bergamia against inflammatory injury in interferon-γ and histamine exposed human keratinocytes. Life sciences. 2012 Jun; 90(25-26):968-74. doi: 10.1016/j.lfs.2012.04.043. [PMID: 22634580]
  • Lei Zhang, Lin Zhu, Yuefei Wang, Zhenzuo Jiang, Xin Chai, Yan Zhu, Xiumei Gao, Aidi Qi. Characterization and quantification of major constituents of Xue Fu Zhu Yu by UPLC-DAD-MS/MS. Journal of pharmaceutical and biomedical analysis. 2012 Mar; 62(?):203-9. doi: 10.1016/j.jpba.2011.12.026. [PMID: 22264846]
  • Ling Tong, Dandan Zhou, Jun Gao, Yonghong Zhu, He Sun, Kaishun Bi. Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2012 Jan; 58(?):58-64. doi: 10.1016/j.jpba.2011.05.001. [PMID: 22018980]
  • Rong Fan, Xi Huang, Yang Wang, Xiao Chen, Ping Ren, Hui Ji, Ying Xie, Yingjin Zhang, Wei Huang, Xinjian Qiu, Zhaoqian Liu, Honghao Zhou, Lan Fan, Lichen Gao. Ethnopharmacokinetic- and activity-guided isolation of a new antidepressive compound from fructus aurantii found in the traditional chinese medicine chaihu-shugan-san: a new approach and its application. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):607584. doi: 10.1155/2012/607584. [PMID: 22454671]
  • Chung-Hung Shih, Ling-Hung Lin, Hsin-Te Hsu, Kuo-Hsien Wang, Chi-Yin Lai, Chien-Ming Chen, Wun-Chang Ko. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):472897. doi: 10.1155/2012/472897. [PMID: 22454667]
  • Trupti Joshi, Kapil Patil, Michael R Fitzpatrick, Levi D Franklin, Qiuming Yao, Jeffrey R Cook, Zheng Wang, Marc Libault, Laurent Brechenmacher, Babu Valliyodan, Xiaolei Wu, Jianlin Cheng, Gary Stacey, Henry T Nguyen, Dong Xu. Soybean Knowledge Base (SoyKB): a web resource for soybean translational genomics. BMC genomics. 2012; 13 Suppl 1(?):S15. doi: 10.1186/1471-2164-13-s1-s15. [PMID: 22369646]
  • Jiukai Zhang, Xiaoyan Zhu, Fenglei Luo, Chongde Sun, Jianzhen Huang, Xian Li, Kunsong Chen. Separation and purification of neohesperidin from the albedo of Citrus reticulata cv. Suavissima by combination of macroporous resin and high-speed counter-current chromatography. Journal of separation science. 2012 Jan; 35(1):128-36. doi: 10.1002/jssc.201100695. [PMID: 22102373]
  • Anna Pękal, Paulina Dróżdż, Magdalena Biesaga, Krystyna Pyrzynska. Evaluation of the antioxidant properties of fruit and flavoured black teas. European journal of nutrition. 2011 Dec; 50(8):681-8. doi: 10.1007/s00394-011-0179-2. [PMID: 21360165]
  • You-Lan Yang, Hsin-Te Hsu, Kuo-Hsien Wang, Cheng-Ying Han, Chien-Ming Chen, Chi-Ming Chen, Wun-Chang Ko. Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio. Journal of biomedical science. 2011 Nov; 18(?):84. doi: 10.1186/1423-0127-18-84. [PMID: 22074248]
  • Lin-ling Lu, Yan Shu, Da-wei Qian, Shu-lan Su, Jin-ao Duan, Ye-fei Qian, Cai-fu Xue. [Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration]. Yao xue xue bao = Acta pharmaceutica Sinica. 2011 Nov; 46(11):1374-9. doi: NULL. [PMID: 22260033]
  • Noriyuki Nakayama, Katsunori Yamaura, Maki Shimada, Koichi Ueno. Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice. Pharmacognosy research. 2011 Jul; 3(3):155-9. doi: 10.4103/0974-8490.84999. [PMID: 22022162]
  • Dalia Hamdan, Mahmoud Zaki El-Readi, Ahmad Tahrani, Florian Herrmann, Dorothea Kaufmann, Nawal Farrag, Assem El-Shazly, Michael Wink. Secondary metabolites of ponderosa lemon (Citrus pyriformis) and their antioxidant, anti-inflammatory, and cytotoxic activities. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2011 Jul; 66(7-8):385-93. doi: 10.1515/znc-2011-7-810. [PMID: 21950163]
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