Neohesperidin (BioDeep_00000400526)

Main id: BioDeep_00000000079

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(S)-7-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

化学式: C28H34O15 (610.1898)
中文名称: 新橙皮苷, 新桔皮苷, 新橙皮甙, 柑果苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O[C@H]2[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=C2O[C@]([H])(C3C=CC(OC)=C(O)C=3)CC(=O)C2=C(O)C=1
InChI: InChI=1S/C28H34O15/c1-10-21(33)23(35)25(37)27(39-10)43-26-24(36)22(34)19(9-29)42-28(26)40-12-6-14(31)20-15(32)8-17(41-18(20)7-12)11-3-4-16(38-2)13(30)5-11/h3-7,10,17,19,21-31,33-37H,8-9H2,1-2H3/t10-,17+,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1

描述信息

Neohesperidin is a flavanone glycoside that is hesperitin having an 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group. It has a role as an antineoplastic agent and a plant metabolite. It is a neohesperidoside, a disaccharide derivative, a dihydroxyflavanone, a member of 3-hydroxyflavanones, a monomethoxyflavanone, a flavanone glycoside and a member of 4-methoxyflavanones. It is functionally related to a hesperetin.
(S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one is a natural product found in Citrus medica, Arabidopsis thaliana, and other organisms with data available.
A flavanone glycoside that is hesperitin having an 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group.
Neohesperidin is a flavonoid compound found in high amounts in citrus fruits with anti-oxidant and anti-inflammatory effects.
Neohesperidin is a flavonoid compound found in high amounts in citrus fruits with anti-oxidant and anti-inflammatory effects.

同义名列表

28 个代谢物同义名

Neohesperidin; (S)-7-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one; (2S)-7-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one; (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one; 4H-1-BENZOPYRAN-4-ONE, 7-((2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-, (2S)-; 4H-1-BENZOPYRAN-4-ONE, 7-((2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-, (S)-; 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-; 4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-; (S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside; FLAVANONE, 3,5,7-TRIHYDROXY-4-METHOXY-, 7-(2-O-.ALPHA.-L-RHAMNOPYRANOSYL-.BETA.-D-GLUCOPYRANOSIDE); Neohesperidin, United States Pharmacopeia (USP) Reference Standard; 8-HYDROXYQUINOLINE-2-CARBOXALDEHYDE8-QUINOLYLHYDRAZONE; 5-18-05-00219 (Beilstein Handbook Reference); Neohesperidin, analytical standard; Hesperetin 7-O-neohesperidoside; Hesperetin-7-neohesperidoside; ARGKVCXINMKCAZ-UZRWAPQLSA-N; NEOHESPERIDIN [USP-RS]; Neohesperidin, >=90\\%; NEOHESPERIDIN [INCI]; (2S)-NEOHESPERIDIN; UNII-OA5C88H3L0; SMP1_000209; OA5C88H3L0; Hesperetin-7-O-neohesperidoside; Neohesperidin



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

84 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ACE2, BCL2, CASP3, CTNNB1, KEAP1, NFE2L2, PPARG, PTGS2, RUNX2, TYR
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 3 BCL2, HMOX1, PTGS2
Nucleus 9 BCL2, CASP3, CTNNB1, HMOX1, KEAP1, NFE2L2, PPARG, PPARGC1A, RUNX2
cytosol 10 BCL2, CASP3, CTNNB1, HMOX1, KEAP1, LIPE, NFE2L2, PPARG, PPARGC1A, RUNX2
centrosome 2 CTNNB1, NFE2L2
nucleoplasm 8 CASP3, CTNNB1, HMOX1, KEAP1, NFE2L2, PPARG, PPARGC1A, RUNX2
RNA polymerase II transcription regulator complex 2 NFE2L2, PPARG
Cell membrane 4 ACE2, CTNNB1, LIPE, TNF
Cytoplasmic side 1 HMOX1
lamellipodium 1 CTNNB1
Early endosome membrane 1 DKK1
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
cell surface 2 ACE2, TNF
glutamatergic synapse 2 CASP3, CTNNB1
Golgi apparatus 1 NFE2L2
Golgi membrane 1 INS
lysosomal membrane 1 GAA
neuronal cell body 2 CASP3, TNF
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 2 LIPE, NFE2L2
Lysosome 2 GAA, TYR
plasma membrane 6 ACE2, CTNNB1, DKK1, GAA, NFE2L2, TNF
Membrane 6 ACE2, BCL2, CTNNB1, GAA, HMOX1, LIPE
apical plasma membrane 1 ACE2
axon 1 CCK
basolateral plasma membrane 1 CTNNB1
caveola 2 LIPE, PTGS2
extracellular exosome 4 ACE2, BMP3, CTNNB1, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 4 BCL2, HMOX1, KEAP1, PTGS2
extracellular space 8 ACE2, BMP3, CCK, DKK1, HMOX1, IL6, INS, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 4 CTNNB1, HMOX1, PPARG, TYR
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 1 BCL2
protein-containing complex 3 BCL2, CTNNB1, PTGS2
intracellular membrane-bounded organelle 3 GAA, PPARG, TYR
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 ACE2, TYR
Secreted 7 ACE2, BMP3, CCK, DKK1, GAA, IL6, INS
extracellular region 8 ACE2, BMP3, CCK, DKK1, GAA, IL6, INS, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
transcription regulator complex 2 CTNNB1, RUNX2
Cell projection, cilium 1 ACE2
centriolar satellite 1 KEAP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
Wnt signalosome 1 CTNNB1
Melanosome membrane 1 TYR
midbody 1 KEAP1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 ACE2
Membrane raft 2 ACE2, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 1 CTNNB1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Nucleus, PML body 1 PPARGC1A
PML body 1 PPARGC1A
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 1 PTGS2
cilium 1 ACE2
chromatin 4 NFE2L2, PPARG, PPARGC1A, RUNX2
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
brush border membrane 1 ACE2
spindle pole 1 CTNNB1
actin filament 1 KEAP1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
Cul3-RING ubiquitin ligase complex 1 KEAP1
Endomembrane system 1 CTNNB1
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
tertiary granule membrane 1 GAA
Melanosome 1 TYR
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ACE2, IL6, INS, PTGS2
endocytic vesicle membrane 1 ACE2
transport vesicle 1 INS
azurophil granule membrane 1 GAA
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
presynaptic active zone cytoplasmic component 1 CTNNB1
[Isoform 1]: Nucleus 1 PPARGC1A
protein-DNA complex 2 CTNNB1, NFE2L2
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
catenin complex 1 CTNNB1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 KEAP1
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Adel T Osman, Souty M Z Sharkawi, Mohamed I A Hassan, Amira M Abo-Youssef, Ramadan A M Hemeida. Empagliflozin and neohesperidin protect against methotrexate-induced renal toxicity via suppression of oxidative stress and inflammation in male rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Sep; 155(?):112406. doi: 10.1016/j.fct.2021.112406. [PMID: 34256053]
  • Takashi Tsujimoto, Ryoko Arai, Taichi Yoshitomi, Yutaka Yamamoto, Yoshihiro Ozeki, Takashi Hakamatsuka, Nahoko Uchiyama. UHPLC/MS and NMR-Based Metabolomic Analysis of Dried Water Extract of Citrus-Type Crude Drugs. Chemical & pharmaceutical bulletin. 2021 Aug; 69(8):741-746. doi: 10.1248/cpb.c21-00180. [PMID: 34024880]
  • Naymul Karim, Mohammad Rezaul Islam Shishir, Ahmed K Rashwan, Huihui Ke, Wei Chen. Suppression of palmitic acid-induced hepatic oxidative injury by neohesperidin-loaded pectin-chitosan decorated nanoliposomes. International journal of biological macromolecules. 2021 Jul; 183(?):908-917. doi: 10.1016/j.ijbiomac.2021.05.010. [PMID: 33965489]
  • Yi-Kun Wang, Zi-Meng Zhou, Man-Yun Dai, Xiao-Fang Ma, Xue-Rong Xiao, Shou-Wen Zhang, Hong-Ning Liu, Fei Li. Discovery and validation of quality markers of Fructus Aurantii against acetylcholinesterase using metabolomics and bioactivity assays. Journal of separation science. 2021 Jun; 44(11):2189-2205. doi: 10.1002/jssc.202001190. [PMID: 33784419]
  • Yue-Wen Chang, Wen-Jun Zhu, Wei Gu, Jun Sun, Zhi-Qiang Li, Xiao-En Wei. Neohesperidin promotes the osteogenic differentiation of bone mesenchymal stem cells by activating the Wnt/β-catenin signaling pathway. Journal of orthopaedic surgery and research. 2021 May; 16(1):334. doi: 10.1186/s13018-021-02468-5. [PMID: 34020675]
  • Feng-Xiang Zhang, Yu-Lin-Lan Yuan, Shuang-Shuang Cui, Min Li, Xuan Tan, Zuo-Cheng Qiu, Rui-Man Li. Dissection of the potential pharmacological function of neohesperidin dihydrochalcone - a food additive - by in vivo substances profiling and network pharmacology. Food & function. 2021 May; 12(10):4325-4336. doi: 10.1039/d1fo00104c. [PMID: 33876806]
  • Hui Zheng, Xiao-Ting Zhen, Yan Chen, Si-Chen Zhu, Li-Hong Ye, Si-Wei Yang, Qiu-Yan Wang, Jun Cao. In situ antioxidation-assisted matrix solid-phase dispersion microextraction and discrimination of chiral flavonoids from citrus fruit via ion mobility quadrupole time-of-flight high-resolution mass spectrometry. Food chemistry. 2021 May; 343(?):128422. doi: 10.1016/j.foodchem.2020.128422. [PMID: 33143965]
  • Sainan Li, Chunming Liu, Yuchi Zhang, Dongfang Shi, Rong Tsao. Application of accelerated solvent extraction coupled with online two-dimensional countercurrent chromatography for continuous extraction and separation of bioactive compounds from Citrus limon peel. Journal of separation science. 2020 Oct; 43(19):3793-3805. doi: 10.1002/jssc.202000588. [PMID: 32745365]
  • Jing Zhang, Danni Wang, Xiaoyu Zhang, Jing Yang, Xin Chai, Yuefei Wang. Application of 'spider-web' mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Oct; 77(?):153273. doi: 10.1016/j.phymed.2020.153273. [PMID: 32663710]
  • Gopalsamy Rajiv Gandhi, Alan Bruno Silva Vasconcelos, Ding-Tao Wu, Hua-Bin Li, Poovathumkal James Antony, Hang Li, Fang Geng, Ricardo Queiroz Gurgel, Narendra Narain, Ren-You Gan. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Nutrients. 2020 Sep; 12(10):. doi: 10.3390/nu12102907. [PMID: 32977511]
  • Qianqian Zhang, Fang Feng. The Effects of Different Varieties of Aurantii Fructus Immaturus on the Potential Toxicity of Zhi-Zi-Hou-Po Decoction Based on Spectrum-Toxicity Correlation Analysis. Molecules (Basel, Switzerland). 2019 Nov; 24(23):. doi: 10.3390/molecules24234254. [PMID: 31766682]
  • Chunxia Guo, Hua Zhang, Xin Guan, Zhiqin Zhou. The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan of Saccharomyces Cerevisiae BY4742. Molecules (Basel, Switzerland). 2019 Nov; 24(22):. doi: 10.3390/molecules24224093. [PMID: 31766122]
  • Yanling Gong, Rong Dong, Xiaomeng Gao, Jin Li, Li Jiang, Jiale Zheng, Sunliang Cui, Meidan Ying, Bo Yang, Ji Cao, Qiaojun He. Neohesperidin prevents colorectal tumorigenesis by altering the gut microbiota. Pharmacological research. 2019 10; 148(?):104460. doi: 10.1016/j.phrs.2019.104460. [PMID: 31560944]
  • Yongjing Liu, Hua Zhang, Hongmin Yu, Suhua Guo, Dawei Chen. Deep eutectic solvent as a green solvent for enhanced extraction of narirutin, naringin, hesperidin and neohesperidin from Aurantii Fructus. Phytochemical analysis : PCA. 2019 Mar; 30(2):156-163. doi: 10.1002/pca.2801. [PMID: 30426588]
  • Yang Bai, Yuying Zheng, Wenjing Pang, Wei Peng, Hao Wu, Hongliang Yao, Panlin Li, Wen Deng, Jinle Cheng, Weiwei Su. Identification and Comparison of Constituents of Aurantii Fructus and Aurantii Fructus Immaturus by UFLC-DAD-Triple TOF-MS/MS. Molecules (Basel, Switzerland). 2018 Mar; 23(4):. doi: 10.3390/molecules23040803. [PMID: 29601542]
  • Xia Liu, Fang Luo, Pao Li, Yin She, Wanru Gao. Investigation of the interaction for three Citrus flavonoids and α-amylase by surface plasmon resonance. Food research international (Ottawa, Ont.). 2017 07; 97(?):1-6. doi: 10.1016/j.foodres.2017.03.023. [PMID: 28578029]
  • Tie-Ying Dai, Bo Wang, Sheng-Yun Lin, Jian-Ping Jiang, Li-Qiang Wu, Wen-Bing Qian. Pure total flavonoids from Citrus paradisi Macfad induce leukemia cell apoptosis in vitro. Chinese journal of integrative medicine. 2017 May; 23(5):370-375. doi: 10.1007/s11655-016-2593-z. [PMID: 27465424]
  • Haoshu Wu, Yunxi Liu, Xiaobing Chen, Difeng Zhu, Jian Ma, Youyou Yan, Meimei Si, Xian Li, Chongde Sun, Bo Yang, Qiaojun He, Kunsong Chen. Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α Signaling Axis. Pharmacology. 2017; 100(3-4):115-126. doi: 10.1159/000452492. [PMID: 28554169]
  • Jing-Jing Xu, Rui Yang, Li-Hong Ye, Jun Cao, Wan Cao, Shuai-Shuai Hu, Li-Qing Peng. Application of ionic liquids for elution of bioactive flavonoid glycosides from lime fruit by miniaturized matrix solid-phase dispersion. Food chemistry. 2016 Aug; 204(?):167-175. doi: 10.1016/j.foodchem.2016.02.012. [PMID: 26988490]
  • Sheng Jia, Ying Hu, Wenna Zhang, Xiaoyong Zhao, Yanhong Chen, Chongde Sun, Xian Li, Kunsong Chen. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A(y) mice. Food & function. 2015 Mar; 6(3):878-86. doi: 10.1039/c4fo00993b. [PMID: 25620042]
  • See-Lok Ho, Chung-Yan Poon, Chengyuan Lin, Ting Yan, Daniel Wai-Jing Kwong, Ken Kin-Lam Yung, Man S Wong, Zhaoxiang Bian, Hung-Wing Li. Inhibition of β-amyloid Aggregation By Albiflorin, Aloeemodin And Neohesperidin And Their Neuroprotective Effect On Primary Hippocampal Cells Against β-amyloid Induced Toxicity. Current Alzheimer research. 2015; 12(5):424-33. doi: 10.2174/1567205012666150504144919. [PMID: 25938872]
  • Dalia I Hamdan, Mona F Mahmoud, Michael Wink, Assem M El-Shazly. Effect of hesperidin and neohesperidin from bittersweet orange (Citrus aurantium var. bigaradia) peel on indomethacin-induced peptic ulcers in rats. Environmental toxicology and pharmacology. 2014 May; 37(3):907-15. doi: 10.1016/j.etap.2014.03.006. [PMID: 24691249]
  • Kyung-Chul Shin, Hyun-Koo Nam, Deok-Kun Oh. Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts. Journal of agricultural and food chemistry. 2013 Nov; 61(47):11532-40. doi: 10.1021/jf403332e. [PMID: 24188428]
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  • Jiukai Zhang, Chongde Sun, Youyou Yan, Qingjun Chen, Fenglei Luo, Xiaoyan Zhu, Xian Li, Kunsong Chen. Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells. Food chemistry. 2012 Dec; 135(3):1471-8. doi: 10.1016/j.foodchem.2012.06.004. [PMID: 22953882]
  • Jingze Zhang, Wenyuan Gao, Xiao Hu, Zhen Liu, Changxiao Liu. The influence of compatibility of traditional Chinese medicine on the pharmacokinetic of main components in Fructus aurantii. Journal of ethnopharmacology. 2012 Nov; 144(2):277-83. doi: 10.1016/j.jep.2012.09.009. [PMID: 23000113]
  • Fei Xu, Jia Zang, Daozhen Chen, Ting Zhang, Huiying Zhan, Mudan Lu, Hongxiang Zhuge. Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway. Natural product communications. 2012 Nov; 7(11):1475-8. doi: . [PMID: 23285810]
  • Ram M Uckoo, Guddadarangavvanahally K Jayaprakasha, V M Balasubramaniam, Bhimanagouda S Patil. Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques. Journal of food science. 2012 Sep; 77(9):C921-6. doi: 10.1111/j.1750-3841.2012.02865.x. [PMID: 22957912]
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