inositol (BioDeep_00000405218)

Main id: BioDeep_00000003231

Secondary id: BioDeep_00000054926, BioDeep_00000169689

natural product PANOMIX_OTCML-2023


代谢物信息卡片


1,2,3,4,5,6-Cyclohexanehexol

化学式: C6H12O6 (180.0633852)
中文名称: D-(+)-手性肌醇, 1L-手性纤维醇, 青蟹肌醇, 粘质肌醇, 表肌醇, 异肌醇, 肌醇
谱图信息: 最多检出来源 Homo sapiens(blood) 0.07%

分子结构信息

SMILES: C1(C(C(C(C(C1O)O)O)O)O)O
InChI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H

描述信息

C26170 - Protective Agent > C1509 - Neuroprotective Agent
A - Alimentary tract and metabolism > A11 - Vitamins
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
D-chiro-Inositol is an epimer of myo-inositol found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity. D-chiro-Inositol is used clinically for the treatment of polycystic ovary syndrome (PCOS) and diabetes mellitus, which can reduce hyperglycemia and ameliorate insulin resistance[1][2][3].
i-Inositol is a chemical compound related to lipids found in many foods, especially fruits such as cantaloupe and oranges.
i-Inositol is a chemical compound related to lipids found in many foods, especially fruits such as cantaloupe and oranges.
Scyllo-Inositol, an amyloid inhibitor, potentialy inhibits α-synuclein aggregation. Scyllo-Inositol stabilizes a non-fibrillar non-toxic form of amyloid-β peptide (Aβ42) in vitro, reverses cognitive deficits, and reduces synaptic toxicity and lowers amyloid plaques in an Alzheimer's disease mouse model[1].
Scyllo-Inositol, an amyloid inhibitor, potentialy inhibits α-synuclein aggregation. Scyllo-Inositol stabilizes a non-fibrillar non-toxic form of amyloid-β peptide (Aβ42) in vitro, reverses cognitive deficits, and reduces synaptic toxicity and lowers amyloid plaques in an Alzheimer's disease mouse model[1].

同义名列表

16 个代谢物同义名

1,2,3,4,5,6-Cyclohexanehexol; L-(−)-chiro-Inositol; D-(+)-CHIRO-INOSITOL; scyllo-Inositol; allo-Inositol; muco-Inositol; epi-Inositol; inositol; mesoinositol; Inositol-c; scyllo-insitol; myo-Inositol; I-inositol; Myoinositol; D-chiro-Inositol; meso-Inositol



数据库引用编号

70 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(13)

BioCyc(36)

PlantCyc(23)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

185 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Bhoomika Sherkhane, Anil Kumar Kalvala, Vijay Kumar Arruri, Dharmendra Kumar Khatri, Shashi Bala Singh. Renoprotective potential of myo-inositol on diabetic kidney disease: Focus on the role of the PINK1/Parkin pathway and mitophagy receptors. Journal of biochemical and molecular toxicology. 2022 Jun; 36(6):e23032. doi: 10.1002/jbt.23032. [PMID: 35243728]
  • Yingying Zhang, Yinan Jiang, Ziying Wang, Jiayu Wang, Mingzhen Zhu, Hui Yang. Effects of Dietary Resveratrol, Bile Acids, Allicin, Betaine, and Inositol on Recovering the Lipid Metabolism Disorder in the Liver of Rare Minnow Gobiocypris rarus Caused by Bisphenol A. Aquaculture nutrition. 2022; 2022(?):6082343. doi: 10.1155/2022/6082343. [PMID: 36860429]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Shadae R Foster, Lowell L Dilworth, Rory K Thompson, Ruby L Alexander-Lindo, Felix O Omoruyi. Effects of combined inositol hexakisphosphate and inositol supplement on antioxidant activity and metabolic enzymes in the liver of streptozotocin-induced type 2 diabetic rats. Chemico-biological interactions. 2017 Sep; 275(?):108-115. doi: 10.1016/j.cbi.2017.07.024. [PMID: 28757134]
  • Dale L Phelps, Robert M Ward, Rick L Williams, Tracy L Nolen, Kristi L Watterberg, William Oh, Michael Goedecke, Richard A Ehrenkranz, Timothy Fennell, Brenda B Poindexter, C Michael Cotten, Mikko Hallman, Ivan D Frantz, Roger G Faix, Kristin M Zaterka-Baxter, Abhik Das, M Bethany Ball, Conra Backstrom Lacy, Michele C Walsh, Waldemar A Carlo, Pablo J Sánchez, Edward F Bell, Seetha Shankaran, David P Carlton, Patricia R Chess, Rosemary D Higgins. Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants. Pediatric research. 2016 08; 80(2):209-17. doi: 10.1038/pr.2016.97. [PMID: 27074126]
  • Lei Yin, Kevin Shengyang Yu, Kun Lu, Xiaozhong Yu. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. Toxicology in vitro : an international journal published in association with BIBRA. 2016 Apr; 32(?):297-309. doi: 10.1016/j.tiv.2016.01.010. [PMID: 26820058]
  • Wei-Dan Jiang, Yang Liu, Jun Jiang, Pei Wu, Lin Feng, Xiao-Qiu Zhou. Copper exposure induces toxicity to the antioxidant system via the destruction of Nrf2/ARE signaling and caspase-3-regulated DNA damage in fish muscle: amelioration by myo-inositol. Aquatic toxicology (Amsterdam, Netherlands). 2015 Feb; 159(?):245-55. doi: 10.1016/j.aquatox.2014.12.020. [PMID: 25562835]
  • Wei-Dan Jiang, Yang Liu, Kai Hu, Jun Jiang, Shu-Hong Li, Lin Feng, Xiao-Qiu Zhou. Copper exposure induces oxidative injury, disturbs the antioxidant system and changes the Nrf2/ARE (CuZnSOD) signaling in the fish brain: protective effects of myo-inositol. Aquatic toxicology (Amsterdam, Netherlands). 2014 Oct; 155(?):301-13. doi: 10.1016/j.aquatox.2014.07.003. [PMID: 25087001]
  • Bo Zhai, Julie Clark, Taotao Ling, Michele Connelly, Fabricio Medina-Bolivar, Fatima Rivas. Antimalarial evaluation of the chemical constituents of hairy root culture of Bixa orellana L. Molecules (Basel, Switzerland). 2014 Jan; 19(1):756-66. doi: 10.3390/molecules19010756. [PMID: 24406786]
  • Yoko Yamashita, Masaru Yamaoka, Tomohisa Hasunuma, Hitoshi Ashida, Ken-ichi Yoshida. Detection of orally administered inositol stereoisomers in mouse blood plasma and their effects on translocation of glucose transporter 4 in skeletal muscle cells. Journal of agricultural and food chemistry. 2013 May; 61(20):4850-4. doi: 10.1021/jf305322t. [PMID: 23641877]
  • Wei-Dan Jiang, Yang Liu, Jun Jiang, Kai Hu, Shu-Hong Li, Lin Feng, Xiao-Qiu Zhou. In vitro interceptive and reparative effects of myo-inositol against copper-induced oxidative damage and antioxidant system disturbance in primary cultured fish enterocytes. Aquatic toxicology (Amsterdam, Netherlands). 2013 May; 132-133(?):100-10. doi: 10.1016/j.aquatox.2013.02.005. [PMID: 23474319]
  • Hiromi Yoshida, Naoko Yoshida, Isoko Kuriyama, Yuka Tomiyama-Sakamoto, Yoshiyuki Mizushina. Profiles of lipid components, fatty acid distributions of triacylglycerols and phospholipids in Jack beans (Canavalia gladiata DC.). Food chemistry. 2013 Jan; 136(2):807-12. doi: 10.1016/j.foodchem.2012.08.087. [PMID: 23122131]
  • Takahiro Fujimoto, Senji Shirasawa. Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney. International journal of molecular medicine. 2012 Dec; 30(6):1287-93. doi: 10.3892/ijmm.2012.1126. [PMID: 22992961]
  • Yingjun Lv, Lei Dai, Huili Han, Shuxia Zhang. PCV2 induces apoptosis and modulates calcium homeostasis in piglet lymphocytes in vitro. Research in veterinary science. 2012 Dec; 93(3):1525-30. doi: 10.1016/j.rvsc.2012.04.003. [PMID: 22542803]
  • Ying Wang, Hsien-yu Wang. Dvl3 translocates IPMK to the cell membrane in response to Wnt. Cellular signalling. 2012 Dec; 24(12):2389-95. doi: 10.1016/j.cellsig.2012.08.009. [PMID: 22940627]
  • Julieta Caballero, Gilles Frenette, Olivier D'Amours, Clémence Belleannée, Nicolas Lacroix-Pepin, Claude Robert, Robert Sullivan. Bovine sperm raft membrane associated Glioma Pathogenesis-Related 1-like protein 1 (GliPr1L1) is modified during the epididymal transit and is potentially involved in sperm binding to the zona pellucida. Journal of cellular physiology. 2012 Dec; 227(12):3876-86. doi: 10.1002/jcp.24099. [PMID: 22552861]
  • Daniel Bosch, Adolfo Saiardi. Arginine transcriptional response does not require inositol phosphate synthesis. The Journal of biological chemistry. 2012 Nov; 287(45):38347-55. doi: 10.1074/jbc.m112.384255. [PMID: 22992733]
  • Giacomo Zara, Paola Goffrini, Tiziana Lodi, Severino Zara, Ilaria Mannazzu, Marilena Budroni. FLO11 expression and lipid biosynthesis are required for air-liquid biofilm formation in a Saccharomyces cerevisiae flor strain. FEMS yeast research. 2012 Nov; 12(7):864-6. doi: 10.1111/j.1567-1364.2012.00831.x. [PMID: 22805178]
  • Michael Hanscho, David E Ruckerbauer, Neha Chauhan, Harald F Hofbauer, Stefan Krahulec, Bernd Nidetzky, Sepp D Kohlwein, Juergen Zanghellini, Klaus Natter. Nutritional requirements of the BY series of Saccharomyces cerevisiae strains for optimum growth. FEMS yeast research. 2012 Nov; 12(7):796-808. doi: 10.1111/j.1567-1364.2012.00830.x. [PMID: 22780918]
  • Feng-Jie Yuan, Dan-Hua Zhu, Yuan-Yuan Tan, De-Kun Dong, Xu-Jun Fu, Shen-Long Zhu, Bai-Quan Li, Qing-Yao Shu. Identification and characterization of the soybean IPK1 ortholog of a low phytic acid mutant reveals an exon-excluding splice-site mutation. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2012 Nov; 125(7):1413-23. doi: 10.1007/s00122-012-1922-7. [PMID: 22733447]
  • Adebowale Adebiyi, Candice M Thomas-Gatewood, M Dennis Leo, Michael W Kidd, Zachary P Neeb, Jonathan H Jaggar. An elevation in physical coupling of type 1 inositol 1,4,5-trisphosphate (IP3) receptors to transient receptor potential 3 (TRPC3) channels constricts mesenteric arteries in genetic hypertension. Hypertension (Dallas, Tex. : 1979). 2012 Nov; 60(5):1213-9. doi: 10.1161/hypertensionaha.112.198820. [PMID: 23045459]
  • Helena Brauer, Julia Strauss, Wiebke Wegner, Carsten Müller-Tidow, Martin Horstmann, Manfred Jücker. Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling. Cellular signalling. 2012 Nov; 24(11):2095-101. doi: 10.1016/j.cellsig.2012.07.017. [PMID: 22820502]
  • Junzhi Duan, Minghui Zhang, Hongliang Zhang, Haiyan Xiong, Pengli Liu, Jauhar Ali, Jinjie Li, Zichao Li. OsMIOX, a myo-inositol oxygenase gene, improves drought tolerance through scavenging of reactive oxygen species in rice (Oryza sativa L.). Plant science : an international journal of experimental plant biology. 2012 Nov; 196(?):143-51. doi: 10.1016/j.plantsci.2012.08.003. [PMID: 23017909]
  • Soumita Ghosh, Arjun Sengupta, Shobhona Sharma, Haripalsingh M Sonawat. Metabolic fingerprints of serum, brain, and liver are distinct for mice with cerebral and noncerebral malaria: a ¹H NMR spectroscopy-based metabonomic study. Journal of proteome research. 2012 Oct; 11(10):4992-5004. doi: 10.1021/pr300562m. [PMID: 22838963]
  • A Santamaria, D Giordano, F Corrado, B Pintaudi, M L Interdonato, G Di Vieste, A Di Benedetto, R D'Anna. One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome. Climacteric : the journal of the International Menopause Society. 2012 Oct; 15(5):490-5. doi: 10.3109/13697137.2011.631063. [PMID: 22192068]
  • M A Anwar, J Shalhoub, P A Vorkas, C S Lim, E J Want, J K Nicholson, E Holmes, A H Davies. In-vitro identification of distinctive metabolic signatures of intact varicose vein tissue via magic angle spinning nuclear magnetic resonance spectroscopy. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2012 Oct; 44(4):442-50. doi: 10.1016/j.ejvs.2012.05.020. [PMID: 22819098]
  • Nisha Singh, Amy C Halliday, Matthew Knight, Nathan A Lack, Edward Lowe, Grant C Churchill. Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens. Acta crystallographica. Section F, Structural biology and crystallization communications. 2012 Oct; 68(Pt 10):1149-52. doi: 10.1107/s1744309112035191. [PMID: 23027737]
  • Elisabeth A Willer, Roland Malli, Alexander I Bondarenko, Stefan Zahler, Angelika M Vollmar, Wolfgang F Graier, Robert Fürst. The vascular barrier-protecting hawthorn extract WS® 1442 raises endothelial calcium levels by inhibition of SERCA and activation of the IP3 pathway. Journal of molecular and cellular cardiology. 2012 Oct; 53(4):567-77. doi: 10.1016/j.yjmcc.2012.07.002. [PMID: 22814436]
  • Suwen Qi, Xin Ouyang, Linqian Wang, Wujian Peng, Jinli Wen, Yong Dai. A pilot metabolic profiling study in serum of patients with chronic kidney disease based on (1) H-NMR-spectroscopy. Clinical and translational science. 2012 Oct; 5(5):379-85. doi: 10.1111/j.1752-8062.2012.00437.x. [PMID: 23067349]
  • Sarah J Adams, Iraz T Aydin, Julide T Celebi. GAB2--a scaffolding protein in cancer. Molecular cancer research : MCR. 2012 Oct; 10(10):1265-70. doi: 10.1158/1541-7786.mcr-12-0352. [PMID: 22871571]
  • Laurence Carroll, Meg Perumal, Neil Vasdev, Edward Robins, Eric O Aboagye. Radiosynthesis and in vivo tumor uptake of 2-deoxy-2-[(18)F]fluoro-myo-inositol. Bioorganic & medicinal chemistry letters. 2012 Oct; 22(19):6148-50. doi: 10.1016/j.bmcl.2012.08.022. [PMID: 22944120]
  • Isabel Garcia-Perez, Alma Villaseñor, Anisha Wijeyesekera, Joram M Posma, Zhirong Jiang, Jeremiah Stamler, Peter Aronson, Robert Unwin, Coral Barbas, Paul Elliott, Jeremy Nicholson, Elaine Holmes. Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model. Journal of proteome research. 2012 Sep; 11(9):4425-35. doi: 10.1021/pr2012544. [PMID: 22594923]
  • Jamie L Willems, Nicholas H Low. Major carbohydrate, polyol, and oligosaccharide profiles of agave syrup. Application of this data to authenticity analysis. Journal of agricultural and food chemistry. 2012 Sep; 60(35):8745-54. doi: 10.1021/jf3027342. [PMID: 22909406]
  • Sarah Gheuens, Long Ngo, Xiaoen Wang, David C Alsop, Robert E Lenkinski, Igor J Koralnik. Metabolic profile of PML lesions in patients with and without IRIS: an observational study. Neurology. 2012 Sep; 79(10):1041-8. doi: 10.1212/wnl.0b013e318268465b. [PMID: 22914832]
  • Mitzi M Gonzales, Takashi Tarumi, Danielle E Eagan, Hirofumi Tanaka, Miral Vaghasia, Andreana P Haley. Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations. Psychosomatic medicine. 2012 Sep; 74(7):691-8. doi: 10.1097/psy.0b013e31825ff1de. [PMID: 22822230]
  • Joan M Boggs, Godha Rangaraj, Awa Dicko. Effect of phosphorylation of phosphatidylinositol on myelin basic protein-mediated binding of actin filaments to lipid bilayers in vitro. Biochimica et biophysica acta. 2012 Sep; 1818(9):2217-27. doi: 10.1016/j.bbamem.2012.04.006. [PMID: 22538354]
  • Sara De Grazia, Gianfranco Carlomagno, Vittorio Unfer, Pietro Cavalli. Myo-inositol soft gel capsules may prevent the risk of coffee-induced neural tube defects. Expert opinion on drug delivery. 2012 Sep; 9(9):1033-9. doi: 10.1517/17425247.2012.701616. [PMID: 22724555]
  • Mohamed Trebak. STIM/Orai signalling complexes in vascular smooth muscle. The Journal of physiology. 2012 Sep; 590(17):4201-8. doi: 10.1113/jphysiol.2012.233353. [PMID: 22641780]
  • K J Grim, A J Abcejo, A Barnes, V Sathish, D F Smelter, G C Ford, M A Thompson, Y S Prakash, C M Pabelick. Caveolae and propofol effects on airway smooth muscle. British journal of anaesthesia. 2012 Sep; 109(3):444-53. doi: 10.1093/bja/aes130. [PMID: 22542538]
  • Emily P Thi, Neil E Reiner. Phosphatidylinositol 3-kinases and their roles in phagosome maturation. Journal of leukocyte biology. 2012 Sep; 92(3):553-66. doi: 10.1189/jlb.0212053. [PMID: 22569897]
  • Gregory M Rankin, Benjamin J Compton, Karen A Johnston, Colin M Hayman, Gavin F Painter, David S Larsen. Synthesis and mass spectral characterization of mycobacterial phosphatidylinositol and its dimannosides. The Journal of organic chemistry. 2012 Aug; 77(16):6743-59. doi: 10.1021/jo301189y. [PMID: 22845613]
  • K Zyla, M Mika, R Duliński, S Swiatkiewicz, J Koreleski, H Pustkowiak, J Piironen. Effects of inositol, inositol-generating phytase B applied alone, and in combination with 6-phytase A to phosphorus-deficient diets on laying performance, eggshell quality, yolk cholesterol, and fatty acid deposition in laying hens. Poultry science. 2012 Aug; 91(8):1915-27. doi: 10.3382/ps.2012-02198. [PMID: 22802186]
  • Anita Aperia. 2011 Homer Smith Award: To serve and protect: classic and novel roles for Na+, K+ -adenosine triphosphatase. Journal of the American Society of Nephrology : JASN. 2012 Aug; 23(8):1283-90. doi: 10.1681/asn.2012010102. [PMID: 22745476]
  • Robyn D Moir, David A Gross, David L Silver, Ian M Willis. SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR. PLoS genetics. 2012 Aug; 8(8):e1002890. doi: 10.1371/journal.pgen.1002890. [PMID: 22927826]
  • Alisa Boutin, Michael D Allen, Susanne Neumann, Marvin C Gershengorn. Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Aug; 26(8):3473-82. doi: 10.1096/fj.12-207860. [PMID: 22593547]
  • Shatakshi Srivastava, Hema Bisht, O P Sidhu, Ashish Srivastava, P C Singh, R M Pandey, S K Raj, Raja Roy, C S Nautiyal. Changes in the metabolome and histopathology of Amaranthus hypochondriacus L. in response to Ageratum enation virus infection. Phytochemistry. 2012 Aug; 80(?):8-16. doi: 10.1016/j.phytochem.2012.05.007. [PMID: 22683210]
  • J Navarro-Fernández, H Pérez-Sánchez, I Martínez-Martínez, I Meliciani, J A Guerrero, V Vicente, J Corral, W Wenzel. In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. Journal of medicinal chemistry. 2012 Jul; 55(14):6403-12. doi: 10.1021/jm300621j. [PMID: 22742452]
  • Pramote Chumnanpuen, Jie Zhang, Intawat Nookaew, Jens Nielsen. Integrated analysis of transcriptome and lipid profiling reveals the co-influences of inositol-choline and Snf1 in controlling lipid biosynthesis in yeast. Molecular genetics and genomics : MGG. 2012 Jul; 287(7):541-54. doi: 10.1007/s00438-012-0697-5. [PMID: 22622761]
  • Francesco Cerino Badone, Marco Amelotti, Elena Cassani, Roberto Pilu. Study of low phytic acid1-7 (lpa1-7), a new ZmMRP4 mutation in maize. The Journal of heredity. 2012 Jul; 103(4):598-605. doi: 10.1093/jhered/ess014. [PMID: 22563127]
  • Hui Fu, Baoman Li, Leif Hertz, Liang Peng. Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH. Neurochemistry international. 2012 Jul; 61(2):187-94. doi: 10.1016/j.neuint.2012.04.010. [PMID: 22564531]
  • Sridevi Nagaraja, Adam Kapela, Nikolaos M Tsoukias. Intercellular communication in the vascular wall: a modeling perspective. Microcirculation (New York, N.Y. : 1994). 2012 Jul; 19(5):391-402. doi: 10.1111/j.1549-8719.2012.00171.x. [PMID: 22340204]
  • Zhijin Zhang, Juan Wang, Rongxue Zhang, Rongfeng Huang. The ethylene response factor AtERF98 enhances tolerance to salt through the transcriptional activation of ascorbic acid synthesis in Arabidopsis. The Plant journal : for cell and molecular biology. 2012 Jul; 71(2):273-87. doi: 10.1111/j.1365-313x.2012.04996.x. [PMID: 22417285]
  • Eugénie Goupil, Veronica Wisehart, Etienne Khoury, Brandon Zimmerman, Sahar Jaffal, Terence E Hébert, Stéphane A Laporte. Biasing the prostaglandin F2α receptor responses toward EGFR-dependent transactivation of MAPK. Molecular endocrinology (Baltimore, Md.). 2012 Jul; 26(7):1189-202. doi: 10.1210/me.2011-1245. [PMID: 22638073]
  • Stella Blasel, Ulrich Pilatus, Joerg Magerkurth, Maya von Stauffenberg, Dmitri Vronski, Manuel Mueller, Lars Woeckel, Elke Hattingen. Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy. Neuroradiology. 2012 Jul; 54(7):753-64. doi: 10.1007/s00234-011-1001-9. [PMID: 22210349]
  • Jaime H Vera, Lucy J Garvey, Joanna M Allsop, Steve Kaye, Myra O McClure, David Back, Simon D Taylor-Robinson, Alan Winston. Alterations in cerebrospinal fluid chemokines are associated with maraviroc exposure and in vivo metabolites measurable by magnetic resonance spectroscopy. HIV clinical trials. 2012 Jul; 13(4):222-7. doi: 10.1310/hct1304-222. [PMID: 22849963]
  • Zulfiya Orynbayeva, Riju Singhal, Elina A Vitol, Michael G Schrlau, Elizabeth Papazoglou, Gary Friedman, Yury Gogotsi. Physiological validation of cell health upon probing with carbon nanotube endoscope and its benefit for single-cell interrogation. Nanomedicine : nanotechnology, biology, and medicine. 2012 Jul; 8(5):590-8. doi: 10.1016/j.nano.2011.08.008. [PMID: 21889477]
  • Rasmi Rekha Mishra, Jitendra Kumar Chaudhary, Pramod C Rath. Cell cycle arrest and apoptosis by expression of a novel TPIP (TPIP-C2) cDNA encoding a C2-domain in HEK-293 cells. Molecular biology reports. 2012 Jul; 39(7):7389-402. doi: 10.1007/s11033-012-1571-6. [PMID: 22311048]
  • Prashant Kapoor, Vijay Ramakrishnan, S Vincent Rajkumar. Bortezomib combination therapy in multiple myeloma. Seminars in hematology. 2012 Jul; 49(3):228-42. doi: 10.1053/j.seminhematol.2012.04.010. [PMID: 22726546]
  • Franziska Kaplan, Louise A Lewis, Johann Wastian, Andreas Holzinger. Plasmolysis effects and osmotic potential of two phylogenetically distinct alpine strains of Klebsormidium (Streptophyta). Protoplasma. 2012 Jul; 249(3):789-804. doi: 10.1007/s00709-011-0324-z. [PMID: 21979310]
  • Marjan Bemani, Hamzeh Izadi, Kamran Mahdian, Abbas Khani, Mohammad Amin Samih. Study on the physiology of diapause, cold hardiness and supercooling point of overwintering pupae of the pistachio fruit hull borer, Arimania comaroffi. Journal of insect physiology. 2012 Jul; 58(7):897-902. doi: 10.1016/j.jinsphys.2012.04.003. [PMID: 22542495]
  • Raymond D Blind, Miyuki Suzawa, Holly A Ingraham. Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK. Science signaling. 2012 Jun; 5(229):ra44. doi: 10.1126/scisignal.2003111. [PMID: 22715467]
  • David E Hanke, Paroo N Parmar, Samuel E K Caddick, Porntip Green, Charles A Brearley. Synthesis of inositol phosphate ligands of plant hormone-receptor complexes: pathways of inositol hexakisphosphate turnover. The Biochemical journal. 2012 Jun; 444(3):601-9. doi: 10.1042/bj20111811. [PMID: 22429240]
  • Xiaoqun Catherine Zhang, Antonella Piccini, Michael P Myers, Linda Van Aelst, Nicholas K Tonks. Functional analysis of the protein phosphatase activity of PTEN. The Biochemical journal. 2012 Jun; 444(3):457-64. doi: 10.1042/bj20120098. [PMID: 22413754]
  • Mohamed Koubaa, Sarra Mghaieth, Brigitte Thomasset, Albrecht Roscher. Gas chromatography-mass spectrometry analysis of 13C labeling in sugars for metabolic flux analysis. Analytical biochemistry. 2012 Jun; 425(2):183-8. doi: 10.1016/j.ab.2012.03.020. [PMID: 22475504]
  • Carlos Munoz, Mentor Sopjani, Miribane Dërmaku-Sopjani, Ahmad Almilaji, Michael Föller, Florian Lang. Downregulation of the osmolyte transporters SMIT and BGT1 by AMP-activated protein kinase. Biochemical and biophysical research communications. 2012 Jun; 422(3):358-62. doi: 10.1016/j.bbrc.2012.04.092. [PMID: 22554511]
  • Damodaran Narayanan, Adebowale Adebiyi, Jonathan H Jaggar. Inositol trisphosphate receptors in smooth muscle cells. American journal of physiology. Heart and circulatory physiology. 2012 Jun; 302(11):H2190-210. doi: 10.1152/ajpheart.01146.2011. [PMID: 22447942]
  • Yan Wang, Ana P Alonso, Curtis G Wilkerson, Kenneth Keegstra. Deep EST profiling of developing fenugreek endosperm to investigate galactomannan biosynthesis and its regulation. Plant molecular biology. 2012 Jun; 79(3):243-58. doi: 10.1007/s11103-012-9909-y. [PMID: 22527750]
  • Yoshiki Nishimura, Toshiharu Shikanai, Soichi Nakamura, Maki Kawai-Yamada, Hirofumi Uchimiya. Gsp1 triggers the sexual developmental program including inheritance of chloroplast DNA and mitochondrial DNA in Chlamydomonas reinhardtii. The Plant cell. 2012 Jun; 24(6):2401-14. doi: 10.1105/tpc.112.097865. [PMID: 22715041]
  • Hesham A Tawfeek, Abdul B Abou-Samra. Disruption of parathyroid hormone and parathyroid hormone-related peptide receptor phosphorylation prolongs ERK1/2 MAPK activation and enhances c-fos expression. American journal of physiology. Endocrinology and metabolism. 2012 Jun; 302(11):E1363-72. doi: 10.1152/ajpendo.00034.2012. [PMID: 22414806]
  • D Mekahli, E Sammels, T Luyten, K Welkenhuyzen, L P van den Heuvel, E N Levtchenko, R Gijsbers, G Bultynck, J B Parys, H De Smedt, L Missiaen. Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release. Cell calcium. 2012 Jun; 51(6):452-8. doi: 10.1016/j.ceca.2012.03.002. [PMID: 22456092]
  • R Venturella, R Mocciaro, E De Trana, P D'Alessandro, M Morelli, F Zullo. [Assessment of the modification of the clinical, endocrinal and metabolical profile of patients with PCOS syndrome treated with myo-inositol]. Minerva ginecologica. 2012 Jun; 64(3):239-43. doi: ". [PMID: 22635019]
  • Roberto Ciarcia, Maria Teresa Vitiello, Massimiliano Galdiero, Carmen Pacilio, Valentina Iovane, Danila d'Angelo, David Pagnini, Giuseppe Caparrotti, Daniele Conti, Valentina Tomei, Salvatore Florio, Antonio Giordano. Imatinib treatment inhibit IL-6, IL-8, NF-KB and AP-1 production and modulate intracellular calcium in CML patients. Journal of cellular physiology. 2012 Jun; 227(6):2798-803. doi: 10.1002/jcp.23029. [PMID: 21938724]
  • Douglas MacKay, John Hathcock, Erminia Guarneri. Niacin: chemical forms, bioavailability, and health effects. Nutrition reviews. 2012 Jun; 70(6):357-66. doi: 10.1111/j.1753-4887.2012.00479.x. [PMID: 22646128]
  • Adelaide Del Viscovo, Agnese Secondo, Alba Esposito, Fernando Goglia, Maria Moreno, Lorella M T Canzoniero. Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells. American journal of physiology. Endocrinology and metabolism. 2012 Jun; 302(11):E1419-30. doi: 10.1152/ajpendo.00389.2011. [PMID: 22414808]
  • Yuan Wang, Yu-Jia Chu, Hong-Wei Xue. Inositol polyphosphate 5-phosphatase-controlled Ins(1,4,5)P3/Ca2+ is crucial for maintaining pollen dormancy and regulating early germination of pollen. Development (Cambridge, England). 2012 Jun; 139(12):2221-33. doi: 10.1242/dev.081224. [PMID: 22573619]
  • Jasmohan S Bajaj, Patrick M Gillevet, Neeral R Patel, Vishwadeep Ahluwalia, Jason M Ridlon, Birgit Kettenmann, Christine M Schubert, Masoumeh Sikaroodi, Douglas M Heuman, Mary M E Crossey, Debulon E Bell, Philip B Hylemon, Panos P Fatouros, Simon D Taylor-Robinson. A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy. Metabolic brain disease. 2012 Jun; 27(2):205-15. doi: 10.1007/s11011-012-9303-0. [PMID: 22527995]
  • W Bogner, S Gruber, S Trattnig, M Chmelik. High-resolution mapping of human brain metabolites by free induction decay (1)H MRSI at 7 T. NMR in biomedicine. 2012 Jun; 25(6):873-82. doi: 10.1002/nbm.1805. [PMID: 22190245]
  • Mihály Kondrák, Ferenc Marincs, Ferenc Antal, Zsófia Juhász, Zsófia Bánfalvi. Effects of yeast trehalose-6-phosphate synthase 1 on gene expression and carbohydrate contents of potato leaves under drought stress conditions. BMC plant biology. 2012 May; 12(?):74. doi: 10.1186/1471-2229-12-74. [PMID: 22646706]
  • Guillaume Blanc, Irina Agarkova, Jane Grimwood, Alan Kuo, Andrew Brueggeman, David D Dunigan, James Gurnon, Istvan Ladunga, Erika Lindquist, Susan Lucas, Jasmyn Pangilinan, Thomas Pröschold, Asaf Salamov, Jeremy Schmutz, Donald Weeks, Takashi Yamada, Alexandre Lomsadze, Mark Borodovsky, Jean-Michel Claverie, Igor V Grigoriev, James L Van Etten. The genome of the polar eukaryotic microalga Coccomyxa subellipsoidea reveals traits of cold adaptation. Genome biology. 2012 May; 13(5):R39. doi: 10.1186/gb-2012-13-5-r39. [PMID: 22630137]
  • Sonali Sengupta, Sritama Mukherjee, Sabiha Parween, Arun Lahiri Majumder. Galactinol synthase across evolutionary diverse taxa: functional preference for higher plants?. FEBS letters. 2012 May; 586(10):1488-96. doi: 10.1016/j.febslet.2012.04.003. [PMID: 22673515]
  • Sunny D Rupwate, Preeti S Rupwate, Ram Rajasekharan. Regulation of lipid biosynthesis by phosphatidylinositol-specific phospholipase C through the transcriptional repression of upstream activating sequence inositol containing genes. FEBS letters. 2012 May; 586(10):1555-60. doi: 10.1016/j.febslet.2012.04.022. [PMID: 22673525]
  • Guojin Wu, Wei Zhang, Tao Na, Haiyan Jing, Hongju Wu, Ji-Bin Peng. Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease. American journal of physiology. Cell physiology. 2012 May; 302(10):C1479-91. doi: 10.1152/ajpcell.00277.2011. [PMID: 22378746]
  • Tao Sun, Stephanie J Wetzel, Mitchell E Johnson, Beth A Surlow, Jana Patton-Vogt. Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the quantification of lipid-related extracellular metabolites in Saccharomyces cerevisiae. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 May; 897(?):1-9. doi: 10.1016/j.jchromb.2012.03.034. [PMID: 22541168]
  • Khadija Ben-Aissa, Genaro Patino-Lopez, Natalya V Belkina, Ofelia Maniti, Tilman Rosales, Jian-Jiang Hao, Michael J Kruhlak, Jay R Knutson, Catherine Picart, Stephen Shaw. Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an autoinhibitory linker. The Journal of biological chemistry. 2012 May; 287(20):16311-23. doi: 10.1074/jbc.m111.304881. [PMID: 22433855]
  • Margaret R Cunningham, Kathryn A McIntosh, John D Pediani, Joris Robben, Alexandra E Cooke, Mary Nilsson, Gwyn W Gould, Stuart Mundell, Graeme Milligan, Robin Plevin. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4). The Journal of biological chemistry. 2012 May; 287(20):16656-69. doi: 10.1074/jbc.m111.315911. [PMID: 22411985]
  • Christopher K Glass, Jerrold M Olefsky. Inflammation and lipid signaling in the etiology of insulin resistance. Cell metabolism. 2012 May; 15(5):635-45. doi: 10.1016/j.cmet.2012.04.001. [PMID: 22560216]
  • S Gheuens, D R Smith, X Wang, D C Alsop, R E Lenkinski, I J Koralnik. Simultaneous PML-IRIS after discontinuation of natalizumab in a patient with MS. Neurology. 2012 May; 78(18):1390-3. doi: 10.1212/wnl.0b013e318253d61e. [PMID: 22517104]
  • April S Y Wong, Emmie N M Ho, Terence S M Wan. Detection of myo-inositol trispyrophosphate in equine urine and plasma by hydrophillic interaction chromatography-tandem mass spectrometry. Drug testing and analysis. 2012 May; 4(5):355-61. doi: 10.1002/dta.397. [PMID: 22359395]
  • Nguyen Trong Hung, Hironori Yamamoto, Yuichiro Takei, Masashi Masuda, Ayako Otani, Mina Kozai, Shoko Ikeda, Otoki Nakahashi, Sarasa Tanaka, Yutaka Taketani, Eiji Takeda. Up-regulation of stanniocalcin 1 expression by 1,25-dihydroxy vitamin D(3) and parathyroid hormone in renal proximal tubular cells. Journal of clinical biochemistry and nutrition. 2012 May; 50(3):227-33. doi: 10.3164/jcbn.11-99. [PMID: 22573926]
  • Hui-Ling Liao, Jacqueline K Burns. Gene expression in Citrus sinensis fruit tissues harvested from huanglongbing-infected trees: comparison with girdled fruit. Journal of experimental botany. 2012 May; 63(8):3307-19. doi: 10.1093/jxb/ers070. [PMID: 22407645]
  • M Nordio, E Proietti. The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. European review for medical and pharmacological sciences. 2012 May; 16(5):575-81. doi: NULL. [PMID: 22774396]
  • Amador Goodridge, Carla Cueva, Maureen Lahiff, Grace Muzanye, John L Johnson, Payam Nahid, Lee W Riley. Anti-phospholipid antibody levels as biomarker for monitoring tuberculosis treatment response. Tuberculosis (Edinburgh, Scotland). 2012 May; 92(3):243-7. doi: 10.1016/j.tube.2012.02.004. [PMID: 22406155]
  • Jenny Gu, Katrin Weber, Elisabeth Klemp, Gidon Winters, Susanne U Franssen, Isabell Wienpahl, Ann-Kathrin Huylmans, Karsten Zecher, Thorsten B H Reusch, Erich Bornberg-Bauer, Andreas P M Weber. Identifying core features of adaptive metabolic mechanisms for chronic heat stress attenuation contributing to systems robustness. Integrative biology : quantitative biosciences from nano to macro. 2012 May; 4(5):480-93. doi: 10.1039/c2ib00109h. [PMID: 22402787]
  • Khaled Ben El Kadhi, Grégory Emery, Sebastien Carreno. The unexpected role of Drosophila OCRL during cytokinesis. Communicative & integrative biology. 2012 May; 5(3):291-3. doi: 10.4161/cib.19914. [PMID: 22896796]
  • H Plattner, I M Sehring, I K Mohamed, K Miranda, W De Souza, R Billington, A Genazzani, E-M Ladenburger. Calcium signaling in closely related protozoan groups (Alveolata): non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic Apicomplexa (Plasmodium, Toxoplasma). Cell calcium. 2012 May; 51(5):351-82. doi: 10.1016/j.ceca.2012.01.006. [PMID: 22387010]
  • Alexandra Constantin, Adam Elkhaled, Llewellyn Jalbert, Radhika Srinivasan, Soonmee Cha, Susan M Chang, Ruzena Bajcsy, Sarah J Nelson. Identifying malignant transformations in recurrent low grade gliomas using high resolution magic angle spinning spectroscopy. Artificial intelligence in medicine. 2012 May; 55(1):61-70. doi: 10.1016/j.artmed.2012.01.002. [PMID: 22387185]