Thymidine (BioDeep_00000398589)

Main id: BioDeep_00000000073

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Thymidine

化学式: C10H14N2O5 (242.09026740000002)
中文名称: β-胸苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
InChI: InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)

描述信息

relative retention time with respect to 9-anthracene Carboxylic Acid is 0.220
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.211
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.213
Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].
Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].

同义名列表

3 个代谢物同义名

Thymidine; DThyd; NSC 21548



数据库引用编号

48 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(7)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

42 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Naoki Fukui, Takuya Fujiwara, Masakazu Furuta, Satoshi Takatori. [Detection of Gamma-Ray Irradiation History of Dried Plant-Based Foods via the Analysis of 5,6-Dihydrothymidine]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan. 2023; 64(6):206-213. doi: 10.3358/shokueishi.64.206. [PMID: 38171890]
  • Fan Yang, Xiaoqiang Shi, Weidong Yang, Chao Gao, Zhenyu Cui, Wentao Wang. Pueraria montana (Kudzu vine) Ameliorate the Inflammation and Oxidative Stress against Fe-NTA Induced Renal Cancer. Journal of oleo science. 2022 Sep; 71(10):1481-1492. doi: 10.5650/jos.ess22151. [PMID: 36089399]
  • Markus Niehaus, Henryk Straube, André Specht, Chiara Baccolini, Claus-Peter Witte, Marco Herde. The nucleotide metabolome of germinating Arabidopsis thaliana seeds reveals a central role for thymidine phosphorylation in chloroplast development. The Plant cell. 2022 09; 34(10):3790-3813. doi: 10.1093/plcell/koac207. [PMID: 35861422]
  • Mohammed Anowar Hosen, Nasrin Sultana Munia, Mohammed Al-Ghorbani, Mohammed Baashen, Faisal A Almalki, Taibi Ben Hadda, Ferdausi Ali, Shafi Mahmud, Md Abu Saleh, Hamid Laaroussi, Sarkar M A Kawsar. Synthesis, antimicrobial, molecular docking and molecular dynamics studies of lauroyl thymidine analogs against SARS-CoV-2: POM study and identification of the pharmacophore sites. Bioorganic chemistry. 2022 08; 125(?):105850. doi: 10.1016/j.bioorg.2022.105850. [PMID: 35533581]
  • Christine K Iwahashi, Jonathan Kopel, Harrison Marsh, Ted W Reid. Effects of Dexamethasone on DNA Synthesis in Lens Epithelial Cells Are Dependent on Cell Type and Growth Factor. Current eye research. 2022 07; 47(7):1009-1015. doi: 10.1080/02713683.2022.2052106. [PMID: 35260019]
  • Chao Gao, Long Zhang, Enuo Chen, Wenzheng Zhang. Aqp2+ Progenitor Cells Maintain and Repair Distal Renal Segments. Journal of the American Society of Nephrology : JASN. 2022 07; 33(7):1357-1376. doi: 10.1681/asn.2021081105. [PMID: 35318267]
  • Julie Høgh, Malene Hove-Skovsgaard, Marco Gelpi, Anne Marie Reimer Jensen, Jan Gerstoft, Thomas Benfield, Heidi Storgaard, Susanne Dam Nielsen. Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency. BMC infectious diseases. 2022 May; 22(1):503. doi: 10.1186/s12879-022-07485-1. [PMID: 35643429]
  • Dmitry I Maltsev, Kennelia A Mellanson, Vsevolod V Belousov, Grigori N Enikolopov, Oleg V Podgorny. The bioavailability time of commonly used thymidine analogues after intraperitoneal delivery in mice: labeling kinetics in vivo and clearance from blood serum. Histochemistry and cell biology. 2022 Feb; 157(2):239-250. doi: 10.1007/s00418-021-02048-y. [PMID: 34757474]
  • Ayesha Rahman Ahmed, Senty Vun-Sang, Mohammad Iqbal. Therapeutic role of nitroglycerin against copper-nitrilotriacetate induced hepatic and renal damage. Human & experimental toxicology. 2022 Jan; 41(?):9603271221131312. doi: 10.1177/09603271221131312. [PMID: 36305384]
  • Omar D Subedar, Loraine L Y Chiu, Stephen D Waldman. Cell Cycle Synchronization of Primary Articular Chondrocytes Enhances Chondrogenesis. Cartilage. 2021 10; 12(4):526-535. doi: 10.1177/1947603519841677. [PMID: 30971093]
  • Nurjannatul Naim Kamaruddin, Nor Azwin Hajri, Yosie Andriani, Aina Farahiyah Abdul Manan, Tengku Sifzizul Tengku Muhammad, Habsah Mohamad. Acanthaster planci Inhibits PCSK9 and Lowers Cholesterol Levels in Rats. Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26165094. [PMID: 34443682]
  • Jessie W Yester, Honghai Liu, Frank Gyngard, Niyatie Ammanamanchi, Kathryn C Little, Dawn Thomas, Mara L G Sullivan, Sean Lal, Matthew L Steinhauser, Bernhard Kühn. Use of stable isotope-tagged thymidine and multi-isotope imaging mass spectrometry (MIMS) for quantification of human cardiomyocyte division. Nature protocols. 2021 04; 16(4):1995-2022. doi: 10.1038/s41596-020-00477-y. [PMID: 33627842]
  • Antonio Mancini, Francesco Guidi, Carmine Bruno, Flavia Angelini, Edoardo Vergani, Paola Lanza, Alvaro Mordente, Elisabetta Meucci, Andrea Silvestrini. Can plasma antioxidants prevent DNA damage in oxidative stress condition induced by growth hormone deficiency? A pilot study. PloS one. 2021; 16(4):e0248971. doi: 10.1371/journal.pone.0248971. [PMID: 33793606]
  • Leila Darki, Arash Jalali-Sohi, Said R Beydoun. Polyneuropathy Reveals Origins of Decade-long Gastrointestinal Symptoms in a Patient With Undiagnosed Mitochondrial Neurogastrointestinal Encephalopathy Caused by a Novel Mutation. Journal of clinical neuromuscular disease. 2020 Dec; 22(2):97-102. doi: 10.1097/cnd.0000000000000326. [PMID: 33214395]
  • Natsumi Nagano, Yoshiyuki Kawakami, Takehisa Matsumoto, Koichi Tanimoto, Masami Kashihara, Megumi Nagata, Hideyasu Honjyo, Konosuke Yamamoto, Atsuaki Takada, Tetsuro Sugiura. Isolation of thymidine-dependent and extended-spectrum-β-lactamase-producing Escherichia coli small-colony variant from urine of a septuagenarian female patient with recurrent cystitis: A case report with genetic investigation. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2020 Oct; 26(10):1066-1069. doi: 10.1016/j.jiac.2020.05.013. [PMID: 32571646]
  • Brandon J Eudy, Caitlin E McDermott, Gabriel Fernandez, Clayton E Mathews, Jinping Lai, Robin P da Silva. Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice. The Journal of nutritional biochemistry. 2020 07; 81(?):108381. doi: 10.1016/j.jnutbio.2020.108381. [PMID: 32422424]
  • Cancan Yang, Jing Li, Zhenling Huang, Xuefa Zhang, Xiaolei Gao, Chunyuang Zhu, Paul F Morris, XiuGuo Zhang. Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici. Scientific reports. 2020 06; 10(1):9051. doi: 10.1038/s41598-020-65935-9. [PMID: 32493959]
  • KimberlyA Kripps, Warapan Nakayuenyongsuk, Brian J Shayota, William Berquist, Natalia Gomez-Ospina, Carlos O Esquivel, Waldo Concepcion, Jacinda B Sampson, David J Cristin, Whitney E Jackson, Samuel Gilliland, Elizabeth A Pomfret, Michael L Kueht, Rowland W Pettit, Youmna A Sherif, Lisa T Emrick, Sarah H Elsea, Ryan Himes, Michio Hirano, Johan L K Van Hove, Fernando Scaglia, Gregory M Enns, Austin A Larson. Successful liver transplantation in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Molecular genetics and metabolism. 2020 05; 130(1):58-64. doi: 10.1016/j.ymgme.2020.03.001. [PMID: 32173240]
  • Wei Guo, Xia Wu, Yi Li, Jixue Gao, Feng Wang, Yongsheng Jin, Tie Chong, Anshoo Malhotra. Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer. Journal of drug targeting. 2020 01; 28(1):41-45. doi: 10.1080/1061186x.2019.1601199. [PMID: 30943812]
  • Fanglin Ming, Jingzhou Hou, Changjun Hou, Mei Yang, Xianfeng Wang, Jiawei Li, Danqun Huo, Qiang He. One-step synthesized fluorescent nitrogen doped carbon dots from thymidine for Cr (VI) detection in water. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 Nov; 222(?):117165. doi: 10.1016/j.saa.2019.117165. [PMID: 31185440]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Marco Gelpi, Andreas Dehlbæk Knudsen, Karoline Brostrup Larsen, Amanda Mocroft, Anne-Mette Lebech, Birgitte Lindegaard, Jens Lundgren, Klaus Fuglsang Kofoed, Susanne Dam Nielsen. Long-lasting alterations in adipose tissue density and adiponectin production in people living with HIV after thymidine analogues exposure. BMC infectious diseases. 2019 Aug; 19(1):708. doi: 10.1186/s12879-019-4347-y. [PMID: 31399063]
  • Christelle Guillermier, Sean P Doherty, Adam G Whitney, Vladimir R Babaev, MacRae F Linton, Matthew L Steinhauser, Jonathan D Brown. Imaging mass spectrometry reveals heterogeneity of proliferation and metabolism in atherosclerosis. JCI insight. 2019 06; 4(11):. doi: 10.1172/jci.insight.128528. [PMID: 31167964]
  • A V Kara, Y Yıldırım, F Ozcicek, M N Aldemir, Y Arslan, K Bayan, M K Çelen. Effects of entecavir, tenofovir and telbivudine treatment on renal functions in chronic hepatitis B patients. Acta gastro-enterologica Belgica. 2019 Apr; 82(2):273-277. doi: . [PMID: 31314188]
  • Yi Ning, Jue Hu, Ke Wei, Guliang He, Tao Wu, Fangguo Lu. Fluorometric determination of mercury(II) via a graphene oxide-based assay using exonuclease III-assisted signal amplification and thymidine-Hg(II)-thymidine interaction. Mikrochimica acta. 2019 03; 186(4):216. doi: 10.1007/s00604-019-3332-x. [PMID: 30838468]
  • José-Antonio Pedroza-García, Manuela Nájera-Martínez, Christelle Mazubert, Paulina Aguilera-Alvarado, Jeannine Drouin-Wahbi, Sobeida Sánchez-Nieto, José M Gualberto, Cécile Raynaud, Javier Plasencia. Role of pyrimidine salvage pathway in the maintenance of organellar and nuclear genome integrity. The Plant journal : for cell and molecular biology. 2019 02; 97(3):430-446. doi: 10.1111/tpj.14128. [PMID: 30317699]
  • Ravi Patel, Lucia Lee Coulter, Joanna Rimmer, Miles Parkes, Patrick Francis Chinnery, Oscar Swift. Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn's disease. BMC gastroenterology. 2019 Jan; 19(1):11. doi: 10.1186/s12876-018-0925-5. [PMID: 30646848]
  • Toshinori Suzuki, Masashi Kumagai, Masahiro Furusawa. Effects of Urea on the Reactions of Nucleosides with Hypobromous Acid. Chemical & pharmaceutical bulletin. 2019; 67(7):707-712. doi: 10.1248/cpb.c18-01009. [PMID: 31257326]
  • Xiangzhong Zhao, Jingru Lu, Yanxia Gao, Xiaoling Wang, Yanhua Lang, Leping Shao. Novel compound heterozygous ATP6V1B1 mutations in a Chinese child patient with primary distal renal tubular acidosis: a case report. BMC nephrology. 2018 12; 19(1):364. doi: 10.1186/s12882-018-1173-1. [PMID: 30558562]
  • Zhaoping Yan, Bing Qiao, Haifeng Zhang, Yanling Wang, Wei Gou. Effectiveness of telbivudine antiviral treatment in patients with hepatitis B virus-associated glomerulonephritis: A 104-week pilot study. Medicine. 2018 Aug; 97(31):e11716. doi: 10.1097/md.0000000000011716. [PMID: 30075577]
  • Xianghua Guo, Jushan Wu, Feili Wei, Yabo Ouyang, Qing Li, Kai Liu, Yanjun Wang, Yulin Zhang, Dexi Chen. Trends in hepatitis B virus resistance to nucleoside/nucleotide analogues in North China from 2009-2016: A retrospective study. International journal of antimicrobial agents. 2018 Aug; 52(2):201-209. doi: 10.1016/j.ijantimicag.2018.04.002. [PMID: 29654894]
  • Haw-En Wang, Chih-Lang Lin, Tai-Long Pan, Chau-Ting Yeh. Increase of Serum Kallikrein-8 Level After Long-term Telbivudine Treatment. In vivo (Athens, Greece). 2018 Jul; 32(4):955-960. doi: 10.21873/invivo.11334. [PMID: 29936485]
  • Qiu-Ju Sheng, Sui-Jing Wang, Yu-Yu Wu, Xiao-Guang Dou, Yang Ding. Hepatitis B virus serosurvey and awareness of mother-to-child transmission among pregnant women in Shenyang, China: An observational study. Medicine. 2018 Jun; 97(22):e10931. doi: 10.1097/md.0000000000010931. [PMID: 29851831]
  • Alejandro A Edera, Carolina L Gandini, M Virginia Sanchez-Puerta. Towards a comprehensive picture of C-to-U RNA editing sites in angiosperm mitochondria. Plant molecular biology. 2018 Jun; 97(3):215-231. doi: 10.1007/s11103-018-0734-9. [PMID: 29761268]
  • Yue Ying, Yue-Kai Hu, Jia-Lin Jin, Ji-Ming Zhang, Wen-Hong Zhang, Yu-Xian Huang. Case report: lactic acidosis and rhabdomyolysis during telbivudine and tenofovir treatment for chronic hepatitis B. BMC gastroenterology. 2018 Apr; 18(1):45. doi: 10.1186/s12876-018-0773-3. [PMID: 29625557]
  • Bicui Chen, Li Chen, Cai Cheng, Mingkang Zhong, Xiaojin Shi, Jiming Zhang, Bin Wang. Determination of telbivudine in the plasma of chronic hepatitis B patients in long-term treatment by high-performance liquid chromatographic-tandem mass spectrometry. Biomedical chromatography : BMC. 2018 Apr; 32(4):. doi: 10.1002/bmc.4140. [PMID: 29148589]
  • Jie Chen, Detian Li. Telbivudine attenuates UUO-induced renal fibrosis via TGF-β/Smad and NF-κB signaling. International immunopharmacology. 2018 Feb; 55(?):1-8. doi: 10.1016/j.intimp.2017.11.043. [PMID: 29207359]
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  • I F Usynin, A N Dudarev, A Yu Gorodetskaya, S M Miroshnichenko, T A Tkachenko, V I Tkachenko. Apolipoprotein A-I Stimulates Cell Proliferation in Bone Marrow Cell Culture. Bulletin of experimental biology and medicine. 2018 Jan; 164(3):308-311. doi: 10.1007/s10517-018-3978-0. [PMID: 29313227]
  • Michelle Levene, Francisco J Enguita, Bridget E Bax. Discovery profiling and bioinformatics analysis of serum microRNA in Mitochondrial NeuroGastroIntestinal Encephalomyopathy (MNGIE). Nucleosides, nucleotides & nucleic acids. 2018; 37(11):618-629. doi: 10.1080/15257770.2018.1492138. [PMID: 30587073]
  • Long Jianfei, Wang Min, Ma Chunlai, Chen Bicui, Zhang Jiming, Wang Bin. The Ca2+/CaMKK2 axis mediates the telbivudine induced upregulation of creatine kinase: Implications for mechanism of antiviral nucleoside analogs' side effect. Biochemical pharmacology. 2017 12; 146(?):224-232. doi: 10.1016/j.bcp.2017.10.005. [PMID: 29038020]
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  • Hong Shi, Zongping Han, Jian Liu, Jinfang Xue, Shuya Zhang, Zhe Zhu, Jinyu Xia, Mingxing Huang. Comparing Efficacy of Lamivudine, Adefovir Dipivoxil, Telbivudine, and Entecavir in Treating Nucleoside Analogues Naïve for HBeAg-Negative Hepatitis B with Medium Hepatitis B Virus (HBV) DNA Levels. Medical science monitor : international medical journal of experimental and clinical research. 2017 Nov; 23(?):5230-5236. doi: 10.12659/msm.903382. [PMID: 29095799]
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  • Wei-Chen Lee, Tsung-Han Wu, Yu-Chao Wang, Chih-Hsien Cheng, Chen-Fang Lee, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan, Ching-Song Lee. Renal Function Improvement by Telbivudine in Liver Transplant Recipients with Chronic Kidney Disease. BioMed research international. 2017; 2017(?):9324310. doi: 10.1155/2017/9324310. [PMID: 28884132]
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