Pinocembrin (BioDeep_00000396460)

Main id: BioDeep_00000000144

 

natural product PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (S)-(-)-

化学式: C15H12O4 (256.0735552)
中文名称: 乔松素, 分析对照品, 吡菌素
谱图信息: 最多检出来源 Viridiplantae(plant) 15.63%

分子结构信息

SMILES: C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=CC=C3
InChI: InChI=1S/C15H12O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-7,13,16-17H,8H2

描述信息

(2s)-pinocembrin, also known as 5,7-dihydroxyflavanone or dihydrochrysin, is a member of the class of compounds known as flavanones. Flavanones are compounds containing a flavan-3-one moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a ketone at the carbon C3. Thus, (2s)-pinocembrin is considered to be a flavonoid lipid molecule (2s)-pinocembrin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). (2s)-pinocembrin can be found in a number of food items such as acorn, lentils, mulberry, and sorghum, which makes (2s)-pinocembrin a potential biomarker for the consumption of these food products.
(s)-pinocembrin, also known as 5,7-dihydroxyflavanone or dihydrochrysin, is a member of the class of compounds known as flavanones. Flavanones are compounds containing a flavan-3-one moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a ketone at the carbon C3 (s)-pinocembrin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). (s)-pinocembrin is a bitter tasting compound found in mexican oregano and tarragon, which makes (s)-pinocembrin a potential biomarker for the consumption of these food products.
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.069
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.067
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.071
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.070
5,7-Dihydroxyflavanone is a natural product found in Pinus contorta var. latifolia, Piper nigrum, and other organisms with data available.
(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line[1].
(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line[1].
Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1].
Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1].

同义名列表

63 个代谢物同义名

(2S)-pinocembrin; Pinocembrin; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (S)-(-)-; (S)-2,3-Dihydro-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one; (2S)-5,7-dihydroxy-2-phenyl-chroman-4-one; (2S)-5,7-dihydroxy-2-phenyl-4-chromanone; (2S)-5,7-dihydroxy-2-phenylchroman-4-one; 5,7-dihydroxyflavanone; SDCCGMLS-0066749.P001; Pinocembrin (6CI); Spectrum3_001635; Spectrum2_001670; Spectrum4_001765; Spectrum5_000349; Spectrum_001879; SpecPlus_000896; KBioSS_002406; KBioGR_002249; BSPBio_003329; Oprea1_508274; DivK1c_006992; KBio2_007537; KBio1_001936; KBio2_004969; KBio2_002401; ZINC00073693; KBio3_002549; SPBio_001859; AIDS-014893; NSC 661207; NSC 279005; AIDS014893; NSC 43318; ST023293; 480-39-7; C09827; pinocembrine; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (-)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (S)-; 4H-1-Benzopyran-4-one,3-dihydro-5,7-dihydroxy-2-phenyl-, (S)-; 4H-1-Benzopyran-4-one,3-dihydro-5,7-dihydroxy-2-phenyl-, (-)-; 5,7-Dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one #; 5,7-dihydroxy-2-phenyl-2,3-dihydrochromen-4-one; ( inverted exclamation markA)-Pinocembrin; (+/-)-5,7-Dihydroxyflavanone; NSC 43318; 5,7-Dihydroxy-2-phenyl-chroman-4-one; ()-5,7-Dihydroxyflavanone; NSC 43318; 5,7-dihydroxy-2-phenylchroman-4-one; 5,7-dihydroxy-flavanone; Pinocembrin (racemic); PTP inhibitor, 4l; (+/-)-pinocembrin; (+)-pinocoembrin; (±)-Pinocembrin; (s)-pinocembrin; rac-Pinocembrin; ()-Pinocembrin; MEGxp0_000456; ACon1_000231; (±)-5,7-Dihydroxyflavanone; Dihydrochrysin; Galangin flavanone; Pinocembrin



数据库引用编号

43 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(3)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

376 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huixin Tan, Fenghe Wang, Jiahuan Hu, Xiaoyan Duan, Wanting Bai, Xinbo Wang, Baolian Wang, Yan Su, Jinping Hu. Inhibitory interaction of flavonoids with organic cation transporter 2 and their structure-activity relationships for predicting nephroprotective effects. Journal of applied toxicology : JAT. 2023 Apr; ?(?):. doi: 10.1002/jat.4474. [PMID: 37057715]
  • Tingting Ma, Hao Zhang, Tongxi Li, Junjie Bai, Ziming Wu, Tianying Cai, Yifan Chen, Xianming Xia, Yichao Du, Wenguang Fu. Protective effect of pinocembrin from Penthorum chinense Pursh on hepatic ischemia reperfusion injury via regulating HMGB1/TLR4 signal pathway. Phytotherapy research : PTR. 2023 Jan; 37(1):181-194. doi: 10.1002/ptr.7605. [PMID: 36097366]
  • Tong Wang, Hua Tian, Tianqi Pan, Shutong Yao, Huayun Yu, Yumei Wu, Shijun Wang. Pinocembrin suppresses oxidized low-density lipoprotein-triggered NLRP3 inflammasome/GSDMD-mediated endothelial cell pyroptosis through an Nrf2-dependent signaling pathway. Scientific reports. 2022 08; 12(1):13885. doi: 10.1038/s41598-022-18297-3. [PMID: 35974041]
  • Baorui Xing, Nana Feng, Juan Zhang, Yunmei Li, Xiuxiu Hou, Hao Wu, Wendong Liu, Guangpu Han. Pinocembrin relieves hip fracture-induced pain by repressing spinal substance P signaling in aged rats. Journal of neurophysiology. 2022 02; 127(2):397-404. doi: 10.1152/jn.00517.2021. [PMID: 34986062]
  • Hongxia Gong. Pinocembrin suppresses proliferation and enhances apoptosis in lung cancer cells in vitro by restraining autophagy. Bioengineered. 2021 12; 12(1):6035-6044. doi: 10.1080/21655979.2021.1972779. [PMID: 34486470]
  • Ling-Lei Kong, Li Gao, Ke-Xin Wang, Nan-Nan Liu, Cheng-di Liu, Guo-Dong Ma, Hai-Guang Yang, Xue-Mei Qin, Guan-Hua Du. Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites. Acta pharmacologica Sinica. 2021 Aug; 42(8):1223-1234. doi: 10.1038/s41401-021-00664-x. [PMID: 33859344]
  • Halil Ibrahim Guler, Gizem Tatar, Oktay Yildiz, Ali Osman Belduz, Sevgi Kolayli. Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study. Archives of microbiology. 2021 Aug; 203(6):3557-3564. doi: 10.1007/s00203-021-02351-1. [PMID: 33950349]
  • Anna R Cappello, Francesca Aiello, Nicoletta Polerà, Biagio Armentano, Ivan Casaburi, Maria Luisa Di Gioia, Monica R Loizzo, Vincenza Dolce, Vincenzo Pezzi, Rosa Tundis. In vitro anti-proliferative and anti-bacterial properties of new C7 benzoate derivatives of pinocembrin. Natural product research. 2021 Jun; 35(11):1783-1791. doi: 10.1080/14786419.2019.1641805. [PMID: 31311327]
  • Wenqi Wang, Xin Feng, Yu Du, Cen Liu, Xinxin Pang, Kunxiu Jiang, Xirui Wang, Yonggang Liu. Synthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO. Drug design, development and therapy. 2021; 15(?):4177-4193. doi: 10.2147/dddt.s330223. [PMID: 34675482]
  • Jamras Kanchanapiboon, Ubonphan Kongsa, Duangpen Pattamadilok, Sunisa Kamponchaidet, Detmontree Wachisunthon, Subhadhcha Poonsatha, Sasiwan Tuntoaw. Boesenbergia rotunda extract inhibits Candida albicans biofilm formation by pinostrobin and pinocembrin. Journal of ethnopharmacology. 2020 Oct; 261(?):113193. doi: 10.1016/j.jep.2020.113193. [PMID: 32730867]
  • Siwaporn Boonyasuppayakorn, Thanaphon Saelee, Peerapat Visitchanakun, Asada Leelahavanichkul, Kowit Hengphasatporn, Yasuteru Shigeta, Thao Nguyen Thanh Huynh, Justin Jang Hann Chu, Thanyada Rungrotmongkol, Warinthorn Chavasiri. Dibromopinocembrin and Dibromopinostrobin Are Potential Anti-Dengue Leads with Mild Animal Toxicity. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184154. [PMID: 32932762]
  • Bei Yue, Junyu Ren, Zhilun Yu, Xiaoping Luo, Yijing Ren, Jing Zhang, Sridhar Mani, Zhengtao Wang, Wei Dou. Pinocembrin alleviates ulcerative colitis in mice via regulating gut microbiota, suppressing TLR4/MD2/NF-κB pathway and promoting intestinal barrier. Bioscience reports. 2020 07; 40(7):. doi: 10.1042/bsr20200986. [PMID: 32687156]
  • Ramiro Quintanilla-Licea, Javier Vargas-Villarreal, María Julia Verde-Star, Verónica Mayela Rivas-Galindo, Ángel David Torres-Hernández. Antiprotozoal Activity against Entamoeba histolytica of Flavonoids Isolated from Lippia graveolens Kunth. Molecules (Basel, Switzerland). 2020 May; 25(11):. doi: 10.3390/molecules25112464. [PMID: 32466359]
  • Alvaro José Hernández Tasco, Román Yesid Ramírez Rueda, Carlos José Alvarez, Fabiana Terezinha Sartori, Ana Claudia B C Sacilotto, Izabel Yoko Ito, Walter Vichnewski, Marcos José Salvador. Antibacterial and antifungal properties of crude extracts and isolated compounds from Lychnophora markgravii. Natural product research. 2020 Mar; 34(6):863-867. doi: 10.1080/14786419.2018.1503263. [PMID: 30445853]
  • Gasper Maeda, Joan J E Munissi, Sofia Lindblad, Sandra Duffy, Jerry Pelletier, Vicky M Avery, Stephen S Nyandoro, Máté Erdélyi. A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis. Journal of natural products. 2020 02; 83(2):316-322. doi: 10.1021/acs.jnatprod.9b00721. [PMID: 32067457]
  • Tianxin Ye, Cui Zhang, Gang Wu, Weiguo Wan, Jinjun Liang, Xin Liu, Dishiwen Liu, Bo Yang. Pinocembrin attenuates autonomic dysfunction and atrial fibrillation susceptibility via inhibition of the NF-κB/TNF-α pathway in a rat model of myocardial infarction. International immunopharmacology. 2019 Dec; 77(?):105926. doi: 10.1016/j.intimp.2019.105926. [PMID: 31704291]
  • Sarvinoz I Rustamova, Nargiza A Tsiferova, Ozoda J Khamidova, Ranokhon Sh Kurbannazarova, Petr G Merzlyak, Zainab A Khushbaktova, Vladimir N Syrov, Erkin Kh Botirov, Kamila A Eshbakova, Ravshan Z Sabirov. Effect of plant flavonoids on the volume regulation of rat thymocytes under hypoosmotic stress. Pharmacological reports : PR. 2019 Dec; 71(6):1079-1087. doi: 10.1016/j.pharep.2019.05.023. [PMID: 31629088]
  • Jun Gao, Shixin Lin, Yao Gao, Xia Zou, Jun Zhu, Man Chen, Hong Wan, Hong Zhu. Pinocembrin inhibits the proliferation and migration and promotes the apoptosis of ovarian cancer cells through down-regulating the mRNA levels of N-cadherin and GABAB receptor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Dec; 120(?):109505. doi: 10.1016/j.biopha.2019.109505. [PMID: 31634778]
  • Jia Le Lee, Marcus Wing Choy Loe, Regina Ching Hua Lee, Justin Jang Hann Chu. Antiviral activity of pinocembrin against Zika virus replication. Antiviral research. 2019 07; 167(?):13-24. doi: 10.1016/j.antiviral.2019.04.003. [PMID: 30959074]
  • Xiaoling Shen, Yeju Liu, Xiaoya Luo, Zhihong Yang. Advances in Biosynthesis, Pharmacology, and Pharmacokinetics of Pinocembrin, a Promising Natural Small-Molecule Drug. Molecules (Basel, Switzerland). 2019 Jun; 24(12):. doi: 10.3390/molecules24122323. [PMID: 31238565]
  • Pornphimol Meesakul, Christopher Richardson, Stephen G Pyne, Surat Laphookhieo. α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis. Journal of natural products. 2019 04; 82(4):741-747. doi: 10.1021/acs.jnatprod.8b00581. [PMID: 30835120]
  • Kumju Youn, Mira Jun. Biological Evaluation and Docking Analysis of Potent BACE1 Inhibitors from Boesenbergia rotunda. Nutrients. 2019 Mar; 11(3):. doi: 10.3390/nu11030662. [PMID: 30893825]
  • Loretta Pobłocka-Olech, Iwona Inkielewicz-Stepniak, Mirosława Krauze-Baranowska. Anti-inflammatory and antioxidative effects of the buds from different species of Populus in human gingival fibroblast cells: Role of bioflavanones. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Mar; 56(?):1-9. doi: 10.1016/j.phymed.2018.08.015. [PMID: 30668329]
  • Yoshiharu Okuno, Shinsuke Marumoto, Mitsuo Miyazawa. Antimutagenic activity of flavonoids from Sozuku. Natural product research. 2019 Mar; 33(6):862-865. doi: 10.1080/14786419.2017.1408104. [PMID: 29183163]
  • R Tundis, L Frattaruolo, G Carullo, B Armentano, M Badolato, M R Loizzo, F Aiello, A R Cappello. An ancient remedial repurposing: synthesis of new pinocembrin fatty acid acyl derivatives as potential antimicrobial/anti-inflammatory agents. Natural product research. 2019 Jan; 33(2):162-168. doi: 10.1080/14786419.2018.1440224. [PMID: 29463111]
  • Yannan Li, Jing Ning, Yan Wang, Chao Wang, Chengpeng Sun, Xiaokui Huo, Zhenlong Yu, Lei Feng, Baojing Zhang, Xiangge Tian, Xiaochi Ma. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicology letters. 2018 Sep; 294(?):27-36. doi: 10.1016/j.toxlet.2018.05.008. [PMID: 29753067]
  • Peng Zhang, Jin Xu, Wei Hu, Dong Yu, Xiaolu Bai. Effects of Pinocembrin Pretreatment on Connexin 43 (Cx43) Protein Expression After Rat Myocardial Ischemia-Reperfusion and Cardiac Arrhythmia. Medical science monitor : international medical journal of experimental and clinical research. 2018 Jul; 24(?):5008-5014. doi: 10.12659/msm.909162. [PMID: 30022020]
  • Piotr Kuś, Igor Jerković, Martina Jakovljević, Stela Jokić. Extraction of bioactive phenolics from black poplar (Populus nigra L.) buds by supercritical CO2 and its optimization by response surface methodology. Journal of pharmaceutical and biomedical analysis. 2018 Apr; 152(?):128-136. doi: 10.1016/j.jpba.2018.01.046. [PMID: 29414004]
  • Jessica Granados-Pineda, Norma Uribe-Uribe, Patricia García-López, María Del Pilar Ramos-Godinez, J Fausto Rivero-Cruz, Jazmin Marlen Pérez-Rojas. Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy. Molecules (Basel, Switzerland). 2018 Apr; 23(4):. doi: 10.3390/molecules23040852. [PMID: 29642511]
  • Isabel Escriche, Marisol Juan-Borrás. Standardizing the analysis of phenolic profile in propolis. Food research international (Ottawa, Ont.). 2018 04; 106(?):834-841. doi: 10.1016/j.foodres.2018.01.055. [PMID: 29579994]
  • Marwa M Said, Samar S Azab, Noha M Saeed, Ebtehal El-Demerdash. Antifibrotic Mechanism of Pinocembrin: Impact on Oxidative Stress, Inflammation and TGF-β /Smad Inhibition in Rats. Annals of hepatology. 2018 Mar; 17(2):307-317. doi: 10.5604/01.3001.0010.8661. [PMID: 29469035]
  • Beatriz Valenzuela, Felipe E Rodríguez, Brenda Modak, Mónica Imarai. Alpinone exhibited immunomodulatory and antiviral activities in Atlantic salmon. Fish & shellfish immunology. 2018 Mar; 74(?):76-83. doi: 10.1016/j.fsi.2017.12.043. [PMID: 29292197]
  • Nimmy Kumar, Akhila H Shrungeswara, Sanchari B Mallik, Subhankar Biswas, Jesil Mathew, Krishnadas Nandakumar, Jessy Mathew, Richard Lobo. Pinocembrin-Enriched Fractions of Elytranthe parasitica (L.) Danser Modulates Apoptotic and MAPK Cellular Signaling in HepG2 Cells. Anti-cancer agents in medicinal chemistry. 2018; 18(11):1563-1572. doi: 10.2174/1871520618666180911112127. [PMID: 30205805]
  • Xiaoyan Gu, Qian Zhang, Qiang Du, Hong Shen, Zhenghua Zhu. Pinocembrin attenuates allergic airway inflammation via inhibition of NF-κB pathway in mice. International immunopharmacology. 2017 Dec; 53(?):90-95. doi: 10.1016/j.intimp.2017.10.005. [PMID: 29055190]
  • Hamza Hanieh, Villianur Ibrahim Hairul Islam, Subramanian Saravanan, Muthiah Chellappandian, Kessavane Ragul, Arumugam Durga, Kaliyamoorthy Venugopal, Venugopal Senthilkumar, Palanisamy Senthilkumar, Krishnaraj Thirugnanasambantham. Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro. European journal of pharmacology. 2017 Nov; 814(?):178-186. doi: 10.1016/j.ejphar.2017.08.012. [PMID: 28821452]
  • Nanaware Sadhana, Sathiyanarayanan Lohidasan, Kakasaheb Ramoo Mahadik. Marker-based standardization and investigation of nutraceutical potential of Indian propolis. Journal of integrative medicine. 2017 Nov; 15(6):483-494. doi: 10.1016/s2095-4964(17)60360-1. [PMID: 29103419]
  • Francesca Aiello, Biagio Armentano, Nicoletta Polerà, Gabriele Carullo, Monica Rosa Loizzo, Marco Bonesi, Maria Stella Cappello, Loredana Capobianco, Rosa Tundis. From Vegetable Waste to New Agents for Potential Health Applications: Antioxidant Properties and Effects of Extracts, Fractions and Pinocembrin from Glycyrrhiza glabra L. Aerial Parts on Viability of Five Human Cancer Cell Lines. Journal of agricultural and food chemistry. 2017 Sep; 65(36):7944-7954. doi: 10.1021/acs.jafc.7b03045. [PMID: 28862446]
  • Nimmy Kumar, Subhankar Biswas, Akhila Hosur Shrungeswara, Sanchari Basu Mallik, Mathew Hipolith Viji, Jessy Elizabeth Mathew, Jesil Mathew, K Nandakumar, Richard Lobo. Pinocembrin enriched fraction of Elytranthe parasitica (L.) Danser induces apoptosis in HCT 116 colorectal cancer cells. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2017 Jun; 23(6):354-359. doi: 10.1016/j.jiac.2017.02.009. [PMID: 28385566]
  • Marcos Roberto de Oliveira, Alessandra Peres, Gustavo Costa Ferreira. Pinocembrin Attenuates Mitochondrial Dysfunction in Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal: Role for the Erk1/2-Nrf2 Signaling Pathway. Neurochemical research. 2017 Apr; 42(4):1057-1072. doi: 10.1007/s11064-016-2140-5. [PMID: 28000163]
  • Juan Carlos Romero-Benavides, Ana Lucía Ruano, Ronal Silva-Rivas, Paola Castillo-Veintimilla, Sara Vivanco-Jaramillo, Natalia Bailon-Moscoso. Medicinal plants used as anthelmintics: Ethnomedical, pharmacological, and phytochemical studies. European journal of medicinal chemistry. 2017 Mar; 129(?):209-217. doi: 10.1016/j.ejmech.2017.02.005. [PMID: 28231520]
  • Yelin Kang, Bong-Gyu Kim, Sunghoon Kim, Youngshim Lee, Youngdae Yoon. Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. Bioorganic & medicinal chemistry letters. 2017 02; 27(3):420-426. doi: 10.1016/j.bmcl.2016.12.051. [PMID: 28049590]
  • Namrita Lall, Elizabeth Mogapi, Marco Nuno de Canha, Bridget Crampton, Mabatho Nqephe, Ahmed A Hussein, Vivek Kumar. Insights into tyrosinase inhibition by compounds isolated from Greyia radlkoferi Szyszyl using biological activity, molecular docking and gene expression analysis. Bioorganic & medicinal chemistry. 2016 11; 24(22):5953-5959. doi: 10.1016/j.bmc.2016.09.054. [PMID: 27720556]
  • Junjun Wu, Xia Zhang, Jingwen Zhou, Mingsheng Dong. Efficient biosynthesis of (2S)-pinocembrin from d-glucose by integrating engineering central metabolic pathways with a pH-shift control strategy. Bioresource technology. 2016 Oct; 218(?):999-1007. doi: 10.1016/j.biortech.2016.07.066. [PMID: 27450982]
  • Mohamed A Zaki, N P Dhammika Nanayakkara, Mona H Hetta, Melissa R Jacob, Shabana I Khan, Rabab Mohammed, Mohamed A Ibrahim, Volodymyr Samoylenko, Christina Coleman, Frank R Fronczek, Daneel Ferreira, Ilias Muhammad. Bioactive Formylated Flavonoids from Eugenia rigida: Isolation, Synthesis, and X-ray Crystallography. Journal of natural products. 2016 09; 79(9):2341-9. doi: 10.1021/acs.jnatprod.6b00474. [PMID: 27618204]
  • Yumin Wang, Yingchun Miao, Aamina Zia Mir, Long Cheng, Lina Wang, Linan Zhao, Qifu Cui, Weili Zhao, Hongquan Wang. Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cells. Journal of the neurological sciences. 2016 Sep; 368(?):223-30. doi: 10.1016/j.jns.2016.07.010. [PMID: 27538638]
  • Sib Sankar Giri, Shib Sankar Sen, Venkatachalam Sukumaran, Se Chang Park. Pinocembrin attenuates lipopolysaccharide-induced inflammatory responses in Labeo rohita macrophages via the suppression of the NF-κB signalling pathway. Fish & shellfish immunology. 2016 Sep; 56(?):459-466. doi: 10.1016/j.fsi.2016.07.038. [PMID: 27492123]
  • Sasivimon Promsan, Krit Jaikumkao, Anchalee Pongchaidecha, Nipon Chattipakorn, Varanuj Chatsudthipong, Phatchawan Arjinajarn, Wilart Pompimon, Anusorn Lungkaphin. Pinocembrin attenuates gentamicin-induced nephrotoxicity in rats. Canadian journal of physiology and pharmacology. 2016 Aug; 94(8):808-18. doi: 10.1139/cjpp-2015-0468. [PMID: 27245556]
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