NCBI Taxonomy: 130401

Piper hispidum (ncbi_taxid: 130401)

found 56 associated metabolites at species taxonomy rank level.

Ancestor: Piper

Child Taxonomies: none taxonomy data.

Pinocembrin

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (S)-(-)-

C15H12O4 (256.0736)


Pinocembrin is a dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea. It has a role as an antioxidant, an antineoplastic agent, a vasodilator agent, a neuroprotective agent and a metabolite. It is a dihydroxyflavanone and a (2S)-flavan-4-one. Pinocembrin is a natural product found in Prunus leveilleana, Alpinia rafflesiana, and other organisms with data available. Pinocembrin is found in mexican oregano and is isolated from many plants including food plants. Pinocembrin belongs to the family of flavanones. These are compounds containing a flavan-3-one moiety, which structure is characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a ketone at the carbon C3. A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea. Isolated from many plants including food plants. (S)-Pinocembrin is found in mexican oregano and pine nut. (±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line[1]. (±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line[1]. Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1]. Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1].

   

N-trans-feruloyltyramine

(Z,2E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enimidic acid

C18H19NO4 (313.1314)


N-feruloyltyramine is a member of tyramines. It has a role as a metabolite. Moupinamide is a natural product found in Zanthoxylum beecheyanum, Polyalthia suberosa, and other organisms with data available. See also: Tobacco Leaf (part of); Cannabis sativa subsp. indica top (part of); Ipomoea aquatica leaf (part of). Alkaloid from Piper nigrum. Moupinamide is found in many foods, some of which are nutmeg, amaranth, sapodilla, and orange bell pepper. Moupinamide is found in eggplant. Moupinamide is an alkaloid from Piper nigru CASMI2013 Challenge_1 MS2 data; [MS1] MSJ00001 CASMI2013 Challenge_1 MS1 data; [MS2] MSJ00002 N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid from Piper nigru, is an inhibitor of COX1 and COX2, with potential antioxidant properties. N-trans-Feruloyltyramine possesses anti-inflammatory activity[1]. N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid from Piper nigru, is an inhibitor of COX1 and COX2, with potential antioxidant properties. N-trans-Feruloyltyramine possesses anti-inflammatory activity[1].

   

2,2-Dimethyl-8-prenylchromene 6-carboxylic acid

2,2-dimethyl-8-(3-methylbut-2-enyl)chromene-6-carboxylic acid

C17H20O3 (272.1412)


2,2-Dimethyl-8-prenylchromene 6-carboxylic acid is a 1-benzopyran. 2,2-Dimethyl-8-prenylchromene 6-carboxylic acid is a natural product found in Piper aduncum and Piper hispidum with data available.

   

4-Hydroxy-3-prenylbenzoate

3-dimethylallyl-4-hydroxybenzoic acid

C12H14O3 (206.0943)


   

1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenyl-1-propanone

1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenylpropan-1-one

C16H16O4 (272.1049)


1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenyl-1-propanone is isolated from Populus balsamifera (balsam poplar) oi Isolated from Populus balsamifera (balsam poplar) oil.

   

Pinostrobin

(2R)-5-hydroxy-7-methoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one

C16H14O4 (270.0892)


A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively. Pinostrobin is a natural product found in Uvaria chamae, Zuccagnia punctata, and other organisms with data available.

   

1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

C16H14O4 (270.0892)


   

3-(6,7-dimethoxy-2H-1,3-benzodioxol-5-yl)prop-2-en-1-ol

3-(6,7-dimethoxy-2H-1,3-benzodioxol-5-yl)prop-2-en-1-ol

C12H14O5 (238.0841)


   

(2E)-Piperamide-C5:1

(2E)-5-(2H-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)pent-2-en-1-one

C16H19NO3 (273.1365)


(2E)-Piperamide-C5:1 is found in herbs and spices. (2E)-Piperamide-C5:1 is a constituent of pepper fruits (Piper nigrum, Piperaceae). Constituent of pepper fruits (Piper nigrum, Piperaceae). (2E)-Piperamide-C5:1 is found in herbs and spices and pepper (spice).

   

Dillapional

(2Z)-3-(6,7-dimethoxy-2H-1,3-benzodioxol-5-yl)prop-2-enal

C12H12O5 (236.0685)


Minor constituent of Anethum sowa (Indian dill) oil. Dillapional is found in dill and herbs and spices. Dillapional is found in dill. Dillapional is a minor constituent of Anethum sowa (Indian dill) oi

   

(2E)-1-(2,3-dihydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one

(2E)-1-(2,3-dihydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one

C17H16O5 (300.0998)


   

Bamipine

1-(1,2-diphenylethyl)-4-methylpiperazine

C19H24N2 (280.1939)


Bamipine is a first-generation piperidine H1-antihistamine.

   

(2R)-5-Hydroxy-7-methoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one

(2R)-5-hydroxy-7-methoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one

C16H14O4 (270.0892)


Pinostrobin, also known as 5-hydroxy-7-methoxyflavanone, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, pinostrobin is considered to be a flavonoid lipid molecule. Pinostrobin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Pinostrobin can be found in a number of food items such as roman camomile, soursop, rocket salad, and angelica, which makes pinostrobin a potential biomarker for the consumption of these food products.

   

Cardamomin

InChI=1/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7

C16H14O4 (270.0892)


Cardamonin is a member of chalcones. Cardamonin (also known as Dihydroxymethoxychalcone), as shown by the increasing number of publications, has received growing attention from the scientific community due to the expectations toward its benefits to human health. Cardamonins name comes from the fact that it can be found in cardamom spice. Cardamonin is a natural product found in Amomum subulatum, Alpinia blepharocalyx, and other organisms with data available. (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities[1][2].

   

2,4-dihydroxy-6-methoxychalcone

1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

C16H14O4 (270.0892)


Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities[1][2].

   

Cardamonin

(E) -2,4-Dihydroxy-6-methoxychalcone

C16H14O4 (270.0892)


(E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.

   

1,3-Benzodioxole, 4,5-dimethoxy-7-(2-propenyl)-

1,3-Benzodioxole, 4,5-dimethoxy-7-(2-propenyl)-

C12H14O4 (222.0892)


   

pinocembrine

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2R)-

C15H12O4 (256.0736)


4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2R)- is a natural product found in Alpinia nutans, Alpinia zerumbet, and Boesenbergia rotunda with data available.

   

Pinocembrin

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (S)-(-)-

C15H12O4 (256.0736)


(2s)-pinocembrin, also known as 5,7-dihydroxyflavanone or dihydrochrysin, is a member of the class of compounds known as flavanones. Flavanones are compounds containing a flavan-3-one moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a ketone at the carbon C3. Thus, (2s)-pinocembrin is considered to be a flavonoid lipid molecule (2s)-pinocembrin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). (2s)-pinocembrin can be found in a number of food items such as acorn, lentils, mulberry, and sorghum, which makes (2s)-pinocembrin a potential biomarker for the consumption of these food products. (s)-pinocembrin, also known as 5,7-dihydroxyflavanone or dihydrochrysin, is a member of the class of compounds known as flavanones. Flavanones are compounds containing a flavan-3-one moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a ketone at the carbon C3 (s)-pinocembrin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). (s)-pinocembrin is a bitter tasting compound found in mexican oregano and tarragon, which makes (s)-pinocembrin a potential biomarker for the consumption of these food products. relative retention time with respect to 9-anthracene Carboxylic Acid is 1.069 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.067 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.071 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.070 5,7-Dihydroxyflavanone is a natural product found in Pinus contorta var. latifolia, Piper nigrum, and other organisms with data available. (±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line[1]. (±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line[1]. Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1]. Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1].

   

1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenylpropan-1-one

NCGC00384536-01!1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenylpropan-1-one

C16H16O4 (272.1049)


   

Piperamide-C5:1 (2E)

(2E)-5-(2H-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)pent-2-en-1-one

C16H19NO3 (273.1365)


   

4-Hydroxy-3-(3-methylbut-2-en-1-yl)benzoic acid

4-hydroxy-3-(3-methylbut-2-enyl)benzoic acid

C12H14O3 (206.0943)


   

Pinocembrin-7-methyl ether

5-hydroxy-7-methoxy-2-phenylchroman-4-one

C16H14O4 (270.0892)


   

bamipine

bamipine

C19H24N2 (280.1939)


D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist

   

cardamomin

2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-, (2E)-

C16H14O4 (270.0892)


(E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities[1][2].

   

1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenylpropan-1-one

1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenylpropan-1-one

C16H16O4 (272.1049)


   

(2E)-Piperamide-C5:1

(2E)-Piperamide-C5:1

C16H19NO3 (273.1365)


   

5-(2h-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)pent-2-en-1-one

5-(2h-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)pent-2-en-1-one

C16H19NO3 (273.1365)


   

(2r,3r)-3-hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylic acid

(2r,3r)-3-hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylic acid

C12H14O5 (238.0841)


   

3-(6,7-dimethoxy-2h-1,3-benzodioxol-5-yl)prop-2-enal

3-(6,7-dimethoxy-2h-1,3-benzodioxol-5-yl)prop-2-enal

C12H12O5 (236.0685)


   

(2z,4z)-7-(2h-1,3-benzodioxol-5-yl)-n-(2-methylpropyl)hepta-2,4-dienimidic acid

(2z,4z)-7-(2h-1,3-benzodioxol-5-yl)-n-(2-methylpropyl)hepta-2,4-dienimidic acid

C18H23NO3 (301.1678)


   

3-hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylic acid

3-hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylic acid

C12H14O5 (238.0841)


   

3-(6-methoxy-2h-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-one

3-(6-methoxy-2h-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-one

C15H17NO4 (275.1158)


   

4-hydroxy-3,5-bis(3-methylbut-2-en-1-yl)benzoic acid

4-hydroxy-3,5-bis(3-methylbut-2-en-1-yl)benzoic acid

C17H22O3 (274.1569)


   

(2e)-3-(4-hydroxy-3-methoxyphenyl)-n-[2-(4-hydroxyphenyl)ethyl]prop-2-enimidic acid

(2e)-3-(4-hydroxy-3-methoxyphenyl)-n-[2-(4-hydroxyphenyl)ethyl]prop-2-enimidic acid

C18H19NO4 (313.1314)


   

(2e)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-phenylprop-2-en-1-one

(2e)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-phenylprop-2-en-1-one

C18H18O5 (314.1154)


   

methyl (2r,3r)-3-hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylate

methyl (2r,3r)-3-hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylate

C13H16O5 (252.0998)


   

2,2-dimethyl-8-(3-methylbut-2-en-1-yl)chromene-6-carboxylic acid

2,2-dimethyl-8-(3-methylbut-2-en-1-yl)chromene-6-carboxylic acid

C17H20O3 (272.1412)


   

(2r)-5,7,8-trimethoxy-2-phenyl-2,3-dihydro-1-benzopyran-4-one

(2r)-5,7,8-trimethoxy-2-phenyl-2,3-dihydro-1-benzopyran-4-one

C18H18O5 (314.1154)


   

methyl 3-hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylate

methyl 3-hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylate

C13H16O5 (252.0998)


   

(2z)-3-(6-methoxy-2h-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-one

(2z)-3-(6-methoxy-2h-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-one

C15H17NO4 (275.1158)


   

(2r)-8-hydroxy-5,7-dimethoxy-2-phenyl-2,3-dihydro-1-benzopyran-4-one

(2r)-8-hydroxy-5,7-dimethoxy-2-phenyl-2,3-dihydro-1-benzopyran-4-one

C17H16O5 (300.0998)


   

4,5-dimethoxy-7-(prop-2-en-1-yl)-2h-1,3-benzodioxole

4,5-dimethoxy-7-(prop-2-en-1-yl)-2h-1,3-benzodioxole

C12H14O4 (222.0892)


   

(2e)-3-(6,7-dimethoxy-2h-1,3-benzodioxol-5-yl)prop-2-en-1-ol

(2e)-3-(6,7-dimethoxy-2h-1,3-benzodioxol-5-yl)prop-2-en-1-ol

C12H14O5 (238.0841)


   

7-(2h-1,3-benzodioxol-5-yl)-n-(2-methylpropyl)hepta-2,4-dienimidic acid

7-(2h-1,3-benzodioxol-5-yl)-n-(2-methylpropyl)hepta-2,4-dienimidic acid

C18H23NO3 (301.1678)


   

3,5-bis(3-hydroxy-3-methylbut-1-en-1-yl)-4-methoxybenzoic acid

3,5-bis(3-hydroxy-3-methylbut-1-en-1-yl)-4-methoxybenzoic acid

C18H24O5 (320.1624)


   

2-hydroxy-n-methyl-n-[2-(3,4,5-trimethoxyphenyl)ethyl]benzamide

2-hydroxy-n-methyl-n-[2-(3,4,5-trimethoxyphenyl)ethyl]benzamide

C19H23NO5 (345.1576)


   

1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-phenylprop-2-en-1-one

1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-phenylprop-2-en-1-one

C18H18O5 (314.1154)


   

(2z,4z)-7-(2h-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)hepta-2,4-dien-1-one

(2z,4z)-7-(2h-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)hepta-2,4-dien-1-one

C18H21NO3 (299.1521)


   

7-(2h-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)hepta-2,4-dien-1-one

7-(2h-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)hepta-2,4-dien-1-one

C18H21NO3 (299.1521)


   

4-methoxy-3,5-bis(3-methylbut-2-en-1-yl)benzoic acid

4-methoxy-3,5-bis(3-methylbut-2-en-1-yl)benzoic acid

C18H24O3 (288.1725)


   

(2r)-6-hydroxy-5,7-dimethoxy-2-phenyl-2,3-dihydro-1-benzopyran-4-one

(2r)-6-hydroxy-5,7-dimethoxy-2-phenyl-2,3-dihydro-1-benzopyran-4-one

C17H16O5 (300.0998)


   

3-(4-hydroxy-3-methoxyphenyl)-n-[2-(4-hydroxyphenyl)ethyl]prop-2-enimidic acid

3-(4-hydroxy-3-methoxyphenyl)-n-[2-(4-hydroxyphenyl)ethyl]prop-2-enimidic acid

C18H19NO4 (313.1314)


   

(2e)-3-(6,7-dimethoxy-2h-1,3-benzodioxol-5-yl)prop-2-enal

(2e)-3-(6,7-dimethoxy-2h-1,3-benzodioxol-5-yl)prop-2-enal

C12H12O5 (236.0685)


   

6,7-dimethoxy-2h-1,3-benzodioxole-5-carbaldehyde

6,7-dimethoxy-2h-1,3-benzodioxole-5-carbaldehyde

C10H10O5 (210.0528)


   

3,5-bis[(1e)-3-hydroxy-3-methylbut-1-en-1-yl]-4-methoxybenzoic acid

3,5-bis[(1e)-3-hydroxy-3-methylbut-1-en-1-yl]-4-methoxybenzoic acid

C18H24O5 (320.1624)