Cinobufagin (BioDeep_00000000381)

 

Secondary id: BioDeep_00000637380

PANOMIX_OTCML-2023 Antitumor activity natural product


代谢物信息卡片


[(1R,2S,4R,5R,6R,7R,10S,11S,14S,16R)-14-hydroxy-7,11-dimethyl-6-(6-oxopyran-3-yl)-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-5-yl] acetate

化学式: C26H34O6 (442.2355)
中文名称: 华蟾酥毒基, 蟾酥
谱图信息: 最多检出来源 Viridiplantae(plant) 3.84%

分子结构信息

SMILES: C(OC(C5C(C=6)=COC(=O)C6)C(C(C52C)(C(C4)(C(C(C)(C([H])3C4)CCC(C3)O)(CC2)[H])[H])1)O1)(C)=O
InChI: InChI=1S/C26H34O6/c1-14(27)31-22-21(15-4-7-20(29)30-13-15)25(3)11-9-18-19(26(25)23(22)32-26)6-5-16-12-17(28)8-10-24(16,18)2/h4,7,13,16-19,21-23,28H,5-6,8-12H2,1-3H3

描述信息

Cinobufagin is a steroid lactone. It is functionally related to a bufanolide.
Cinobufagin is a natural product found in Bufo gargarizans, Phrynoidis asper, and other organisms with data available.
Cinobufagin is a bufadienolide compound extracted from the dried venom secreted by the parotid glands of toads and one of the glycosides in the traditional Chinese medicine ChanSu, with potential antineoplastic activity. Although the mechanism of action of cinobufagin is still under investigation, it has been found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators that include mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9. Possible upstream mediators of cinobufagin-induced apoptosis include Fas and p53.
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002018 - Bufanolides
Annotation level-1
Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models[1][2][3].
Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models[1][2][3].

同义名列表

17 个代谢物同义名

[(1R,2S,4R,5R,6R,7R,10S,11S,14S,16R)-14-hydroxy-7,11-dimethyl-6-(6-oxopyran-3-yl)-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-5-yl] acetate; BUFA-20,22-DIENOLIDE, 16-(ACETYLOXY)-14,15-EPOXY-3-HYDROXY-, (3- .BETA.,5-.BETA.,15-.BETA.,16-.BETA.)-; Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3-beta,5-beta,15-beta,16-beta)-; Bufa-20, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3.beta.,5.beta.,15.beta.,16.beta.)-; 5beta-bufa-20,22-dienolide, 14,15beta-epoxy-3beta,16beta-dihydroxy-, 16-acetate; 14,15beta-Epoxy-3beta,16beta-dihydroxy-5beta,20(22)-bufadienolide 16-acetate; 3beta-hydroxy-16beta-acetoxy-14beta,15beta-epoxy-5beta-bufa-20,22-dienolide; 5.beta.-Bufa-20, 14,15.beta.-epoxy-3.beta.,16.beta.-dihydroxy-, 16-acetate; Cinobufagin (Cinobufagine); CINOBUFAGIN [WHO-DD]; UNII-T9PSN4R8IR; Cinobufagine; Cino-bufagin; Cinobufagin; ST 26:6;O6; T9PSN4R8IR; Cinobufagin



数据库引用编号

45 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

39 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, ANXA5, BCL2, CASP3, CDK1, CTNNB1, EGFR, MTOR, MYC, PIK3CA, PIK3R6, POMC, STAT3, TP53
Peripheral membrane protein 3 ANXA5, MTOR, PIK3R6
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 5 BCL2, CD4, CDK1, EGFR, MTOR
Nucleus 11 AKT1, BCL2, CASP3, CDK1, CTNNB1, EGFR, MTOR, MYC, PARP1, STAT3, TP53
cytosol 12 AKT1, ANXA5, BCL2, CASP3, CDK1, CTNNB1, MTOR, PARP1, PIK3CA, PIK3R6, STAT3, TP53
dendrite 1 MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 3 CDK1, CTNNB1, TP53
nucleoplasm 10 AKT1, ATP2B1, CASP3, CDK1, CTNNB1, MTOR, MYC, PARP1, STAT3, TP53
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 6 AKT1, ATP2B1, CD4, CTNNB1, EGFR, PIK3R6
Cytoplasmic side 1 MTOR
lamellipodium 3 AKT1, CTNNB1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ATP2B1
Golgi apparatus membrane 1 MTOR
Synapse 2 ATP2B1, CTNNB1
cell cortex 2 AKT1, CTNNB1
cell junction 2 CTNNB1, EGFR
cell surface 1 EGFR
glutamatergic synapse 5 AKT1, ATP2B1, CASP3, CTNNB1, EGFR
Golgi membrane 2 EGFR, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 1 CASP3
postsynapse 1 AKT1
presynaptic membrane 2 ATP2B1, CTNNB1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 PARP1
Lysosome 1 MTOR
endosome 1 EGFR
plasma membrane 8 AKT1, ATP2B1, CD4, CTNNB1, EGFR, PIK3CA, PIK3R6, STAT3
synaptic vesicle membrane 1 ATP2B1
Membrane 12 AKT1, ANXA5, ATP2B1, BCL2, CDK1, CTNNB1, EGFR, MTOR, MYC, PARP1, PIK3R6, TP53
apical plasma membrane 1 EGFR
axon 1 CCK
basolateral plasma membrane 3 ATP2B1, CTNNB1, EGFR
extracellular exosome 4 ANXA5, ATP2B1, CDK1, CTNNB1
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 BCL2, TP53
extracellular space 5 CCK, EGFR, IL10, IL6, POMC
perinuclear region of cytoplasm 3 CTNNB1, EGFR, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CDK1, PARP1, TP53
protein-containing complex 7 AKT1, BCL2, CTNNB1, EGFR, MYC, PARP1, TP53
intracellular membrane-bounded organelle 1 ATP2B1
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 CD4, EGFR
Secreted 4 CCK, IL10, IL6, POMC
extracellular region 5 ANXA5, CCK, IL10, IL6, POMC
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CDK1, TP53
transcription regulator complex 4 CTNNB1, PARP1, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK1, TP53
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 2 ANXA5, CD4
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
nucleolus 3 MYC, PARP1, TP53
Wnt signalosome 1 CTNNB1
midbody 1 CDK1
Early endosome 1 CD4
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
Membrane raft 2 CD4, EGFR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
focal adhesion 3 ANXA5, CTNNB1, EGFR
spindle 1 AKT1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
intracellular vesicle 1 EGFR
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 POMC
fascia adherens 1 CTNNB1
lateral plasma membrane 2 ATP2B1, CTNNB1
receptor complex 1 EGFR
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 AKT1
chromatin 4 MYC, PARP1, STAT3, TP53
cell projection 1 ATP2B1
cell periphery 1 CTNNB1
mitotic spindle 1 CDK1
Chromosome 1 PARP1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 2 MYC, PARP1
spindle pole 1 CTNNB1
nuclear replication fork 1 PARP1
chromosome, telomeric region 2 CDK1, PARP1
postsynaptic density, intracellular component 1 CTNNB1
Basolateral cell membrane 1 ATP2B1
microvillus membrane 1 CTNNB1
site of double-strand break 2 PARP1, TP53
nuclear envelope 3 MTOR, MYC, PARP1
Endomembrane system 2 CTNNB1, MTOR
Nucleus, nucleoplasm 1 MYC
euchromatin 1 CTNNB1
Presynaptic cell membrane 1 ATP2B1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 POMC
endoplasmic reticulum lumen 2 CD4, IL6
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 2 PIK3CA, PIK3R6
phosphatidylinositol 3-kinase complex, class IA 2 PIK3CA, PIK3R6
RNA polymerase II transcription repressor complex 1 MYC
beta-catenin-TCF complex 1 CTNNB1
immunological synapse 1 ATP2B1
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 2 CD4, EGFR
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 2 CTNNB1, PARP1
spindle microtubule 1 CDK1
death-inducing signaling complex 1 CASP3
Rough endoplasmic reticulum 1 MYC
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 1 CDK1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Myc-Max complex 1 MYC
T cell receptor complex 1 CD4
interleukin-6 receptor complex 1 IL6
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 2 PIK3CA, PIK3R6
nucleoplasmic reticulum 1 MYC


文献列表

  • Meng Wang, Yueyue Li, Shanshan Li, Ting Wang, Manman Wang, Huan Wu, Mei Zhang, Shengyong Luo, Cheng Zhao, Qinglin Li, Hui Cheng. Cinobufacini injection delays hepatocellular carcinoma progression by regulating lipid metabolism via SREBP1 signaling pathway and affecting macrophage polarization. Journal of ethnopharmacology. 2024 Mar; 321(?):117472. doi: 10.1016/j.jep.2023.117472. [PMID: 37995825]
  • Rong-Rong Zhang, Ming-Yi Shao, Yu Fu, Rui-Xia Zhao, Jing-Wen Wnag, Yu-Xuan Fang. Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis. Chinese journal of integrative medicine. 2023 Sep; ?(?):. doi: 10.1007/s11655-023-3704-2. [PMID: 37697203]
  • Qinhang Wu, Xuelin Ma, Zhuolin Jin, Ruijun Ni, Yang Pan, Guangming Yang. Zhuidu Formula suppresses the migratory and invasive properties of triple-negative breast cancer cells via dual signaling pathways of RhoA/ROCK and CDC42/MRCK. Journal of ethnopharmacology. 2023 May; ?(?):116644. doi: 10.1016/j.jep.2023.116644. [PMID: 37196814]
  • Ailin Yang, Qi Wu, Anmei Wang, Qimei Chen, Jingyi Yang, Yufan Tao, Yixuan Sun, Jiayu Zhang. Integrated transcriptomics and metabolomics analyses to investigate the anticancer mechanisms of cinobufagin against liver cancer through interfering with lipid, amino acid, carbohydrate, and nucleotide metabolism. Bioorganic chemistry. 2023 01; 130(?):106229. doi: 10.1016/j.bioorg.2022.106229. [PMID: 36335648]
  • Xiucai Ma, Zhigang Suo, Xiaoyan Ma, Chunrui Zhan, Guodong Luo, Jianmin Song. Cinobufagin inhibits tumor progression and reduces doxorubicin resistance by enhancing FOXO1-mediated transcription of FCGBP in osteosarcoma. Journal of ethnopharmacology. 2022 Oct; 296(?):115433. doi: 10.1016/j.jep.2022.115433. [PMID: 35690338]
  • Lingling Zhang, Bing Liang, Huan Xu, Yanju Gong, Wangming Hu, Zhong Jin, Xiao Wu, Xiongbin Chen, Min Li, Liangqin Shi, Yaping Shi, Yong Wang, Lan Yang. Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and invasion by inhibiting G9a in non-small-cell lung cancer A549 cells. Journal of ethnopharmacology. 2022 Jun; 291(?):115095. doi: 10.1016/j.jep.2022.115095. [PMID: 35176466]
  • Ailin Yang, Qi Wu, Qimei Chen, Jingyi Yang, Haoran Li, Yufan Tao, Anmei Wang, Yaxue Sun, Jiayu Zhang. Cinobufagin restrains the growth and triggers DNA damage of human hepatocellular carcinoma cells via proteasome-dependent degradation of thymidylate synthase. Chemico-biological interactions. 2022 Jun; 360(?):109938. doi: 10.1016/j.cbi.2022.109938. [PMID: 35427566]
  • Rentao Hou, Xiong Liu, Huiling Yang, Shuting Deng, Chao Cheng, Jiahao Liu, Yonghao Li, Yewei Zhang, Jingwen Jiang, Zhibo Zhu, Yun Su, Liyang Wu, Yingying Xie, Xiaoning Li, Wenmin Li, Zhen Liu, Weiyi Fang. Chemically synthesized cinobufagin suppresses nasopharyngeal carcinoma metastasis by inducing ENKUR to stabilize p53 expression. Cancer letters. 2022 04; 531(?):57-70. doi: 10.1016/j.canlet.2022.01.025. [PMID: 35114328]
  • Xue Zhang, Lei Wang, Qi Zhang, Song Lyu, Darong Zhu, Mengzhen Shen, Xisong Ke, Yi Qu. Small molecule targeting topoisomerase 3β for cancer therapy. Pharmacological research. 2021 12; 174(?):105927. doi: 10.1016/j.phrs.2021.105927. [PMID: 34740818]
  • Ai-Lin Yang, Qi Wu, Zhong-Dong Hu, Shao-Ping Wang, Yu-Fan Tao, An-Mei Wang, Yi-Xuan Sun, Xiu-Lian Li, Long Dai, Jiayu Zhang. A network pharmacology approach to investigate the anticancer mechanism of cinobufagin against hepatocellular carcinoma via downregulation of EGFR-CDK2 signaling. Toxicology and applied pharmacology. 2021 11; 431(?):115739. doi: 10.1016/j.taap.2021.115739. [PMID: 34619160]
  • Candelario Rodriguez, Roberto Ibáñez, Luis Mojica, Michelle Ng, Carmenza Spadafora, Armando A Durant-Archibold, Marcelino Gutiérrez. Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi. Molecules (Basel, Switzerland). 2021 Jul; 26(14):. doi: 10.3390/molecules26144217. [PMID: 34299492]
  • Wei-Song Kong, Fang-Xue Shen, Rui-Fang Xie, Gui Zhou, Yi-Ming Feng, Xin Zhou. Bufothionine induces autophagy in H22 hepatoma-bearing mice by inhibiting JAK2/STAT3 pathway, a possible anti-cancer mechanism of cinobufacini. Journal of ethnopharmacology. 2021 Apr; 270(?):113848. doi: 10.1016/j.jep.2021.113848. [PMID: 33485977]
  • Yang Zhou, Jinjun Hou, Huali Long, Zijia Zhang, Min Lei, Wanying Wu. Design, synthesis and anti-tumor activities of carbamate derivatives of cinobufagin. Steroids. 2020 12; 164(?):108749. doi: 10.1016/j.steroids.2020.108749. [PMID: 33065151]
  • Qian Li, Ren-Long Liang, Qian-Ru Yu, De-Qing Tian, Li-Na Zhao, Wen-Wen Wang, Hua Xiao, Xiao-Jia Yong, Xiao-Dong Peng. Efficacy and safety of cinobufacini injection combined with vinorelbine and cisplatin regimen chemotherapy for stage III/IV non-small cell lung cancer: A protocol for systematic review and meta-analysis of randomized controlled trials. Medicine. 2020 Jul; 99(31):e21539. doi: 10.1097/md.0000000000021539. [PMID: 32756206]
  • Jinghui Zhang, Yanjun Hong, Lilong Jiang, Xiaojiao Yi, Yang Chen, Li Liu, Zhongjian Chen, Yongjiang Wu, Zongwei Cai. Global Metabolomic and Lipidomic Analysis Reveal the Synergistic Effect of Bufalin in Combination with Cinobufagin against HepG2 Cells. Journal of proteome research. 2020 02; 19(2):873-883. doi: 10.1021/acs.jproteome.9b00681. [PMID: 31942794]
  • Zhaohai Pan, Yongchuan Luo, Yuan Xia, Xin Zhang, Yao Qin, Wenjing Liu, Minjing Li, Xiaona Liu, Qiusheng Zheng, Defang Li. Cinobufagin induces cell cycle arrest at the S phase and promotes apoptosis in nasopharyngeal carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Feb; 122(?):109763. doi: 10.1016/j.biopha.2019.109763. [PMID: 31918288]
  • Longsheng Xu, Shizhen Wang, Hui Shen, Qingli Feng, Xiaoping Zhang, Huadong Ni, Ming Yao. Analgesic and toxic effects of venenum bufonis and its constituent compound cinobufagin: A comparative study. Neurotoxicology and teratology. 2019 May; 73(?):49-53. doi: 10.1016/j.ntt.2019.03.004. [PMID: 30943443]
  • Xiaowu Li, Chunhui Chen, Yu Dai, Chengzhi Huang, Qinrui Han, Linlin Jing, Ye Ma, Yihua Xu, Yawei Liu, Liang Zhao, Junjiang Wang, Xuegang Sun, Xueqing Yao. Cinobufagin suppresses colorectal cancer angiogenesis by disrupting the endothelial mammalian target of rapamycin/hypoxia-inducible factor 1α axis. Cancer science. 2019 May; 110(5):1724-1734. doi: 10.1111/cas.13988. [PMID: 30839155]
  • Xu Deng, Jiexia Sheng, Hua Liu, Nannan Wang, Cuoji Dai, Zhenguo Wang, Jing Zhang, Jianye Zhao, Erqing Dai. Cinobufagin Promotes Cell Cycle Arrest and Apoptosis to Block Human Esophageal Squamous Cell Carcinoma Cells Growth via the p73 Signalling Pathway. Biological & pharmaceutical bulletin. 2019; 42(9):1500-1509. doi: 10.1248/bpb.b19-00174. [PMID: 31474710]
  • Jin-Hua Guo, Ren-Wang Jiang, Jacob Lauwring Andersen, Mikael Esmann, Natalya U Fedosova. Spin-labeled derivatives of cardiotonic steroids as tools for characterization of the extracellular entrance to the binding site on Na+ ,K+ -ATPase. The FEBS journal. 2018 06; 285(12):2292-2305. doi: 10.1111/febs.14480. [PMID: 29688626]
  • Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero. Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy. Journal of natural products. 2017 10; 80(10):2602-2608. doi: 10.1021/acs.jnatprod.6b01052. [PMID: 29043803]
  • Zeting Yuan, Xiaojing Shi, Yanyan Qiu, Tingting Jia, Xia Yuan, Yu Zou, Cheng Liu, Hui Yu, Yuxia Yuan, Xue He, Ke Xu, Peihao Yin. Reversal of P-gp-mediated multidrug resistance in colon cancer by cinobufagin. Oncology reports. 2017 Mar; 37(3):1815-1825. doi: 10.3892/or.2017.5410. [PMID: 28184922]
  • Tao Chen, Shenjun Yuan, Xin-Nian Wan, Ling Zhan, Xue-Qin Yu, Jian-Hong Zeng, Hong Li, Wen Zhang, Xiang-Yang Hu, Yi-Fei Ye, Wei Hu. Chinese herb cinobufagin-reduced cancer pain is associated with increased peripheral opioids by invaded CD3/4/8 lymphocytes. Oncotarget. 2017 Feb; 8(7):11425-11441. doi: 10.18632/oncotarget.14005. [PMID: 28002791]
  • Shuai-Cheng Wu, Peng-Fei Yi, Xun Guo, Li-Yan Zhang, Dao-Xiu Xu, Yun-Xing Fu, Zhen-Qiang Cui, Hai-Qing Shen, Xu-Bin Wei, Ben-Dong Fu. Cinobufagin enhances the protective efficacy of formalin-inactivated Salmonella typhimurium vaccine through Th1 immune response. Microbial pathogenesis. 2016 Oct; 99(?):264-270. doi: 10.1016/j.micpath.2016.08.036. [PMID: 27574776]
  • Shanshan Xie, Laura Spelmink, Mario Codemo, Karthik Subramanian, Katrin Pütsep, Birgitta Henriques-Normark, Marie Olliver. Cinobufagin Modulates Human Innate Immune Responses and Triggers Antibacterial Activity. PloS one. 2016; 11(8):e0160734. doi: 10.1371/journal.pone.0160734. [PMID: 27529866]
  • Jing Zhou, Yan Gong, Hongyue Ma, Honglan Wang, Dawei Qian, Hongmei Wen, Rui Liu, Jinao Duan, Qinan Wu. Effect of drying methods on the free and conjugated bufadienolide content in toad venom determined by ultra-performance liquid chromatography-triple quadrupole mass spectrometry coupled with a pattern recognition approach. Journal of pharmaceutical and biomedical analysis. 2015 Oct; 114(?):482-7. doi: 10.1016/j.jpba.2015.05.032. [PMID: 26186722]
  • Hai-Yan Tian, Shi-Lin Luo, Jun-Shan Liu, Lei Wang, Ying Wang, Dong-Mei Zhang, Xiao-Qi Zhang, Ren-Wang Jiang, Wen-Cai Ye. C23 steroids from the venom of Bufo bufo gargarizans. Journal of natural products. 2013 Oct; 76(10):1842-7. doi: 10.1021/np400174f. [PMID: 24050254]
  • Dong-Mei Zhang, Jun-Shan Liu, Ming-Kuen Tang, Anita Yiu, Hui-hui Cao, Lei Jiang, Judy Yuet-Wa Chan, Hai-Yan Tian, Kwok-Pui Fung, Wen-Cai Ye. Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. European journal of pharmacology. 2012 Oct; 692(1-3):19-28. doi: 10.1016/j.ejphar.2012.06.045. [PMID: 22841670]
  • Ying Xiao, Yu-Bin Zhao, Yan-Ming Xie. [Experimental study of suspicious sensitization component screening on Huachansu injection]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Sep; 37(18):2824-7. doi: . [PMID: 23285945]
  • Wei Cao, Yan Chen, Ling Yuan, Jun-Jie He. [Determination of protein binding rates of cinobufagin and resibufogenin with different plasmas by HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Sep; 47(9):1200-4. doi: . [PMID: 23227551]
  • Rui-Fang Xie, Zhi-Cheng Li, Bo Gao, Zhi-Na Shi, Xin Zhou. Bufothionine, a possible effective component in cinobufocini injection for hepatocellular carcinoma. Journal of ethnopharmacology. 2012 Jun; 141(2):692-700. doi: 10.1016/j.jep.2011.12.018. [PMID: 22210051]
  • Bo Jiang, Fei Cai, Shouhong Gao, Liyuan Meng, Fengying Liang, Xiao Dai, Wen Xu, Wansheng Chen. Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components. Chemico-biological interactions. 2012 Jan; 195(2):105-13. doi: 10.1016/j.cbi.2011.12.001. [PMID: 22178124]
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