Chemical Formula: C26H34O6
Chemical Formula C26H34O6
Found 57 metabolite its formula value is C26H34O6
Cinobufagin
Cinobufagin is a steroid lactone. It is functionally related to a bufanolide. Cinobufagin is a natural product found in Bufo gargarizans, Phrynoidis asper, and other organisms with data available. Cinobufagin is a bufadienolide compound extracted from the dried venom secreted by the parotid glands of toads and one of the glycosides in the traditional Chinese medicine ChanSu, with potential antineoplastic activity. Although the mechanism of action of cinobufagin is still under investigation, it has been found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators that include mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9. Possible upstream mediators of cinobufagin-induced apoptosis include Fas and p53. D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002018 - Bufanolides Annotation level-1 Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models[1][2][3]. Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models[1][2][3].
Pectachol
Pectachol is found in tea. Pectachol is a constituent of Artemisia abrotanum (southernwood) leaves. Constituent of Artemisia abrotanum (southernwood) leaves. Pectachol is found in tea.
3-O-Acetylepisamarcandin
3-O-Acetylepisamarcandin is found in green vegetables. 3-O-Acetylepisamarcandin is isolated from Ferula assa-foetida (asafoetida Isolated from Ferula assa-foetida (asafoetida). 3-O-Acetylepisamarcandin is found in herbs and spices and green vegetables.
[(2S,4R,5R,6R,14S,16R)-14-Hydroxy-7,11-dimethyl-6-(2-oxopyran-4-yl)-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-5-yl] acetate
Cinobufagin
[1R-(1alpha,2beta,4abeta,5beta,6beta,8aalpha)]-Decahydro-8a-methyl-4-methylene-6-(1-methylethyl)-1,2,5-naphthalenetriol 1,2-diacetate 5-benzoate
1beta-acetoxy-9alpha-beta-phenyloxacyclobutanoyloxy-beta-dihydroagarofuran
5,7-dihydroxy-4-(1-hydroxypropyl)-6-[(2E)-3,7-dimethyl-2,6-octadienyl]-8-(1-oxobutyl)-2H-benzopyran-2-one|kayeassamin A
5,7-dihydroxy-4-(1-hydroxypropyl)-6-(1-oxobutyl)-8-[(2E)-3,7-dimethyl-2,6-octadienyl]-2H-benzopyran-2-one|kayeassamin B
6-acetyl-8-t-cinnamyl-1alpha,10beta-epoxyantakyatriol
6-acetyl-8-t-cinnamyl-4beta,5alpha-epoxyantakyatriol
Englerin A
Englerin A is a guaiane sesquiterpenoid that is isolated from the bark of Phyllanthus engleri, a plant native to Tanzania and Zimbabwe. It acts as a potent and specific inhibitor of renal cancer cell growth. It has a role as a metabolite and an antineoplastic agent. It is a guaiane sesquiterpenoid, a cinnamate ester and a glycolate ester. Englerin A is a natural product found in Phyllanthus engleri with data available. A guaiane sesquiterpenoid that is isolated from the bark of Phyllanthus engleri, a plant native to Tanzania and Zimbabwe. It acts as a potent and specific inhibitor of renal cancer cell growth. Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload[1][2][3].