Hesperetin (BioDeep_00000000365)

 

Secondary id: BioDeep_00000017486, BioDeep_00000398535

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs Antitumor activity BioNovoGene_Lab2019


代谢物信息卡片


(2S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one (Hesperetin)

化学式: C16H14O6 (302.079)
中文名称: 橙皮素, 橙皮甙
谱图信息: 最多检出来源 Homo sapiens(feces) 21.41%

分子结构信息

SMILES: C1(O)C=C2O[C@H](C3=CC=C(OC)C(O)=C3)CC(=O)C2=C(O)C=1
InChI: InChI=1/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1

描述信息

Hesperetin, also known as prestwick_908 or YSO2, belongs to the class of organic compounds known as 4-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C4 atom of the flavonoid backbone. Thus, hesperetin is considered to be a flavonoid lipid molecule. Hesperetin also seems to upregulate the LDL receptor. Hesperetin, in the form of its glycoside , is the predominant flavonoid in lemons and oranges. Hesperetin is a drug which is used for lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity. Hesperetin is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. Hesperetin is a bitter tasting compound. Hesperetin is found, on average, in the highest concentration within a few different foods, such as limes, persian limes, and sweet oranges and in a lower concentration in pummelo, welsh onions, and lemons. Hesperetin has also been detected, but not quantified, in several different foods, such as yellow bell peppers, carrots, rapinis, hazelnuts, and beers. Hesperetin is a biomarker for the consumption of citrus fruits. Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity.
Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3-, 5- and 7-positions and an additional methoxy substituent at the 4-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3-hydroxyflavanones and a member of 4-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside [hesperidin], is the predominant flavonoid in lemons and oranges.
Hesperetin is a natural product found in Brassica oleracea var. sabauda, Dalbergia parviflora, and other organisms with data available.
Isolated from Mentha (peppermint) and numerous Citrussubspecies, with lemons, tangerines and oranges being especially good sources. Nutriceutical with anti-cancer props. Glycosides also widely distributed
A trihydroxyflavanone having the three hydroxy gropus located at the 3-, 5- and 7-positions and an additional methoxy substituent at the 4-position.
Acquisition and generation of the data is financially supported in part by CREST/JST.
[Raw Data] CB046_Hesperetin_pos_40eV_CB000021.txt
[Raw Data] CB046_Hesperetin_pos_50eV_CB000021.txt
[Raw Data] CB046_Hesperetin_pos_30eV_CB000021.txt
[Raw Data] CB046_Hesperetin_pos_20eV_CB000021.txt
[Raw Data] CB046_Hesperetin_pos_10eV_CB000021.txt
[Raw Data] CB046_Hesperetin_neg_20eV_000014.txt
[Raw Data] CB046_Hesperetin_neg_10eV_000014.txt
[Raw Data] CB046_Hesperetin_neg_40eV_000014.txt
[Raw Data] CB046_Hesperetin_neg_50eV_000014.txt
[Raw Data] CB046_Hesperetin_neg_30eV_000014.txt
Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.
Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.

同义名列表

64 个代谢物同义名

(2S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one (Hesperetin); 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-; 4H-1-Benzopyran-4-one,2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-; (2s)-5,7-Dihydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-2,3-Dihydro-4h-1-Benzopyran-4-One; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one; (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 2,3-DIHYDRO-5,7-DIHYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one; (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone; (S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one;Hesperetin; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one; (S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one; 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone; Flavanone, 3,5,7-trihydroxy-4-methoxy- (VAN) (8CI); Flavanone, 3,5, 7-trihydroxy-4-methoxy- (VAN); Flavanone, 3,5,7-trihydroxy-4-methoxy- (VAN); Hesperitin; Hesperin; YSO2; Prestwick_908; Flavanone, 3,5,7-trihydroxy-4-methoxy-; 5,7, 3-Trihydroxy-4-methoxyflavanone; 3,5,7-trihydroxy-4-methoxyflavanone; 4-Methoxy-3,5,7-trihydroxyflavanone; 5,7,3-Trihydroxy-4-methoxyflavanone; Cyanidanon 4-methyl ether 1626; Eriodictyol 4-monomethyl ether; (-)-(S)-hesperetin; HESPERETIN [INCI]; Prestwick3_000124; Prestwick0_000124; Prestwick2_000124; HESPERETIN [FHFI]; Prestwick1_000124; Spectrum3_001104; Spectrum2_001793; Spectrum5_000683; Spectrum4_001935; BCBcMAP01_000087; HESPERETIN [MI]; UNII-Q9Q3D557F1; (+-)-Hesperetin; (2S)-hesperetin; (-)-hesperetin; DivK1c_001039; Oprea1_828704; BPBio1_000186; Prestwick_908; KBio2_005797; KBio2_000661; KBio2_003229; KBio3_002028; KBio1_001039; Hesperitine; IDI1_001039; SMP1_000148; Q9Q3D557F1; Hesperetin; hesperitin; Hesperin; NP-13; YSO2; 6JP; Hesperetin



数据库引用编号

47 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

207 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, BCL2, MAPK14, MAPK8, NFE2L2, NOS2, PIK3CA, PTGS2, STAT3, TP53, XDH
Peripheral membrane protein 2 ACHE, PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 9 ACHE, AKT1, BCL2, MAPK14, MAPK8, NFE2L2, NOS2, STAT3, TP53
cytosol 11 AKT1, BCL2, GSR, MAPK14, MAPK8, NFE2L2, NOS2, PIK3CA, STAT3, TP53, XDH
centrosome 2 NFE2L2, TP53
nucleoplasm 7 AKT1, MAPK14, MAPK8, NFE2L2, NOS2, STAT3, TP53
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 3 ACHE, AKT1, TNF
lamellipodium 2 AKT1, PIK3CA
Synapse 2 ACHE, MAPK8
cell cortex 1 AKT1
cell surface 2 ACHE, TNF
glutamatergic synapse 2 AKT1, MAPK14
Golgi apparatus 2 ACHE, NFE2L2
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 2 NFE2L2, NOS2
plasma membrane 9 ACHE, AKT1, BCHE, NFE2L2, NOS2, PIK3CA, STAT3, TMPRSS11A, TNF
Membrane 5 ACHE, AKT1, BCL2, TMPRSS11A, TP53
axon 2 CCK, MAPK8
caveola 1 PTGS2
extracellular exosome 1 GSR
endoplasmic reticulum 3 BCL2, PTGS2, TP53
extracellular space 8 ACHE, BCHE, CCK, IL10, IL6, INS, TNF, XDH
perinuclear region of cytoplasm 3 ACHE, NOS2, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, GSR, MAPK14, TP53
protein-containing complex 4 AKT1, BCL2, PTGS2, TP53
Microsome membrane 1 PTGS2
Secreted 6 ACHE, BCHE, CCK, IL10, IL6, INS
extracellular region 9 ACHE, BCHE, CCK, IL10, IL6, INS, MAPK14, TMPRSS11A, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 GSR, TP53
Extracellular side 1 ACHE
transcription regulator complex 2 STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 GSR, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 2 TMPRSS11A, TNF
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
spindle 1 AKT1
Peroxisome 2 NOS2, XDH
basement membrane 1 ACHE
sarcoplasmic reticulum 1 XDH
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 3 NFE2L2, STAT3, TP53
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
spindle pole 1 MAPK14
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
endosome lumen 1 INS
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BCHE, IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
nuclear envelope lumen 1 BCHE
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 ACHE
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Álvaro Pérez-Valero, Juan Serna-Diestro, Albert Tafur Rangel, Simona Barbuto Ferraiuolo, Chiara Schiraldi, Eduard J Kerkhoven, Claudio J Villar, Felipe Lombó. Biosynthesis of Hesperetin, Homoeriodictyol, and Homohesperetin in a Transcriptomics-Driven Engineered Strain of Streptomyces albidoflavus. International journal of molecular sciences. 2024 Apr; 25(7):. doi: 10.3390/ijms25074053. [PMID: 38612864]
  • Adeola Oluwatosin Adedara, Getúlio Nicola Bressan, Matheus Mulling Dos Santos, Roselei Fachinetto, Amos Olalekan Abolaji, Nilda Vargas Barbosa. Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster. Neurotoxicology. 2024 Mar; 101(?):117-127. doi: 10.1016/j.neuro.2024.02.006. [PMID: 38423185]
  • Xianbin Yu, Zhixuan Liu, Yitian Yu, Chengjie Qian, Yuzhe Lin, Shuqing Jin, Long Wu, Shi Li. Hesperetin promotes diabetic wound healing by inhibiting ferroptosis through the activation of SIRT3. Phytotherapy research : PTR. 2024 Jan; ?(?):. doi: 10.1002/ptr.8121. [PMID: 38234096]
  • Erik K R Hanko, João Correia, Caio S Souza, Alison Green, Jakub Chromy, Ruth Stoney, Cunyu Yan, Eriko Takano, Diana Lousa, Cláudio M Soares, Rainer Breitling. Microbial production of the plant flavanone hesperetin from caffeic acid. BMC research notes. 2023 Nov; 16(1):343. doi: 10.1186/s13104-023-06620-8. [PMID: 37978406]
  • Wenqian Wang, Lili Qu, Zhan Cui, Fuping Lu, Li Li, Fufeng Liu. Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies. Journal of agricultural and food chemistry. 2023 Nov; 71(43):16174-16183. doi: 10.1021/acs.jafc.3c06816. [PMID: 37870747]
  • Juan Liu, Zhiqiang Xiao, Siqi Zhang, Zhen Wang, Yun Chen, Yang Shan. Restricting Promiscuity of Plant Flavonoid 3'-Hydroxylase and 4'-O-Methyltransferase Improves the Biosynthesis of (2S)-Hesperetin in E. coli. Journal of agricultural and food chemistry. 2023 Jun; ?(?):. doi: 10.1021/acs.jafc.3c02071. [PMID: 37310069]
  • Lukas Babylon, Julia Meißner, Gunter P Eckert. Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210029. [PMID: 37373177]
  • Yuri Doki, Yosuke Nakazawa, Naoki Morishita, Shin Endo, Noriaki Nagai, Naoki Yamamoto, Hiroomi Tamura, Megumi Funakoshi-Tago. Hesperetin treatment attenuates glycation of lens proteins and advanced‑glycation end products generation. Molecular medicine reports. 2023 05; 27(5):. doi: 10.3892/mmr.2023.12990. [PMID: 36999595]
  • Panpan Liu, Jian Chen, Jiaying Qi, Miaomiao Liu, Muqing Zhang, Yucong Xue, Li Li, Yanshuang Liu, Jing Shi, Yixin Zhang, Li Chu. Hesperetin ameliorates ischemia/hypoxia-induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca2+ homeostasis. Phytotherapy research : PTR. 2023 May; 37(5):1787-1805. doi: 10.1002/ptr.7693. [PMID: 36437582]
  • Ah Young Yang, Hye Jin Choi, Kiryeong Kim, Jaechan Leem. Antioxidant, Antiapoptotic, and Anti-Inflammatory Effects of Hesperetin in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062759. [PMID: 36985731]
  • Kamil Wdowiak, Andrzej Miklaszewski, Robert Pietrzak, Judyta Cielecka-Piontek. Amorphous System of Hesperetin and Piperine-Improvement of Apparent Solubility, Permeability, and Biological Activities. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24054859. [PMID: 36902286]
  • Lulu Shi, Mingzhe Zou, Xingxing Zhou, Songhua Wang, Wei Meng, Zhou Lan. Comparison of protective effects of hesperetin and pectolinarigenin on high-fat diet-induced hyperlipidemia and hepatic steatosis in Golden Syrian hamsters. Experimental animals. 2023 Feb; 72(1):123-131. doi: 10.1538/expanim.22-0115. [PMID: 36310057]
  • Yogesh Chand Yadav, Satyanarayan Pattnaik. Hesperetin-loaded polymeric nanofibers: assessment of bioavailability and neuroprotective effect. Drug development and industrial pharmacy. 2023 Feb; 49(2):240-247. doi: 10.1080/03639045.2023.2201625. [PMID: 37032647]
  • Parth Malik, Manju Bernela, Mahima Seth, Priya Kaushal, Tapan Kumar Mukherjee. Recent Progress in the Hesperetin Delivery Regimes: Significance of Pleiotropic Actions and Synergistic Anticancer Efficacy. Current pharmaceutical design. 2023; 29(37):2954-2976. doi: 10.2174/0113816128253609231030070414. [PMID: 38173051]
  • Sai Zhu, Xin Chen, Si-Yu Chen, Ao Wang, Sha Wu, Yuan-Yuan Wu, Miao Cheng, Jin-Jin Xu, Xiao-Feng Li, Cheng Huang, Jun Li. Hesperetin derivative decreases CCl4 -induced hepatic fibrosis by Ptch1-dependent mechanisms. Journal of biochemical and molecular toxicology. 2022 Oct; 36(10):e23149. doi: 10.1002/jbt.23149. [PMID: 35712856]
  • Fatemeh Omidfar, Fatemeh Gheybi, Javid Davoodi, Mostafa Amirinejad, Ali Badiee. Nanophytosomes of hesperidin and of hesperetin: Preparation, characterization, and in vivo evaluation. Biotechnology and applied biochemistry. 2022 Sep; ?(?):. doi: 10.1002/bab.2404. [PMID: 36112716]
  • Punnida Arjsri, Kamonwan Srisawad, Sariya Mapoung, Warathit Semmarath, Pilaiporn Thippraphan, Sonthaya Umsumarng, Supachai Yodkeeree, Pornngarm Dejkriengkraikul. Hesperetin from Root Extract of Clerodendrum petasites S. Moore Inhibits SARS-CoV-2 Spike Protein S1 Subunit-Induced NLRP3 Inflammasome in A549 Lung Cells via Modulation of the Akt/MAPK/AP-1 Pathway. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810346. [PMID: 36142258]
  • Lizha Mary Lazer, Yasodha Kesavan, Ravi Gor, Ilangovan Ramachandran, Surajit Pathak, Shoba Narayan, Muralidharan Anbalagan, Satish Ramalingam. Targeting colon cancer stem cells using novel doublecortin like kinase 1 antibody functionalized folic acid conjugated hesperetin encapsulated chitosan nanoparticles. Colloids and surfaces. B, Biointerfaces. 2022 Sep; 217(?):112612. doi: 10.1016/j.colsurfb.2022.112612. [PMID: 35738074]
  • Alpa Shree, Johirul Islam, Vikas Yadav, Sarwat Sultana, Haider Ali Khan. Hesperetin alleviates DMH induced toxicity via suppressing oxidative stress and inflammation in the colon of Wistar rats. Environmental toxicology. 2022 Sep; 37(9):2153-2166. doi: 10.1002/tox.23558. [PMID: 35567572]
  • Lateefat T Olumegbon, Akeem O Lawal, Dare M Oluyede, Monsurat O Adebimpe, Olusola O Elekofehinti, Haruna I Umar. Hesperetin protects against diesel exhaust particles-induced cardiovascular oxidative stress and inflammation in Wistar rats. Environmental science and pollution research international. 2022 Jul; 29(35):52574-52589. doi: 10.1007/s11356-022-19494-3. [PMID: 35262885]
  • Tatianny de Araújo Andrade, Luana Heimfarth, Danillo Menezes Dos Santos, Márcio Roberto Viana Dos Santos, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Agenor Gomes Dos Santos-Neto, Guilherme Rodolfo Souza de Araujo, Ana Amélia Moreira Lira, Saulo Santos Matos, Luiza Abrahão Frank, Thallita Kelly Rabelo, Lucindo José Quintans-Júnior, Jullyana de Souza Siqueira Quintans, Adriano Antunes de Souza Araujo, Mairim Russo Serafini. Hesperetin-Based Hydrogels Protect the Skin against UV Radiation-Induced Damage. AAPS PharmSciTech. 2022 Jun; 23(6):170. doi: 10.1208/s12249-022-02323-8. [PMID: 35729366]
  • Yaseen Hussain, Haroon Khan, Thomas Efferth, Waqas Alam. Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jun; 100(?):153985. doi: 10.1016/j.phymed.2022.153985. [PMID: 35358935]
  • Heba M Abdou, Fatma A Hamaad, Esraa Y Ali, Mamdooh H Ghoneum. Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 May; 149(?):112838. doi: 10.1016/j.biopha.2022.112838. [PMID: 35344738]
  • Juan-Juan Li, Xin-Yi Lu, Pengcheng Jia, Lin Zhu, Ao Wang, Fang-Tian Bu, Yi-Long Zhang, Cheng Huang, Jun Li. O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway. Toxicology. 2022 01; 466(?):153087. doi: 10.1016/j.tox.2021.153087. [PMID: 34974135]
  • Heba Mohamed Abdou, Heba-Tallah Abd Elrahim Abd Elkader. The potential therapeutic effects of Trifolium alexandrinum extract, hesperetin and quercetin against diabetic nephropathy via attenuation of oxidative stress, inflammation, GSK-3β and apoptosis in male rats. Chemico-biological interactions. 2022 Jan; 352(?):109781. doi: 10.1016/j.cbi.2021.109781. [PMID: 34922902]
  • Ahmet Tektemur, Nalan Kaya Tektemur, Elif Erdem Güzel. The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1). Toxicology and applied pharmacology. 2022 01; 435(?):115833. doi: 10.1016/j.taap.2021.115833. [PMID: 34933056]
  • Qian Lu, Yongwei Lai, Hong Zhang, Kuang Ren, Wei Liu, Ying An, Jiahong Yao, Hongyan Fan. Hesperetin Inhibits TGF-β1-Induced Migration and Invasion of Triple Negative Breast Cancer MDA-MB-231 Cells via Suppressing Fyn/Paxillin/RhoA Pathway. Integrative cancer therapies. 2022 Jan; 21(?):15347354221086900. doi: 10.1177/15347354221086900. [PMID: 35297710]
  • Bahare Salehi, Natália Cruz-Martins, Monica Butnariu, Ioan Sarac, Iulia-Cristina Bagiu, Shahira M Ezzat, Jinfan Wang, Aaron Koay, Helen Sheridan, Charles Oluwaseun Adetunji, Prabhakar Semwal, Mauricio Schoebitz, Miquel Martorell, Javad Sharifi-Rad. Hesperetin's health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations. Critical reviews in food science and nutrition. 2022; 62(16):4449-4464. doi: 10.1080/10408398.2021.1875979. [PMID: 33491467]
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