1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (BioDeep_00000003465)
Secondary id: BioDeep_00001868301
human metabolite blood metabolite
代谢物信息卡片
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
化学式: C12H15N (173.120443)
中文名称: 1-甲基-4-苯基-1,2,3,6-四氢吡啶
谱图信息:
最多检出来源 Homo sapiens(bile_acids) 2.04%
分子结构信息
SMILES: CN(C2)CC=C(C2)c(c1)cccc1
InChI: InChI=1S/C12H15N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-7H,8-10H2,1H3
描述信息
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D009676 - Noxae > D009498 - Neurotoxins
KEIO_ID M034
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:17963
- KEGG: C04599
- PubChem: 1388
- HMDB: HMDB0243929
- Metlin: METLIN66221
- ChEMBL: CHEMBL24172
- Wikipedia: MPTP
- MeSH: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- chemspider: 1346
- CAS: 28289-54-5
- MoNA: KO003386
- MoNA: KO003383
- MoNA: KO003382
- MoNA: KO003385
- MoNA: KO003384
- PMhub: MS000009717
- PubChem: 7196
- NIKKAJI: J22.909A
- RefMet: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xian-Zhe Fan, Jia-Qi Song, Xin-Yi Shi, Jin-Fang Zhou, Rui-Juan Yuan, Ting Liu, Xiang-Qian Kong, Ya-Si Huang, Li-Jun Zhang, Hai-Bing Liao. New sesquiterpenoids with neuroprotective effects in vitro and in vivo from the Picrasma chinensis.
Fitoterapia.
2024 Jun; 175(?):105908. doi:
10.1016/j.fitote.2024.105908. [PMID: 38479621] - Ziliang He, Yeye Hu, Ying Zhang, Jing Xie, Zhiqiang Niu, Guigui Yang, Ji Zhang, Zixuan Zhao, Shuai Wei, Haifeng Wu, Weicheng Hu. Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 May; 127(?):155494. doi:
10.1016/j.phymed.2024.155494. [PMID: 38471370] - Wenping Yang, Yongyue Wei, Jin Sun, Caixia Yao, Fen Ai, Haixia Ding. Safranal exerts a neuroprotective effect on Parkinson's disease with suppression of NLRP3 inflammation activation.
Molecular biology reports.
2024 Apr; 51(1):593. doi:
10.1007/s11033-024-09537-y. [PMID: 38683404] - J Gui, X Sun, S Wen, X Liu, B Qin, M Sang. [Resveratrol protects dopaminergic neurons in a mouse model of Parkinson's disease by regulating the gut-brain axis via inhibiting the TLR4 signaling pathway].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2024 Feb; 44(2):270-279. doi:
10.12122/j.issn.1673-4254.2024.02.09. [PMID: 38501412] - Li Liu, Lei Jiang, Jinglan Zhang, Yan Ma, Min Wan, Xueqing Hu, Lian Yang. Imperatorin inhibits oxidative stress injury and neuroinflammation via the PI3K/AKT signaling pathway in the MPTP-induced Parkinson's disease mouse.
Neuroreport.
2024 Feb; 35(3):175-184. doi:
10.1097/wnr.0000000000001997. [PMID: 38305108] - Jiahua Huang, Xinyue Zhang, Xueping Yang, Qingyun Yv, Fanlong Ye, Sheng Chen, Ying Cui, Linting Gu, Min Zhu, Wenwei Li. Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease.
Chemico-biological interactions.
2024 Jan; 387(?):110820. doi:
10.1016/j.cbi.2023.110820. [PMID: 38016618] - Yuan Gao, Jiang Liu, Xiaoyan Wang, Qiang Meng. Vanillin attenuates oxidative stress and neurochemical balance in MPTP-induced Parkinson's disease mice by regulating the TLR-4 inflammatory pathway.
Folia neuropathologica.
2024 Jan; ?(?):. doi:
10.5114/fn.2023.131191. [PMID: 38174675] - Bo Niu, Minhong Zhao, Xiu'an Gao, Jiangping Xu, Linzhong Yu. TMT-based quantitative proteomics analysis of neuroprotective effects of Forsythoside A on the MPTP-induced Parkinson's disease mouse model.
Experimental neurology.
2023 Dec; 373(?):114642. doi:
10.1016/j.expneurol.2023.114642. [PMID: 38056584] - Eduarda Monteiro Fidelis, Anne Suely P Savall, Jhuly Dornelles Mello, Caroline Brandão Quines, Antônio Alvenir Comis-Neto, Tuane Bazanella Sampaio, Cristiane Casagrande Denardin, Daiana Silva de Ávila, Suzan Gonçalves Rosa, Simone Pinton. Purple pitanga extract (Eugenia uniflora) attenuates oxidative stress induced by MPTP.
Metabolic brain disease.
2023 12; 38(8):2615-2625. doi:
10.1007/s11011-023-01318-z. [PMID: 37921949] - Hong-Yan Li, De-Shui Liu, Li-Bo Li, Ying-Bo Zhang, Hai-Ying Dong, Hua Rong, Jing-Yan Zhang, Jun-Ping Wang, Ming Jin, Nan Luo, Xiao-Jie Zhang. Total Glucosides of White Paeony Capsule ameliorates Parkinson's disease-like behavior in MPTP-induced mice model by regulating LRRK2/alpha-synuclein signaling.
Journal of ethnopharmacology.
2023 Oct; ?(?):117319. doi:
10.1016/j.jep.2023.117319. [PMID: 37838295] - Sai Teja Meka, Sree Lalitha Bojja, Gautam Kumar, Sumit Raosaheb Birangal, C Mallikarjuna Rao. Novel HDAC inhibitors provide neuroprotection in MPTP-induced Parkinson's disease model of rats.
European journal of pharmacology.
2023 Sep; 959(?):176067. doi:
10.1016/j.ejphar.2023.176067. [PMID: 37751833] - Xinran Guo, Yuhan Wu, Qingqing Wang, Jianbing Zhang, Xueping Sheng, Lanrong Zheng, Yule Wang. Huperzine A injection ameliorates motor and cognitive abnormalities via regulating multiple pathways in a murine model of Parkinson's disease.
European journal of pharmacology.
2023 Aug; ?(?):175970. doi:
10.1016/j.ejphar.2023.175970. [PMID: 37549727] - Zhengjia Pu, Shuya Liu, Zeming Guo, Xuemei Zhang, Jie Yan, Yong Tang, Hong Xiao, Jieying Gao, Yingli Li, Qunhua Bai. Casein Reactivates Dopaminergic Nerve Injury and Intestinal Inflammation with Disturbing Intestinal Microflora and Fecal Metabolites in a Convalescent Parkinson's Disease Mouse Model.
Neuroscience.
2023 08; 524(?):120-136. doi:
10.1016/j.neuroscience.2023.05.014. [PMID: 37321369] - Tao Pan, Qi Xiao, Hui-Jie Fan, Lei Xu, Shao-Chen Qin, Li-Xia Yang, Xiao-Ming Jin, Bao-Guo Xiao, Bo Zhang, Cun-Gen Ma, Zhi Chai. Wuzi Yanzong Pill relieves MPTP-induced motor dysfunction and neuron loss by inhibiting NLRP3 inflammasome-mediated neuroinflammation.
Metabolic brain disease.
2023 Jul; ?(?):. doi:
10.1007/s11011-023-01266-8. [PMID: 37470879] - Ziying Wang, Jinshuai Cui, Dongni Li, Shuzhen Ran, Junqing Huang, Gang Chen. Morin exhibits a neuroprotective effect in MPTP-induced Parkinson's disease model via TFEB/AMPK-mediated mitophagy.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 May; 116(?):154866. doi:
10.1016/j.phymed.2023.154866. [PMID: 37209604] - María Dolores García-Fernández, Ane Larrea, Roberto Fernández, Rafael Rodríguez-Puertas, Egoitz Astigarraga, Iván Manuel, Gabriel Barreda-Gómez. Microarrays, Enzymatic Assays, and MALDI-MS for Determining Specific Alterations to Mitochondrial Electron Transport Chain Activity, ROS Formation, and Lipid Composition in a Monkey Model of Parkinson's Disease.
International journal of molecular sciences.
2023 Mar; 24(6):. doi:
10.3390/ijms24065470. [PMID: 36982541] - Hongwei Cai, Pei Zhang, Tongxia Li, Ming Li, Lijun Zhang, Chi Cui, Jie Lei, Jian Yang, Kun Ren, Jie Ming, Bo Tian. Amygdalo-nigral circuit mediates stress-induced vulnerability to the parkinsonian toxin MPTP.
CNS neuroscience & therapeutics.
2023 Mar; ?(?):. doi:
10.1111/cns.14151. [PMID: 36914579] - Sarah Martins Presti-Silva, Alice Laschuk Herlinger, Cristina Martins-Silva, Rita Gomes Wanderley Pires. Biochemical and behavioral effects of rosmarinic acid treatment in an animal model of Parkinson's disease induced by MPTP.
Behavioural brain research.
2023 Feb; 440(?):114257. doi:
10.1016/j.bbr.2022.114257. [PMID: 36526017] - I O Ishola, A K Oloyo, T G Olubodun-Obadun, O D Godswill, S A Omilabu, O O Adeyemi. Neuroprotective potential of plant derived parenchymal stem cells extract on environmental and genetic models of Parkinson disease through attenuation of oxidative stress and neuroinflammation.
Metabolic brain disease.
2023 Feb; 38(2):557-571. doi:
10.1007/s11011-022-01120-3. [PMID: 36401682] - Wenda Zhu, Yiping Fan, Yanbing Li, Lizhi Peng, Yifang Li, Fengxia Yan, Jiaqiang Zhao, Lei Zhang, Hiroshi Kurihara, Rongrong He, Heru Chen. Hybridization of amantadine with gardenamide A enhances NMDA antagonism and in vivo anti-PD effects.
Bioorganic chemistry.
2023 01; 130(?):106223. doi:
10.1016/j.bioorg.2022.106223. [PMID: 36356372] - Yiru Ding, Meiyu Zhou, Ruoyin Zheng, Ruijia Ma, Jialin Deng, Wen-Zhi Hao, Lu Wang, Ji-Chun Zhang, Chi-Tang Ho, Jun-Qing Huang. Feruloylated oligosaccharides ameliorate MPTP-induced neurotoxicity in mice by activating ERK/CREB/BDNF/TrkB signalling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 108(?):154512. doi:
10.1016/j.phymed.2022.154512. [PMID: 36288652] - Adeola Oluwatosin Adedara, Guilherme Wildner, Julia Sepel Loreto, Matheus Mulling Dos Santos, Amos Olalekan Abolaji, Nilda Vargas Barbosa. Kaempferol counteracts toxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in D. melanogaster: An implication of its mitoprotective activity.
Neurotoxicology.
2022 Dec; 95(?):23-34. doi:
10.1016/j.neuro.2022.12.008. [PMID: 36592898] - Xing-Jie Xu, Tao Pan, Hui-Jie Fan, Xu Wang, Jie-Zhong Yu, Hai-Fei Zhang, Bao-Guo Xiao, Zhen-Yu Li, Bo Zhang, Cun-Gen Ma, Zhi Chai. Neuroprotective effect of hyperoside in MPP+/MPTP -induced dopaminergic neurodegeneration.
Metabolic brain disease.
2022 Dec; ?(?):. doi:
10.1007/s11011-022-01153-8. [PMID: 36576692] - Derya Cansız, Unsal Veli Ustundag, Ismail Unal, A Ata Alturfan, Ebru Emekli-Alturfan. Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity.
Drug and chemical toxicology.
2022 Nov; 45(6):2439-2447. doi:
10.1080/01480545.2021.1957558. [PMID: 34340603] - Samaresh Pal Roy, Sunil Kumar Kadiri, Vipulkumar V Karkar, Srinivasa Rao Konijeti. Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates.
Annales pharmaceutiques francaises.
2022 Nov; 80(6):853-863. doi:
10.1016/j.pharma.2022.02.007. [PMID: 35240121] - Yuhan Wu, Hao Liu, Yule Wang, Hongda Sheng, Zhilin Chen, Dejin Xun, Huimin Wu, Shun Xiao, Yong Bi, Yi Wang. DiHuangYin decoction protects dopaminergic neurons in a Parkinson's disease model by alleviating peripheral inflammation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Oct; 105(?):154357. doi:
10.1016/j.phymed.2022.154357. [PMID: 35933898] - Urmi Vora, Vivek Kumar Vyas, Pranay Wal, Bhagawati Saxena. Effects of eugenol on the behavioral and pathological progression in the MPTP-induced Parkinson's disease mouse model.
Drug discoveries & therapeutics.
2022 Sep; 16(4):154-163. doi:
10.5582/ddt.2022.01026. [PMID: 36002316] - Li-Kung Wu, Surbhi Agarwal, Chia-Hua Kuo, Yen-Lun Kung, Cecilia Hsuan Day, Pi-Yu Lin, Shinn-Zong Lin, Dennis Jine-Yuan Hsieh, Chih-Yang Huang, Chien-Yi Chiang. Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Sep; 104(?):154250. doi:
10.1016/j.phymed.2022.154250. [PMID: 35752074] - Lei Wang, Xinghong Wu, Ge Yang, Nan Hu, Zijian Zhao, Lei Zhao, Shengyu Li. Cannabidiol Alleviates the Damage to Dopaminergic Neurons in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease Mice Via Regulating Neuronal Apoptosis and Neuroinflammation.
Neuroscience.
2022 08; 498(?):64-72. doi:
10.1016/j.neuroscience.2022.06.036. [PMID: 35792194] - Francesca Palese, Silvia Pontis, Natalia Realini, Alexa Torrens, Faizy Ahmed, Francesca Assogna, Clelia Pellicano, Paola Bossù, Gianfranco Spalletta, Kim Green, Daniele Piomelli. Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonism.
Pharmacological research.
2022 08; 182(?):106338. doi:
10.1016/j.phrs.2022.106338. [PMID: 35781057] - José Luis Téllez-Arreola, Ataúlfo Martínez-Torres, Adriana E Flores-Moran, José M Lazaro-Guevara, Argel Estrada-Mondragón. Analysis of the MCTP Amino Acid Sequence Reveals the Conservation of Putative Calcium- and Lipid-Binding Pockets Within the C2 Domains In Silico.
Journal of molecular evolution.
2022 08; 90(3-4):271-282. doi:
10.1007/s00239-022-10057-1. [PMID: 35604448] - Richard J Smeyne, Jeffrey B Eells, Debotri Chatterjee, Matthew Byrne, Shaw M Akula, Srinivas Sriramula, Dorcas P O'Rourke, Peter Schmidt. COVID-19 Infection Enhances Susceptibility to Oxidative Stress-Induced Parkinsonism.
Movement disorders : official journal of the Movement Disorder Society.
2022 Jul; 37(7):1394-1404. doi:
10.1002/mds.29116. [PMID: 35579496] - Qingyu Ren, Xin Jiang, Yam Nath Paudel, Xin Gao, Daili Gao, Pengyu Zhang, Wenlong Sheng, Xueliang Shang, Kechun Liu, Xiujun Zhang, Meng Jin. Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish.
Journal of ethnopharmacology.
2022 Jun; 292(?):115234. doi:
10.1016/j.jep.2022.115234. [PMID: 35358621] - Xiaojuan Han, Yuan Liu, Yan Dai, Tianshu Xu, Qinghui Hu, Xiaolan Yi, Liangyou Rui, Gang Hu, Jun Hu. Neuronal SH2B1 attenuates apoptosis in an MPTP mouse model of Parkinson's disease via promoting PLIN4 degradation.
Redox biology.
2022 06; 52(?):102308. doi:
10.1016/j.redox.2022.102308. [PMID: 35390677] - Wei Hang, Hui-Jie Fan, Yan-Rong Li, Qi Xiao, Lu Jia, Li-Juan Song, Yao Gao, Xiao-Ming Jin, Bao-Guo Xiao, Jie-Zhong Yu, Cun-Gen Ma, Zhi Chai. Wuzi Yanzong pill attenuates MPTP-induced Parkinson's Disease via PI3K/Akt signaling pathway.
Metabolic brain disease.
2022 06; 37(5):1435-1450. doi:
10.1007/s11011-022-00993-8. [PMID: 35488941] - Tingting Zuo, Mo Xie, Meiling Yan, Zengyan Zhang, Tian Tian, Ying Zhu, Lihua Wang, Yanhong Sun. In situ analysis of acupuncture protecting dopaminergic neurons from lipid peroxidative damage in mice of Parkinson's disease.
Cell proliferation.
2022 Apr; 55(4):e13213. doi:
10.1111/cpr.13213. [PMID: 35274781] - Shan Dongjie, R Samuel Rajendran, Qing Xia, Gaimei She, Pengfei Tu, Yun Zhang, Kechun Liu. Neuroprotective effects of Tongtian oral liquid, a Traditional Chinese Medicine in the Parkinson's disease-induced zebrafish model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Apr; 148(?):112706. doi:
10.1016/j.biopha.2022.112706. [PMID: 35152046] - De-Ling Wu, Tong-Sheng Wang, Hong-Juan Liu, Wei Zhang, Xiao-Hui Tong, Dai-Yin Peng, Ling-Yi Kong. Study on the mechanism of Wuzi-Yanzong-Wan-medicated serum interfering with the mitochondrial permeability transition pore in the GC-2 cell induced by atractyloside.
Chinese journal of natural medicines.
2022 Apr; 20(4):282-289. doi:
10.1016/s1875-5364(22)60153-5. [PMID: 35487598] - Hongli Li, Fei Wang, Zhenyu Zhou, Xi Jiang, Fei Li, Yaru Feng, Chuhe Liu, Yu Zhang, Shengjie Fan, Xiaojun Wu, Cheng Huang. Atractylon, a novel dopamine 2 receptor agonist, ameliorates Parkinsonian like motor dysfunctions in MPTP-induced mice.
Neurotoxicology.
2022 03; 89(?):121-126. doi:
10.1016/j.neuro.2022.01.010. [PMID: 35104500] - Cheng-Peng Sun, Jun-Jun Zhou, Zhen-Long Yu, Xiao-Kui Huo, Juan Zhang, Christophe Morisseau, Bruce D Hammock, Xiao-Chi Ma. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model.
Proceedings of the National Academy of Sciences of the United States of America.
2022 03; 119(9):. doi:
10.1073/pnas.2118818119. [PMID: 35217618] - Zhi-Hao Lin, Yi Liu, Nai-Jia Xue, Ran Zheng, Yi-Qun Yan, Zhong-Xuan Wang, Yao-Lin Li, Chang-Zhou Ying, Zhe Song, Jun Tian, Jia-Li Pu, Bao-Rong Zhang. Quercetin Protects against MPP+/MPTP-Induced Dopaminergic Neuron Death in Parkinson's Disease by Inhibiting Ferroptosis.
Oxidative medicine and cellular longevity.
2022; 2022(?):7769355. doi:
10.1155/2022/7769355. [PMID: 36105483] - Kai Wang, Cai Lu, Tong Wang, Chen Qiao, Linyu Lu, Die Wu, Ming Lu, Ruini Chen, Lu Fan, Juanjuan Tang. Hyperoside suppresses NLRP3 inflammasome in Parkinson's disease via Pituitary Adenylate Cyclase-Activating Polypeptide.
Neurochemistry international.
2022 01; 152(?):105254. doi:
10.1016/j.neuint.2021.105254. [PMID: 34883151] - Jing Gao, Wenxin Zhang, Xueqing Chai, Xiaoyue Tan, Zhuo Yang. Asparagine endopeptidase deletion ameliorates cognitive impairments by inhibiting proinflammatory microglial activation in MPTP mouse model of Parkinson disease.
Brain research bulletin.
2022 01; 178(?):120-130. doi:
10.1016/j.brainresbull.2021.11.011. [PMID: 34838642] - Qingxin Song, Shanxin Peng, Xiaosong Zhu. Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease.
Neurotoxicology.
2021 12; 87(?):188-194. doi:
10.1016/j.neuro.2021.10.003. [PMID: 34666128] - Jiajing Shan, Youge Qu, Siming Wang, Yan Wei, Lijia Chang, Li Ma, Kenji Hashimoto. Regulation of neurotoxicity in the striatum and colon of MPTP-induced Parkinson's disease mice by gut microbiome.
Brain research bulletin.
2021 12; 177(?):103-110. doi:
10.1016/j.brainresbull.2021.09.009. [PMID: 34560239] - Imane Frouni, Sébastien Belliveau, Shawn Maddaford, Stephen G Nuara, Jim C Gourdon, Philippe Huot. Effect of the glycine transporter 1 inhibitor ALX-5407 on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.
European journal of pharmacology.
2021 Nov; 910(?):174452. doi:
10.1016/j.ejphar.2021.174452. [PMID: 34480885] - Xiaochen Bai, Xiaoshuang Zhang, Rong Fang, Jinghui Wang, Yuanyuan Ma, Zhaolin Liu, Hongtian Dong, Qing Li, Jingyu Ge, Mei Yu, Jian Fei, Ruilin Sun, Fang Huang. Deficiency of miR-29b2/c leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice.
Aging.
2021 09; 13(18):22390-22411. doi:
10.18632/aging.203545. [PMID: 34543233] - Cong Liu, Wenjuan Wang, Hao Li, Jiangang Liu, Peng Zhang, Yong Cheng, Xiaoyan Qin, Yang Hu, Yun Wei. The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease.
Food & function.
2021 Jul; 12(13):6091-6101. doi:
10.1039/d1fo00843a. [PMID: 34047315] - Mai Wada, Mary Jasmin Ang, Poornima D E Weerasinghe-Mudiyanselage, Sung-Ho Kim, Jong-Choon Kim, Taekyun Shin, Changjong Moon. Behavioral characterization in MPTP/p mouse model of Parkinson's disease.
Journal of integrative neuroscience.
2021 Jun; 20(2):307-320. doi:
10.31083/j.jin2002030. [PMID: 34258929] - Xiang-Li Ning, Yu-Zhi Li, Cui Huo, Ji Deng, Cheng Gao, Kai-Rong Zhu, Miao Wang, Yu-Xiang Wu, Jun-Lin Yu, Ya-Li Ren, Zong-Yuan Luo, Gen Li, Yang Chen, Si-Yao Wang, Cheng Peng, Ling-Ling Yang, Zhou-Yu Wang, Yong Wu, Shan Qian, Guo-Bo Li. X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Journal of medicinal chemistry.
2021 06; 64(12):8303-8332. doi:
10.1021/acs.jmedchem.1c00303. [PMID: 34110158] - Joong-Sun Kim, Hye-Sun Lim, Byeong-Cheol Moon, Mary-Jasmin Ang, Sung-Ho Kim, Chang-Jong Moon, Boseok Seong, Yun-Ji Jang, Hyung-Yong Kim, Chul Kim. Epigenetic mechanisms involved in the neuroprotective effect of scorpion extract in a Parkinson's disease murine model based on multi-omics approach.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2021 06; 41(3):390-396. doi:
10.19852/j.cnki.jtcm.2021.03.007. [PMID: 34114396] - Xinrong Liu, Shuya Liu, Yong Tang, Zhengjia Pu, Hong Xiao, Jieying Gao, Qi Yin, Yan Jia, Qunhua Bai. Intragastric Administration of Casein Leads to Nigrostriatal Disease Progressed Accompanied with Persistent Nigrostriatal-Intestinal Inflammation Activited and Intestinal Microbiota-Metabolic Disorders Induced in MPTP Mouse Model of Parkinson's Disease.
Neurochemical research.
2021 Jun; 46(6):1514-1539. doi:
10.1007/s11064-021-03293-2. [PMID: 33719004] - Hong-Qiu Zhang, Jian-Yong Wang, Zhao-Feng Li, Lei Cui, Shi-Shi Huang, Lan-Bing Zhu, Yue Sun, Rui Yang, Hui-Hui Fan, Xiong Zhang, Jian-Hong Zhu. DNA Methyltransferase 1 Is Dysregulated in Parkinson's Disease via Mediation of miR-17.
Molecular neurobiology.
2021 Jun; 58(6):2620-2633. doi:
10.1007/s12035-021-02298-w. [PMID: 33483902] - Rachel M McQuade, Lewis M Singleton, Hongyi Wu, Sophie Lee, Remy Constable, Madeleine Di Natale, Mitchell T Ringuet, Joel P Berger, Jessica Kauhausen, Clare L Parish, David I Finkelstein, John B Furness, Shanti Diwakarla. The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease.
Scientific reports.
2021 04; 11(1):7934. doi:
10.1038/s41598-021-86917-5. [PMID: 33846426] - Yu-Lin Guo, Wen-Jun Duan, Dan-Hua Lu, Xiao-Hui Ma, Xiao-Xiao Li, Zhao Li, Wei Bi, Hiroshi Kurihara, Hai-Zhi Liu, Yi-Fang Li, Rong-Rong He. Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson's disease.
Acta pharmacologica Sinica.
2021 Apr; 42(4):518-528. doi:
10.1038/s41401-020-0454-y. [PMID: 32724177] - Shrook A Mohamed, Dalia H El-Kashef, Manar A Nader. Tiron alleviates MPTP-induced Parkinsonism in mice via activation of Keap-1/Nrf2 pathway.
Journal of biochemical and molecular toxicology.
2021 Mar; 35(3):e22685. doi:
10.1002/jbt.22685. [PMID: 33368846] - Dong Yue, Chaorong Zeng, Samuel Kumi Okyere, Zhengli Chen, Yanchun Hu. Glycine nano-selenium prevents brain oxidative stress and neurobehavioral abnormalities caused by MPTP in rats.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2021 Mar; 64(?):126680. doi:
10.1016/j.jtemb.2020.126680. [PMID: 33242795] - Guifang Zhang, Lishi Yin, Zhenchun Luo, Xuemei Chen, Yanping He, Xie Yu, Ming Wang, Fengwei Tian, Haiyan Luo. Effects and potential mechanisms of rapamycin on MPTP-induced acute Parkinson's disease in mice.
Annals of palliative medicine.
2021 Mar; 10(3):2889-2897. doi:
10.21037/apm-20-1096. [PMID: 33549024] - Maria João Bonifácio, Filipa Sousa, Patrício Soares-da-Silva. Opicapone enhances the reversal of MPTP-induced Parkinson-like syndrome by levodopa in cynomolgus monkeys.
European journal of pharmacology.
2021 Feb; 892(?):173742. doi:
10.1016/j.ejphar.2020.173742. [PMID: 33220276] - Hongli Li, Yaru Feng, Ziyu Chen, Xi Jiang, Zhenyu Zhou, Jinfeng Yuan, Fei Li, Yu Zhang, Xingxu Huang, Shengjie Fan, Xiaojun Wu, Cheng Huang. Pepper component 7-ethoxy-4-methylcoumarin, a novel dopamine D2 receptor agonist, ameliorates experimental Parkinson's disease in mice and Caenorhabditis elegans.
Pharmacological research.
2021 01; 163(?):105220. doi:
10.1016/j.phrs.2020.105220. [PMID: 33007422] - Hyongjun Jeon, Hee-Young Kim, Chang-Hwan Bae, Yukyoung Lee, Seungtae Kim. Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model.
Journal of medicinal food.
2020 Dec; 23(12):1231-1237. doi:
10.1089/jmf.2019.4640. [PMID: 33121350] - Shichao Huang, Yu'e Liu, Yanan Zhang, Ru Zhang, ChengJie Zhu, Lihong Fan, Gang Pei, Bo Zhang, Yufeng Shi. Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner.
Signal transduction and targeted therapy.
2020 11; 5(1):266. doi:
10.1038/s41392-020-00353-x. [PMID: 33188163] - Mustafa T Ardah, Greeshma Bharathan, Tohru Kitada, M Emdadul Haque. Ellagic Acid Prevents Dopamine Neuron Degeneration from Oxidative Stress and Neuroinflammation in MPTP Model of Parkinson's Disease.
Biomolecules.
2020 11; 10(11):. doi:
10.3390/biom10111519. [PMID: 33172035] - Valerie Joers, Gunasingh Masilamoni, Doty Kempf, Alison R Weiss, Travis M Rotterman, Benjamin Murray, Gul Yalcin-Cakmakli, Ronald J Voll, Mark M Goodman, Leonard Howell, Jocelyne Bachevalier, Stefan J Green, Ankur Naqib, Maliha Shaikh, Phillip A Engen, Ali Keshavarzian, Christopher J Barnum, Jonathon A Nye, Yoland Smith, Malú G Tansey. Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series.
Neurobiology of disease.
2020 10; 144(?):105027. doi:
10.1016/j.nbd.2020.105027. [PMID: 32712266] - Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Yunfei Tan, Xingming Wang, Jiancheng Zhang, Kenji Hashimoto. Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP.
Neuroscience letters.
2020 06; 730(?):135032. doi:
10.1016/j.neulet.2020.135032. [PMID: 32387710] - An-Ling Hu, Sheng Song, Yi Li, Shang-Fu Xu, Feng Zhang, Cen Li, Jie Liu. Mercury sulfide-containing Hua-Feng-Dan and 70W (Rannasangpei) protect against LPS plus MPTP-induced neurotoxicity and disturbance of gut microbiota in mice.
Journal of ethnopharmacology.
2020 May; 254(?):112674. doi:
10.1016/j.jep.2020.112674. [PMID: 32105745] - Qianqian Liu, Xinyang Guo, Ziwei Huang, Qiujia He, Dashuai Zhu, Shaozhi Zhang, Ziwei Peng, Yongzhe Che, Xizeng Feng. Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice.
Behavioural brain research.
2020 04; 383(?):112539. doi:
10.1016/j.bbr.2020.112539. [PMID: 32032741] - Atsuhiro Fujita, Yuko Fujita, Yaoyu Pu, Lijia Chang, Kenji Hashimoto. MPTP-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (R)-ketamine: a role of TrkB signaling.
Psychopharmacology.
2020 Jan; 237(1):83-92. doi:
10.1007/s00213-019-05346-5. [PMID: 31418048] - Mo Xu, Jerry K Bohlen, Cynthia Moore, Michelle A Nipper, Deborah A Finn, Carolyn E Jones, Miranda M Lim, Charles K Meshul. Effects of sleep disruption on stress, nigrostriatal markers, and behavior in a chronic/progressive MPTP male mouse model of parkinsonism.
Journal of neuroscience research.
2019 12; 97(12):1706-1719. doi:
10.1002/jnr.24520. [PMID: 31535395] - Mia San Miguel, Kristy L Martin, Jonathan Stone, Daniel M Johnstone. Photobiomodulation Mitigates Cerebrovascular Leakage Induced by the Parkinsonian Neurotoxin MPTP.
Biomolecules.
2019 10; 9(10):. doi:
10.3390/biom9100564. [PMID: 31590236] - Xin-Fang Wu, Leng-Xin Duan, Xiao-le Gao, Man-Lin Guo, Dong-Mei Wang. [Study on preventive and therapeutic effects of Erzhi Pills on mice with Parkinson's disease induced by MPTP].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2019 Oct; 44(19):4219-4224. doi:
10.19540/j.cnki.cjcmm.20190603.405. [PMID: 31872702] - Philip Carella. Moving on Up: An MCTP-SNARE Complex Mediates Long-Distance Florigen Transport.
The Plant cell.
2019 10; 31(10):2293-2294. doi:
10.1105/tpc.1900664. [PMID: 31594832] - Liyue Qin, Ziyu Chen, Liu Yang, Hailian Shi, Hui Wu, Beibei Zhang, Weiqi Zhang, Qi Xu, Fei Huang, Xiaojun Wu. Luteolin-7-O-glucoside protects dopaminergic neurons by activating estrogen-receptor-mediated signaling pathway in MPTP-induced mice.
Toxicology.
2019 10; 426(?):152256. doi:
10.1016/j.tox.2019.152256. [PMID: 31381935] - Elena Chiricozzi, Margherita Maggioni, Erika di Biase, Giulia Lunghi, Maria Fazzari, Nicoletta Loberto, Maffioli Elisa, Francesca Grassi Scalvini, Gabriella Tedeschi, Sandro Sonnino. The Neuroprotective Role of the GM1 Oligosaccharide, II3Neu5Ac-Gg4, in Neuroblastoma Cells.
Molecular neurobiology.
2019 Oct; 56(10):6673-6702. doi:
10.1007/s12035-019-1556-8. [PMID: 30911934] - Sachchida Nand Rai, Walia Zahra, Saumitra Sen Singh, Hareram Birla, Chetan Keswani, Hagera Dilnashin, Aaina Singh Rathore, Rajan Singh, Rakesh K Singh, Surya Pratap Singh. Anti-inflammatory Activity of Ursolic Acid in MPTP-Induced Parkinsonian Mouse Model.
Neurotoxicity research.
2019 Oct; 36(3):452-462. doi:
10.1007/s12640-019-00038-6. [PMID: 31016688] - Weitong Cui, Yuxi Zhan, Xiaoru Shao, Wei Fu, Dexuan Xiao, Junyao Zhu, Xin Qin, Tianyi Zhang, Mei Zhang, Yi Zhou, Yunfeng Lin. Neuroprotective and Neurotherapeutic Effects of Tetrahedral Framework Nucleic Acids on Parkinson's Disease in Vitro.
ACS applied materials & interfaces.
2019 Sep; 11(36):32787-32797. doi:
10.1021/acsami.9b10308. [PMID: 31424187] - Berhanu Geresu, Ana Canseco-Alba, Branden Sanabria, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaivi, Ephrem Engidawork. Involvement of CB2 Receptors in the Neurobehavioral Effects of Catha Edulis (Vahl) Endl. (Khat) in Mice.
Molecules (Basel, Switzerland).
2019 Aug; 24(17):. doi:
10.3390/molecules24173164. [PMID: 31480324] - Yong-Bo Hu, Yong-Fang Zhang, Hao Wang, Ru-Jing Ren, Hai-Lun Cui, Wan-Ying Huang, Qi Cheng, Hong-Zhuan Chen, Gang Wang. miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease.
Cell death & disease.
2019 08; 10(8):589. doi:
10.1038/s41419-019-1809-5. [PMID: 31383850] - Yuyuan Gao, Hongmei Tang, Kun Nie, Ruiming Zhu, Liang Gao, Shujun Feng, Limin Wang, Jiehao Zhao, Zhiheng Huang, Yuhu Zhang, Lijuan Wang. Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion.
Behavioural brain research.
2019 08; 368(?):111885. doi:
10.1016/j.bbr.2019.03.054. [PMID: 30959125] - Susan Burks, James Raymick, Bonnie Robinson, Joseph Hanig, Sumit Sarkar. Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson's disease mouse model: Endothelial and microglial effects.
Neuroscience letters.
2019 06; 703(?):86-95. doi:
10.1016/j.neulet.2019.03.015. [PMID: 30890473] - Mani Sugumar, Murugan Sevanan, Sathiya Sekar. Neuroprotective effect of naringenin against MPTP-induced oxidative stress.
The International journal of neuroscience.
2019 Jun; 129(6):534-539. doi:
10.1080/00207454.2018.1545772. [PMID: 30433834] - Zuobo Wang, Lin Sun, Kaixue Jia, Hongxia Wang, Xiuxiang Wang. miR-9-5p modulates the progression of Parkinson's disease by targeting SIRT1.
Neuroscience letters.
2019 05; 701(?):226-233. doi:
10.1016/j.neulet.2019.02.038. [PMID: 30826419] - Alexander Kim, Razina Nigmatullina, Zuleikha Zalyalova, Natalia Soshnikova, Alexey Krasnov, Nadezhda Vorobyeva, Sofia Georgieva, Vladimir Kudrin, Viktor Narkevich, Michael Ugrumov. Upgraded Methodology for the Development of Early Diagnosis of Parkinson's Disease Based on Searching Blood Markers in Patients and Experimental Models.
Molecular neurobiology.
2019 May; 56(5):3437-3450. doi:
10.1007/s12035-018-1315-2. [PMID: 30128652] - Tom H Johnston, Michal Geva, Lilach Steiner, Aric Orbach, Spyros Papapetropoulos, Juha-Matti Savola, Ian J Reynolds, Paula Ravenscroft, Michael Hill, Susan H Fox, Jonathan M Brotchie, Ralph Laufer, Michael R Hayden. Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.
Movement disorders : official journal of the Movement Disorder Society.
2019 05; 34(5):708-716. doi:
10.1002/mds.27565. [PMID: 30575996] - Xue Xue, Weiwei Zhang, Jifeng Zhu, Xiaojun Chen, Sha Zhou, Zhipeng Xu, Gang Hu, Chuan Su. Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease.
Journal of cellular and molecular medicine.
2019 04; 23(4):2568-2582. doi:
10.1111/jcmm.14147. [PMID: 30680924] - Cynthia Kwan, Imane Frouni, Dominique Bédard, Stephen G Nuara, Jim C Gourdon, Adjia Hamadjida, Philippe Huot. 5-HT2A blockade for dyskinesia and psychosis in Parkinson's disease: is there a limit to the efficacy of this approach? A study in the MPTP-lesioned marmoset and a literature mini-review.
Experimental brain research.
2019 Feb; 237(2):435-442. doi:
10.1007/s00221-018-5434-9. [PMID: 30443669] - Hung-Chi Chang, Keng-Fan Liu, Chia-Jen Teng, Shu-Chen Lai, Shu-Er Yang, Hui Ching, Chi-Rei Wu. Sophora Tomentosa Extract Prevents MPTP-Induced Parkinsonism in C57BL/6 Mice Via the Inhibition of GSK-3β Phosphorylation and Oxidative Stress.
Nutrients.
2019 Jan; 11(2):. doi:
10.3390/nu11020252. [PMID: 30678114] - Shaheen Jafri Ali, Govindraj Ellur, Md Touseef Khan, Kunal Sharan. Bone loss in MPTP mouse model of Parkinson's disease is triggered by decreased osteoblastogenesis and increased osteoclastogenesis.
Toxicology and applied pharmacology.
2019 01; 363(?):154-163. doi:
10.1016/j.taap.2018.12.003. [PMID: 30529163] - Min Gi Jo, Muhammad Ikram, Myeung Hoon Jo, Lang Yoo, Kwang Chul Chung, Seung-Yeol Nah, Hongik Hwang, Hyewhon Rhim, Myeong Ok Kim. Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway.
Molecular neurobiology.
2019 Jan; 56(1):39-55. doi:
10.1007/s12035-018-1020-1. [PMID: 29675576] - Sujung Yeo, Sabina Lim. Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model.
The American journal of Chinese medicine.
2019; 47(3):527-539. doi:
10.1142/s0192415x19500277. [PMID: 30966771] - Marika Cordaro, Rosalba Siracusa, Rosalia Crupi, Daniela Impellizzeri, Alessio Filippo Peritore, Ramona D'Amico, Enrico Gugliandolo, Rosanna Di Paola, Salvatore Cuzzocrea. 2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.
Molecular neurobiology.
2018 Dec; 55(12):9251-9266. doi:
10.1007/s12035-018-1064-2. [PMID: 29656363] - Stephana Carelli, Toniella Giallongo, Zuzana Gombalova, Federica Rey, Maria Carlotta F Gorio, Massimiliano Mazza, Anna Maria Di Giulio. Counteracting neuroinflammation in experimental Parkinson's disease favors recovery of function: effects of Er-NPCs administration.
Journal of neuroinflammation.
2018 Nov; 15(1):333. doi:
10.1186/s12974-018-1375-2. [PMID: 30501635] - Da Hye Song, Gyeong-Ji Kim, Kwon Jai Lee, Jae Soo Shin, Dong-Hee Kim, Byung-Jun Park, Jeung Hee An. Mitigation Effects of a Novel Herbal Medicine, Hepad, on Neuroinflammation, Neuroapoptosis, and Neuro-Oxidation.
Molecules (Basel, Switzerland).
2018 Nov; 23(11):. doi:
10.3390/molecules23112920. [PMID: 30413118] - Rosalia Crupi, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Giovanna Casili, Maurizio Evangelista, Salvatore Cuzzocrea. N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice.
Molecular neurobiology.
2018 Nov; 55(11):8455-8472. doi:
10.1007/s12035-018-0959-2. [PMID: 29552727] - Feng Lai, Rong Jiang, Wenjun Xie, Xinrong Liu, Yong Tang, Hong Xiao, Jieying Gao, Yan Jia, Qunhua Bai. Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson's Disease.
Neurochemical research.
2018 Oct; 43(10):1986-1999. doi:
10.1007/s11064-018-2620-x. [PMID: 30171422] - Joshua I Hardt, Joel S Perlmutter, Christopher J Smith, Kevin L Quick, Ling Wei, Subhasish K Chakraborty, Laura L Dugan. Pharmacokinetics and Toxicology of the Neuroprotective e,e,e-Methanofullerene(60)-63-tris Malonic Acid [C3] in Mice and Primates.
European journal of drug metabolism and pharmacokinetics.
2018 Oct; 43(5):543-554. doi:
10.1007/s13318-018-0464-z. [PMID: 29520718] - Jin Gyu Choi, Eugene Huh, In Gyoung Ju, Namkwon Kim, Jason Yun, Myung Sook Oh. 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine/probenecid impairs intestinal motility and olfaction in the early stages of Parkinson's disease in mice.
Journal of the neurological sciences.
2018 09; 392(?):77-82. doi:
10.1016/j.jns.2018.07.011. [PMID: 30031172] - Atsushi Fujita, Hiroo Yamaguchi, Ryo Yamasaki, Yiwen Cui, Yuta Matsuoka, Ken-Ichi Yamada, Jun-Ichi Kira. Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson's disease animal model.
Journal of neuroinflammation.
2018 Aug; 15(1):227. doi:
10.1186/s12974-018-1251-0. [PMID: 30103794] - Chuwen Li, Benqin Tang, Yu Feng, Fan Tang, Maggie Pui-Man Hoi, Ziren Su, Simon Ming-Yuen Lee. Pinostrobin Exerts Neuroprotective Actions in Neurotoxin-Induced Parkinson's Disease Models through Nrf2 Induction.
Journal of agricultural and food chemistry.
2018 Aug; 66(31):8307-8318. doi:
10.1021/acs.jafc.8b02607. [PMID: 29961319]