15-KETE (BioDeep_00000003303)

Main id: BioDeep_00000628860

 

human metabolite Endogenous blood metabolite


代谢物信息卡片


(5Z,8Z,11Z,13E)-15-Ketoeicosa-5,8,11,13-tetraenoic acid

化学式: C20H30O3 (318.21948299999997)
中文名称: 15-氧代-二十烷四烯酸
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

15-KETE. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/15-kete (retrieved 2024-09-19) (BioDeep RN: BioDeep_00000003303). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCC(=O)/C=C/C=C\C/C=C\C/C=C\CCCC(=O)O
InChI: InChI=1S/C20H30O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)

描述信息

15-OxoETE or 15-KETE is a keto-containing leukotriene derivative produced by oxidation of the 15-hydroxyl of 15-HETE. [HMDB]
15-OxoETE or 15-KETE is a keto-containing leukotriene derivative produced by oxidation of the 15-hydroxyl of 15-HETE.

同义名列表

19 个代谢物同义名

(5Z,8Z,11Z,13E)-15-Ketoeicosa-5,8,11,13-tetraenoic acid; (5Z,8Z,11Z,13E)-15-oxo-5,8,11,13-Eicosatetraenoic acid; (5Z,8Z,11Z,13E)-15-Oxoeicosa-5,8,11,13-tetraenoic acid; (5Z,8Z,11Z,13E)-15-Oxoicosa-5,8,11,13-tetraenoic acid; (5Z,8Z,11Z,13E)-15-Ketoeicosa-5,8,11,13-tetraenoate; (5Z,8Z,11Z,13E)-15-Oxoeicosa-5,8,11,13-tetraenoate; (5Z,8Z,11Z,13E)-15-oxo-5,8,11,13-Eicosatetraenoate; (5Z,8Z,11Z,13E)-15-Oxoicosa-5,8,11,13-tetraenoate; 15-oxo-5,8,11-cis-13-trans-Eicosatetraenoic acid; 15-oxo-5,8,11-cis-13-trans-Icosatetraenoic acid; 15-oxo-5,8,11-cis-13-trans-Eicosatetraenoate; 15-oxo-5,8,11-cis-13-trans-Icosatetraenoate; 15-oxo-5Z,8Z,11Z,13E-eicosatetraenoic acid; 15-Keto-5,8,11,13-eicosatetraenoic acid; 15-oxo-5Z,8Z,11Z,13E-Eicosatetraenoate; 15-KETE (15-oxo-ETE); 15-Oxo-ETE; 15-OxoETE; 15-KETE



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

7 个相关的代谢反应过程信息。

Reactome(5)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Praveen Kumar Sugumaran, Shuang Wang, Shasha Song, Xiaowei Nie, Lei Zhang, Ye Feng, Wenchao Ma, Daling Zhu. 15-oxo-Eicosatetraenoic acid prevents serum deprivation-induced apoptosis of pulmonary arterial smooth muscle cells by activating pro-survival pathway. Prostaglandins, leukotrienes, and essential fatty acids. 2014 Apr; 90(4):89-98. doi: 10.1016/j.plefa.2014.01.006. [PMID: 24534136]
  • Susanna L Lundström, Jun Yang, Henrik J Källberg, Sarah Thunberg, Guro Gafvelin, Jesper Z Haeggström, Reidar Grönneberg, Johan Grunewald, Marianne van Hage, Bruce D Hammock, Anders Eklund, Åsa M Wheelock, Craig E Wheelock. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PloS one. 2012; 7(3):e33780. doi: 10.1371/journal.pone.0033780. [PMID: 22438998]
  • Cong Wei, Peijuan Zhu, Sumit J Shah, Ian A Blair. 15-oxo-Eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation. Molecular pharmacology. 2009 Sep; 76(3):516-25. doi: 10.1124/mol.109.057489. [PMID: 19535459]
  • Seon Hwa Lee, Kannan Rangiah, Michelle V Williams, Angela Y Wehr, Raymond N DuBois, Ian A Blair. Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells. Chemical research in toxicology. 2007 Nov; 20(11):1665-75. doi: 10.1021/tx700130p. [PMID: 17910482]
  • Hui-Chun Yeh, Ah-Lim Tsai, Lee-Ho Wang. Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. Archives of biochemistry and biophysics. 2007 May; 461(2):159-68. doi: 10.1016/j.abb.2007.03.012. [PMID: 17459323]
  • L M Landino, L J Marnett. Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase. Biochemistry. 1996 Feb; 35(8):2637-43. doi: 10.1021/bi952546h. [PMID: 8611568]
  • . . . . doi: . [PMID: 17662651]