Honokiol (BioDeep_00000003230)

Main id: BioDeep_00000017311

 

human metabolite PANOMIX_OTCML-2023 blood metabolite Antitumor activity natural product


代谢物信息卡片


2-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol

化学式: C18H18O2 (266.1307)
中文名称: 和厚朴酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
InChI: InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D005765 - Gastrointestinal Agents
D000890 - Anti-Infective Agents
D000970 - Antineoplastic Agents
D018926 - Anti-Allergic Agents
D004791 - Enzyme Inhibitors
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier[1][2][3][4].
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier[1][2][3][4].
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier[1][2][3][4].

同义名列表

4 个代谢物同义名

2-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol; Honokiol; NSC 293100; Honokiol



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

81 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 ABCB1, AKT1, ANG, CASP3, CDH1, CDK2, EGFR, HSPA5, MAPK14, MTOR, MYC, PIK3CA, PPARG, STAT3, TP53, VEGFA
Peripheral membrane protein 1 MTOR
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 EGFR, HSPA5, MTOR
Nucleus 15 AKT1, ANG, CASP3, CDH1, CDK2, EGFR, HSPA5, MAPK14, MTOR, MYC, PPARA, PPARG, STAT3, TP53, VEGFA
cytosol 12 AKT1, ANG, CASP3, CDH1, CDK2, HSPA5, MAPK14, MTOR, PIK3CA, PPARG, STAT3, TP53
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
trans-Golgi network 1 CDH1
centrosome 2 CDK2, TP53
nucleoplasm 11 AKT1, CASP3, CDH1, CDK2, MAPK14, MTOR, MYC, PPARA, PPARG, STAT3, TP53
RNA polymerase II transcription regulator complex 2 PPARG, STAT3
Cell membrane 5 ABCB1, AKT1, CDH1, EGFR, TNF
Cytoplasmic side 1 MTOR
lamellipodium 3 AKT1, CDH1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 MTOR
cell cortex 1 AKT1
cell junction 2 CDH1, EGFR
cell surface 5 ABCB1, EGFR, HSPA5, TNF, VEGFA
glutamatergic synapse 5 AKT1, CASP3, CDH1, EGFR, MAPK14
Golgi apparatus 2 CDH1, VEGFA
Golgi membrane 3 EGFR, INS, MTOR
growth cone 1 ANG
lysosomal membrane 1 MTOR
neuronal cell body 3 ANG, CASP3, TNF
postsynapse 2 AKT1, CDH1
Lysosome 1 MTOR
endosome 3 CDH1, CDK2, EGFR
plasma membrane 8 ABCB1, AKT1, CDH1, EGFR, HSPA5, PIK3CA, STAT3, TNF
Membrane 9 ABCB1, AKT1, CDH1, EGFR, HSPA5, MTOR, MYC, TP53, VEGFA
apical plasma membrane 2 ABCB1, EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 4 ABCB1, CDH1, HSPA5, SOD2
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 HSPA5, TP53, VEGFA
extracellular space 5 ANG, EGFR, INS, TNF, VEGFA
perinuclear region of cytoplasm 4 CDH1, EGFR, PIK3CA, PPARG
adherens junction 2 CDH1, VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 HSPA5, MAPK14, SOD2, TP53
protein-containing complex 5 AKT1, EGFR, HSPA5, MYC, TP53
intracellular membrane-bounded organelle 2 HSPA5, PPARG
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 CDH1, EGFR
Secreted 3 ANG, INS, VEGFA
extracellular region 6 ANG, CDH1, INS, MAPK14, TNF, VEGFA
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
Mitochondrion matrix 2 SOD2, TP53
mitochondrial matrix 2 SOD2, TP53
transcription regulator complex 3 CDK2, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK2, TP53
nuclear membrane 2 CDH1, EGFR
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 2 ANG, CDH1
microtubule cytoskeleton 1 AKT1
nucleolus 3 ANG, MYC, TP53
midbody 1 HSPA5
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
Membrane raft 2 EGFR, TNF
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 EGFR, HSPA5
spindle 1 AKT1
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
extracellular matrix 1 VEGFA
mitochondrial nucleoid 1 SOD2
basement membrane 1 ANG
intracellular vesicle 1 EGFR
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
lateral plasma membrane 1 CDH1
nuclear speck 1 MAPK14
receptor complex 2 EGFR, PPARG
ciliary basal body 1 AKT1
chromatin 5 MYC, PPARA, PPARG, STAT3, TP53
phagocytic cup 1 TNF
Chromosome 1 ANG
Golgi apparatus, trans-Golgi network 1 CDH1
Nucleus, nucleolus 2 ANG, MYC
spindle pole 1 MAPK14
chromosome, telomeric region 1 CDK2
site of double-strand break 1 TP53
nuclear envelope 3 CDK2, MTOR, MYC
Endomembrane system 1 MTOR
endosome lumen 1 INS
Nucleus, nucleoplasm 1 MYC
Melanosome 1 HSPA5
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
germ cell nucleus 1 TP53
replication fork 1 TP53
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 HSPA5, INS
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
male germ cell nucleus 1 CDK2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ANG
transport vesicle 1 INS
RNA polymerase II transcription repressor complex 1 MYC
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 EGFR
Cajal body 1 CDK2
endoplasmic reticulum-Golgi intermediate compartment 1 HSPA5
[Isoform 2]: Nucleus 1 CDH1
[Isoform 1]: Nucleus 1 TP53
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
apical junction complex 1 CDH1
Rough endoplasmic reticulum 1 MYC
condensed chromosome 1 CDK2
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CDH1
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
cyclin-dependent protein kinase holoenzyme complex 1 CDK2
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
endoplasmic reticulum chaperone complex 1 HSPA5
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin A2-CDK2 complex 1 CDK2
cyclin A1-CDK2 complex 1 CDK2
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • Xunliang Huang, Yue Xing, Hao Jiang, Ya Pu, Song Yang, Zhensheng Kang, Lin Cai. Nonphytotoxic and pH-responsive ZnO-ZIF‑8 loaded with honokiol as a 'nanoweapon' effectively controls the soil-borne bacterial pathogen Ralstonia solanacearum. Journal of hazardous materials. 2024 Jul; 472(?):134502. doi: 10.1016/j.jhazmat.2024.134502. [PMID: 38743980]
  • Xiuxia Li, Zhuo Yuan, Yuxia Wang, Wenjing Wang, Jianyou Shi. Recent advances of honokiol：pharmacological activities, manmade derivatives and structure-activity relationship. European journal of medicinal chemistry. 2024 Jun; 272(?):116471. doi: 10.1016/j.ejmech.2024.116471. [PMID: 38704945]
  • Weijuan Zou, Feng Gao, Zheying Meng, Xiaojun Cai, Wu Chen, Yuanyi Zheng, Tao Ying, Longchen Wang, Jianrong Wu. Lactic acid responsive sequential production of hydrogen peroxide and consumption of glutathione for enhanced ferroptosis tumor therapy. Journal of colloid and interface science. 2024 Jun; 663(?):787-800. doi: 10.1016/j.jcis.2024.03.001. [PMID: 38442520]
  • Zhuzhu Zhang, Tingting Chen, Xianhui Yin, Weizhen Wang, Wenzhi Li, Xuetang Chen, Jiling Ma, Youhua Long. Honokiol inhibits Botryosphaeria dothidea, the causal pathogen of kiwifruit soft rot, by targeting membrane lipid biosynthesis. Pest management science. 2024 Apr; 80(4):1779-1794. doi: 10.1002/ps.7910. [PMID: 38031205]
  • Katarzyna Szałabska-Rąpała, Maria Zych, Weronika Borymska, Piotr Londzin, Sławomir Dudek, Ilona Kaczmarczyk-Żebrowska. Beneficial effect of honokiol and magnolol on polyol pathway and oxidative stress parameters in the testes of diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Mar; 172(?):116265. doi: 10.1016/j.biopha.2024.116265. [PMID: 38364735]
  • Dan Liu, Linjiang Wang, Henan Li, Dong Li, Jianwen Zhou, Jing Wang, Qi Zhang, Defu Cai. Co-Delivery of Gemcitabine and Honokiol by Lipid Bilayer-Coated Mesoporous Silica Nanoparticles Enhances Pancreatic Cancer Therapy via Targeting Depletion of Tumor Stroma. Molecules (Basel, Switzerland). 2024 Jan; 29(3):. doi: 10.3390/molecules29030675. [PMID: 38338418]
  • Lin Niu, Shilong Wang, Yanyan Xu, Xingwang Zu, Xinyu You, Qiuyang Zhang, Pengwei Zhuang, Min Jiang, Jie Gao, Xiaotao Hou, Yanjun Zhang, Gang Bai, Jiagang Deng. Honokiol targeting ankyrin repeat domain of TRPV4 ameliorates endothelial permeability in mice inflammatory bowel disease induced by DSS. Journal of ethnopharmacology. 2024 Jan; 325(?):117825. doi: 10.1016/j.jep.2024.117825. [PMID: 38296175]
  • Yanli Zhang, Hui Liu, Zongxin Chen, Jialei Meng, Yunfeng Li, Luyao Qi, Suiliang Zhang, Xiaofeng Chen, Ming Lei. A drug-drug cocrystal and a co-amorphous form, prepared from honokiol and ligustrazine, inspired by Chinese patent medicine. Acta crystallographica Section B, Structural science, crystal engineering and materials. 2023 Dec; 79(Pt 6):519-524. doi: 10.1107/s2052520623008648. [PMID: 37966478]
  • Jie Li, Ya-Feng Chen, Lei Gao, Yi-Jie Li, Dian-Xu Feng. Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1. Chinese journal of integrative medicine. 2023 Nov; ?(?):. doi: 10.1007/s11655-023-3562-y. [PMID: 37943488]
  • Parteek Prasher, Rabab Fatima, Mousmee Sharma, Bekzat Tynybekov, Asma M Alshahrani, Dilek Arslan Ateşşahin, Javad Sharifi-Rad, Daniela Calina. Honokiol and its analogues as anticancer compounds: Current mechanistic insights and structure-activity relationship. Chemico-biological interactions. 2023 Oct; ?(?):110747. doi: 10.1016/j.cbi.2023.110747. [PMID: 37816447]
  • Ting Zhai, Junjun Wang, Yong Chen. Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice. Scientific reports. 2023 Sep; 13(1):15203. doi: 10.1038/s41598-023-42358-w. [PMID: 37709801]
  • Man Hu, Wen Jiang, Chen Ye, Ting Hu, Qingqing Yu, Moran Meng, Lijuan Sun, Jichao Liang, Yong Chen. Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1ɑ pathway in Schwann cells. Phytotherapy research : PTR. 2023 Aug; ?(?):. doi: 10.1002/ptr.7984. [PMID: 37580045]
  • Riccardo Fontana, Laura Beatrice Mattioli, Giulia Biotti, Roberta Budriesi, Roberto Gotti, Matteo Micucci, Ivan Corazza, Peggy Marconi, Maria Frosini, Stefano Manfredini, Raissa Buzzi, Silvia Vertuani. Magnolia officinalis L. bark extract and respiratory diseases: From traditional Chinese medicine to western medicine via network target. Phytotherapy research : PTR. 2023 Jul; 37(7):2915-2938. doi: 10.1002/ptr.7786. [PMID: 36879409]
  • Xian Wei, Yuzhi Wang, Yunlan Lao, Jiali Weng, Ruyu Deng, Shunmin Li, Jiandong Lu, Shudong Yang, Xinhui Liu. Effects of honokiol protects against chronic kidney disease via BNIP3/NIX and FUNDC1-mediated mitophagy and AMPK pathways. Molecular biology reports. 2023 Jun; ?(?):. doi: 10.1007/s11033-023-08592-1. [PMID: 37338733]
  • Zhi Zhang, Xin Shu, Qian Cao, Lushan Xu, Zibu Wang, Chenggang Li, Shengnan Xia, Pengfei Shao, Xinyu Bao, Liang Sun, Yuhao Xu, Yun Xu. Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models. Neuroscience bulletin. 2023 Jun; ?(?):. doi: 10.1007/s12264-023-01068-z. [PMID: 37291477]
  • Jae Hwa Seo, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Su-Yeon Park, Ah-Reum Cho, Jinsuk Koo, Bum Sang Shim, Bonglee Kim, Sung-Hoon Kim. Honokiol inhibits epithelial-mesenchymal transition and hepatic fibrosis via activation of Ecadherin/GSK3β/JNK and inhibition of AKT/ERK/p38/β-catenin/TMPRSS4 signaling axis. Phytotherapy research : PTR. 2023 May; ?(?):. doi: 10.1002/ptr.7871. [PMID: 37253375]
  • Jing Wang, Hui-Juan Mu, Yu-Li Sun, Bo Yuan, Ying Wang. Use of honokiol in lung cancer therapy: a mini review of its pharmacological mechanism. Journal of Asian natural products research. 2023 Apr; ?(?):1-9. doi: 10.1080/10286020.2023.2193695. [PMID: 37010929]
  • Anamika, Anima Roy, Surendra K Trigun. Hippocampus mitochondrial MnSOD activation by a SIRT3 activator, honokiol, correlates with its deacetylation and upregulation of FoxO3a and PGC1α in a rat model of ammonia neurotoxicity. Journal of cellular biochemistry. 2023 Mar; ?(?):. doi: 10.1002/jcb.30393. [PMID: 36922709]
  • Ishfaq Ahmad Rather, Nadeem Khan, Ajay Singh Kushwah, Gurunath Surampalli, Manish Kumar. Nephroprotective effects of honokiol in a high-fat diet-streptozotocin rat model of diabetic nephropathy. Life sciences. 2023 Mar; ?(?):121543. doi: 10.1016/j.lfs.2023.121543. [PMID: 36871934]
  • Shirui Ren, Yingming Yang, Mengying Xia, Yalan Deng, Yuling Zuo, Lei Lei, Tao Hu. A Chinese herb preparation, honokiol, inhibits Streptococcus mutans biofilm formation. Archives of oral biology. 2023 Mar; 147(?):105610. doi: 10.1016/j.archoralbio.2022.105610. [PMID: 36603516]
  • Qing Ma, Mengyang Xu, Xin Jing, Jiang Qiu, Shuo Huang, Honghao Yan, Lu Yin, Jiang Lou, Lisha Zhao, Yongsheng Fan, Ping Qiu. Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3/IL-33/ST2 axis. Cell death & disease. 2023 Mar; 14(3):174. doi: 10.1038/s41419-023-05680-9. [PMID: 36859530]
  • Chenchen Yang, Yinglian Zhao, Zhipan Luo, Ying Hu, Shuxian Wang, Shuang Hu, Yan Yao, Linxin Pan, Chuanpu Shen, Tao Xu. Honokiol Inhibits the Inflammatory Response and Lipid Metabolism Disorder by Inhibiting p38α in Alcoholic Liver Disease. Planta medica. 2023 Mar; 89(3):273-285. doi: 10.1055/a-1878-3991. [PMID: 35714651]
  • Xianxian Wang, Xiaobin Han, Shu Wang, Yaobin Wang, Peng Wang, Zhongli Zhao, Huimin Qin, Changliang Jing, Chen Liang. Extraction of honokiol from Artemisia argyi and in vitro and in vivo investigation of its antifungal activity. Natural product research. 2023 Feb; 37(4):651-656. doi: 10.1080/14786419.2022.2071887. [PMID: 35506313]
  • Xudong Cheng, Fei Wang, Yu Qiao, Ting Chen, Ling Fan, Xikun Shen, Dongwei Yu, Yuyu Huang, Minggang Wei. Honokiol inhibits interleukin-induced angiogenesis in the NSCLC microenvironment through the NF-κB signaling pathway. Chemico-biological interactions. 2023 Jan; 370(?):110295. doi: 10.1016/j.cbi.2022.110295. [PMID: 36470525]
  • Junzhao Yuan, Xiaoqian Huang, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian. Honokiol reduces cadmium-induced oxidative injury and endosomal/lysosomal vacuolation via protecting mitochondrial function in quail (Coturnix japonica) liver tissues. The Science of the total environment. 2023 Jan; 857(Pt 3):159626. doi: 10.1016/j.scitotenv.2022.159626. [PMID: 36280083]
  • Wei Zhang, Bangbang Li, Yangyong Lv, Shan Wei, Shuaibing Zhang, Yuansen Hu. Transcriptomic analysis shows the antifungal mechanism of honokiol against Aspergillus flavus. International journal of food microbiology. 2023 Jan; 384(?):109972. doi: 10.1016/j.ijfoodmicro.2022.109972. [PMID: 36279642]
  • Yu-Syuan Wei, Yu-Liang Chen, Wei-Yun Li, Ya-Yi Yang, Sung-Jan Lin, Ching-Ho Wu, Jiue-In Yang, Tse-En Wang, Jiashing Yu, Pei-Shiue Tsai. Antioxidant Nanoparticles Restore Cisplatin-Induced Male Fertility Defects by Promoting MDC1-53bp1-Associated Non-Homologous DNA Repair Mechanism and Sperm Intracellular Calcium Influx. International journal of nanomedicine. 2023; 18(?):4313-4327. doi: 10.2147/ijn.s408623. [PMID: 37576465]
  • Linzhou Yin, Pengyu Liu, Yue Jin, Zunxi Ning, Yiren Yang, Huiyuan Gao. Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications. European journal of medicinal chemistry. 2022 Dec; 244(?):114861. doi: 10.1016/j.ejmech.2022.114861. [PMID: 36332549]
  • Hui Li, Wanfang Li, Jie Li, Sizheng Li, Lian Kuang, Fei Pang, Haiyan Jiang, Hongtao Jin, Xiaolan Bian. Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway. Cells. 2022 11; 11(22):. doi: 10.3390/cells11223562. [PMID: 36428991]
  • Xin-Yuan Jiang, Zong-Yi Ren, Nian-Kun Zhang, Ke-Chen Yang, Gao-Xue Wang, Hai-Feng Jiang. Screening and evaluating honokiol from Magnolia officinalis against Nocardia seriolae infection in largemouth bass (Micropterus Salmoides). Journal of fish diseases. 2022 Nov; 45(11):1599-1607. doi: 10.1111/jfd.13683. [PMID: 35801398]
  • Jidan Zhang, Hongmei Li, Liwei Hou, Jianhui Sun, Weihao Wang, Hua Li, Weipeng Yang, Peijing Rong, Tiegui Nan, Liping Kang, Bin Yang. Pharmacokinetics and metabolites of glycosides and lignans of the stem bark of Magnolia officinalis in functional dyspepsia and normal rats using liquid chromatography-tandem mass spectrometry. Journal of separation science. 2022 Oct; 45(19):3663-3678. doi: 10.1002/jssc.202100982. [PMID: 35908283]
  • Nan Wang, Rui Kong, Wei Han, Wen Bao, Yihai Shi, LiPing Ye, Jie Lu. Honokiol alleviates ulcerative colitis by targeting PPAR-γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro. International immunopharmacology. 2022 Oct; 111(?):109058. doi: 10.1016/j.intimp.2022.109058. [PMID: 35901530]
  • Xinyue Lu, Xiaoyu Lu, Pei Yang, Zhenhai Zhang, Huixia Lv. Honokiol nanosuspensions loaded thermosensitive hydrogels as the local delivery system in combination with systemic paclitaxel for synergistic therapy of breast cancer. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2022 Aug; 175(?):106212. doi: 10.1016/j.ejps.2022.106212. [PMID: 35598854]
  • Ting Xu, Jie-Ru Meng, Wanqing Cheng, Jia-Zheng Liu, Junyan Chu, Qian Zhang, Nannan Ma, Li-Ping Bai, Yong Guo. Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors. Bioorganic & medicinal chemistry. 2022 08; 67(?):116838. doi: 10.1016/j.bmc.2022.116838. [PMID: 35617790]
  • Rui-Wen Mao, Shan-Ping He, Jun-Gang Lan, Wu-Zheng Zhu. Honokiol ameliorates cisplatin-induced acute kidney injury via inhibition of mitochondrial fission. British journal of pharmacology. 2022 07; 179(14):3886-3904. doi: 10.1111/bph.15837. [PMID: 35297042]
  • Fang Chen, Hao Zhang, Na Zhao, Encun Du, Feng Jin, Qiwen Fan, Wanzheng Guo, Shaowen Huang, Jintao Wei. Effects of magnolol and honokiol blend on performance, egg quality, hepatic lipid metabolism, and intestinal morphology of hens at late laying cycle. Animal : an international journal of animal bioscience. 2022 Jun; 16(6):100532. doi: 10.1016/j.animal.2022.100532. [PMID: 35576638]
  • Fawzy Elbarbry, Nicholas Moshirian. The Modulation of Arachidonic Acid Metabolism and Blood Pressure-Lowering Effect of Honokiol in Spontaneously Hypertensive Rats. Molecules (Basel, Switzerland). 2022 May; 27(11):. doi: 10.3390/molecules27113396. [PMID: 35684335]
  • Lin Niu, Jie Wang, Fukui Shen, Jie Gao, Min Jiang, Gang Bai. Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle. Journal of ethnopharmacology. 2022 May; 290(?):115105. doi: 10.1016/j.jep.2022.115105. [PMID: 35157953]
  • Akash Sabarwal, Johannes Wedel, Kaifeng Liu, David Zurakowski, Samik Chakraborty, Evelyn Flynn, David M Briscoe, Murugabaskar Balan, Soumitro Pal. A Combination therapy using an mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells and restricts renal tumor growth following organ transplantation. Carcinogenesis. 2022 05; 43(4):360-370. doi: 10.1093/carcin/bgab126. [PMID: 34965300]
  • Zili Ren, Min Lv, Yuling Zhang, Tianze Li, Hui Xu. High Value-Added Application of Natural Plant Products in Crop Protection: Honokiol Monoester/Diester Derivatives Containing the Novel Core Scaffold of Benzodihydrofuran and Their Agricultural Bioactivities and Control Effects. Journal of agricultural and food chemistry. 2022 May; 70(17):5319-5329. doi: 10.1021/acs.jafc.1c08292. [PMID: 35441514]
  • An-Liang Huang, Fan Yang, Ping Cheng, Dian-Ying Liao, Li Zhou, Xing-Li Ji, Dou-Dou Peng, Li Zhang, Ting-Ting Cheng, Li Ma, Xian-Gen Xia. Honokiol attenuate the arsenic trioxide-induced cardiotoxicity by reducing the myocardial apoptosis. Pharmacology research & perspectives. 2022 04; 10(2):e00914. doi: 10.1002/prp2.914. [PMID: 35171536]
  • Xiaolin Dai, Long Xie, Kai Liu, Youdan Liang, Yi Cao, Jing Lu, Xian Wang, Xumin Zhang, Xiaofang Li. The neuropharmacological effects of magnolol and honokiol：a review of signal pathways and molecular mechanisms. Current molecular pharmacology. 2022 Feb; ?(?):. doi: 10.2174/1874467215666220223141101. [PMID: 35196977]
  • Mari Endo, Tetsuro Oikawa, Miki Tonooka, Toshihiko Hanawa, Hiroshi Odaguchi, Masatoshi Hori. Hangekobokuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus through its anti-inflammatory action. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2022; 58(?):78-88. doi: 10.1540/jsmr.58.78. [PMID: 36216552]
  • Lu Wang, Junping Wang. Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier. Oxidative medicine and cellular longevity. 2022; 2022(?):1755608. doi: 10.1155/2022/1755608. [PMID: 36578522]
  • Linhua Lv, Qiuhuan Kong, Zhiying Li, Ying Zhang, Bijiao Chen, Lihua Lv, Yubi Zhang. Honokiol Provides Cardioprotection from Myocardial Ischemia/Reperfusion Injury (MI/RI) by Inhibiting Mitochondrial Apoptosis via the PI3K/AKT Signaling Pathway. Cardiovascular therapeutics. 2022; 2022(?):1001692. doi: 10.1155/2022/1001692. [PMID: 35414825]
  • Xiangxiang Zhang, Huaen Chen, Yang Zhang, Qijing Huang, Jianjia Feng, Haoyu Xing, Xiaguo Fu, Xiufang Yan, Yingying Zhang, Qin Xu, Jianming Liang. HA-DOPE-Modified Honokiol-Loaded Liposomes Targeted Therapy for Osteosarcoma. International journal of nanomedicine. 2022; 17(?):5137-5151. doi: 10.2147/ijn.s371934. [PMID: 36345507]
  • Sayeh Mottaghi, Hassan Abbaszadeh. Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review. Nutrition and cancer. 2022; 74(3):761-778. doi: 10.1080/01635581.2021.1931364. [PMID: 34047218]
  • Linhua Li, Chong Chen, Chunle Zhang, Rifang Luo, Xiaorong Lan, Fan Guo, Liang Ma, Ping Fu, Yunbing Wang. A honokiol-mediated robust coating for blood-contacting devices with anti-inflammatory, antibacterial and antithrombotic properties. Journal of materials chemistry. B. 2021 12; 9(47):9770-9783. doi: 10.1039/d1tb01617b. [PMID: 34806726]
  • Chung-Ping Yu, Pei-Ying Li, Szu-Yu Chen, Shiuan-Pey Lin, Yu-Chi Hou. Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration. Molecules (Basel, Switzerland). 2021 Dec; 26(23):. doi: 10.3390/molecules26237390. [PMID: 34885972]
  • Xiaohu Liu, Yuanzuo Li, Qilei Yang, Hongda Cai, Lingling Wang, Xiuhua Zhao. Improving the antioxidant activity of natural antioxidant honokiol by introducing the amino group. Journal of molecular modeling. 2021 Nov; 27(12):350. doi: 10.1007/s00894-021-04977-w. [PMID: 34757484]
  • Daria D Vaulina, Kira I Stosman, Konstantin V Sivak, Andrey G Aleksandrov, Nikolai B Viktorov, Nikolay N Kuzmich, Mariia M Kiseleva, Olga F Kuznetsova, Natalia A Gomzina. Preliminary Assessment of the Anti-inflammatory Activity of New Structural Honokiol Analogs with a 4'-O-(2-Fluoroethyl) Moiety and the Potential of Their 18F-Labeled Derivatives for Neuroinflammation Imaging. Molecules (Basel, Switzerland). 2021 Nov; 26(21):. doi: 10.3390/molecules26216630. [PMID: 34771039]
  • Hongyan Zhang, Ji Li, Rong Yuan, Yufen Li, Yue Zhang, Xiaoyun Hu, Jiqiang Qu, Yu Chen, Zheran Wang, Mingyu Xia, Dongkai Wang. Augment the efficacy of eradicating metastatic lesions and tumor proliferation in breast cancer by honokiol-loaded pH-sensitive targeted lipid nanoparticles. Colloids and surfaces. B, Biointerfaces. 2021 Nov; 207(?):112008. doi: 10.1016/j.colsurfb.2021.112008. [PMID: 34333303]
  • Ting Xu, Wenyue Tian, Qian Zhang, Jiazheng Liu, Zhiyan Liu, Jing Jin, Yong Guo, Li-Ping Bai. Novel 1,3,4-thiadiazole/oxadiazole-linked honokiol derivatives suppress cancer via inducing PI3K/Akt/mTOR-dependent autophagy. Bioorganic chemistry. 2021 10; 115(?):105257. doi: 10.1016/j.bioorg.2021.105257. [PMID: 34426156]
  • Yu Zhang, Ping Wen, Jing Luo, Hao Ding, Hongdi Cao, Weichun He, Ke Zen, Yang Zhou, Junwei Yang, Lei Jiang. Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis. Cell death & disease. 2021 09; 12(9):847. doi: 10.1038/s41419-021-04134-4. [PMID: 34518519]
  • Abdur Rauf, Ahmed Olatunde, Muhammad Imran, Fahad A Alhumaydhi, Abdullah S M Aljohani, Shahid Ali Khan, Md Sahab Uddin, Saikat Mitra, Talha Bin Emran, Mars Khayrullin, Maksim Rebezov, Mohammad Amjad Kamal, Mohammad Ali Shariati. Honokiol: A review of its pharmacological potential and therapeutic insights. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Sep; 90(?):153647. doi: 10.1016/j.phymed.2021.153647. [PMID: 34362632]
  • Vittoria Borgonetti, Paolo Governa, Fabrizio Manetti, Elisabetta Miraldi, Marco Biagi, Nicoletta Galeotti. A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor. The Journal of pharmacy and pharmacology. 2021 Aug; 73(9):1161-1168. doi: 10.1093/jpp/rgab067. [PMID: 33950239]
  • Guo-Guang Lou, Yi-Ting Luo, Li-Ping Xie, Hang-Ping Yao, Qing Hu. Mechanism of apoptotic induction on T24 cells by honokiol and its synergistic anticancer effect in combination with hydroxycamptothecin. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2021 08; 41(4):515-522. doi: 10.19852/j.cnki.jtcm.2021.03.003. [PMID: 34392643]
  • Zhengqi Dong, Hanhong Qiu, Meihua Han, Rui Wang, Yifei Guo, Xiangtao Wang. Honokiol-Based Nanomedicine Decorated with Ethylene Glycols Derivatives Promotes Antitumor Efficacy. Journal of biomedical nanotechnology. 2021 Aug; 17(8):1564-1573. doi: 10.1166/jbn.2021.3126. [PMID: 34544534]
  • Cheng Chen, Qing-Wen Zhang, Yang Ye, Li-Gen Lin. Honokiol: A naturally occurring lignan with pleiotropic bioactivities. Chinese journal of natural medicines. 2021 Jul; 19(7):481-490. doi: 10.1016/s1875-5364(21)60047-x. [PMID: 34247771]
  • Jing An, Chaoxing He, Caihui Guo, Zhanjun Dong. Application of hollow fiber centrifugal ultrafiltrate purification as the pretreatment technology for traditional Chinese medicine: its application for analysis of honokiol and magnolol in TCM preparations containing Cortex Magnoliae Officinalis. Annals of palliative medicine. 2021 Jun; 10(6):6359-6366. doi: 10.21037/apm-21-242. [PMID: 33752432]
  • Young-Seok Lee, Suyun Jeong, Ki-Yoon Kim, Ji-Su Yoon, Sungsoo Kim, Kyung-Sik Yoon, Joohun Ha, Insug Kang, Wonchae Choe. Honokiol inhibits hepatoma carcinoma cell migration through downregulated Cyclophilin B expression. Biochemical and biophysical research communications. 2021 05; 552(?):44-51. doi: 10.1016/j.bbrc.2021.03.011. [PMID: 33743348]
  • Yuhong Cao, Yan Cao, Yiwei Shi, Ying Cai, Langdong Chen, Dongyao Wang, Yue Liu, Xiaofei Chen, Zhenyu Zhu, Zhanying Hong, Yifeng Chai. Surface plasmon resonance biosensor combined with lentiviral particle stabilization strategy for rapid and specific screening of P-Glycoprotein ligands. Analytical and bioanalytical chemistry. 2021 Mar; 413(7):2021-2031. doi: 10.1007/s00216-021-03170-5. [PMID: 33528601]
  • Kuo-Chou Chiu, Yin-Hwa Shih, Tong-Hong Wang, Wan-Chen Lan, Po-Jung Li, Hong-Syu Jhuang, Shih-Min Hsia, Yen-Wen Shen, Michael Yuan-Chien Chen, Tzong-Ming Shieh. In vitro antimicrobial and antipro-inflammation potential of honokiol and magnolol against oral pathogens and macrophages. Journal of the Formosan Medical Association = Taiwan yi zhi. 2021 Feb; 120(2):827-837. doi: 10.1016/j.jfma.2020.09.002. [PMID: 32978046]
  • Hong-Liang Lin, Wen-Ting Cheng, Ling-Chun Chen, Hsiu-O Ho, Shyr-Yi Lin, Chien-Ming Hsieh. Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability. International journal of nanomedicine. 2021; 16(?):651-665. doi: 10.2147/ijn.s290444. [PMID: 33536753]
  • Hyojin Kim, Chae Yeon Lim, Mi Sook Chung. Magnolia officinalis and Its Honokiol and Magnolol Constituents Inhibit Human Norovirus Surrogates. Foodborne pathogens and disease. 2021 01; 18(1):24-30. doi: 10.1089/fpd.2020.2805. [PMID: 32716659]
  • Lingmei Sun, Kai Liao. The Effect of Honokiol on Ergosterol Biosynthesis and Vacuole Function in Candida albicans. Journal of microbiology and biotechnology. 2020 12; 30(12):1835-1842. doi: 10.4014/jmb.2008.08019. [PMID: 33263334]
  • Yin-Fang Yan, Cheng-Jie Yang, Xiao-Fei Shang, Zhong-Min Zhao, Ying-Qian Liu, Rui Zhou, Hua Liu, Tian-Lin Wu, Wen-Bin Zhao, Yu-Ling Wang, Guan-Fang Hu, Fang Qin, Ying-Hui He, Hai-Xin Li, Sha-Sha Du. Bioassay-guided isolation of two antifungal compounds from Magnolia officinalis, and the mechanism of action of honokiol. Pesticide biochemistry and physiology. 2020 Nov; 170(?):104705. doi: 10.1016/j.pestbp.2020.104705. [PMID: 32980068]
  • Wei Huang, Hang Liu, Yu Li, Gang Mai. The Effects of Rhein and Honokiol on Metabolic Profiles in a Mouse Model of Acute Pancreatitis. Medical science monitor : international medical journal of experimental and clinical research. 2020 Oct; 26(?):e925727. doi: 10.12659/msm.925727. [PMID: 33095758]
  • Shin-Ruen Yang, Wan-Han Hsu, Chung-Yao Wu, Hung-Sheng Shang, Feng-Cheng Liu, Ann Chen, Kuo-Feng Hua, Shuk-Man Ka. Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-κB/NLRP3 inflammasome and sirtuin 1/autophagy axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 10; 34(10):13284-13299. doi: 10.1096/fj.202001326r. [PMID: 32813287]
  • Bo Zhang, Yu Li, Miao Liu, Xiao-Hua Duan, Kai-Li Hu, Li-Na Li, Xue Yu, Hong-Sheng Chang. Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression. Journal of integrative neuroscience. 2020 Sep; 19(3):459-467. doi: 10.31083/j.jin.2020.03.172. [PMID: 33070525]
  • Zhexi Chi, Truc Phan Hoang Le, Sang Ki Lee, Erling Guo, Dongsoo Kim, Sanha Lee, Seung-Yong Seo, Sook Young Lee, Jae Hyung Kim, Sang Yoon Lee. Honokiol ameliorates angiotensin II-induced hypertension and endothelial dysfunction by inhibiting HDAC6-mediated cystathionine γ-lyase degradation. Journal of cellular and molecular medicine. 2020 09; 24(18):10663-10676. doi: 10.1111/jcmm.15686. [PMID: 32755037]
  • Jingwei Zhou, Yaoyao Hu, Peichun Chen, Hongwu Zhang. Preparation of restricted access monolithic tip via unidirectional freezing and atom transfer radical polymerization for directly extracting magnolol and honokiol from rat plasma followed by liquid chromatography analysis. Journal of chromatography. A. 2020 Aug; 1625(?):461238. doi: 10.1016/j.chroma.2020.461238. [PMID: 32709314]
  • Eliza Łata, Agnieszka Fulczyk, Péter G Ott, Teresa Kowalska, Mieczysław Sajewicz, Ágnes M Móricz. Thin-layer chromatographic quantification of magnolol and honokiol in dietary supplements and selected biological properties of these preparations. Journal of chromatography. A. 2020 Aug; 1625(?):461230. doi: 10.1016/j.chroma.2020.461230. [PMID: 32709311]
  • Danting Li, Bo Lv, Di Wang, Doudou Xu, Siyuan Qin, Ying Zhang, Jie Chen, Wei Zhang, Zunjian Zhang, Fengguo Xu. Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Jul; 72(?):153236. doi: 10.1016/j.phymed.2020.153236. [PMID: 32464544]
  • Ming-Huan Chan, Hwei-Hsien Chen, Yi-Ching Lo, Sheng-Nan Wu. Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from Magnolia Officinalis, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K+ Current. International journal of molecular sciences. 2020 Jun; 21(12):. doi: 10.3390/ijms21124260. [PMID: 32549398]
  • Danying Ma, Xiaomin Cui, Zhanquan Zhang, Boqiang Li, Yong Xu, Shiping Tian, Tong Chen. Honokiol suppresses mycelial growth and reduces virulence of Botrytis cinerea by inducing autophagic activities and apoptosis. Food microbiology. 2020 Jun; 88(?):103411. doi: 10.1016/j.fm.2019.103411. [PMID: 31997759]
  • Monica Locatelli, Carlamaria Zoja, Cristina Zanchi, Daniela Corna, Sebastian Villa, Silvia Bolognini, Rubina Novelli, Luca Perico, Giuseppe Remuzzi, Ariela Benigni, Paola Cassis. Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes. Scientific reports. 2020 05; 10(1):8418. doi: 10.1038/s41598-020-65423-0. [PMID: 32439965]
  • Ming Li, Can-Ming Li, Zeng-Chun Ye, Jiayan Huang, Yin Li, Weiyan Lai, Hui Peng, Tan-Qi Lou. Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice. Journal of cellular and molecular medicine. 2020 05; 24(9):5109-5121. doi: 10.1111/jcmm.15148. [PMID: 32281286]
  • Xiao-Yan Zhi, Ling-Yun Jiang, Ting Li, Li-Li Song, Yi Wang, Hui Cao, Chun Yang. Semisynthesis and insecticidal bioactivities of benzoxazole and benzoxazolone derivatives of honokiol, a naturally occurring neolignan derived from Magnolia officinalis. Bioorganic & medicinal chemistry letters. 2020 05; 30(9):127086. doi: 10.1016/j.bmcl.2020.127086. [PMID: 32165043]
  • Yuanzhi He, Xuefeng Hou, Jingwen Guo, Zehui He, Teng Guo, Ying Liu, Yongtai Zhang, Jiwen Zhang, Nianping Feng. Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol. Carbohydrate polymers. 2020 May; 235(?):115935. doi: 10.1016/j.carbpol.2020.115935. [PMID: 32122478]
  • Jiahui Sun, Jing Li, Qi Liu, Min Jiang, Mengjia Yang, Siwen Zhan, Tong Qiu, Kaiyong He, Xueqiong Zhang. Tuning mPEG-PLA/vitamin E-TPGS-based mixed micelles for combined celecoxib/honokiol therapy for breast cancer. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Apr; 146(?):105277. doi: 10.1016/j.ejps.2020.105277. [PMID: 32105783]
  • Qi Zhang, Gang Cheng, Jing Pan, Jacek Zielonka, Donghai Xiong, Charles R Myers, Liang Feng, Song Seok Shin, Young Heui Kim, Dinh Bui, Ming Hu, Brian Bennett, Kathleen Schmainda, Yian Wang, Balaraman Kalyanaraman, Ming You. Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I. Cell communication and signaling : CCS. 2020 04; 18(1):58. doi: 10.1186/s12964-020-0524-2. [PMID: 32264893]
  • Jing Li, Daniëlle Copmans, Michèle Partoens, Borbála Hunyadi, Walter Luyten, Peter de Witte. Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model. ACS chemical neuroscience. 2020 03; 11(5):730-742. doi: 10.1021/acschemneuro.9b00610. [PMID: 32083464]
  • Xinyue Lu, Xiaoyu Lu, Zhenhai Zhang, Huixia Lv. Preparation and Characterization of Honokiol Nanosuspensions and Preliminary Evaluation of Anti-Inflammatory Effect. AAPS PharmSciTech. 2020 Jan; 21(2):62. doi: 10.1208/s12249-019-1602-x. [PMID: 31925586]
  • Yi Quan, Woong Park, Jixiu Jin, Won Kim, Sung Kwang Park, Kyung Pyo Kang. Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-κBTGF-β1/Smad Signaling Pathway. International journal of molecular sciences. 2020 Jan; 21(2):. doi: 10.3390/ijms21020402. [PMID: 31936371]
  • Isaac Eliaz, Elaine Weil. Intravenous Honokiol in Drug-Resistant Cancer: Two Case Reports. Integrative cancer therapies. 2020 Jan; 19(?):1534735420922615. doi: 10.1177/1534735420922615. [PMID: 32482152]
  • Yasaman Hamedani, Samik Chakraborty, Akash Sabarwal, Soumitro Pal, Sankha Bhowmick, Murugabaskar Balan. Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells. PloS one. 2020; 15(12):e0243837. doi: 10.1371/journal.pone.0243837. [PMID: 33332399]
  • Marie-Blanche Onselaer, Magdolna Nagy, Chiara Pallini, Jeremy A Pike, Gina Perrella, Lourdes Garcia Quintanilla, Johannes A Eble, Natalie S Poulter, Johan W M Heemskerk, Steve P Watson. Comparison of the GPVI inhibitors losartan and honokiol. Platelets. 2020; 31(2):187-197. doi: 10.1080/09537104.2019.1585526. [PMID: 30849265]
  • Ting Zhai, Wei Xu, Yayun Liu, Kun Qian, Yanling Xiong, Yong Chen. Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway. Oxidative medicine and cellular longevity. 2020; 2020(?):2313641. doi: 10.1155/2020/2313641. [PMID: 33354276]
  • Yuan Yuan, Xiaocui Zhou, Yuanyuan Wang, Yan Wang, Xiangyan Teng, Shuaiyu Wang. Cardiovascular Modulating Effects of Magnolol and Honokiol, Two Polyphenolic Compounds from Traditional Chinese Medicine-Magnolia Officinalis. Current drug targets. 2020; 21(6):559-572. doi: 10.2174/1389450120666191024175727. [PMID: 31749425]
  • Xin Jin, Qing Yang, Ning Cai, Zhenhai Zhang. A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment. Nanomedicine (London, England). 2020 01; 15(1):41-54. doi: 10.2217/nnm-2018-0479. [PMID: 31868113]
  • Chon Phin Ong, Wai Leong Lee, Yin Quan Tang, Wei Hsum Yap. Honokiol: A Review of Its Anticancer Potential and Mechanisms. Cancers. 2019 Dec; 12(1):. doi: 10.3390/cancers12010048. [PMID: 31877856]
  • Da Qing Yu, Xiao Jing Han, Ting Yu Shan, Rui Xu, Jin Hu, Wang Xing Cheng, Liang Ping Zha, Hua Sheng Peng. Microscopic Characteristic and Chemical Composition Analysis of Three Medicinal Plants and Surface Frosts. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244548. [PMID: 31842368]
  • Seon Min Woo, Seung Un Seo, Peter Kubatka, Kyoung-Jin Min, Taeg Kyu Kwon. Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation. Biomolecules. 2019 12; 9(12):. doi: 10.3390/biom9120838. [PMID: 31817770]
  • Jing Li, Ming-Rui Li, Bao Sun, Cheng-Ming Liu, Jing Ren, Wen-Qian Zhi, Pei-Yu Zhang, Hai-Ling Qiao, Na Gao. Inhibition of Rat CYP1A2 and CYP2C11 by Honokiol, a Component of Traditional Chinese Medicine. European journal of drug metabolism and pharmacokinetics. 2019 Dec; 44(6):787-796. doi: 10.1007/s13318-019-00565-9. [PMID: 31175627]
  • Senyi Deng, ChuanFen Zhang, Lina Yang, Liang Ma. Formylated honokiol analogs showed antitumor activity against lung carcinoma. Anti-cancer drugs. 2019 09; 30(8):795-802. doi: 10.1097/cad.0000000000000771. [PMID: 30807551]
  • Wen-Die Wang, Yue Shang, Yi Li, Shu-Zhen Chen. Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation. Acta pharmacologica Sinica. 2019 Sep; 40(9):1219-1227. doi: 10.1038/s41401-019-0240-x. [PMID: 31235819]
  • Ding Lin, Zhongzhong Yan, Aiyu Chen, Jiao Ye, Aixi Hu, Juan Liu, Junmei Peng, Xiaoyun Wu. Anti-proliferative activity and structure-activity relationship of honokiol derivatives. Bioorganic & medicinal chemistry. 2019 08; 27(16):3729-3734. doi: 10.1016/j.bmc.2019.06.042. [PMID: 31278004]
  • Feng-Ling Yu, Jun-Wen Wu, He Zhu. Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver. Life sciences. 2019 Aug; 230(?):97-103. doi: 10.1016/j.lfs.2019.05.062. [PMID: 31129139]