Spermidine (BioDeep_00000002888)

 

Secondary id: BioDeep_00000405429, BioDeep_00000866929

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Toxin


代谢物信息卡片


N-(gamma-Aminopropyl)tetramethylenediamine

化学式: C7H19N3 (145.1578894)
中文名称: 亚精胺, 亚精胺
谱图信息: 最多检出来源 Homo sapiens(blood) 0.03%

分子结构信息

SMILES: C(CCNCCCN)CN
InChI: InChI=1/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

描述信息

Spermidine, also known as SPD, belongs to the class of organic compounds known as dialkylamines. These are organic compounds containing a dialkylamine group, characterized by two alkyl groups bonded to the amino nitrogen. Abnormal bleeding, such as bleeding spontaneously or profusely from a very minor injury can also occur. Spermidine exists in all living species, ranging from bacteria to humans. Within humans, spermidine participates in a number of enzymatic reactions. In particular, 5-methylthioadenosine and spermidine can be biosynthesized from S-adenosylmethioninamine and putrescine by the enzyme spermidine synthase. In addition, S-adenosylmethioninamine and spermidine can be converted into 5-methylthioadenosine and spermine through the action of the enzyme spermine synthase. In humans, spermidine is involved in spermidine and spermine biosynthesis. Outside of the human body, spermidine is found, on average, in the highest concentration within cow milk and oats. Spermidine has also been detected, but not quantified in several different foods, such as common chokecherries, watercress, agars, strawberry guava, and bog bilberries. This could make spermidine a potential biomarker for the consumption of these foods. Spermidine is consideres as an uremic toxine. Increased levels of uremic toxins can stimulate the production of reactive oxygen species. Chronic exposure to uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease. As a uremic toxin, this compound can cause uremic syndrome. Uremic toxins such as spermidine are actively transported into the kidneys via organic ion transporters (especially OAT3).
Constituent of meat products. Isol from the edible shaggy ink cap mushroom (Coprinus comatus) and from commercial/household prepared sauerkraut
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
IPB_RECORD: 269; CONFIDENCE confident structure
CONFIDENCE standard compound; INTERNAL_ID 220
KEIO_ID S003
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents[1].
Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents[1].

同义名列表

17 个代谢物同义名

N-(gamma-Aminopropyl)tetramethylenediamine; N-(3-Aminopropyl)-1,4-butane-diamine; N-(3-Aminopropyl)-1,4-diamino-butane; N-(3-Aminopropyl)-4-aminobutylamine; N-(3-Aminopropyl)-1,4-butanediamine; N-(4-Aminobutyl)-1,3-diaminopropane; N-(3-Aminopropyl)-1,4-diaminobutane; (4-aminobutyl)(3-aminopropyl)amine; 4-Azaoctamethylenediamine; 1,8-Diamino-4-azaoctane; Aminopropylbutandiamine; 4-Azaoctane-1,8-diamine; 1,5,10-Triazadecane; Spermidine; Spermidin; SPD; Spermidine



数据库引用编号

44 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

397 个相关的代谢反应过程信息。

Reactome(42)

BioCyc(10)

WikiPathways(0)

Plant Reactome(307)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(37)

PharmGKB(0)

131 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jianhua Zhao, Yuhui Xu, Haoxia Li, Wei An, Yue Yin, Bin Wang, Liping Wang, Bi Wang, Linyuan Duan, Xiaoyue Ren, Xiaojie Liang, Yajun Wang, Ru Wan, Ting Huang, Bo Zhang, Yanlong Li, Jie Luo, Youlong Cao. Metabolite-based genome-wide association studies enable the dissection of the genetic bases of flavonoids, betaine and spermidine in wolfberry (Lycium). Plant biotechnology journal. 2024 Jun; 22(6):1435-1452. doi: 10.1111/pbi.14278. [PMID: 38194521]
  • Bin Li, Jue Liang, Hamid R Baniasadi, Shin Kurihara, Margaret A Phillips, Anthony J Michael. Functional identification of bacterial spermine, thermospermine, norspermine, norspermidine, spermidine, and N1-aminopropylagmatine synthases. The Journal of biological chemistry. 2024 May; 300(5):107281. doi: 10.1016/j.jbc.2024.107281. [PMID: 38588807]
  • Ludan Cao, Guo Wang, Xiuxu Ye, Fang Li, Shujun Wang, Huanling Li, Peng Wang, Jiabao Wang. Physiological, Metabolic, and Transcriptomic Analyses Reveal Mechanisms of Proliferation and Somatic Embryogenesis of Litchi (Litchi chinensis Sonn.) Embryogenic Callus Promoted by D-Arginine Treatment. International journal of molecular sciences. 2024 Apr; 25(7):. doi: 10.3390/ijms25073965. [PMID: 38612774]
  • Jiangtao Qiao, Wenwen Cai, Kai Wang, Eric Haubruge, Jie Dong, Hesham R El-Seedi, Xiang Xu, Hongcheng Zhang. New Insights into Identification, Distribution, and Health Benefits of Polyamines and Their Derivatives. Journal of agricultural and food chemistry. 2024 Mar; 72(10):5089-5106. doi: 10.1021/acs.jafc.3c08556. [PMID: 38416110]
  • Hong Deng, Qiandong Hou, Zhuang Wen, Runrun Yu, Xuejiao Cao, Chunqiong Shang, Xiaowei Cai, Guang Qiao. Chinese cherry CpMYB44-CpSPDS2 module regulates spermidine content and florescence in tobacco. Physiologia plantarum. 2024 Mar; 176(2):e14300. doi: 10.1111/ppl.14300. [PMID: 38629194]
  • Peng Gao, Jianyou Wang, Huan Tang, Huanhuan Pang, Jiemei Liu, Chen Wang, Fei Xia, Honglin Chen, Liting Xu, Junzhe Zhang, Lixia Yuan, Guang Han, Jigang Wang, Gang Liu. Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis. Cell communication and signaling : CCS. 2024 02; 22(1):139. doi: 10.1186/s12964-023-01409-5. [PMID: 38378659]
  • Xueni Zhang, Xiaoyan Wen, Di Zhou, Yuhang Liang, Zhengqun Zhou, Gang Chen, Wei Li, Hao Gao, Ning Li. Lycibarbarspermidine L from the fruit of Lycium barbarum L. recovers intestinal barrier damage via regulating miR-195-3p. Journal of ethnopharmacology. 2024 Feb; 320(?):117419. doi: 10.1016/j.jep.2023.117419. [PMID: 37977423]
  • Bizhen Cheng, Muhammad Jawad Hassan, Dandan Peng, Ting Huang, Yan Peng, Zhou Li. Spermidine or spermine pretreatment regulates organic metabolites and ions homeostasis in favor of white clover seed germination against salt toxicity. Plant physiology and biochemistry : PPB. 2024 Jan; 207(?):108379. doi: 10.1016/j.plaphy.2024.108379. [PMID: 38266560]
  • Shoucheng Huang, Ping Huang, Sajid Masood, Muhammad Mazhar Iqbal, Tayyaba Naz, Subhan Danish, Mohammad Javed Ansari, Saleh H Salmen. Enhancing maize growth through the synergistic impact of potassium enrich biochar and spermidine. BMC plant biology. 2024 Jan; 24(1):36. doi: 10.1186/s12870-024-04722-4. [PMID: 38191323]
  • Yinhua Ni, Liujie Zheng, Liqian Zhang, Jiamin Li, Yuxiang Pan, Haimei Du, Zhaorong Wang, Zhengwei Fu. Spermidine activates adipose tissue thermogenesis through autophagy and fibroblast growth factor 21. The Journal of nutritional biochemistry. 2024 Jan; 125(?):109569. doi: 10.1016/j.jnutbio.2024.109569. [PMID: 38185346]
  • Kai Yin, Guobing Cui, Xinping Bi, Meiling Liang, Zhijian Hu, Yi Zhen Deng. Intracellular polyamines regulate redox homeostasis with cAMP-PKA signalling during sexual mating/filamentation and pathogenicity of Sporisorium scitamineum. Molecular plant pathology. 2024 Jan; 25(1):e13393. doi: 10.1111/mpp.13393. [PMID: 37814404]
  • P R Manhone, J C Lopes, R S Alexandre, P A M Lima, S O Lopes, L H G Mengarda, T Mello. Plant growth regulators and mobilization of reserves in imbibition phases of yellow passion fruit. Brazilian journal of biology = Revista brasleira de biologia. 2024; 84(?):e273999. doi: 10.1590/1519-6984.273999. [PMID: 38451628]
  • Wenjuan Wang, Shangli Shi, Wenjuan Kang, Long He. Enriched endogenous free Spd and Spm in alfalfa (Medicago sativa L.) under drought stress enhance drought tolerance by inhibiting H2O2 production to increase antioxidant enzyme activity. Journal of plant physiology. 2023 Dec; 291(?):154139. doi: 10.1016/j.jplph.2023.154139. [PMID: 37988872]
  • Edward Calabrese, A Wallace Hayes, Peter Pressman, Rachna Kapoor, Gaurav Dhawan, Vittorio Calabrese, Evgenios Agathokleous. Polyamines and hormesis: Making sense of a dose response dichotomy. Chemico-biological interactions. 2023 Dec; 386(?):110748. doi: 10.1016/j.cbi.2023.110748. [PMID: 37816449]
  • Naouar Ben Ali, Rajae Benkaddour, Safaa Rahmouni, Ouafaa Hamdoun, Ibtissam Boussaoudi, Mustapha Hassoun, Latifa Azaroual, Alain Badoc, Patrick Martin, Ahmed Lamarti. Influence of exogenous polyamines on the secondary somatic embryogenesis of cork oak (Quercus suber L.). Bioengineered. 2023 12; 14(1):2288354. doi: 10.1080/21655979.2023.2288354. [PMID: 38031347]
  • Meng-Hua Ma, Lei-Lei Gao, Chuang-Bo Chen, Fang-Li Gu, Si-Qi Wu, Fang Li, Bang-Xing Han. Dendrobium huoshanense Polysaccharide Improves High-Fat Diet Induced Liver Injury by Regulating the Gut-Liver Axis. Chemistry & biodiversity. 2023 Nov; 20(11):e202300980. doi: 10.1002/cbdv.202300980. [PMID: 37831331]
  • Huachao Xi, Xiaoqun Nie, Fang Gao, Xinxin Liang, Hu Li, Haiyan Zhou, Yujie Cai, Chen Yang. A bacterial spermidine biosynthetic pathway via carboxyaminopropylagmatine. Science advances. 2023 10; 9(43):eadj9075. doi: 10.1126/sciadv.adj9075. [PMID: 37878710]
  • Juan Li, Qi Li, Nian Guo, Qinglin Xian, Bing Lan, Nangia Vinay, Fei Mo, Yang Liu. Polyamines mediate the inhibitory effect of drought stress on nitrogen reallocation and utilization to regulate the grain number in wheat. Journal of experimental botany. 2023 Oct; ?(?):. doi: 10.1093/jxb/erad393. [PMID: 37813095]
  • Zhi-Qiang Yu, Jia-Yuan Hu, Shang-Ke Li, Wei-Lin Shi, Guang-Yu Shi. [Exogenous Spermidine Regulates Ryegrass Root System Response to Cd Stress and Its Transcriptome Analysis]. Huan jing ke xue= Huanjing kexue. 2023 Oct; 44(10):5746-5756. doi: 10.13227/j.hjkx.202210060. [PMID: 37827790]
  • Zhennan Zhan, Ning Wang, Zumin Chen, Yanxia Zhang, Kangqi Geng, Dongmei Li, Zhenping Wang. Effects of water stress on endogenous hormones and free polyamines in different tissues of grapevines (Vitis vinifera L. cv. 'Merlot'). Functional plant biology : FPB. 2023 Oct; ?(?):. doi: 10.1071/fp22225. [PMID: 37788830]
  • Andleeb Zehra, Harshal V Dhondge, Vitthal T Barvkar, Sanjay K Singh, Altafhusain B Nadaf. Evidence of polyamines mediated 2-acetyl-1-pyrroline biosynthesis in aromatic rice rhizospheric fungal species Aspergillus niger. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. 2023 Sep; ?(?):. doi: 10.1007/s42770-023-01124-w. [PMID: 37702923]
  • Wanhui Wei, Yuanyuan Lu, Qian Hu, Jinwen Yin, Youwei Wang, Heng Zhang, Qiu Zhao, Lan Liu. Synergistic antitumor efficacy of gemcitabine and cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via Sp1-SAT1-polyamine metabolism pathway. Cellular oncology (Dordrecht). 2023 Sep; ?(?):. doi: 10.1007/s13402-023-00870-1. [PMID: 37684512]
  • Yonghong He, Nannan Su, Qingzhao Zhao, Jiaer Meng, Zhaojin Chen, Hui Han. Polyamine-producing bacteria inhibit the absorption of Cd by spinach and alter the bacterial community composition of rhizosphere soil. Ecotoxicology and environmental safety. 2023 Sep; 264(?):115442. doi: 10.1016/j.ecoenv.2023.115442. [PMID: 37672938]
  • Kritika Kaushal, Mohd Ali, Puja Ohri. Uncovering the synergistic interplay of melatonin and spermidine in the alleviation of nematode stress in Solanum lycopersicum. Pesticide biochemistry and physiology. 2023 Sep; 195(?):105574. doi: 10.1016/j.pestbp.2023.105574. [PMID: 37666625]
  • Muhammad Asif Shehzad, Israr Hussain, Gulzar Akhtar, Khawaja Shafique Ahmad, Fahim Nawaz, Hafiz Nazar Faried, Ansar Mehmood. Insights into physiological and metabolic modulations instigated by exogenous sodium nitroprusside and spermidine reveals drought tolerance in Helianthus annuus L. Plant physiology and biochemistry : PPB. 2023 Aug; 202(?):107935. doi: 10.1016/j.plaphy.2023.107935. [PMID: 37579683]
  • Elžbieta Jankovska-Bortkevič, Sigita Jurkonienė, Virgilija Gavelienė, Vaidevutis Šveikauskas, Rima Mockevičiūtė, Irina Vaseva, Dessislava Todorova, Marija Žižytė-Eidetienė, Donatas Šneideris, Petras Prakas. Dynamics of Polyamines, Proline, and Ethylene Metabolism under Increasing Cold in Winter Oilseed Rape. International journal of molecular sciences. 2023 Jul; 24(14):. doi: 10.3390/ijms241411402. [PMID: 37511158]
  • Kariyemu Aihaiti, Jun Li, Saimijiang Yaermaimaiti, Qiang Yin, Haji Akber Aisa. A new macrocyclic spermidine alkaloid from the aerial part of Hyssopus cuspidatus Boriss. Natural product research. 2023 Jul; 37(13):2113-2119. doi: 10.1080/14786419.2022.2027935. [PMID: 35045780]
  • Tao Liu, Ning Qiao, Fangjian Ning, Xueyong Huang, Liping Luo. Identification and characterization of plant-derived biomarkers and physicochemical variations in the maturation process of Triadica cochinchinensis honey based on UPLC-QTOF-MS metabolomics analysis. Food chemistry. 2023 May; 408(?):135197. doi: 10.1016/j.foodchem.2022.135197. [PMID: 36527917]
  • Muhammad Zubair Siddiqi, Govindan Rajivgandhi, Soon-Youl Lee, Wan-Taek Im. Characterization of four novel bacterial species of the genus Sphingomonas, Sphingomonas anseongensis, Sphingomonas alba, Sphingomonas brevis and Sphingomonas hankyongi sp.nov., isolated from wet land. International journal of systematic and evolutionary microbiology. 2023 May; 73(5):. doi: 10.1099/ijsem.0.005884. [PMID: 37216283]
  • Bing Yan, Xinjie Mao, Shasha Hu, Shimin Wang, Xiaochen Liu, Jing Sun. Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways. International immunopharmacology. 2023 Apr; 119(?):110166. doi: 10.1016/j.intimp.2023.110166. [PMID: 37104918]
  • Marko Kebert, Saša Kostić, Srđan Stojnić, Eleonora Čapelja, Anđelina Gavranović Markić, Martina Zorić, Lazar Kesić, Victor Flors. A Fine-Tuning of the Plant Hormones, Polyamines and Osmolytes by Ectomycorrhizal Fungi Enhances Drought Tolerance in Pedunculate Oak. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24087510. [PMID: 37108671]
  • Ben-Xue Chen, Yan-Bing Li, Huai-Pan Liu, Ronald Kurtenbach. Putrescine transformation to other forms of polyamines in filling grain embryos functioned in enhancing the resistance of maize plants to drought stress. Plant physiology and biochemistry : PPB. 2023 Apr; 197(?):107654. doi: 10.1016/j.plaphy.2023.107654. [PMID: 36989984]
  • Jiangtao Qiao, Zhouxu Feng, Yong Zhang, Xingying Xiao, Jie Dong, Eric Haubruge, Hongcheng Zhang. Phenolamide and flavonoid glycoside profiles of 20 types of monofloral bee pollen. Food chemistry. 2023 Mar; 405(Pt A):134800. doi: 10.1016/j.foodchem.2022.134800. [PMID: 36347200]
  • Hanna Fuchs, Beata P Plitta-Michalak, Arleta Małecka, Liliana Ciszewska, Łukasz Sikorski, Aleksandra M Staszak, Marcin Michalak, Ewelina Ratajczak. The chances in the redox priming of nondormant recalcitrant seeds by spermidine. Tree physiology. 2023 Mar; ?(?):. doi: 10.1093/treephys/tpad036. [PMID: 36943301]
  • Jian Sun, Jiyu Xu, Yong Liu, Yitong Lin, Fengge Wang, Yue Han, Shumin Zhang, Xiaoyan Gao, Changqing Xu, Hui Yuan. Exogenous spermidine alleviates diabetic cardiomyopathy via suppressing ROS, ERS and Pannexin-1-mediated ferroptosis. Biomolecules and biomedicine. 2023 Mar; ?(?):. doi: 10.17305/bb.2022.8846. [PMID: 36946337]
  • Dongmei Jiang, Yongni Guo, Chunyang Niu, Shiyun Long, Yilong Jiang, Zelong Wang, Xin Wang, Qian Sun, Weikang Ling, Xiaoguang An, Chengweng Ji, Hua Zhao, Bo Kang. Exploration of the Antioxidant Effect of Spermidine on the Ovary and Screening and Identification of Differentially Expressed Proteins. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065793. [PMID: 36982867]
  • Leandro Solmi, Franco R Rossi, Fernando M Romero, Marcel Bach-Pages, Gail M Preston, Oscar A Ruiz, Andrés Gárriz. Polyamine-mediated mechanisms contribute to oxidative stress tolerance in Pseudomonas syringae. Scientific reports. 2023 Mar; 13(1):4279. doi: 10.1038/s41598-023-31239-x. [PMID: 36922543]
  • Boyun Shi, Wei Wang, Mengting Ye, Min Liang, Ziyu Yu, Yingying Zhang, Zhaoyu Liu, Xue Liang, Jian Ao, Fengfeng Xu, Guibin Xu, Xianhan Jiang, Xinke Zhou, Leyuan Liu. Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S. Liver international : official journal of the International Association for the Study of the Liver. 2023 Mar; ?(?):. doi: 10.1111/liv.15558. [PMID: 36892418]
  • Yuna Park, Qingzhen Liu, Soohyun Maeng, Hyejin Oh, Chan-Seok Yun, Hanna Choe, Hyang Burm Lee, Wan-Taek Im. Sphingomonas cremea sp. nov., isolated from ginseng soil. International journal of systematic and evolutionary microbiology. 2023 Mar; 73(3):. doi: 10.1099/ijsem.0.005796. [PMID: 37000168]
  • Jakub Bělíček, Eva Ľuptáková, David Kopečný, Jan Frömmel, Armelle Vigouroux, Sanja Ćavar Zeljković, Franjo Jagic, Pierre Briozzo, David Jaroslav Kopečný, Petr Tarkowski, Jaroslav Nisler, Nuria De Diego, Solange Moréra, Martina Kopečná. Biochemical and structural basis of polyamine, lysine and ornithine acetylation catalyzed by spermine/spermidine N-acetyl transferase in moss and maize. The Plant journal : for cell and molecular biology. 2023 Feb; ?(?):. doi: 10.1111/tpj.16148. [PMID: 36786691]
  • Salika Ramazan, Ifra Nazir, Waseem Yousuf, Riffat John. Environmental stress tolerance in maize (Zea mays): role of polyamine metabolism. Functional plant biology : FPB. 2023 02; 50(2):85-96. doi: 10.1071/fp21324. [PMID: 35300784]
  • Foziya Altaf, Shazia Parveen, Sumira Farooq, Aehsan Ul Haq, Mohammad Lateef Lone, Inayatullah Tahir, Prashant Kaushik, Hamed A El-Serehy. Polyamines effectively mitigate senescence in persistent leaves of Berginia ciliata - a novel model system. Functional plant biology : FPB. 2023 02; 50(2):136-145. doi: 10.1071/fp21273. [PMID: 35144727]
  • Riti Thapar Kapoor, Daniel Ingo Hefft, Ajaz Ahmad. Nitric oxide and spermidine alleviate arsenic-incited oxidative damage in Cicer arietinum by modulating glyoxalase and antioxidant defense system. Functional plant biology : FPB. 2023 02; 50(2):108-120. doi: 10.1071/fp21196. [PMID: 34794540]
  • Jayita Saha, Dwaipayan Chaudhuri, Anirban Kundu, Saswati Bhattacharya, Sudipta Roy, Kalyan Giri. Phylogenetic, structural, functional characterisation and effect of exogenous spermidine on rice (Oryza sativa) HAK transporters under salt stress. Functional plant biology : FPB. 2023 Feb; 50(2):160-182. doi: 10.1071/fp22059. [PMID: 36031595]
  • Dongdong Cao, Yutao Huang, Gaofu Mei, Sheng Zhang, Huaping Wu, Tiyuan Zhao. Spermidine enhances chilling tolerance of kale seeds by modulating ROS and phytohormone metabolism. PloS one. 2023; 18(8):e0289563. doi: 10.1371/journal.pone.0289563. [PMID: 37535595]
  • Xu Chao, Tang Yuqing, Liu Xincheng, Yang Huidong, Wang Yuting, Hu Zhongdong, Hu Xinlong, Liu Buchun, Su Jing. Exogenous spermidine enhances the photosynthetic and antioxidant capacity of citrus seedlings under high temperature. Plant signaling & behavior. 2022 12; 17(1):2086372. doi: 10.1080/15592324.2022.2086372. [PMID: 35703340]
  • Hemanjali Mude, Aniket Balapure, Anindita Thakur, Ramakrishnan Ganesan, Jayati Ray Dutta. Enhanced antibacterial, antioxidant and anticancer activity of caffeic acid by simple acid-base complexation with spermine/spermidine. Natural product research. 2022 Dec; 36(24):6453-6458. doi: 10.1080/14786419.2022.2038597. [PMID: 35142575]
  • Qiqi Lin, Jiahui Huang, Zhiqing Liu, Qunyi Chen, Xinbo Wang, Guohui Yu, Ping Cheng, Lian-Hui Zhang, Zeling Xu. tRNA modification enzyme MiaB connects environmental cues to activation of Pseudomonas aeruginosa type III secretion system. PLoS pathogens. 2022 12; 18(12):e1011027. doi: 10.1371/journal.ppat.1011027. [PMID: 36469533]
  • Xu Pan, Junlong Meng, Lijing Xu, Mingchang Chang, Cuiping Feng, Xueran Geng, Yanfen Cheng, Dongdong Guo, Rongzhu Liu, Zhichao Wang, Dongjie Li, Lirui Tan. In-depth investigation of the hypoglycemic mechanism of Morchella importuna polysaccharide via metabonomics combined with 16S rRNA sequencing. International journal of biological macromolecules. 2022 Nov; 220(?):659-670. doi: 10.1016/j.ijbiomac.2022.08.117. [PMID: 35995180]
  • Zerun Yin, Jinpeng Yu, Xinran Han, Hui Wang, Quangang Yang, Hong Pan, Yanhong Lou, Yuping Zhuge. A novel phytoremediation technology for polluted cadmium soil: Salix integra treated with spermidine and activated carbon. Chemosphere. 2022 Nov; 306(?):135582. doi: 10.1016/j.chemosphere.2022.135582. [PMID: 35803376]
  • Heba Talat Ebeed. Genome-wide analysis of polyamine biosynthesis genes in wheat reveals gene expression specificity and involvement of STRE and MYB-elements in regulating polyamines under drought. BMC genomics. 2022 Oct; 23(1):734. doi: 10.1186/s12864-022-08946-2. [PMID: 36309637]
  • Ken Keefover-Ring, Craig H Carlson, Brennan Hyden, Muhammad Azeem, Lawrence B Smart. Genetic mapping of sexually dimorphic volatile and non-volatile floral secondary chemistry of a dioecious willow. Journal of experimental botany. 2022 10; 73(18):6352-6366. doi: 10.1093/jxb/erac260. [PMID: 35710312]
  • Sophia Pankoke, Christiane Pfarrer, Silke Glage, Christian Mühlfeld, Julia Schipke. Oral Supplementation with the Polyamine Spermidine Affects Hepatic but Not Pulmonary Lipid Metabolism in Lean but Not Obese Mice. Nutrients. 2022 Oct; 14(20):. doi: 10.3390/nu14204318. [PMID: 36297003]
  • Jinyu Gu, Chunmei Hu, Xiangwei Jia, Yanfang Ren, Dongming Su, Junyu He. Physiological and biochemical bases of spermidine-induced alleviation of cadmium and lead combined stress in rice. Plant physiology and biochemistry : PPB. 2022 Oct; 189(?):104-114. doi: 10.1016/j.plaphy.2022.08.010. [PMID: 36081232]
  • Sachie Nakatani, Yasuhiro Horimoto, Natsumi Nakabayashi, Mayumi Karasawa, Masahiro Wada, Kenji Kobata. Spermine Suppresses Adipocyte Differentiation and Exerts Anti-Obesity Effects In Vitro and In Vivo. International journal of molecular sciences. 2022 Oct; 23(19):. doi: 10.3390/ijms231911818. [PMID: 36233120]
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