scyllo-Inositol (BioDeep_00000028174)

Main id: BioDeep_00000003231

Secondary id: BioDeep_00000054926, BioDeep_00000169689, BioDeep_00000410668

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


(1R,2R,3R,4R,5R,6R)-Cyclohexane-1,2,3,4,5,6-hexol

化学式: C6H12O6 (180.0634)
中文名称: D-(+)-手性肌醇, 1L-手性纤维醇, 青蟹肌醇, 粘质肌醇, 表肌醇, 异肌醇, 肌醇, 鲨肌醇
谱图信息: 最多检出来源 not specific(not specific) 0%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

scyllo-Inositol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/scyllo-inositol (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000028174). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1(C(C(C(C(C1O)O)O)O)O)O
InChI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H

描述信息

scyllo-Inositol or scyllitol is an inositol isoform. Inositol is a derivative of cyclohexane with six hydroxyl groups, making it a polyol. It also is known as a sugar alcohol, having exactly the same molecular formula as glucose or other hexoses. Inositol exists in nine possible stereoisomers, including scyllo-inositol, myo-inositol (the most abundant), muco-inositol, D-chiro-inositol, L-chiro-inositol, neo-inositol, allo-inositol, epi-inositol, and cis-inositol. scyllo-Inositol was first isolated from the kidneys of fish in 1858 by Staedeler and Freierchs. scyllo-Inositol is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm. It appears to accumulate in a number of human tissues and biofluids through dietary consumption. It has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379). Results reported by Viola et al (PMID: 15340856) suggest that high CSF concentrations of scyllo-inositol can be induced by chronic alcoholism. scyllo-Inositol when fed to transgenic mice that exhibit a memory disease very similar to human Alzheimers disease, can block the accumulation of soluble amyloid-beta (Aβ) plaques in the brain. scyllo-Inositol was found to reverse memory deficits in the mice, reduce the amount of Aβ plaque in the brains of the mice, and reversed other symptoms associated with the presence of Aβ in the brain (PMID: 16767098).
Scyllitol is an isomer of cyclohexanehexol or inositol. It was first isolated from the kidneys of fish in 1858 by Staedeler and Freierchs. Scyllitol is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm. It appears to accumulate in a number of human tissues and biofluids through dietary consumption. It has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379). Results reported by Viola et al (PMID: 15340856) suggest that high CSF concentrations of scyllo-inositol can be induced by chronic alcoholism. scyllo-Inositol (also called "scyllitol") when fed to transgenic mice that exhibit a memory disease very similar to human Alzheimers disease, can block the accumulation of soluble amyloid-beta (Aβ) plaques in the brain. Scyllitol was found to reverse memory deficits in the mice, reduce the amount of Aβ plaque in the brains of the mice, and reversed other symptoms associated with the presence of Aβ in the brain (PMID: 16767098). [HMDB]
C26170 - Protective Agent > C1509 - Neuroprotective Agent
A - Alimentary tract and metabolism > A11 - Vitamins
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
D-chiro-Inositol is an epimer of myo-inositol found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity. D-chiro-Inositol is used clinically for the treatment of polycystic ovary syndrome (PCOS) and diabetes mellitus, which can reduce hyperglycemia and ameliorate insulin resistance[1][2][3].
i-Inositol is a chemical compound related to lipids found in many foods, especially fruits such as cantaloupe and oranges.
i-Inositol is a chemical compound related to lipids found in many foods, especially fruits such as cantaloupe and oranges.
Scyllo-Inositol, an amyloid inhibitor, potentialy inhibits α-synuclein aggregation. Scyllo-Inositol stabilizes a non-fibrillar non-toxic form of amyloid-β peptide (Aβ42) in vitro, reverses cognitive deficits, and reduces synaptic toxicity and lowers amyloid plaques in an Alzheimer's disease mouse model[1].
Scyllo-Inositol, an amyloid inhibitor, potentialy inhibits α-synuclein aggregation. Scyllo-Inositol stabilizes a non-fibrillar non-toxic form of amyloid-β peptide (Aβ42) in vitro, reverses cognitive deficits, and reduces synaptic toxicity and lowers amyloid plaques in an Alzheimer's disease mouse model[1].

同义名列表

20 个代谢物同义名

(1R,2R,3R,4R,5R,6R)-Cyclohexane-1,2,3,4,5,6-hexol; 1,2,3,4,5,6-Cyclohexanehexol; 1,3,5/2,4,6-cyclohexanehexol; Scyllo-cyclohexanehexol; L-(−)-chiro-Inositol; D-(+)-CHIRO-INOSITOL; scyllo-Inositol; allo-Inositol; muco-Inositol; epi-Inositol; Quercinitol; Cocositol; Scyllitol; inositol; D-chiro-Inositol; myo-Inositol; meso-Inositol; i-Inositol; scyllo-Inositol; Inositol



数据库引用编号

50 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(13)

BioCyc(36)

PlantCyc(23)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

138 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKR1B1, ALB, GFAP, INPP5D, MTOR, PIK3CA, PIK3R6, PLEK, PTEN, TNK1
Peripheral membrane protein 4 INPP5D, MTOR, PIK3R6, TNK1
Endoplasmic reticulum membrane 3 CD4, HSP90B1, MTOR
Nucleus 6 ALB, HSP90B1, INPPL1, MTOR, PLCZ1, PTEN
cytosol 13 AKR1B1, ALB, GFAP, HSP90B1, INPP5D, INPPL1, MTOR, PIK3CA, PIK3R6, PLCZ1, PLEK, PRKCQ, PTEN
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 ALB
nucleoplasm 5 AKR1B1, ATP2B1, MTOR, PLCZ1, PTEN
Cell membrane 6 ATP2B1, CD4, INPP5D, PIK3R6, SLC6A12, TNF
Cytoplasmic side 1 MTOR
lamellipodium 2 INPPL1, PIK3CA
ruffle membrane 1 PLEK
Multi-pass membrane protein 2 ATP2B1, SLC6A12
Golgi apparatus membrane 1 MTOR
Synapse 1 ATP2B1
cell surface 1 TNF
glutamatergic synapse 1 ATP2B1
Golgi apparatus 2 ALB, INPPL1
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 1 TNF
presynaptic membrane 1 ATP2B1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 INPPL1
Lysosome 1 MTOR
Presynapse 1 SLC6A12
plasma membrane 13 ATP2B1, CD4, GCG, GPRIN2, INPP5D, PIK3CA, PIK3R6, PLEK, PRKCQ, PTEN, SLC6A12, TNF, TNK1
synaptic vesicle membrane 1 ATP2B1
Membrane 9 ATP2B1, HSP90B1, INPP5D, INPPL1, MTOR, PIK3R6, PLEK, SLC6A12, TNK1
apical plasma membrane 1 PTEN
basolateral plasma membrane 2 ATP2B1, SLC6A12
extracellular exosome 4 AKR1B1, ALB, ATP2B1, HSP90B1
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 ALB, HSP90B1
extracellular space 4 AKR1B1, ALB, GCG, TNF
perinuclear region of cytoplasm 3 HSP90B1, PIK3CA, PLCZ1
intercalated disc 1 PIK3CA
mitochondrion 1 AKR1B1
protein-containing complex 2 ALB, HSP90B1
intracellular membrane-bounded organelle 1 ATP2B1
Microsome membrane 1 MTOR
filopodium 1 INPPL1
postsynaptic density 1 PTEN
pronucleus 1 PLCZ1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 CD4
Secreted 2 ALB, GCG
extracellular region 6 ALB, GCG, HSP90B1, PLEK, PTEN, TNF
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
astrocyte end-foot 1 GFAP
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 CD4, TNF
dendritic spine 1 PTEN
nucleolus 1 PLCZ1
midbody 1 HSP90B1
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, lamellipodium 1 INPPL1
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 3 CD4, INPP5D, TNF
Cytoplasm, cytoskeleton 1 INPP5D
focal adhesion 1 HSP90B1
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 2 MTOR, PTEN
PML body 2 MTOR, PTEN
collagen-containing extracellular matrix 1 HSP90B1
intermediate filament 1 GFAP
lateral plasma membrane 1 ATP2B1
nuclear speck 1 INPPL1
Cell projection, filopodium 1 INPPL1
Cell projection, neuron projection 1 PTEN
neuron projection 1 PTEN
ciliary basal body 1 ALB
cell projection 4 ATP2B1, GFAP, PTEN, SLC6A12
phagocytic cup 1 TNF
cytoskeleton 1 INPP5D
centriole 1 ALB
spindle pole 2 ALB, INPPL1
blood microparticle 1 ALB
Basolateral cell membrane 2 ATP2B1, SLC6A12
Cytoplasm, cytoskeleton, spindle pole 1 INPPL1
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
Melanosome 1 HSP90B1
Nucleus speckle 1 INPPL1
Presynaptic cell membrane 1 ATP2B1
cell body 1 GFAP
sperm plasma membrane 1 HSP90B1
intermediate filament cytoskeleton 1 GFAP
basal plasma membrane 1 INPPL1
secretory granule lumen 1 GCG
endoplasmic reticulum lumen 4 ALB, CD4, GCG, HSP90B1
platelet alpha granule lumen 1 ALB
phosphatidylinositol 3-kinase complex 2 PIK3CA, PIK3R6
phosphatidylinositol 3-kinase complex, class IA 2 PIK3CA, PIK3R6
Schmidt-Lanterman incisure 1 PTEN
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 CD4
Sarcoplasmic reticulum lumen 1 HSP90B1
Basal cell membrane 1 INPPL1
Cytoplasmic vesicle, phagosome 1 MTOR
cytoplasmic side of lysosomal membrane 1 GFAP
endocytic vesicle lumen 1 HSP90B1
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
sperm head 1 PLCZ1
endoplasmic reticulum chaperone complex 1 HSP90B1
myelin sheath adaxonal region 1 PTEN
photoreceptor ribbon synapse 1 ATP2B1
[Isoform alpha]: Secreted 1 PTEN
phosphatidylinositol 3-kinase complex, class IB 2 PIK3CA, PIK3R6
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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