Gambogic acid (BioDeep_00000002596)

Main id: BioDeep_00000407856

 

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


(2Z)-4-[12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0²,¹⁵.0²,¹⁹.0⁴,¹³.0⁶,¹¹]docosa-4,6(11),9,12,15-pentaen-19-yl]-2-methylbut-2-enoic acid

化学式: C38H44O8 (628.3036024)
中文名称: 异藤黄酸, 藤黄酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c12c(c(c3c(c1CC=C(C)C)O[C@@]14C(=C[C@H]5C(=O)[C@@]1(OC([C@@H]4C5)(C)C)C/C=C(/C(=O)O)\C)C3=O)O)C=C[C@](O2)(CCC=C(C)C)C
InChI: InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-

描述信息

Isolated from Gamboge resin (exudate of Garcinia morella). Gambogic acid is found in herbs and spices and fruits.
Gambogic acid is found in fruits. Gambogic acid is isolated from Gamboge resin (exudate of Garcinia morella).
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

同义名列表

14 个代谢物同义名

(2Z)-4-[12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0²,¹⁵.0²,¹⁹.0⁴,¹³.0⁶,¹¹]docosa-4,6(11),9,12,15-pentaen-19-yl]-2-methylbut-2-enoic acid; (2Z)-4-[12-Hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0²,¹⁵.0²,¹⁹.0⁴,¹³.0⁶,¹¹]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoate; Isogambogic acid; a-Gambogic acid; gambogoic acid; b-Guttilactone; Cambogic acid; Guttatic acid; gambogic acid; b-Guttiferin; gamboge acid; Guttic acid; Gambogate; Beta-Guttiferrin



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qianyu Zhang, Ying Zhang, Chen Wang, Huan Tang, Ang Ma, Peng Gao, Qiaoli Shi, Guohua Wang, Shengnan Shen, Junzhe Zhang, Fei Xia, Yinhua Zhu, Jigang Wang. Gambogic acid exhibits promising anticancer activity by inhibiting the pentose phosphate pathway in lung cancer mouse model. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155657. doi: 10.1016/j.phymed.2024.155657. [PMID: 38692076]
  • Jinshuai Lan, Li Liu, Wenjun Zhao, Zhe Li, Ruifeng Zeng, Shiyuan Fang, Lixia Chen, Yi Shen, Hai Wei, Tong Zhang, Yue Ding. Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system. Free radical biology & medicine. 2024 Jun; 218(?):26-40. doi: 10.1016/j.freeradbiomed.2024.03.023. [PMID: 38570172]
  • Jiaojiao Li, Dandan Mi, Rujing Wang, Yuke Li, Mengnan Zhao, Sanjun Shi. A lava-inspired proteolytic enzyme therapy on cancer with a PEG-based hydrogel enhances tumor distribution and penetration of liposomes. Journal of nanobiotechnology. 2024 May; 22(1):216. doi: 10.1186/s12951-024-02468-7. [PMID: 38698399]
  • You Li, Wenqi Liao, Wei Huang, Fenglin Liu, Lin Ma, Xiaoping Qian. Mechanism of gambogic acid repressing invasion and metastasis of colorectal cancer by regulating macrophage polarization via tumor cell-derived extracellular vesicle-shuttled miR-21. Drug development research. 2024 Feb; 85(1):e22141. doi: 10.1002/ddr.22141. [PMID: 38349264]
  • Xu Wen, Dian Li, Peng Chen, Ming Tan, Hui Zhang, Yuting Liu, Jihua Ren, Shengtao Cheng. Gambogic acid inhibits HBx-mediated hepatitis B virus replication by targeting the DTX1-Notch signaling pathway. Virus research. 2024 Jan; 339(?):199273. doi: 10.1016/j.virusres.2023.199273. [PMID: 38029800]
  • Mengting Da, Su Li, Rui Yang, Zhen Jia, Yulian Ma, Fengxian Qi, Jiuda Zhao, Guoshuang Shen, Daozhen Chen. Therapeutic effect and metabolic fingerprinting of triple-negative breast cancer cells following exposure to a novel pH-responsive, gambogic acid-loaded micelle. Nanotechnology. 2023 Dec; 35(11):. doi: 10.1088/1361-6528/ad1448. [PMID: 38081078]
  • Ang Cai, Pengfei Xia, Xiaokang Zhou, Yao He, Jun Lv. MiR-1275 Targeting SPARC Promotes Gambogic Acid-Induced Inhibition of Gastric Cancer. Biochemical genetics. 2023 Apr; ?(?):. doi: 10.1007/s10528-023-10381-1. [PMID: 37118619]
  • Siyan Zhang, Xingyao Zhang, Dong Zhang, Liang Wei, Bin Xiong, Qi Meng, Shougang Jiang. Synergistic effect of docetaxel and gambogic acid on bone metastasis of lung cancer. Bulletin du cancer. 2023 Mar; ?(?):. doi: 10.1016/j.bulcan.2023.02.007. [PMID: 36890055]
  • Fengli Huang, Qun Zhang, Jie Xiao, Xin Zhang, Xingzhi Han, Xiao Shi, Jing Hu, Li Li, Xiaoping Qian. Cancer Cell Membrane-Coated Gambogic Acid Nanoparticles for Effective Anticancer Vaccination by Activating Dendritic Cells. International journal of nanomedicine. 2023; 18(?):2261-2273. doi: 10.2147/ijn.s408521. [PMID: 37159807]
  • Yuling Liu, Xin Nie, Yihan Wu, Longfei Lin, Qian Liao, Jingjing Li, Simon Ming-Yuen Lee, Hui Li, Jinming Zhang. Carrier-Free Gambogic Acid Dimer Self-Assembly Nanomedicines for Rheumatoid Arthritis Treatment. International journal of nanomedicine. 2023; 18(?):5457-5472. doi: 10.2147/ijn.s422096. [PMID: 37771407]
  • Song Lyu, Xue Zhang, Zhenzhen Tu, Haisheng Zhou, Xisong Ke, Yi Qu. GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer. Pharmacological research. 2022 08; 182(?):106279. doi: 10.1016/j.phrs.2022.106279. [PMID: 35659621]
  • Nutchanard Khunpatee, Kanit Bhukhai, Varanuj Chatsudthipong, Chaowalit Yuajit. Potential Application of Gambogic Acid for Retarding Renal Cyst Progression in Polycystic Kidney Disease. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123837. [PMID: 35744960]
  • Tao Ren, Xian-Yu Bai, Meng-Zhe Yang, Ning Xu, Xing-Zhe Guo, Liu-Jie Qin, Zhi-Lin Huang, Qiong-Yao Zhong, Yuan-Jiao Huang, Wen-Zhen Lin, Ai-Jun Jiao, Bei-Bei Zhang. Gambogic acid suppresses nasopharyngeal carcinoma via rewiring molecular network of cancer malignancy and immunosurveillance. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113012. doi: 10.1016/j.biopha.2022.113012. [PMID: 35658246]
  • Feng Wang, Lei Dong, Simin Liang, Xixi Wei, Yongling Wang, Liansheng Chang, Kang Guo, Hongwei Wu, Yuqiao Chang, Yaling Yin, Lu Wang, Yu Shi, Fei Yan, Nana Li. Ultrasound-triggered drug delivery for glioma therapy through gambogic acid-loaded nanobubble-microbubble complexes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113042. doi: 10.1016/j.biopha.2022.113042. [PMID: 35658212]
  • Jianxin Liu, Shuhao Fan, Yinhong Xiang, Jiaojiao Xia, Hua Jin, Jun-Fa Xu, Fen Yang, Jiye Cai, Jiang Pi. Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy. Scanning. 2022; 2022(?):1422185. doi: 10.1155/2022/1422185. [PMID: 35937670]
  • Ding Zhang, Boqi Chen, Qingke Mu, Wei Wang, Kaili Liang, Liyan Wang, Qing Wang. Topical delivery of gambogic acid assisted by the combination of low-frequency ultrasound and chemical enhancers for chemotherapy of cutaneous melanoma. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Nov; 166(?):105975. doi: 10.1016/j.ejps.2021.105975. [PMID: 34391880]
  • Zhixin Zhang, Lili Liang, Gang Cao. Critical role of miR-26a-5p/Wnt5a signaling in gambogic acid-induced inhibition of gastric cancer. Journal of biochemical and molecular toxicology. 2021 Apr; 35(4):e22721. doi: 10.1002/jbt.22721. [PMID: 33533530]
  • Zhoujiang Chen, Guanghui Hong, Zhiyan Liu, Dayun Yang, Ranjith Kumar Kankala, Wenguo Wu. Synergistic antitumor efficacy of doxorubicin and gambogic acid-encapsulated albumin nanocomposites. Colloids and surfaces. B, Biointerfaces. 2020 Dec; 196(?):111286. doi: 10.1016/j.colsurfb.2020.111286. [PMID: 32768988]
  • Tongtong Wang, Jing Du, Dexia Kong, Guosheng Yang, Qihao Zhou, Fei You, Yan Lin, Ying Wang. Gambogic acid inhibits proliferation and induces apoptosis of human acute T‑cell leukemia cells by inducing autophagy and downregulating β‑catenin signaling pathway: Mechanisms underlying the effect of Gambogic acid on T‑ALL cells. Oncology reports. 2020 10; 44(4):1747-1757. doi: 10.3892/or.2020.7726. [PMID: 32945501]
  • Zhe Ma, Nan Li, Bing Zhang, YuYu Hui, Ying Zhang, Peng Lu, Jiaxin Pi, Zhidong Liu. Dual drug-loaded nano-platform for targeted cancer therapy: toward clinical therapeutic efficacy of multifunctionality. Journal of nanobiotechnology. 2020 Sep; 18(1):123. doi: 10.1186/s12951-020-00681-8. [PMID: 32887626]
  • Elham Hatami, Meena Jaggi, Subhash C Chauhan, Murali M Yallapu. Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics. Biochimica et biophysica acta. Reviews on cancer. 2020 08; 1874(1):188381. doi: 10.1016/j.bbcan.2020.188381. [PMID: 32492470]
  • Pei Wang, Fuquan Jiang, Biaoqi Chen, Hanxiao Tang, Xiaojiao Zeng, Duanhua Cai, Mingzhi Zhu, Ruimin Long, Dayun Yang, Ranjith Kumar Kankala, Shibin Wang, Yuangang Liu. Bioinspired red blood cell membrane-encapsulated biomimetic nanoconstructs for synergistic and efficacious chemo-photothermal therapy. Colloids and surfaces. B, Biointerfaces. 2020 May; 189(?):110842. doi: 10.1016/j.colsurfb.2020.110842. [PMID: 32058253]
  • Yuling Liu, Yingchong Chen, Longfei Lin, Hui Li. Gambogic Acid as a Candidate for Cancer Therapy: A Review. International journal of nanomedicine. 2020; 15(?):10385-10399. doi: 10.2147/ijn.s277645. [PMID: 33376327]
  • Chun-Yu Li, Qi Wang, Xiao-Min Wang, Guo-Xia Li, Shen Shen, Xiao-Lu Wei. Gambogic acid exhibits anti-metastatic activity on malignant melanoma mainly through inhibition of PI3K/Akt and ERK signaling pathways. European journal of pharmacology. 2019 Dec; 864(?):172719. doi: 10.1016/j.ejphar.2019.172719. [PMID: 31586634]
  • Yonghui Wang, Yana Sui, Yinggang Tao. Gambogic acid increases the sensitivity to paclitaxel in drug‑resistant triple‑negative breast cancer via the SHH signaling pathway. Molecular medicine reports. 2019 Nov; 20(5):4515-4522. doi: 10.3892/mmr.2019.10697. [PMID: 31545492]
  • Yilin Song, Yule Wang, Yan Zhu, Yu Cheng, Yidan Wang, Siyu Wang, Fengping Tan, Fan Lian, Nan Li. Biomodal Tumor-Targeted and Redox-Responsive Bi2 Se3 Hollow Nanocubes for MSOT/CT Imaging Guided Synergistic Low-Temperature Photothermal Radiotherapy. Advanced healthcare materials. 2019 08; 8(16):e1900250. doi: 10.1002/adhm.201900250. [PMID: 31290616]
  • Zhenlong Yu, Yanan Jv, Lu Cai, Xiangge Tian, Xiaokui Huo, Chao Wang, Baojing Zhang, ChengPeng Sun, Jing Ning, Lei Feng, Houli Zhang, Xiaochi Ma. Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90. Toxicology and applied pharmacology. 2019 05; 371(?):63-73. doi: 10.1016/j.taap.2019.03.028. [PMID: 30953615]
  • Li Wan, Qun Zhang, Sheng Wang, Yong Gao, Xiaofei Chen, Yang Zhao, Xiaoping Qian. Gambogic acid impairs tumor angiogenesis by targeting YAP/STAT3 signaling axis. Phytotherapy research : PTR. 2019 May; 33(5):1579-1591. doi: 10.1002/ptr.6350. [PMID: 31033039]
  • Dereje Kebebe, Yumei Wu, Bing Zhang, Jian Yang, Yuanyuan Liu, Xinyue Li, Zhe Ma, Peng Lu, Zhidong Liu, Jiawei Li. Dimeric c(RGD) peptide conjugated nanostructured lipid carriers for efficient delivery of Gambogic acid to breast cancer. International journal of nanomedicine. 2019; 14(?):6179-6195. doi: 10.2147/ijn.s202424. [PMID: 31447559]
  • Lili Liang, Zhixin Zhang, Xiaowei Qin, Ying Gao, Peng Zhao, Jing Liu, Weihui Zeng. Gambogic Acid Inhibits Melanoma through Regulation of miR-199a-3p/ZEB1 Signalling. Basic & clinical pharmacology & toxicology. 2018 Dec; 123(6):692-703. doi: 10.1111/bcpt.13090. [PMID: 29959879]
  • Rui Huang, Jiawei Li, Dereje Kebebe, Yumei Wu, Bing Zhang, Zhidong Liu. Cell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment. Drug delivery. 2018 Nov; 25(1):757-765. doi: 10.1080/10717544.2018.1446474. [PMID: 29528244]
  • Yan Zhang, Xinyi Tan, Tianyang Ren, Chao Jia, Zaixing Yang, Hong Sun. Folate-modified carboxymethyl-chitosan/polyethylenimine/bovine serum albumin based complexes for tumor site-specific drug delivery. Carbohydrate polymers. 2018 Oct; 198(?):76-85. doi: 10.1016/j.carbpol.2018.06.055. [PMID: 30093044]
  • Zhongcheng Ke, Lei Yang, Hao Wu, Zihao Li, Xiaobin Jia, Zhenghai Zhang. Evaluation of in vitro and in vivo antitumor effects of gambogic acid-loaded layer-by-layer self-assembled micelles. International journal of pharmaceutics. 2018 Jul; 545(1-2):306-317. doi: 10.1016/j.ijpharm.2018.04.016. [PMID: 29654896]
  • Wei-Lun Tang, Wei-Hsin Tang, Andras Szeitz, Jayesh Kulkarni, Pieter Cullis, Shyh-Dar Li. Systemic study of solvent-assisted active loading of gambogic acid into liposomes and its formulation optimization for improved delivery. Biomaterials. 2018 06; 166(?):13-26. doi: 10.1016/j.biomaterials.2018.03.004. [PMID: 29529479]
  • Qing Yue, Frank Stahl, Oliver Plettenburg, Andreas Kirschning, Athanasia Warnecke, Carsten Zeilinger. The Noncompetitive Effect of Gambogic Acid Displaces Fluorescence-Labeled ATP but Requires ATP for Binding to Hsp90/HtpG. Biochemistry. 2018 05; 57(18):2601-2605. doi: 10.1021/acs.biochem.8b00155. [PMID: 29664615]
  • Fan Yu, Fuguang Jiang, Xinhui Tang, Bochu Wang. N-octyl-N-arginine-chitosan micelles for gambogic acid intravenous delivery: characterization, cell uptake, pharmacokinetics, and biodistribution. Drug development and industrial pharmacy. 2018 Apr; 44(4):615-623. doi: 10.1080/03639045.2017.1405973. [PMID: 29188736]
  • Qing Lai Wang, Dong Zhen Yang, Cunxian Lv. Anti‑inflammatory effects of gambogic acid in murine collagen‑induced arthritis through PI3K/Akt signaling pathway. Molecular medicine reports. 2018 03; 17(3):4791-4796. doi: 10.3892/mmr.2018.8389. [PMID: 29328461]
  • Yanan Kang, Lu Lu, Jinshuai Lan, Yue Ding, Jing Yang, Yong Zhang, Yuan Zhao, Tong Zhang, Rodney J Y Ho. Redox-responsive polymeric micelles formed by conjugating gambogic acid with bioreducible poly(amido amine)s for the co-delivery of docetaxel and MMP-9 shRNA. Acta biomaterialia. 2018 03; 68(?):137-153. doi: 10.1016/j.actbio.2017.12.028. [PMID: 29288085]
  • Zhen Zhang, Hanqing Qian, Jie Huang, Huizi Sha, Hang Zhang, Lixia Yu, Baorui Liu, Dong Hua, Xiaoping Qian. Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal cancer treatment. International journal of nanomedicine. 2018; 13(?):4961-4975. doi: 10.2147/ijn.s170148. [PMID: 30214200]
  • Dinghu Zhang, Zhengyun Zou, Wei Ren, Hanqing Qian, Qianfeng Cheng, Liulian Ji, Baorui Liu, Qin Liu. Gambogic acid-loaded PEG-PCL nanoparticles act as an effective antitumor agent against gastric cancer. Pharmaceutical development and technology. 2018 Jan; 23(1):33-40. doi: 10.1080/10837450.2017.1295068. [PMID: 29069711]
  • Shengpeng Wang, Min Shao, Zhangfeng Zhong, Anqi Wang, Jiliang Cao, Yucong Lu, Yitao Wang, Jinming Zhang. Co-delivery of gambogic acid and TRAIL plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles for the treatment of triple negative breast cancer. Drug delivery. 2017 Nov; 24(1):1791-1800. doi: 10.1080/10717544.2017.1406558. [PMID: 29172759]
  • Teng Zhao, Hong-Jian Wang, Wen-Wen Zhao, Yi-Ling Sun, Li-Kuan Hu. Gambogic acid improves non-small cell lung cancer progression by inhibition of mTOR signaling pathway. The Kaohsiung journal of medical sciences. 2017 Nov; 33(11):543-549. doi: 10.1016/j.kjms.2017.06.013. [PMID: 29050671]
  • Jingya Ruan, Chang Zheng, Yanxia Liu, Lu Qu, Haiyang Yu, Lifeng Han, Yi Zhang, Tao Wang. Chemical and Biological Research on Herbal Medicines Rich in Xanthones. Molecules (Basel, Switzerland). 2017 Oct; 22(10):. doi: 10.3390/molecules22101698. [PMID: 29019929]
  • Abhishek Shetty, Thejaswini Venkatesh, Padmanaban S Suresh, Rie Tsutsumi. Exploration of acute genotoxic effects and antigenotoxic potential of gambogic acid using Allium cepa assay. Plant physiology and biochemistry : PPB. 2017 Sep; 118(?):643-652. doi: 10.1016/j.plaphy.2017.08.005. [PMID: 28806720]
  • Yan Zhang, Zhijie Yang, Xinyi Tan, Xing Tang, Zaixing Yang. Development of a More Efficient Albumin-Based Delivery System for Gambogic Acid with Low Toxicity for Lung Cancer Therapy. AAPS PharmSciTech. 2017 Aug; 18(6):1987-1997. doi: 10.1208/s12249-016-0670-4. [PMID: 27933587]
  • Xuefei Yan, Ye Yang, Liqin He, Daiyin Peng, Dengke Yin. Gambogic acid grafted low molecular weight heparin micelles for targeted treatment in a hepatocellular carcinoma model with an enhanced anti-angiogenesis effect. International journal of pharmaceutics. 2017 Apr; 522(1-2):110-118. doi: 10.1016/j.ijpharm.2017.02.051. [PMID: 28242375]
  • Zhen Zhang, Hanqing Qian, Mi Yang, Rutian Li, Jing Hu, Li Li, Lixia Yu, Baorui Liu, Xiaoping Qian. Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment. International journal of nanomedicine. 2017; 12(?):1593-1605. doi: 10.2147/ijn.s127256. [PMID: 28280328]
  • Yiqing Zhou, Weichao Li, Xixi Zhang, Haibing Zhang, Youli Xiao. Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics. Chemical communications (Cambridge, England). 2016 Nov; 52(97):14035-14038. doi: 10.1039/c6cc07581a. [PMID: 27853763]
  • Mohammad Ishaq, Rani Ojha, Kapil Sharma, Gaurav Sharma, Shrawan K Singh, Sekhar Majumdar. Functional inhibition of Hsp70 by Pifithrin-μ switches Gambogic acid induced caspase dependent cell death to caspase independent cell death in human bladder cancer cells. Biochimica et biophysica acta. 2016 11; 1863(11):2560-2573. doi: 10.1016/j.bbamcr.2016.07.001. [PMID: 27395830]
  • Yubei Qu, Guanghua Zhang, Yunxia Ji, Haibo Zhua, Changjun Lv, Wanglin Jiang. Protective role of gambogic acid in experimental pulmonary fibrosis in vitro and in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Apr; 23(4):350-8. doi: 10.1016/j.phymed.2016.01.011. [PMID: 27002405]
  • Fan Yu, Xinhui Tang. Novel Long-Circulating Liposomes Consisting of PEG Modified β-Sitosterol for Gambogic Acid Delivery. Journal of nanoscience and nanotechnology. 2016 Mar; 16(3):3115-21. doi: 10.1166/jnn.2016.12405. [PMID: 27455771]
  • Yang Wu, Laura N Cruz, Tadge Szestak, Gavin Laing, Gemma R Molyneux, Celia R S Garcia, Alister G Craig. An external sensing system in Plasmodium falciparum-infected erythrocytes. Malaria journal. 2016 Feb; 15(?):103. doi: 10.1186/s12936-016-1144-6. [PMID: 26893139]
  • Qingxi Yue, Lixing Feng, Biyin Cao, Miao Liu, Dongmei Zhang, Wanying Wu, Baohong Jiang, Min Yang, Xuan Liu, Dean Guo. Proteomic Analysis Revealed the Important Role of Vimentin in Human Cervical Carcinoma HeLa Cells Treated With Gambogic Acid. Molecular & cellular proteomics : MCP. 2016 Jan; 15(1):26-44. doi: 10.1074/mcp.m115.053272. [PMID: 26499837]
  • Ying Xu, JinBao Liu, YingLi Wu, QingLong Guo, HanDong Sun, GuoQiang Chen. Natural products against hematological malignancies and identification of their targets. Science China. Life sciences. 2015 Dec; 58(12):1191-201. doi: 10.1007/s11427-015-4922-4. [PMID: 26566803]
  • Zhifen Zheng, Wanglu Ou, Xinshi Zhang, Yongzhi Li, Yujuan Li. UHPLC-MS method for determination of gambogic acid and application to bioavailability, pharmacokinetics, excretion and tissue distribution in rats. Biomedical chromatography : BMC. 2015 Oct; 29(10):1581-8. doi: 10.1002/bmc.3462. [PMID: 25828810]
  • Jinhao Chen, Min Zhou, Qian Zhang, Jingyan Xu, Jian Ouyang. Anticancer Effect and Apoptosis Induction of Gambogic Acid in Human Leukemia Cell Line K562 In Vitro. Medical science monitor : international medical journal of experimental and clinical research. 2015 Jun; 21(?):1604-10. doi: 10.12659/msm.893004. [PMID: 26049398]
  • Xiangdong Hua, Chuang Liang, Lei Dong, Xiaotong Qu, Tong Zhao. Simultaneous determination and pharmacokinetic study of gambogic acid and gambogenic acid in rat plasma after oral administration of Garcinia hanburyi extracts by LC-MS/MS. Biomedical chromatography : BMC. 2015 Apr; 29(4):545-51. doi: 10.1002/bmc.3311. [PMID: 25159917]
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