Gambogic acid (BioDeep_00000002596)

Main id: BioDeep_00000407856

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(2Z)-4-[12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0²,¹⁵.0²,¹⁹.0⁴,¹³.0⁶,¹¹]docosa-4,6(11),9,12,15-pentaen-19-yl]-2-methylbut-2-enoic acid

化学式: C38H44O8 (628.3036)
中文名称: 异藤黄酸, 藤黄酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c12c(c(c3c(c1CC=C(C)C)O[C@@]14C(=C[C@H]5C(=O)[C@@]1(OC([C@@H]4C5)(C)C)C/C=C(/C(=O)O)\C)C3=O)O)C=C[C@](O2)(CCC=C(C)C)C
InChI: InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-

描述信息

Isolated from Gamboge resin (exudate of Garcinia morella). Gambogic acid is found in herbs and spices and fruits.
Gambogic acid is found in fruits. Gambogic acid is isolated from Gamboge resin (exudate of Garcinia morella).
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

同义名列表

15 个代谢物同义名

(2Z)-4-[12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0²,¹⁵.0²,¹⁹.0⁴,¹³.0⁶,¹¹]docosa-4,6(11),9,12,15-pentaen-19-yl]-2-methylbut-2-enoic acid; (2Z)-4-[12-Hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0²,¹⁵.0²,¹⁹.0⁴,¹³.0⁶,¹¹]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoate; Isogambogic acid; a-Gambogic acid; gambogoic acid; b-Guttilactone; Cambogic acid; Guttatic acid; gambogic acid; b-Guttiferin; gamboge acid; Guttic acid; Gambogate; Beta-Guttiferrin; Gambogic acid



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

31 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, AKT1, ALB, ANG, BCL2, CASP3, EGFR, MDM2, MTOR, NFKB1, PIK3CA, TP53, VEGFA
Peripheral membrane protein 1 MTOR
Endosome membrane 3 EGFR, TF, TFRC
Endoplasmic reticulum membrane 4 BCL2, EGFR, HSP90B1, MTOR
Nucleus 13 AKT1, ALB, ANG, BCL2, CASP3, EGFR, HSP90B1, MDM2, MTOR, NFKB1, PARP1, TP53, VEGFA
cytosol 13 AKT1, ALB, ANG, BCL2, CASP3, CD44, HSP90B1, MDM2, MTOR, NFKB1, PARP1, PIK3CA, TP53
dendrite 1 MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 2 ALB, TP53
nucleoplasm 7 AKT1, CASP3, MDM2, MTOR, NFKB1, PARP1, TP53
Cell membrane 6 ABCB1, AKT1, CD44, EGFR, TFRC, TNF
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 MTOR
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 7 ABCB1, CD44, EGFR, TF, TFRC, TNF, VEGFA
glutamatergic synapse 5 AKT1, CASP3, EGFR, MDM2, TFRC
Golgi apparatus 3 ALB, CD44, VEGFA
Golgi membrane 2 EGFR, MTOR
growth cone 1 ANG
lysosomal membrane 1 MTOR
neuronal cell body 3 ANG, CASP3, TNF
postsynapse 1 AKT1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 PARP1
Lysosome 1 MTOR
endosome 2 EGFR, TFRC
plasma membrane 9 ABCB1, AKT1, CD44, EGFR, MDM2, PIK3CA, TF, TFRC, TNF
Membrane 11 ABCB1, AKT1, BCL2, CD44, EGFR, HSP90B1, MTOR, PARP1, TFRC, TP53, VEGFA
apical plasma membrane 4 ABCB1, CD44, EGFR, TF
axon 1 CCK
basolateral plasma membrane 3 CD44, EGFR, TFRC
extracellular exosome 6 ABCB1, ALB, CD44, HSP90B1, TF, TFRC
Lysosome membrane 1 MTOR
endoplasmic reticulum 5 ALB, BCL2, HSP90B1, TP53, VEGFA
extracellular space 8 ALB, ANG, CCK, EGFR, TF, TFRC, TNF, VEGFA
perinuclear region of cytoplasm 5 EGFR, HSP90B1, PIK3CA, TF, TFRC
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, NFKB1, PARP1, TP53
protein-containing complex 8 AKT1, ALB, BCL2, EGFR, HSP90B1, MDM2, PARP1, TP53
intracellular membrane-bounded organelle 1 TFRC
Microsome membrane 1 MTOR
postsynaptic density 2 CASP3, MDM2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 CD44, EGFR
Secreted 6 ALB, ANG, CCK, CD44, TF, VEGFA
extracellular region 10 ALB, ANG, CCK, CD44, HSP90B1, NFKB1, TF, TFRC, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 2 BCL2, CD44
mitochondrial outer membrane 2 BCL2, MTOR
basal part of cell 1 TF
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
anchoring junction 1 ALB
transcription regulator complex 3 NFKB1, PARP1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 2 TFRC, TNF
Extracellular vesicle 1 TFRC
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
cytoplasmic vesicle 2 TF, TFRC
microtubule cytoskeleton 1 AKT1
nucleolus 4 ANG, MDM2, PARP1, TP53
midbody 1 HSP90B1
Early endosome 2 TF, TFRC
cell-cell junction 1 AKT1
clathrin-coated pit 2 TF, TFRC
recycling endosome 3 TF, TFRC, TNF
Single-pass type II membrane protein 2 TFRC, TNF
vesicle 2 AKT1, TF
Apical cell membrane 1 ABCB1
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 3 CD44, EGFR, HSP90B1
spindle 1 AKT1
extracellular matrix 1 VEGFA
basement membrane 1 ANG
intracellular vesicle 1 EGFR
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 VEGFA
Late endosome 1 TF
receptor complex 1 EGFR
ciliary basal body 2 AKT1, ALB
chromatin 3 NFKB1, PARP1, TP53
cell projection 1 CD44
phagocytic cup 1 TNF
Chromosome 2 ANG, PARP1
centriole 1 ALB
Nucleus, nucleolus 3 ANG, MDM2, PARP1
spindle pole 1 ALB
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 3 ALB, TF, TFRC
site of double-strand break 2 PARP1, TP53
nuclear envelope 2 MTOR, PARP1
Recycling endosome membrane 1 TFRC
Endomembrane system 1 MTOR
microvillus 1 CD44
Cell projection, microvillus 1 CD44
Nucleus, nucleoplasm 1 MDM2
Melanosome 2 HSP90B1, TFRC
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
basal plasma membrane 2 EGFR, TF
synaptic membrane 1 EGFR
secretory granule lumen 2 NFKB1, TF
HFE-transferrin receptor complex 2 TF, TFRC
secretory granule membrane 1 CD44
endoplasmic reticulum lumen 3 ALB, HSP90B1, TF
nuclear matrix 1 TP53
transcription repressor complex 2 MDM2, TP53
platelet alpha granule lumen 2 ALB, VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
endocytic vesicle membrane 1 MDM2
endocytic vesicle 2 ANG, TF
clathrin-coated endocytic vesicle membrane 3 EGFR, TF, TFRC
Sarcoplasmic reticulum lumen 1 HSP90B1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 PARP1
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
postsynaptic recycling endosome membrane 1 TFRC
site of DNA damage 1 PARP1
vesicle coat 1 TF
lamellipodium membrane 1 CD44
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 HSP90B1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Transferrin receptor protein 1, serum form]: Secreted 1 TFRC
angiogenin-PRI complex 1 ANG
macrophage migration inhibitory factor receptor complex 1 CD44
endoplasmic reticulum chaperone complex 1 HSP90B1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB
dense body 1 TF
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Qianyu Zhang, Ying Zhang, Chen Wang, Huan Tang, Ang Ma, Peng Gao, Qiaoli Shi, Guohua Wang, Shengnan Shen, Junzhe Zhang, Fei Xia, Yinhua Zhu, Jigang Wang. Gambogic acid exhibits promising anticancer activity by inhibiting the pentose phosphate pathway in lung cancer mouse model. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155657. doi: 10.1016/j.phymed.2024.155657. [PMID: 38692076]
  • Jinshuai Lan, Li Liu, Wenjun Zhao, Zhe Li, Ruifeng Zeng, Shiyuan Fang, Lixia Chen, Yi Shen, Hai Wei, Tong Zhang, Yue Ding. Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system. Free radical biology & medicine. 2024 Jun; 218(?):26-40. doi: 10.1016/j.freeradbiomed.2024.03.023. [PMID: 38570172]
  • Jiaojiao Li, Dandan Mi, Rujing Wang, Yuke Li, Mengnan Zhao, Sanjun Shi. A lava-inspired proteolytic enzyme therapy on cancer with a PEG-based hydrogel enhances tumor distribution and penetration of liposomes. Journal of nanobiotechnology. 2024 May; 22(1):216. doi: 10.1186/s12951-024-02468-7. [PMID: 38698399]
  • You Li, Wenqi Liao, Wei Huang, Fenglin Liu, Lin Ma, Xiaoping Qian. Mechanism of gambogic acid repressing invasion and metastasis of colorectal cancer by regulating macrophage polarization via tumor cell-derived extracellular vesicle-shuttled miR-21. Drug development research. 2024 Feb; 85(1):e22141. doi: 10.1002/ddr.22141. [PMID: 38349264]
  • Xu Wen, Dian Li, Peng Chen, Ming Tan, Hui Zhang, Yuting Liu, Jihua Ren, Shengtao Cheng. Gambogic acid inhibits HBx-mediated hepatitis B virus replication by targeting the DTX1-Notch signaling pathway. Virus research. 2024 Jan; 339(?):199273. doi: 10.1016/j.virusres.2023.199273. [PMID: 38029800]
  • Mengting Da, Su Li, Rui Yang, Zhen Jia, Yulian Ma, Fengxian Qi, Jiuda Zhao, Guoshuang Shen, Daozhen Chen. Therapeutic effect and metabolic fingerprinting of triple-negative breast cancer cells following exposure to a novel pH-responsive, gambogic acid-loaded micelle. Nanotechnology. 2023 Dec; 35(11):. doi: 10.1088/1361-6528/ad1448. [PMID: 38081078]
  • Ang Cai, Pengfei Xia, Xiaokang Zhou, Yao He, Jun Lv. MiR-1275 Targeting SPARC Promotes Gambogic Acid-Induced Inhibition of Gastric Cancer. Biochemical genetics. 2023 Apr; ?(?):. doi: 10.1007/s10528-023-10381-1. [PMID: 37118619]
  • Siyan Zhang, Xingyao Zhang, Dong Zhang, Liang Wei, Bin Xiong, Qi Meng, Shougang Jiang. Synergistic effect of docetaxel and gambogic acid on bone metastasis of lung cancer. Bulletin du cancer. 2023 Mar; ?(?):. doi: 10.1016/j.bulcan.2023.02.007. [PMID: 36890055]
  • Fengli Huang, Qun Zhang, Jie Xiao, Xin Zhang, Xingzhi Han, Xiao Shi, Jing Hu, Li Li, Xiaoping Qian. Cancer Cell Membrane-Coated Gambogic Acid Nanoparticles for Effective Anticancer Vaccination by Activating Dendritic Cells. International journal of nanomedicine. 2023; 18(?):2261-2273. doi: 10.2147/ijn.s408521. [PMID: 37159807]
  • Yuling Liu, Xin Nie, Yihan Wu, Longfei Lin, Qian Liao, Jingjing Li, Simon Ming-Yuen Lee, Hui Li, Jinming Zhang. Carrier-Free Gambogic Acid Dimer Self-Assembly Nanomedicines for Rheumatoid Arthritis Treatment. International journal of nanomedicine. 2023; 18(?):5457-5472. doi: 10.2147/ijn.s422096. [PMID: 37771407]
  • Song Lyu, Xue Zhang, Zhenzhen Tu, Haisheng Zhou, Xisong Ke, Yi Qu. GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer. Pharmacological research. 2022 08; 182(?):106279. doi: 10.1016/j.phrs.2022.106279. [PMID: 35659621]
  • Nutchanard Khunpatee, Kanit Bhukhai, Varanuj Chatsudthipong, Chaowalit Yuajit. Potential Application of Gambogic Acid for Retarding Renal Cyst Progression in Polycystic Kidney Disease. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123837. [PMID: 35744960]
  • Tao Ren, Xian-Yu Bai, Meng-Zhe Yang, Ning Xu, Xing-Zhe Guo, Liu-Jie Qin, Zhi-Lin Huang, Qiong-Yao Zhong, Yuan-Jiao Huang, Wen-Zhen Lin, Ai-Jun Jiao, Bei-Bei Zhang. Gambogic acid suppresses nasopharyngeal carcinoma via rewiring molecular network of cancer malignancy and immunosurveillance. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113012. doi: 10.1016/j.biopha.2022.113012. [PMID: 35658246]
  • Feng Wang, Lei Dong, Simin Liang, Xixi Wei, Yongling Wang, Liansheng Chang, Kang Guo, Hongwei Wu, Yuqiao Chang, Yaling Yin, Lu Wang, Yu Shi, Fei Yan, Nana Li. Ultrasound-triggered drug delivery for glioma therapy through gambogic acid-loaded nanobubble-microbubble complexes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113042. doi: 10.1016/j.biopha.2022.113042. [PMID: 35658212]
  • Jianxin Liu, Shuhao Fan, Yinhong Xiang, Jiaojiao Xia, Hua Jin, Jun-Fa Xu, Fen Yang, Jiye Cai, Jiang Pi. Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy. Scanning. 2022; 2022(?):1422185. doi: 10.1155/2022/1422185. [PMID: 35937670]
  • Ding Zhang, Boqi Chen, Qingke Mu, Wei Wang, Kaili Liang, Liyan Wang, Qing Wang. Topical delivery of gambogic acid assisted by the combination of low-frequency ultrasound and chemical enhancers for chemotherapy of cutaneous melanoma. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Nov; 166(?):105975. doi: 10.1016/j.ejps.2021.105975. [PMID: 34391880]
  • Zhixin Zhang, Lili Liang, Gang Cao. Critical role of miR-26a-5p/Wnt5a signaling in gambogic acid-induced inhibition of gastric cancer. Journal of biochemical and molecular toxicology. 2021 Apr; 35(4):e22721. doi: 10.1002/jbt.22721. [PMID: 33533530]
  • Zhoujiang Chen, Guanghui Hong, Zhiyan Liu, Dayun Yang, Ranjith Kumar Kankala, Wenguo Wu. Synergistic antitumor efficacy of doxorubicin and gambogic acid-encapsulated albumin nanocomposites. Colloids and surfaces. B, Biointerfaces. 2020 Dec; 196(?):111286. doi: 10.1016/j.colsurfb.2020.111286. [PMID: 32768988]
  • Tongtong Wang, Jing Du, Dexia Kong, Guosheng Yang, Qihao Zhou, Fei You, Yan Lin, Ying Wang. Gambogic acid inhibits proliferation and induces apoptosis of human acute T‑cell leukemia cells by inducing autophagy and downregulating β‑catenin signaling pathway: Mechanisms underlying the effect of Gambogic acid on T‑ALL cells. Oncology reports. 2020 10; 44(4):1747-1757. doi: 10.3892/or.2020.7726. [PMID: 32945501]
  • Zhe Ma, Nan Li, Bing Zhang, YuYu Hui, Ying Zhang, Peng Lu, Jiaxin Pi, Zhidong Liu. Dual drug-loaded nano-platform for targeted cancer therapy: toward clinical therapeutic efficacy of multifunctionality. Journal of nanobiotechnology. 2020 Sep; 18(1):123. doi: 10.1186/s12951-020-00681-8. [PMID: 32887626]
  • Elham Hatami, Meena Jaggi, Subhash C Chauhan, Murali M Yallapu. Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics. Biochimica et biophysica acta. Reviews on cancer. 2020 08; 1874(1):188381. doi: 10.1016/j.bbcan.2020.188381. [PMID: 32492470]
  • Pei Wang, Fuquan Jiang, Biaoqi Chen, Hanxiao Tang, Xiaojiao Zeng, Duanhua Cai, Mingzhi Zhu, Ruimin Long, Dayun Yang, Ranjith Kumar Kankala, Shibin Wang, Yuangang Liu. Bioinspired red blood cell membrane-encapsulated biomimetic nanoconstructs for synergistic and efficacious chemo-photothermal therapy. Colloids and surfaces. B, Biointerfaces. 2020 May; 189(?):110842. doi: 10.1016/j.colsurfb.2020.110842. [PMID: 32058253]
  • Yuling Liu, Yingchong Chen, Longfei Lin, Hui Li. Gambogic Acid as a Candidate for Cancer Therapy: A Review. International journal of nanomedicine. 2020; 15(?):10385-10399. doi: 10.2147/ijn.s277645. [PMID: 33376327]
  • Chun-Yu Li, Qi Wang, Xiao-Min Wang, Guo-Xia Li, Shen Shen, Xiao-Lu Wei. Gambogic acid exhibits anti-metastatic activity on malignant melanoma mainly through inhibition of PI3K/Akt and ERK signaling pathways. European journal of pharmacology. 2019 Dec; 864(?):172719. doi: 10.1016/j.ejphar.2019.172719. [PMID: 31586634]
  • Yonghui Wang, Yana Sui, Yinggang Tao. Gambogic acid increases the sensitivity to paclitaxel in drug‑resistant triple‑negative breast cancer via the SHH signaling pathway. Molecular medicine reports. 2019 Nov; 20(5):4515-4522. doi: 10.3892/mmr.2019.10697. [PMID: 31545492]
  • Yilin Song, Yule Wang, Yan Zhu, Yu Cheng, Yidan Wang, Siyu Wang, Fengping Tan, Fan Lian, Nan Li. Biomodal Tumor-Targeted and Redox-Responsive Bi2 Se3 Hollow Nanocubes for MSOT/CT Imaging Guided Synergistic Low-Temperature Photothermal Radiotherapy. Advanced healthcare materials. 2019 08; 8(16):e1900250. doi: 10.1002/adhm.201900250. [PMID: 31290616]
  • Zhenlong Yu, Yanan Jv, Lu Cai, Xiangge Tian, Xiaokui Huo, Chao Wang, Baojing Zhang, ChengPeng Sun, Jing Ning, Lei Feng, Houli Zhang, Xiaochi Ma. Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90. Toxicology and applied pharmacology. 2019 05; 371(?):63-73. doi: 10.1016/j.taap.2019.03.028. [PMID: 30953615]
  • Li Wan, Qun Zhang, Sheng Wang, Yong Gao, Xiaofei Chen, Yang Zhao, Xiaoping Qian. Gambogic acid impairs tumor angiogenesis by targeting YAP/STAT3 signaling axis. Phytotherapy research : PTR. 2019 May; 33(5):1579-1591. doi: 10.1002/ptr.6350. [PMID: 31033039]
  • Dereje Kebebe, Yumei Wu, Bing Zhang, Jian Yang, Yuanyuan Liu, Xinyue Li, Zhe Ma, Peng Lu, Zhidong Liu, Jiawei Li. Dimeric c(RGD) peptide conjugated nanostructured lipid carriers for efficient delivery of Gambogic acid to breast cancer. International journal of nanomedicine. 2019; 14(?):6179-6195. doi: 10.2147/ijn.s202424. [PMID: 31447559]
  • Lili Liang, Zhixin Zhang, Xiaowei Qin, Ying Gao, Peng Zhao, Jing Liu, Weihui Zeng. Gambogic Acid Inhibits Melanoma through Regulation of miR-199a-3p/ZEB1 Signalling. Basic & clinical pharmacology & toxicology. 2018 Dec; 123(6):692-703. doi: 10.1111/bcpt.13090. [PMID: 29959879]
  • Rui Huang, Jiawei Li, Dereje Kebebe, Yumei Wu, Bing Zhang, Zhidong Liu. Cell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment. Drug delivery. 2018 Nov; 25(1):757-765. doi: 10.1080/10717544.2018.1446474. [PMID: 29528244]
  • Yan Zhang, Xinyi Tan, Tianyang Ren, Chao Jia, Zaixing Yang, Hong Sun. Folate-modified carboxymethyl-chitosan/polyethylenimine/bovine serum albumin based complexes for tumor site-specific drug delivery. Carbohydrate polymers. 2018 Oct; 198(?):76-85. doi: 10.1016/j.carbpol.2018.06.055. [PMID: 30093044]
  • Zhongcheng Ke, Lei Yang, Hao Wu, Zihao Li, Xiaobin Jia, Zhenghai Zhang. Evaluation of in vitro and in vivo antitumor effects of gambogic acid-loaded layer-by-layer self-assembled micelles. International journal of pharmaceutics. 2018 Jul; 545(1-2):306-317. doi: 10.1016/j.ijpharm.2018.04.016. [PMID: 29654896]
  • Wei-Lun Tang, Wei-Hsin Tang, Andras Szeitz, Jayesh Kulkarni, Pieter Cullis, Shyh-Dar Li. Systemic study of solvent-assisted active loading of gambogic acid into liposomes and its formulation optimization for improved delivery. Biomaterials. 2018 06; 166(?):13-26. doi: 10.1016/j.biomaterials.2018.03.004. [PMID: 29529479]
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